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Journal articles on the topic 'Phytoalexines Anti- Inflammatory'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Aher, Kalyani Nandkishor, Mansi Dinkar Aher, Parina Nitin Aher, Komal Kishanlal Ahir, and Shital J. Patil* Dr. "RESVERATROL: A VERSATILE NEUTRACEUTICAL COMPOUND." World Journal of Pharmaceutical Science and Research 4, no. 1 (2025): 206–19. https://doi.org/10.5281/zenodo.14785106.

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Meng, Tiantian, Dingfu Xiao, Arowolo Muhammed, Juying Deng, Liang Chen, and Jianhua He. "Anti-Inflammatory Action and Mechanisms of Resveratrol." Molecules 26, no. 1 (2021): 229. http://dx.doi.org/10.3390/molecules26010229.

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Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits anti-oxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined. Multiple experimental studies that illustrate regulatory mechanisms and the immunomodul

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Chen, Xiangxiu, Xu Song, Xinghong Zhao, et al. "Insights into the Anti-inflammatory and Antiviral Mechanisms of Resveratrol." Mediators of Inflammation 2022 (August 12, 2022): 1–11. http://dx.doi.org/10.1155/2022/7138756.

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Resveratrol is a naturally occurring stilbene phytoalexin phenolic compound, which has been extensively studied on its biological activity. It has been widely accepted that resveratrol possesses anti-inflammatory and antiviral activities. In this review, we summarize the anti-inflammatory dosages and mechanism and antiviral mechanism of resveratrol. Since viral infections are often accompanied by inflammation, we propose that the NF-κB signaling pathway is a key and common molecular mechanism of resveratrol to exert anti-inflammatory and antiviral effects. For future studies, we believe that r

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Kim, Ki-Young, and Hee Kang. "Sakuranetin Inhibits Inflammatory Enzyme, Cytokine, and Costimulatory Molecule Expression in Macrophages through Modulation of JNK, p38, and STAT1." Evidence-Based Complementary and Alternative Medicine 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/9824203.

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Sakuranetin is flavonoid phytoalexin that serves as a plant antibiotic and exists inPrunusand several other plant species. Recently, we identified the anti-inflammatory effect ofPrunus yedoensisand found that there were few studies on the potential anti-inflammatory activity of sakuranetin, one of the main constituents ofPrunus yedoensis. Here, we isolated peritoneal macrophages from thioglycollate-injected mice and examined whether sakuranetin affected the response of the macrophages in response to lipopolysaccharide (LPS) plus interferon- (IFN-)γor LPS only. Sakuranetin suppressed the synthe

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Sandu, Mariana, Lucian Mihail Bîrsă, and Lucian Gabriel Bahrin. "Flavonoids – Small Molecules, High Hopes." Acta Chemica Iasi 25, no. 1 (2017): 6–23. http://dx.doi.org/10.1515/achi-2017-0003.

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AbstractThis brief review takes a look at flavonoids, a wide class of polyphenols, which are regarded as plant secondary metabolites. Their roles in plants are diverse and little understood. They can act as growth hormone modulators, phytoalexins, they offer UV protection, contribute to pollen viability and can function as signaling molecules in establishing symbiotic relationships. Flavonoids were also found to have a range of beneficial effects for the human body. Their anticancer, antioxidant, anti-inflammatory and cardioprotective activity, as well as their antibacterial, antiviral and ant

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Kim, Hyo Jung, Ji-Sun Lim, Woo-Keun Kim, and Jong-Sang Kim. "Soyabean glyceollins: biological effects and relevance to human health." Proceedings of the Nutrition Society 71, no. 1 (2011): 166–74. http://dx.doi.org/10.1017/s0029665111003272.

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Glyceollins, one family of phytoalexins, are de novo synthesised from daidzein in the soyabean upon exposure to some types of fungus. The efficiency of glyceollin production appears to be influenced by soyabean variety, fungal species, and the degree of physical damage to the soyabean. The compounds have been shown to have strong antioxidant and anti-inflammatory activities, and to inhibit the proliferation and migration of human aortic smooth muscle cells, suggesting their potential to prevent atherosclerosis. It has also been reported that glyceollins have inhibited the growth of prostate an

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Perri, Maria Rosaria, Michele Pellegrino, Mariangela Marrelli, et al. "Identification of Pinosylvin in Pinus nigra subsp. laricio: A Naturally Occurring Stilbenoid Suppressing LPS-Induced Expression of Pro-Inflammatory Cytokines and Mediators and Inhibiting the JAK/STAT Signaling Pathway." Pharmaceuticals 16, no. 5 (2023): 718. http://dx.doi.org/10.3390/ph16050718.

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Stilbenoids, a group of phytoalexin polyphenols produced by plants as a defence mechanism in response to stress conditions, are known for their anti-inflammatory potential. Pinosylvin, a naturally occurring molecule traditionally found in pinus trees, was here identified in Pinus nigra subsp. laricio var. calabrica from Southern Italy through HPLC analysis. Both this molecule and its well-known analogue resveratrol, the most famous wine polyphenol, were compared for their in vitro potential anti-inflammatory activity. Pinosylvin significantly inhibited the release of pro-inflammatory cytokines

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Siedlecka-Kroplewska, Kamila, Zbigniew Kmiec, and Michal Aleksander Zmijewski. "The Interplay Between Autophagy and Apoptosis in the Mechanisms of Action of Stilbenes in Cancer Cells." Antioxidants 14, no. 3 (2025): 339. https://doi.org/10.3390/antiox14030339.

