To see the other types of publications on this topic, follow the link: Phytochemicals - Therapeutic use.
Journal articles on the topic 'Phytochemicals - Therapeutic use'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Phytochemicals - Therapeutic use.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Harrison, Andrew M., Fabrice Heritier, Bennett G. Childs, J. Michael Bostwick, and Mikhail A. Dziadzko. "Systematic Review of the Use of Phytochemicals for Management of Pain in Cancer Therapy." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/506327.
Full textAbstract:
Pain in cancer therapy is a common condition and there is a need for new options in therapeutic management. While phytochemicals have been proposed as one pain management solution, knowledge of their utility is limited. The objective of this study was to perform a systematic review of the biomedical literature for the use of phytochemicals for management of cancer therapy pain in human subjects. Of an initial database search of 1,603 abstracts, 32 full-text articles were eligible for further assessment. Only 7 of these articles met all inclusion criteria for this systematic review. The average relative risk of phytochemical versus control was 1.03 [95% CI 0.59 to 2.06]. In other words (although not statistically significant), patients treated with phytochemicals were slightly more likely than patients treated with control to obtain successful management of pain in cancer therapy. We identified a lack of quality research literature on this subject and thus were unable to demonstrate a clear therapeutic benefit for either general or specific use of phytochemicals in the management of cancer pain. This lack of data is especially apparent for psychotropic phytochemicals, such as theCannabisplant (marijuana). Additional implications of our findings are also explored.
2
Dey, Priyankar, Somit Dutta, Anurag Chowdhury, Abhaya Prasad Das, and Tapas Kumar Chaudhuri. "Variation in Phytochemical Composition Reveals Distinct Divergence of Aloe vera (L.) Burm.f. From Other Aloe Species: Rationale Behind Selective Preference of Aloe vera in Nutritional and Therapeutic Use." Journal of Evidence-Based Complementary & Alternative Medicine 22, no. 4 (March 23, 2017): 624–31. http://dx.doi.org/10.1177/2156587217698292.
Full textAbstract:
In the present study, we have phytochemically characterized 5 different abundant Aloe species, including Aloe vera (L.) Burm.f., using silylation followed by Gas Chromatography-Mass Spectrometry technique and compared the data using multivariate statistical analysis. The results demonstrated clear distinction of the overall phytochemical profile of A vera, highlighted by its divergent spatial arrangement in the component plot. Lowest correlation of the phytochemical profiles were found between A vera and A aristata Haw. (−0.626), whereas highest correlation resided between A aristata and A aspera Haw. (0.899). Among the individual phytochemicals, palmitic acid was identified in highest abundance cumulatively, and carboxylic acids were the most predominant phytochemical species in all the Aloe species. Compared to A vera, linear correlation analysis revealed highest and lowest correlation with A aspera ( R2 = 0.9162) and A aristata ( R2 = 0.6745), respectively. Therefore, A vera demonstrated distinct spatial allocation, reflecting its greater phytochemical variability.
3
Bidlack, Wayne R. "Tyler’s Herbs of Choice: The Therapeutic Use of Phytochemicals." Journal of the American College of Nutrition 20, no. 3 (June 2001): 265–66. http://dx.doi.org/10.1080/07315724.2001.10719043.
Full text
4
Innocent Izuchukwu Ujah, Chukwunonso Anthony Nsude, Onuabuchi Nnenna Ani, Uchenna Blessing Alozieuwa, Innocent Oluwaseun Okpako, and Amos Ejiofor Okwor. "Phytochemicals of neem plant (Azadirachta indica) explains its use in traditional medicine and pest control." GSC Biological and Pharmaceutical Sciences 14, no. 2 (February 28, 2021): 165–71. http://dx.doi.org/10.30574/gscbps.2021.14.2.0394.
Full textAbstract:
Neem Azadirachta indica is a useful traditional medicinal plant growing in Nigeria, India, and America. The phytochemicals and the biopesticidal components present were ascertained. The results showed that saponins, steroids and terpenes were mostly present, while tannins and glycosides were moderately present, and alkaloids, flavonoids, phenols and oxalic acid were least present. The presence of these phytochemical could account for the therapeutic uses of neem.
5
Lee, Tzu-Ying, and Yu-Hsin Tseng. "The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence." Biomolecules 10, no. 8 (August 6, 2020): 1150. http://dx.doi.org/10.3390/biom10081150.
Full textAbstract:
The etiological factors of oral cancer are complex including drinking alcohol, smoking tobacco, betel quid chewing, human papillomavirus infection, and nutritional deficiencies. Understanding the molecular mechanism of oral cancer is vital. The traditional treatment for patients with oral squamous cell carcinoma (e.g., surgery, radiotherapy, and chemotherapy) and targeted molecular therapy still have numerous shortcomings. In recent years, the use of phytochemical factors to prevent or treat cancer has received increasing attention. These phytochemicals have little or no toxicity against healthy tissues and are thus ideal chemopreventive agents. However, phytochemicals usually have low water solubility, low bioavailability, and insufficient targeting which limit therapeutic use. Numerous studies have investigated the development of phytochemical delivery systems to address these problems. The present article provides an overview of oral cancer including the etiological factors, diagnosis, and traditional therapy. Furthermore, the classification, dietary sources, anticancer bioactivity, delivery system improvements, and molecular mechanisms against oral cancer of phytochemicals are also discussed in this review.
6
Ahmad, Syed Sayeed, Tayyaba Waheed, Sayed Rozeen, Sufia Mahmood, and Mohammad Amjad Kamal. "Therapeutic Study of Phytochemicals Against Cancer and Alzheimer’s Disease Management." Current Drug Metabolism 20, no. 13 (January 23, 2020): 1006–13. http://dx.doi.org/10.2174/1389200221666200103092719.
Full textAbstract:
Background: Phytochemicals are a significant piece of conventional prescription and have been researched in detail for conceivable consideration in current drug discovery. Medications and plants are firmly identified for traditional prescriptions and ethnomedicines that are basically arranged from plants. Recognizing the medical advantages of phytochemicals is of fundamental advancement in medication and useful sustenance improvement. Secondary metabolites of different plants have been customarily used for the improvement of human wellbeing. The phytochemicals are diets rich, which can upgrade neuroplasticity and protection from neurodegeneration. Results: Phytochemicals keep on entering clinical preliminaries or provide leads for the synthesis of medicinal agents. Phytochemicals are a great extent cancer prevention agents in nature at lower concentrations and under favorable cell conditions that adequately avoid the oxidation of different molecules that have an ability to produce free radicals and thus protect the body. Conclusion: The purpose of this review is to describe the use of phytochemicals against cancer and Alzheimer’s disease treatment.
7
Lee, Gihyun, and Hyunsu Bae. "Therapeutic Effects of Phytochemicals and Medicinal Herbs on Depression." BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/6596241.
Full textAbstract:
Background. Depression is a recurrent, common, and potentially life-threatening psychiatric disease related to multiple assignable causes. Although conventional antidepressant therapy can help relieve symptoms of depression and prevent relapse of the illness, complementary therapies are required due to disadvantage of the current therapy such as adverse effects. Moreover, a number of studies have researched adjunctive therapeutic approaches to improve outcomes for depression patients. Purpose. One potential complementary method with conventional antidepressants involves the use of medicinal herbs and phytochemicals that provide therapeutic benefits. Studies have revealed beneficial effects of medical herbs and phytochemicals on depression and their central nervous system mechanism. Here, we summarize the current knowledge of the therapeutic benefits of phytochemicals and medicinal herbs against depression and describe their detailed mechanisms. Sections. There are two sections, phytochemicals against depression and medical herbs against depression, in this review. Conclusion. Use of phytomedicine may be an alternative option for the treatment of depression in case conventional drugs are not applicable due to their side effects, low effectiveness, or inaccessibility. However, the efficacy and safety of these phytomedicine treatments for depression have to be supported by clinical studies.
8
Heng, Win Sen, Frank A. E. Kruyt, and Shiau-Chuen Cheah. "Understanding Lung Carcinogenesis from a Morphostatic Perspective: Prevention and Therapeutic Potential of Phytochemicals for Targeting Cancer Stem Cells." International Journal of Molecular Sciences 22, no. 11 (May 27, 2021): 5697. http://dx.doi.org/10.3390/ijms22115697.
Full textAbstract:
Lung cancer is still one of the deadliest cancers, with over two million incidences annually. Prevention is regarded as the most efficient way to reduce both the incidence and death figures. Nevertheless, treatment should still be improved, particularly in addressing therapeutic resistance due to cancer stem cells—the assumed drivers of tumor initiation and progression. Phytochemicals in plant-based diets are thought to contribute substantially to lung cancer prevention and may be efficacious for targeting lung cancer stem cells. In this review, we collect recent literature on lung homeostasis, carcinogenesis, and phytochemicals studied in lung cancers. We provide a comprehensive overview of how normal lung tissue operates and relate it with lung carcinogenesis to redefine better targets for lung cancer stem cells. Nine well-studied phytochemical compounds, namely curcumin, resveratrol, quercetin, epigallocatechin-3-gallate, luteolin, sulforaphane, berberine, genistein, and capsaicin, are discussed in terms of their chemopreventive and anticancer mechanisms in lung cancer and potential use in the clinic. How the use of phytochemicals can be improved by structural manipulations, targeted delivery, concentration adjustments, and combinatorial treatments is also highlighted. We propose that lung carcinomas should be treated differently based on their respective cellular origins. Targeting quiescence-inducing, inflammation-dampening, or reactive oxygen species-balancing pathways appears particularly interesting.
