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Dissertations / Theses on the topic 'PI3K-Akt signaling pathway'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

MANSOURY, WALAA. "Exploring the role of PI3K/AKT signaling pathway in myxoid liposarcoma." Doctoral thesis, Università degli studi di Brescia, 2021. http://hdl.handle.net/11379/554950.

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2

Fraser, Sasha. "Development of Dual-Pathway Inhibitors of Raf/MEK/ERK and PI3K/Akt Signaling Pathways." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2619.

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In the present study, we designed a new chemical template that contains an oxindole moiety as potential dual-pathway inhibitors of the Raf/MEK/ERK and PI3K/Akt signaling pathways. The design hypothesis is to evaluate whether the oxindole ring system will approximately orient functional groups in a similar manner to the thiazolidinedione moiety, and thus maintain biological activity as dual-pathway inhibitors of the Raf/MEK/ERK and PI3K/Akt signaling pathways. Furthermore, the oxindole ring will provide the flexibility to allow the introduction of various substituents on the oxindole moiety, th

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3

Pérez-Tenorio, Gizeh. "Alterations in the PI3K/AKT Signaling Pathway and Response to Adjuvant Treatment in Breast Cancer." Doctoral thesis, Linköpings universitet, Onkologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-15043.

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(PI3K)/AKT signaling pathway could be a cause of therapeutic resistance in breast cancer. The PI3K/AKT pathway controls cell proliferation, cell growth and survival, and its members include oncogenes and tumor suppressor genes. Alterations in this pathway are frequent in cancer. In this thesis, we aimed to study the biological significance of some of these alterations in a tumor context as well as their clinical value. PIK3CA gene, encoding the PI3K catalytic subunit, was examined for mutations. The tumor suppressor PTEN, that counteracts PI3Kmediated effects, was studied at the protein level

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4

Cremer, Thomas John IV. "Mechanisms of Host-Defense Against Intracellular Bacterial Pathogens Through The PI3K/Akt Host Signaling Pathway." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1289571696.

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ULTIMO, Simona. "Inhibition of the PI3K/Akt/mTOR signaling pathway as a therapeutic target for Acute Lymphoblastic Leukemia." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2487845.

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Acute Lymphoblastic Leukemia (ALL) is a malignant disorder characterized by the abnormal clonal proliferation of B-cell progenitors (B-ALL) or immature stage thymocytes (T-ALL). Constitutive activation of the PI3K/Akt/mTOR network is a common feature of B- and T-ALL, influencing cell growth and survival. The PI3K/Akt/mTOR inhibitors are currently being developed for clinical use either as single agents or in combination with conventional chemotherapy for T-ALL patient treatment. In this study it has been investigated the effects of a panel of PI3K/Akt/mTOR inhibitors on healthy human CD4+ T-c

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Wright, Lilyan Yi Tian. "The activity of the helix-loop-helix protein, E47, is regulated by the PI3K/Akt signaling pathway." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3258711.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed June 4, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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7

Moraes, Síntique Nunes Schulz. "Análise da expressão da proteína Akt em cultura de células de carcinomas epidermóides de cabeça e pescoço tratadas com curcumina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/23/23154/tde-08082016-105511/.

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Diversas alterações genéticas estão associadas à patogênese do carcinoma epidermoide (CE), neoplasia maligna mais comum de cabeça e pescoço. Algumas dessas alterações comprometem proteínas pertencentes à via de sinalização do Akt, envolvida em diferentes fenômenos celulares. Este trabalho teve como objetivo estudar a expressão da proteína pAkt em linhagens celulares de carcinomas epidermoides de cabeça e pescoço, de forma a verificar possíveis alterações na transcrição dessa molécula em células de CE tratadas com Curcumina. Foram utilizadas duas linhagens celulares de CE de cabeça e pescoço (F

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8

Müller, Anja. "Multiple outcomes for PI3K/Akt/mTOR targeting in non-Hodgkin lymphoma." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2015. http://dx.doi.org/10.18452/17284.

