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Journal articles on the topic 'PHYTOCHEMICAL CANDIDATES'

Author: Grafiati

Published: 9 November 2023

Last updated: 31 July 2025

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1

Grădinaru, Teodora-Cristiana, Marilena Gilca, Adelina Vlad, and Dorin Dragoș. "Relevance of Phytochemical Taste for Anti-Cancer Activity: A Statistical Inquiry." International Journal of Molecular Sciences 24, no. 22 (2023): 16227. http://dx.doi.org/10.3390/ijms242216227.

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Targeting inflammation and the pathways linking inflammation with cancer is an innovative therapeutic strategy. Tastants are potential candidates for this approach, since taste receptors display various biological functions, including anti-inflammatory activity (AIA). The present study aims to explore the power different tastes have to predict a phytochemical’s anti-cancer properties. It also investigates whether anti-inflammatory phytocompounds also have anti-cancer effects, and whether there are tastes that can better predict a phytochemical’s bivalent biological activity. Data from the Plan

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Eskundari, Ratna Dewi, Tri Wiharti, Nur Rokhimah Hanik, Fety Fatimah, Umi Salamah, and Antik Murwani. "Phytochemical test of several eco-handsanitizer candidates." Jurnal Biologi Tropis 22, no. 1 (2022): 297–303. http://dx.doi.org/10.29303/jbt.v22i1.3258.

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Ecoenzymes are natural ingredients formed from the fermentation of fruit and or vegetable residues that have many benefits. One of the benefits of ecoenzymes is that they can be used as eco-handsanitizers; which can be used as a candidate for handsanitizer for those who are allergic to alcohol-based handsanitizer. This study aims to determine the pH, antibacterial, antiviral, and antifungal content of the candidate eco-handsanitizer solution through alkaloid, flavonoid, and saponin test, also fungal-inhibition test. The candidate eco-handsanitizer solution was made from an ecoenzyme solution d

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Sadiq, Shifana C., Maria Pellissery Joy, Sreekumar U. Aiswarya, et al. "Unlocking nature’s pharmacy: an in-depth exploration of phytochemicals as potential sources of anti-cancer and anti-inflammatory molecules." Exploration of Drug Science 2, no. 6 (2024): 744–84. http://dx.doi.org/10.37349/eds.2024.00073.

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Phytochemicals, the bioactive compounds derived from plants, play a significant role in modulating pathways leading to cancer and inflammation, rendering themselves promising candidates for therapeutic interventions. This review explores the multifaceted potential of various phytochemicals in modulating key mechanisms involved in the development and progression of cancer and inflammation. The diverse array of phytochemicals discussed here encompasses polyphenols, flavonoids, alkaloids, terpenoids, and many others, each with distinct molecular targets and modes of action. This review is an atte

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JR, Naidu. "Phytochemical and Chemical Characterization of Centella Asiatica and Cymbopogan Citratus Extracts." Bioequivalence & Bioavailability International Journal 7, no. 2 (2023): 1–17. http://dx.doi.org/10.23880/beba-16000213.

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Epidemiological studies have consistently linked abundant consumption of foods of plant origin, to the reduced risk of cancer. The present study was conducted to perform the of chemical and phytochemical characterization of selected medicinal herbs Centella asiatica and Cymbopogan citratus which are commonly used in Malaysian diet. Phytochemical and chemical characterization of the plant extracts were determined by qualitative phytochemical analysis, HPLC analysis and GC-TOFMS analysis. The results from the phytochemical analysis indicated the presence of saponin, anthroquinone, flavonoid, tan

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Gu, Shaobin, Ying Wu, and Jianbo Yang. "Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals." PeerJ 4 (May 11, 2016): e1983. http://dx.doi.org/10.7717/peerj.1983.

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As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a micronucleus assay was employed to estimate the cytoprotective effects of ten kinds of bioactive phytochemicals and their combinations. The results showed that allicin, proanthocyanidins, polyphenols, eleutherosides and isoflavones had higher antimutagenic activities than other phytochemicals. At the highest dose tested, the MTX genetoxicity was suppre

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Gaol, Agnes Della Lumban, and Sujarwati. "Phytochemical Profiling of Tampoi (Baccaurea macrocarpa (Miq.) Mull. Arg.) Leaves Using Liquid Chromatography-Tandem Mass Spectrometry." Jurnal Biologi Tropis 25, no. 3 (2025): 2577–83. https://doi.org/10.29303/jbt.v25i3.8964.

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Tampoi leaves (Baccaurea macrocarpa (Miq.) Mull. Arg.) have been reported to contain a diverse array of phytochemicals associated with various biological activities, including antioxidant and antibacterial effects, as well as the enhancement of erythrocyte and hemoglobin levels in anemic mouse models. This study aimed to comprehensively characterize the phytochemical profile of tampoi leaves to establish a foundation for elucidating the mechanisms underlying their biological activities. Extraction was conducted using a solid phase method with methanol as the solvent. Phytochemical profiling wa

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Abdullahi, Sharif Alhassan, Ngah Zasmy Unyah, Noshariza Nordin, et al. "Phytochemicals and Potential Therapeutic Targets on Toxoplasma gondii Parasite." Mini-Reviews in Medicinal Chemistry 20, no. 9 (2020): 739–53. http://dx.doi.org/10.2174/1389557519666191029105736.