9
Kang, Hara. "MicroRNA-Mediated Health-Promoting Effects of Phytochemicals." International Journal of Molecular Sciences 20, no. 10 (May 23, 2019): 2535. http://dx.doi.org/10.3390/ijms20102535.
Full textAbstract:
Phytochemicals are known to benefit human health by modulating various cellular processes, including cell proliferation, apoptosis, and inflammation. Due to the potential use of phytochemicals as therapeutic agents against human diseases such as cancer, studies are ongoing to elucidate the molecular mechanisms by which phytochemicals affect cellular functions. It has recently been shown that phytochemicals may regulate the expression of microRNAs (miRNAs). MiRNAs are responsible for the fine-tuning of gene expression by controlling the expression of their target mRNAs in both normal and pathological cells. This review summarizes the recent findings regarding phytochemicals that modulate miRNA expression and promote human health by exerting anticancer, photoprotective, and anti-hepatosteatosis effects. Identifying miRNAs modulated by phytochemicals and understanding the regulatory mechanisms mediated by their target mRNAs will facilitate the efforts to maximize the therapeutic benefits of phytochemicals.
10
Asanaliyar, Meharban, and Pratibha Nadig. "Syzygium cumini (jamun) therapeutic potential: a comprehensive review on phytochemical constituents and emphasis on its pharmacological actions related to diabetic intervention." International Journal of Basic & Clinical Pharmacology 9, no. 2 (January 24, 2020): 363. http://dx.doi.org/10.18203/2319-2003.ijbcp20200192.
Full textAbstract:
Syzygium cumini or Eugenia Jambolana Lam is a traditional medicinal plant very native to the Indian and Asian sub-continent. It is commonly known as black plum or jamun. Various plants parts of the tree are known for ethno-medicinal uses, and in particular, the fruits of Jamun tree are well known for medicinal uses and preparation of health drinks. Studies have shown that the berries contain carbohydrates, minerals and the pharmacologically active phytochemicals. The active phytochemical includes flavonoids, terpenes, and anthocyanins. Ayurvedic and Indian Folk Medicine have already mentioned the use of jamun for diabetic treatment even before the advent of insulin. The bark, fruit pulp, seeds and the leaves are evaluated in the crude form as well as extracts in various diabetic models. Further, bioactive phytochemicals are extracted using in vitro assays, some of them such as vitalboside-A, mycominose are also characterized with spectroscopic analysis. This review article is intended to compile Syzygium cumini’s therapeutic potential with special emphasis on the phytochemical constituents and its pharmacological activities related to diabetic intervention through recent studies conducted in last one decade. It also addresses the clinical and toxicological studies.
11
Arafah, Azher, Muneeb U. Rehman, Tahir Maqbool Mir, Adil Farooq Wali, Rayeesa Ali, Wajhul Qamar, Rehan Khan, et al. "Multi-Therapeutic Potential of Naringenin (4′,5,7-Trihydroxyflavonone): Experimental Evidence and Mechanisms." Plants 9, no. 12 (December 16, 2020): 1784. http://dx.doi.org/10.3390/plants9121784.
Full textAbstract:
Extensive research has been carried out during the last few decades, providing a detailed account of thousands of discovered phytochemicals and their biological activities that have the potential to be exploited for a wide variety of medicinal purposes. These phytochemicals, which are pharmacologically important for clinical use, primarily consist of polyphenols, followed by terpenoids and alkaloids. There are numerous published reports indicating the primary role of phytochemicals proven to possess therapeutic potential against several diseases. However, not all phytochemicals possess significant medicinal properties, and only some of them exhibit viable biological effects. Naringenin, a flavanone found in citrus fruits, is known to improve immunity, repair DNA damage, and scavenge free radicals. Despite the very low bioavailability of naringenin, it is known to exhibit various promising biological properties of medicinal importance, including anti-inflammatory and antioxidant activities. This review focuses on the various aspects related to naringenin, particularly its physicochemical, pharmacokinetic, and pharmacodynamic properties. Furthermore, various pharmacological activities of naringenin, such as anticancer, antidiabetic, hepatoprotective, neuroprotective, cardioprotective, nephroprotective, and gastroprotective effects, have been discussed along with their mechanisms of action.
12
Koiri, Raj Kumar, and Aditi Mehrotra. "Network-based Drug Discovery, Anti-cancer Molecular Targets and Therapeutic use of Phytochemicals." Anti-Cancer Agents in Medicinal Chemistry 18, no. 13 (February 14, 2019): 1794–95. http://dx.doi.org/10.2174/187152061813190117122219.
Full text
13
Kumaran, Dr T. "A Review of Recent Studies on The Phytochemical and Pharmacological Activity of Annona Muricata." Forestry & Agriculture Review 2, no. 1 (January 10, 2021): 1–5. http://dx.doi.org/10.47285/far.v2i1.31.
Full textAbstract:
Medicinal plants have been used to treat illness and disease for thousands of years. Bioactive principles present in medicinal plants attribute to the therapeutic efficacy and it can be incorporated into modern medicine systems for the development of newer drug formulation for therapeutic ailments. Even now they are economically important, being used in the pharmaceutical, cosmetic, perfumery, and food industries. Screening of medicinal plants for antimicrobial activities and phytochemicals is important for finding potential new compounds for therapeutic use. In the present review, an attempt has been made to congregate the traditional, phytochemical, and pharmacological studies done on an important medicinal plant Annona muricata. Cyclo hexapeptides, acetogenins, annonaceous acetogenins were the major phytochemical compounds studied from this medicinal plant. The fruit is of economic value and hence cultivated and used widely as edible food. The plant possesses the major pharmacological activities includes Anti-viral activity, Anti-oxidant Activity, Larvicidal activity, Anti-inflammatory activity, Antipediculicidal activity, Anti-bacterial activity, and wound healing. It also has an anti-carcinogenic and cytotoxic effect.
14
Upadhyay, Swapna, and Madhulika Dixit. "Role of Polyphenols and Other Phytochemicals on Molecular Signaling." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/504253.
Full textAbstract:
Optimized nutrition through supplementation of diet with plant derived phytochemicals has attracted significant attention to prevent the onset of many chronic diseases including cardiovascular impairments, cancer, and metabolic disorder. These phytonutrients alone or in combination with others are believed to impart beneficial effects and play pivotal role in metabolic abnormalities such as dyslipidemia, insulin resistance, hypertension, glucose intolerance, systemic inflammation, and oxidative stress. Epidemiological and preclinical studies demonstrated that fruits, vegetables, and beverages rich in carotenoids, isoflavones, phytoestrogens, and phytosterols delay the onset of atherosclerosis or act as a chemoprotective agent by interacting with the underlying pathomechanisms. Phytochemicals exert their beneficial effects either by reducing the circulating levels of cholesterol or by inhibiting lipid oxidation, while others exhibit anti-inflammatory and antiplatelet activities. Additionally, they reduce neointimal thickening by inhibiting proliferation of smooth muscle cells and also improve endothelium dependent vasorelaxation by modulating bioavailability of nitric-oxide and voltage-gated ion channels. However, detailed and profound knowledge on specific molecular targets of each phytochemical is very important to ensure safe use of these active compounds as a therapeutic agent. Thus, this paper reviews the active antioxidative, antiproliferative, anti-inflammatory, or antiangiogenesis role of various phytochemicals for prevention of chronic diseases.
15
Pham, Hong Ngoc Thuy, Quan Van Vuong, Michael C. Bowyer, and Christopher J. Scarlett. "Phytochemicals Derived from Catharanthus roseus and Their Health Benefits." Technologies 8, no. 4 (December 21, 2020): 80. http://dx.doi.org/10.3390/technologies8040080.
Full textAbstract:
Catharanthus roseus (C. roseus) is an important medicinal plant distributed in many countries. It has attracted increasing attention due to it being shown to possess a range of phytochemicals with various biological activities such as antioxidant, antibacterial, antifungal, antidiabetic and anticancer properties. Remarkably, vinblastine and vincristine isolated from this plant were the first plant-derived anticancer agents deployed for clinical use. Recently, new isolated indole alkaloids from this plant including catharoseumine, 14′,15′-didehydrocyclovinblastine, 17-deacetoxycyclovinblastine and 17-deacetoxyvinamidine effectively inhibited human cancer cell lines in vitro. Moreover, vindoline, vindolidine, vindolicine and vindolinine isolated from C. roseus leaf exhibited in vitro antidiabetic property. These findings strongly indicate that this plant is still a promising source of bioactive compounds, which should be further investigated. This paper provides an overview of the traditional use and phytochemical profiles of C. roseus, and summarises updated techniques of the preparation of dried material, extraction and isolation of bioactive compounds from this plant. In addition, purported health benefits of the extracts and bioactive compounds derived from this plant were also addressed to support their potential as therapeutic agents.
