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Journal articles on the topic 'Phytoconstituents'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Hlatshwayo, Sphamandla, Nokukhanya Thembane, Suresh Babu Naidu Krishna, Nceba Gqaleni, and Mlungisi Ngcobo. "Extraction and Processing of Bioactive Phytoconstituents from Widely Used South African Medicinal Plants for the Preparation of Effective Traditional Herbal Medicine Products: A Narrative Review." Plants 14, no. 2 (2025): 206. https://doi.org/10.3390/plants14020206.

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Medicinal plants are sources of crude traditional herbal medicines that are utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due to their potent antioxidant and anti-inflammatory effects. It is estimated that about 80% of the population in developing countries rely on herbal traditional medicines for healthcare. This signifies the need for traditional herbal medicines, which are polyherbal formulations prepared by traditional health practitioners. This review examines preparatory steps to extract bioactive phytoconstituents and post-extraction p

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Ogbeide, Uyi, Eunice Oriotor, and Henry Okeri. "Molecular docking assessment of the tocolytic potential of phytoconstituents of five medicinal plants used against preterm labour." Journal of Science and Practice of Pharmacy 10, no. 1 (2023): 522–32. http://dx.doi.org/10.47227/jsppharm.v10i1.5.

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Introduction: Preterm labour is currently being treated with a number of medications with untoward side effects, but many medicinal plants have also been found useful. This study aims to assess the tocolytic potentials of the phytoconstituents of Barteria fistulosa, Ficus capensis, Ficus exasperate, Newbouldia laevis and Zingiber officinale. Methods: Phytoconstituents present in these plants were obtained from literature sources, their 3D SDF structures were obtained from PubChem; the protein Beta-2 adrenergic receptor (7DHI) was processed using Chimera and molecular docking was done using PyR

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Sudhanshu Kumar Jha, Chandan Kumar, Soumya Bharadwaj, et al. "Synthesis, in-silico design and spectral characterization, elucidation of Cannabis sativa L. cannabaceae containing phytoconstitutents demonstrating novel therapeutic efficacy against epilepsy." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 1280–93. http://dx.doi.org/10.30574/wjarr.2023.18.2.0968.

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Cannabis sativa L. is a significant herbaceous species native to Central Asia that has been utilised for folk medicine and other industrial applications. It is a rich source of cellulosic and woody fibres as well as a treasure trove of phytochemicals. The pharmaceutical and construction industries are both very interested in this plant since its metabolites have powerful bioactivities on humans. Cannabinoids are the most researched class of chemicals, primarily because of the vast range of pharmacological effects they have on humans, including psychoactive effects. The phytoconstituents Apigen

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Danao, Kishor, Shruti Kale, Vijayshri Rokde та ін. "In Silico Prediction of Antidiabetic Activity of Phytoconstituents of Pterocarpus Marsupium Targeting α-Amylase Enzyme". Biosciences Biotechnology Research Asia 20, № 1 (2023): 147–62. http://dx.doi.org/10.13005/bbra/3077.

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ABSTRACT: Background Diabetes is characterized by a metabolic imbalance of blood sugar levels. α-amylase enzyme hydrolyzed starch into glucose units. Current therapy has significant side effects. Current investigation of in silico antidiabetic evaluation of phytoconstituents of Pterocarpus marsupium targeting α-amylase. Methods In silico studies were investigated to determine the binding affinity of phytoconstituents of Pterocarpus marsupium in additional with the crystal structure of α-amylase (PDB ID: 3BC9) with help of Pyrx in autodock vina software. Further, investigate the amino acid inte

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Pratham, S. Shinde* Jeeshan J. Shaikh Yash N. Sharma Poonam R. Shewale Chaitanya S. Shisode. "Extraction, Standardization And Evaluation Of Gallic Acid Obtained From Peels And Stems Of Musa acuminata." International Journal of Pharmaceutical Sciences 2, no. 7 (2024): 562–68. https://doi.org/10.5281/zenodo.12699589.

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Musa acuminata commonly known as banana plant is a storehouse of various phytoconstituents and one such constituent is gallic acid. Gallic acid is believed to have antibacterial property and hence can be used as an alternative to antibiotics and in case of antibiotic resistance. This article is an attempt to provide for an alternative method for extraction of gallic acid and evaluating it for desired phytoconstituents. The process of extraction begins with collecting the plant materials for extraction that is in our case peels and stem of banana plant. These plant materials need to be dried be

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G., M. Srimyvizhiy1* K. B. Ilango2 T. Geetha3 S. Jayashree3 S. Kaviyanchally3 M. Mutharasi3 A. Naveenkumar3 K. Nithishkumar3 M. Pooja3 S. Periasamy3. "A Review On Analytical Method Development And Validation For Broccoli." International Journal in Pharmaceutical Sciences 2, no. 10 (2024): 1662–67. https://doi.org/10.5281/zenodo.14000869.