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Identification of drug target in protozoan T. gondii is an important step in the development of chemotherapeutic agents. Likewise, exploring phytochemical compounds effective against the parasite can lead to the development of new drug agent that can be useful for prophylaxis and treatment of toxoplasmosis. In this review, we searched for the relevant literature on the herbs that were tested against T. gondii either in vitro or in vivo, as well as different phytochemicals and their potential activities on T. gondii. Potential activities of major phytochemicals, such as alkaloid, flavonoid, ter

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H, Shahzad. "Antioxidants from Bauhinia and Future Research Gap." Annals of Experimental and Molecular Biology 5, no. 1 (2023): 1–8. http://dx.doi.org/10.23880/aemb-16000118.

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Flower buds of Bauhinia are utilized as a human means of nourishment, and the stem and leaves serve as feed for livestock across the world. This chapter highlights the medicinal importance of various parts of Bauhinia plants. Bauhinia plants’ edible regions are an excellent source of phytochemicals that have notable potential as antioxidants. Various phytochemical compounds that include Saponins, glycosides (kaempferol-3-glucoside), cardiac glycosides, sterols (β-sitosterol), tannins, phenolics, alkaloids, terpenoids (Lupeol), quinones, flavanones and flavonoids reside in these plants. These p

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Usmani Rana, Hafiza Maria, Haseeb Nisar, Jignesh Prajapati, et al. "Integrative bioinformatic analysis to identify potential phytochemical candidates for glioblastoma." Heliyon 10, no. 24 (2024): e40744. https://doi.org/10.1016/j.heliyon.2024.e40744.

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Jahangeer, Muhammad, Ghulam Mustafa, Naveed Munir, Sibtain Ahmed, and Khalid Mashai Al-Anazi. "Exploring the Potential of Plant Bioactive Compounds against Male Infertility: An In Silico and In Vivo Study." Molecules 28, no. 23 (2023): 7693. http://dx.doi.org/10.3390/molecules28237693.

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Infertility is a well-recognized multifactorial problem affecting the majority of people who struggle with infertility issues. In recent times, among infertility cases, the male factor has acquired importance, and now it contributes to approximately half of the infertility cases because of different abnormalities. In the current study, we used natural phytochemicals as potential drug-lead compounds to target different receptor proteins that are involved in the onset of male infertility. A set of 210 plant phytochemicals were docked counter to active site residues of sex hormone-binding globuli

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Aloufi, Bandar Hamad. "Virtual Screening of Compounds for the Identification of Potential Drug Candidates Targeting the RACK1 Receptor in Liver Cancer." Advancements in Life Sciences 12, no. 1 (2025): 237. https://doi.org/10.62940/als.v12i1.3617.

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Background: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally and the sixth most common cancer, particularly in the Asia-Pacific and African regions. Liver cirrhosis, a critical precursor to HCC and liver failure, necessitates effective treatment options. Although surgical intervention is the current standard, there is a pressing need for novel therapeutics with improved efficacy and reduced side effects. This study focuses on RACK1 (Receptor for Activated C-Kinase 1), a pivotal protein in cancer progression, as a therapeutic target for HCC.Methods: Pr

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Fauzan, Irfan Anwar, Ditta Putri Kumalasari, and Nisrina Fitri Nurjannah. "In Silico Screening of Ruellia tuberosa Phytochemicals as Neuroimmune-Modulating Drug Candidates for Multiple Sclerosis Therapy." International Journal of Research and Review 12, no. 6 (2025): 536–40. https://doi.org/10.52403/ijrr.20250661.

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Multiple sclerosis (MS) is a chronic autoimmune disease characterized by neuroinflammation, demyelination, and progressive neurological decline. Current pharmacotherapies offer limited efficacy and often induce adverse effects, highlighting the need for safer, multi-target alternatives. This study employed an in silico approach to evaluate phytochemical compounds from Ruellia tuberosa as potential neuroimmune-modulating drug candidates for MS therapy. Five bioactive compounds, which are hentriacontane, nonacosane, campesterol, β-sitosterol, and stigmasterol, were identified through the KNApSAc

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Ramalingam, Shunmuga Vadivu, Senthil Bakthavatchalam, Karnan Ramachandran, et al. "Potential Antimicrobial and Cytotoxic Activity of Caralluma indica Seed Extract." Antibiotics 13, no. 12 (2024): 1193. https://doi.org/10.3390/antibiotics13121193.

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Background: Plant-derived phytochemicals are crucial in fighting bacterial infections and in cancer therapy. Objective: This study investigates the phytochemical composition of the ethanolic extract obtained from Caralluma indica (C. indica) seeds and assesses its antimicrobial, anticancer, and antioxidant activities. Results: GC-MS analysis found 30 phytochemicals in C. indica seeds, including 5 bioactive compounds that have been shown to have antioxidant, antimicrobial, and cytotoxicity properties, through in silico evaluation. Phytochemical screening of C. indica identified and measured the

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Nathan, Bharathi, and Sudheer M. M. Mohammed. "An insight into anti-arthritic property of phytochemicals against Rheumatoid arthritis using molecular modelling and docking approach." Research Journal of Biotechnology 16, no. 12 (2021): 185–95. http://dx.doi.org/10.25303/1612rjbt185195.

