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Journal articles on the topic 'Physiological system of the connective tissue'

Author: Grafiati

Published: 28 May 2022

Last updated: 31 July 2025

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1

Grove, Christina, Oliver Peschel, and Andreas G. Nerlich. "A Systematic Approach to the Application of Soft Tissue Histopathology in Paleopathology." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/631465.

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The application of histology to soft tissue remains offers an important technique to obtain diagnostically important information on various physiological and pathological conditions in paleopathology. In a series of 29 cases with mummified tissue ranging between 16 months and c. 5.200 years of postmortem time interval, we systematically investigated paleohistology and the preservation of various tissues. We established a reproducible histological ranking system for the evaluation of mummified tissue preservation. The application of this scheme to the series showed good tissue preservation of t

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2

Marchuk, Carolina, and Carla Stecco. "The role of connective tissue in the embryology of the musculoskeletal system: towards a paradigm shift." F1000Research 4 (August 27, 2015): 635. http://dx.doi.org/10.12688/f1000research.6824.1.

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This paper presents a review of literature regarding the role of embryological connective tissue in the formation of muscles and the organization of the musculoskeletal system. The intention is to introduce a potential paradigm shift with regards to understanding peripheral coordination of movement and movement patterns. This new perspective could improve comprehension of the normal physiological function of connective tissue and, whenever it is pathological, resultant symptoms. Furthermore, this paper briefly discusses some implications of this paradigm shift in the interpretation of movement

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Kodama, Yuya, Shin Masuda, Toshinori Ohmori, et al. "Response to Mechanical Properties and Physiological Challenges of Fascia: Diagnosis and Rehabilitative Therapeutic Intervention for Myofascial System Disorders." Bioengineering 10, no. 4 (2023): 474. http://dx.doi.org/10.3390/bioengineering10040474.

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Damage to the fascia can cause significant performance deficits in high-performance sports and recreational exercise and may contribute to the development of musculoskeletal disorders and persistent potential pain. The fascia is widely distributed from head to toe, encompassing muscles, bones, blood vessels, nerves, and internal organs and comprising various layers of different depths, indicating the complexity of its pathogenesis. It is a connective tissue composed of irregularly arranged collagen fibers, distinctly different from the regularly arranged collagen fibers found in tendons, ligam

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Karamova, L. M., Natalya V. Vlasova, and A. V. Basharova. "THE EMPLOYMENT EXPERIENCE DETERMINATION OF HEALTH DISORDERS IN WORKERS OF PHTHALATE PRODUCTION." Health Care of the Russian Federation 62, no. 3 (2019): 152–56. http://dx.doi.org/10.18821/0044-197x-2018-62-3-152-156.

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The article presents the results of complex hygienic and physiological studies of conditions of labor of workers of chemical industry. The age and seniority determinacy of health disorders. The alterations of cardio-vascular, nervous systems, ENT-organs, musculoskeletal system and connective tissue are established. In workers of main group unidirectional alterations are established concerning indices of peripheral blood characterized by anemic syndrome, neutrophil leukocytosis, lymphocytosis, eosinophilia and expressed thrombocytopenia.

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Covantev, Serghei. "An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System." Iberoamerican Journal of Medicine 3, no. 1 (2020): 56–64. http://dx.doi.org/10.53986/ibjm.2021.0010.

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Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this article is presented a review of studies on mast cells regarding their physiological role in cental nervous system. We also disscuss their role in several conditions like: multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuropsychiatric disorders, cerebrovascular disorders a

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Zügel, Martina, Constantinos N. Maganaris, Jan Wilke, et al. "Fascial tissue research in sports medicine: from molecules to tissue adaptation, injury and diagnostics: consensus statement." British Journal of Sports Medicine 52, no. 23 (2018): 1497. http://dx.doi.org/10.1136/bjsports-2018-099308.

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The fascial system builds a three-dimensional continuum of soft, collagen-containing, loose and dense fibrous connective tissue that permeates the body and enables all body systems to operate in an integrated manner. Injuries to the fascial system cause a significant loss of performance in recreational exercise as well as high-performance sports, and could have a potential role in the development and perpetuation of musculoskeletal disorders, including lower back pain. Fascial tissues deserve more detailed attention in the field of sports medicine. A better understanding of their adaptation dy

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Sodikova, Z. Sh, S. J. Xojanazarova, and S. A. Koriev. "MORPHOLOGICAL FEATURES OF THE BRONCHUS OF THE LUNG IN CHILDREN FROM 8 TO 12 YEARS OF AGE." International Journal of Medical Sciences And Clinical Research 4, no. 6 (2024): 18–23. http://dx.doi.org/10.37547/ijmscr/volume04issue06-04.

