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Journal articles on the topic 'Physicochemical properties; Thin layer chromatography'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

A, Kolawole Jacob, and Bana DJ. "Comparative Evaluation of the Physicochemical and In Vitro Dissolution Properties of Some Expired and Unexpired Brands of Metformin Tablets." Der Pharma Chemica 15, no. 1 (2023): 9. https://doi.org/10.5281/zenodo.13318759.

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The comparative evaluation of the physicochemical properties and in vitro dissolution of some expired and unexpired brands of metformin tablets, six brands of expired (serial 1)and also unexpired (serial 2) of the same brand were used. The samples were determined using thin layer chromatography (TLC). Pharmacopoeia tests such as uniformity of weight, hardness, friability and assay were used to assess the physicochemical equivalence of the expired and unexpired metformin tablet brands. In vitro dissolution testing was conducted for both the expired and the unexpired tablets. All the brands (exp

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Jacob, A. Kolawole, and DJ Bana. "Comparative Evaluation of the Physicochemical and In Vitro Dissolution Properties of Some Expired and Unexpired Brands of Metformin Tablets." DER PHARMA CHEMICA 15, no. 1 (2023): 9. https://doi.org/10.4172/0975-413X.15.1.21-29.

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The comparative evaluation of the physicochemical properties and in vitro dissolution of some expired and unexpired brands of metformin tablets, six brands of expired (serial 1)and also unexpired (serial 2) of the same brand were used. The samples were determined using thin layer chromatography (TLC). Pharmacopoeia tests such as uniformity of weight, hardness, friability and assay were used to assess the physicochemical equivalence of the expired and unexpired metformin tablet brands. In vitro dissolution testing was conducted for both the expired and the unexpired tablets. All the brands (exp

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3

Kolawole, Jacob A., and DJ Bana. "Comparative Evaluation of the Physicochemical and In Vitro Dissolution Properties of Some Expired and Unexpired Brands of Metformin Tablets." Der Pharma Chemica 15, no. 1 (2023): 9. https://doi.org/10.5281/zenodo.10934596.

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The comparative evaluation of the physicochemical properties and in vitro dissolution of some expired and unexpired brands of metformin tablets, six brands of expired (serial 1)and also unexpired (serial 2) of the same brand were used. The samples were determined using thin layer chromatography (TLC). Pharmacopoeia tests such as uniformity of weight, hardness, friability and assay were used to assess the physicochemical equivalence of the expired and unexpired metformin tablet brands. In vitro dissolution testing was conducted for both the expired and the unexpired tablets. All the brands (exp

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Terekhov, A. A., A. V. Smirnov, A. N. Tokarev, I. V. Sokolov, and V. A. Ljunggren. "IDENTIFICATION OF ORGANOPHOSPHORUS COMPOUNDS BY THIN LAYER CHROMATOGRAPHY." International Journal of Veterinary Medicine, no. 4 (January 17, 2025): 263–68. https://doi.org/10.52419/issn2072-2419.2024.4.263.

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In conditions of intensive chemicalization of agriculture, cases of contamination of agricultural products with residual amounts of pesticides and veterinary drugs are increasing. A significant role among them is played by organophosphorus compounds, which, despite the relatively low danger to the body, are capable of accumulating in the fatty tissue of animals, which poses a threat to human health. Due to the wide variety of chemical groups of the substances used, differences in their physicochemical properties, method of application and environmental conditions, it is often difficult to accu

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G, Pratyusha, and Hiremath RS. "Chemical profiling of Mandak - A novel polyherbal combination." International Journal of Ayurvedic Medicine 15, no. 4 (2025): 1012–20. https://doi.org/10.47552/ijam.v15i4.5147.

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Introduction: In Ayurveda, drug formulation adheres to two principles: single-drug use and compound drug use, the latter known as polyherbalism. Mandak, a Novel Polyherbal combination of six drugs have shown better efficacy individually in the management of twak vikaras. Methods: This study aimed to evaluate raw and end product’s (Mandak) organoleptic, physicochemical, and phytochemical properties, along with chromatographic screenings via Thin Layer Chromatography (TLC) and High-Performance Thin Layer Chromatography (HPTLC), and Fourier Transform Infrared Spectroscopy (FTIR) to assess the syn

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Dan, Vu Ngoc, and V. F. Novikov. "Study of the sorption properties of solvents in thinlayer and column chromatography." Power engineering: research, equipment, technology 22, no. 2 (2020): 19–26. http://dx.doi.org/10.30724/1998-9903-2020-22-2-19-26.

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Much attention is paid to the consideration of the causes of transformer oil aging under the influence of technogenic and natural factors. The paper insulation destruction mechanism is considered, as a result of which furan compounds are formed that enter the transformer oil and worsen its dielectric characteristics. The characteristics of the domestic transformer oil grade GK-1 obtained using the technology of hydrocracking in a hydrogen medium are given. Furan compounds are formed in used transformer oil, which are monitored using chromatographic analysis methods according to standard proced

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Amrutha S. Babu, Mahadevan Subramaniam, Mahesh C. Kundagol, James Chacko, and Devipriya Soman. "Physico-chemical investigation of a polyherbal formulation - Vidangatandulaadi choorna." International Journal of Research in Pharmaceutical Sciences 11, SPL4 (2020): 1728–32. http://dx.doi.org/10.26452/ijrps.v11ispl4.4363.