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Arthritis literally refers “joint inflammation”, it is a condition where one or more joints are inflamed. More than 100 different types of Arthritis were identified, most common types are rheumatoid arthritis and osteoarthritis. The present study mainly focuses on the development of the novel phytochemical inhibitors against rheumatoid arthritis and osteoarthritis using an integrative cheminformatics drug discovery platform. In this study, we identified potential 405 phytochemical drug candidates, screened against eight selected targets of rheumatoid arthritis and osteoarthritis using molecula

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Siregar, Yoga, Montesqrit, and Harnentis. "Potensi fitokimia daun belimbing wuluh (Averrhoa Bilimbi L.) dengan pengeringan berbeda sebagai kandidat antibiotik alami broiler." Agrivet : Jurnal Ilmu-Ilmu Pertanian dan Peternakan (Journal of Agricultural Sciences and Veteriner) 11, no. 1 (2023): 37–44. http://dx.doi.org/10.31949/agrivet.v11i1.5746.

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This study aimed to determine the phytochemical potential of belimbing wuluh leaves (Averrhoa bilimbi L.) as natural antibiotic candidates for broilers. Belimbing wuluh leaves were processed by drying them in direct sunlight, indirect sunlight, and an oven at 60 °C. The obtained data were descriptively analyzed. The parameters measured were the phytochemical screening test and the Escherichia coli antibacterial test. The results of the phytochemical screening test for starfruit leaves, indirect sunlight drying method, direct sunlight method, and 60 °C oven drying, positively contained phenolic

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16

Sameh, Salma, Eman Al-Sayed, Rola M. Labib, and Abdel Nasser Singab. "GenusSpondias: A Phytochemical and Pharmacological Review." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/5382904.

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It is believed that many degenerative diseases are due to oxidative stress. In view of the limited drugs available for treating degenerative diseases, natural products represent a promising therapeutic strategy in the search for new and effective candidates for treating degenerative diseases. This review focuses on the genusSpondiaswhich is widely used in traditional medicine for the treatment of many diseases.Spondiasis a genus of flowering plants belonging to the cashew family (Anacardiaceae). This genus comprises 18 species distributed across tropical regions in the world. A variety of bioa

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Harish, M., C. V. Ranjith, and C. Sethulekshmy Nair. "Effectiveness of Quercetin and Its Derivatives Against SARS CoV2 -In silico Approach." Journal of Experimental Biology and Agricultural Sciences 10, no. 5 (2022): 1003–15. http://dx.doi.org/10.18006/2022.10(5).1003.1015.

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The COVID-19 pandemic that erupted in November 2019 is continuing, with no effective antiviral agent to date. Synthetic antiviral agents have limitations such as a narrow range of therapeutic effectiveness of the activity, toxicity, and resistant viral strains and traditional antiviral medicines at large seem not to have these limitations. Here, some of the existing phytochemicals are cherry-picked for repurposing against the enzyme or protein targets of SARS CoV2, by the principles of structure-based drug design based on molecular docking studies. The most important drug targets of SARS CoV2

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18

Christopher Busayo Olowosoke, Adebola Abosede Alaba, and Benjamin Babatunde Adegboyega. "Citrullus lanatus natural product library: A hoard of viable potential inhibitor candidates for diabetes mellitus type II therapeutic target enzymes." World Journal of Advanced Research and Reviews 15, no. 1 (2022): 534–60. http://dx.doi.org/10.30574/wjarr.2022.15.1.0713.

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The ethnomedicinal function of several cucurbit species (cucumber, squash, melon, gourd, etc.) on diseases (i.e. diabetes, microbial infections, cancer, etc.), and as free radical scavengers have been reported. However, there remains infinitesimal record on citron watermelon broad use, which reflects the reason for wide oversight of underutilization, from lack of recognition for functional food crop development and commercialization. The objective of this study focus towards identifying the natural phytochemicals of C. lanatus on water melon molecules online database for insilico computational

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Christopher, Busayo Olowosoke, Abosede Alaba Adebola, and Babatunde Adegboyega Benjamin. "Citrullus lanatus natural product library: A hoard of viable potential inhibitor candidates for diabetes mellitus type II therapeutic target enzymes." World Journal of Advanced Research and Reviews 15, no. 1 (2022): 534–60. https://doi.org/10.5281/zenodo.7745429.