16
Lowe, Henry, Blair Steele, Joseph Bryant, Ngeh Toyang, and Wilfred Ngwa. "Non-Cannabinoid Metabolites of Cannabis sativa L. with Therapeutic Potential." Plants 10, no. 2 (February 20, 2021): 400. http://dx.doi.org/10.3390/plants10020400.
Full textAbstract:
The cannabis plant (Cannabis sativa L.) produces an estimated 545 chemical compounds of different biogenetic classes. In addition to economic value, many of these phytochemicals have medicinal and physiological activity. The plant is most popularly known for its two most-prominent and most-studied secondary metabolites—Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD). Both Δ9-THC and CBD have a wide therapeutic window across many ailments and form part of a class of secondary metabolites called cannabinoids—of which approximately over 104 exist. This review will focus on non-cannabinoid metabolites of Cannabis sativa that also have therapeutic potential, some of which share medicinal properties similar to those of cannabinoids. The most notable of these non-cannabinoid phytochemicals are flavonoids and terpenes. We will also discuss future directions in cannabis research and development of cannabis-based pharmaceuticals. Caflanone, a flavonoid molecule with selective activity against the human viruses including the coronavirus OC43 (HCov-OC43) that is responsible for COVID-19, and certain cancers, is one of the most promising non-cannabinoid molecules that is being advanced into clinical trials. As validated by thousands of years of the use of cannabis for medicinal purposes, vast anecdotal evidence abounds on the medicinal benefits of the plant. These benefits are attributed to the many phytochemicals in this plant, including non-cannabinoids. The most promising non-cannabinoids with potential to alleviate global disease burdens are discussed.
17
Nugraha, Ari Satia, Bawon Triatmoko, Phurpa Wangchuk, and Paul A. Keller. "Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities." Biomolecules 10, no. 2 (January 24, 2020): 181. http://dx.doi.org/10.3390/biom10020181.
Full textAbstract:
This is an extensive review on epiphytic plants that have been used traditionally as medicines. It provides information on 185 epiphytes and their traditional medicinal uses, regions where Indigenous people use the plants, parts of the plants used as medicines and their preparation, and their reported phytochemical properties and pharmacological properties aligned with their traditional uses. These epiphytic medicinal plants are able to produce a range of secondary metabolites, including alkaloids, and a total of 842 phytochemicals have been identified to date. As many as 71 epiphytic medicinal plants were studied for their biological activities, showing promising pharmacological activities, including as anti-inflammatory, antimicrobial, and anticancer agents. There are several species that were not investigated for their activities and are worthy of exploration. These epipythes have the potential to furnish drug lead compounds, especially for treating cancers, and thus warrant indepth investigations.
18
Nyakudya, Trevor T., Thulani Tshabalala, Rachael Dangarembizi, Kennedy H. Erlwanger, and Ashwell R. Ndhlala. "The Potential Therapeutic Value of Medicinal Plants in the Management of Metabolic Disorders." Molecules 25, no. 11 (June 9, 2020): 2669. http://dx.doi.org/10.3390/molecules25112669.
Full textAbstract:
Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence of MetS has been attributed to genetic, epigenetic, and environmental factors. The adoption of sedentary lifestyles that are characterized by low physical activity and the consumption of high-energy diets contributes to MetS development. Current management criteria for MetS risk factors involve changes in lifestyle and the use of pharmacological agents that target specific biochemical pathways involved in the metabolism of nutrients. Pharmaceutical drugs are usually expensive and are associated with several undesirable side effects. Alternative management strategies of MetS risk factors involve the use of medicinal plants that are considered to have multiple therapeutic targets and are easily accessible. Medicinal plants contain several different biologically active compounds that provide health benefits. The impact of phytochemicals present in local medicinal plants on sustainable health and well-being of individuals has been studied for many years and found to involve a plethora of complex biochemical, metabolic, and physiological mechanisms. While some of these phytochemicals are the basis of mainstream prescribed drugs (e.g., metformin, reserpine, quinine, and salicin), there is a need to identify more medicinal plants that can be used for the management of components of MetS and to describe their possible mechanisms of action. In this review, we assess the potential health benefits of South African ethnomedicinal plants in protecting against the development of health outcomes associated with MetS. We aim to provide the state of the current knowledge on the use of medicinal plants and their therapeutically important phytochemicals by discussing the current trends, with critical examples from recent primary references of how medicinal plants are being used in South African rural and urban communities.
19
Srivastva, Mansi, Gargi Singh, Laxmi Parwani, and Jaspreet Singh. "Phytochemical composition of different plant parts of Acacia nilotica (L.) and their medicinal values." Research Journal of Chemistry and Environment 25, no. 7 (June 25, 2021): 183–90. http://dx.doi.org/10.25303/257rjce18321.
Full textAbstract:
Plant-derived medicines are long being used for the prevention and treatment of various human ailments. For the last few decades, plants are widely being explored for their active ingredients due to their immense potential in the treatment of critical illnesses. Thus, in recent years, exponential growth can be seen in the field of herbal medicines. Medicinal plants are a unique source of valuable phytochemicals. Their use in different medicine systems is gradually increasing due to their cost-effectiveness, easy availability and natural origin with fewer or no side effects. Acacia nilotica (L.) is a member of the family Fabaceae, commonly found in tropical and sub-tropical regions and the plant is widely known for its enormous medicinal values. Every plant part of A. nilotica is a source of many bioactive important secondary metabolites that are widely useful for the cure of various human diseases and the development of new drugs. An exhaustive literature survey revealed that tannins, flavonoids, alkaloids, polyphenols, fatty acids and carbohydrates are present as major classes of phytochemicals in different plant parts of A. nilotica. These phytochemicals exhibit significant antioxidant, anti-inflammatory, antibacterial, antifungal, antidiarrheal, antihypertensive, antispasmodic, anthelmintic, antiplatelet aggregation, anticancer and antiviral activities. The present review is aimed to organize the comprehensive information available on phytochemical composition and medicinal properties of different plant parts of A. nilotica viz. leaves, bark, flowers, seeds, pods, gum and roots. The study is useful to explore the therapeutic potential of different plant parts of A. nilotica which will further help in the development of new promising, safe, cost-effective drugs with a high therapeutic index from the different parts of the Acacia plant.
20
Ahmad, Mohammad, Anuradha Mishra, Afreen Usmani, and Md Parwez Ahmad. "Dietary Agents and Phytochemicals in the Prevention and Treatment of Hepatocellular Carcinoma: Review Article." Med Phoenix 2, no. 1 (October 13, 2017): 52–62. http://dx.doi.org/10.3126/medphoenix.v2i1.18388.
Full textAbstract:
Amongst all types of primary liver cancers, hepatocellular carcinoma (HCC) is the commonest form of liver cancer in the world. Cancer chemoprevention using dietary supplements and phytochemicals has attracted increasing attention in recent years. Numerous study reports suggest the role of phytochemicals and dietary compounds in the prevention and treatment of liver cancer. Certain dietary agents and related phytochemicals present in grapes, pomegranate, vegetables, beans, turmeric, soy, rice bran, and fish oils are reported to have chemopreventive potentials against hepatocellular carcinoma. Phytochemicals such as Carotenoids, Epigallocatechin gallate (EGCG), Curcumin, Resveratrol, Rutoside, Quercetin, Chrysin and Silibinin have possible therapeutic importance in tumor suppression during the initial phases of carcinogenesis. Many phytochemicals which are still under investigation lack the scientific data in support of anticancer properties of these compounds rather than anti-oxidant mechanism. So, emphasis should be given on the investigation of plausible molecular mechanism behind anticancer activity. This review summarizes the use of these dietary agents and phytochemicals in the treatment and prevention of HCC and also highlights the mechanisms responsible for their effects.Med Phoenix Vol.2(1) July 2017, 52-62
21
Achibat, Hanane, Nohad A. AlOmari, Federica Messina, Luca Sancineto, Mostafa Khouili, and Claudio Santi. "Organoselenium Compounds as Phytochemicals from the Natural Kingdom." Natural Product Communications 10, no. 11 (November 2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001119.
Full textAbstract:
Selenium is naturally present in soils but it is also produced by pollution from human activities into the environment. Its incorporation into plants affords organoselenium metabolites that, depending on the nature of the molecules and the plant species, can be incorporated into proteins, stored or eliminated by volatilization. The possibility to use the selenium metabolism of some plants as a method for bioremediation and, at the main time, as a source of selenated phytochemicals is here discussed taking into consideration the growing interest in organic selenium derivatives as new potential therapeutic agents.