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A simple accurate and selective methods are developed and validation for determination of phytoconstituents in broccoli by products. Broccoli is a fresh green vegetable in the cabbage family and it contains main phytoconstituent is sulforaphane which is found in isothiocyanate group of organosulfur compounds. The sulforaphane is mainly used to prevent cancer. In this review, the methods were developed and it also includes validation parameters for the determination of phytoconstituents in broccoli. Results are consistent with expected ranges. The broccoli UV range results in three bands UVA 31

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Thani, Parbat Raj, Joel B. Johnson, Surya Bhattarai, et al. "Profiling Key Phytoconstituents in Screw-Pressed Nigella Solid Residue and Their Distribution in Products and Byproducts During Oil Processing." Applied Sciences 15, no. 2 (2025): 986. https://doi.org/10.3390/app15020986.

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Nigella sativa L. (generally known as black cumin) is a medicinal plant prized for its therapeutic and nutritional benefits. Its seed oil is used extensively in pharmaceuticals, nutraceuticals, cosmetics, and cooking. However, extracting oil to satisfy the world’s needs leaves behind plenty of solid residues. The seeds of Nigella are loaded with health-benefiting phytoconstituents, but so might their extraction residues. While much research on seeds and oil has been carried out, there is relatively little information about solid residue, particularly regarding health-benefiting phytoconstituen

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Sudhanshu, Kumar Jha, Kumar Chandan, Bharadwaj Soumya, et al. "Synthesis, in-silico design and spectral characterization, elucidation of Cannabis sativa L. cannabaceae containing phytoconstitutents demonstrating novel therapeutic efficacy against epilepsy." World Journal of Advanced Research and Reviews 18, no. 2 (2023): 1280–93. https://doi.org/10.5281/zenodo.8414284.

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<em>Cannabis sativa L.</em> is a significant herbaceous species native to Central Asia that has been utilised for folk medicine and other industrial applications. It is a rich source of cellulosic and woody fibres as well as a treasure trove of phytochemicals. The pharmaceutical and construction industries are both very interested in this plant since its metabolites have powerful bioactivities on humans. <em>Cannabinoids</em> are the most researched class of chemicals, primarily because of the vast range of pharmacological effects they have on humans, including psychoactive effe

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Banpure, Sonali G., Vitthal V. Chopade, Pravin D. Chaudhari, and Pramod L. Ingale. "Anti-Alzhimer Activity of Bay Leaves in Scopolamine-induced Rat Model." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 01 (2023): 17–22. http://dx.doi.org/10.25258/ijddt.13.1.3.

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Indian spices always play a great role in Ayurveda and Indian medicine. So, analyzing these plants for their unknown and specialized activity is great. Nearly all the spices have some activity on the brain and CNS. Bay leaves are one of the most common culinary spices from day to day life of Indians. In this study, we have studied bay leaves for their anti-Alzheimer activity which depends on the inhibition of acetylcholine esterase and butyrylcholinesterase. For this study, fi rstly bay leaf oil was extracted by hydrodistillation. Further phytoconstituent like alpha-pinene, terpineol, 1,8-cine

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Mehlawat, Nisha, Deepak Chand Sharma, Ravi Datta Sharma, and Jinny Toma. "A Computational Study to Detect the Potential of Phytoconstituents for Drug Development Against Urinary Tract Infection." Biosciences Biotechnology Research Asia 22, no. 2 (2025): 687–97. https://doi.org/10.13005/bbra/3394.

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ABSTRACT: Urinary tract infection are global health problem. Antibiotic resistance is a major concern in the treatment of UTI. So, there is necessity for prevention and cure of UTI by alternative therapy. Medicinal plants extracts are used for many ailments. In our study we selected some phytoconstituents from plants which has shown anti uropathogenic activity invitro to detect their potentiality for drug development with computational tools SwissADME and DruMAP along with some existing drugs. We also included potential compound named sunitinib that shows antiviral and anticancer property as d

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Martínez-Lobos, Manuel, Estela Tapia-Venegas, Paula Celis-Plá, et al. "Effect of Industrial Pollution in Puchuncaví Valley on the Medicinal Properties of Senecio fistulosus Poepp. ex Les (Asteraceae): Content of Phytoconstituents and Their Antioxidant and Cytotoxic Activities." Molecules 28, no. 20 (2023): 7038. http://dx.doi.org/10.3390/molecules28207038.

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Senecio fistulosus, an endemic plant in Chile, is highly regarded for its medicinal properties and is popular in alternative medicine. It thrives even in polluted areas, like Puchuncaví Valley, Chile. Therefore, the study aimed to assess the impact of industrial pollution in Puchuncaví Valley, Chile, on the phytoconstituent content, as well as the antioxidant and cytotoxic activities, of S. fistulosus. Phenols, flavonoids, and anthraquinones content were measured, alongside the assessment of antioxidant activities. Additionally, a GC-MS analysis was conducted to profile the phytoconstituents,

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Sood, Shreya, Sushma Devi, Thakur Gurjeet Singh, Amarjot Kaur, Vinita Singh, and Prinsi Sahpuriya. "Phytoconstituents in Breast Cancer Prevention." Journal of Pharmaceutical Technology, Research and Management 10, no. 1 (2022): 37–45. http://dx.doi.org/10.15415/jptrm.2022.101005.