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Plant-based stilbenes are low-molecular-weight polyphenolic compounds that exhibit anti-oxidant, anti-microbial, anti-fungal, anti-inflammatory, anti-diabetic, cardioprotective, neuroprotective, and anti-cancer activities. They are phytoalexins produced in diverse plant species in response to stress, such as fungal and bacterial infections or excessive UV irradiation. Plant-derived dietary products containing stilbenes are common components of the human diet. Stilbenes appear to be promising chemopreventive and chemotherapeutic agents. Accumulating evidence indicates that stilbenes are able to

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Cucuz, Veljko, Jelena Cvejic, and Ljiljana Gojkovic-Bukarica. "Clinical trials of resveratrol efficacy and safety." Vojnosanitetski pregled, no. 00 (2021): 6. http://dx.doi.org/10.2298/vsp201126006c.

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Trans-resveratrol is a phytoalexin from the stilbene class, polyphenolic compound from non-flavonoid group. In vitro and animal studies have shown that trans-resveratrol may exert a wide range of potential beneficial effects to human health, which involves antioxidant, anti-inflammatory, cardioprotective, neuroprotective, anti-diabetic and anti-cancer activity. The objective of this paper was to summarize available data concerning the most important clinical trials focused on resveratrol biological effects. The results of clinical trials indicate that resveratrol has potential cardioprotective

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*Dr., H. Rama Subba Reddy, M. Vijaya Kumar Dr., M. Ramesh Dr., et al. "THE NUTRITIONAL BENEFITS OF GRAPES - A VERSATILE SUPER FOOD FOR HEALTH AND WELLNESS." World Journal of Pharmaceutical Science and Research 4, no. 3 (2025): 78–84. https://doi.org/10.5281/zenodo.15561345.

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Since ancient times, people have adopted fruit-based diet plans and other regimens to recuperate from various medical conditions. Because grape (Vitis vinifera L.) has antibacterial, antioxidant, and anti-inflammatory properties, it is utilized not only for nutritional purposes but also for certain therapies. Fruits that are not climacteric, grapes are produced on woody vines that are both deciduous and perennial. Polyphenols, which have a wide range of biological activity and health-promoting advantages, are found in large quantities in grapes. One phytoalexin antioxidant that is created when

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Wiciński, Michał, Maciej Socha, Maciej Walczak, et al. "Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions." Nutrients 10, no. 11 (2018): 1813. http://dx.doi.org/10.3390/nu10111813.

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Resveratrol (RV) is a natural non-flavonoid polyphenol and phytoalexin produced by a number of plants such as peanuts, grapes, red wine and berries. Numerous in vitro studies have shown promising results of resveratrol usage as antioxidant, antiplatelet or anti-inflammatory agent. Beneficial effects of resveratrol activity probably result from its ability to purify the body from ROS (reactive oxygen species), inhibition of COX (cyclooxygenase) and activation of many anti-inflammatory pathways. Administration of the polyphenol has a potential to slow down the development of CVD (cardiovascular

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Lee, Min-Kyeong, Heeyeon Ryu, Hyeon Hak Jeong, and Bonggi Lee. "Brassinin Abundant in Brassicaceae Suppresses Melanogenesis through Dual Mechanisms of Tyrosinase Inhibition." Foods 12, no. 1 (2022): 121. http://dx.doi.org/10.3390/foods12010121.

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Brassinin is a phytoalexin abundant in plants, especially in cabbage, and has been reported to act as an anti-cancer and anti-inflammatory agent. However, limited studies are available to elucidate the functionalities of brassinin. Here, we tested the effects of brassinin on melanogenesis using cell-free and cell-based biochemical analysis and docking simulation. Cell-free experiments exhibited that brassinin has antioxidant and anti-tyrosinase activities. When applied to B16F10 cells stimulated with a melanogenesis inducer α-MSH, brassinin pretreatment significantly reduced melanin accumulati

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Sharifi-Rad, Javad, Natália Cruz-Martins, Pía López-Jornet, et al. "Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms." Oxidative Medicine and Cellular Longevity 2021 (August 23, 2021): 1–19. http://dx.doi.org/10.1155/2021/6492346.

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Coumarins belong to the benzopyrone family commonly found in many medicinal plants. Natural coumarins demonstrated a wide spectrum of pharmacological activities, including anti-inflammatory, anticoagulant, anticancer, antibacterial, antimalarial, casein kinase-2 (CK2) inhibitory, antifungal, antiviral, Alzheimer’s disease inhibition, neuroprotective, anticonvulsant, phytoalexins, ulcerogenic, and antihypertensive. There are very few studies on the bioavailability of coumarins; therefore, further investigations are necessitated to study the bioavailability of different coumarins which already s

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Guo, Bingnan, Yigen Peng, Yuting Gu, et al. "Resveratrol pretreatment mitigates LPS-induced acute lung injury by regulating conventional dendritic cells’ maturation and function." Open Life Sciences 16, no. 1 (2021): 1064–81. http://dx.doi.org/10.1515/biol-2021-0110.