22
Mawa, Shukranul, Khairana Husain, and Ibrahim Jantan. "Ficus caricaL. (Moraceae): Phytochemistry, Traditional Uses and Biological Activities." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/974256.
Full textAbstract:
This paper describes the botanical features ofFicus caricaL. (Moraceae), its wide variety of chemical constituents, its use in traditional medicine as remedies for many health problems, and its biological activities. The plant has been used traditionally to treat various ailments such as gastric problems, inflammation, and cancer. Phytochemical studies on the leaves and fruits of the plant have shown that they are rich in phenolics, organic acids, and volatile compounds. However, there is little information on the phytochemicals present in the stem and root. Reports on the biological activities of the plant are mainly on its crude extracts which have been proven to possess many biological activities. Some of the most interesting therapeutic effects include anticancer, hepatoprotective, hypoglycemic, hypolipidemic, and antimicrobial activities. Thus, studies related to identification of the bioactive compounds and correlating them to their biological activities are very useful for further research to explore the potential ofF. caricaas a source of therapeutic agents.
23
Thakur, Shifali, Hemlata Kaurav, and Gitika Chaudhary. "A Review on Woodfordia fruticosa Kurz (Dhatki): Ayurvedic, Folk and Modern Uses." Journal of Drug Delivery and Therapeutics 11, no. 3 (May 15, 2021): 126–31. http://dx.doi.org/10.22270/jddt.v11i3.4839.
Full textAbstract:
Woodfordia fruticosa kurz is an herbal plant that belongs to the family Lythraceae. This plant is widely distributed throughout the tropical and subtropical regions of India, Sri Lanka, China, Malaysia, Indonesia, Japan and Pakistan. The plant possesses a long history of medicinal use. The flowers of Woodfordia fruticosa are recorded to possess potent therapeutic values. The various phytochemicals isolated from this plant are tannins, flavonoids, anthraquinone, glycosides and polyphenols. The extract of flowers and leaves are associated with useful therapeutic activities. These phytochemical compounds have many pharmacological properties such as antimicrobial, hepatoprotective, cardioprotective, antioxidant, antiulcer, immunomodulatory, antifertility and anti-tumor. These pharmacological activities of Woodfordia fruticosa plant are also mentioned in the literature of ayurveda, yunani and other traditional systems of medicine. This review is intended to provide brief information on the plant Woodfordia fruticosa on the basis of chemical constituents, folk usage, ayurvedic usage, modern usage and its biological activities.
Keywords: Woodfordia fruticosa, antimicrobial, Ayurvedic, flavonoids, Octacosanol
24
Shirsath, Nitin R., and Ajaygiri K. Goswami. "Natural Phytochemicals and Their Therapeutic Role in Management of Several Diseases: A Review." Current Traditional Medicine 6, no. 1 (January 8, 2020): 43–53. http://dx.doi.org/10.2174/2215083805666190807111817.
Full textAbstract:
Introduction: These days, a lot of people face some health-related problems in day to day life. The conventional synthetic medicine is not effective enough to cure them alone. The conventional therapy for the management of these health-related issues involves the use of hazardous synthetic chemicals and surgical diagnosis, which have lots of serious side effects. It is necessary to conduct research on herbal medicines, this is an alternative approach to avoid the side effects of synthetic medicines to achieve high effectiveness, low cost and improve patient compliance. Methods: The present survey is an analysis of some of the available data on the use of plants with their biological source, active phytochemicals constituents and a probable activity/ mechanism of action of several classes of drugs. This work also focused on highlighting the advantages of natural medicines for maximum utilization. Results: This article aims to increase awareness about natural medicine and help people find a suitable herbal medicine for the treatment of specific diseases. Conclusion: This article also exhibits the scope for further process in the development of new natural substance for the management of several diseases.
25
Alqaraleh, Moath, and Violet Kasabri. "The Antiglycation Effect of Monomethyl Branched Chained Fatty Acid and Phytochemical Compounds and their Synergistic Effect on Obesity Related Colorectal Cancer Cell Panel." Romanian Journal of Diabetes Nutrition and Metabolic Diseases 26, no. 4 (December 1, 2019): 361–69. http://dx.doi.org/10.2478/rjdnmd-2019-0039.
Full textAbstract:
Abstract Background and aims: monomethyl branched chain fatty acids (mmBCFA) and phytochemicals including: Hydroxycitric Acid, Chlorogenic Acid and Piperine have been considered as an interesting agent for researches due to their role in diabetes and cancer. The present study examines the antiglycation effect of mmBCFA and phytochemicals and investigate their Synergistic effect on different colorectal cancer cell lines. Methods: This study was carried out by using murine monocyte-macrophage cell line and Methylglyoxal (MGO) to enhance the glycation process, furthermore to examine the antiproliferative effect of both the mmBCFA and phytochemicals we use Sulforhodamine B (SRB) assay against obesity related-colorectal cancer cell line panel. Results: Both phytochemicals and mmBCFA have a higher antiglycation effect than Aminoguanidine (AMG) significantly, moreover, all of the phytochemicals and mmBCFA have antiproliferative against SW620, CACO2 and SW480, nevertheless none of these agents was equipotent to Cisplatin, furthermore, the synergetic effect observed only when we co-incubate Piperine with mmBCFA. Conclusions: phytochemicals such as Hydroxycitric Acid, Chlorogenic Acid and Piperine and mmBCFA could be used as treatment to prevents the accumulation of advanced glycation end-products (AGEs) in diabetes. Furthermore, the co-incubation between these compounds can inhibit cancer growth, as alternative therapeutic strategy against obesity related-colorectal cancer.
26
Han, Ah-Reum, Hyunyoung Kim, Donglan Piao, Chan-Hun Jung, and Eun Kyoung Seo. "Phytochemicals and Bioactivities of Zingiber cassumunar Roxb." Molecules 26, no. 8 (April 19, 2021): 2377. http://dx.doi.org/10.3390/molecules26082377.
Full textAbstract:
Zingiber cassumunar Roxb. (Zingiberaceae), is an important medicinal plant known as “Plai (Phlai)” in Thailand, “Bangle” in Indonesia, and “Bulei” in China. Traditionally, this plant has been used to treat inflammation, pain, and respiratory problems. The rhizomes are the primary part of the plant that has been used for medicinal purposes due to their constituents with therapeutic properties, including phenylbutenoids, curcuminoids, and essential oils. Since the 1970s, many studies have been conducted on the phytochemicals and bioactivities of Z. cassumunar to establish fundamental scientific evidence that supports its use in traditional medicine. The accumulated biological studies on the extracts, solvent fractions, and constituents of Z. cassumunar have described their diverse medicinal properties, including antioxidant, anti-inflammatory, anticancer, neuroprotective/neurotrophic, cosmeceutical, and antifungal/antimicrobial bioactivities. In this review, we summarize information on the phytochemicals of Z. cassumunar and the bioactivities of its extracts and constituents.
27
C., Ramya, Vishnu AS, and Nasila K. "A Review: Cyanthillium cinereum (L) H. Rob." International Journal of Research and Review 8, no. 9 (September 16, 2021): 99–101. http://dx.doi.org/10.52403/ijrr.20210914.
Full textAbstract:
Cyanthillium cinereum (L) H. Rob (family Asteraceae) is also known as Poovamkurunnila in Malayalam. It is commonly found as a weed throughout in India. Cyanthillium cinereum is an annual herb with hairy stem, up to 12-75 cm height. The leaves are simple, alternate, ovate-elliptic or acute, irregularly dentate or crenate-serrate and hairy. Cyanthillium cinereum is an annual herb, contains various phytochemicals like cardiac glycosides, phenols, flavonoids, steroids, tannins, saponins and phlobatannins etc. Due to the presence of these phytochemicals Cyanthillium cinereum exhibits various activities like analgesic, antibacterial, antioxidant, anticancer, antispasmodic, antimalarial and antifungal etc. Keywords: Cyanthillium cinereum (L) H. Rob, Pharmacological activities, Therapeutic use.
28
Dauda Muhammed, Yetunde H. Adebiyi, Bernard O. Odey, Rahmatallah A. Alawode, Abdullateef Lawal, Banke Mary Okunlola, Jonathan Ibrahim, and Eustace Bonghan Berinyuy. "Dennettia tripetala (Pepper Fruit), a review of its ethno-medicinal use, phyto-constituents, and biological properties." GSC Advanced Research and Reviews 6, no. 3 (March 30, 2021): 035–43. http://dx.doi.org/10.30574/gscarr.2021.6.3.0024.
Full textAbstract:
There has been tremendous growth in field of herbal medicine as therapeutic agents. Dennettia tripetala, is known to possess ethnomedicinal properties and has been used for centuries in the Ayurvedic system of medicine for the treatments of various diseases. The present review provides detailed description on the distribution, ethno-medicinal use, phyto-constituents, and biological properties of the plant that justifies its use as a potential therapeutic agent in management of different diseases. The phyto chemical composition of Dennettia tripetala include alkaloids, tannins, saponins, flavonoids, terpenoids, steroids and cardiac glycosides while it biological activities include antioxidant, antidiabetic, antibacterial, antihypertensive, anticonvulsant, antitrypanosomal, antimalarial, anti-inflammatory and cytotoxic properties among others. In conclusion, Dennettia tripetala contains various nutritional and phytochemicals compositions that make it valuable for pharmacological purposes.