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Vidangatandulaadi Choorna is a polyherbal formulation consisting of seven ingredients. Trivrith (Operculina turpethum (Linn.) Silva Manso) is the chief ingredient responsible for the purgative action of the formulation. This yoga is mentioned in Kalpasthana of Ashtangahridaya, intended for virechana (Purgation). It is useful in Kapha-vatha disorders. Even though many kinds of research have been done to identify the physicochemical constituents of individual drugs in the formulation, no studies were done to identify the physicochemical properties of the formulation. This analysis helps in under

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Paw, Beata, Rafał Śliwa, Łukasz Komsta, Bogusław Senczyna, Monika Karpińska, and Joanna Matysiak. "Comparison of HPLC, HPTLC, and In Silico Lipophilicity Parameters Determined for 5-Heterocyclic 2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazoles." Molecules 29, no. 11 (2024): 2478. http://dx.doi.org/10.3390/molecules29112478.

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The 5-heterocyclic 2-(2,4-dihydroxyphenyl)-1,3,4-thiadiazoles were obtained as potential biologically active compounds. Lipophilicity is one of the most important physicochemical properties of compounds and was already taken into account during the drug candidates design and development. The lipophilicity of compounds was determined using the computational (log P) and chromatography (log kw, RMw) methods. The experimental ones included the reverse-phase column high performance liquid chromatography RP (HPLC) with C8, C18, phosphatidylcholine (IAM), and cholesterol stationary phases and the thi

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Achenbach, Juliane, Nicola Deyerling, Mariana Mello dos Santos, Sharmin Sultana, Md Khairul Islam, and Cornelia Locher. "Physicochemical Properties, Antioxidant Activity, and High-Performance Thin-Layer Chromatography Profiling of Propolis Samples from Western Australia." Plants 13, no. 14 (2024): 1919. http://dx.doi.org/10.3390/plants13141919.

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This study reports on the physicochemical and antioxidant properties of propolis samples from various regions across Western Australia and identifies some phenolic constituents using high-performance thin-layer chromatography (HPTLC). Total phenolic content (TPC) was determined using a modified Folin–Ciocalteu assay, and antioxidant activity was investigated with the Ferric Reducing Antioxidant Power (FRAP) assay and also visualised and semi-quantified by HPTLC-DPPH analysis. TPC values ranged from 9.26 to 59.3 mg gallic acid equivalent/g of raw propolis and FRAP assay data from 4.34 to 53.8 m

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Ghotbi, Golaleh, Maryam Hamzeh-Mivehroud, Arezou Taghvimi, Soodabeh Davaran, and Siavoush Dastmalchi. "Investigation of Experimental and In Silico Physicochemical Properties of Thiazole-Pyridinium Anti-Acetylcholinesterase Derivatives with Potential Anti-Alzheimer’s Activity." Pharmaceutical Sciences 27, no. 3 (2020): 366–77. http://dx.doi.org/10.34172/ps.2020.81.

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Background: Physicochemical properties play important role in fundamental issues like absorption and distribution of pharmaceuticals to the target tissue. This is particularly importantfor drugs acting in central nervous system (CNS). In this study, physicochemical properties of previously synthesized thiazole-pyridinium derivatives with anti-acetylcholinesterase activity and possible anti-Alzheimer effect were studied. Methods: Partition coefficient (n-octanol/water) and chromatographic Rf values for the studied compounds were determined using shake flask and high performance thin layer chrom

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11

Abdelwahab, Siddig Ibrahim, Manal Mohamed Elhassan Taha, Hassan Ahmed Alhazmi, et al. "Phytochemical profiling of Costus (Saussurea lappa Clarke) root essential oil, and its antimicrobial and toxicological effects." Tropical Journal of Pharmaceutical Research 18, no. 10 (2021): 2155–60. http://dx.doi.org/10.4314/tjpr.v18i10.22.

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Purpose: To carry out gas chromatography-mass spectrometry (GC-MS) analysis of the phytochemical content of the root essential oil of Saussurea lappa Clarke Asteraceae (Costus, SLEO), and to evaluate its physicochemical, antimicrobial and cytoxic properties. Methods: The oil was extracted from the plant’s roots by steam distillation using a Clevenger system. Various physicochemical parameters for the oil including refractive index, color, acid value, saponification number, ester and peroxide values were measured. Flavonoid content was assessed using thin layer chromatography (TLC). Therm

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Taneja, Neeraj, Aftab Alam, Ranjana Patnaik, Tannu Taneja, Awaneet Kaur, and Shivang Dhoundiyal. "Exploring Plumbago Zeylanica Linn’s Anticancer Potential: In Vitro Phytochemical Analysis." Journal of Indian Academy of Oral Medicine and Radiology 36, no. 2 (2024): 126–31. https://doi.org/10.4103/jiaomr.jiaomr_13_24.

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Abstract Background: Plumbago zeylanicum, commonly known as `Chitramula’ and `Chitrak’ and belonging to the family Plumbaginaceae, is a rambling perennial under shrub grown in most parts of India. The present work deals with the pharmacognostical and preliminary phytochemical studies on the roots of Plumbago zeylanica Linn. Objectives: This study aimed to look at the preliminary phytochemical screening and pharmacognostic characteristics of P. zeylanicum roots. Material and Methods: Macroscopy, microscopy, phytochemical screening, physicochemical parameters, and the production of thin-layer ch

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Kulkarni, Aloknath A., Prachi P. Gujar, Ashok A. Hajare, and Chandrakant S. Magdum. "Development and Optimization of Advanced Microwave assisted extraction for Cucurbita pepo oil: A Phytochemical and Physico-chemical screening perspectiv." Journal of Ayurvedic and Herbal Medicine 3, no. 2 (2017): 78–82. http://dx.doi.org/10.31254/jahm.2017.3205.