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Wachstumsfaktor bedingte Aktivierung des PI3K/Akt/mTOR Signalweg wirkt positiv auf Vermehrung und Überleben. Konstitutive Aktivierung des Signalweges in NHL ist jedoch an Tumorprogression und Therapieresistenz beteiligt. Am Zelllinienmodell wurden zwei mögliche Therapiestrategien der PI3K/Akt/mTOR Inhibition erprobt, PI3K Inhibition mit BKM120 und horizontale Kombination von Zytostatika mit PI3K/Akt/mTOR Inhibitoren Erstens, BKM120 hat Antitumoraktivität in NHL und induziert Zelltod. Auf molekularer Ebene führt BKM120 vermittelte Dephosphorylierung von CDK1 an Y15 zur Aktivierung des M-Phase

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9

She, Bin [Verfasser], and Ursula [Akademischer Betreuer] Klingmüller. "Dynamic Modeling of the PI3K/Akt Signal Transduction Pathway to Dissect the Distinct Cell Fate Decisions Triggered by PI3K/Akt Signaling in Hematopoietic System / Bin She ; Betreuer: Ursula Klingmüller." Heidelberg : Universitätsbibliothek Heidelberg, 2011. http://d-nb.info/1179229932/34.

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10

CANI, Alice. "Targeting the PI3K/Akt/mTOR signaling pathway as a new therapeutic strategy for personalized treatments in acute lymphoblastic leukemia." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2388996.

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Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by the uncontrolled proliferation of lymphoblasts that accumulate in the blood, bone marrow and other organs. It represents 20% of adult acute leukemia and is the most common leukemia in children. The signal transduction pathway mediated by phosphatidylinositol 3-kinase (PI3K)/ Akt/mammalian target of rapamycin (mTOR) plays a key role in the regulation of important events for cells such as proliferation, differentiation and apoptosis, but also for the development of cancer and resistance to chemotherapy. In fact, the

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Lonetti, Annalisa <1982&gt. "Study of PI3K/Akt signaling pathway as potential molecular target for T-cell acute lymphoblastic leukemia (T-ALL) treatment: pan-inhibition of PI3K catalitic isoforms as better therapeutic approach." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6763/1/Annalisa_Lonetti_tesi.pdf.

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Class I phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases consisting of a regulatory subunit and one of four catalytic subunits (p110α, p110β, p110γ or p110δ). p110γ/p110δ PI3Ks are highly enriched in leukocytes. In general, PI3Ks regulate a variety of cellular processes including cell proliferation, survival and metabolism, by generating the second messenger phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3). Their activity is tightly regulated by the phosphatase and tensin homolog (PTEN) lipid phosphatase. PI3Ks are widely implicated in human cancers, and in part

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Lonetti, Annalisa <1982&gt. "Study of PI3K/Akt signaling pathway as potential molecular target for T-cell acute lymphoblastic leukemia (T-ALL) treatment: pan-inhibition of PI3K catalitic isoforms as better therapeutic approach." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/6763/.

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Class I phosphatidylinositol 3-kinases (PI3Ks) are heterodimeric lipid kinases consisting of a regulatory subunit and one of four catalytic subunits (p110α, p110β, p110γ or p110δ). p110γ/p110δ PI3Ks are highly enriched in leukocytes. In general, PI3Ks regulate a variety of cellular processes including cell proliferation, survival and metabolism, by generating the second messenger phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3). Their activity is tightly regulated by the phosphatase and tensin homolog (PTEN) lipid phosphatase. PI3Ks are widely implicated in human cancers, and in part

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13

Papazoglou, Ioannis. "Cross-talk between insulin and serotonin signaling in the brain : Involvement of the PI3K/Akt pathway and behavioral consequences in models of insulin resistance." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T039/document.

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L’insuline et la sérotonine (5-HT) sont deux acteurs majeurs du maintien de l’homéostasie énergétique, fonction placée sous le contrôle de l’hypothalamus. En ciblant cette région, l’insuline remplit de nombreuses fonctions métaboliques via l’activation de la voie PI3K/Akt. La 5-HT exercent des effets biologiques similaires mais les voies de signalisation impliquées dans ces processus étaient jusqu’alors mal connues. De plus, il avait été démontré que la 5-HT est capable d’activer la voie PI3K/Akt/GSK3β dans l’hippocampe, mécanisme sous-tendant potentiellement les effets antidépresseurs du neur

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Su, Men. "Type 2 Diabetes Mellitus Acts as a Risk Factor for the Development of Early Stage Alzheimer’s Disease." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS121.