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Background: In today’s developing nations, breast cancer (BC) is among the foremost risk factor for women. The causes of mortality are still unclear, yet they are frequently related to socioeconomic level and way of life. Numerous clinical therapies have been employed up to this point, i.e., radiotherapy, hormonal treatment, targeted treatment, mastectomy, and treatment with drugs etc. Purpose: However, resistance development to chemotherapeutic drugs, radiation and hormonal therapy is one of the common problems for many of the patients with BC. Numerous studies have looked at the anti-cancer

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PRİYA, Shiva, Mehak TYAGI, Devadharshini DHANDAYUTHAPANI, and Jayaram SARAVANAN. "UNVEILING THE THERAPEUTIC POTENTIAL OF GINKGO BILOBA: A NETWORK PHARMACOLOGY APPROACH FOR PARKINSON’S DISEASE." Ankara Universitesi Eczacilik Fakultesi Dergisi 48, no. 1 (2023): 9. http://dx.doi.org/10.33483/jfpau.1340094.

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Objective: The aim of the current study is to identify the major phytoconstituents in Ginkgo biloba that could modulate the role of major therapeutic targets involved in the pathogenesis of Parkinson’s disease using approaches in network pharmacology. Material and Method: The phytoconstituents in Ginkgo biloba and their therapeutic targets and the targets of Parkinson’s disease were identified using various online databases and software. The identified phytoconstituents were subjected to evaluation of several pharmacokinetic properties and druglikeness study. The phytoconstituents with favoura

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Shewale, Sunil, Vaishali Ravindra Undale, Maruti Shelar, et al. "Preliminary Pharmacognostic, Physicochemical and Phytochemical Evaluation of Plumeria Obtuse Seed Pods." Defence Life Science Journal 8, no. 1 (2023): 29–40. http://dx.doi.org/10.14429/dlsj.8.18172.

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Plumeria obtuse L. (Apocynaceae) is an ornate outdoor plant. The plant was traditionally used during accidentalinjuries. However, the pharmacognosy of this plant is very poorly explored. Therefore, we have conducted this study to assess the distinctive qualities of the P. obtusa. To investigate P. obtusa seed pods’ preliminary pharmacognostic, physical-chemical, phytochemical, microscopic, and phytoconstituent potential. Initially, the shape and microscopic characteristics of plant seed pods were assessed. Physicochemical analysis was used for the standardization. Utilizing several chemical te

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Rana, Lalit, Ranjit Kumar Harwansh, and Rohitas Deshmukh. "Recent Updates on Phytopharmaceuticals-Based Novel Phytosomal Systems and Their Clinical Trial Status: A Translational Perspective." Critical Reviews™ in Therapeutic Drug Carrier Systems 42, no. 1 (2025): 1–54. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v42.i1.10.

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Phytopharmaceuticals are the newly termed herbal medicine, which includes standardized extract, bioactive fraction, and phytoconstituent. They have been practiced to cure, treat, and mitigate diseases. Phytopharmaceuticals have many health benefits, but their therapeutic efficacy is limited due to poor absorption, low bioavailability, and early elimination profile. A novel phospholipid complex is a newly introduced patented technology developed to incorporate the standardized plant extracts/fractions or water-soluble phytoconstituents into phospholipids to produce lipid compatible molecular co

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Jain, Nem Kumar, Balakumar Chandrasekaran, Nasha’t Khazaleh, et al. "Computational Network Pharmacology, Molecular Docking, and Molecular Dynamics to Decipher Natural Compounds of Alchornea laxiflora for Liver Cancer Chemotherapy." Pharmaceuticals 18, no. 4 (2025): 508. https://doi.org/10.3390/ph18040508.

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Background: Alchornea laxiflora (Benth.) Pax & K. Hoffm. (A. laxiflora) is utilized as a traditional herb for treating several diseases. Objective: Our study aims to identify the active phytochemical candidates from A. laxiflora and analyses to predict their anticancer activity mechanism by employing network pharmacology, molecular docking, and molecular dynamics (MD). Methods: The phytoconstituents of A. laxiflora were retrieved from the literature, and phytoconstituent-related targets implicated in hepatocellular carcinoma (HCC) were collected from respective databases. Computational met

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Sharma, Tinky, Binjita Pandey, Bishnu Kumar Shrestha, Gayatri Maiya Koju, Rojeena Thusa, and Nabin Karki. "Phytochemical Screening of Medicinal Plants and Study of the Effect of Phytoconstituents in Seed Germination." Tribhuvan University Journal 35, no. 2 (2020): 1–11. http://dx.doi.org/10.3126/tuj.v35i2.36183.

