Relevant bibliographies by topics / Physiology (medical) / Dissertations / Theses
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Dissertations / Theses on the topic 'Physiology (medical)'

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Published: 9 July 2021
Last updated: 25 July 2025

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1

Edlund, Måns. "Aspects on menstrual physiology, pathology and medical treatment of menorrhagia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-669-3/.

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2

Alonso, Ortiz Eva. "Quantitative functional MRI based evaluation of caffeine's effects on brain physiology." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106308.

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The blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal is one of the most recently developed imaging techniques used to identify localized changes in brain activity. The BOLD signal is a function of cerebral blood flow (CBF), the cerebral metabolic rate of oxygen consumption (CMRO2), and cerebral blood volume (CBV). Normally coupled changes in these physiological parameters during regional increases in neural activity will result in BOLD signal increases. This makes the BOLD signal useful as a tool for identifying areas of increased neural activity. Moreove
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3

Palmer, Gary Stanley. "Physiological and metabolic responses to constant and variable load cycling performance." Doctoral thesis, University of Cape Town, 1999. http://hdl.handle.net/11427/26920.

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The experiments described in this thesis comprise a series of related, yet independent investigations examining the physiological and metabolic responses of well-trained amateur cyclists under conditions designed to mimic actual competitive situations, during individual and mass start races. In Section A the physiological responses to constant load and steady state exercise are determined. In Section B, the metabolic factors associated with constant and variable load cycling performance are examined.
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4

Rapuling, Llewelen. "Proteomic analysis of human sperm proteins in relation to sperm motility, morphology and energy metabolism." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5205.

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Bibliography<br>Thesis (MScMedSc (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: Male infertility is often associated with impaired sperm motility and morphology (asthenoteratozoospermia) for which there is no specific therapeutic treatment. It has come to light that the modification and expression of human sperm proteins play a crucial role in sperm function. In the present study, we present proteomic data of human spermatozoa in the context of sperm dysfunction. Novel techniques have been used to successfully isolate and identify differ
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5

Hawley, John Alan. "Limits to exogenous glucose oxidation by skeletal muscle during prolonged, moderate-intensity exercise in man." Doctoral thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/27121.

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Several factors may determine the rate. at which exogenous carbohydrate (CHO) is utilised by the human working muscles during prolonged (> 90 min moderate-intensity (63% of peak sustained power output [PPO]) exercise. These include i) the rate of gastric emptying of an ingested fluid, ii) the rate of digestion, absorption and subsequent transport of glucose into the systemic circulation, and iii) the rate of glucose uptake and oxidation by the working muscles. To test the hypothesis that the rate of gastric emptying is the primary factor limiting the rate of CHO delivery to the working muscles
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6

Brown, Patrick J. P. "Anatomy and Physiology: A Guided Inquiry." Digital Commons @ East Tennessee State University, 2015. http://amzn.com/1119175259.

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Students Learn when they are actively engaged and thinking in class. The activities in this book are the primary classroom materials for teaching Anatomy and Physiology, sing the POGIL method. The result is an "I can do this" attitude, increased retention, and a feeling of ownership over the material.<br>https://dc.etsu.edu/etsu_books/1027/thumbnail.jpg
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7

Kim, Kristin. "Characterization of calcium binding protein 1 (CaBP1/CD) expression and localization in the mouse brain." Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/2545.

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Ca2+-binding proteins (CaBP) alter Ca2+ signals, triggering cellular processes such as gene transcription regulation in neurons. CaBP1/CD is a calmodulin (CaM)-like Ca2+ binding protein that may regulate neuronal functions through interactions with effectors such as voltage-gated Ca2+ (Cav) channels and inositol trisphosphate receptors (InsP3Rs). To gain insight into the potential cellular functions of CaBP1/CD, we analyzed the expression and localization of CaBP1/CD variants in mouse brain. Of the three CaBP1/CD splice variants that have been characterized (CaBP1-S, CaBP1-L, and caldendrin (C
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8

Newton, Michael John. "The Relationship Between Functional And Histological Changes In Muscle Following Eccentric Exercise In Mice." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2000. https://ro.ecu.edu.au/theses/1529.