29
Vasanthi,, H. R., N. ShriShriMal, and D. K. Das. "Retraction Notice: Phytochemicals from Plants to Combat Cardiovascular Disease." Current Medicinal Chemistry 19, no. 14 (April 24, 2012): 2242–51. http://dx.doi.org/10.2174/092986712800229078.
Full textAbstract:
For many decades, the use of synthetic chemicals as drugs has been effective in the treatment of most diseases. Moreover, from ancient to modern history, many traditional plant based medicines are playing an important role in health care. Phytochemicals are natural bioactive compounds found in vegetables, fruits, medicinal plants, aromatic plants, leaves, flowers and roots which act as a defense system to combat against diseases. The phytochemicals from natural products cover a diverse range of chemical entities such as polyphenols, flavonoids, steroidal saponins, organosulphur compounds and vitamins. A number of bioactive compounds generally obtained from terrestrial plants such as isoflavones, diosgenin, resveratrol, quercetin, catechin, sulforaphane, tocotrienols and carotenoids are proven to reduce the risk of cardiovascular diseases and aid in cardioprotection which is the leading cause of death globally. The cardioprotective effects of the various phytochemicals are perhaps due to their antioxidative, antihypercholesteroemic, antiangiogenic, anti-ischemic, inhibition of platelet aggregation and anti inflammatory activities that reduce the risk of cardiovascular disorders. The multi-faceted role of the phytochemicals is mediated by its structure-function relationship and can be considered as leads for cardiovascular drug design in future. This review summarizes the findings of recent studies on selected phytochemicals as prophylactic and therapeutic agents in cardioprotection.
30
Nagi, Ravleen. "Therapeutic Role of Phytochemicals in the Prevention of Oral Potentially Malignant Disorders and Oral Cancer – A Review." Journal of Evolution of Medical and Dental Sciences 10, no. 16 (April 19, 2021): 1156–65. http://dx.doi.org/10.14260/jemds/2021/246.
Full textAbstract:
BACKGROUND Medicinal plants and their extracts have been found to possess potent antiinflammatory, antioxidant and anti-cancer properties that slow down the cellular proliferation and malignant transformation rate of orally potential malignant disorders such as oral leukoplakia, oral submucous fibrosis and oral lichen planus. They are a potential source of antioxidants such as vitamin A, E, and C that neutralize the free radicals produced in various oral mucosal lesions thereby preventing the mucosal damage. They have been found to modulate cellular signalling pathways and, this activation influences the cellular defence mechanisms that protect the normal cells against reactive oxygen species or reactive metabolites and induces apoptotic death of cancerous cells, thus chemoprevention ensues to prevent, reverse or delay carcinogenesis. They have been studied to enhance tumour cell killing and inhibition of metastasis by increasing number of immunocompetent cells such as macrophages, cytotoxic T lymphocytes, natural killer cells and by recruitment of antibodies at the tumour site. Now a days, natural herbs or phytochemicals are gaining attention due to side effects and increased antimicrobial resistance that often occur with prolonged use of chemotherapeutic agents. Therapeutic effect of phytochemicals in oral PMDs is very promising as they prevent the progression of dysplasia from mild to severe. Literature has revealed significant reduction in burning sensation, difficulty in swallowing and speech, and pain associated with the oral mucosal lesion. However, more research should be conducted in future to establish their use as an adjunctive therapy in oral potentially malignant disorders. By this review, an attempt has been made to highlight therapeutic potential of diverse herbs such as aloe vera, tulsi, neem, curcumin, lycopene, green and black tea, peppermint etc. in the reduction of clinical symptoms of burning sensation and pain associated with the oral mucosal lesions, and discusses their indispensable role in prevention of oral cancer. KEY WORDS Antioxidants, Chemoprevention, Phytochemicals, Oral Cancer
31
Ayoub, Zeenat, Archana Mehta, and Siddhartha Kumar Mishra. "ETHNOPHARMACOLOGICAL REVIEW OF NATURAL PRODUCTS IN CANCER PREVENTION AND THERAPY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 6 (June 7, 2018): 32. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.24792.
Full textAbstract:
The World Health Organization reports that approximately 80% population from developing countries are facing complications from synthetic drugs used in maintaining their primary health-care needs. The chemotherapeutic strategies are very striking and have earned serious concern as potential means of controlling the incidence of this dreadful disease. However, the major problem in cancer is the long lasting toxicity of the well reputable chemical drugs. Since ancient times, medicinal plants have attracted enormous attention, to fight against various diseases with their broad-spectrum biological and therapeutic properties. Although plants, phytochemicals and their analogues have been confirmed to be safe and effective, having strong anticancer properties. A number of pharmaceutical agents with diverse chemical structures of natural origin from plants have been discovered as anticancer agents such as vincristine, vinblastine, podophyllotoxin, camptothecin, taxol, resveratrol, withaferin A, quercetin, and curcumin. Further modifications of these phytochemicals led to the development of numerous outstanding molecules such as drugs like topotecan, irinotecan, taxotere, etoposide, and teniposide. In this in-depth review, we meticulously investigated the selected medicinal plants for their anticancer properties. In particular, novel compounds from plants have beneficial effects on human health. Our observations suggest the preventive and therapeutic use of phytochemicals in managing various human malignancies.
32
Rivera-Mondragón, Andrés, Orlando O. Ortíz, Mahabir P. Gupta, and Catherina Caballero-George. "Pharmacognostic Evaluation of Ten Species of Medicinal Importance of Cecropia: Current Knowledge and Therapeutic Perspectives." Planta Medica 87, no. 10/11 (July 20, 2021): 764–79. http://dx.doi.org/10.1055/a-1495-9785.
Full textAbstract:
AbstractThis work covers a systematic review of literature about the genus Cecropia from 1978 to 2020, emphasizing the analysis of 10 of the most relevant species and their associated biological activities. Cecropia is a neotropical genus, which comprises about 61 native species in the American continent where it is known to be part of the traditional medicine of numerous countries. Secondary metabolites described for this genus showed an elevated structural and functional diversity, where polyphenols have been the most abundant. Based on this diversity, Cecropia phytochemicals represent an important source of potential therapeutic agents yet to be exploited. This review also highlights the effectiveness of combining chemometrics and ultra-performance liquid chromatography-tandem mass spectrometry as a novel approach to successfully single out Cecropia species phytochemicals. While the medicinal use of Cecropia species is officially recognized in National Pharmacopoeias and Formularies of several Latin American countries, it is important to recognize that these phytomedicines are complex mixtures requiring a thorough understanding of their chemical composition and their correlation with biological activities to guarantee their quality, safety, and efficacy.
33
Salehi, Bahare, Sevil Albayrak, Hubert Antolak, Dorota Kręgiel, Ewelina Pawlikowska, Mehdi Sharifi-Rad, Yadav Uprety, et al. "Aloe Genus Plants: From Farm to Food Applications and Phytopharmacotherapy." International Journal of Molecular Sciences 19, no. 9 (September 19, 2018): 2843. http://dx.doi.org/10.3390/ijms19092843.
Full textAbstract:
Aloe genus plants, distributed in Old World, are widely known and have been used for centuries as topical and oral therapeutic agents due to their health, beauty, medicinal, and skin care properties. Among the well-investigated Aloe species are A. arborescens, A. barbadensis, A. ferox, and A. vera. Today, they account among the most economically important medicinal plants and are commonly used in primary health treatment, where they play a pivotal role in the treatment of various types of diseases via the modulation of biochemical and molecular pathways, besides being a rich source of valuable phytochemicals. In the present review, we summarized the recent advances in botany, phytochemical composition, ethnobotanical uses, food preservation, and the preclinical and clinical efficacy of Aloe plants. These data will be helpful to provide future directions for the industrial and medicinal use of Aloe plants.
34
Li, Shiming, Alexander Gosslau, Klaus Lange, and Chi-Tang Ho. "Profiled tea extracts exemplifying the importance of characterizing food bioactives: opinion piece." Journal of Food Bioactives 5 (March 31, 2019): 1–5. http://dx.doi.org/10.31665/jfb.2019.5172.
Full textAbstract:
Natural products from food and herbs have been used as functional food and medicine for centuries, much earlier than any of the current single molecule drugs in the market. Historically, natural products are the dominant resources of current global pharmaceutical market. Examples include world’s most commonly used drugs such as aspirin, penicillin and taxol. In viewing the increasing attraction and exponentially growing need for functional foods and effective medicines, the potential for natural products to serve as safe and effective preventive and therapeutic agents is of much interest. However, the importance in the phytochemical characterization of plant origin and associated extracts containing multiple phytochemicals in research and product development in this field has been plagued by overwhelmingly focusing on their biological effects. More than often inconsistent and invalid biological results are provided without chemical component identification and validation. Hence it is vital to characterize and identify the ingredients in the plant extracts – food bioactives- that play critical roles in promoting health or having therapeutic effects. The combination of chemical identification and biological evaluation is the key to having valid and consistent results in elucidating health beneficial properties of a plant or its extracts and also a key to have a meaningful comparison among similar studies due to the use of the same standard. Herein, we use tea as examples demonstrating the importance of phytochemical profiling and associated bioactive property of functional foods.