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The ethnomedicinal function of several cucurbit species (cucumber, squash, melon, gourd, etc.) on diseases (i.e. diabetes, microbial infections, cancer, etc.), and as free radical scavengers have been reported. However, there remains infinitesimal record on citron watermelon broad use, which reflects the reason for wide oversight of underutilization, from lack of recognition for functional food crop development and commercialization. The objective of this study focus towards identifying the natural phytochemicals of <em>C. lanatus</em> on water melon molecules online database for ins

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20

Semenescu, Alexandra-Denisa, Elena-Alina Moacă, Raul Chioibaş, et al. "Phytochemical and biological screening of aqueous Galium verum L. extract." Annals of the University Dunarea de Jos of Galati. Fascicle VI - Food Technology 47, no. 2 (2023): 172–89. http://dx.doi.org/10.35219/foodtechnology.2023.2.11.

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Plants are an important source of active compounds with numerous therapeutic benefits. Nowadays, plant extracts have attracted an increased attention as candidates in the prevention and treatment of various diseases, including cancer. Galium verum L. is considered an effective remedy due to its extensive traditional use, thus the investigation of its anticancer potential has gained momentum. Malignant melanoma is an aggressive type of cancer with an increased incidence. Therefore, the purpose of this paper was to analyze the cytotoxic effect of GvH2O extract on A375 cells. Furthermore, the saf

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Tatiya, Anilkumar U., and Pagar Pranali Anil. "A Comprehensive Review on the Role of Natural Plants in Anti-Bacterial Activity." Journal of Drug Delivery and Therapeutics 15, no. 7 (2025): 116–25. https://doi.org/10.22270/jddt.v15i7.7200.

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Natural plants have been an essential source of therapeutic agents for centuries. With the rising concern over antibiotic resistance, there is an increasing interest in exploring herbal plants as alternative sources of antibacterial agents. These plants contain a wide range of bioactive compounds that exhibit significant antibacterial properties, making them promising candidates for novel drug development. This review explores the various medicinal plants known for their antibacterial efficacy, their phytochemical constituents, and the mechanisms through which they exert their antibacterial ef

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Adnyana, I. Made Dwi Mertha, and Ni Luh Gede Sudaryati. "Phytochemical Analysis of the Antioxidant Compounds of Baper Tea and Its Potential as an Immunomodulatory agent and Candidate for Standardized Herbal Medicine." Trends in Sciences 20, no. 1 (2022): 6391. http://dx.doi.org/10.48048/tis.2023.6391.

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The antioxidant content of Baper tea was determined using phytochemical testing, and the potential of these contents as immunomodulatory agents and candidates for standardized herbal medications was investigated. A randomized design was used in this experimental study. Phytochemical assays are used to determine the antioxidant content of Baper tea, whereas organoleptic studies are performed using hedonic tests. A literature review was used to assess the content's potential as an immunomodulatory agent and candidate for standardized herbal medicine. The study lasted four months at the Biology a

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Alshammari, Ahmed Mohajja. "Molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds." Bioinformation 18, no. 9 (2022): 834–40. http://dx.doi.org/10.6026/97320630018834.

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It is of interest to document data on the molecular dynamics simulation analysis of alpha-cobratoxin docked with phytochemical compounds. This can be used as effective drug candidates against the snake and scorpion venom. It should be noted experimental verification is needed to further validate the current data.

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G. Bhavani Devi, K.S. Ramya, Dappula Sandhya Sri, P. Josthna, and C.V. Naidu. "Phytochemical screening study in different parts of Chromolaena odorata by LC MS method and related parameters." International Journal of Science and Research Archive 7, no. 2 (2022): 128–40. http://dx.doi.org/10.30574/ijsra.2022.7.2.0239.

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Chromolaena odorata (Syn: Eupatorium odoratum L.) (Asteraceae) is a perennial herb consisting of biologically potent chemical. It is mainly found in the humid tropics and sub-tropics in worldwide. C. odorata displayed allelopathic effects and have been reported to cause livestock death. C. odorata is used against dysentery, malaria, diarrhea, wound healing, toothache and headache in traditional medicine. In the present study, we investigated the assays tested for the presence of several phytochemicals (alkaloids, terpenoids, flavonoids, saponins, phenols, cardiac glycosides, resins and anthraq

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Vélez, Luis A., Yamixa Delgado, Yancy Ferrer-Acosta, Ivette J. Suárez-Arroyo, Priscilla Rodríguez, and Daraishka Pérez. "Theoretical Prediction of Gastrointestinal Absorption of Phytochemicals." International Journal of Plant Biology 13, no. 2 (2022): 163–79. http://dx.doi.org/10.3390/ijpb13020016.

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The discovery of bioactive compounds for non-invasive therapy has been the goal of research groups focused on pharmacotherapy. Phytonutrients have always been attractive for researchers because they are a significant source of bioactive phytochemicals. Still, it is challenging to determine which components show high biomedical activity and bioavailability after administration. However, based on the chemical structure of these phytochemicals, their physicochemical properties can be calculated to predict the probability of gastrointestinal (GI) absorption after oral administration. Indeed, diffe

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Indiastuti, Danti Nur, Nada Salsabila, Bellinda Zalzabillah Tazkira, Arifa Mustika, Suharjono, and Sukardiman. "In silico approach of Garcinia mangostana and Ortosiphon stamineus to restore adipokines level as drug candidate for metabolic syndrome." Pharmacy Education 24, no. 3 (2024): 159–65. http://dx.doi.org/10.46542/pe.2024.243.159165.