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Phytochemical screening of ten different locally available plant parts was done in methanol extract. Tannin, quinine, terpenoid, flavonoid, steroid, alkaloid, cardiac glycoside, glycoside, volatile oils, etc were the phytoconstituents found in plants. The study of the effect of phytoconstituents in the germination of Pisum sativum seeds revealed that the phytoconstituents present in plant extracts showed the cytotoxic effect in living cells i.e. in germinating Pisum sativum seeds. The phytoconstituents present in the plant extract showed an effect on cell proliferation and growth. Hence these

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Anand, Abhinav, Neha Sharma, and Navneet Khurana. "PREDICTION OF ACTIVITY SPECTRA OF SUBSTANCES ASSISTED PREDICTION OF BIOLOGICAL ACTIVITY SPECTRA OF POTENTIAL ANTI-ALZHEIMER’S PHYTOCONSTITUENTS." Asian Journal of Pharmaceutical and Clinical Research 10, no. 16 (2017): 13. http://dx.doi.org/10.22159/ajpcr.2017.v10s4.21330.

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Objective: To predict the biological activity of certain phytoconstituents for their anti-AD effects.Methods: Several phytoconstituents were selected on the basis of reported literature. The anti-AD activities of selected phytoconstituents were predicted by employing canonical simplified molecular-input line-entry system obtained from PubChem using PASS online.Results: Several phytoconstituents were predicted to have effects better than marketed drugs under some or the other out of the chosen six areas of pharmacological intervention. On the other hand, several new avenues were predicted in wh

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I. Namirah, Fadilah, S. Dewi, F. V. I. de Lima, and N. S. Hardiany. "SENOLYTIC ACTIVITY EVALUATION OF CORIANDER (Coriandrum sativum L) PHYTOCONSTITUENTS: In-silico STUDY." RASAYAN Journal of Chemistry 15, no. 04 (2022): 2584–90. http://dx.doi.org/10.31788/rjc.2022.1547007.

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Coriander phytoconstituent has pro-apoptotic and anti-inflammatory activities. This study evaluated the activity of Coriander phytoconstituent against the Senescent Cell Anti-Apoptotic Pathways (SCAPs) network nodes that serve as targets for senolytic drugs. Docking simulations were performed using Autodock Vina PyRx (v0.8), Autodock Tools 1.5.6, and visualized by the Discovery Studio Visualizer. The anti-apoptotic protein (BCL-XL, BCL-2, BCLW, and survivin) interaction network was obtained from String db.org. The flavonoid compounds showed good binding energy than non-flavonoid compounds. In

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Ng, Phui Qi, Laura Soon Cheau Ling, Jestin Chellian, et al. "Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents." Current Pharmaceutical Design 26, no. 36 (2020): 4580–90. http://dx.doi.org/10.2174/1381612826666200610111013.

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Many plant-based bioactive compounds have been serving as the origin of drugs since long ago and many of them have been proven to have medicinal value against various chronic diseases, including, cancer, arthritis, hepatic diseases, type-2 diabetes and cardiovascular diseases. However, their clinical applications have been limited due to their poor water solubility, stability, low bioavailability and extensive transformation due to the first-pass metabolism. The applications of nanocarriers have been proven to be able to improve the delivery of bioactive phytoconstituents, resulting in the enh

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Pandey, Binjita, Tinky Sharma, Bishnu Kumar Shrestha, et al. "Screening of Phytoconstituents in Medicinal Plants and Study of Their Effect in Seed Germination." Amrit Journal 3, no. 1 (2023): 57–65. http://dx.doi.org/10.3126/amritj.v3i1.61542.

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Due to the existence of bioactive phytochemicals in plants, they have been traditionally utilized as medicine for a very long time. The present study was aimed to determine the phytoconstituents present in ten different plants collected from Katunje-Bhaktapur, Nepal. The methanol extract of the sample was used for analyzing the phytoconstituents present in the plant sample. The result revealed the existence of several phytoconstituents like alkaloid terpenoid, quinine, tannin, saponin and flavonoid in these plants. Similarly, the impact of phytoconstituents on germination of Pisum sativum seed

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Hussain, Mohammad Musarraf. "A Comprehensive Review on the Phytoconstituents from Six Species of the Genus Amaranthus." Bangladesh Pharmaceutical Journal 22, no. 1 (2019): 117–24. http://dx.doi.org/10.3329/bpj.v22i1.40083.

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The objective of this review is to consider the phytoconstituents from six species under the genus Amaranthus (A. retroflexus, A. spinosus, A. viridis, A. caudatus, A. hypocondriacus and A. tricolor). A total of sixty five (1-65) phytoconstituents with chemical structures have been reported in this study. A. retroflexus consists of high number of reported phytoconstituents. Bangladesh Pharmaceutical Journal 22(1): 117-124, 2019

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Gaikwad, Abhijeet Ramnath, Komal D. Ahire, Aachal A. Gosavi, K. S. Salunkhe, and Aditi Khalkar. "Gaikwad Abhijeet R. Phytosome as a Novel Drug Delivery System for Bioavailability Enhancement of Phytoconstituents and its Applications: A Review." Journal of Drug Delivery and Therapeutics 11, no. 3 (2021): 138–52. http://dx.doi.org/10.22270/jddt.v11i3.4847.