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Après le vieillissement, le diabète Mellitus de type 2 (DMT2) est le facteur de risque le plus important pour développer la maladie d'Alzheimer (MA). Le DMT2 est une maladie métabolique caractérisée par une hyperglycémie et une résistance à l’insuline qui se développe vers la cinquantaine et est fortement favorisée par l’obésité. Nous avons exploré l’impact potentiel du DMT2 sur le développement de la MA chez le Rat. Pour cela, nous avons utilisé un régime alimentaire cafétéria (RC) couplé à des injections de faibles doses de Streptozotocine (STZ) (STZ-CD). Les rats STZ-CD montrent des signes

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Joassard, Olivier. "Mécanismes moléculaires du contrôle de la masse musculaire sous l'action du β2-agoniste formotérol". Phd thesis, Université Jean Monnet - Saint-Etienne, 2013. http://tel.archives-ouvertes.fr/tel-01001862.

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Les β2-agonistes sont couramment utilisés pour prévenir et réduire les symptômes de l'asthme et de la bronchoconstriction induite par l'exercice. Mais, pris en quantités supérieures aux doses thérapeutiques, les β2-agonistes ont un effet anabolisant qui a été clairement démontré in vivo. Un certain nombre d'acteurs sont mis en jeu dans la réponse biologique du tissu musculaire aux β2-agonistes. L'un de ces acteurs est la voie de signalisation PI3K/Akt/mTOR, voie d'initiation de la traduction, ayant un rôle majeur dans la synthèse protéique. Dans ce contexte, notre première étude avait pour obj

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Varshochi, Rana. "Steroid receptors and cell proliferation : cross-talk with the PI3K/Akt signalling pathway." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441958.

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Batra, A. "The role of the PI3K/AKT signalling pathway during avian infectious bronchitis infection." Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3004963/.

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Infectious bronchitis is a highly contagious respiratory disease that results in reduced egg production and can be fatal in young birds. It has recently been identified as the most economically detrimental disease to the poultry industry. It is caused by the gammacoronavirus infectious bronchitis virus (IBV), which is endemic in most countries worldwide. All viruses modulate cellular processes to establish themselves within the cell. The cellular PI3K/AKT signalling pathway is often modified by viruses and plays a crucial role in the regulation of many cellular processes. In this project the a

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Tashkandi, Ghassan Yousuf. "Phosphoproteomic profiling and targeting of the PI3K/Akt/mTOR and MAPK pathways in ovarian cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28740.

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The PI3K/Akt/mTOR and MAPK pathways are frequently altered in ovarian cancer cells, making them potential candidates for targeted therapy. A more complete understanding of the complex interactions between the different proteins within the two pathways would assist in developing more effective treatment strategies to help overcome therapy resistance. The purpose of this project was to understand the phosphoproteomic changes in response to PI3K/mTOR inhibition in ovarian cancer cells and to identify potential mechanisms that may lead to targeted therapy resistance. To investigate the effect of i

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Islam, Mohammad Rafiqul. "The role of VEGF-induced PI3K/Akt signalling pathway in head and neck cancer cell migration." Thesis, University of Dundee, 2015. https://discovery.dundee.ac.uk/en/studentTheses/04003bda-82e0-4fab-bf6c-f3196bc752fb.

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The PI3K-Akt signalling pathway is a well-established driver of cancer progression. One key process promoted by Akt phosphorylation is tumour cell motility; however the mechanism of VEGF-induced Akt phosphorylation leading to motility remains poorly understood. Previously, it has been shown that Akt phosphorylation, induced by different factors, causes both stimulation and inhibition of motility in different cell types. However, differential phosphorylation of Akt at T308 and S473 residues by VEGF and its role in head and neck cancer cell motility and progression is unknown. The cell lines inv

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Lu, Chen. "Novel Therapeutic Approaches for Ischemic Heart and Brain Injury: Modulation of Toll-Like Receptor-Mediated Signaling Pathways and PI3K/Akt Signaling." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2343.

