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Relevant bibliographies by topics / Physiopathology / Dissertations / Theses

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Dissertations / Theses on the topic 'Physiopathology'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Zumerle, Sara. "Tissue-specific role of hepcidin in iron homeostasis and innate immunity." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T002.

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Le fer est un élément vital pour l’organisme, mais peut s’avérer toxique si présent en excès. L’hepcidine est le régulateur principal de l’homéostasie du fer dans l’organisme. Un défaut d’expression d’hepcidine est à l’origine de l’hémochromatose, une maladie génétique humaine caractérisée par une surcharge en fer ; inversement, une hypersécrétion d’hepcidine est la cause de différents types d’anémie. L’hepcidine est secrétée principalement par le foie, mais des découvertes récentes ont montré que de nombreux tissus de l’organisme sont capables de produire l’hormone. Au laboratoire nous avons

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2

Gu, Xiaomei Everett Eric T. "Physiopathology of osteoclast in bone." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,1870.

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Thesis (M.S.)--University of North Carolina at Chapel Hill, 2008.<br>Title from electronic title page (viewed Dec. 11, 2008). "... in partial fulfillment of the requirements for the degree of Master of Science in the Curriculum of Oral Biology." Discipline: Oral Biology; Department/School: Dentistry.

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3

GAMBASSI, SILVIA. "Novel insights into alkaptonuria physiopathology." Doctoral thesis, Università di Siena, 2016. http://hdl.handle.net/11365/1004463.

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Alkaptonuria (AKU) is an ultra-rare genetic disease resulting from a deficient activity of the enzyme homogentisate 1,2- dioxygenase (HGD), responsible for the catabolism of the aromatic amino acids Phenylalanine and Tyrosine. This condition leads to the accumulation of a toxic metabolite, HGA and of its product of oxidation BQA, whose polymerization generates melanin-like aggregates, with amyloidogenic properties, leading to the phenomenon of “Ochronosis”. The most affected structures by the deposition of these ochronotic aggregates are joints, which undergo severe arthropathy; therefore, art

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4

De, Marco Margot. "BAG3 role in cardiomyocytes physiopathology." Doctoral thesis, Universita degli studi di Salerno, 2013. http://hdl.handle.net/10556/896.

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2010 - 2011<br>The anti-apoptotic protein BAG3 is expressed at high levels in skeletal and cardiac muscle in vivo. Our group recently focused its interest on BAG3 role in myocardiocyte proliferation, survival and response to stressful stimuli. We found that BAG3 is upregulated during the differentiation of cardiomyoblasts. Our results prompted us to verify whether bag3 silencing could affect the differentiation state of cardiocytes and we found that bag3 silencing resulted in highly reducing the levels of myogenin. Furthermore, we analyzed BAG3 expression and localization following cell exposu

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5

Pénicaud, Sidonie. "Insights about age of language exposure and brain development : a voxel-based morphometry approach." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111591.

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Early language experience is thought to be essential to develop a high level of linguistic proficiency in adulthood. Impoverished language input during childhood has been found to lead to functional changes in the brain. In this study, we explored if delayed exposure to a first language modulates the neuroanatomical development of the brain. To do so, voxel-based morphometry (VBM) was carried out in a group of congenitally deaf individuals varying in the age of first exposure to American Sign Language (ASL). To explore a secondary question about the effect of auditory deprivation on structural

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6

MURESAN, XIMENA MARIA. "Role of Scavenger receptor B1 in cutaneous physiopathology." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2488039.

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Scavenger receptor B1 (SR-B1) è una proteina transmembrana, coinvolta nel trasporto inverso di colesterolo a livello tissutale e definita anche recettore per HDL. Diversi studi hanno dimostrato che SR-B1 è implicato anche in altri processi, come regolazione dei livelli intracellulari di vitamine, riconoscimento di batteri e cellule apoptotiche e internalizzazione di vescicole. Nonostante il recettore sia localizzato principalmente a livello del fegato e dei tessuti steroidogenici, esso è significativamente espresso anche in altri tessuti compresa la cute umana, in special modo nell’epidermide.

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7

Calara, Federico Ben. "The vascular response to oxidative and mechanical stress /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980924cala.

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8

Bileviciute-Ljungar, Indre. "Bilateral neurogenic mechanisms following acute unilateral inflammation /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3168-2/.

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9

Löfgren, Olle. "Contribution of the sensory nervous system in thermally induced inflammation : an experimental study in the rat /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-3288-3/.

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10

Oldner, Anders. "Splanchnic organ homeostasis in experimental endotoxin shock : with special reference to the endothelin and renin-angiotensin systems /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3574-2/.