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Abstract Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a severe syndrome lacking efficient therapy and resulting in high morbidity and mortality. Although resveratrol (RES), a natural phytoalexin, has been reported to protect the ALI by suppressing the inflammatory response, the detailed mechanism of how RES affected the immune system is poorly studied. Pulmonary conventional dendritic cells (cDCs) are critically involved in the pathogenesis of inflammatory lung diseases including ALI. In this study, we aimed to investigate the protective role of RES via pulmonary cDCs

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Li, Jia Lei, Yuan Gang Zu, Xiu Hua Zhao, et al. "Preparation, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Bovine Serum Album Nanoparticles." Advanced Materials Research 345 (September 2011): 349–54. http://dx.doi.org/10.4028/www.scientific.net/amr.345.349.

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Resveratrol (RES) is a naturally occurring triphenolic phytoalexin compound exerting numerous beneficial effects in the organism. It has a wide range of biological activities in vitro as well as in vivo, such as anti-cancer, antioxidant, anti-inflammatory and beneficial cardiovascular effects. But, its low solubility in water led to its poor absorption in vivo and low bioavailability. Bovine serum album (BSA) nanoparticles have emerged as versatile desired carrier systems due to its ready availability, biodegradability, lack of toxicity and immunogenicity with fast development of nano technolo

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Xue, You-Qiu, Jin-Ming Di, Yun Luo, Ke-Jun Cheng, Xing Wei, and Zhi Shi. "Resveratrol Oligomers for the Prevention and Treatment of Cancers." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/765832.

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Resveratrol (3,4′,5-trihydroxystilbene) is a naturally derived phytoalexin stilbene isolated from grapes and other plants, playing an important role in human health and is well known for its extensive bioactivities, such as antioxidation, anti-inflammatory, anticancer. In addition to resveratrol, scientists also pay attention to resveratrol oligomers, derivatives of resveratrol, which are characterized by the polymerization of two to eight, or even more resveratrol units, and are the largest group of oligomeric stilbenes. Resveratrol oligomers have multiple beneficial properties, of which some

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Sreepriya M, Sreepriya M., Bhimnaik S. Bhimnaik S, Bhavyasai Bhavyasai, Rumana A. Rumana A, and Divya M. Divya M. "Antiproliferative Effects of Phytoestrogens Formononetin and Resveratrol Against Human Pulmonary Adenocarcinoma Cells A 549." Biosciences Biotechnology Research Asia 19, no. 2 (2022): 309–19. http://dx.doi.org/10.13005/bbra/2986.

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Phytoestrogens are phytoalexins, plant secondary metabolites produced in response to microbial attacks and other forms of external stress stimuli. These compounds are devoid of the steroidal structure of endogenous estrogens but could bind with estrogen receptors with great affinity as they have structural similarity with endogenous/synthetic estrogens. Phytoestrogens are reported to possess several health benefits including cardio protective, antidiabetic, antioxidant and anti osteoporotic properties. Phytoestrogens like genistein, daidzein, and equol have been reported to possess excellent a

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Bryl, Anna, Mariusz Falkowski, Katarzyna Zorena, and Małgorzata Mrugacz. "The Role of Resveratrol in Eye Diseases—A Review of the Literature." Nutrients 14, no. 14 (2022): 2974. http://dx.doi.org/10.3390/nu14142974.

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Resveratrol (3,5,4′-trans-trihydroxystilbene) is a polyphenolic phytoalexin belonging to the stilbene family. It is commonly found in grape skins and seeds, as well as other plant-based foods. Oxidative stress and inflammation play a key role in the initiation and progression of age-related eye disorders (glaucoma, cataracts, diabetic retinopathy, and macular degeneration) that lead to a progressive loss of vision and blindness. Even though the way resveratrol affects the human body and the course of many diseases is still the subject of ongoing scientific research, it has been shown that the

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Змеева (Zmeeva), Ольга (Ol'ga) Николаевна (Nikolaevna), Наталья (Natal'ja) Эдуардовна (Eduardovna) Коломиец (Kolomiets), Наталья (Natal'ja) Юрьевна (Yur'evna) Абрамец (Abramets), and Руслан (Ruslan) Анатольевич (Anatol'evich) Бондарчук (Bondarchuk). "LOTUS CORNICULATUS L. IS A PERSPECTIVE SPECIES OF THE GENUS LOTUS L." chemistry of plant raw material, no. 4 (May 15, 2017): 5–14. http://dx.doi.org/10.14258/jcprm.2017041779.

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These materials contain an overview of the most significant publications on the hare (Lotus corniculatus L.) – one of the species of the genus Lotus L., widespread in the territory of the Russian Federation, both in the wild and in culture. The prospect of Lotus corniculatus is confirmed by information about its extensive range of information about the use in the folk medicine of many countries, veterinary science, resistance to disease, the ability to grow and give high yields on different types of soils, high fodder value and melliferous value. Chemical composition of wild and cultivated of

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de la Lastra, C. Alarcón, and I. Villegas. "Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications." Biochemical Society Transactions 35, no. 5 (2007): 1156–60. http://dx.doi.org/10.1042/bst0351156.