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The pulmonary vessels and their endothelium plays the role of a physiological barrier for numerous biologically active substances, then the epithelium and connective tissue basis of the airways perform a barrier-protective function in relation to various environmental factors [1]. The bronchial secret produced by the mucous membrane is the result of the complex integration of the transudation of the plasma components of the blood, the secretory activity of the bronchial epithelium, glands, the cells of the connective tissue and blood cells (neutrophils, fat cells, eosinophils, macrophages, etc

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Serghei, Covantev. "An Overview of the Physiological and Pathological Role of Mast Cells in the Central Nervous System." Iberoamerican Journal of Medicine 3, no. 1 (2020): 56–64. https://doi.org/10.5281/zenodo.4271553.

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Neurological disorders present a major group of diseases with the global prevalence of 6.3%. They are responsible for 12% global mortality. Mast cells are one of the most abundantly present cell of the immune system in the connective tissue and the central nervous system is not an exception. In this article is presented a review of studies on mast cells regarding their physiological role in cental nervous system. We also disscuss their role in several conditions like: multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer’s disease, neuropsychiatric disorders, cerebrovascular disor

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9

Kubota, Satoshi, and Masaharu Takigawa. "Cellular and molecular actions of CCN2/CTGF and its role under physiological and pathological conditions." Clinical Science 128, no. 3 (2014): 181–96. http://dx.doi.org/10.1042/cs20140264.

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CCN family protein 2 (CCN2), also widely known as connective tissue growth factor (CTGF), is one of the founding members of the CCN family of matricellular proteins. Extensive investigation on CCN2 over decades has revealed the novel molecular action and functional properties of this unique signalling modulator. By its interaction with multiple molecular counterparts, CCN2 yields highly diverse and context-dependent biological outcomes in a variety of microenvironments. Nowadays, CCN2 is recognized to conduct the harmonized development of relevant tissues, such as cartilage and bone, in the sk

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10

Norrby, Klas. "On Connective Tissue Mast Cells as Protectors of Life, Reproduction, and Progeny." International Journal of Molecular Sciences 25, no. 8 (2024): 4499. http://dx.doi.org/10.3390/ijms25084499.

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The connective tissue mast cell (MC), a sentinel tissue-residing secretory immune cell, has been preserved in all vertebrate classes since approximately 500 million years. No physiological role of the MC has yet been established. Considering the power of natural selection of cells during evolution, it is likely that the MCs exert essential yet unidentified life-promoting actions. All vertebrates feature a circulatory system, and the MCs interact readily with the vasculature. It is notable that embryonic MC progenitors are generated from endothelial cells. The MC hosts many surface receptors, e

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Wątroba, Sławomir, Tomasz Wiśniowski, Jarosław Bryda, and Jacek Kurzepa. "Characteristics of matrix metalloproteinases and their role in embryogenesis of the mammalian respiratory system." Postępy Higieny i Medycyny Doświadczalnej 75 (January 25, 2021): 24–34. http://dx.doi.org/10.5604/01.3001.0014.6933.

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The human respiratory system appears as an outgrowth from the ventral wall of the primary foregut and its development includes a series of subsequent processes, dependent on the interactions between endothelial cells, respiratory epithelium and extracellular matrix (ECM). These interactions determine the acquisition of normal structural and functional features of the newly created tissues. The essential role in the morphogenesis of the respiratory system is performed by matrix metalloproteinases (MMPs). MMPs are endopeptidases containing zinc ion in their active center, necessary for the proce

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Kolesnikova, L. R., O. A. Makarova, L. V. Natyaganova, M. I. Dolgikh, and L. I. Korytov. "Metabolism and Physiological Functions Adjustment of the Organism under Stress Influence." Acta Biomedica Scientifica 3, no. 6 (2019): 15–22. http://dx.doi.org/10.29413/abs.2018-3.6.2.

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Stress reaction of the organism is a process occurring at the cellular, tissue and systemic levels. The organism responds to any adverse effect with a multi-level reaction, which causes the development of stress and, as a result, adaptation. The damaging effect is due to the excessive strengthening of another adaptive effect – lipotropic, that increases the activity of phospholipases and the intensity of free radical oxidation of lipids through the catecholamines and protein kinases. The changes in the immune system during the adaptation stage are to maintain antigenic homeostasis of the inter

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Rebolledo, Daniela L., María José Acuña, and Enrique Brandan. "Role of Matricellular CCN Proteins in Skeletal Muscle: Focus on CCN2/CTGF and Its Regulation by Vasoactive Peptides." International Journal of Molecular Sciences 22, no. 10 (2021): 5234. http://dx.doi.org/10.3390/ijms22105234.

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The Cellular Communication Network (CCN) family of matricellular proteins comprises six proteins that share conserved structural features and play numerous biological roles. These proteins can interact with several receptors or soluble proteins, regulating cell signaling pathways in various tissues under physiological and pathological conditions. In the skeletal muscle of mammals, most of the six CCN family members are expressed during embryonic development or in adulthood. Their roles during the adult stage are related to the regulation of muscle mass and regeneration, maintaining vasculariza

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Odintsova, Irina A., Tatyana I. Berezovskaya, and Dina R. Slutskaya. "Telocytes and pathological histogenesis." Bulletin of the Russian Military Medical Academy 26, no. 3 (2024): 437–46. http://dx.doi.org/10.17816/brmma626979.