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11

Ernberg, Malin. "Significance of serotonin for pain, allodynia, and hyperalgesia in the human masseter muscle /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3779-6/.

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12

Weinberg, Jan. "Studies on ventilatory function in chronic neuromuscular disorders /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3936-5/.

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13

Flyckt, Lena. "Schizophrenia as a systemic disorder : studies of peripheral and central biological functions /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4482-2/.

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14

Peyronnet, Julie. "Regulation of cardiorespiratory homeostasis in adult and developing rat by catecholamines : effects of hypoxia /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4549-7/.

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15

Valiquette, Luc François. "Association between self-reported childhood maltreatment and cortisol profiles in psychotic patients." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112314.

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Childhood maltreatment is extremely common in patients diagnosed with psychotic disorders. Moreover, it has been linked with impaired functioning of the Hypothalamic-Pituitary-Adrenal axis. Furthermore, abnormality of the HPA has been found in psychotic patients. Presence of childhood maltreatment could then explain why the HPA axis is dysfunctional in these subjects. Our objective was to clarify the role of childhood trauma in the cortisol profiles of psychotic patients. Thirty-one patients underwent assessments of childhood maltreatment. Diurnal cortisol and cortisol after a controlled psych

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16

Zgheib, Sara. "Altérations physiologiques et récupération à long terme dans un modéle murin de séparation associée à une restriction du temps d'accés à l'alimentation : un outil pour l'étude des conséquences de l'anorexie mentale." Thesis, Littoral, 2014. http://www.theses.fr/2014DUNK0428/document.

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L'anorexie mentale (AM) est un trouble du comportement alimentaire qui se caractérise par une recherche obsessionnelle de minceur, une forte réduction de la prise alimentaire et une distorsion de l'image de soi. Elle est associée à de multiples perturbations endocriniennes et métaboliques, et à une altération de la masse et de la microarchitecture osseuses. Les facteurs et les mécanismes qui interviennent dans cette maladie sont très mal connus ce qui limite les options thérapeutiques. Il est donc nécessaire de développer un modèle animal qui reproduise les perturbations physiologiques observé

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17

Grudemo, Hans. "Rhinostereometry and laser doppler flowmetry : simultaneous measurements of inflammation and steroid effects in normal and allergic human nasal mucosa /." Stockholm, 2000. http://diss.kib.ki.se/2000/20000310grud/.

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18

Filliol, Aveline. "Etude de l’hépatolyse induite par les cellules immunitaires dans des modèles murins d’hépatites : rôles des protéines RIPK1 et PARP1/2." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1B051/document.

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La mort des hépatocytes est un des éléments initiateurs de la progression des maladies hépatiques par l’induction de processus inflammatoires et de régénération. Ces événements, bénéfiques à court terme pour le rétablissement de l’homéostasie hépatique sont parfois dérégulés et peuvent conduire au développement de la fibrose, de la cirrhose, voire d’un carcinome hépatocellulaire. Ainsi, les voies conduisant à la mort des hépatocytes et leur blocage comme une potentielle approche thérapeutique sont aujourd’hui étudiées. Les cellules de l’immunité innée et acquise sont responsables de l’inductio

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19

Belarbi, Essia. "Etude de la physiopathologie des infections à alphavirus arthritogènes par une approche d’imagerie in vivo." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS073.

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Les alphavirus arthritogènes de la rivière Ross (RRV) et du chikungunya (CHIKV) sont des arbovirus à l’origine de maladies inflammatoires musculosquelettiques chez l'homme. Ils sont largement distribués dans le monde et provoquent périodiquement des épidémies explosives. Les principaux signes cliniques lors d’une infection par un alphavirus arthritogène sont les myalgies, polyarthrites et arthralgies intenses pouvant persister plusieurs mois après l'infection. Les mécanismes de développement de l’infection et des manifestations persistantes sont peu connus. Pour étudier la pathogenèse de l'inf

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20

Ragnarsson, Gudmundur. "Abdominal symptoms and anorectal function in outpatients with the irritable bowel syndrome (IBS) /." Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/med651s.pdf.

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21

Hehenberger, Karin M. "In vitro studies of the diabetic condition using cultured fibroblasts with focus on wound healing /." Stockholm, 1997. http://diss.kib.ki.se/1997/19971219hehe.

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22

Wikström, Jonsson Eva. "Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2897-5.

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23

Lundberg, Steffan. "Assessment of tubal infertility : with radionuclide-labelled particles and falloposcopy /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980918lund.

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24

López, Annika. "The pelvic floor and genital prolapse : a clinical, physiological and radiological study /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4083-5/.

