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Relevant bibliographies by topics / Physiological Chemistry / Dissertations / Theses

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Dissertations / Theses on the topic 'Physiological Chemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Keatch, Steven Alexander. "Biophysical chemistry of EcoKI in physiological solutions : emulating the cell interior." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/12335.

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Production of polyamines and nucleoid-associated proteins is tightly regulated and restructures the nucleoid-associated proteins is tightly regulated and restructure the nucleoid under environmental conditions that induce DNA damage into an even more highly condensed conformation. These ‘stressful’ conditions can cause the specific methylation sequence of DNA to be lost, which leaves the DNA open to self-attack by restriction enzymes. One such enzyme is EcoKI, a type I restriction enzyme that protects the bacterial cell by destroying foreign invading DNA. Upon loss of specific methylation, Eco

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2

Sturrock, Anna M. "Environmental and physiological influences on otolith chemistry in a marine fish." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/359373/.

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The aim of this project was to determine whether otolith trace dement chemistry can be used [Q track migrations in fully marine fish. This question was addressed through a semi-controlled experiment where Irish Sea and North Sea plaice (Pleurononectes platessa) were maintained in a monitored environment. The relationships between water, blood and otolith chemistry were assessed and with reference to environmental and physiological variables and through comparisons of otolith trace clement chemistry in wild plaice tagged by data storage tags (DST).

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3

Chen, Yuan-Han. "The active site chemistry of factor inhibiting HIF-1, coordination, bonding, and reaction." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/dissertations/AAI3372258/.

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4

Camp, Emma F. "Ecological and physiological responses of hard corals to variations in seawater carbonate chemistry." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/15340/.

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It is predicted that ocean acidification (OA) threatens coral reefs worldwide, by lowering seawater pH which in turn compromises essential metabolic processes such as carbonate genesis of corals. Inshore waters however, experience different spatial and temporal carbonate chemistry variability, raising questions over the future impact of OA within these habitats. It also remains unclear whether local biogeochemical conditions of some marine habitats can buffer, or provide a refuge against OA. The thesis systematically examines the response (ecological abundance, distribution, recruitment, and m

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5

Want, Andrew James. "Physiological studies on bacterial fermentations using multi-parameter flow cytometry." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1048/.

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Two staining protocols were formulated that enabled the detection of cellular stress at the single-cell level for Bacillus cereus. Both DiOC6(3) and RedoxSensor Green™ can be employed to detect perturbations in the energetic status of the cell at concentrations of 0.30 \mug.mL-1 and 3.0 \muM respectively. These methods can be employed for sensitive analysis of bacteria of both industrial and clinical interest. Flow cytometry was used throughout this work in order to assess the quality of recombinant Escherichia coli populations present within an agitated bioreactor. It was demonstrated in shak

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6

Wilson, Andrew N. A. "The pharmacological and physiological properties of adenosine on the heart." Thesis, Cardiff University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278717.

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7

Pang, Fung-Yin. "Tribulin : an analysis of its components, distribution and physiological significance." Thesis, University of Westminster, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283455.

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8

Maianti, Juan Pablo. "Therapeutic potential and physiological roles of Insulin-Degrading Enzyme illuminated by a DNA-templated macrocyclic inhibitor." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467523.

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Insulin-Degrading Enzyme (IDE) is a zinc-metalloprotease responsible for the clearance of insulin in peripheral tissues. Despite decades of speculation that inhibiting endogenous insulin degradation might treat Type-2 Diabetes, the functional relationship between IDE and glucose homeostasis remains unclear. IDE inhibitors that are active in vivo are therefore needed to elucidate IDE’s physiological roles and to determine its potential to serve as a target for the treatment of diabetes. In this thesis I describe the development of the first highly specific IDE in vivo probe, identified from

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9

Mundoma, Claudius. "Sulfur chemistry st[r]ucture and reactivity of substituted thioreas and aminothiols of physiological importance /." Morgantown, W. Va. : [West Virginia University Libraries], 1999. http://etd.wvu.edu/templates/showETD.cfm?recnum=1067.

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10

Gabrielli, William Fullard. "Structure activity relationship studies of ochratoxin A analogues." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53070.