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Resveratrol (3,4′,5-trihydroxystilbene) is found in various plants, including grapes, berries and peanuts. It is also present in wines, especially red wines. During the last years, it has been the focus of numerous in vitro and in vivo studies investigating its biological attributes, which include mainly antioxidant and anti-inflammatory activities, anti-platelet aggregation effect, anti-atherogenic property, oestrogen-like growth-promoting effect, growth-inhibiting activity, immunomodulation and chemoprevention. In fact, recently, it has been demonstrated that the stilbene blocks the multiste

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Gugleva, Viliana, Stanimira Zasheva, Maya Hristova, and Velichka Andonova. "Topical use of resveratrol: technological aspects." Pharmacia 67, no. 2 (2020): 89–94. http://dx.doi.org/10.3897/pharmacia.67.e48472.

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Resveratrol is a natural polyphenolic phytoalexin found in grapes, berry skins, roots of Japanese knotweed and is reputed as an excellent antioxidant, anti-inflammatory, neuro- and cardio- protective agent. Resveratrol has also beneficial effects in therapy of different skin conditions such as acne, exfoliative eczema, psoriasis and is known to provide a protection against ultraviolet radiation-mediated oxidative stress. However, its low oral bioavailability and short biological half- life compromise its beneficial therapeutic effects; therefore, its topical application is a practical approach

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Gugleva, Viliana, Stanimira Zasheva, Maya Hristova, and Velichka Andonova. "Topical use of resveratrol: technological aspects." Pharmacia 67, no. (2) (2020): 89–94. https://doi.org/10.3897/pharmacia.67.e48472.

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Resveratrol is a natural polyphenolic phytoalexin found in grapes, berry skins, roots of Japanese knotweed and is reputed as an excellent antioxidant, anti-inflammatory, neuro- and cardio- protective agent. Resveratrol has also beneficial effects in therapy of different skin conditions such as acne, exfoliative eczema, psoriasis and is known to provide a protection against ultraviolet radiation-mediated oxidative stress. However, its low oral bioavailability and short biological half- life compromise its beneficial therapeutic effects; therefore, its topical application is a practical approach

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Trombino, Sonia, Roberta Cassano, Maria Luisa Di Gioia, and Francesca Aiello. "Emerging Trends in Green Extraction Techniques, Chemical Modifications, and Drug Delivery Systems for Resveratrol." Antioxidants 14, no. 6 (2025): 654. https://doi.org/10.3390/antiox14060654.

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Resveratrol is a naturally occurring phytoalexin found in red grapes, cocoa berries, and red grape wine. This compound exhibits potent antioxidant, anti-inflammatory, and anticancer properties. However, its clinical application is significantly hindered by poor aqueous solubility and rapid degradation at physiological pH, resulting in extremely low systemic bioavailability. This review explores three key aspects: green extraction methods for the efficient and sustainable isolation of resveratrol; structure–activity relationship studies of resveratrol derivatives to identify compounds with impr

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Wang, Won-Bo, Hsin-Chih Lai, Po-Ren Hsueh, Robin Y. Y. Chiou, Shwu-Bin Lin, and Shwu-Jen Liaw. "Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol." Journal of Medical Microbiology 55, no. 10 (2006): 1313–21. http://dx.doi.org/10.1099/jmm.0.46661-0.

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Resveratrol (3,5,4-trihydroxy-trans-stilbene) is a phytoalexin compound with anti-inflammatory and antioxidant activities. The effect of resveratrol on swarming and virulence factor expression of Proteus mirabilis, an important pathogen infecting the urinary tract, was determined on swarming agar plates with and without the compound. Bacteria harvested at different times were assayed for cell length and the production of flagella, haemolysin and urease. Resveratrol inhibited P. mirabilis swarming and virulence factor expression in a dose-dependent manner. Resveratrol significantly inhibited sw

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Molnar, Richard, Laszlo Szabo, Andras Tomesz, et al. "The Chemopreventive Effects of Polyphenols and Coffee, Based upon a DMBA Mouse Model with microRNA and mTOR Gene Expression Biomarkers." Cells 11, no. 8 (2022): 1300. http://dx.doi.org/10.3390/cells11081300.

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Polyphenols are capable of decreasing cancer risk. We examined the chemopreventive effects of a green tea (Camellia sinensis) extract, polyphenol extract (a mixture of blackberry (Rubus fruticosus), blackcurrants (Ribes nigrum), and added resveratrol phytoalexin), Chinese bayberry (Myrica rubra) extract, and a coffee (Coffea arabica) extract on 7,12-dimethylbenz[a]anthracene (DMBA) carcinogen-increased miR-134, miR-132, miR-124-1, miR-9-3, and mTOR gene expressions in the liver, spleen, and kidneys of CBA/Ca mice. The elevation was quenched significantly in the organs, except for miR-132 in th

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Kim, Hyo Jung, Byung-Yoon Cha, Bongkeun Choi, Ji Sun Lim, Je-Tae Woo, and Jong-Sang Kim. "Glyceollins inhibit platelet-derived growth factor-mediated human arterial smooth muscle cell proliferation and migration." British Journal of Nutrition 107, no. 1 (2011): 24–35. http://dx.doi.org/10.1017/s0007114511002571.