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Exercise-induced muscle damage (EIMD) is known to be produced by novel or unaccustomed exercise, especially high force eccentric contractions. Histological myofibre disruption, force loss and muscle soreness are associated with EIMD and have implications for sporting performance. Traditional practices of assessing the extent of disruption to the myofibres is by performing needle biopsies and subsequently analysing the histology of the fibres. Recently there has been interest in investigating whether changes in force production and contractile properties of muscle following damaging exercise co
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9

Faure, Jacqueline Jeanette. "A proteomic and neurochemical analysis of the effects of early life stress on drug addiction and post abuse therapeutic interventions : an animal study." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/3189.

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Thesis (PhD (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: Psychosocial stressors have frequently been associated with an increased risk for developing The contributions of the cholinergic (Lobeline) and opioid (Naltrexone) systems in place preference behaviour were determined by employing a post-methamphetamine pharmacological treatment strategy. These two treatments failed to reverse the methamphetamine-induced place preference. However, administration of the drugs did lead to alterations in striatal dopamine and serotonin levels which
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10

Weston, Adele Robyn. "Selected exercise and skeletal muscle characteristics of African distance runners." Doctoral thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26560.

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African runners dominate distance running both in South Africa and internationally. Therefore, the aim of this thesis was to compare selected exercise and skeletal muscle characteristics in well-trained African and Caucasian 10 km runners to determine if evidence exists of differences between these groups with respect to these physiological and biochemical characteristics. Furthermore, the relationship between exercise and skeletal muscle characteristics was investigated. Sedentary individuals from each population group were also studied to determine if differences existed in untrained skeleta
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11

Weltan, Sandra Mary. "The effect of muscle glycogen status on control of substrate metabolism during exercise." Doctoral thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/26559.

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Glycogen depletion has frequently been shown to result in a decrease in respiratory exchange ratio (RER). However, the metabolic response to glycogen depletion has generally been studied in overnight fasted subjects or in subjects who were already fatigued, or hypoglycaemic, or both, raising the question of whether the differences seen were due to general "carbohydrate deficiency" or due specifically to muscle or liver glycogen depletion. If euglycaemia and especially hyperglycaemia is maintained, the " carbohydrate deficiency" is overcome. In addition, because insulin stimulates muscle glucos
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12

Asadipour, Ali. "A technology-aided multi-modal training approach to assist abdominal palpation training and its assessment in medical education." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/77668/.

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Kinaesthetic Learning Activities (KLA) are techniques for enhancing the motor learning process to provide a deep understanding of fundamental skills in particular disciplines. With KLA learning takes place by carrying out a physical activity to transform empirical achievements into representative cognitive understanding. In disciplines such as medical education, frequent hands-on practice of certain motor skills plays a key role in the development of medical students' competency. Therefore it is essential that clinicians master these core skills early on in their educational journey as well as
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13

Shah, Sneha. "Risperidone and its Deconstructed Analogs: Functional Effects on the 5HT2AR." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3792.

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G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways. The serotonin 5HT2A receptor (or 2AR) is one of the GPCRs coupled to Gq proteins, activating PLC and hydrolyzing PIP2. This hydrolysis causes a diffusion of bound PIP2 away from the channel binding site resulting in G protein-gated inwardly rectifying K+ channel (GIRK) inhibition and a downstream stimulation of Ca2+ release from endoplasmic reticulum stores. Previous experiments have demonstrated that the serotonin 5HTA receptor is a target
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14