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Background: Metabolic syndrome is a group of metabolic disorders due to dysfunctional adipose tissue. Adipose tissue is an endocrine organ that secretes many pro-inflammatory and anti-inflammatory adipokines. Garcinia mangostana and Orthosiphon stamineus have demonstrated various pharmacological effects, including antidiabetic, anti-dyslipidemia, antiobesity, antioxidant, and anti-inflammatory properties. Objective: This study aimed to analyse the interaction of phytochemical compounds from Garcinia mangostana and Orthosiphon stamineus in decreasing levels of pro-inflammatory adipokines while

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Mahayana, Ngakan Putu Krishna, Ni Nyoman Ayu Dewi, I. Made Winarsa Ruma, and Desak Made Wihandani. "IN SILICO SCREENING OF PHYTOCHEMICAL COMPOUND AS NOVEL NOX1 INHIBITOR VIA INHIBITING P47PHOX-P22PHOX COMPLEX." E-Jurnal Medika Udayana 14, no. 2 (2025): 23. https://doi.org/10.24843/mu.2025.v14.i2.p05.

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The world’s elderly population is increasing. Thus, in the future, degenerative diseases incidence will increase. Therefore, the development of anti-aging agent is required. NADPH oxidase (NOX), especially NOX1, has important roles in aging and degenerative diseases. NOX1 activation required interaction between p47phox and p22phox subunit. Based on that mechanism, compound that has ability to inhibit p47phox-p22phox complex development could become an anti-aging agent. The aim of this study is to find novel NOX1 inhibitors candidate from phytochemical database that work via inhibiting p47phox-

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Daniyan, M. O., O. B. Adeoye, E. Osirim, and I. D. Asiyanbola. "The effect of bitter honey against cerebral malaria-induced inflammasome cell death: network pharmacology-based in silico evaluation." Biomeditsinskaya Khimiya 70, no. 6 (2024): 442–55. https://doi.org/10.18097/pbmc20247006442.

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Cerebral malaria (CM) is a fatal complication of Plasmodium falciparum infection. The biological and physiological links between CM, inflammation, and inflammasome, point to the complexity of its pathology. Resistance to available and affordable drugs, worsening economic crisis, and urgent need for integration of orthodox with traditional/alternative medicine, actualized the search for sustainable pharmacotherapy. Previous works from our team on the medicinal properties of bitter honey have established botanical and bioactive markers, inhibitory effects on pancreatic alpha-amylase activity, an

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Goyzueta-Mamani, Luis Daniel, Haruna Luz Barazorda-Ccahuana, Karel Mena-Ulecia, and Miguel Angel Chávez-Fumagalli. "Antiviral Activity of Metabolites from Peruvian Plants against SARS-CoV-2: An In Silico Approach." Molecules 26, no. 13 (2021): 3882. http://dx.doi.org/10.3390/molecules26133882.

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(1) Background: The COVID-19 pandemic lacks treatments; for this reason, the search for potential compounds against therapeutic targets is still necessary. Bioinformatics tools have allowed the rapid in silico screening of possible new metabolite candidates from natural resources or repurposing known ones. Thus, in this work, we aimed to select phytochemical candidates from Peruvian plants with antiviral potential against three therapeutical targets of SARS-CoV-2. (2) Methods: We applied in silico technics, such as virtual screening, molecular docking, molecular dynamics simulation, and MM/GBS

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Mahmud, Shafi, Suvro Biswas, Gobindo Kumar Paul, et al. "Plant-Based Phytochemical Screening by Targeting Main Protease of SARS-CoV-2 to Design Effective Potent Inhibitors." Biology 10, no. 7 (2021): 589. http://dx.doi.org/10.3390/biology10070589.

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Currently, a worldwide pandemic has been declared in response to the spread of coronavirus disease 2019 (COVID-19), a fatal and fast-spreading viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The low availability of efficient vaccines and treatment options has resulted in a high mortality rate, bringing the world economy to its knees. Thus, mechanistic investigations of drugs capable of counteracting this disease are in high demand. The main protease (Mpro) expressed by SARS-CoV-2 has been targeted for the development of potential drug candidates due to t

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S, Selvapraba, Venkatachalam T, and N. Senthil Kumar. "In Silico Evaluation of Selected Phytochemicals for Anti-nCovid Potential Based on Molecular Docking Studies and Their Pharmacokinetics and Drug-likeness Predictions." Der Pharma Chemica 14, no. 8 (2022): 12. https://doi.org/10.4172/0975-413X.14.8.36-47.

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SARS-CoV-2 has devastated the world with its rapid spread and fatality. Pharmaceutical giants respective of their market has stretched towards research and enhancing the productive capacities of their units to meet the unprecedented drug demand. Drug discovery approaches involving all in silico, in vitro, in vivo approaches to design and develop has fastened. The present work explains in-silico drug discovery methods like molecular docking and molecular dynamic simulations to screen for highly probable, safe, and effective phytochemical principles against SARSCoV-2. Docking of various phytoche

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Chakrabarty, Susmita, Shasank S. Swain, and Monali Priyadarsini Mishra. "Quantitative Phytochemical Investigation, Antibacterial Potency, and Drug-ability Assessment of Three Indian Medicinal Plants Leaf Extracts Using Bioinformatics Tools." International Journal of Experimental Research and Review 42 (August 30, 2024): 351–64. http://dx.doi.org/10.52756/ijerr.2024.v42.031.