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Platelet-derived growth factor (PDGF)-BB can induce abnormal proliferation and migration of vascular smooth muscle cells (VSMC) that are involved in the development of CVD. In our preliminary study, phytoalexin glyceollins (glyceollins I, II and III) isolated from soyabean seeds cultured withAspergillus sojaeshowed strong antioxidant and anti-inflammatory activity. Since antioxidants showed beneficial effects on chronic inflammatory diseases, the purpose of the present study was to examine the effects of glyceollins on PDGF-induced proliferation and migration in human aortic smooth muscle cell

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Salehi, Bahare, Abhay Mishra, Manisha Nigam, et al. "Resveratrol: A Double-Edged Sword in Health Benefits." Biomedicines 6, no. 3 (2018): 91. http://dx.doi.org/10.3390/biomedicines6030091.

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Resveratrol (3,5,4′-trihydroxy-trans-stilbene) belongs to polyphenols’ stilbenoids group, possessing two phenol rings linked to each other by an ethylene bridge. This natural polyphenol has been detected in more than 70 plant species, especially in grapes’ skin and seeds, and was found in discrete amounts in red wines and various human foods. It is a phytoalexin that acts against pathogens, including bacteria and fungi. As a natural food ingredient, numerous studies have demonstrated that resveratrol possesses a very high antioxidant potential. Resveratrol also exhibit antitumor activity, and

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Likhitwitayawuid, Kittisak. "Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems." Molecules 26, no. 14 (2021): 4212. http://dx.doi.org/10.3390/molecules26144212.

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Oxyresveratrol has recently attracted much research attention due to its simple chemical structure and diverse therapeutic potentials. Previous reviews describe the chemistry and biological activities of this phytoalexin, but additional coverage and greater accessibility are still needed. The current review provides a more comprehensive summary, covering research from 1955 to the present year. Oxyresveratrol occurs in both gymnosperms and angiosperms. However, it has never been reported in plants in the subclass Sympetalae, and this point might be of both chemotaxonomic and biosynthetic import

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Takizawa, Yoshie, Yukiko Kosuge, Hiroyo Awaji, et al. "Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells." British Journal of Nutrition 110, no. 12 (2013): 2150–55. http://dx.doi.org/10.1017/s0007114513001670.

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Resveratrol, a polyphenolic phytoalexin found in red wine and various plants, has been reported to up-regulate the expression of endothelial NO synthase (eNOS) in human umbilical vein endothelial cells (HUVEC). However, this effect was neither long term in nature nor physiologically relevant at the concentration of resveratrol studied. In the present study, we investigated the effects of repeated treatments with a lower concentration of resveratrol on the expression of genes in HUVEC. The expression levels of eNOS and silent mating type information regulation 2 homologue 1 (SIRT1) were up-regu

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Venkatesan, Balachandar, Anthony J. Valente, Venkatapuram Seenu Reddy, Deborah A. Siwik, and Bysani Chandrasekar. "Resveratrol blocks interleukin-18-EMMPRIN cross-regulation and smooth muscle cell migration." American Journal of Physiology-Heart and Circulatory Physiology 297, no. 2 (2009): H874—H886. http://dx.doi.org/10.1152/ajpheart.00311.2009.

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Vascular smooth muscle cell (SMC) migration is an important mechanism in atherogenesis and postangioplasty arterial remodeling. Previously, we demonstrated that the proinflammatory cytokine interleukin (IL)-18 is a potent inducer of SMC migration. Since extracellular matrix metalloproteinase inducer (EMMPRIN) stimulates ECM degradation and facilitates cell migration, we investigated whether IL-18 and EMMPRIN regulate each other's expression, whether their cross talk induces SMC migration, and whether the phytoalexin resveratrol inhibits IL-18-EMMPRIN signaling and SMC migration. Our studies de

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Alghetaa, Hasan F., Amira K. Mohammed, Prakash Nagarkatti, and Mitzi Nagarkatti. "Attenuation of Staphylococcal enterotoxin-B (SEB)-induced lung injury (ALI) by resveratrol results from miR-193a down-regulation and alterations in metabolic profile." Journal of Immunology 198, no. 1_Supplement (2017): 67.21. http://dx.doi.org/10.4049/jimmunol.198.supp.67.21.

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Abstract Resveratrol, (RES), a phytoalexin, is well-known for its anti-inflammatory and anti-oxidant properties. SEB, a superantigen, is known to trigger ALI and cause mortality. In the current study, we tested the effect of RES in a dual-dose model of SEB exposure that triggers ALI and causes 100% mortality in C3H/HeJ-mice. The data revealed RES attenuated SEB-induced ALI and prevented mortality. Forty eight hours post-SEB exposure, lung-infiltrating mononuclear cells were tested for microRNA expression profile to determine the epigenetic regulation by resveratrol. SEB-activated splenocytes w

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Moore, Alyssa, Joshua Beidler, and Mee Hong. "Resveratrol and Depression in Animal Models: A Systematic Review of the Biological Mechanisms." Molecules 23, no. 9 (2018): 2197. http://dx.doi.org/10.3390/molecules23092197.