35
Mohan, Nayana, V. Meera, J. Soja, and M. S. Latha. "in silico Docking Analysis of Small Molecule Inhibitors from Nyctanthes arbor-tristis against Nipah Virus Infection." Asian Journal of Organic & Medicinal Chemistry 4, no. 4 (2019): 244–47. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p235.
Full textAbstract:
Nipah virus is a highly pathogenic paramyxovirus belonging to the genus Henipavirus, classified as Biosafety Level 4 (BSL4) agents. The virus causes severe illness characterized by encephalitis or respiratory disease in human. The case-lethality rate of Nipah was reported to be 70 % in India, since year 2001. Despite the high pathogenicity of virus, no therapeutics are currently approved for use in human. But, ribavirin, favipiravir and human mono clonal antibody was found to reduce the intensity in early stage. Medicinal plants serve as a rich source of therapeutically active compounds. Nyctanthus arbortristis Linn or pavizhamalli (Harsinger) is traditionally known to have activity against Nipha virus. In this study, therapeutic activity of phytochemicals arbortristoside A and arbortristoside C present in pavizhamalli plant against Nipha virus target was investigated by computational docking simulation. Computational docking analysis was performed using Schrodinger Suite. The phytochemicals arbortristoside A and arbortristoside C show promising binding affinity with the target Nipah virus than the reference drugs. Results of the study could be advantageous to develop a new lead molecule against Nipah virus infection.
36
Yin, Shu-Yi, Wen-Chi Wei, Feng-Yin Jian, and Ning-Sun Yang. "Therapeutic Applications of Herbal Medicines for Cancer Patients." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–15. http://dx.doi.org/10.1155/2013/302426.
Full textAbstract:
Medicinal herbs and their derivative phytocompounds are being increasingly recognized as useful complementary treatments for cancer. A large volume of clinical studies have reported the beneficial effects of herbal medicines on the survival, immune modulation, and quality of life (QOL) of cancer patients, when these herbal medicines are used in combination with conventional therapeutics. Here, we briefly review some examples of clinical studies that investigated the use of herbal medicines for various cancers and the development of randomized controlled trials (RCTs) in this emerging research area. In addition, we also report recent studies on the biochemical and cellular mechanisms of herbal medicines in specific tumor microenvironments and the potential application of specific phytochemicals in cell-based cancer vaccine systems. This review should provide useful technological support for evidence-based application of herbal medicines in cancer therapy.
37
Abood, Steven, Steven Eichelbaum, Sushmita Mustafi, Maria-Luisa Veisaga, Luis A. López, and Manuel Barbieri. "Biomedical Properties and Origins of Sesquiterpene Lactones, with a Focus on Dehydroleucodine." Natural Product Communications 12, no. 6 (June 2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200638.
Full textAbstract:
Dehydroleucodine, a sesquiterpene lactone, belongs to the terpenoid class of secondary metabolites. Dehydroleucodine and other Artemisia-derived phytochemicals evolved numerous biodefenses that were first co-opted for human pharmacological use by traditional cultures in the Middle East, Asia, Europe and the Americas. Later, these phytochemicals were modified through the use of medicinal chemical techniques to increase their potency. All sesquiterpene lactones contain an α-methylene-γ-lactone group, which confers thiol reactivity, which is responsible, in part, for their therapeutic effects. A wide range of therapeutic uses of sequiterpene lactones has been found, including anti-adipogenic, cytoprotective, anti-microbial, anti-viral, anti-fungal, anti-malarial and, anti-migraine effects. Dehydroleucodine significantly inhibits differentiation of murine preadipocytes and also significantly decreases the accumulation of lipid content by a dramatic down regulation of adipogenic-specific transcriptional factors PPARγ and C-EBPα. Dehydroleucodine also inhibits secretion of matrix metalloprotease-2 (MMP-2), which is a known protease involved in migration and invasion of B16 cells. In addition to these anti-adipogenic and anti-cancer effects, dehydroleucodine effectively neutralizes several bacterial species, including Bacillus cereus, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Helicobacter pylori, methicillin resistant Staphylococcus aueus (MRSA) and S. epidermis (MRSE). The compound also inhibits the growth and secretion of several toxins of Pseudomonas aeruginosa, possesses gastro-protective qualities and possesses anti-parasitic properties against Trypanosoma cruzi, responsible for Chagas disease. Other sesquiterpene lactones, such as parthenolide, costunolide, and helanin, also possess significant therapeutic utility.
38
Reglero, Clara, and Guillermo Reglero. "Precision Nutrition and Cancer Relapse Prevention: A Systematic Literature Review." Nutrients 11, no. 11 (November 16, 2019): 2799. http://dx.doi.org/10.3390/nu11112799.
Full textAbstract:
Cancer mortality rates are undergoing a global downward trend; however, metastasis and relapse after surgery and adjuvant treatments still correlate with poor prognosis and represent the most significant challenges in the treatment of this disease. Advances in genomics, metabolomics, and proteomics are improving our understanding regarding cancer metabolic diversity, resulting in detailed classifications of tumors and raising the effectiveness of precision medicine. Likewise, the growing knowledge of interactions between nutrients and the expression of certain genes could lead to cancer therapies based on precision nutrition strategies. This review aims to identify the recent advances in the knowledge of the mechanistic role of bioactive phytochemicals in foodstuffs in tumor progression, metastasis, and chemo-resistance in order to assess their potential use in precision nutrition therapies targeting relapse in lung, breast, colon, and prostate cancer, and leukemia. A considerable number of bioactive phytochemicals in foodstuffs were identified in the literature with proven effects modulating tumor growth, progression, and metastasis. In addition, the use of foodstuffs in cancer, and specifically in relapse therapies, is being reinforced by the development of different formulations that significantly increase the therapeutic efficiency of these products. This can open the possibility for testing combinations of bioactive phytochemicals with cancer relapse treatments as a potential prevention strategy.
39
Osman Adam, Osman Adam, Ragaa Satti Mohmmed Abadi, and Saad Mohamed Hussein Ayoub. "Antioxidant activity, Total Phenolic and Flavonoid Contents and Cytotoxic activity of Euphorbia aegyptiaca." Journal of Drug Delivery and Therapeutics 10, no. 2 (March 15, 2020): 37–41. http://dx.doi.org/10.22270/jddt.v10i2.3911.
Full textAbstract:
Euphorbia aegyptiaca is a herbaceous plant traditionally used in Sudan for treatment of various diseases, and the study of this plant is still limited. The aim of the present study was to screen the phytochemicals and to assess the Antioxidant activity, total phenolic, flavonoid contents and cytotoxic activity of Euphorbia aegyptiaca. The plant material was extracted successively by Soxhlet apparatus using n-hexane, chloroform and methanol. The chemical constituents of the extracts were carried out using the standard procedures. The Folin- Ciocalteu and Aluminium chloride method was employed to calculate the total phenolic and flavonoid content, respectively. The antioxidant activity, was assessed by measuring the scavenging activity of the DPPH (2.2Di (4-tert-octylphenyl)-1-picryl-hydrazyl) and Propyl Gallate as standard antioxidants. While cytotoxic activities were screened using brine shrimp. Phytochemical screening studies revealed that flavonoids, tannins, coumarins, saponins, sterols, terpenes, anthraquinones and alkaloids were the main phytochemicals present in extracts of E. aegyptiaca. The methanol extract showed the highest level of total phenolic contents (173.49±2.427 mg GAE/g) and flavonoid content (239.53±7.90 mg QE/g), and the highest antioxidant activity 89% with least (IC50 0.0449µg/ml), and the no toxicity against brine shrimp (LD50 3423.156). Furthermore, no toxicity in all extracts was observed. The present study is the first evaluation regarding the characterization of E. aegyptiaca and its safety, and the results demonstrate its antioxidant potential and suggest its safe therapeutic use. The results suggest that methanol extract is a rich source of phytochemicals and exhibits highest amount of and total phenolic, flavonoid content and significant antioxidant activity and it has no cytotoxic activity. E. aegyptiaca plant can be regarded as a promising Source of naturally occurring potential antioxidants.
Keywords: Euphorbia aegyptiaca, Sudan, Antioxidant, Total phenolic, total flavonoid, Cytotoxicity.
40
Mariadoss, Arokia V. A., Ramachandran Vinyagam, Vinothkumar Rajamanickam, Vijayalakshmi Sankaran, Sathish Venkatesan, and Ernest David. "Pharmacological Aspects and Potential Use of Phloretin: A Systemic Review." Mini-Reviews in Medicinal Chemistry 19, no. 13 (August 21, 2019): 1060–67. http://dx.doi.org/10.2174/1389557519666190311154425.