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Innate immune and inflammatory responses contribute to myocardial and cerebral ischemia/reperfusion (I/R) injury. Toll-like receptors (TLRs) play a critical role in the induction of innate immune and inflammatory responses via activation of nuclear factor kappa B (NF-κB). We have shown that activation of NF-κB contributes to myocardial and cerebral I/R injury. Indeed, inhibition of TLR4-mediated NF-κB activation significantly decreased myocardial and cerebral I/R injury via activation of PI3K/Akt signaling. PI3K/Akt signaling is an important pathway in regulating cellular survival and inflamma

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Geyer, Natalie [Verfasser], Heidi [Akademischer Betreuer] Hahn, Matthias [Gutachter] Dobbelstein, and Dieter [Gutachter] Kube. "Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma / Natalie Geyer ; Gutachter: Matthias Dobbelstein, Dieter Kube ; Betreuer: Heidi Hahn." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2018. http://d-nb.info/117397489X/34.

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Yuka, Sai. "The Effect of Amyloid-Beta on the Insulin Signalling Pathway in Neuroblastoma 2a (N2a) Cells: The Characterization of Insulin Resistance in Alzheimer’s Disease." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34248.

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7Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by accumulation and deposition of extracellular beta-amyloid peptides (Aβ) and intra-neuronal hyperphosphorylated tau in the brain. The insulin signalling pathway begins upstream at the insulin receptor (IR), where the intracellular insulin receptor substrate 1 (IRS1) is phosphorylated, thus propagating the signal downstream to the PI3K/Akt signalling pathway, which affects both the glycogen synthase kinase 3 beta (GSK3β), which is a tau kinase, and mTOR, which is a critical part of the mTORC1 and mTORC2 comple

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Phyu, Su Myat. "Targeting of the PI3K/AKT/mTOR signalling pathway and associated kinases in breast and colon cancer cells and response evaluation by molecular imaging techniques." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238576.

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The phosphatidylinositol-3-kinase/AKT (Protein Kinase B)/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling pathway, downstream of tyrosine kinase receptors, is upregulated in human cancers including breast and colon cancers. Glycogen synthase kinase 3 (GSK 3) is a serine/threonine protein kinase plays important role in various cellular processes including glycogen synthesis mediated by insulin signalling pathway. Moreover, 5' adenosine monophosphate activated protein kinase (AMPK), a crucial cellular energy sensor, has regulatory role in cell growth and proliferation through mTOR pathwa

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Tao, Jinhao, Yuehua Cui, Yu Duan, Nan Zhang, Congmin Wang, and Fayong Zhang. "Puerarin attenuates locomotor and cognitive deficits as well as hippocampal neuronal injury through the PI3K/Akt1/GSK-3 beta signaling pathway in an in vivo model of cerebral ischemia." IMPACT JOURNALS LLC, 2017. http://hdl.handle.net/10150/627062.

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Ischemic stroke causes irreversible damage to the brain. The hippocampus is a vulnerable region and plays an important role in cognition and locomotor activity. Puerarin is a phytoestrogen that has beneficial effects in treating neurological disorders. How puerarin protects against hippocampal injury and its molecular mechanisms remain to be elucidated. Transient global brain ischemia was induced by 4-vessel occlusion in adult male Sprague-Dawley rats. The rats were pretreated with puerarin alone or together with LY294002 (an PI3K inhibitor) before ischemia/ reperfusion (I/R). The open-and clo

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Philippon, Héloïse. "Étude de l'histoire évolutive des PI3K et des voies de signalisation associées." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1099/document.

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L'objectif principal de ma thèse a été la caractérisation de l'histoire évolutive des voies de signalisation au travers d'une double approche: (i) l'analyse phylogénétique de leurs composés; et (ii) l'identification et la caractérisation de leurs interactions par l'analyse des interactomes d'organismes modèles. Or, bien que de nombreux outils soient disponibles pour la reconstruction d'arbres de gènes individuels, peu de méthodes ont été développées pour l'étude d'un ensemble de protéines impliquées dans un même processus cellulaire. Pourtant, au sein de la cellule, la plupart des protéines ag

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Sadiq, Barzan A. "A dissection of class I phosphoinositide 3-kinase signalling in mouse embryonic fibroblasts and prostate organoids." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/278056.

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Class I PI3Ks are a family (α, β, δ and γ) of ubiquitous lipid kinases that can be activated by cell surface receptors to 3-phosphorylate PI(4,5)P2 (phosphatidylinositol(4,5)-bisphosphate) and generate the signalling lipid PI(3,4,5)P3. The PI(3,4,5)P3 signal then activates a diverse collection of effector proteins involved in regulation of cell migration, metabolism and growth. The importance of this network is evidenced by the relatively high frequency with which cancers acquire gain-of-function mutations in this pathway and huge efforts to make PI3K inhibitors to treat cancer. The canonical

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Wu, Kuo-Hui, and 吳國暉. "Berberine Inhibits Metastatic Potential of Ovarian Cancer Cells via PI3K/Akt Signaling Pathway." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/04107753842688707418.