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The ultramicroscopic structure of telocytes and their role in various pathologies were considered based on the analysis of scientific materials contained in eLibrary.Ru, The Russian National Library, and PubMed. Telocytes are cells of mesodermal, origin which are part of polydifferon loose connective tissue. Characteristically, they have long processes called telopods, which form a network by connecting them to the surrounding tissue elements. They are also found in the composition of musculoskeletal regenerates and near some tissue stem and progenitor cells. Such an arrangement may be associa

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Prusakov, A. V., Y. Yu Barteneva, and A. V. Yashin. "Microstructural organization of the mammary gland of the black mottle breed cows during the dry period." Legal regulation in veterinary medicine, no. 3 (October 19, 2022): 104–6. http://dx.doi.org/10.52419/issn2782-6252.2022.3.104.

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During the dry period, the udder tissues are renewed, which is necessary for subsequent lactation. According to many researchers, this period is the most favorable for the treatment and prevention of mastitis. The literature data concerning the microscopic organization of breast tissues in the dry period are sketchy and do not allow us to recreate a complete picture of its architectonics, which is necessary for understanding the physiological processes of lactation, as well as the competent organization of treatment and prevention of mastitis. Taking into account the above, we set a goal – to

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Anandagoda, Nelomi, Daniel G. Ezra, Umber Cheema, Maryse Bailly, and Robert A. Brown. "Hyaluronan hydration generates three-dimensional meso-scale structure in engineered collagen tissues." Journal of The Royal Society Interface 9, no. 75 (2012): 2680–87. http://dx.doi.org/10.1098/rsif.2012.0164.

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Here, we show that the local incorporation of osmotically active hyaluronan into previously compressed collagen constructs results in further rapid dehydration/compression of collagen layers, channel formation and generation of new interfaces; these novel structures, at the nano–micro (i.e. meso-scale) were formed within native collagen gels, in a highly predictable spatial manner and offer important new methods of fabricating scaffolds (e.g. tubes and open-spirals) with potential for use in tissue regeneration such as in peripheral nerves and small vessels. This paper tests the possibility th

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Saryeva, Olga P., Aleksej P. Vahromeev, and Violetta V. Parejshvili. "Pregnancy and delivery in women with undifferentiated connective tissue dysplasia: clinical and morphological aspects." I.P. Pavlov Russian Medical Biological Herald 29, no. 1 (2021): 99–108. http://dx.doi.org/10.23888/pavlovj202129199-108.

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Aim. This study aimed to identify peculiarities of the course of pregnancy, delivery, and morphology of the placenta in women with undifferentiated connective tissue dysplasia (UCTD). Materials and Methods. The main group included 60 pregnant women with UCTD, and the control group was composed of 30 somatically healthy women with physiological course of pregnancy. All patients were examined as regards the use of general clinical and laboratory methods. Moreover, 65 placentas were subjected to complex morphological examinations, including organometry, macro- and microscopic examinations,

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18

de JONG-BRINK, M., M. BERGAMIN-SASSEN, and M. SOLIS SOTO. "Multiple strategies of schistosomes to meet their requirements in the intermediate snail host." Parasitology 123, no. 7 (2001): 129–41. http://dx.doi.org/10.1017/s0031182001008149.

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The results of the studies on our model combination Trichobilharzia ocellata–Lymnaea stagnalis, presented in this review, lead to the conclusion that schistosomes use multiple strategies to reach their goals, i.e. to propagate and to continue their life cycle. They have to escape from being attacked by the internal defence system (IDS) of the snail host and to profoundly affect the host's energy flow, of which reproduction and growth are the main determinants, for their own benefit. These physiological changes they establish mainly by interfering with the two regulatory systems in the snail ho

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Милькевич, I. Milkevich, Гусейнов, A. Guseynov, Гусейнов, and T. Guseynov. "Anatomical and physiological aspects of lactostasis." Journal of New Medical Technologies 21, no. 3 (2014): 149–52. http://dx.doi.org/10.12737/5923.

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Lactose is a consequence of dysfunction of the mammary glands in women with breastfeeding between production and secretion of milk, resulting in stagnation of milk. The purpose is to study predisposing anatomical and physiological factors in the de-velopment of lactose associated with narrowing of the ducts and hypofunction lobular-ductal system of the breast in women with breastfeeding. The research has included a study of the status of the lactating breast in 42 women with breastfeeding. The 1st group consisted of 27 women with lactose. Control (the 2nd) group consisted of 15 women with brea

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Collen, D., and H. R. Lijnen. "Matrix Metalloproteinase System Deficiencies and Matrix Degradation." Thrombosis and Haemostasis 82, no. 08 (1999): 837–45. http://dx.doi.org/10.1055/s-0037-1615920.