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Thesis (MSc)--Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: Mycotoxins have assumed worldwide importance due to the ubiquitous occurrence of toxigenic fungi, their infestation of plant-based foods and feeds and the subsequent economical and health impact it because of their contamination of commercial products. Ochratoxin A (OA) is a nephrotoxic mycotoxin produced by isolates of Aspergillus ochraceus and Penicillium verrucosum and occurs frequently in nature. The major target for toxicity of OA in mammalian species is the kidneys and it has been the major cause of Danish Porcine N

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11

Akay, Senol. "Diagnosis and Inhibition Tools in Medicinal Chemistry." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/41.

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Cell surface saccharides are involved in a variety of essential biological events. Fluorescent sensors for saccharides can be used for detection, diagnosis, analysis and monitoring of pathological processes. The boronic acid functional group is known to bind strongly and reversibly to compounds with diol groups, which are commonly found on saccharides. Sensors that have been developed for the purpose of saccharide recognition have shown great potential. However, they are very hydrophobic and this lack of essential water-solubility makes them useful in biological applications. The first section

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12

Cheng, Alan 1972. "The physiological and cellular functions of PTPIB in obesity and cancer /." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82844.

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Protein tyrosine phosphatase 1B (PTP1B) is the prototype for the superfamily of protein tyrosine phosphatases, and has been implicated in multiple signaling pathways. Of particular interest, gene targeting studies in mice have established PTP1B as a critical physiological regulator of insulin signaling and PTP1B knockout mice are resistant to both diabetes and obesity. At the start of this thesis, the mechanism underlying the role of PTP1B in obesity was not completely understood. Furthermore, the importance of PTP1B in cellular and oncogenic signaling was not well established. My docto

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13

Lea, Michelle Louise. "A physiological study of Streptomyces capreolus and factors governing growth and capreomycin biosynthesis." Thesis, Liverpool John Moores University, 2007. http://researchonline.ljmu.ac.uk/5869/.

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14

Povozhaev, Lea May. "Flesh, Blood, and Word: Creativity and Writing as Physiological Phenomena." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1116435792.

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15

Di, Falco Marcos Rafael. "Development of growth factor-cytokine fusion proteins with increased hematopoietic activity : physiological and cellular effects." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82853.

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Hematopoietic precursor cells express cell surface receptors for a variety of cytokines and growth factors. These hematopoietic secreted humoral factors can influence the proliferation, differentiation, survival and mobilisation of blood stem cells. Moreover, simultaneous exposure to different combinations of hematopoietic hormones can synergistically affect one or more of these cellular responses. Our laboratory has been involved in studying the role played by insulin-like growth factors (IGFs) in hematopoiesis. IGFs are known to stimulate the expansion of precursor cells from various

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16

Stobart, Michael David. "The chemistry of a new water-recirculation aquaculture system with emphasis on the influence of ozone on water quality." Thesis, Rhodes University, 1992. http://hdl.handle.net/10962/d1005087.

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Water quality changes that occur during establishment and maintenance of nitrification in two identical recirculating aquaculture systems containing rainbow trout are described. The time taken for the nitrification process to become established was 40-45 days. Mortality of fish attributed to elevated nitrite concentrations were recorded during the initial conditioning phase of the systems. Un-ionised ammonia concentrations did not attain lethal levels during this period. Nitrate concentrations accumulated slowly throughout the study, while the pH and alkalinity of the water decreased with prog

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17

Bell, Benjamin. "Advancing the application of analytical techniques in the biological chemistry of sporopollenin : towards novel plant physiological tracers in Quaternary palynology." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/advancing-the-application-of-analytical-techniques-in-the-biological-chemistry-of-sporopollenin-towards-novel-plant-physiological-tracers-in-quaternary-palynology(59605f2b-642a-4ea9-8921-4c926217e6f2).html.

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Palynology, the study of organic microfossils, is an important tool for improving our understanding of past environments and landscapes. Palynology provides a wealth of information from which climatic and environmental conditions can be inferred. However, inferred climatic and environmental conditions are often open to interpretation. Assumptions made about past climate conditions from pollen assemblages often rely on qualitative understanding of modern-day vegetation distributions, rather than empirical relationships. Historic anthropogenic impact on the environment must also be inferred, and

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18

Francis, Kevin. "On the Biochemistry, Mechanism and Physiological Role of Fungal Nitronate Monooxygenase." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/chemistry_diss/51.