Chellan, Nireshni. "The effect of Cyclopia maculata extract on β-cell function, protection against oxidative stress and cell survival". Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95861.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Insights into the role of oxidative stress and pancreatic β-cell dysfunction in the pathogenesis of type 2 diabetes (T2D) reveals an opportunity for the development of novel therapeutics that directly protect and preserve β-cells. The protective role of dietary antioxidants, such as plant polyphenols, against oxidative stress induced diseases, including T2D, is increasingly under scrutiny. Polyphenol-rich extracts of Cyclopia spp, containing mangiferin, may provide novel therapeutics. An aqueous extract of unfermented Cyclopia m
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15

Loubser, Dirk Jacobus. "Nitric oxide and the endothelium : characterisation of in vitro nitric oxide detection techniques and an ex vivo method of measuring endothelial function." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86496.

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Thesis (MScMedSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Introduction: Nitric oxide (NO) is an important chemical messenger in the cardiovascular system. Despite considerable progress in this field, there remains an on-going need for affordable and user-friendly NO measurement techniques. Therefore, in this study we aimed to develop and characterise NO-detection techniques not previously used in our laboratory, and, in addition, characterise an ex vivo method to measure the functional effects of the endothelium and NO production in the vasculature. Methods: Three different
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16

Hattingh, Susanna Maria (Suzel). "Ischaemic preconditioning : an investigation of the patterns of kinase activation and protein expression profiles during reperfusion in the rat heart." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85789.

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Thesis (PhD)--Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Introduction: Coronary heart disease (CHD) is the leading cause of death worldwide with 3.8 million men and 3.4 million women dying globally each year. Although existing myocardial reperfusion strategies such as thrombolysis and percutaneous coronary intervention (PCI), if applied in a timely manner, limit myocardial infarct size, the mortality and morbidity remains significantly high. Ischaemic preconditioning (IPC) may offer the potential to attenuate myocardial ischaemia/reperfusion injury through cardioprotective signa
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17

Bosch, Andrew Norman. "The effect of carbohydrate-loading and carbohydrate ingestion on fuel substrate kinetics during prolonged cycling." Doctoral thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/26557.

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It has been well established that both carbohydrate-loading before and carbohydrate ingestion during exercise can enhance endurance performance by supplying carbohydrate for oxidation. However, the precise mechanism(s) underlying the proposed ergogenic effects of these procedures remain to be established. The studies in this thesis were therefore designed to examine the effects of carbohydrate-loading and carbohydrate ingestion on fuel substrate kinetics.
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18

Smith, Wayne. "The impact of obesity and chronic PPAR Alpha agonist treatment on cardiac function, metabolism and ischaemic tolerance." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20351.

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Thesis (PhD)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Background: Myocardial oxidative fuel supply is increased in obese conditions. How this metabolic environment and altered cardiometabolic phenotype associated with prediabetic obesity impacts on cardiac function and tolerance to ischaemia/reperfusion injury remains uncertain. While obese individuals are likely to be treated with PPARα agonists, controversy exists as to how activation of the PPARα receptor influences cardiovascular function and post-ischaemic recovery. Aims: To determine in a model of hyperphagia-induced o
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19

Filippone, Scott M. "Inhibition of mTOR Signaling Protects Against Myocardial Reperfusion Injury, Acute Myocardial Infarction." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3847.

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Acute myocardial infarction (AMI) is the leading cause of death worldwide. Currently, the best method of treating cardiac ischemia is early reperfusion which, itself, induces myocardial damage. The mTOR complex is a key regulator of cardioprotection against cell stressors. We hypothesized that reperfusion therapy with Rapamycin, a potent mTOR inhibitor, would reduce infarct size in adult mouse hearts. Rapamycin was administered at the onset of reperfusion following 30 min in situ LAD ligation. After 24 hours of reperfusion, myocardial infarct size and apoptosis were significantly reduced in ra
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20

Beck, Jennifer 1968. "Effects of chest wall configuration and electrode positioning on human diaphragmatic EMG." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22536.