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IntroductionMatrix metalloproteinases (MMPs) constitute a tightly regulated family of enzymes that degrade most components of the extracellular matrix. They are classified based on substrate specificity. Collagenases (MMP-1, interstitial collagenase, EC 3.4.24.7; MMP-8, neutrophil collagenase, EC 3.4.24.34; MMP-13, collagenase-3) degrade connective tissue collagens. Gelatinases (MMP-2, gelatinase A, EC 3.4.24.24; MMP-9, gelatinase B, EC 3.4.24.35) degrade collagen types IV, V, VII and X, elastin, and denatured collagens. Stromelysins (MMP-3, stromelysin-1, EC 3.4.24.17; MMP-10, stromelysin-2,

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Fede, Caterina, Carmelo Pirri, Chenglei Fan, et al. "A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae." International Journal of Molecular Sciences 22, no. 3 (2021): 1411. http://dx.doi.org/10.3390/ijms22031411.

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The fascia can be defined as a dynamic highly complex connective tissue network composed of different types of cells embedded in the extracellular matrix and nervous fibers: each component plays a specific role in the fascial system changing and responding to stimuli in different ways. This review intends to discuss the various components of the fascia and their specific roles; this will be carried out in the effort to shed light on the mechanisms by which they affect the entire network and all body systems. A clear understanding of fascial anatomy from a microscopic viewpoint can further eluc

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Belova, Svetlana V., Roman A. Zubavlenko, Ekaterina V. Gladkova, Irina V. Babushkina, and Vladimir Yu Ul'yanov. "Free Radical Oxidation and Metabolic Processes of Cartilage and Bone Tissues in Animals with Surgical Model of Posttraumatic Osteoarthrosis." I.P. Pavlov Russian Medical Biological Herald 31, no. 2 (2023): 177–84. http://dx.doi.org/10.17816/pavlovj111575.

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INTRODUCTION: Posttraumatic osteoarthrosis (PTOA) resulting from injuries of connective-tissue components of the joint, is accompanied by formation of free radicals activating chondro- and osteoresorption, which leads to fragmentation of biopolymers of the extracellular matrix of the joint tissues. AIM: To study the peculiarities of free radical oxidation and metabolic processes of cartilage and bone tissues in animals with a surgical model of PTOA of the knee joint. MATERIALS AND METHODS: The study was conducted on 31 rats (11 intact animals and 20 animals with PTOA model). The me

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Yang, Chun, Yi-kuan Du, Jian-bin Wu, et al. "Fascia and Primo Vascular System." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/303769.

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The anatomical basis for the concept of acupuncture points/meridians in traditional Chinese medicine (TCM) has not been resolved. This paper reviews the fascia research progress and the relationship among acupuncture points/meridians, primo vascular system (PVS), and fascia. Fascia is as a covering, with common origins of layers of the fascial system despite diverse names for individual parts. Fascia assists gliding and fluid flow and holds memory and is highly innervated. Fascia is intimately involved with nourishment of all cells of the body, including those of disease and cancer. The human

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Camus, G., G. Deby-Dupont, C. Deby, A. Juchmès-Ferir, J. Pincemail, and M. Lamy. "Inflammatory response to strenuous muscular exercise in man." Mediators of Inflammation 2, no. 5 (1993): 335–42. http://dx.doi.org/10.1155/s0962935193000468.

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Based on the humoral and cellular changes occurring during strenuous muscular work in humans, the concept of inflammatory response to exercise (IRE) is developed. The main indices of IRE consist of signs of an acute phase response, leucocytosis and leucocyte activation, release of inflammatory mediators, tissue damage and cellular infiltrates, production of free radicals, activation of complement, and coagulation and fibrinolytic pathways. Depending on exercise intensity and duration, it seems likely that muscle and/or associated connective tissue damage, contact system activation due to shear

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Lutsenko, Svetlana, Natalie L. Barnes, Mee Y. Bartee, and Oleg Y. Dmitriev. "Function and Regulation of Human Copper-Transporting ATPases." Physiological Reviews 87, no. 3 (2007): 1011–46. http://dx.doi.org/10.1152/physrev.00004.2006.

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Copper-transporting ATPases (Cu-ATPases) ATP7A and ATP7B are evolutionarily conserved polytopic membrane proteins with essential roles in human physiology. The Cu-ATPases are expressed in most tissues, and their transport activity is crucial for central nervous system development, liver function, connective tissue formation, and many other physiological processes. The loss of ATP7A or ATP7B function is associated with severe metabolic disorders, Menkes disease, and Wilson disease. In cells, the Cu-ATPases maintain intracellular copper concentration by transporting copper from the cytosol acros

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Moskalev, A. V., B. Yu Gumilevskiy, A. V. Apchel, and V. N. Tsygan. "Stem cells and their physiological effects." Bulletin of the Russian Military Medical Academy 21, no. 4 (2019): 172–80. http://dx.doi.org/10.17816/brmma630092.