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Nitronate monooxygenase (E.C. 1.13.11.16), formerly known as 2-nitropropane dioxygenase (EC 1.13.11.32), is a flavin dependent enzyme that catalyzes the oxidation of nitronates to their corresponding carbonyl compounds and nitrite. Despite the fact that the enzyme was first isolated from Neurospora crassa 60 years ago, the biochemical and physiological properties of nitronate monooxygenase have remained largely elusive. This dissertation will present the work that established both the catalytic mechanism and physiological role of the fungal enzyme. The biological and biochemical properties of

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19

Schmelz, Eric Alexander. "The role of phytoecdysteroids in spinach (Spinacia oleracea): Physiological responses to below ground herbivory support a plant defense hypothesis." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/288960.

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Polyhydroxylated steroids with insect molting hormone activity were discovered in plants over thirty years ago. The major endogenous molting hormone of insects is believed to be 20-hydroxyecdysone (20E) and interestingly, it is also the most commonly encountered phytoecdysteroid (PE) in plants. Ecdysteroids control developmental programs in both immature and adult insects however, the role of PEs in plants has not been demonstrated. PEs are hypothesized to function as either plant hormones or plant defenses against phytophagous insects. Many toxic secondary metabolites are concentrated in apic

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20

Lambat, Zaynab Yusuf. "Cimetidine as a free radical scavenger." Thesis, Rhodes University, 2003. http://hdl.handle.net/10962/d1003244.

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The present study was undertaken to determine the effects and possible mechanism of action of cimetidine in cancer and Alzheimer’s disease (AD). Throughout this study emphasis is placed on free radical levels since the magnitude of the relationship between diseases and the levels of free radicals vary from one disease to another. Studies were carried out to examine the effect of cimetidine on free radical levels using superoxide formation and lipid peroxidation as indicators of free radical levels. The experiments revealed that addition of cimetidine, especially in high concentrations (0.5 and

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21

Bucknall, Martin Paul Medical Sciences Faculty of Medicine UNSW. "Dityrosine as a biomarker of free radical induced oxidative damage in diseases of ageing." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/30207.

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o,o???-Dityrosine (dityrosine), an oxidation product of tyrosine produced by reaction between tyrosyl radicals, is becoming established as a biomarker of free radical oxidative protein damage in vivo. Attempts to measure dityrosine concentrations in various physiological and pathological systems have produced varied and often contradictory results. Dityrosine concentrations in urine, plasma, cerebrospinal fluid (CSF) and brain tissue varying over three orders of magnitude have been reported, together with inconsistent claims of significant dityrosine elevation in several ageing-related patho

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22

Wu, Wan Man. "Reactive oxygen species and murine malaria." Thesis, The University of Sydney, 1992. https://hdl.handle.net/2123/26446.

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The aim of this study was to investigate the role of ROS in the protective and pathological immune response during malarial infection. For this purpose, four isolates of Plasmodium parasites (P. berghei ANKA, P. vinckei, P. berghei K152 and P. chabaudi) and two different inbred strains of mice (CBA and DBA) were used. The patterns of mortality varied between the different mouseparasite strain combinatio ns. The mortality of CBA mice infected with P. vinckei and P. berghei K152, and DBA mice infected with P. berghei ANKA, related to the levels of parasitaemia. However early mortality of CBA

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23

Tokunaga, Tomohisa. "Synthesis and application of ω-ethynyl fatty acids to analyze the physiological functions of eicosapentaenoic acid". Kyoto University, 2018. http://hdl.handle.net/2433/232362.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21161号<br>農博第2287号<br>新制||農||1060(附属図書館)<br>学位論文||H30||N5135(農学部図書室)<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授栗原達夫, 教授小川順, 教授阪井康能<br>学位規則第4条第1項該当

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24

Mizdrak, Jasminka. "Human lens chemistry: UV filters and age-related nuclear cataract." Australia : Macquarie University, 2007. http://hdl.handle.net/1959.14/16855.

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"A thesis submitted in partial fulfillment of the requirements for the award of the degree of Doctor of Philosophy".<br>Thesis (PhD) -- Macquarie University, Division of Environmental and Life Sciences, Dept. of Chemistry and Biomolecular Sciences, 2007.<br>Bibliography: p. 243-277.<br>Introduction -- A convenient synthesis of 30HKG -- Facile synthesis of the UV filter compounds 30HKyn and AHBG -- Synthesis, identification and quantification of novel human lens metabolites -- Modification of bovine lens protein with UV filters and related metabolites -- Effect of UV light on UV filter-treated

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25

Lemaire, Jérémy. "Mercury contamination in caimans from French Guiana, bioaccumulation and physiological effects." Thesis, La Rochelle, 2021. https://tel.archives-ouvertes.fr/tel-03716076.