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Phytoconstituents are used extensively in modern science due to their varied therapeutic actions with few side effects. Regardless of their excellent pharmacodynamic activity, many Phytoconstituents have shown less bioavailability in vivo. Novel drug delivery systems have gained vital importance due to their increased bioavailability, and overall therapeutics. The water miscible Phytoconstituents have excellent bioactivity in vitro, however poor or no action in vivo. Phytosome technology can overcome this drawback during which the Phyto actives are allowed to react with phospholipid molecules.

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Rasheed, Shebina P., Aiswarya Aiswarya PJ, Aleena Basheer, et al. "Emergence of Anti-HIV Phytoconstituents." Asian Journal of Pharmaceutical and Health Sciences 11, no. 3 (2021): 2549–55. http://dx.doi.org/10.5530/ajphs.2021.11.23.

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Galla, Rajitha, Vidya Rani Murthi, Yasmintaj Shaik, Saritha Karnati, Umakanth Naik Vankadoth, and Umamaheswari Amineni. "Computational Investigation of Bioactive Phytoconstituents as SarS-Cov-2 Main Protease Inhibitors Through Molecular Docking and Interaction Fingerprint Studies." Biomedical and Pharmacology Journal 17, no. 2 (2024): 863–80. http://dx.doi.org/10.13005/bpj/2908.

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Since 2019, the SARS-CoV-2 infection has continued to cause significant human suffering. Numerous investigations into the viral pathogenesis have led to converging conclusions on how the virus enters and spreads within the host. The main protease (Mpro) of coronaviruses has been considered as an attractive therapeutic target because of its important role in processing polyproteins translated from viral RNA. Many studies discovered that phytoconstituents possess potent antiviral activities. Hence, in the present work, 439 co-crystal ligands of SARS-CoV-2 Mpro were collected and docked with Mpro

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Peeriga, Raveesha, S. A. Mohamed Shiek Arabath, Krishnaveni Manubolu, Bency Baby Thelappilly, and Lakshmi Chakradhar Yarlagadda. "Insilico Assessment of Phytoconstituents in Myxopyrum Smilacifolium Blume against Arthritis." Biomedical and Pharmacology Journal 17, no. 1 (2024): 235–41. http://dx.doi.org/10.13005/bpj/2851.

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Myxopyrum smilacifolium Blume geographical occurrence is southern part of India and its usage for the treatment of various diseases has been marked in Traditional Medicine. The present study was aimed to examine the phytoconstituents in Myxopyrum smilacifolium Blume for antiarthritic activity by insilico approach. Antiarthritic activity of phytoconstituents in Myxopyrum smilacifolium Blume was performed by using software Autodock 4.0. For each phytoconstituents the pharmacokinetic parameters are also assessed by online tools. The study revealed that phytocompounds, Arenarioside, Verbascoside a

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Salaria, Deeksha, Rajan Rolta, Jyoti Mehta, et al. "Phytoconstituents of traditional Himalayan Herbs as potential inhibitors of Human Papillomavirus (HPV-18) for cervical cancer treatment: An In silico Approach." PLOS ONE 17, no. 3 (2022): e0265420. http://dx.doi.org/10.1371/journal.pone.0265420.

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Human papillomavirus (HPV) induced cervical cancer is becoming a major cause of mortality in women. The present research aimed to identify the natural inhibitors of HPV-18 E1 protein (1R9W) from Himalayan herbs with lesser toxicity and higher potency. In this study, one hundred nineteen phytoconstituents of twenty important traditional medicinal plants of Northwest Himalayas were selected for molecular docking with the target protein 1R9W of HPV-18 E1 Molecular docking was performed by AutoDock vina software. ADME/T screening of the bioactive phytoconstituents was done by SwissADME, admetSAR,

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Joy, Anit Treesa, Harish M, and Rishad K. S. "Anti-Inflammatory Activity of Phytoconstituents of Ginseng Plant- Insilico Approach." Biomedical and Pharmacology Journal 16, no. 2 (2023): 1179–88. http://dx.doi.org/10.13005/bpj/2698.

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Ginseng is a plant’s root of the Panax family that is characterized by the presence of ginsenosides. It is used as a traditional medicine for many years in East Asian regions generally as an adaptogenic medicine to make the body resistant to homeostasis and other adverse environmental factors. Inflammation and lipid signaling are intermixed modulators of homeostasis and immunity. Cyclooxygenase is a key enzyme in lipid signalling. The present study focused on the anti-inflammatory analysis of phytoconstituents of the ginseng plant against COX1 and COX2 genes. In this study we approached the st

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Premkumar, Balasekar, Chandrasekar Leela Priyanka, Calamur Nagarajan Nalini, and Mahalakshmi. "Exploring the therapeutic potential of phytoconstituents in treatment of polycystic ovarian syndrome: An study." Indian Journal of Pharmacy and Pharmacology 10, no. 2 (2023): 94–101. http://dx.doi.org/10.18231/j.ijpp.2023.020.