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碩士<br>淡江大學<br>化學學系碩士班<br>99<br>Berberine, one of the effective anti-cancer components of Coptis Chinensis, is a type of isoquinoline alkaloid. It has been reported various anti-cancer effects in different human cancer cell lines. Other research reported that berberine inhibited migration and invasion via MAPK pathways of human tongue cancer cells. Here, we reported that berberine inhibits cell proliferation, migration, invasion and angiogenesis of human ovarian cancer cell lines. The effects were mediated through inhibiting EGFR and HER2/neu expression and their down-stream signalings such as

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Maiuri, Tamara Lise. "Specificity in PI3K-PKB/AKT-PTEN Signaling: Subcellular Locus-specific Functions of Pathway Targets." Thesis, 2010. http://hdl.handle.net/1807/26370.

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The PI3K-PKB/Akt-PTEN signal transduction pathway orchestrates a variety of fundamental cell processes and its deregulation is implicated in several human diseases, including cancer. While the importance of this pathway to many cellular functions is well established, the mechanisms leading to context-specific physiological outcomes in response to a variety of stimuli remain largely unknown. Spatial restriction of signaling events is one of the means to coordinate specific cellular responses. To investigate the subcellular locus-specific roles of the major PI3K effector PKB/Akt in various cell

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Ya-LuenYang and 楊亞倫. "Role of the PI3K/Akt signaling pathway in human glioma cells and Caenorhabditis elegans." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/59720377976910533444.

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博士<br>國立成功大學<br>基礎醫學研究所<br>101<br>There are many subtle and complicated signal transduction pathways within every creature on the planet. Respectively, every molecule controls minute pathological changes. However, among different species, the same transduction pathways may play different roles. Epigenetic regulation via abnormal activation of histone deacetylases (HDACs) is a mechanism that leads to cancer initiation and promotion. Activation of HDACs results in transcriptional upregulation of human telomerase reverse transcriptase (hTERT) and increases telomerase activity during cellular immo

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Wang, Ren-Wei, and 王人偉. "Silencing of PI3K/Akt signaling pathway in Huh7 cell affects hepatitis C virus replication." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/78679761962057261734.

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碩士<br>國立東華大學<br>生物技術研究所<br>98<br>Hepatitis C virus (HCV) is the major causative agent of post-transfusion hepatitis. In the developed countries, hepatitis caused by HCV is the prevalent one. Approximately 80% of those patients infected with HCV develop into a chronic hepatitis C and are at high risk of developing cirrhosis and hepatocellular carcinoma (liver cancer). Interactions between HCV and host cell signaling pathways have been reported. This study focuses on the interaction between HCV and the host liver cells. Using RNAi technology block a specific intercellular signaling pathway, the

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Hong, Jina. "Alcohol, obesity, and estrogen regulate mammary tumorigenesis through adiposity and the PI3K/Akt signaling pathway." Thesis, 2010. http://hdl.handle.net/2152/ETD-UT-2010-05-1264.

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Breast cancer is the most common cancer and the second leading cause of cancer deaths among women in the United States. Alcohol consumption increases breast cancer risk in women. It is unclear whether the effects of alcohol on mammary tumorigenesis are modified by body weight or exogenous estrogen. To determine if the effects of alcohol on mammary tumors are modified by body weight, mice of different body weights (lean, overweight, obese) consuming water or alcohol were injected subcutaneously with mammary cancer cells. To determine if the effects of alcohol on mammary tumors are modified by e

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Wu, Hsin-Jou, and 吳欣柔. "Cyclophilin A as a Downstream Effector of PI3K/Akt Signaling Pathway in Multiple Myeloma cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/12339627035976861498.