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The measurement and analysis of the human diaphragm electromyogram (EMGdi), as obtained with an esophageal electrode, requires objective control of the disturbances and filtering effects which can influence the signal. One issue of importance is that an increase in the muscle-to-electrode distance (MEdist) acts as a low-pass filter, filtering out the high frequency components of the EMG power spectrum (the MEdist filter). Due to the numerous factors which can influence the EMGdi, control of signal quality is also of utmost importance. The aims of this study were: (1) to evaluate the effect of
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21

Krogh-Madsen, Trine. "Effects of single-channel noise on spontaneous beating and the phase-resetting response of cardiac oscillators." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85562.

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From our everyday life, we know that our hearts beat with a rhythm which is not perfectly periodic. Even an isolated spontaneously beating cardiac cell, devoid of neural, hormonal, and intracardiac regulatory input, does not beat perfectly regularly. I investigate the hypothesis that the beat-to-beat fluctuations in transmembrane potential of spontaneously beating cardiac cells are due to stochastic gating of the ionic channels in the cell membrane.<br>Recordings of transmembrane potential from small clusters of spontaneously beating 7-day-old embryonic chick ventricular cells were analy
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22

Pienaar, Ilse-Sanet. "The impact of developmental stress on the functioning and vulnerability of CNS neurons." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1218.

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Thesis (PhD (Biomedical Sciences. Medical Physiology))--Stellenbosch University, 2008.<br>The overall objective of this thesis is to provide additional data to assist clinicians and experimental neurologists alike in the quest for better understanding, more accurately diagnosing and more successfully treating patients suffering from Parkinson’s disease (PD). The general theme of the thesis is the interaction between certain environmental stimuli, including the exposure to adverse events during early central nervous system (CNS) development and the manifestation of elements of neurodegener
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23

Haubert, Lisa Marie. "Surgical Clinical Correlates in Anatomy: Implementation of a First-Year Medical School Program." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253374287.

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24

Divljak, Gordan. "Muscular strength and power development to high and low resistance loads in trained individuals. : 8-week intervention." Thesis, Gymnastik- och idrottshögskolan, GIH, Institutionen för idrotts- och hälsovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-4911.

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Aim The purpose of this study was to examine high versus low resistance training loads performed to muscular failure and its effect on muscular strength, power and strength endurance. Method 11 men and 3 women (age 26,4 ±4,4 years, weight 79,9 ±10,7 kg, height 179,4 ±76 cm) were recruited to train for 2 days/week for 8-weeks in the leg press and leg extension. One leg was randomly allocated to a high load (HL) program performing 3-5 reps and the other leg was allocated to the low load (LL) program, performing 20-25 reps. All sets were executed to muscular fatigue. The participants were measure
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Lubelwana, Hafver Tandekile. "The role of glycogen synthase kinase-3 (GSK-3) protein in the development of myocardial hypertrophy in a rat model of diet induced obesity and insulin resistance." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/20130.

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Thesis (MScMedSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Introduction: The worldwide escalation in the incidence of obesity and its strong association with insulin resistance, type 2 diabetes and the cardiovascular complications that accompany these disease states have elicited interest in the underlying mechanisms of these pathologies. Preliminary data generated in our laboratory showed that obesity is associated with abnormalities in the insulin signalling pathway. Specifically, we found a down-regulation of protein kinase B (PKB/Akt), which is known to mediate the metabol
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Hill, Cindy. "The efficacy of Diavite tm (Prosopis glandulosa) as anti-diabetic treatment in rat models of streptozotocin-induced type 1 diabetes and diet-induced-obese insulin resistance." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/4173.

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Thesis (MScMedSc (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: Introduction: Obesity and its associated complications, such as the metabolic syndrome, hypertension and cardiovascular disease, are escalating worldwide. In recognition of this, untested remedies advertised as anti-diabetic agents are flooding the market. Many of these products have limited efficacy, limited tolerability and significant side-effects. One remedy, claiming to have anti-diabetic properties, is DiaviteTM. DiaviteTM, a herbal product, consisting solely of the dried a
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Mudau, Mashudu. "Endothelial dysfunction in cardiac microvascular endothelial cells : an investigation into cellular mechanisms and putative role of oleanolic acid in reversing endothelial dysfunction." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/5297.