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Le mercure (Hg) est un contaminant environnemental qui affecte tous les écosystèmes. Il a la particularité de se biomagnifier le long de la chaîne trophique et de se bioaccumuler dans les tissus des prédateurs. Le Hg est connu pour avoir des effets néfastes chez les humains et la faune sauvage. Les prédateurs des écosystèmes tropicaux sont particulièrement affectés par la contamination en Hg du fait de l’exploitation aurifère artisanale qui utilise d’importantes quantités de Hg pour extraire l’or. Les crocodiliens sont des super-prédateurs des écosystèmes tropicaux et ils accumulent de fortes

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26

Boyd, Clinton Shane. "An investigation into dopamine-melatonin interactions in the rat Corpus striatum and pineal gland: a possible pineal-striatal axis." Thesis, Rhodes University, 2000. http://hdl.handle.net/10962/d1003965.

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Dysfunction of central dopaminergic systems has been implicated in neuroendocrine, neurodegenerative and psychiatric disorders. Monoamine oxidase and catechol-Omethyltransferase represent the key catabolic enzymes of dopamine, terminating neurotransmission following synaptic release of this catecholamine. Thus, both enzymes have been associated with the pathology of dopaminergic systems and represent therapeutic targets elf enormous clinical importance. Some neuroendocrine and circadian effects of melatonin have been attributed to an antidopamimetic effect of this pineal hormone in the hypotha

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27

Castada, Hardy Zingalaoa. "Brewster Angle Microscopy Study of Model Lung Surfactant Systems at the Air-Water and Air-Physiological Buffer Interfaces." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1281642097.

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28

Wohaieb, Saleh A. "Oxygen free radical scavenging systems in clinical and experimental (chemical and spontaneous) diabetes mellitus." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/27567.

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The extent to which endogenous free radical-scavenging defense mechanisms are involved in experimental and human diabetes was investigated in various tissues of animals with chemically-induced or spontaneous diabetes (BB Wistar rats) and in erythrocytes of patients with either Type I or Type II diabetes. Diabetes was induced in female Wistar rats using alloxan (ALX) or streptozotocin (STZ), each administered in a dose of 50 mg/kg body wt., intravenously. The present study also included a group -of animals in which body wt. loss was induced by food-deprivation for 72 h. The effects of pharmaco

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29

Franco, Rohini-Ann. "Effect of Estrogen on LPS-induced human endothelial cell adhesion moledule expression and calcium signaling." Scholarly Commons, 2005. https://scholarlycommons.pacific.edu/uop_etds/627.

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30

Wijeweera, Priyantha. "Phytochemical basis for the anxiolytic activity of the ayurvedic medicinal plant Centella asiatica (L) Urb (gotukola)." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26349.

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Gotukola (Centella asiatica L. Urban) (Apiaceae), its extracts and the pure compound asiaticoside were studied for anxiolytic activity in thirteen standardized rat trials. High performance liquid chromatography (HPLC) was used to conduct the phytochemical analysis. Among different models tested, the most promising positive response for anxiolytic activity was observed in the elevated plus maze test conducted with: (a) whole plant materials, (b) ethyl acetate and methanol fractions and (c) asiaticoside. The results show for the first time that asiaticoside and triterpene enriched fractions of g

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31

Palvie, Stefanie Michelle. "An investigation into the neuroprotective effects of dehydroepiandrosterone." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003260.

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Dehydroepiandrosterone, a C-19 steroid, is found endogenously with the highest circulating serum levels. It is converted to important steroids such as the sex hormones oestrogen and testosterone. DHEA has come under the spotlight as a purported “fountain of youth” due to its well-characterised age-related decline. The supplementation of DHEA in both the elderly and those with a pathophysiological deficiency has been shown to be of benefit, particularly with regard to wellbeing and depression. The role of DHEA in the periphery has not been elucidated beyond its role as a precursor hormone in se

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32

Schumacher, Soeren. "Saccharide recognition : boronic acids as receptors in polymeric networks." Phd thesis, Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5286/.