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Natural regimens have long-held ethnomedicinal values, serving as primary sources for mainstream medicine. Therefore, scientists are paying more attention to studying the biological activity of existing plant species in organized ways to select potent bioactive metabolites to use for specific therapeutic purposes. This study used the same approach to find potent antibacterial phytoconstituents in three well-known Indian medicinal plants: Psidium guajava L., Syzygium cumini L. and Punica granatum L. In the earlier study, methanolic leaf extracts of the above plant extracts were more effective t

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Verdú, José R., Vieyle Cortez, Rocío Rosa-García, et al. "Nontoxic effects of thymol, carvacrol, cinnamaldehyde, and garlic oil on dung beetles: A potential alternative to ecotoxic anthelmintics." PLOS ONE 18, no. 12 (2023): e0295753. http://dx.doi.org/10.1371/journal.pone.0295753.

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The sustainability of the traditional extensive livestock sector will only be possible if healthy dung-decomposing insect communities are preserved. However, many current pharmaceutical anthelmintics are harmful to dung beetles, their presence can have a negative impact on biological systems. Phytochemical anthelmintics are an alternative to ecotoxic synthetic pharmaceutical anthelmintics, although ecotoxicological tests of their possible indirect effects on dung beetles are required to demonstrate their viability. In this study, the potential ecotoxicity of thymol, carvacrol, cinnamaldehyde a

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Ameen, Hazeena M., Ayona Jayadev, Geena Prasad, and Deepa Indira Nair. "Seagrass Meadows: Prospective Candidates for Bioactive Molecules." Molecules 29, no. 19 (2024): 4596. http://dx.doi.org/10.3390/molecules29194596.

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Seagrass meadows consist of angiosperms that thrive fully submerged in marine environments and form distinct ecosystems. They provide essential support for many organisms, acting as nursery grounds for species of economic importance. Beyond their ecological roles, seagrasses and their associated microbiomes are rich sources of bioactive compounds with the potential to address numerous human healthcare challenges. Seagrasses produce bioactive molecules responding to physical, chemical, and biological environmental changes. These activities can treat microbe-borne diseases, skin diseases, diabet

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Adekunle, Olutoyin, Temitope Adelusi, Ismaila Sule, Akanmidu Olorunfemi, Halimat Abdulrahim, and Adeniran Adekunle. "Phytochemical Analyses, Antimicrobial Activities and Possible Antimicrobial Mechanism of Adansonia Digitata: An Animal Model." Alexandria Journal of Veterinary Sciences 74, no. 2 (2022): 50. http://dx.doi.org/10.5455/ajvs.50029.

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Development of resistance to reference antibiotics leading to increased mortality have caused critical concern in the management of infectious diseases. Continuous search for alternative therapies have shown good candidates in medicinal plants, although without thorough examination of possible mechanism of action. This study assessed the phytochemical constituents, antimicrobial activities and possible antimicrobial mechanism of Adansonia digitata, against Shigella flexneri, Escerichia Coli and Salmonella enteritis.

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Echiburú-Chau, C., C. Salas, M. Cuellar, et al. "830: Phytochemical extract from Senecio graveolens (Chachacoma): Searching new candidates for anti-cancer drugs." European Journal of Cancer 50 (July 2014): S201. http://dx.doi.org/10.1016/s0959-8049(14)50733-2.

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Rinthong, Prasoborn, Pawitra Pulbutr, and Chawannuch Mudjupa. "Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme." Journal of Herbmed Pharmacology 12, no. 2 (2023): 262–70. http://dx.doi.org/10.34172/jhp.2023.28.

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Introduction: Triphala, consisting of three fruits, Phyllanthus emblica L. (Phyllanthaceae), Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and T. chebula Retz, is a well-recognized Ayurvedic herbal formulation, used for various therapeutic purposes, including the treatment of dyslipidemia. Inhibitory activity against 3‑hydroxy‑3‑methylglutaryl‑coenzyme A (HMG‑CoA) reductase, a rate-limiting enzyme in the endogenous cholesterol synthesis pathway, is an essential target for the management of hypercholesterolemia. This in silico study aimed to investigate the HMG-CoA reductase inhibitory a

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Pritha, Halder1 Tapan Kumar Chatterjee2*. "Indian Medicinal Plants Having Anti-Cancer Properties." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 898–920. https://doi.org/10.5281/zenodo.14323876.

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These days, cancer is one of the deadliest disorders in the world, which has been estimated to cause 9.9 million passings in 2020. Customary medicines for cancer commonly include mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy.  In any case, the negative side impacts of these approaches have been broadly detailed and have provoked the look of unused helpful drugs. In this context, the scientific community has begun to look for inventive sources of anticancer compounds in conventional plants. Various studies have assessed the anticancer properties of common compoun

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Davinelli, Sergio, Nadia Sapere, Davide Zella, Renata Bracale, Mariano Intrieri, and Giovanni Scapagnini. "Pleiotropic Protective Effects of Phytochemicals in Alzheimer's Disease." Oxidative Medicine and Cellular Longevity 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/386527.