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25

Ylitalo, Riitta. "Clinical studies of contact granuloma and posterior laryngitis with special regard to esophagopharyngeal reflux /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4420-2/.

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26

Radell, Peter J. "Studies of diaphragm fatigue and dysfunction /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4751-1/.

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27

López, Serrano Clara. "Role of lysophosphatidic acid receptors in spinal cord injury physiopathology." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/458682.

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La médula espinal, la cual constituye una parte vital para el sistema nervioso central (SNC), puede resultar dañada a pesar de estar muy bien protegida por la columna vertebral, dando lugar a importantes consecuencias. La lesión medular provoca una alteración de las redes neuronales que están involucradas en diversas funciones fisiológicas. De hecho, dado que los axones del SNC de mamíferos adultos no pueden regenerarse tras una lesión, y que las células dañadas no pueden ser reparadas, esta patología viene acompañada de una pérdida funcional irreversible para los pacientes afectados. La fisi

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28

Valli, Emanuele <1983&gt. "The role of MYCN-mediated transcriptional repression in neuronal physiopathology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4809/1/Valli_Emanuele_tesi.pdf.

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MYC is a transcription factor that can activate transcription of several targets by direct binding to their promoters at specific DNA sequences (E-box). Recent findings have also shown that it can exert its biological role by repressing transcription of other set of genes. C-MYC can mediate repression on its target genes through interaction with factors bound to promoter regions but not through direct recognition of typical E-Boxes. In this thesis, we investigated whether MYCN can also repress gene transcription and how this is mechanistically achieved. Moreover, expression of TRKA, P75NTR

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Valli, Emanuele <1983&gt. "The role of MYCN-mediated transcriptional repression in neuronal physiopathology." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amsdottorato.unibo.it/4809/.

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MYC is a transcription factor that can activate transcription of several targets by direct binding to their promoters at specific DNA sequences (E-box). Recent findings have also shown that it can exert its biological role by repressing transcription of other set of genes. C-MYC can mediate repression on its target genes through interaction with factors bound to promoter regions but not through direct recognition of typical E-Boxes. In this thesis, we investigated whether MYCN can also repress gene transcription and how this is mechanistically achieved. Moreover, expression of TRKA, P75NTR

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30

Jensen-Urstad, Kerstin. "Heart rate variability and vascular function in healthy subjects and in patients with insulin-dependent (Type 1) diabetes mellitus /." Stockholm, 1997. http://diss.kib.ki.se/1997/19970822jens.

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31

Calota, Andra. "Reliability of spasticity measurement based on tonic stretch reflex threshold." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111947.

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Studies suggest that deficits in central regulation of stretch reflex thresholds (SRT) underlie both spasticity and other disorders of motor control. We investigated intra- and inter-evaluator reliability to quantify spasticity based on tonic SRT (TSRT) and the relationship between TSRT and Modified Ashworth Scale (MAS, clinical assessment of resistance to stretch). Spasticity was evaluated in 20 subjects with chronic stroke-related spasticity in two different days, by three evaluators. Twenty different velocity-dependent dynamic SRT (angle where biceps brachii EMG signal increased for a given

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32

Roux, Christian. "Arthrose des membres inférieurs : aspects épidémiologiques, cliniques et fondamentaux." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4001/document.

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L’arthrose est une pathologie fréquente et responsable d’une morbidité majeure. En France, cette pathologie est devenue une priorité de santé publique et jusqu’à récemment il n’existait aucune donnée épidémiologique en population générale. Mon travail a permis d’apporter les premiers chiffres de prévalence en population générale et a constitué une étape préliminaire essentielle à la réalisation d’une étude de prévalence nationale et à la constitution d’une cohorte de cas prévalents d’arthrose symptomatique des membres inférieurs. Ces travaux m’ont amené à m’intéresser à l’apport diagnostique d

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33

Bouasse, Malik. "Mise en place d’un modèle cellulaire permettant l’exploration fonctionnelle du canal ionique NALCN : caractérisation du courant de fuite induit par le canal humain NALCN et de différents mutants rencontrés dans un contexte pathologique." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT026.

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L'activité électrique des neurones dépend de la l’expression et de l'activité des canaux ioniques, dont le canal de fuite de sodique récemment décrit, appelé NALCN. Dans les neurones, NALCN est un canal activé par un récepteur couplé aux protéines G qui conduit un courant de fuite de sodium résistant à la TTX et résistant à Cs + et contribue à la mise en place du potentiel de la membrane du repos. Chez l'homme, des mutations récessives et dominantes de NALCN ont récemment été décrites dans des troubles neurologiques complexes tels que la Dystrophie Neuroaxonale Infantile (syndrome INAD) et l'A

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34

Anaf, Vincent. "Contribution to the physiopathology, symptomatology and treatment of deep infiltrating endometriosis." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211116.