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The characteristic of various populations stem cells is presented. Their physiological features are examined: differentiations, dedifferentiation, transdifferentiation, plasticity, and also the factors promoting their display. The comparative characteristic embryonic and somatic stem cells which are closest to practical application is received broad covarage. It is shown, that embryonic stem cells are differentiated in three various types of tissue: endoderm, giving rise to internal bodies, mesoderm from which develops connecting, muscular and bone tissue, and also the system of blood circulat

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Lozano, Julio Cesar Martinez, Rosa Margarita Gomez, Andres Gabriel Zarate Sanabria, Giovanny Jubiz, and Sonia Del Pilar Otalora Valderrama. "Genetic Aspects of Glial Cells Regarding Neurodegenerative Diseases." Current Pharmaceutical Design 24, no. 15 (2018): 1727–35. http://dx.doi.org/10.2174/1381612823666170828134055.

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Glial cells (also known as glia or neuroglia) are structures which are found in large numbers throughout the nervous system, fulfilling multiple functions, such as regulating the synapses, providing structure, support and nutrition, contributing towards the immune response and tissue oxygenation. Knowledge regarding glial cells has increased during the last few years, since Virchow defined them as supporting connective tissue, followed by Ramón y Cajal who described them as tissue in themselves, until today when a first order physiological role has been recognised for them and a leading role i

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Yung, Kaung-Ti. "A Birdcage Model for the Chinese Meridian System Part V: Applications to Animals and Plants." American Journal of Chinese Medicine 33, no. 06 (2005): 903–12. http://dx.doi.org/10.1142/s0192415x05003491.

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Since we all belong to the Kingdom Animalia, it is not surprising that animals in general benefit from the healing art of acupuncture that helps humans. Consequently, any proposed mechanism of Qi and acupuncture for humans based on animal physiology is probably applicable to animals as well, yet none is capable of explaining most of the complicated physiological effects observed. Not much attention was paid to the effects of Qi and acupuncture on plants (Kingdom Plantae) and on enoki mushrooms (Kingdom Fungi) by the TCM community, probably because they cannot be explained in terms of neurochem

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Hejran, Abdul Bari, Hafizullah Ashrafi, Abdul Qadeer Baseer, et al. "The Importance of Hyaluronic Acid in Biological Systems." European Journal of Theoretical and Applied Sciences 2, no. 2 (2024): 730–43. http://dx.doi.org/10.59324/ejtas.2024.2(2).65.

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Hyaluronic acid (HA) is a crucial component of the extracellular matrix, found abundantly in connective tissues, skin, and synovial fluid. Its unique properties, including hydration capacity and viscoelasticity, play pivotal roles in tissue hydration, lubrication, and wound healing. Despite its ubiquitous presence, the specific mechanisms underlying its diverse biological functions remain the subject of ongoing research. Studies have elucidated HA's involvement in various physiological processes, such as cell proliferation, migration, and differentiation. Its interaction with cell surface rece

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Abdul, Bari Hejran, Ashrafi Hafizullah, Qadeer Baseer Abdul, et al. "The Importance of Hyaluronic Acid in Biological Systems." European Journal of Theoretical and Applied Sciences 2, no. 2 (2024): 730–43. https://doi.org/10.59324/ejtas.2024.2(2).65.

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Hyaluronic acid (HA) is a crucial component of the extracellular matrix, found abundantly in connective tissues, skin, and synovial fluid. Its unique properties, including hydration capacity and viscoelasticity, play pivotal roles in tissue hydration, lubrication, and wound healing. Despite its ubiquitous presence, the specific mechanisms underlying its diverse biological functions remain the subject of ongoing research. Studies have elucidated HA's involvement in various physiological processes, such as cell proliferation, migration, and differentiation. Its interaction with cell surface rece

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Cronin, M. J., and T. Malaska. "Characterization of relaxin-stimulated cyclic AMP in cultured rat anterior pituitary cells: influence of dopamine, somatostatin and gender." Journal of Molecular Endocrinology 3, no. 3 (1989): 175–82. http://dx.doi.org/10.1677/jme.0.0030175.

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ABSTRACT Relaxin is a hormone associated with pregnancy that relaxes uterine smooth muscle and softens the connective tissues of the cervix and pelvis. In spite of these well-characterized tissue responses, the second messenger system linked to the relaxin receptor and the range of target tissues are only modestly understood. We found that relaxin enhanced the cyclic AMP levels in anterior pituitary cells from adult female rats. Relaxin induced a maximal 5·7±0·5-fold (mean±s.e.m.) stimulation of cyclic AMP accumulation and had an excitatory concentration for half maximal effect (EC50) of 0·4±0

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Bhattacharya, Sarbani, Victoria A. Ploplis, and Francis J. Castellino. "Bacterial Plasminogen Receptors Utilize Host Plasminogen System for Effective Invasion and Dissemination." Journal of Biomedicine and Biotechnology 2012 (2012): 1–19. http://dx.doi.org/10.1155/2012/482096.