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Polycystic ovary syndrome (PCOS) is a prevalent condition among women of reproductive age, characterised by hyperinsulinemia, hyperandrogenism, menstrual irregularities, and long-term metabolic disturbances. At present, the conventional approach to managing PCOS involves implementing lifestyle changes, administering pharmacological interventions, and performing surgical procedures. Nevertheless, these therapies do not exhibit promising outcomes for the comprehensive eradication of it. Consequently, natural sources have been regarded as a highly esteemed means of medication and aid in enhancing

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Hitesh, Verma, Baboo Prasad Shyam, Yashwant, and Singh Harmanpreet. "Herbal Drug Delivery System: A Modern Era Prospective." International Journal of Current Pharmaceutical Review and Research 4, no. 3 (2013): 88–101. https://doi.org/10.5281/zenodo.12690294.

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Plant based medicines are used from ancient time for treatment of diseases. In some cases desirable effect arenot achived beacause the biological action of herbal medicine is due to phytoconstituents which can vary batchto batch. The amount of phytoconstituent in a plant can vary according to age of plant, time of collection,environmental condition etc. To overcome this problem standardized medicinal plants, plant extracts andisolated constiturnts can be used. But in case of most of herbal medicine stability as well as absorption is thelimiting factor. Novel drug delivery system (NDDS) play ve

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Khan, Heena, Vivek Rihal, Thakur Gurjeet Singh, and Amarjot Kaur Grewal. "Therapeutic Implication of Herbal Phytoconstituents in Stroke." Journal of Pharmaceutical Technology, Research and Management 9, no. 2 (2021): 59–66. http://dx.doi.org/10.15415/jptrm.2021.92006.

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Introduction: Ischemic stroke is a prominent global cause of death and disability. Other than employingischemic stroke treatment with recombinant tissue plasminogen activator, which must be administered within 3 hours of an acute incident and carries a high risk of hemorrhagic complications, there is currentlya few effective stroke treatment should be done. Herbal medicines, mainly derived from plants, are an excellent source for developing novel therapeutic agents for a wide range of human illnesses. In additionally, the multifaceted influence of herbal medicine and its active ingredients on

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Khan, Heena, Vivek Rihal, Thakur Gurjeet Singh, and Amarjot Kaur Grewal. "Therapeutic Implication of Herbal Phytoconstituents in Stroke." Journal of Pharmaceutical Technology, Research and Management 9, no. 2 (2021): 59–66. http://dx.doi.org/10.15415/jptrm.2022.92006.

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Introduction: Ischemic stroke is a prominent global cause of death and disability. Other than employingischemic stroke treatment with recombinant tissue plasminogen activator, which must be administered within 3 hours of an acute incident and carries a high risk of hemorrhagic complications, there is currentlya few effective stroke treatment should be done. Herbal medicines, mainly derived from plants, are an excellent source for developing novel therapeutic agents for a wide range of human illnesses. In additionally, the multifaceted influence of herbal medicine and its active ingredients on

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Pichaiyan, Vignesh, Sasikala Mariyappan, Renuka Saravanan, and Sivakumar Ramalingam. "HERBAL REMEDY FOR OSTEOSARCOMA - CHALLENGING EVOLUTION." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 52. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.25706.

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Bone cancer is the extremely rare type, which accounts for about 0.2% of all cancer. They metastasize the cancer cells to the bone parts which have an especially crucial mechanism of action while treating. It is treated with the advanced drugs, have effluent side effects when compared to the medicinal plants and phytoconstituents. The review effectively deals that the mechanism of action of different medicinal plants include Phyllanthus urinaria, Aralia elata, Punica granatum, Anemone altaica, and Potentilla chinensis and the phytoconstituents include corosolic acid, shikonin, thymoquinone, al

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Sharma, Deepa, and Mohd Yusuf. "In Silico Docking Analysis of Bioactive Phytoconstituents for Targeting Glucose Transporters." Jabirian Journal of Biointerface Research in Pharmaceutics and Applied Chemistry 1, no. 5 (2024): 16–21. https://doi.org/10.55559/jjbrpac.v1i5.428.

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This study aimed to explore the interactions between ten selected bioactive phytoconstituents, and the glucose transporter GLUT1, to evaluate their potential as therapeutic agents for glucose management. Utilizing in silico molecular docking and molecular dynamics simulations, we assessed the binding affinities and stability of these phytoconstituents with GLUT1. Molecular docking revealed that Gymnemic Acid and Rutin exhibited superior binding affinities compared to other phytoconstituents, suggesting strong interactions with GLUT1. Molecular dynamics simulations further demonstrated that the

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Raval, Sadanand Eknath, Seema R. Sapale, Vikas V. Vaidya, and Amit Gosar. "Development and Validation of Derivatization Method for Simultaneous Quantitation of Asteracantha longifolia (L.) Nees Phytoconstituents by Liquid Chromatography–Electrospray Ionization–Mass Spectrometry/Mass Spectrometry." Asian Journal of Pharmaceutical Research and Health Care 16, no. 1 (2024): 74–83. http://dx.doi.org/10.4103/ajprhc.ajprhc_132_23.