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In this thesis entitled “Saccharide Recognition - Boronic acids as Receptors in Polymeric Networks” different aspects of boronic acid synthesis, their analysis and incorporation or attachment to different polymeric networks and characterisation thereof were investigated. The following key aspects were considered: • Provision of a variety of different characterised arylboronic acids and benzoboroxoles • Attachment of certain derivatives to nanoparticles and the characterisation of saccharide binding by means of isothermal titration calorimetry and displacement assay (ARS) to enhance the ass

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33

Wang, Jialu. "Facile Methods for the Analysis of Lysophosphatidic Acids in Human Plasma." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2235.

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Lysophosphatidic acid (LPA) influences many physiological processes, such as brain and vascular development. It is associated with several diseases including ovarian cancer, breast cancer, prostate cancer, colorectal cancer, hepatocellular carcinoma, multiple myeloma atherosclerotic diseases, cardiovascular diseases, pulmonary inflammatory diseases and renal diseases. LPA plasma and serum levels have been reported to be important values in diagnosing ovarian cancer and other diseases. However, the extraction and quantification of LPA in plasma are very challenging because of the low physiologi

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34

Chu, Yu-Hsuan. "Custom Fluorophores for Investigating the Cellular Uptake Mechanisms and Side-Effects of Pharmaceuticals." PDXScholar, 2015. http://pdxscholar.library.pdx.edu/open_access_etds/2343.

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There is a significant current need to elucidate the molecular mechanisms of the side-effects caused by widely-used pharmaceuticals. Examples include the acute nephrotoxicity and irreversible ototoxicity promoted by the cationic drugs gentamicin and cisplatin. Gentamicin is an aminoglycoside antibiotic used for the prevention and treatment of life-threatening gram-negative bacterial infections, such as tuberculosis and meningitis. Cisplatin is used to treat a broad spectrum of cancers including head and neck, ovarian, cervical, stomach, bladder, sarcoma, lymphoma, testicular cancer and others.

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35

Liu, Chia-chi. "Oxidation of ascorbate by protein radicals in simple systems and in cells." Phd thesis, Australia : Macquarie University, 2007. http://hdl.handle.net/1959.14/16746.

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Thesis (PhD) -- Macquarie University, Division of Environmental and Life Sciences, Dept. of Chemistry and Biomolecular Sciences, 2007.<br>Bibliography: leaves 295-322.<br>Generation of peroxide groups in proteins exposed to a wide variety of reactive oxygen species (ROS) requires an initial formation of protein carbon-centred or peroxyl free radicals, which can be reduced to hydroperoxides. Both protein radicals and protein hydroperoxides are capable of oxidizing important biomolecules and thus initiate biological damage. In this study, we investigated the inhibition of protein hydroperoxide f

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36

Hoffman, Marjorie A. "Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically relevant conditions." Thesis, University of Missouri - Columbia, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10180877.

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<p> Hydrogen sulfide (H<sub>2</sub>S) is more commonly known for its toxic properties; however, recently, there has been evidence that this small, gaseous molecule could serve as an endogenous cell-signaling agent. Surprisingly, a number of studies have also provided evidence that H<sub> 2</sub>S is a DNA-damaging mutagen. Using a plasmid-based DNA strand cleavage assay, we examined the chemical mechanisms of DNA damage by H<sub>2</sub>S. We found single-strand DNA cleavage was caused by micromolar concentrations of H<sub>2</sub>S. The mechanistic process was studied and was shown to involve t

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37

Turner, Kendrick Bruce. "CELL AND PROTEIN-BASED SENSING SYSTEMS FOR THE DETECTION OF ENVIRONMENTALLY AND PHYSIOLOGICALLY RELEVANT MOLECULES." UKnowledge, 2011. http://uknowledge.uky.edu/chemistry_etds/1.

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The detection of small molecules in complex sample matrices such as environmental (surface and ground water, sediment, etc.) and biological (blood, serum, plasma, etc.) samples is of paramount importance for monitoring the distribution of environmental pollutants and their patterns of exposure within the population as well as diagnosing and managing diseases. Biosensors have demonstrated a singular ability to sensitively and selectively detect analytes in complex samples without the need for extensive sample preparation and pretreatment. Nature has demonstrated myriad examples of exquisite sel

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"Physiological chemistry of zinc in malaria and diabetes." NORTHWESTERN UNIVERSITY, 2010. http://pqdtopen.proquest.com/#viewpdf?dispub=3386519.