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In order for invasive pathogens to migrate beyond the site of infection, host physiological barriers such as the extracellular matrix, the basement membrane, and encapsulating fibrin network must be degraded. To circumvent these impediments, proteolytic enzymes facilitate the dissemination of the microorganism. Recruitment of host proteases to the bacterial surface represents a particularly effective mechanism for enhancing invasiveness. Plasmin is a broad spectrum serine protease that degrades fibrin, extracellular matrices, and connective tissue. A large number of pathogens express plasminog

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Zhou, Fengfang, Binxin Cai, Shaojiang Ruan, Liangyin He, Weiqing Huang, and Qi Wei. "Effects of Low Salinity on the Physiological Indices, Stress-Related Gene Expression, and Histological Changes in Phasolosma Esculenta." Current Topics in Nutraceutical Research 20, no. 4 (2022): 603–9. http://dx.doi.org/10.37290/ctnr2641-452x.20:603-609.

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Acute saline stress can cause death of Phasolosma esculenta, an important aquaculture species in China. Hence, investigating the sensitivity and physiological responses of P. esculenta to saline stress is important. The molecular, physiological, and immune responses of the intestine and body wall of P. esculenta upon saline stress were investigated in this study. The mortality rate of P. esculenta increased with the decreasing salinity. The Na<sup>+</sup>/K<sup>+</sup>-ATPase and acid phosphatase activity peaked at 6 h and 12 h, respectively, in the intestine and body wall, and subsequently st

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Warner, Fiona J., John S. Lubel, Geoffrey W. McCaughan, and Peter W. Angus. "Liver fibrosis: a balance of ACEs?" Clinical Science 113, no. 3 (2007): 109–18. http://dx.doi.org/10.1042/cs20070026.

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There is an increasing body of evidence to suggest that the RAS (renin–angiotensin system) contributes to tissue injury and fibrosis in chronic liver disease. A number of studies have shown that components of a local hepatic RAS are up-regulated in fibrotic livers of humans and in experimental animal models. Angiotensin II, the main physiological effector molecule of this system, mediates liver fibrosis by stimulating fibroblast proliferation (myofibroblast and hepatic stellate cells), infiltration of inflammatory cells, and the release of inflammatory cytokines and growth factors such as TGF

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Kryzhanivska, O. O. "IRIS CHANGES AT PATIENTS WITH TEMPORОMANDIBULAR JOINT DISEASES AND URINARY SYSTEM PATHOLOGY". Medical Science of Ukraine (MSU) 16, № 4 (2020): 28–34. http://dx.doi.org/10.32345/2664-4738.4.2020.5.

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Relevance. In recent years, many have been devoted to the problem of the temporomandibular joint (TMJ) diseases, in which the attention is paid to the widespread pathology of TMJ in young people, which develops against the background of the genetically-determined weakness of connective tissue (CTs), which is also the present occurrence of various concomitant diseases of polygenic-multifactorial nature, including the organs of the urinary system (US). The study of the state of the iris is used as a screening technique that allows you to quickly, simply, harmlessly, informatively, painless

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López-Campos, Ó., J. L. Aalhus, J. Galbraith, et al. "The relation of carcass physiological maturity to meat quality in the Canadian Bison Grading System." Canadian Journal of Animal Science 94, no. 1 (2014): 55–62. http://dx.doi.org/10.4141/cjas2013-047.

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López-Campos, Ó., Aalhus, J. L., Galbraith, J., Larsen, I. L., Juárez, M., Uttaro, B. and Robertson, W. M. 2014. The relation of carcass physiological maturity to meat quality in the Canadian Bison Grading System. Can. J. Anim. Sci. 94: 55–62. A total of 119 bull (n=62) and heifer (n=57) bison carcasses were selected to determine the effectiveness of youthful to intermediate physiological maturity [ossification at the 9th/10th/11th thoracic spinous processes (≤50%; 51–65%; 66–80%)] range to accurately classify bison carcasses with respect to quality. Carcasses were classified into three maturi

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Jaśkiewicz, Łukasz, Grzegorz Chmielewski, Jakub Kuna, Tomasz Stompór, and Magdalena Krajewska-Włodarczyk. "The Role of Sclerostin in Rheumatic Diseases: A Review." Journal of Clinical Medicine 12, no. 19 (2023): 6248. http://dx.doi.org/10.3390/jcm12196248.

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Systemic connective tissue disorders constitute a heterogenous group of autoimmune diseases with the potential to affect a range of organs. Rheumatoid arthritis (RA) is a chronic, progressive, autoimmune inflammatory disease affecting the joints. Systemic lupus erythematosus (SLE) may manifest with multiple system involvement as a result of inflammatory response to autoantibodies. Spondyloarthropathies (SpAs) such as ankylosing spondylitis (AS) or psoriatic arthritis (PsA) are diseases characterised by the inflammation of spinal joints, paraspinal tissues, peripheral joints and enthesitis as w

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Sheu, Katherine M., and Alexander Hoffmann. "Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance." Annual Review of Immunology 40, no. 1 (2022): 295–321. http://dx.doi.org/10.1146/annurev-immunol-101320-031555.