Full textAbstract:
Over the past two decades, many researchers have concluded that a diet rich in polyphenolic compounds plays an important therapeutic role in reducing the risk of cancer, cardiovascular disease, inflammation, diabetes, and other degenerative diseases. Polyphenolic compounds have been reported to be involved in neutralization of reactive oxygen species and charged radicals, and have anticarcinogenic effects, hepatoprotective effects, low-glycaemic response, and other benefits. The benefits of fruits and vegetables may be partly attributable to polyphenolic compounds, which have antioxidant and free radical scavenging properties. Fruits such as apples contain a variety of phytochemicals, including (+)-catechin and (-)-epicatechin, phlorizin, phloretin quercetin, cyanidin-3-Ogalactoside, chlorogenic acid, and p-coumaric acid, all of which are strong antioxidants. Phloretin, a natural phenolic compound, is a dihydrochalcone, which is present in the apple. It exhibits a wide variety of activities such as antioxidative, anti-inflammatory, anti-microbial, anti-allergic, anticarcinogenic, anti-thrombotic, and hepatoprotective, besides being involved in the activation of apoptotic associated gene expression and signal transduction in molecular pathways. Despite a multitude of clinical studies, new efforts are needed in clinical research to determine the complete therapeutic potential of phloretin.
41
Suleiman, Mohamed Hammad Adam. "Ethnobotanical, Phytochemical, and Biological Study of Tamarix aphylla and Aerva javanica Medicinal Plants Growing in the Asir Region, Saudi Arabia." Tropical Conservation Science 12 (January 2019): 194008291986948. http://dx.doi.org/10.1177/1940082919869480.
Full textAbstract:
In this study, Tamarix aphylla and Aerva javanica, plants used in folkloric medicine in the Asir region of Saudi Arabia were studied ethnobotanically, chemically, and biologically to assess their medicinal uses, phytochemical constituents, and biological activities. Ethnobotanical data were collected using semistructured interviews and the use values were calculated. A total of 61 informants were interviewed and results indicated high-value uses (0.9 and 0.7) for the plants. Phytochemical investigation indicated that the plants contained most of the phytochemicals that were tested for. The antioxidant activity was examined by assaying total phenolic content, 1,1-Diphenyl-2-picrylhydrazyl (DPPH), and hydrogen peroxide (H2O2) radical scavenging activity. .The bark extract of T. aphylla showed the best antioxidant effect in total phenolic content, DPPH, and H2O2 assays (278.02 ± 0.16 mg GAE/100 g; The half-maximal inhibitory concentration (IC50): DPPH, 18.39 ± 0.62 μg/mL; H2O2, 252.94 ± 1.86 μg/mL), followed by extract of the A. javanica aerial parts (228.60 ± 2.09 mg GAE/100 g; IC50: DPPH, 28.54 ± 0.53 μg/mL; H2O2, 154.17 ± 0.78 μg/mL) compared with ascorbic acid (DPPH: 27.27 ± 0.11 μg/mL; H2O2: 164.9 ± 0.37 μg/mL). The disc diffusion method performed for antimicrobial activity revealed weak activities in T. aphylla and A. javanica extracts (100 μg/mL) against six human pathogens. It was concluded that these plants possess therapeutic potential in the treatment of 18 types of ailments, which are important phytochemical constituents and antioxidant activities that justify their therapeutic uses in traditional medicine. Thus, this study laid sufficient background for further pharmacological research on extracts of these plants.
42
Lacatusu, Ioana, Teodora Alexandra Iordache, Mirela Mihaila, Dan Eduard Mihaiescu, Anca Lucia Pop, and Nicoleta Badea. "Multifaced Role of Dual Herbal Principles Loaded-Lipid Nanocarriers in Providing High Therapeutic Efficacity." Pharmaceutics 13, no. 9 (September 18, 2021): 1511. http://dx.doi.org/10.3390/pharmaceutics13091511.
Full textAbstract:
Although many phytochemicals have been used in traditional medicine, there is a great need to refresh the health benefits and adjust the shortcomings of herbal medicine. In this research, two herbal principles (Diosgenin and Glycyrrhiza glabra extract) coopted in the Nanostructured Lipid Carriers have been developed for improving the most desirable properties of herbal medicine—antioxidant and anti-inflammatory actions. The contribution of phytochemicals, vegetable oils and of lipid matrices has been highlighted by comparative study of size, stability, entrapment efficiency, morphological characteristics, and thermal behavior. According to the in vitro MTS and RTCA results, the dual herbal-NLCs were no cytotoxic toward endothelial cells at concentrations between 25 and 100 µg/mL. A rapid release of Glycyrrhiza glabra and a motivated delay of Diosgenin was detected by the in vitro release experiments. Dual herbal-NLCs showed an elevated ability to annihilate long-life cationic radicals (ABTS•+) and short-life oxygenated radicals (an inhibition of 63.4% ABTS•+, while the ability to capture radical oxygen species reached 96%). The production of pro-inflammatory cytokines was significantly inhibited by the newly herbals-NLC (up to 97.9% inhibition of TNF-α and 62.5% for IL-6). The study may open a new pharmacotherapy horizon; it provides a comprehensive basis for the use of herbal-NLC in the treatment of inflammatory diseases.
43
Djova, Valdi Steve, Ascension Maximilienne Nyegue, and François-Xavier Etoa. "The anti-arthritic and anti-inflammatory activities of aqueous extract powder bark of Anthocleista schweinfurthii Gilg (Loganiaceae)." Journal of Drug Delivery and Therapeutics 8, no. 6-s (December 15, 2018): 174–81. http://dx.doi.org/10.22270/jddt.v8i6-s.2212.
Full textAbstract:
Aqueous extract bark of Anthocleista schweinfurthii (ASE) was investigated for anti-arthritic, anti-inflammatory activities and phytochemicals screening. Phytochemical screening was carried out according, to LC-MS procedures, the anti-inflammatory effect of ASE was evaluated in vitro inhibition of 15-lipoxygenase (15-LOX) enzyme and proteinase inhibiting action assays. The anti-arthritic activity was performed according to the Bovine Serum Albumin (BSA) test. The chemical composition of ASE showed that it was mainly composed of isocyanate, biphenyltriol, methoxyflavanone, soscoparin and glucopyroside. In the anti-inflammatory assays, ASE showed selective inhibition of 15-lipooxygenase with IC50 value of and moderate activity against the inhibition of proteinase action with IC50 value of L. Both the methods showed that the ASE posses good anti-inflammatory activity. ASE had strong in vitro anti-arthritic activity with IC50 of , the positive control Diclofenac had IC50 value of The result of this study justified the use of this plant in traditional Cameroonian medicine in the treatment of inflammation. ASE may offer a new source of potential therapeutic agents for the effective treatment of arthritis and inflammation.
Keywords: Anthocleista schweinfurthii, phytochemical screening, anti-arthritic activity, anti-inflammatory activity,
44
Lin, Shih-Chao, Xiang Zhang, Caitlin W. Lehman, Han-Chi Pan, Ya Wen, and Shiow-Yi Chen. "A Natural Botanical Product, Resveratrol, Effectively Suppresses Vesicular Stomatitis Virus Infection In Vitro." Plants 10, no. 6 (June 17, 2021): 1231. http://dx.doi.org/10.3390/plants10061231.
Full textAbstract:
Numerous natural phytochemicals such as resveratrol are acknowledged as potent botanical agents in regulating immune responses. However, it is less understood whether such immunomodulatory phytochemicals are appropriate for use as direct treatments in veterinary viral diseases. In the present study, we investigated the efficacy of resveratrol in suppressing vesicular stomatitis virus (VSV) infection. Outbreaks of VSV can cause massive economic loss in poultry and livestock husbandry farming, and VSV treatment is in need of therapeutic development. We utilized a recombinant VSV that expresses green fluorescent protein (GFP) to measure viral replication in cells treated with resveratrol. Our findings revealed that resveratrol treatment affords a protective effect, shown by increased viability and reduced viral replication, as indicated by a reduction in fluorescent signals. Additionally, we found that resveratrol inhibition of VSV infection occurs via suppression of the caspase cascade. Structural analysis also indicated that resveratrol potentially interacts with the active sites of caspase-3 and -7, facilitating antiviral activity. The potential effect of resveratrol on reducing VSV infection in vitro suggests that resveratrol should be further investigated as a potential veterinary therapeutic or prophylactic agent.
45
Giri, Tapan Kumar. "Breaking the Barrier of Cancer Through Liposome Loaded with Phytochemicals." Current Drug Delivery 16, no. 1 (November 27, 2018): 3–17. http://dx.doi.org/10.2174/1567201815666180918112139.