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Kalish, John M. "Fish otolith chemistry as an indicator of physiological, ecological and environmental events." Thesis, 1989. https://eprints.utas.edu.au/20164/7/Whole_KalishJohnM1991_thesis%20exc%20pub%20mat.pdf.

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Fish otoliths are calcium carbonate aggregates in the membranous labyrinth of all teleost fishes. The deposition of these structures is affected by both physiological and environmental factors which can cause changes in both the rate of otolith depositon and in the composition of the material deposited. The rate of otolith deposition, particularly in regard to the alternation of calcium carbonate-rich and protein-rich zones, has been widely investigated in an attempt to understand processes of ageing and growth in fishes. Aspects of the chemistry of these structures, particularly trace

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40

Mohamedali, Khalid Amanali. "The role of mouse adenosine deaminase in purine metabolism: Physiological and mechanistic aspects." Thesis, 1994. http://hdl.handle.net/1911/16758.

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Recent studies on the tissue distribution and developmental regulation of ADA activity in mice show that very high ADA levels exist in the murine alimentary tract (tongue, esophagus, forestomach, proximal small intestine) and at the fetal-maternal interface. Levels of three other enzymes involved in purine catabolism--purine nucleoside phosphorylase (PNP), guanine deaminase (GDA), and xanthine dehydrogenase (XDH)--were measured and compared with ADA activity. The highest levels of PNP, GDA and XDH were found in the proximal small intestine. Levels of these three enzymes were much lower in the

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41

"Physiological regulation of growth and tylosin biosynthesis in Streptomyces fradiae." Tulane University, 1994.

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In this study, several aspects of the physiological regulation of tylosin biosynthesis in Streptomyces fradiae, strain C373.1 are examined. As with most secondary metabolite fermentations, tylosin biosynthesis involves a sequence of many metabolic reactions with complex (and several unknown) regulatory elements. So far, structural gene cloning approaches were of limited success. The general philosophy of the approach in this dissertation is based on the expectation that exploring and identifying specific regulatory elements could lead to more rational strategies for improvement of fermentation

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Mazloumi, Nastaran. "The physiological responses of King George whiting to a changing environment." Thesis, 2015. http://hdl.handle.net/2440/100781.

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Environmental variability affects the physiology of marine ectotherms, causing changes to metabolic rate, locomotion and growth. Species that move between habitats with different temperature and salinity for spawning purposes may experience significant changes in their growth rate and physiology compared to those that live in stable environments. Ectotherms have a temperature and salinity range at which growth and survival are optimal. Although, ectotherms are capable of tolerating a range of temperatures and salinities, moving from optimal to extreme ranges can affect oxygen consumption, loco

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43

Wang, Bo. "Analysis of physiological roles of Drosophila calmodulin through in vivo genetic and in vitro structure/function studies." Thesis, 2003. http://hdl.handle.net/1911/18578.

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Calmodulin (CaM), a small protein found in all eukaryotes examined, is a major component of Ca2+ signaling pathways and functions as a Ca2+ signal sensor and transducer. A wide variety of targets are regulated by CaM, including enzymes, cytoskeleton elements and ion channels. To dissect the in vivo roles of Drosophila CaM, a series of Cam mutations were previously generated in the Beckingham lab. This thesis primarily concerns investigation of two Cam mutations; Cam7, a point mutation encoding V91G mutant CaM, and a null mutation, Camn339. Cam7 causes unprecedented defects. Cam 7 mutants are

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"Specialization of a calmodulin-like protein: Androcam adopts a single conformation over the entire physiological range of calcium." Thesis, 2010. http://hdl.handle.net/1911/61964.

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The ubiquitous and highly conserved calcium binding protein calmodulin exhibits structural plasticity, broad target binding specificity and the ability to tune its affinity for Ca2+ ion. Collectively, these properties enable calmodulin to transduce biological calcium signals to hundreds of downstream targets. Despite the versatility of calmodulin, metazoans express many essential calmodulin-like proteins that perform tissue specific functions. In this thesis, I have studied androcam, an essential protein in D.melanogaster that is 67% identical to calmodulin, to determine how its structure, Ca+

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Husemann, Michael Helmut. "Levels of key enzymes and physiological factors involved in product formation in batch and continuous cultures of Clostridium acetobutylicum ATCC 824." Thesis, 1989. http://hdl.handle.net/1911/16243.