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碩士<br>國立東華大學<br>生命科學系<br>104<br>Multiple myeloma (MM) is a disease caused by abnormal plasma cell clones. Interleukin 6 (IL-6) is the in vivo growth factor for MM cells. It can activate PI3K/AKT pathway, JAK/STAT pathway and RAS/MAPK pathway. Cyclophilin A (CypA), a member of the peptidyl—prolyl isomerase (PPI) family, may function as a molecular signaling switch. Comparative proteomic studies have identified CypA as a potential downstream target of protein kinase B (Akt). This study confirmed that CypA is a downstream effector of the phosphatidylinositide 3-kinase (PI3K)/Akt signaling pathway

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Shen, Zih-Yuan, and 沈子元. "Investigation of the involvement of PRL in the PI3K/Akt signaling pathway during Drosophila eye development." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/51874359948904963758.

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碩士<br>慈濟大學<br>生命科學系碩士班<br>99<br>Phosphatase of regenerating liver (PRL) protein family showed high degree of correlation with cancer metastasis and it has been considered as a potential target for cancer therapy. However, PRL substrate has not yet been identified and its function in development is still unclear. PRL is highly conserved in among species. In Drosophila genome, it has only one PRL gene with about 70％ similarity to its human homologs, hPRL1, 2, and 3. Previous studies in our lab indicated that dmPRL knockdown caused cell death during Drosophila eye development. In this study we de

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Li, Hsiu-Fang, and 李秀芳. "Ligustrum lucidum Ait. inhibits melanogensis in B16F10 cells through activation of the ERK and PI3K/AKT signaling pathway." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/78934524358459487820.

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碩士<br>美和科技大學<br>生技科技系健康產業碩士班<br>104<br>The inhibition of tyrosinase is the most effective method to decrease melanin synthesis during the process of pigmentation. We attempted to find the whitening activity compounds present in many herbal medicines used for this purpose we also discuss their mechanism in melanin biosynthesis. In this study, we investigated the effects of Ligustrum lucidus Ait extract on melanogenesis, including the activation of melanogenesis signaling pathways. This results suggest that Ligustrum lucidus Ait extract inhibited include melanin synthesis and tyrosinase activit

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Chiu, Ying-Chen, and 邱瀅真. "Involvement of PI3K/Akt Signaling Pathway in Baroreflex Response Enhancement by Adrenomedullin in the Nucleus Tractus Solitarii of Rats." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/93905882773886278903.

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碩士<br>國立陽明大學<br>藥理學研究所<br>98<br>Adrenomedullin (ADM) is a 52-amino acid peptide that contributes to modulation of mean arterial blood pressure through both central and peripheral mechanisms. Previous studies have indicated that ADM in the nucleus tractus solitarii (NTS) enhances baroreceptor reflex (BRR) response through ADM receptor-mediated cAMP/protein kinase A (PKA) and NO/protein kinase G (PKG)-dependent mechanism. However, how PKA activate NO/PKG signaling is still unknown. In NTS, PI3K/Akt/nNOS signaling was reported to play an important role in central cardiovascular regulation. Recent

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Wu, Chunhu, and 吳軍滬. "7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects Against Experimental Traumatic Brain Injury via Activation of the PI3K/Akt Signaling Pathway." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/60264810782735704780.

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碩士<br>國防醫學院<br>生理學研究所<br>100<br>Traumatic brain injury (TBI) induces secondary biochemical changes thatresult in subsequent tissue damage and neurological deficits. Previousstudies have shown that brain-derived neurotrophic factor (BDNF)activation of tropomyosin-related kinase receptor B (TrkB) and itsdownstream of PI3K/Akt and MAPK signaling pathways is critical inneuronal survival. TrkB phosphorylation has also been reported toincrease BDNF expression through the CREB signaling pathway. However, the neuroprotective effects of TrkB activation on TBI are still unknown. In this study, we used 7

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Lee, Chuan-Chun, and 李權峻. "Galangin induces p53-independent S-phase arrest and apoptosis in human nasopharyngeal carcinoma cells through inhibiting PI3K-AKT signaling pathway." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/hs4x76.

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博士<br>國立中興大學<br>生物科技學研究所<br>106<br>Anti-cancer activity of 3,5,7-trihydroxyflavone (galangin) has been documented in a variety of cancer types; however, its effect on human nasopharyngeal carcinoma (NPC) cells remains undetermined. Herein, we show that galangin induces apoptosis of NPC cells, characterized by nuclear condensation, cleavage of pro-caspase-3 and poly ADP-ribose polymerase (PARP), and DNA fragmentation. Treatment with galangin also resulted in an S-phase cell cycle accumulation. Using the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002, protein kinase B (AKT) inhibitor MK

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Gao, Jhen-I., and 高振壹. "The role of PI3K/AKT/mTOR signaling pathway in LPS-induced increase of granulocyte colony stimulating factor (G-CSF) in macrophages." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/52321730893146443337.