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Macrophages are first responders for the immune system. In this role, they have both effector functions for neutralizing pathogens and sentinel functions for alerting other immune cells of diverse pathologic threats, thereby initiating and coordinating a multipronged immune response. Macrophages are distributed throughout the body—they circulate in the blood, line the mucosal membranes, reside within organs, and survey the connective tissue. Several reviews have summarized their diverse roles in different physiological scenarios and in the initiation or amplification of different pathologies.

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Sheu, Katherine M., and Alexander Hoffmann. "Functional Hallmarks of Healthy Macrophage Responses: Their Regulatory Basis and Disease Relevance." Annual Review of Immunology 40, no. 1 (2022): 295–321. http://dx.doi.org/10.1146/annurev-immunol-101320-031555.

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Macrophages are first responders for the immune system. In this role, they have both effector functions for neutralizing pathogens and sentinel functions for alerting other immune cells of diverse pathologic threats, thereby initiating and coordinating a multipronged immune response. Macrophages are distributed throughout the body—they circulate in the blood, line the mucosal membranes, reside within organs, and survey the connective tissue. Several reviews have summarized their diverse roles in different physiological scenarios and in the initiation or amplification of different pathologies.

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Poliyasnyi, V. O., and L. S. Kupriianova. "Immunuhistochemical features of the ovaries’ structure in case of fetuses with a gestational term of 21-28 weeks from mother, whose pregnancy was complicated by chronic infections of lower genital tracts." Journal of Education, Health and Sport 11, no. 5 (2021): 246–61. http://dx.doi.org/10.12775/jehs.2021.11.05.026.

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The following article presents results of the complex research on postulation of immunohistochemical features of the ovaries’ structure in case of fetuses with a gestational term of 21-28 weeks from mothers with HILGT comparing to ones in case of fetuses from mothers with a physiological pregnancy. The materials of the research are: 25 fetuses from mothers with HILGT as well as 25 fetuses from mothers with physiological pregnancy. All fetuses had died antenatally and inranatally, as a result of violation of uteroplacental and umbilical-uterine circulation. Research methods: macroscopic, organo

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Shang, Charles. "Prospective Tests on Biological Models of Acupuncture." Evidence-Based Complementary and Alternative Medicine 6, no. 1 (2009): 31–39. http://dx.doi.org/10.1093/ecam/nem122.

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The biological effects of acupuncture include the regulation of a variety of neurohumoral factors and growth control factors. In science, models or hypotheses with confirmed predictions are considered more convincing than models solely based on retrospective explanations. Literature review showed that two biological models of acupuncture have been prospectively tested with independently confirmed predictions: The neurophysiology model on the long-term effects of acupuncture emphasizes the trophic and anti-inflammatory effects of acupuncture. Its prediction on the peripheral effect of endorphin

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Trepat, Xavier, Zaozao Chen, and Ken Jacobson. "Cell Migration." Comprehensive Physiology 2, no. 4 (2012): 2369–92. https://doi.org/10.1002/j.2040-4603.2012.tb00467.x.

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AbstractCell migration is fundamental to establishing and maintaining the proper organization of multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell locomotion, from large‐scale migrations of epithelial sheets during gastrulation, to the movement of individual cells during development of the nervous system. In an adult organism, cell migration is essential for proper immune response, wound repair, and tissue homeostasis, while aberrant cell migration is found in various pathologies. Indeed, as our knowledge of migration increases, we can look forward to, for

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Tonkopei, Yuliia, Olha Skyba, Viktor Bondarenko, Tetiana Buhaienko, Yurii Kurnyshev, and Tetiana Liasota. "Determinants for Predicting Polyorganic Functional Changes of the Musculoskeletal System in Children with Various Degrees of Joints Hypermobility." Acta Balneologica 65, no. 1 (2023): 31–35. http://dx.doi.org/10.36740/abal202301105.

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Aim: The aim of the work was to study the presence of determinants for predicting the local structures involvement of the musculoskeletal system against the background of joint hypermobility in children. Materials and Methods: The study involved 446 children aged from four to six years. The study plan includes: copying the data of a comprehensive medical examination; determination of joint hypermobility by goniometry and evaluation according to the criteria of presence and degree of joint hypermobility by the method of C. Carter, J. Wilkinson – in the modification of P. Beighton; application o

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Lu, Emily Ming-Chieh. "Three-Dimensional Organotypic Systems for Modelling and Understanding Molecular Regulation of Oral Dentogingival Tissues." International Journal of Molecular Sciences 25, no. 21 (2024): 11552. http://dx.doi.org/10.3390/ijms252111552.