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L’endométriose est définie comme la présence de tissu endométrial et de stroma en dehors de la cavité utérine. Ses localisations les plus fréquentes sont le péritoine pelvien et les ovaires. L’endométriose infiltrante est classiquement décrite comme la présence de tissu endométriotique plus de cinq millimètres sous le péritoine pelvien ou la séreuse d’un organe. Histologiquement il s’agit d’une lésion endométriotique mais qui contrairement aux lésions ovariennes ou péritonéales contient significativement plus de muscle lisse et de fibrose et est davantage associée à la douleur. Les lésions inf

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35

Tokuno, Shinichi. "Adaptation to ischemia with special emphasis on nitric oxide /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-023-7/.

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36

Hedenberg-Magnusson, Britt. "Masseter muscle pain and its relation to pain mediators in fibromyalgia and local myalgia /." Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-038-5/.

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37

Martin, Claes. "Pain and sensory function in HIV-infection : with and without antiretroviral therapy /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4238-2/.

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38

Chen, Jen-Kai 1971. "Neural substrates of persistent post-concussive symptoms : functional and structural neuroimaging studies with concussed male athletes." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111893.

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Mild head injury or concussion accounts for as many as 90% of all traumatic brain injuries and can sometime result in long-lasting and disabling post-concussion symptoms (PCS), even in the absence of detectable structural damage to the brain by morphological imaging. To date, the nature of persistent PCS following mild head injury remains poorly understood as objective and scientifically valid diagnostic tools are practically absent. This, in turn, likely accounts for missed diagnoses, prevents accurate assessment of the severity of the injury and creates difficulties for achieving proper pati

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39

Roux, Christian. "Arthrose des membres inférieurs : aspects épidémiologiques, cliniques et fondamentaux." Electronic Thesis or Diss., Nice, 2014. http://theses.unice.fr/2014NICE4001.

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L’arthrose est une pathologie fréquente et responsable d’une morbidité majeure. En France, cette pathologie est devenue une priorité de santé publique et jusqu’à récemment il n’existait aucune donnée épidémiologique en population générale. Mon travail a permis d’apporter les premiers chiffres de prévalence en population générale et a constitué une étape préliminaire essentielle à la réalisation d’une étude de prévalence nationale et à la constitution d’une cohorte de cas prévalents d’arthrose symptomatique des membres inférieurs. Ces travaux m’ont amené à m’intéresser à l’apport diagnostique d

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40

Mengoni, Ilaria <1986&gt. "Microglial involvement in brain physiopathology: in vitro studies using rat primary cultures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6466/1/mengoni_ilaria_tesi.pdf.

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Microglial involvement in neurological disorders is well-established, being microglial activation not only associated with neurotoxic consequences, but also with neuroprotective effects. The studies presented here, based on microglia rat primary cell cultures and mainly on microglial conditioned medium (MCM), show insights into the mechanism of Superoxide dismutase 1 (SOD1) and Apolipoprotein E (ApoE) secretion by microglia as well as their neuroprotective effect towards primary cerebellar granule neurons (CGNs) exposed to the dopaminergic toxin 6-hydroxydopamine (6-OHDA). SOD1 and ApoE ar

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41

Mengoni, Ilaria <1986&gt. "Microglial involvement in brain physiopathology: in vitro studies using rat primary cultures." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6466/.

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Microglial involvement in neurological disorders is well-established, being microglial activation not only associated with neurotoxic consequences, but also with neuroprotective effects. The studies presented here, based on microglia rat primary cell cultures and mainly on microglial conditioned medium (MCM), show insights into the mechanism of Superoxide dismutase 1 (SOD1) and Apolipoprotein E (ApoE) secretion by microglia as well as their neuroprotective effect towards primary cerebellar granule neurons (CGNs) exposed to the dopaminergic toxin 6-hydroxydopamine (6-OHDA). SOD1 and ApoE ar

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42

GALASSO, LETIZIA. "ACTIGRAPHIC ASSESSMENT OF SLEEP-ACTIVITY CYCLE IN PHYSIOPATHOLOGY: EXPERIMENTAL AND METHODOLOGICAL STUDIES." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/607722.