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ABSTRACT Background: Betulin, lupeol, stigmasterol, and β-sitosterol are the active phytoconstituents accountable for the practical application of Asteracantha longifolia (L.) Nees in ayurvedic treatments as antitumor, hypoglycemic, aphrodisiac, antibacterial, free radical scavenging, lipid peroxidation, and hepatoprotective agent. As an essential medicinal plant in modern and traditional medicine, regularly checking raw material’s quality attributes and quantifying the phytoconstituents is indispensable. Aim: The aim of this study was to optimize derivatization conditions of these four essent

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Kumari, P., S. Kumar, K. V. Rajendran, R. K. Brahmchari, and R. P. Raman. "Effects of extraction temperature on phytoconstituents of leaf extracts of Azadirachta indica and its antiparasitic efficacy against Argulus sp." Journal of Environmental Biology 44, no. 5 (2023): 699–705. http://dx.doi.org/10.22438/jeb/44/5/mrn-5021.

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Aim: To understand the effect of extraction temperatures on the phytoconstituents of dried and fresh neem (Azadirachta indica) leaf extracts and its antiparasitic efficacy (AE %) against Argulus sp., an ectoparasite of fish. Methodology: Extracts of fresh and dried neem leaf were prepared using water at three different temperatures viz. room temperature (26 °C) for 24 hr, cold extraction (4 °C) for 24 hr and hot extraction (60°C) for 15 min, respectively. The preliminary qualitative and high-performance thin liquid chromatography analysis was conducted to estimate the phytoconstituents of each

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Sundriyal, Ankush, and Minky Mukhija. "Phytoconstituents responsible for anti-inflammatory activity." Journal of Natural Pharmaceuticals 4, no. 1 (2013): 1. http://dx.doi.org/10.4103/2229-5119.110340.

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Zhou, Li, Senye Wang, Jiaojiao Qu, et al. "Anti-Inflammatory Phytoconstituents of Origanum Majorana." Journal of Food Quality 2022 (May 23, 2022): 1–7. http://dx.doi.org/10.1155/2022/3888075.

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Origanum majorana belongs to the Lamiaceae family as a famous spice plant in Egypt, which is used to treat arthritis, allergies, fever, flu, hypertension, respiratory infections, migraine, and asthma. In our studies, it was found that the ethanol extract of O. marjoram could significantly reduce NO release at 200 ( P < 0.001 ), 100 ( P < 0.001 ) and 50 ( P < 0.01 ) μg/mL compared with the model group. Therefore, the chemical constituents were further studied to obtain the bioactive compounds. As a result, ten compounds were isolated and identified from the 70% ethanol extract of O. ma

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Saraf, S., and CD Kaur. "Phytoconstituents as photoprotective novel cosmetic formulations." Pharmacognosy Reviews 4, no. 7 (2010): 1. http://dx.doi.org/10.4103/0973-7847.65319.

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Singh, Amritpal, Sanjeev Duggal, Harmanpreet Singh, Jaswinder Singh, and Shankar Katekhaye. "Withanolides: Phytoconstituents with significant pharmacological activities." International Journal of Green Pharmacy 4, no. 4 (2010): 229. http://dx.doi.org/10.4103/0973-8258.74130.

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Ferreira, G. L. S., L. M. D. Bezerra, I. L. A. Ribeiro, R. C. D. Morais Júnior, and R. D. Castro. "Susceptibility of cariogenic microorganisms to phytoconstituents." Brazilian Journal of Biology 78, no. 4 (2018): 691–96. http://dx.doi.org/10.1590/1519-6984.174147.

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Abstract This study aimed to evaluate the in vitro antibacterial activity of the phytochemicals thymol, linalool, and citronellol against Streptococcus mutans, Streptococcus salivarius and Streptococcus oralis. Disk diffusion screening on solid medium and measurement of the diameter of the bacterial growth inhibition halos was the technique utilized. The Minimum Inhibitory Concentration (MIC) of the substances was determined using serial substance dilutions and microdilution technique in Brain Heart Infusion culture medium. After incubation for 24 hours in an oven at 37 °C, plate reading was c

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Abu-Reidah, Ibrahim M., and Amani Taamalli. "Promising Phytoconstituents in Antiangiogenesis Drug Development." Nutraceuticals 4, no. 4 (2024): 450–68. http://dx.doi.org/10.3390/nutraceuticals4040027.