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Three-dimensional organotypic models benefit from the ability to mimic physiological cell–cell or cell–matrix interactions and therefore offer superior models for studying pathological or physiological conditions compared to 2D cultures. Organotypic models consisting of keratinocytes supported by fibroblasts embedded in collagen matrices have been utilised for the study of oral conditions. However, the provision of a suitable model for investigating the pathogenesis of periodontitis has been more challenging. Part of the complexity relates to the different regional epithelial specificities and

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Erlich, Stephanie S., J. Gordon McComb, Shigeyo Hyman, and Martin H. Weiss. "Ultrastructural morphology of the olfactory pathway for cerebrospinal fluid drainage in the rabbit." Journal of Neurosurgery 64, no. 3 (1986): 466–73. http://dx.doi.org/10.3171/jns.1986.64.3.0466.

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✓ Previous physiological studies indicate that the olfactory region serves as a major pathway for cerebrospinal fluid (CSF) drainage into the lymphatic system. The present study was undertaken to determine the ultrastructural characteristics of this egress route. New Zealand White rabbits received a single bolus injection of the tracer ferritin (MW 400,000) into both lateral ventricles in such a manner as not to raise the intraventricular pressure above the normal level. The animals were sacrificed via intracardiac perfusion of fixative between less than 12 minutes and 4 hours following inject

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Wang, Xiaopu, Junyu Pei, and Xinqun Hu. "The Brain-Heart Connection in Takotsubo Syndrome: The Central Nervous System, Sympathetic Nervous System, and Catecholamine Overload." Cardiology Research and Practice 2020 (March 9, 2020): 1–5. http://dx.doi.org/10.1155/2020/4150291.

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Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when prese

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Prokhorova, O. V., A. A. Olina, G. Kh Tolibova, and T. G. Tral. "Peptide hormone relaxin: from molecular effects to clinical results." Ural Medical Journal 20, no. 1 (2021): 89–96. http://dx.doi.org/10.52420/2071-5943-2021-20-1-89-96.

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Introduction. The peptide hormone relaxin, which is produced by cells of the corpus luteum during and outside pregnancy, has a huge number of clinically significant effects, mediating many biological mechanisms, including antifibrotic, vasodilatory, angiogenic, anti-inflammatory and antiapoptotic effects.Purpose of the study: based on the study of modern literature data, to analyze the results of scientific research, representing the current system of views on the physiological and pathophysilogical effects of relaxin.Materials and methods. A study f scientific publications for the period from

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Maiorano, Giuseppe. "Meat defects and emergent muscle myopathies in broiler chickens: implications for the modern poultry industry." Roczniki Naukowe Polskiego Towarzystwa Zootechnicznego 13, no. 3 (2017): 43–51. http://dx.doi.org/10.5604/01.3001.0010.5454.

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- Due to intensive selection, broiler chickens have become the most efficient meat producing animals, attaining exceptionally rapid growth. However, several studies indicate that fast-growing varieties exhibit various muscle tissue defects – myopathies – which adversely affect the poultry meat industry. In particular, recent decades have seen an increase in the incidence of breast muscle abnormalities such as myopathy of the minor (deep) pectoral muscles and pale, soft and exudative (PSE) meat, and more recently white fibres called ‘white striping’, hardening of the breast muscle known as ‘woo

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Gonçalves, Cátia F., and Qing-Jun Meng. "Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis." Journal of Endocrinology 243, no. 3 (2019): R29—R46. http://dx.doi.org/10.1530/joe-19-0256.

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The circadian system in mammals is responsible for the temporal coordination of multiple physiological and behavioural processes that are necessary for homeostasis. In the skeleton, it has long been known that metabolic functions of chondrocytes, osteoblasts and osteoclasts exhibit intrinsic circadian rhythms. In addition, results from animal models reveal a close connection between the disruption of circadian rhythms and skeletal disorders such as rheumatoid arthritis, osteoarthritis and osteoporosis. In this review, we summarise the latest insights into the genetic and biochemical mechanisms

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Huang, Zhenhua, Linda Taylor, Bin Liu, Jun Yu, and Peter Polgar. "Modulation by bradykinin of angiotensin type 1 receptor-evoked RhoA activation of connective tissue growth factor expression in human lung fibroblasts." American Journal of Physiology-Lung Cellular and Molecular Physiology 290, no. 6 (2006): L1291—L1299. http://dx.doi.org/10.1152/ajplung.00443.2005.

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The mechanisms regulating the opposing physiological actions of bradykinin (BK) and angiotensin II (AngII) are not well understood. Here we investigate signaling interactions between these two effectors. Connective tissue growth factor (CTGF) expression in IMR-90, human lung fibroblasts, is used as the endpoint target. In these cells the BK B2 receptor (BKB2R) is expressed constitutively, while no binding of AngII is detected. An inducible expression system is used to insert AngII receptor 1 (AT1R) and to obtain a signal level in response to AngII at the magnitude of BK. AngII and BK activate

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