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A number of physiological factors and their relation to the solventogenesis mechanism were investigated in both batch and continuous cultures of Clostridium acetobutylicum. The initiation of butanol formation in batch culture correlates best with minimum levels of undissociated butyric acid in the medium. Weak organic acids have uncoupling characteristics and effect a concentration-dependent decrease in the transmembrane $\Delta$pH and the intracellular pH (pH$\sb{i}$). The pH$\sb{i}$ decreases continuously from 7.0 to 5.5 in batch cultures and cell growth terminates when the pH$\sb{i}$ drops

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Babity, Samuel. "The design of polymeric microneedles for the delivery of sensors for real-time physiological monitoring." Thèse, 2019. http://hdl.handle.net/1866/23565.

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Ce mémoire de maîtrise porte sur le développement d’un système d’administration de microaiguilles pour livrer des sondes et des capteurs fluorescents dans le contexte du diagnostic et de la surveillance des soins de santé. Bien que parfois négligés en faveur des soins de santé axés sur le traitement, le diagnostic précoce de la maladie et la surveillance préventive des paramètres biologiques peuvent considérablement améliorer les résultats des soins de santé et joueront probablement un rôle plus important dans les années à venir. Cependant, il reste des obstacles importants à cette approche, à

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Nelson, Matthew Jay. "Impact of N-2-mercaptopropionylglycine (MPG) and simvastatin on exercise-induced cardiac adaptations." 2008. http://hdl.handle.net/2152/17945.

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Experiments were conducted to investigate the role of free radicals in exercise induced cardiac adaptations and to determine if statin administration would adversely affect cardiac adaptations to exercise. In the first experiment myocardial antioxidant enzymes, cardiac function and cardiac hypertrophy were assessed following a chronic exercise protocol previously used by our lab. MPG effectively reduced myocardial oxidative stress and activation of the signaling proteins Akt and S6 following an exercise bout. Skeletal muscle mitochondria content increased to similar levels in E and E+MPG. Simi

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Du, Zheyuan. "Chemical Stability of Curcumin: Structure and Activity Relationship (SAR) Study." 2016. https://scholarworks.umass.edu/masters_theses_2/347.

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Over the past decades, numerous studies have shown that curcumin has potent biological activities. As a potential chemopreventing agent, curcumin was demonstrated to exert anti-cancer effects in both in vitro and in vivo studies. However, low bioavailability of curcumin limited human clinical trials and its application to be formulated as therapeutics. In this thesis, we will summarize the anti-cancer effects of curcumin in animal studies and clinical trials. In addition, an SAR study will be introduced to elucidate the mechanism of curcumin degradation at physiological pH. We synthesized vari

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"Effect of oxidized and hyperoxidized guanine on DNA primer-template structures." 2009. http://library.cuhk.edu.hk/record=b5896585.

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Fenn, Dickson.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references (leaves 74-81).<br>Abstract also in Chinese.<br>Title Page --- p.i<br>Thesis Committee --- p.ii<br>Acknowledgement --- p.iii<br>Table of Contents --- p.v<br>List of Tables --- p.ix<br>List of Figures --- p.x<br>List of Abbreviations and Symbols --- p.xv<br>Abstract --- p.xvii<br>Chapter 1.Chapter One: --- Introduction --- p.1<br>Chapter 1.1 --- Oxidation and Hyperoxidation of Guanine --- p.1<br>Chapter 1.2. --- DNA Replication --- p.2<br>Chapter 1.3 --- Mutagenesis ---

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"Antioxidative and vascular effects of kudingcha (Ligustrum purpurascens)." 2000. http://library.cuhk.edu.hk/record=b5890462.

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Wong Yuen Fan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2000.<br>Includes bibliographical references (leaves 134-150).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGMENTS --- p.i<br>ABSTRACT --- p.ii<br>LIST OF ABBREAIATIONS --- p.vii<br>TABLE OF CONTENTS --- p.ix<br>Chapter Chapter 1 --- General introduction<br>Chapter 1.1 --- History of Kudingcha --- p.1<br>Chapter 1.2 --- Classification of Kudingcha --- p.1<br>Chapter 1.3 --- Composition of Kudingcha --- p.3<br>Chapter 1.4 --- Introduction to phenylethanoid glycosides --- p.4<br>Chapter 1.4.1 --- Isolation and purif

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