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Depression is currently treated by pharmacotherapies that can elicit debilitating side effects for patients. Novel treatment options with limited side effects are currently being researched. Resveratrol is a polyphenol and phytoalexin found in the skins of grapes, red wine, Japanese knotweed, and peanuts. It has been studied extensively for its antioxidant and anti-inflammatory properties. Resveratrol has also gained attention for its neuroprotective properties. The aim of the review was to examine the mechanisms by which resveratrol reduces depressive behaviors in animal models. In total, 22

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Glehr, Mathias, Margherita Breisach, Sonja Walzer та ін. "ILThe Infl uence of Resveratrol on the Synovial Expression of Matrix Metalloproteinases and Receptor Activator of NF-κB Ligand in Rheumatoid Arthritis Fibroblast-Like Synoviocytes". Zeitschrift für Naturforschung C 68, № 7-8 (2013): 336–42. http://dx.doi.org/10.1515/znc-2013-7-812.

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Medication of rheumatoid arthritis (RA) remains challenging and often controversial concerning side effects or long-term complications. We investigated the effect of resveratrol, a phytoalexin discussed for its chondro-protective and anti-inflammatory qualities, on the synovial expression of matrix-degrading enzymes like matrix metalloproteinases (MMPs) and bone-remodelling proteins in RA fibroblast-like synoviocytes (FLS). Interleukin-1β- stimulated RA-FLS were treated with 100 μM resveratrol for 24 h. To evaluate the effect of resveratrol on the amount of bound/combined MMPs, a Luminex® xMAP

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Li, Chunxue, Rongrong Zhang, Yating Zhan, and Jianjian Zheng. "Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway." Mediators of Inflammation 2021 (October 13, 2021): 1–14. http://dx.doi.org/10.1155/2021/3399357.

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Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). Resveratrol (Res), a polyphenol phytoalexin, has been demonstrated to show anti-inflammatory, antioxidative, antiproliferative, and chemopreventive activities. In recent years, Res has been found to inhibit liver fibrosis. Enhanced Hippo pathway activation has also been reported to inhibit tumor progression and liver fibrosis. In the present study, the role of the Hippo pathwa

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Valenzuela, Hector, Brenda Molgora, Riley Bateman, Jennifer Wu, Greg Sweeney, and Rita Effros. "Resveratrol and curcumin: effects on human T cells (50.7)." Journal of Immunology 186, no. 1_Supplement (2011): 50.7. http://dx.doi.org/10.4049/jimmunol.186.supp.50.7.

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Abstract Various natural products have been proposed to both increase health at the organismic level, and delay the onset of cellular aging. Of particular interest is resveratrol, a phytoalexin that has been demonstrated to have cardioprotective effects and to slow the progression of a variety of illnesses, including various types of cancers. More recently, resveratrol has been demonstrated to increase the maximum lifespan of model organisms, such as C. elegans, D. melanogaster and N. furzeri. However, the potential health benefits of resveratrol and other similar compounds on the human immune

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Vitalini, Sara, Serhat S. Cicek, Sebastian Granica, and Christian Zidorn. "Dihydroresveratrol Type Dihydrostilbenoids: Chemical Diversity, Chemosystematics, and Bioactivity." Current Medicinal Chemistry 25, no. 10 (2018): 1194–240. http://dx.doi.org/10.2174/0929867324666170830112343.

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Background: Dihydrostilbenoids, a diverse class of natural products differing from stilbenoids by the missing double bond in the ethylene chain linking the aromatic moieties, have been reported from fungi, mosses, ferns, and flowering plants. Objective: Occurrence, structure, and bioactivity of naturally occurring dihydroresveratrol type dihydrostilbenoids are discussed in this review. Method: A Reaxys database search for dihydroresveratrol derivatives with possible substitutions on all atoms, but excluding non-natural products and compounds featuring additional rings involving the ethyl conne

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Cruz, Mycheli Preuss da, Sérgio Miguel Mazaro, Janaína Bruzamarello, et al. "Bioactive Compounds of Ganoderma lucidum Activate the Defense Mechanisms of Soybean Plants and Reduce the Severity of Powdery Mildew." Journal of Agricultural Science 11, no. 13 (2019): 99. http://dx.doi.org/10.5539/jas.v11n13p99.

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Ganoderma lucidum is a medicinal mushroom widely used in Eastern countries and currently in global scale. Its fruiting body and mycelium are composed by polysaccharides, triterpenes and more than 200 secondary metabolites. These compounds exhibit a range of bioactivities, such as anti-inflammatory, antitumorigenic, antibacterial and antifungal action. Several scientific publications have demonstrated the potential and performance of G. lucidum compounds in the control of diseases in animals and humans. However, there is a lack of information on the effect of their compounds on the phytopathoge

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Rahman, Md Ataur, Yoonjeong Cho, Ghilsoo Nam, and Hyewhon Rhim. "Antioxidant Compound, Oxyresveratrol, Inhibits APP Production through the AMPK/ULK1/mTOR-Mediated Autophagy Pathway in Mouse Cortical Astrocytes." Antioxidants 10, no. 3 (2021): 408. http://dx.doi.org/10.3390/antiox10030408.