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Thesis (MScMedSc (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: Introduction: The discovery of the endothelium as a regulator of vascular tone, and the subsequent discovery of nitric oxide (NO) as the major endothelium-derived relaxing factor (EDRF), has opened up vast possibilities in the continued efforts to prevent and manage cardiovascular disease. Endothelial dysfunction (ED) is defined as reduced NO bioavailability and hence the reduced ability of the endothelium to maintain vascular homeostasis. ED represents the first, reversible step
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28

Vallance, J. T. "The physiology and pathology of Asclepiades of Bithynia : with an appendix containing a collection of the Testimonia." Thesis, University of Cambridge, 1986. https://www.repository.cam.ac.uk/handle/1810/273114.

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29

Diesel, Wayne Jonathan. "Factors limiting the exercise tolerance of patients with end-stage renal failure undergoing maintenance haemodialysis." Doctoral thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/26548.

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Exercise tolerance, measured as peak oxygen consumption (VO₂ peak), is very low in patients with end-stage renal failure undergoing maintenance haemodialysis. Due to their associated anaemia and low peak heart rates during maximal exercise it has been argued that the reduced blood oxygen carrying capacity and central cardiovascular limitations are primarily responsible for the poor exercise tolerance of these patients. However, others suggest that peripheral (skeletal muscle) limitations including impaired substrate utilization, muscle weakness caused by peripheral neuropathy and myopathy, mal
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30

Wilhelmsson, Niklas. "From basic science knowledge to clinical understanding." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-866-2/.

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31

Cotin, Stéphane. "Computer Based Interactive Medical Simulation ." Habilitation à diriger des recherches, Université des Sciences et Technologie de Lille - Lille I, 2008. http://tel.archives-ouvertes.fr/tel-00839511.

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La simulation médicale interactive sur ordinateur est une technologie révolutionnaire pour améliorer l'efficacité de nombreuses interventions médicales tout en réduisant le niveau de risque pour les patients. Bien que visant essentiellement l'apprentissage, ces simulations pourraient être utilisées, dans un futur proche, pour la planification d'interventions complexes ou même pour assister le praticien / clinicien dans la salle d'opération. Ce manuscrit présente une revue détaillée du domaine multi-disciplinaire de la simulation médicale, et illustre nos différentes contributions dans ce domai
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32

Fairbairn, Lorren R. "A proteomic analysis of the ventral and dorsal hippocampal brain areas of serotonin knockout rats." Thesis, Stellenbosch : Stellenbosch University, 2008. http://hdl.handle.net/10019.1/1771.

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Thesis (MScMedSc (Biomedical Sciences. Medical Physiology)--Stellenbosch University, 2008.<br>For many centuries, scientists have engaged in a theoretical debate concerning the etiology of mood disorders, with very few ancient scholars speculating about the importance of genetic factors and affective temperaments as factors in the etiology of depression. Mood, emotion and cognition have been shown to be modulated by the serotonergic midbrain raphe system; implicated in the pathogenesis of psychiatric disorders like those of the affective spectrum. Evidence from neuroscience, genetics, and
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Jones, Rowdy, Jacqueline C. Potter, Shannon C. Allenn, et al. "Striking differences in uromodulin excretion and expression, salt-sensitive hypertension, and renal injury in Dahl SS vs. BN and SS.BN1 consomic rats." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/123.