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The objective of this study is to optimize the operational conditions of the microwave-assisted extraction (MWE) of seeds of Cucurbita pepo (C. pepo) and phytochemical, physicochemical screening of extract (fixed oil) which is responsible for the medicinal properties of the plant. Optimal conditions for microwave extractions proposed were 700 Watt microwave power, 70 ml solvent volume and 10 min extraction time. Total 14.57% extract was yielded using microwave assisted extraction method compared to 8.1% by traditional Soxhlet extraction method. The solvent selection was based on the extraction

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Yadav, Vijay Kumar, Raghuveer Irchhiaya, and A. K. Ghosh. "PHYTOCHEMICAL AND PHARMACOGNOSTICAL STUDIES OF ANOGEISSUS ACUMINATA." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 450–57. http://dx.doi.org/10.22270/jddt.v9i4-a.3507.

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Medicinal plants are one of the oldest valuable sources of medicine provide by nature to mankind. Medicinal plants are one of the important sources of research of new drugs. Many medicinal plants and herbs hold their prestigious position in the field of natural medicine among which Anogeissus acuminata belonging to family Combretaceae was vital one. In the present study was intended to evaluate various physicochemical, phytochemical standards like TLC, HPTLC and Pharmacognostic parameters which will be helpful to ensure the purity, safety and efficacy of the medicinal plant. Anogei

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Ciura, Krzesimir, Joanna Fedorowicz, Filip Andrić, et al. "Lipophilicity Determination of Quaternary (Fluoro)Quinolones by Chromatographic and Theoretical Approaches." International Journal of Molecular Sciences 20, no. 21 (2019): 5288. http://dx.doi.org/10.3390/ijms20215288.

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Lipophilicity is a vital physicochemical parameter of a molecule, which affects several biological processes such as absorption, tissue distribution, and pharmacokinetic properties. In this study, evaluation of lipophilicities of a series of novel fluoroquinolone-Safirinium dye hybrids using chromatographic and computational methods is presented. Fluoroquinolone-Safirinium dye hybrids have been synthesized as new dual-acting hydrophilic antibacterial agents. Reversed phase thin-layer chromatography and micellar electrokinetic chromatography experiments were carried out. Furthermore, logP value

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16

Gu, Jiabao, Ziyan Jiao, Tao Wang, Bolin Zhang, and Hongfei Zhao. "Glucans with Different Degrees of Polymerization from Leuconostoc mesenteroides CICC6055: Analysis of Physicochemical Properties and Intestinal Prebiotic Function." International Journal of Molecular Sciences 25, no. 1 (2023): 258. http://dx.doi.org/10.3390/ijms25010258.

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This study explored the physicochemical properties and prebiotic activities of glucans and oligoglucans. Oligoglucans were obtained through the fermentation of Leuconostoc mesenteroides CICC6055 and the glucansucrase of strain CICC6055, while glucans were obtained only through fermentation. Thin-layer chromatography and high-performance liquid chromatography identified enzymatically synthesized oligoglucans with a higher yield. Differential scanning calorimetry and derivative thermogravimetry analyses revealed the heat resistance of the glucans and oligoglucans at 280–300 °C. Fourier transform

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Honey, Raval*1 Shreya Jetpariya1 Shreya Patel1 Nandan Ladani1 Radhika Soni2 Dr. Tejal Gandhi3. "Herbal Antifungal Gel Formulation: A Tea Tree Oil-Based Approach for Topical Fungal Infections." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 3532–37. https://doi.org/10.5281/zenodo.15115602.

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Fungal infections, including dermatophytoses and candidiasis, have become more prevalent due to environmental changes and weakened immune systems. Herbal treatments are gaining attention as safe and effective alternatives to conventional therapies. This study focuses on creating a herbal antifungal gel containing tea tree oil, renowned for its antifungal, antimicrobial, and anti-inflammatory properties. The gel formulation also includes stabilizers and preservatives such as Carbopol, propylene glycol, triethanolamine, and di-sodium EDTA to enhance stability, spreadability, and preservation. Th

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Noman, Abeer Essam, Naif S. Al-Barha, and Fusheng Chen. "Characterization of Physicochemical Properties of Melanin Produced by Gluconobacter oxydans FBFS 97." Fermentation 8, no. 11 (2022): 574. http://dx.doi.org/10.3390/fermentation8110574.

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The present study aimed to characterize melanin pigment extracted from Gluconobacter oxydans FBFS 97. After 14 days of culture at 28 °C in GY (glucose and yeast extract) liquid-state medium, G. oxydans FBFS97 produce the maximum melanin, up to about 12–15 mg/L. The physicochemical characteristics of the extracted melanin showed an ability to dissolve in 1 mol/L NaOH or 1 mol/L KOH, and insolubility in water and most organic solvents, such as chloroform and petroleum ether. The extracted melanin was confirmed to be exact melanin by ultraviolet-visible spectrophotometry, Fourier-transform infrar

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Mello dos Santos, Mariana, Tomislav Sostaric, Lee Yong Lim, and Cornelia Locher. "Physicochemical Characteristics, Antioxidant Properties, and Identification of Bioactive Compounds in Australian Stingless Bee Honey Using High-Performance Thin-Layer Chromatography." Molecules 30, no. 6 (2025): 1223. https://doi.org/10.3390/molecules30061223.