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碩士<br>國立臺灣大學<br>生物化學暨分子生物學研究所<br>95<br>The Oct-2 factor was originally identified on the basis of its ability to bind to the octamer motif ATGCAAAT which is found in the promoters of several genes. Oct-2 belongs to the POU family composed of Oct-1, Oct-2, Pit-1, and Unc-86. In the previous studies, Oct-2 has been known as an important transcription factor for B cells and neuron cells. However, expression and function of Oct-2 in the macrophages is mostly unknown. Our recent results showed that expression of Oct-2 in the macrophages was induced by LPS. Moreover, our data suggest that LPS-induce

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Li, Cheng-Feng, and 李承峰. "Regulation of the PI3K/AKT Signaling Pathway by Advanced Glycation End-products, High Glucose and N-acetyl-L-cysteine in 3T3-L1 Preadipocytes." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/93017652716385956940.

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Wu, Chia-Cheng Joyce. "YB-1 is a downstream component of the PI3K/Akt signaling pathway and regulates EGFR in breast carcinoma : a mechanism for breast cancer growth." Thesis, 2006. http://hdl.handle.net/2429/18400.

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High level of activated or phosphorylated serine/threonine kinase Akt is commonly observed in aggressive breast cancer. Hence, the Akt signaling pathway has become a popular target for therapeutic interventions. Previously our lab discovered that phosphorylated Akt is co-expressed with a transcription/translation factor called the Y-box Binding Protein-1 (YB-1) and that Akt phosphorylates YB-1 at Ser102 in vitro. It was also found that YB-1, but not the YB-1 mutant in which Ser102 is mutated to alanine (YB-1A102), enhanced breast cancer cell growth. Since YB-1 was originally isolated as a DNA

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Ju-Chiun, Kang. "Studies on the Roles of Ras/PI3K/Akt and p38 MAPK/MSK1 in the Signaling Pathway of Peptidoglycan-Induced Cyclooxygenase-2 Expression in RAW264.7 Macrophages." 2004. http://www.cetd.com.tw/ec/thesisdetail.aspx?etdun=U0007-1704200714563092.

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Kang, Ju-Chiun, and 康如鈞. "Studies on the Roles of Ras/PI3K/Akt and p38 MAPK/MSK1 in the Signaling Pathway of Peptidoglycan-Induced Cyclooxygenase-2 Expression in RAW264.7 Macrophages." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/56669231103954137735.

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碩士<br>臺北醫學大學<br>藥理學研究所<br>92<br>Peptidoglycan (PGN), a cell wall component of Gram-positive bacteria,can induce multiple similar responses in immune system as same as lipopolysaccharide (LPS) which is well known as a main cell wall component of Gram-negative bacteria caused inflammations. Our previous study shown that PGN induced cyclooxygenase-2 (COX-2) expression via Ras/Raf-1/ERK and NF-B signaling pathway in RAW 264.7 macrophages (J. Biol. Chem., 279:20889-20897, 2004). In this study, we investigated the roles of Ras/PI3K/Akt and p38MAPK/MSK1 on PGN-induced COX-2 expression in RAW 264.7 m

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YU, CHIH-CHIA, and 余芝嘉. "Targeting of the PI3K/AKT/mTOR signaling pathway as an effective radiosensitizing strategy for the treatment of human oral squamous cell carcinoma in vitro and in vivo." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/62775039735888503311.

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博士<br>國立中正大學<br>分子生物研究所<br>104<br>Background: Radiation therapy (RT) is the current standard adjuvant approach for oral squamous cell carcinoma (OSCC) patients. Activation of the PI3K/AKT/mTOR signaling pathway has been linked to the decreased radiation responsiveness in human oral cancer. Thus, it limits efficacy of radiotherapy. In addition, this pathway has been considered to be a major contributor in radiation resistance in various tumors. Although a number of studies suggest that blockage of this pathway can in vitro and in vivo enhance the radiation response, its role in radioresistance

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Chang, Ya-Chieh, and 張雅捷. "17 beta-estradiol (E2) and Nicotine Can Increase Nicotinic Acetylcholine Receptor alpha9 ( nAChR alpha9 ) Gene Expression Through PI3K/Akt and MAPK Signaling Transduction Pathway in MCF-7 Human Breast Cancer Cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/55447019633638561261.