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Alzheimer’s disease (AD) is a severe chronic neurodegenerative disorder of the brain characterised by progressive impairment in memory and cognition. In the past years an intense research has aimed at dissecting the molecular events of AD. However, there is not an exhaustive knowledge about AD pathogenesis and a limited number of therapeutic options are available to treat this neurodegenerative disease. Consequently, considering the heterogeneity of AD, therapeutic agents acting on multiple levels of the pathology are needed. Recent findings suggest that phytochemicals compounds with neuroprot

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Saha, Shuvo, Partha Biswas, Mohaimenul Islam Tareq та ін. "Pharmacoinformatics, Molecular Dynamics Simulation, and Quantum Mechanics Calculation Based Phytochemical Screening of Croton bonplandianum Against Breast Cancer by Targeting Estrogen Receptor-α (ERα)". Applied Sciences 14, № 21 (2024): 9878. http://dx.doi.org/10.3390/app14219878.

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Breast cancer progression is strongly influenced by estrogen receptor-α (ERα), a ligand-activated transcription factor that regulates hormone binding, DNA interaction, and transcriptional activation. ERα plays a key role in promoting cell proliferation in breast tissue, and its overexpression is associated with the advancement of breast cancer through estrogen-mediated signaling pathways. Targeting ERα is, therefore, a promising therapeutic strategy for breast cancer. However, there are currently no phytochemical-based drug candidates approved for effectively inhibiting breast cancer progressi

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Bashir, Salim Faruk, and Gaurav Kumar. "Preliminary phytochemical screening and in vitro antibacterial activity of Plumbago indica (Laal chitrak) root extracts against drug-resistant Escherichia coli and Klebsiella pneumoniae." Open Agriculture 6, no. 1 (2021): 435–44. http://dx.doi.org/10.1515/opag-2021-0026.

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Abstract Drug resistance is one of the problems affecting the world where drug-resistant Escherichia coli and Klebsiella pneumoniae have been shown to be ubiquitous, frequently isolated from foods and commonly associated with surgical site infection in hospitals worldwide. The aims of this work were to analyze the antibacterial activity of root extracts of the plant obtained by serial extraction (using petroleum ether, chloroform, methanol, and water) and by in vitro techniques and preliminary screen phytochemicals present in the extract by qualitative means. Fresh roots of Plumbago indica wer

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Asuzu, Peace C., Nicholas S. Trompeter, Carlton R. Cooper, Samuel A. Besong, and Alberta N. A. Aryee. "Cell Culture-Based Assessment of Toxicity and Therapeutics of Phytochemical Antioxidants." Molecules 27, no. 3 (2022): 1087. http://dx.doi.org/10.3390/molecules27031087.

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Plant-derived natural products are significant resources for drug discovery and development including appreciable potentials in preventing and managing oxidative stress, making them promising candidates in cancer and other disease therapeutics. Their effects have been linked to phytochemicals such as phenolic compounds and their antioxidant activities. The abundance and complexity of these bio-constituents highlight the need for well-defined in vitro characterization and quantification of the plant extracts/preparations that can translate to in vivo effects and hopefully to clinical use. This

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Amin, Elham, Enas I. A. Mohamed, Amani Salem Alenezi, et al. "Pattern Recognition of Phytoconstituents and Bioactivities of Date Pit Extracts from Different Cultivars Grown in the Qassim Area." Separations 10, no. 2 (2023): 102. http://dx.doi.org/10.3390/separations10020102.

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A huge number of date varieties grow annually throughout the world. The genetic variation between different date varieties is reflected in their variable sensory characters and phytochemical contents. Date pits are considered a waste product of the date industry, despite their rich metabolic content. The present study attempts to generate visual clustering to clarify the diversity among fourteen date cultivars growing in the Qassim region, according to the phytochemical contents and biological potentials of their pits. The results indicated a wide variation in the total phenolic content (11.4–

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Rahman, Nur Afanin, and Sadhilah Humaerah. "An Innovative Herbal Hair Tonic Derived from Purslane (Portulaca oleracea) Extract." Cognitia : International Engineering Journal 1, no. 1 (2025): 26–33. https://doi.org/10.63288/ciej.v1i1.4.

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The rising demand for natural and eco-friendly personal care products has driven innovation in plant-based formulations. Portulaca species, rich in bioactive compounds, are potential candidates for use in hair tonic products due to their hair growth-promoting properties. This study aims to analyze the phytochemical content of two Portulaca species and evaluate the effects of extract concentration on hair tonic formulation quality; Methods or process: The research was conducted at the Research Laboratory of FTI-UMI and involved several steps: sample preparation, extraction using the Soxhlet met

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Hsieh, Edward M., May R. Berenbaum, and Adam G. Dolezal. "Ameliorative Effects of Phytochemical Ingestion on Viral Infection in Honey Bees." Insects 11, no. 10 (2020): 698. http://dx.doi.org/10.3390/insects11100698.