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Oxyresveratrol (OxyR), a well-known polyphenolic phytoalexin, possesses a wide range of pharmacological and biological properties, comprising antioxidant, anti-inflammatory, free radical scavenging, anti-cancer, and neuroprotective activities. Autophagy is a cellular self-degradation system that removes aggregated or misfolded intracellular components via the autophagosome-lysosomal pathway. Astrocyte accumulation is one of the earliest neuropathological changes in Alzheimer’s disease (AD), and amyloid precursor protein (APP) is the hallmark of AD. OxyR could affect APP modulation via the auto

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Agin, Hatice Demircan, Nedim Gunes, and Ridvan Guler. "A comparative investigation of the effects of Resveratrol and dental pulp delivered mesenchimal stem cells on rat tibia bone defect healing." Revista Científica de la Facultad de Ciencias Veterinarias XXXIV, no. 2 (2024): 1–7. http://dx.doi.org/10.52973/rcfcv-e34372.

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Resveratrol (3,4,5–trihydroxystilbene), an antioxidant compound, has a natural phytoalexin structure and also has many properties such as anti–inflammatory, antineoplastic and antiplatelet. In addition, mesenchymal stem cells isolated from various tissues are considered as a potential cell source for bone regenerative therapies. The present study aims to examine the effects of Resveratrol and dental pulp–derived mesenchymal stem cells on new bone formation in rats, both isolated and combined, by immunohistochemical methods. Twenty eigth Spraque Dawley male rats were used in the study. The rats

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Lee, K., C. Wang, D. Miller, and Z. Machaty. "117 EFFECT OF RESVERATROL ON THE CULTURE OF PORCINE EMBRYOS." Reproduction, Fertility and Development 21, no. 1 (2009): 158. http://dx.doi.org/10.1071/rdv21n1ab117.

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Resveratrol (3,4′,5-trihydroxystilbene) is a phytoalexin present in a variety of dietary sources including grapes, plums and peanuts. It was shown to exert a wide variety of pharmacological activities ranging from anti-inflammatory effects to immunomodulation and chemoprevention. The aim of this study was to investigate the effect of resveratrol on porcine embryo development. In vitro-matured pig oocytes were activated by two direct current electric pulses (60 μ seconds each) followed by an incubation with 10 μg mL–1 cycloheximide and 7.5 μg mL–1 cytochalasin B, for 5 h. Activated oocytes (in

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Sun, Xiaodong, Shenglan Feng, Bingqing Qin та ін. "Integrated multi-omics profiling highlights the benefits of resveratrol hydroxypropyl-β-cyclodextrin inclusion complex for A53T transgenic mice through microbiota-gut-brain axis". Food & Function, 2023. http://dx.doi.org/10.1039/d3fo03667g.

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Parkinson's disease (PD) is a neurological disorder characterized by motor and gastrointestinal dysfunctions. Resveratrol is a potent antioxidant and anti-inflammatory phytoalexin known for its health-promoting benefits. However, little is known...

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Tambe, Vrushali, Rohini Pujari, Archana Karnik, and Prerana Dongre. "Pterostilbene: A Review on its Pharmacological Activities." Research Journal of Pharmacy and Technology, November 30, 2023, 5514–21. http://dx.doi.org/10.52711/0974-360x.2023.00892.

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Pterostilbene is a type of stilbenoids, a phenolic compound found in various plant species. It is an antimicrobial phytoalexins produced in plants to protect against fungal infection and toxins. In this review, the biological effects of pterostilbene are discussed. It is reported to have wide array of actions including anticancer, neuroprotective, antidiabetic, antiobesity, antihyperlipidemic, anti-atherosclerotic, cardioprotective, antihypertensive, anti-inflammatory, anti-arthritic, antioxidant, anti-allergic, anti-anxiety, anti-androgenic and antifungal activity. Its anticancer potential is

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Oh, Won Young, Yue Gao, and Fereidoon Shahidi. "Stilbenoids: chemistry, occurrence, bioavailability and health effects—a review." Journal of Food Bioactives 13 (March 31, 2021). http://dx.doi.org/10.31665/jfb.2020.13256.

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Stilbenoids are synthesized by plants in response to external stimuli such as infection and UV-irradiation, thus known as phytoalexins. Stilbenoids include resveratrol, piceid, piceatannol, pterostilbene, astringin, and viniferin and have been of interest due to their myriad of health benefits, such as antioxidant, anti-inflammatory, anticancer, and anti-diabetic effects. Despite their numerous health effects, the bioavailability of stilbenoids is poor. However, the existing literature on this subject is fragmented and thus collective effort is needed to better understand their role before and

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Kohandel, Zeynab, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, and Saeed Samarghandian. "STAT3 pathway as a molecular target for resveratrol in breast cancer treatment." Cancer Cell International 21, no. 1 (2021). http://dx.doi.org/10.1186/s12935-021-02179-1.

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AbstractSignal transducer and activator of transcription 3 (STAT3) induces breast cancer malignancy. Recent clinical and preclinical studies have demonstrated an association between overexpressed and activated STAT3 and breast cancer progression, proliferation, metastasis, and chemoresistance. Resveratrol (RES), a naturally occurring phytoalexin, has demonstrated anti-cancer activity in several disease models. Furthermore, RES has also been shown to regulate the STAT3 signaling cascade via its anti-oxidant and anti-inflammatory effects. In the present review, we describe the STAT3 cascade sign

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Junaid, Md, Bristy Basak, Yeasmin Akter, et al. "Sakuranetin and its therapeutic potentials – a comprehensive review." Zeitschrift für Naturforschung C, July 13, 2022. http://dx.doi.org/10.1515/znc-2022-0024.