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Angiogenesis, the process of forming new blood vessels from existing ones, is crucial in both physiological and pathological conditions, such as tumor growth, metastasis, and inflammatory disorders. Targeting angiogenesis has emerged as a promising therapeutic strategy. Recent research has increasingly focused on the role of bioactive components found in food in regulating angiogenesis, although there are certain limitations. This review provides a comprehensive examination of the origins, composition, pharmacological activities, and mechanisms of action of these components in medicinal foods,

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B, PRASANTH, AMRUTHA SOMAN, JOBIN JOHNSON, PARVATHY S. NARAYANAN, and AMALA P. JOHN. "PLANTS AND PHYTOCONSTITUENTS HAVING SUNSCREEN ACTIVITY." World Journal of Current Medical and Pharmaceutical Research 02, no. 01 (2020): 14–20. http://dx.doi.org/10.37022/wjcmpr.2020.02019.

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K. Yadav, Akhilesh, Jyoti Agrawal, Anirban Pal, and Madan M. Gupta. "Novel anti-inflammatory phytoconstituents fromDesmodium gangeticum." Natural Product Research 27, no. 18 (2013): 1639–45. http://dx.doi.org/10.1080/14786419.2012.761620.

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Chen, Shao-Nong, J. Brent Friesen, Donna Webster, et al. "Phytoconstituents from Vitex agnus-castus fruits." Fitoterapia 82, no. 4 (2011): 528–33. http://dx.doi.org/10.1016/j.fitote.2010.12.003.

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Ravi, S., and A. J. Lakshmanan. "ChemInform Abstract: Phytoconstituents of Artemisia vulcaris." ChemInform 32, no. 32 (2010): no. http://dx.doi.org/10.1002/chin.200132189.

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Lim, Vuanghao, Edward Schneider, Hongli Wu, and Iok-Hou Pang. "Cataract Preventive Role of Isolated Phytoconstituents: Findings from a Decade of Research." Nutrients 10, no. 11 (2018): 1580. http://dx.doi.org/10.3390/nu10111580.

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Cataract is an eye disease with clouding of the eye lens leading to disrupted vision, which often develops slowly and causes blurriness of the eyesight. Although the restoration of the vision in people with cataract is conducted through surgery, the costs and risks remain an issue. Botanical drugs have been evaluated for their potential efficacies in reducing cataract formation decades ago and major active phytoconstituents were isolated from the plant extracts. The aim of this review is to find effective phytoconstituents in cataract treatments in vitro, ex vivo, and in vivo. A literature sea

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Mane, JM, JS Jagtap, SS Chitlange, and DH Nagore. "Nardostachys jatamansi: A Review on Extraction Isolation Bioactivities of Phytoconstituents Chemical Structures and Traditional Uses." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 475–84. http://dx.doi.org/10.25258/ijpqa.15.1.73.

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Nardostachys jatamansi, commonly known as “jatamansi,” is a perennial herbaceous plant renowned for its medicinal properties. The rhizomes of N. jatamansi have been traditionally used in various medicinal practices owing to their therapeutic benefits. This abstract delves into the extraction process and isolation of phytoconstituents from N. jatamansi rhizomes, elucidating the extraction, purification, and structural analysis methods. The extraction of bioactive compounds from N. jatamansi rhizomes commonly employs soxhlet extraction, percolation, and maceration extraction techniques. These me

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Borse, Swapnil, Manali Joshi, Akash Saggam, et al. "Ayurveda botanicals in COVID-19 management: An in silico multi-target approach." PLOS ONE 16, no. 6 (2021): e0248479. http://dx.doi.org/10.1371/journal.pone.0248479.

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The Coronavirus disease (COVID-19) caused by the virus SARS-CoV-2 has become a global pandemic in a very short time span. Currently, there is no specific treatment or vaccine to counter this highly contagious disease. There is an urgent need to find a specific cure for the disease and global efforts are directed at developing SARS-CoV-2 specific antivirals and immunomodulators. Ayurvedic Rasayana therapy has been traditionally used in India for its immunomodulatory and adaptogenic effects, and more recently has been included as therapeutic adjuvant for several maladies. Amongst several others,

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Gaikwad, Dinanath T., Suraj P. Bansode, Dipak P. Mali, Ganesh H. Wadkar, Vijaykumar T. Pawar, and Firoj A. Tamboli. "Promising Discovery of Alpha Amylase Enzyme Inhibitors from Terminalia arjuna for Antidiabetic Potential." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 03 (2022): 1020–24. http://dx.doi.org/10.25258/ijddt.12.3.17.

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The aim of this work was to discover alpha amylase inhibitors from selected phytoconstituents of Terminalia arjuna by utilizing computational and in-silico methodology. Identified 37 phytoconstituents of T. arjuna were docked as test molecules. The complex structure of alpha-amylase in associated with Acarviostatin I03 was retrieved from protein data bank. Molecular screening by GA-based was performed to generate the cavity-enabled complex prototype using VLife MDS 4.4 software. Docking was used to identify the potent alpha-amylase inhibitor. Ligand-enzyme poses of the selected T. arjuna phyto

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