Full textAbstract:
Currently, the most important cause of death is cancer. To treat the cancer there are a number of drugs existing in the market but no drug is found to be completely safe and effective. The toxicity of the drugs is the key problem in the cancer chemotherapy. However, plants and plant derived bioactive molecule have proved safe and effective in the treatment of cancers. Phytochemicals that are found in fruits, vegetables, herbs, and plant extract have been usually used for treating cancer. It has been established that several herbal drug have a strong anticancer activity. However, their poor bioavailability, solubility, and stability have severely restricted their use. These problems can be overcome by incorporating the herbal drug in nanolipolomal vesicles. In last few decades, researcher have used herbal drug loaded nanoliposome for the treatment and management of a variety of cancers. Presently, a number of liposomal formulations are on the market for the treatment of cancer and many more are in pipe line. This review discusses about the tumor microenvironment, targeting mechanism of bioactive phytochemicals to the tumor tissue, background of nanoliposome, and the potential therapeutic applications of different bioactive phytochemicals loaded nanoliposome in cancer therapy.
46
Chaudhary, Ashun, Vivek S. Jaswal, Sonika Choudhary, Sonika, Ajay Sharma, Vikas Beniwal, Hardeep S. Tuli, and Sanjeev Sharma. "Ferulic Acid: A Promising Therapeutic Phytochemical and Recent Patents Advances." Recent Patents on Inflammation & Allergy Drug Discovery 13, no. 2 (December 4, 2019): 115–23. http://dx.doi.org/10.2174/1872213x13666190621125048.
Full textAbstract:
Background: Among the various phenolics metabolites, ferulic acid is considered as the promising mitigating, restorative and antioxidant agent. Ferulic acid is one of the most commonly found natural products in vegetables, for example, tomatoes, sweet corn, and in rice grain. Phytochemicals are utilized in the treatment of human ailments and these are derived from the dietary compounds. Objective: The present review widely argued the calming restorative capability of ferulic acid alongside the scientific evidences and its proposed mechanism for activity. Furthermore, we provided the main practical points for the use of ferulic acid in oxidative damages during various diseases. Additionally, the relevant patents on ferulic acid with various therapeutic potential has been discussed. Methods: One hundred and twenty references have been cited in the present review article. The cited references were found to be suitable and described the therapeutic application of ferulic acid thoroughly. Conclusion: Ferulic acids are known to contrarily down-manage an assortment of extracellular and intrcelullular molecular targets related to infection movement. Various patents on ferulic acid based moieties have been accounted for from 2018. The ferulic acids have a wide scope of impacts against different infections like malignant growth, diabetes, cardiovascular and neurodegenerative diseases. The current review deals with the antioxidant property of ferulic acid and the recent patent describes the role of ferulic acid against human diseases.
47
Blebea, Nicoleta Mirela, Laura Adriana Bucur, and Simona Negreș. "The cannabinoids – important therapeutic approach in the field of oncology." Romania Journal of Pharmaceutical Practice 57, no. 2 (June 30, 2021): 63–67. http://dx.doi.org/10.37897/rjphp.2021.2.1.
Full textAbstract:
Oncological diseases are the most common cause of death worldwide, it is estimated that 25% of the population will face the diagnosis of cancer during life. Phytochemicals such as cannabinoids (CBs) have been used in various branches of medicine for their properties, and the discovery of the anti-tumor, anti-emetic and anti-inflammatory effects of some of these substances has encouraged their use in oncology. Phytocannabinoids, cannabidiol (CBD) and Δ-9-tetra-hydrocannabinol (THC), have numerous anti-emetic, analgesic, orexigenic, anti-inflammatory / immunosuppressive pharmacodynamic effects. In recent years, studies have been aimed at evaluating their efficacy as antineoplastic agents. Much in vivo and in vitro research has demonstrated the efficacy of CBs on certain tumor cell lines, highlighting their potential role in the complementary treatment of cancer. This paper suggests that exploring the molecular mechanisms induced by CBs in cancer cells may contribute to the development of effective treatments in oncological diseases.
48
Allayie, Sartaj Ahmad, Mushtaq Ahmed Parray*, Bilal Ahmad Bhat, and S. Hemalatha. "Phytochemical evaluation of leaf extracts of Naringi crenulata (roxb.) Nicolson." International Journal of Bioassays 5, no. 11 (October 31, 2016): 5110. http://dx.doi.org/10.21746/ijbio.2016.11.0020.
Full textAbstract:
The use of traditional medicines holds a great promise as an easily available source as effective medicinal agents to cure a wide range of ailments among the people particularly in tropical developing countries like India. The present study investigates the qualitative and quantitative analysis of the major bioactive constituents of N. crenulata leaf extracts. The extractive values of aqueous, acetone and chloroform extracts were found to be 11.34, 4.24 and 6.06 respectively. Qualitative phytochemical analysis of these three solvent extracts confirm the presence of Alkaloids, Saponins, Flavonoids and Phenolic compounds in all the three extracts; however, these phytochemicals were more significant in aqueous extract. Quantitative analysis was carried out using TLC method by different solvent system. Amongst various solvent systems, Butanol: acetic acid: water (9: 0.9: 0.1 v/v/v) shows maximum resolution and number of spots produced at long UV (365 nm) and under iodine vapours. The TLC chromatograms constituted different coloured phytochemical compounds with different Rf values. It can be conveniently used to evaluate the quality of different area samples. This indicates that the leaves can be useful for treating different diseases because the therapeutic activity of a plant is due to the presence of particular class of compounds and thus can serve as potential sources of useful drugs in future.
49
Omara, Timothy, Ambrose K. Kiprop, and Viola J. Kosgei. "Intraspecific Variation of Phytochemicals, Antioxidant, and Antibacterial Activities of Different Solvent Extracts of Albizia coriaria Leaves from Some Agroecological Zones of Uganda." Evidence-Based Complementary and Alternative Medicine 2021 (June 15, 2021): 1–14. http://dx.doi.org/10.1155/2021/2335454.
Full textAbstract:
Albizia coriaria Welw ex. Oliver is a customary African medicinal plant, which has a long history of utilization in the management of oxidative stress-induced and bacterial diseases. However, there is no report on the phytochemicals, antioxidant, and antibacterial activities of its leaves. The aim of this study was therefore to compare the phytochemicals, antioxidant, and antibacterial potential of A. coriaria leaves from Jinja, Kole, and Mbarara districts of Uganda. Shade-dried leaf samples were ground into powder and successively extracted with ethyl acetate, ethanol, and distilled water. Phytochemical screening indicated the presence of alkaloids, phenols, saponins, flavonoids, cardiac glycosides, tannins, and terpenes as the major secondary metabolites in the extracts. Total phenolic and flavonoid contents and total in vitro antioxidant activity were found to be the highest for ethanolic extracts, with the highest contents (101.72 ± 0.22 mg GAE/g DW; 13.23 ± 0.03 mg QE/g DW) and antioxidant potential (IC50 = 18.65 ± 0.06 mg/mL) being for leaves from Mbarara district. Antibacterial activity of the extracts determined by agar disc diffusion method revealed that ethanolic extracts had higher antibacterial activities with mean zones of inhibition of 6.00 ± 1.73 to 10.00 ± 1.73 mm, 5.00 ± 1.00 to 12.30 ± 1.53 mm, 17.00 ± 0.00 to 25.00 ± 2.65 mm, and 9.00 ± 1.73 to 16.00 ± 1.73 mm for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi, respectively. Ethyl acetate extracts of A. coriaria leaves from Kole and Mbarara had lower antibacterial activities, while aqueous extracts and ethyl acetate extract of leaves from Jinja showed no antibacterial activity. The current study for the first time established that A. coriaria leaves possess therapeutic phytochemicals with significant in vitro antioxidant and antibacterial activities, which lend credence to their use in traditional management of oxidative stress-induced conditions and bacterial diseases in Uganda. Structural elucidation of the responsible pure compounds for the observed bioactivities as well as toxicity studies of the extracts is recommended.
50
Murthy, Hosakatte Niranjana, Guggalada Govardhana Yadav, Yaser Hassan Dewir, and Abdullah Ibrahim. "Phytochemicals and Biological Activity of Desert Date (Balanites aegyptiaca (L.) Delile)." Plants 10, no. 1 (December 25, 2020): 32. http://dx.doi.org/10.3390/plants10010032.
Full textAbstract:
Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. Balanites aegyptiaca (L.) Delile belongs to the Zygophyllaceae family and is popularly known as “desert date”, reflecting its edible fruits. This tree grows naturally in Africa, the Middle East and the Indian subcontinent. Local inhabitants use fruits, leaves, roots, stem and root bark of the species for the treatment of various ailments. Several research studies demonstrate that extracts and phytochemicals isolated from desert date display antioxidant, anticancer, antidiabetic, anti-inflammatory, antimicrobial, hepatoprotective and molluscicidal activities. Mesocarp of fruits, seeds, leaves, stem and root bark are rich sources of saponins. These tissues are also rich in phenolic acids, flavonoids, coumarins, alkaloids and polysterols. Some constituents show antioxidant, anticancer and antidiabetic properties. The objective of this review is to summarize studies on diverse bioactive compounds and the beneficial properties of B. aegyptiaca.