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Uromodulin (UMOD) is a protein made exclusively in the thick ascending limb. Clinical studies have demonstrated that rare missense mutations in UMOD result in autosomal dominant tubulointerstitial kidney diseases manifest by tubulointerstitial fibrosis (TIF), tubular cysts and a rapid progression to renal failure. In addition, several genome wide association studies reported that common single nucleotide polymorphisms in the UMOD gene are associated with an increased risk of chronic kidney disease (CKD) and hypertension. Interestingly, Dahl salt-sensitive (SS) rats exhibit many of the same pat
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Kaune, Galaz Heidy. "Elucidating mechanisms of premature ovarian failure using a transgenic mouse model." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:79b7cad9-fcf8-48ad-9ec0-0bb772d4edb4.

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Bard, Amanda E. "The Effectiveness of Resistance Exercises in the Management of Medial Tibial Stress Syndrome." Scholarship @ Claremont, 2013. http://scholarship.claremont.edu/scripps_theses/279.

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Medial tibial stress syndrome (MTSS) is a stress and overuse injury that presents as pain on the medial aspect of the lower two-thirds of the tibia. It is most often caused by repetitive actions on hard surfaces such as running, marching, and dancing. Individuals most affected by MTSS are runners, members of the military, dancers, and athletes that play soccer, volleyball and basketball. While MTSS has a relatively standard presentation of pain on the medial aspect of the tibia, it can occasionally be mistaken for other injuries such as stress fractures or compartment syndrome. If a diagnosis
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Fu, Weisi. "PROTEIN KINASE A AND EPAC MEDIATE CHRONIC PAIN AFTER INJURY: PROLONGED INHIBITION BY ENDOGENOUS Y1 RECEPTORS IN DORSAL HORN." UKnowledge, 2016. https://uknowledge.uky.edu/physiology_etds/31.

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Inflammation or nerve injury sensitizes several populations of nociceptive neurons in the dorsal horn of the spinal cord, including those that express the neuropeptide Y (NPY) Y1 receptor (Y1R). Our overall hypothesis is that after tissue or nerve injury, these Y1R-expressing neurons enter a state of latent sensitization (LS) that contributes to vulnerability to the development of chronic pain; furthermore, LS is under the tonic inhibitory control of endogenous Y1R signaling. First, we evaluated the intracellular signaling pathways that become activated in Y1R-expressing neurons and participat
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Youssef, May Mahmoud Ahmed Abdo. "Design and development of a medical device for treatment of proximal interphalangeal joint contracture." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6518/.

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The proximal Interphalangeal (PIP) joint is vital for hand function. It is frequently affected by contractures as a result of injury or disease. Dynamic external fixators are one of the useful treatment methods of these contractures, enabling the ability to exercise adjacent joints during healing. The aim of this study was a development of the Compass hinge device to present a new design device for the digit PIP joint. A failed Compass hinge external fixator has been analysed. The device consists of polymer parts manufactured from polyetherimide (PEI). Finite element analysis (FEA) was used to
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Shipton, Olivia Ashley. "Asymmetry of hippocampal function in mice : left-right differences in memory processing and vulnerability to amyloid beta." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:972d7dbf-fcf1-4f84-9a84-406418dbc7fb.

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Amyloid beta (ABeta) and tau protein are both implicated in memory impairment in early Alzheimer’s disease, but whether and how they interact to cause synaptic dysfunction are unknown. Consequently, I firstly investigated whether tau protein is required for the robust phenomenon of ABeta-induced impairment of hippocampal long-term potentiation (LTP), a widely accepted cellular model of memory. I demonstrate that the absence of tau prevents the ABeta-induced impairment of LTP; moreover, a specific inhibitor of the tau kinase glycogen synthase kinase 3 blocks both an ABeta-induced increase in ta
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Young, Richard N. (Richard Norman). "The effect of muscle contractility on surface EMG /." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=60423.