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The principal objective of my research during my PhD has been the investigation of the rest-activity circadian rhythms in physiopathology, dealing with both experimental and methodological issues. On the experimental side, the focus of my research program was centered on the investigation of the rest-activity circadian rhythms in patients with binge eating disorders. On the methodological side, my activity was aimed at exploring the relationships between the actigraphy-based assessment of circadian rhythmicity and the questionnaire-based assessment of circadian typology. The thesis is organi

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43

Nesbitt, Catherine. "Variations in maternal lickinggrooming influences both dam and offspring's hypothalamic-pituitary-adrenal hormone profile." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111562.

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Pup directed maternal licking and grooming (LG) increases with corticosterone (CORT) supplimentation (Rees et al 2004). Increases in LG lead to an attenuation of the adult offspring's HPA response to stress (Liu et aI1997). Similarly, Neonatal increases in glucocorticoids lead, in adulthood, to the same attenuation of the HPA stress response (Catalani et aI1993). We hypothesize that dams exhibiting increased LG will have increased circulating CORT, and this increase will be reflected in their offspring. This thesis characterizes the HPA hormone profile adrenocorticotropic hormone (ACTH), CORT

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44

Gamboa, Teresa Paula Rocha Soeiro Tavares. "Repercussões crónicas nas vias aéreas da hiperóxia neonatal : modelo experimental." Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2007. http://hdl.handle.net/10362/5516.

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RESUMO: O objectivo deste trabalho foi avaliar se a exposição crónica neonatal à hiperóxia mo-derada induz alterações funcionais e estruturais persistentes nas vias aéreas. Desenvolveu-se um modelo animal, no rato, a partir do qual se retiraram implicações para a compreensão das repercussões crónicas da hiperóxia neonatal sobre as vias aéreas de displasia broncopulmonar (DBP), em duas fases distintas: imediatamente após a exposi-ção neonatal a 50%O2 (grupo 50%O2) e após três semanas de recuperação em ar ambiente (grupo 50%O2+Ar).Compararam-se os resultados da resposta do músculo liso de traque

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45

Oskarsson, Per. "Studies on glucagon secretion in patients with type 1 diabetes : clinical and experimental studies /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3835-0/.

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46

Boström, Carina. "Shoulder and upper extremity impairments, activity limitation and physiotherapeutic exercise in women with rheumatoid arthritis : a biopsychosocial approach /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4192-0/.

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47

Schmotzer, Hans. "Knee joint contact stresses : the influence of deformity and muscle activity." Doctoral thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/26674.

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Studies have shown that the alignment of the knee in the coronal plane has a significant effect on the joint contact stress. However, gait analysis demonstrated that factors other than alignment contributed significantly to the outcome of corrective surgery. It was therefore hypothesized that muscle contraction can alter the stress distribution within the knee joint and that overloading can occur in the absence of a deformity. Six normal knees were harvested from different donors. The exact orientation of all muscle groups was recorded and their tendinous insertions carefully preserved. Custom

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48

Fraser, R. K. "The hip in the midlumbar myelomeningocele patient." Master's thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/26257.

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49

Cambuli, Francesca Maria. "Study of Musashi1-Expressing cells and of Musashi1 function in mouse intestinal physiopathology." Thesis, Lyon, École normale supérieure, 2012. http://www.theses.fr/2012ENSL0794.

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L’épithélium intestinal est une monocouche de cellules qui tapisse la lumière intestinale, constitué d’un compartiment différencié, les villosités dans l’intestin grêle et les plateaux épithéliaux dans le colon, et d’un compartiment prolifératif, les cryptes de Lieberkühn. Ce tissue se renouvelle de façon rapide et continue tout au long de la vie de l’individu, grâce à la présence de cellules souches adultes dans le fond des cryptes. Ces cellules s’autorenouvellent et donnent naissance à des progéniteurs prolifératifs (capables d’engendrer les différents cytotypes épithéliaux) qui se différenc

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Huang, Yen-Lin. "Analyse des altérations oncogéniques associées aux lymphomes NK/T de type nasal." Thesis, Paris Est, 2009. http://www.theses.fr/2009PEST0052.

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Abstract:

Dans les pays occidentaux, les lymphomes T périphériques et NK représentent environ 10% des lymphomes non-Hodgkiniens. Le lymphome NK/T de type nasal est l'une des entités de présentation extra-ganglionnaire les plus fréquentes, en Asie, et en Amérique Centrale et du Sud. Il survient classiquement dans la sphère nasopharyngée avec une prédilection pour les adultes jeunes. Morphologiquement, la tumeur est souvent angiocentrique avec une invasion de la paroi des vaisseaux par les cellules tumorales d'aspect variable. Ces lymphomes ont le plus souvent une origine NK avec un phénotype CD3+ (cytopl

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