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This study investigates the physiochemical properties, chemical composition, and antioxidant activity of Australian stingless bee honey blends from two bee species, Tetragonula carbonaria and Tetragonula hockingsi, harvested in Burpengary East, Queensland at different times of the year. The moisture content of the honey samples ranged from 26.5% to 30.0%, total soluble solids from 70.0 to 73.5° Brix, and pH from 3.57 to 4.19. The main sugars identified were trehalulose (13.9 to 30.3 g/100 g), fructose (12.9 to 32.3 g/100 g), and glucose (4.80 to 23.7 g/100 g). The total phenolic content (TPC),

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Ibekwe, Nneka N., Ayooluwakitan M. Mamora, Maryann Okoye, Tiwalade A. Adelakun, and Obi P. Adigwe. "Physicochemical properties of teas sold in Abuja, Nigeria, and evaluation of their caffeine content using HPLC." Journal of Pharmacy & Bioresources 19, no. 1 (2022): 33–42. http://dx.doi.org/10.4314/jpb.v19i1.5.

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Tea is commonly consumed in Nigeria. Caffeine, a major constituent in tea, has some beneficial pharmacological properties, but can negatively affect human health if consumed excessively. The objective of the study was to evaluate some physicochemical properties and caffeine content of teas marketed in FCT, Abuja, Nigeria. Ten commercial brands of teas (8 black teas and 2 green teas) were assessed for weight variation, moisture content and pH tests using standard methods. Extraction of caffeine was carried out and the identity determined by thin layer chromatography and melting points, respecti

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Sriyani, Maula Eka, Maudy Shintia, Endah Rosyidiah, Witri Nuraeni, Adinda Saraswati, and Eva Maria Widyasari. "Physicochemical Properties Of 131I-Rutin Under Acidic Labeling Condition As A Radiolabeled Compound For The Diagnosis Of Cancer." Jurnal Sains dan Teknologi Nuklir Indonesia 22, no. 1 (2021): 24. http://dx.doi.org/10.17146/jstni.2021.22.1.6286.

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Radiolabeled rutin (131I-rutin) has potential use in future diagnosis of cancer. The physicochemical characteristics of 131I-rutin are essential in regard to its distribution and accumulation in the body. Therefore, to ensure successful delivery of a labeled compound, it is necessary to evaluate its physicochemical properties. The labeling of 131I-rutin was accomplished using the oxidation method assisted by Chloramine-T under acidic conditions. Radiochemical purity value was measured by thin-layer chromatography (TLC-SG F254) using 100% methanol as the mobile phase. The electrical charge of 1

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Pal, Pinki, Shiv Bhadra Singh, and Aaditya Singh. "DETERMINATION OF PHYSICOCHEMICAL PROPERTIES, ANTIOXIDANT CONSTITUENTS BY HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY FINGERPRINTING, AND ANTIOXIDANT ACTIVITY OF CUCURBITA MAXIMA SEEDS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 280. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.23552.

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Objective: The present study is designed to evaluate preliminary phytochemical constituents, physiochemical properties evaluation, free radical scavenging activity, and high-performance thin-layer chromatography (HPTLC) fingerprinting analysis of Cucurbita maxima seed oil.Methods: Total phenol content, total flavonoid content, total tannin content, 1, 1-diphenyl, 2-picryl-hydrazyl (DPPH) radical scavenging method, and HPTLC fingerprinting analysis for compounds responsible for antioxidant activity were used.Result: Phytochemical screening shows the presence of constituents such as alkaloids, g

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Anu, A., U. Chitra, and N. Anbu. "STANDARDISATION OF MURUNGAI NEI: A SIDDHA FORMULATION." International Journal of Research in Ayurveda and Pharmacy 14, no. 4 (2023): 58–62. http://dx.doi.org/10.7897/2277-4343.1404113.

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Murungai Nei (Moringa ghee) is a multi-herbal formulation indicated as an aphrodisiac and spermatogenic in Siddha literature. The study aims to standardise the Murungai Nei’s quality, purity, and safety through its physicochemical, microbiological, chromatographic, and biochemical parameters. Physicochemical parameters like loss on drying, total ash, acid-insoluble ash, water-soluble ash, water-soluble extractive, alcohol-soluble extractive, and pH were found to be 0.03%, 0.0499%, 0.0199%, 0.07%, 0.1934%, and 18.49% respectively, which denote the purity and quality of the drug in this study. Q

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Sneha CJ, Sneha CJ, Greeshma KM Greeshma KM, Bijeshmon PP Bijeshmon PP, Meera Mohan K. Meera Mohan K, and Vincent EJ Vincent EJ. "Pharmacognostic Evaluation and HPTLC Profiling of Callisia Fragrans (Lindl.) Woodson – A Traditionally Used Medicinal Plant." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1994–2000. https://doi.org/10.35629/4494-100219942000.

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Callisia fragrans (Lindl.) Woodson, a perennial plant of the family Commelinaceae, has long been valued in traditional medicine for its anti-inflammatory, antimicrobial, and woundhealing properties. Despite its ethno medicinal significance, scientific validation and standardization data remain limited. The present study aimed to evaluate the pharmacognostic characteristics of Callisia fragrans through physicochemical analysis, preliminary phytochemical screening, and High Performance Thin Layer Chromatography (HPTLC) fingerprinting. Physicochemical parameters, including, total ash, acid-insolu

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Serges, Gbamelé Kouakou Kan, Yayé Yapi Guillaume, Bonouman Ira Ama Valerie, Anigbé Amon Maurice, Chatigre Kouamé Olivier, and Djaman Allico Joseph. "Antifungal and antioxidant activities of Carapa procera oil and its physicochemical characteristics." GSC Biological and Pharmaceutical Sciences 10, no. 2 (2020): 130–37. https://doi.org/10.5281/zenodo.4280549.