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This study was designed as an investigation of the role of changes in muscle force and changes in muscle length on the EMG for the Tibialis Anterior (TA).<br>Using surface electrodes we examined the EMG for 4 contraction levels at 5 ankle positions over 60$ sp circ$ of ankle rotation. The change in median frequency with muscle length identified a significant shift in the power spectrum to lower frequencies with increasing muscle length.<br>To further investigate our results we performed three other experiments: First, using X-rays to identify the relative change in distance between two intramu
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Zhang, Guangfan. "EFFECT OF CHRONIC AIRWAY INFLAMMATION INDUCED BY ALLERGEN SENSITIZATION ON VAGAL BRONCHOPULMONARY SENSORY NERVES IN RATS." UKnowledge, 2008. http://uknowledge.uky.edu/gradschool_diss/688.

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Airway hyperresponsivness (AHR) is one of most prominent pathophysiological features of asthma. Increasing evidence suggests that vagal bronchopulmonary afferents may be involved in the development of AHR. However, the underlying mechanisms are not clear. Therefore, the purpose of this dissertation was to investigate the effect of chronic airway inflammation induced by allergen sensitization on vagal bronchopulmonary afferents. The study was carried out in an animal model of allergic asthma. Brown-Norway rats were sensitized by intraperitoneal Ovalbumin (Ova) and exposed to aerosolized Ova 3 t
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Ling, I.-Fang. "REGULATION OF LOW DENSITY LIPOPROTEIN RECEPTOR SPLICING EFFICIENCY." UKnowledge, 2009. http://uknowledge.uky.edu/gradschool_diss/794.

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Low density lipoprotein receptor (LDLR) is an apolipoprotein E (apoE) receptor and may play a role in Alzheimer’s disease (AD) development. A single nucleotide polymorphism (SNP), rs688, that has been identified to modulate the splicing efficiency of LDLR exon 12 and is associated with higher cholesterol and AD in some case-control populations. The exon 12 deleted mRNA is predicted to produce a soluble form of LDLR that fails to mediate apoE uptake. To gain additional insights, in this study, I seek to understand the regulation of LDLR splicing efficiency. To identify functional cis-elements w
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42

Begg, Michael John. "The effect of hyperosmolarity on fluid-phase and receptor-mediated endocytosis in P388D1 macrophages." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/27137.

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Extracellular components can be internalized by either receptor-mediated or fluid-phase endocytosis. Receptor-mediated endocytosis involves the internalization of receptor-ligand complexes into coated vesicles of about 0.1 μm in diameter. The average diameter of primary pinocytic vesicles has been calculated to be 0.24 - 0.28 μm. The discrepancy in size between coated vesicles and the average pinosome diameter can be explained if, in addition to coated vesicles, another endocytic process involving vesicles larger than 0.28 μm in diameter takes place. These two vesicle types could together prod
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43

Cameron, Krasnodara. "Conduction states of the human dopamine transporter." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3676.

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Dysregulation of dopaminergic homeostasis has been established as the primary source of numerous neurological disorders including Parkinson’s and drug addiction. A tonic increase of dopamine (DA) in the nucleus accumbens is required for associating everyday events and behaviors with rewards. Yet many addictive exogenous compounds such as amphetamine (AMPH) and cocaine (COC) produce a much greater augmentation of synaptic DA levels that are linked to euphoria and a shift in behavior towards drug seeking. The protein responsible for maintaining extracellular levels of DA is the dopamine transpor
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44

Zalewski, Jacob T., Rowdy C. Jones, and Aaron J. Pd D. Polichnowski. "Severity of Acute Kidney Injury in Mice Associated with Ischemia Duration and Gender." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/29.

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Acute kidney injury (AKI) is a major health burden associated with a 50% mortality rate. Of particular concern, the incidence of AKI has increased dramatically over the last decade. Yet, there is a paucity of available treatments to prevent AKI or to reduce the high rate of AKI-associated mortality. A common cause of AKI, especially in hospital settings, is prolonged decreases in renal blood flow (i.e., renal ischemia). Recent studies have demonstrated that activating the cholinergic anti-inflammatory pathway via vagal stimulation can mitigate AKI severity in rodent models of renal ischemia-re
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45

Lumkwana, Dumisile. "Identifying appropriate attachment factors for isolated adult rat cardiomyocyte culture and experimentation." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86479.