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Abstract Sakuranetin (SKN), a naturally derived 7-O-methylated flavonoid, was first identified in the bark of the cherry tree (Prunus spp.) as an aglycone of sakuranin and then purified from the bark of Prunus puddum. It was later reported in many other plants including Artemisia campestris, Boesenbergia pandurata, Baccharis spp., Betula spp., Juglans spp., and Rhus spp. In plants, it functions as a phytoalexin synthesized from its precursor naringenin and is the only known phenolic phytoalexin in rice, which is released in response to different abiotic and biotic stresses such as UV-irradiati

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Alaasam, Elaf R., Ali M. Janabi, Karrar M. Al-Buthabhak, et al. "Nephroprotective role of resveratrol in renal ischemia-reperfusion injury: a preclinical study in Sprague-Dawley rats." BMC Pharmacology and Toxicology 25, no. 1 (2024). http://dx.doi.org/10.1186/s40360-024-00809-8.

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Abstract Background Renal ischemia-reperfusion injury (IRI) is a significant contributor to renal dysfunction, acute kidney injury (AKI), and associated morbidity and mortality. Resveratrol, a polyphenol and phytoalexin, is known for its anti-inflammatory, antioxidant, and anti-cancer properties. This study investigates the nephroprotective potential of resveratrol in a rat model of renal IRI. Materials and methods Twenty-eight male Sprague-Dawley rats were divided into four groups: Sham, IRI, DMSO, and Resveratrol. The Sham group underwent identical procedures without renal pedicle clamping,

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Neves, Ana Rute, Ana Joyce Coutinho, Marina Pinheiro, and Madalena M. M. Pinto. "Therapeutic potential of genistein: preclinical studies, clinical evidence, and nanotechnology application." Current Medicinal Chemistry 29 (October 4, 2022). http://dx.doi.org/10.2174/0929867329666221004124800.

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Abstract: Genistein (4’,5,7-trihydroxyisoflavone) is a natural plant-derived phytoestrogen that can be found, for example, in soybean seeds. Genistein is present mainly in the human diet and is a common precursor in the antimicrobial phytoalexins biosynthesis and phytoanticipins in vegetables. The interest in genistein has increased due to its pharmacological effects, including anti-cancer activity, neuroprotective effects, cardiovascular protection, anti-inflammatory effects, antioxidant activity, and prevention of obesity. The most challenging issue for improving genistein is its low oral bi

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Christofori, M. R. R. Nastiti, Dwiastuti Rini, and D. O. Riswanto Florentinus. "Response Surface Methodology Assisted Surfactant Optimization on the Novel Resveratrol Self-assembly Nanoemulsions." Research Journal of Pharmacy and Technology, January 27, 2023, 411–17. http://dx.doi.org/10.52711/0974-360x.2023.00070.

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Resveratrol, a strong antioxidant and anti-inflammatory phytoalexin is potential to relieve impaired diabetic wound healing. Self-assembly nanoemulsions were developed to formulate good quality of resveratrol topical preparation. The surfactant system consisted of Kolliphor® RH 40 and Transcutol® were further optimized in terms of viscosity, pH and the percentage of transmittance. A central composite design combined with the response surface methodology successfully resulted in surface responses with the desirability value for viscosity, pH, and transmittance percentage were 0.99742, 0.60598,

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Seo, HyeLin, GwangRae Jo, YaeJin Woo, et al. "Glyceollins Attenuates AOM/DSS‐induced Colorectal Cancer Development in C57BL/6 Mice." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.1167.15.

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Glyceollins are soybean phytoalexin possessing anti‐inflammatory and anti‐carcinogenic activities. In this study, we examined if glyceollin administration suppresses cancer development using an inflammatory colorectal cancer animal model, azoxymethane/dextran sodium sulfate (AOM/DSS)‐treated C57BL/6 mice. To enrich glyceollins, soybean seeds were inoculated with Aspergillus sojae. After 7 day‐incubation, the soybeans were extracted in 80% ethanol. Glyceollins were subsequently purified by liquid chromatography from the extract. The prepared glyceollins were orally administered to AOM/DSS‐treat

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Kaur, Arshpreet, Ruchi Tiwari, Gaurav Tiwari, and Vadivelan Ramachandran. "Resveratrol: A Vital Therapeutic Agent with Multiple Health Benefits." Drug Research, August 19, 2021. http://dx.doi.org/10.1055/a-1555-2919.

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AbstractResveratrol (RSV), the most effective stilbene phytoalexin synthesized naturally or induced in plants as part of their defense mechanism, is a key component of natural phenolic compounds and is being considered as a treatment option for a variety of diseases. RSV was discovered in the skin of red grapes, mulberries, peanuts, pines, and Polygonum cuspidatum weed root extracts. It was first extracted from white hellebore (Veratrum grandiflorum O. Loes) roots in 1940, then from Polygonum cuspidatum roots in 1963. However, RSV’s use as a drug is limited due to its initial conformational st

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