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<em>Carapa procera</em> oil is traditionally used for various pathologies including dermatoses. This study evaluates two the method of extraction of oil. The physicochemical characteristics, the antioxidant activity, and the antifungal properties were conducted respectively according to the ISO methods, DPPH method, and disc method plates while a phytochemical screening was performed by the colouring method, and the Thin Layer Chromatography (TLC). The results revealed that the iodine, saponification and refraction index vary from 68.50 to 73.11 gI2/100 g, 197.70 to 198 mgKOH/g and 1.46 r

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ISA, Hassanatu, Katsayal Umar Adam mni Adam, Abdurahman Ezzeldin Mukhtar Abdurahman, Maje Idris Mohammed Mohammed, and Abdulhamid Zakir Abdulhamid. "Pharmacognostic studies and thin layer chromatography profile of the aerial parts of Vernonia cinerealess. (Asteraceae)." Journal of Current Biomedical Research 3, no. 6, November-December (2023): 1336–63. http://dx.doi.org/10.54117/jcbr.v3i6.3.

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Vernonia cinerea(VC) Less is synonymously known as Cyanthillium cinereum and Vernonia abbreviate belongs to Asteraceae family. Different parts of the plant are extensively used in traditional medicine for treatment of various disease conditions. However, there was no scientific evaluation of the plant’s pharmacognosy and thin layer chromatography (TLC), which necessitate these studies, to bring out characters that will facilitate its proper identification, standardization and, nature of secondary metabolites in aerial parts of the plant. To carry out detailed pharmacognostic studies and TLC ev

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Debajyoti, Chakraborty, Sharma Mahima, Mehere Nikhil, et al. "A comparative analysis of physicochemical and antioxidant profiles of wild and cultivated Shatavari (Asparagus racemosus Willd) roots." Journal of Drug Research in Ayurvedic Sciences 9, Suppl 2 (2024): S213—S223. https://doi.org/10.4103/jdras.jdras_254_24.

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Abstract BACKGROUND: Shatavari (Asparagus racemosus Willd), known for its Rasayana, properties, holds significant medical, research, and economic values, especially due to its potent aphrodisiac attributes. However, the rising demand for A. racemosus has triggered unsustainable harvesting practices, habitat destruction, and deforestation, pushing the species toward endangerment in the wild. Due to its extensive utilization for medicinal and nutritional purposes, the cultivation of Shatavari has become increasingly essential to meet growing demand while alleviating pressure on wild populations.

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Mishra, Rakhi. "Physicochemical, Phytochemical and Antioxidant Study of Pyrus Malus." General Medicine and Clinical Practice 8, no. 5 (2025): 01–09. https://doi.org/10.31579/2639-4162/256.

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Background/Aim: Pyrus malus (apple), commonly utilized in traditional medicine, is gaining interest for its therapeutic potential. However, standardized information on its mother tincture and raw drug material is limited. This study aimed to establish a comprehensive profile of Pyrus malus through physicochemical, phytochemical, and chromatographic analyses to support its pharmaceutical standardization. Materials and Methods: The mother tincture and raw drug material of Pyrus malus leaves were analyzed using standard pharmacopoeial procedures. Physicochemical parameters such as pH, alcohol con

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Chervyakova, L., T. Panchenko, and O. Tsurkan. "Features of analytical control of glyphosate salts in preparative formulations." Interdepartmental Thematic Scientific Collection of Phytosanitary safety, no. 69 (March 14, 2024): 283–91. https://doi.org/10.36495/phss.2023.69.283-291.

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Goal. Development of a method of analytical control of glyphosate in preparative forms of herbicides. Methods. Determination of glyphosate was carried out by the chromatographic method of thin-layer chromatography (TLC) using Sorbfil plates with a thin layer of silica gel KSK adsorbent. The active substance was identified by the value of Rf, quantitative determination was based on the formalized dependence of the size of the area of the chromatographic zones on the amount of glyphosate. Results. Physicochemical properties of herbicides — electrolytes, to which glyphosate belongs, create specia

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Chervyakova, L., T. Panchenko, and O. Tsurkan. "Features of analytical control of glyphosate salts in preparative formulations." Interdepartmental Thematic Scientific Collection of Phytosanitary safety, no. 69 (March 14, 2024): 283–91. http://dx.doi.org/10.36495/1606-9773.2023.69.283-291.

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Goal. Development of a method of analytical control of glyphosate in preparative forms of herbicides. Methods. Determination of glyphosate was carried out by the chromatographic method of thin-layer chromatography (TLC) using Sorbfil plates with a thin layer of silica gel KSK adsorbent. The active substance was identified by the value of Rf, quantitative determination was based on the formalized dependence of the size of the area of the chromatographic zones on the amount of glyphosate. Results. Physicochemical properties of herbicides — electrolytes, to which glyphosate belongs, c

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Sowa, Ireneusz, Ryszard Kocjan, Magdalena Wójciak-Kosior, Ryszard Świeboda, Dominika Zajdel, and Mieczysław Hajnos. "Physicochemical properties of silica gel coated with a thin layer of polyaniline (PANI) and its application in non-suppressed ion chromatography." Talanta 115 (October 2013): 451–56. http://dx.doi.org/10.1016/j.talanta.2013.05.071.