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Thesis (MScMedSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Introduction: Primary culture of isolated adult rat cardiomyocytes (ARCMs) is an important model for cardiovascular research, but successful maintenance of these cells in culture for their use in experiments remains challenging (Xu et al, 2009; Louch et al, 2011). Most studies are done on acutely isolated cardiomyocytes immediately after isolation, which is due to low survival of these cells in culture. Obstacles in culture are due to the type of medium and attachment factors (tissue culture adhesives) used to culture and g
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46

Petousi, Nayia. "Functional variation in the hypoxia-inducible factor (HIF) pathway in humans." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:bf340955-5125-422e-befb-b2a7d55a1d39.

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By undertaking a number of different experimental approaches at the genetic, cellular/ molecular and integrative physiology levels, I investigated functional variation in the Hypoxia-Inducible Factor (HIF) transcription pathway in humans. My studies focused on Tibetan natives. Tibetan highlanders are adapted to life in a hypoxic environment and exhibit distinct physiological traits at high altitude. Recent studies identified positive selection at two genetic loci, EPAS1 (HIF2α) and EGLN1 (PHD2), in Tibetan highlanders and demonstrated an association of EGLN1/EPAS1 genotype with haemoglobin con
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Lampiao, Fanuel. "Effects of insulin and leptin on human spermatozoa function and their cross-talk with nitric oxide and cytokines." Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1083.

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Thesis (PhD (Biomedical Sciences. Medical Physiology))--University of Stellenbosch, 2009.<br>ENGLISH ABSTRACT: In recent years there has been an increase in obesity and diabetes mellitus (DM). These conditions have for a long time been associated with infertility. Obesity is characterized by high levels of circulating leptin and cytokines as well as insulin resistance. Type I DM is associated with low or no insulin whereas, Type II DM is characterised by insulin resistance. As the prevalence of obesity and DM continues to rise, it is likely that the incidence of infertility associated wit
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Salie, Ruduwaan. "The mechanism of pharmacological preconditioning of rat myocardium with beta-adrenergic agonists." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6630.

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Thesis (PhD)--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: The Mechanism of -adrenergic preconditioning ( -PC) Ischaemic preconditioning (IPC), a potent endogenous protective intervention against myocardial ischaemia, is induced by exposure of the heart to repetitive short episodes of ischaemia and reperfusion. The protective effects of this phenomenon have been demonstrated to be mediated by release of autocoids such as adenosine, opioids and bradykinin. Release of endogenous catecholamines and activation of the beta-adrenergic receptors (b-AR) have also been shown to be invo
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Van, Der Linde Michelle. "Gender selection: separation techniques for X- and Y-chromosome bearing human spermatozoa." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85629.

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Thesis (MScMedSc)-- Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Preconceptual sex selection is an ethically justifiable process whereby X- and Y-chromosome bearing spermatozoa are isolated prior to fertilization of the oocyte in order to generate either a male or a female offspring. Although various separation techniques are available, none can guarantee 100% accuracy. There are various physiological differences between X- and Y-chromosome bearing spermatozoa which can be used to separate these two populations of sperm. For the purpose of this study, X- and Y-chromosome bearing sperma
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Van, Vuuren Derick. "The role of Protein Phosphatase 2A (PP2A) in myocardial ischaemia/reperfusion injury." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86397.

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Thesis (PhD)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Ischaemic heart disease is a major contributor to global morbidity and mortality rates. Manoeuvres such as ischaemic preconditioning confer cardioprotection against ischaemia/reperfusion (I/R) injury by activating several intracellular signalling pathways. These pathways have been defined solely in terms of the kinases involved, despite the realization in recent years that protein phosphatase activity also contributes significantly to the attributes of the propagated signal. Protein phosphatase 2A (PP2A) is a heteromultimer
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