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Honey bee viruses are capable of causing a wide variety of devastating effects, but effective treatments have yet to be discovered. Phytochemicals represent a broad range of substances that honey bees frequently encounter and consume, many of which have been shown to improve honey bee health. However, their effect on bee viruses is largely unknown. Here, we tested the therapeutic effectiveness of carvacrol, thymol, p-coumaric acid, quercetin, and caffeine on viral infection by measuring their ability to improve survivorship in honey bees inoculated with Israeli acute paralysis virus (IAPV) usi

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Almarzooqi, Saeeda, Balaji Venkataraman, Vishnu Raj та ін. "β-Myrcene Mitigates Colon Inflammation by Inhibiting MAP Kinase and NF-κB Signaling Pathways". Molecules 27, № 24 (2022): 8744. http://dx.doi.org/10.3390/molecules27248744.

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Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). The incidence of IBD is rising globally. However, the etiology of IBD is complex and governed by multiple factors. The current clinical treatment for IBD mainly includes steroids, biological agents and need-based surgery, based on the severity of the disease. Current drug therapy is often associated with adverse effects, which limits its use. Therefore, it necessitates the search for new drug candidates. In this pursuit, phytochemicals take the lead in the search

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Jamal, Adil, Amina Arif, Muhammad Naveed Shahid, Shumaila Kiran, and Zunaira Batool. "Plant Secondary Metabolites Inhibit Cancer by Targeting Epidermal Growth Factor Receptor (EGFR): An Updated Review on their Regulation and Mechanisms of Action." Asian Pacific Journal of Cancer Biology 10, no. 1 (2025): 191–206. https://doi.org/10.31557/apjcb.2025.10.1.191-206.

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Cancer is an exceedingly pervasive disease currently, with approximately 14 million individuals diagnosed every year. The lifestyle and environmental changes are the most widespread causes of cancer. There are numerous cancer treatments available, including chemotherapy, radiotherapy, and hormone therapies. However, these procedures have adverse effects. In such circumstances, plant-based therapies have shown increased efficacy. Plant secondary metabolites such as alkaloids, polyphenols, cannabinoids, and flavonoids have anti-inflammatory, anti-tumor, and anti-proliferative properties, making

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Maharani, Maharani, Berna Elya, and Roshamur Cahyan Forestrania. "Characterization of Phytocomponents of Mindi Leaf Extract and Chinese Petai Seeds by LC-HRMS and In Silico Activity Against Alpha-glucosidase." Jurnal Ilmiah Kesehatan (JIKA) 6, no. 2 (2024): 285–99. http://dx.doi.org/10.36590/jika.v6i2.1007.

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Melia azedarach L. and Leucaena leucocephala L. were two plant species that had attracted attention in phytochemical research due to their bioactive potential. However, research on the phytochemical characterization using Liquid Chromatography – High-Resolution Mass Spectrometry (LC-HRMS) of these two plants was still limited. This study was to identify and characterize the phytochemical properties of Mindi leaves (Melia azedarach L.) and Chinese Petai seeds (Leucaena leucocephala L.), as well as to conduct an in silico study. The research method involved reflux extraction using 70% ethanol as

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M.K., Geetha Nambiar, and Ahamed T. K. Shameera. "Investigating Antibacterial Activities of Phytochemicals from Terminalia chebula and Terminalia bellirica fruit extract: An in vitro and in silico Study." Research Journal of Chemistry and Environment 28, no. 7 (2024): 50–60. http://dx.doi.org/10.25303/287rjce050060.

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This study aims to investigate the antibacterial activities of phytochemicals derived from Terminalia chebula (T. Chebula) and Terminalia bellirica (T. bellirica) through a combined approach of in vitro and in silico analyses. T. chebula and T. bellirica are medicinal plants widely recognized for their therapeutic properties and have been traditionally used to treat various infectious diseases. The potential antibacterial properties of these plants have drawn significant interest in recent years. In the in vitro phase of the study, crude extracts of dried fruit of T. chebula and T. bellirica a

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Aprian, Fakhrizal Dwi, Syamsudin Syamsudin, Sarah Zaidan, Deny Susanti, and Zainur Rahman Hakim. "BSLT Toxicity Test Of Temulawak Ethanol Extract (Curcuma Xanthorrhiza) From Five Different Regions And Determination Of Curcumin And Xanthorhizol Compound Levels." OPSearch: American Journal of Open Research 2, no. 12 (2023): 828–38. http://dx.doi.org/10.58811/opsearch.v2i12.89.

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The BSLT toxicity test is a preliminary test to look for ingredients that have the potential to act as anticancer from natural ingredients. A natural ingredient that has the potential to be an anticancer candidate is ginger. The aim of this research is to determine the level of toxicity against Artemia salina and look for anticancer candidates from ginger originating from different regions based on their toxicity, establish quality standards and determine the levels of curcumin and xanthorrhizol from extracts that have the highest toxicity. This research made 50% ethanol extract of ginger from

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