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Menezes Filho, Antonio Carlos Pereira de, Luciene Teixeira Gonçalves Romão, Eloisa Borges dos Reis, et al. "Chromatographic analysis and physicochemical evaluation of the essential oil of Bauhinia monandra Kurz flowers." Research, Society and Development 9, no. 8 (2020): e454985979. http://dx.doi.org/10.33448/rsd-v9i8.5979.

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The study of chromatographic techniques, classical and modern, describes the simplicity and, at the same time, the advances that this area has undergone in recent years in quality scientific research and also in learning in undergraduate and postgraduate courses around the world. This paper investigate a characterization by thin layer chromatography (TLC) and gas chromatography coupled with mass spectrometry (GC-MS), as a method developed by graduate students that involve a combination of a classic and modern technique, as well as results about the physicochemical properties of the essential o

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Dewi, Rizna Triana, Gian Primahana, Abdi Wira Septama, et al. "Quality control standardization of Indonesian noni fruit (Morinda citrifolia) extract and evaluation of their angiotensin-converting enzyme inhibitory activity." Pharmacia 69, no. 3 (2022): 709–17. http://dx.doi.org/10.3897/pharmacia.69.e86854.

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Morinda citrifolia fruit (Noni) has been used as a folk medicine in several countries. Noni possessed various pharmacological activities such as; anticancer, antidiabetic, antihypertensive, antarthritic, and antioxidants. The present study evaluated pharmacognostic properties, profiling of active constituent through High-Performance Thin Layer Chromatography (HPTLC) and Liquid Chromatography-High Resolution Mass Spectrometer (LC-HRMS) run for quantitative and qualitative phytochemical analysis and determining angiotensin-converting enzyme (ACE) inhibitor activity of Noni from three different l

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Dewi, Rizna Triana, Gian Primahana, Abdi Wira Septama, et al. "Quality control standardization of Indonesian noni fruit (Morinda citrifolia) extract and evaluation of their angiotensin-converting enzyme inhibitory activity." Pharmacia 69, no. (3) (2022): 709–17. https://doi.org/10.3897/pharmacia.69.e86854.

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Morinda citrifolia fruit (Noni) has been used as a folk medicine in several countries. Noni possessed various pharmacological activities such as; anticancer, antidiabetic, antihypertensive, antarthritic, and antioxidants. The present study evaluated pharmacognostic properties, profiling of active constituent through High-Performance Thin Layer Chromatography (HPTLC) and Liquid Chromatography-High Resolution Mass Spectrometer (LC-HRMS) run for quantitative and qualitative phytochemical analysis and determining angiotensin-converting enzyme (ACE) inhibitor activity of Noni from three different l

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Sethuramani A, Chandrasamy M, Ajith P, and Saranya S. "A Holistic Approach to the Pharmacognostic and Proximate Analysis of Cleome rutidosperma DC Leaves: Insights for Taxonomic Refinement." IJPAR JOURNAL 13, no. 4 (2024): 888–901. https://doi.org/10.61096/ijpar.v13.iss4.2024.888-901.

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The Hydro alcoholic extract of Cleome rutidosperma (HAECR) leaf was analyzed by gas chromatography-mass spectrometry (GC-MS). The anatomical, physicochemical, and pharmacognostic properties of the extract were analyzed. The results showed that the leaves of HAECR exhibit organoleptic and macroscopical characteristics, showing distinctive features that enhance its taxonomic profile. The powder microscopy of the leaf reveals key microscopic features, including epidermal cell density, stomatal density, palisade ratio, and vein structure. The fluorescence analysis of the powder under visible, shor

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Karolina, Wanat, Rojek Agata, and Brzezińska Elżbieta. "Computational Approach to Drug Penetration across the Blood-Brain and Blood-Milk Barrier Using Chromatographic Descriptors." Cells 12, no. 3 (2023): 421. http://dx.doi.org/10.3390/cells12030421.

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Drug penetration through biological barriers is an important aspect of pharmacokinetics. Although the structure of the blood-brain and blood-milk barriers is different, a connection can be found in the literature between drugs entering the central nervous system (CNS) and breast milk. This study was created to reveal such a relationship with the use of statistical modelling. The basic physicochemical properties of 37 active pharmaceutical compounds (APIs) and their chromatographic retention data (TLC and HPLC) were incorporated into calculations as molecular descriptors (MDs). Chromatography w

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Namrata, M. Waghmare*1 Manisha G. Pate2 Jayshree S. Dalal3 Prasad P. Jumde4. "The pharmacognostic study, phytochemical screening, and TLC of Allamanda Cathartica L. Plant." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 726–37. https://doi.org/10.5281/zenodo.10981349.

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<strong>Objective:</strong> This study aimed to investigate the phytochemical properties of Allamanda cathartica L. (Golden Trumpet) and explore its potential therapeutic applications. <strong>Methods:</strong> Various parts of the plant, including leaves, stems, and flowers, were collected and subjected to phytochemical screening and thin-layer chromatography. The extracts were analyzed for alkaloids, tannins, flavonoids, phytosterols, saponins, fixed oils, and carbohydrates. Total flavonoid content was estimated using the aluminum-chloride spectroscopic assay. Microscopical analysis and phys

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Gayaki, Pranjali, Shailju Gurunani, Khushi Popali, Bhrunali Gharpure, Irshaad Ahmed, and Dinesh Chaple. "Comparative Evaluation of In-House Prepared and Marketed Chaturbeeja Churna." International Journal of Ayurvedic Medicine 16, S2 (2025): 200–206. https://doi.org/10.47552/ijam.v16is2.6241.

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The standardization and quality control of herbs and herbal dosage forms with proper integration of modern scientific technique and traditional knowledge is important. The term 'standardization' refers to all actions undertaken during manufacturing and quality control to ensure consistent and reproducible product quality. The present study focuses on the comprehensive comparative evaluation of in-house prepared and marketed Chaturbeeja Churna. Chaturbeeja Churna is a classical ayurvedic formulation traditionally used for managing metabolic disorders. The formulation, comprises of four seeds vi

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Kadela-Tomanek, Monika, Maria Jastrzębska, Krzysztof Marciniec, Elwira Chrobak, Ewa Bębenek, and Stanisław Boryczka. "Lipophilicity, Pharmacokinetic Properties, and Molecular Docking Study on SARS-CoV-2 Target for Betulin Triazole Derivatives with Attached 1,4-Quinone." Pharmaceutics 13, no. 6 (2021): 781. http://dx.doi.org/10.3390/pharmaceutics13060781.

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A key parameter in the design of new active compounds is lipophilicity, which influences the solubility and permeability through membranes. Lipophilicity affects the pharmacodynamic and toxicological profiles of compounds. These parameters can be determined experimentally or by using different calculation methods. The aim of the research was to determine the lipophilicity of betulin triazole derivatives with attached 1,4-quinone using thin layer chromatography in a reverse phase system and a computer program to calculate its theoretical model. The physiochemical and pharmacokinetic properties

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de Araújo, Patricia Rocha, Bruno Fonseca-Santos, Ana Carolina Kogawa, Hérida Regina Nunes Salgado, and Marlus Chorilli. "A Review of Analytical Methods for the Determination of Hypericin in Foods, Herbal, Biological and Pharmaceutical Matrices." Current Pharmaceutical Design 26, no. 36 (2020): 4648–57. http://dx.doi.org/10.2174/1381612826666200531145624.

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Aims: A review of analytical methods for the determination of hypericin in foods, herbal, biological and pharmaceutical matrices. Background: Hypericin (HYP) is a naturally-occurring pigment obtained from some plants of the genus Hypericum. Although HYP has been known for many years, it has recently attracted attention due to its varied biological properties, such as anti-inflammatory and antidepressant activity and it is also an efficient photosensitizer. Objective: The objective of this review is to provide insights into the physicochemical properties of HYP, as well as to report the analyti

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Koutsaviti, Aikaterini, Marina Milenković, and Olga Tzakou. "Antimicrobial Activity of the Essential Oil of Greek Endemic Stachys spruneri and its Main Component, Isoabienol." Natural Product Communications 6, no. 2 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600231.

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The essential oils of Stachys spruneri Boiss. (sample A and sample B) were analyzed by GC and GC-MS. (+)-Isoabienol was the dominant component (49.5 and 48.2%, respectively of the total oils) among seventy-two identified constituents. Isoabienol was separated, purified by preparative thin-layer chromatography, and further identified by means of physicochemical and spectrometric analysis. The microbial growth inhibitory properties of the essential oil and its main metabolite, the labdane diterpene isoabienol, were determined using the broth microdilution method against eight laboratory strains

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Talybov, G. М. "Synthesis of propargyl(allyl) aryloxyethers." Voprosy Khimii i Khimicheskoi Tekhnologii, no. 5 (November 2024): 42–47. http://dx.doi.org/10.32434/0321-4095-2024-156-5-42-47.

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A convenient method for the synthesis of propargyl(allyl) aryloxyethers is proposed. It is notable that the synthesized compounds exhibit increased reactivity and are rich in nucleophilic centers. Experimental data have established that these compounds are stable and do not undergo hydrolysis. The yields of the target products in both cases are up to 89.2%. The reaction duration and the volume of substituents at the alkoxy group do not significantly affect the yield of the target products. The composition of the synthesized compounds includes groups of signals from protons of the allyl and pro

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Trabelsi, Imen, Sirine Ben Slima, Naourez Ktari, Mohamed Bouaziz, and Riadh Ben Salah. "Structure Analysis and Antioxidant Activity of a Novel Polysaccharide from Katan Seeds." BioMed Research International 2021 (January 12, 2021): 1–13. http://dx.doi.org/10.1155/2021/6349019.

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In the present work, a novel water-soluble polysaccharide (LWSP) was purified from Katan seeds. Polysaccharide was structurally characterized by NMR spectroscopic analysis, thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), Fourier-transform infrared spectroscopy (FTIR) analysis, X-ray diffraction (XRD), and UV absorption. TLC and HPLC showed that LWSP was a polysaccharide consisted mainly of glucose, mannose, xylose, and arabinose. The FTIR spectrum and UV absorption proved polysaccharide characteristic of LWSP. According to XRD, LWSP presented a semicrystalline b

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Hartanti, Dwi, Worawan Kitphati, Penchom Peungvicha, and Nutputsorn Chatsumpun. "Pharmacognostic specifications and the antioxidant activity of Curcuma comosa Roxb. crude drugs." PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) 19, no. 1 (2023): 159. http://dx.doi.org/10.30595/pharmacy.v19i1.13782.

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Curcuma comosa Roxb. is popularly used to treat gynecological problems but has no official monograph in the Thai Herbal Pharmacopeia (THP). This study characterized the selected pharmacognostic and physicochemical specifications and antioxidant potentials of C. comosa crude drugs. The pharmacognostic and physicochemical properties of two kinds of crude drugs were characterized according to the WHO quality control methods for herbal materials. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity, ferric reducing antioxidant power (FRAP), and total phenolic content (TPC) were evaluated a

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Starek, Małgorzata, Alina Plenis, Marta Zagrobelna, and Monika Dąbrowska. "Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases." Pharmaceutics 13, no. 4 (2021): 440. http://dx.doi.org/10.3390/pharmaceutics13040440.

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Lipophilicity study of selected NSAIDs, the group of the bioactive compounds usually used in humans and animals medicine, with the use of experimental and calculation methods was evaluated. LogP values are proposed and compared as descriptors of the lipophilicity of eleven compounds (from oxicams and coxibs). Obtained data were designated by thin-layer chromatography (TLC) in various chromatographic conditions, with stationary phases with different properties. The mobile phase systems were prepared by mixing the respective amounts of water and organic modifier, methanol and acetone, in the ran

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Morak-Młodawska, Beata, Małgorzata Jeleń, Emilia Martula, and Rafał Korlacki. "Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action." International Journal of Molecular Sciences 24, no. 8 (2023): 6970. http://dx.doi.org/10.3390/ijms24086970.

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Lipophilicity is one of the key properties of a potential drug that determines the solubility, the ability to penetrate through cell barriers, and transport to the molecular target. It affects pharmacokinetic processes such as adsorption, distribution, metabolism, excretion (ADME). The 10-substituted 1,9-diazaphenothiazines show promising if not impressive in vitro anticancer potential, which is associated with the activation of the mitochondrial apoptosis pathway connected with to induction BAX, forming a channel in MOMP and releasing cytochrome c for the activation of caspases 9 and 3. In th

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Nycz–Empel, Anna, Katarzyna Bober, Mirosław Wyszomirski, Ewa Kisiel, and Andrzej Zięba. "The Application of CA and PCA to the Evaluation of Lipophilicity and Physicochemical Properties of Tetracyclic Diazaphenothiazine Derivatives." Journal of Analytical Methods in Chemistry 2019 (October 20, 2019): 1–10. http://dx.doi.org/10.1155/2019/8131235.

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The subject of the study was 11 new synthetized tetracyclic diazaphenothiazine derivatives. Using thin-layer chromatography in a reverse phase system (RP-TLC), their RM0 lipophilicity parameter was determined. The mobile phase was composed of 0.2 M Tris buffer (pH = 7.4) and acetone (POCH S.A., Gliwice, Poland) in different concentrations. Using computer programs, based on different computational algorithms, theoretical values of lipophilicity (AClogP, ALOGP, ALOGPs, miLogP, MLOGP, XLOGP2, and XLOGP3) as well as molecular descriptors (molecular weight, volume of a molecule, dipole moment, pola

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Rzepka, Zuzanna, Katarzyna Bober-Majnusz, Justyna Magdalena Hermanowicz, et al. "Assessment of the Lipophilicity of Indole Derivatives of Betulin and Their Toxicity in a Zebrafish Model." Molecules 29, no. 18 (2024): 4408. http://dx.doi.org/10.3390/molecules29184408.

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There are scientific studies indicating that the attachment of an indole moiety to the triterpene scaffold can lead to increased anticancer potential. Lipophilicity is one of the factors that may influence biological properties and is therefore an important parameter to determine for newly obtained compounds as drug candidates. In the present study, previously synthesized 3 and/or 28-indole-betulin derivatives were evaluated for lipophilicity by reversed-phase thin-layer chromatography. The experimental values of lipophilicity (logPTLC) were then subjected to correlation analysis with theoreti

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Novak, Jasna, Katarina Butorac, Andreja Leboš Pavunc, et al. "A Lactic Acid Bacteria Consortium Impacted the Content of Casein-Derived Biopeptides in Dried Fresh Cheese." Molecules 27, no. 1 (2021): 160. http://dx.doi.org/10.3390/molecules27010160.

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This study aimed to define a consortium of lactic acid bacteria (LAB) that will bring added value to dried fresh cheese through specific probiotic properties and the synthesis of bioactive peptides (biopeptides). The designed LAB consortium consisted of three Lactobacillus strains: S-layer carrying Levilactobacillus brevis D6, exopolysaccharides producing Limosilactobacillus fermentum D12 and plantaricin expressing Lactiplantibacillus plantarum D13, and one Enterococcus strain, Enterococcus faecium ZGZA7-10. Chosen autochthonous LAB strains exhibited efficient adherence to the Caco-2 cell line

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Issa, Tahani Osman, Ahmed Ibrahim Mohamed Ahmed, Yahya Sulieman Mohamed, Sakina Yagi, Abdelrafie Mohamed Makhawi, and Tarig Osman Khider. "Physiochemical, Insecticidal, and Antidiabetic Activities of Senna occidentalis Linn Root." Biochemistry Research International 2020 (September 15, 2020): 1–9. http://dx.doi.org/10.1155/2020/8810744.

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The present study aimed to investigate the physiochemical activities of Senna occidentalis (Linn) roots and phytochemicals as insecticidal (ethyl acetate and methanol) and antidiabetic (ethanolic extract) activities. Physicochemical properties were carried out by using Association of Official Analytical Chemist methods; thin layer chromatography was carried out according to the Stahl method. Larvicidal activity and LD50 were studied against the third instar of Culex quinquefasciatus mosquito larvae to detect and extract toxicity. The ethanolic extracts of the roots were orally tested at the do

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