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碩士<br>臺北醫學大學<br>醫學技術學系<br>95<br>The purpose of this investigation is to study the effects of 17 beta-estradiol and nicotine on nicotinic acetylcholine receptor alpha9 ( nAChR alpha9 ) gene expression and the cross-linking signaling pathways in MCF-7 human breast cancer cells. Using physiological concentrations of 17 beta-estradiol ( 1 nM ) and nicotine ( 10 microM ) could increase nAChR alpha9 mRNA expression after 48 hours treatment. Using PI3K inhibitor, LY 294002, could block both cross-linking pathway in MCF-7. PD 98059 and SP 600 125, inhibitors of mitogen-activated protein kinase (MAPK)

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Adamo, Annalisa. "Extracellular vesicles mediate mesenchymal stromal cell-dependent regulation of B cell functions." Doctoral thesis, 2019. http://hdl.handle.net/11562/995162.

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Mesenchymal stromal cells (MSCs) are adult, multipotent cells of mesodermal origin representing the progenitors of all stromal tissues. MSCs possess significant and broad immunomodulatory functions affecting both adaptive and innate immune responses once MSCs are primed by the inflammatory microenvironment. Recently, the role of extracellular vesicles (EVs) in mediating the therapeutic effects of MSCs has been recognized. Nevertheless, the molecular mechanisms responsible for the immunomodulatory properties of MSC-derived EVs (MSC-EVs) are still poorly characterized. Therefore, we carried out

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Caleiras, Mariana Biscaia. "Targeted delivery of doxorubicin and C6-ceramide drug combinations to non-small cell lung cancer cells." Master's thesis, 2019. http://hdl.handle.net/10316/88212.

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Dissertação de Mestrado em Biotecnologia Farmacêutica apresentada à Faculdade de Farmácia<br>O cancro é, atualmente, a doença responsável pela segunda maior taxa de mortalidade a nível mundial. Entre todas as doenças oncológicas, o cancro do pulmão é o mais frequente e o mais fatal, por isso, representa uma necessidade médica relevante.Embora existam estratégias terapêuticas inovadoras para cancro do pulmão introduzidas recentemente, como os inibidores de tirosina cinase e os agentes anti-angiogénicos, a sua eficácia não é isenta de fenómenos de resistência. Para além disso, a quimioterapia co

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Geyer, Natalie. "Targeting the Hedgehog and PI3K/AKT/mTOR signaling pathways in rhabdomyosarcoma." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E53D-4.

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Carmo, Anália Georgina Vital do. "Effect of Temozolamide in the U-118 glioma cell line." Master's thesis, 2014. http://hdl.handle.net/10316/37305.

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Dissertação de Mestrado Integrado em Medicina apresentada à Faculdade de Medicina da Universidade de Coimbra.<br>Glioblastomas (GBM) are the most lethal subtype of astrocytomas, with a survival rate of 12 months after diagnosis. The gold standard treatment of GBM, which comprises surgery followed by the combination of radiotherapy and chemotherapy with temozolomide (TMZ), increases the survival rate to 14.6 months. The success of TMZ seems to be limited by the occurrence of chemoresistance that allows glioma cells to escape from death signaling pathways. The mechanisms of TMZ action and o

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Yang, Shih-Wei, та 楊世瑋. "Neuroprotective effects of insulin against methamphetamine-induced oxidative stress and apoptosis is mediated by PI3K-Akt and GSK-3β signaling pathways". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/98148106322483568985.

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碩士<br>國防大學管理學院<br>海底醫學研究所<br>98<br>Methamphetamine is an illegal drug of abuse from 1980, it can influence mental and physical condition of drugster. The neurotoxic of MA are well extensive, including that MA increased oxidative stress, destroyed the balance of calcium, influence the Bcl-2 protein family and direct hurted organelle. Few years ago, researchers discovered that insulin provided neuroprotection continually, including that insulin reduced oxidative stress and neural cell death, enhanced the expression of anti-apoptotic protein Bcl-2, inhibited caspase-3 over-expression and control

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Ma, Yuan-Fen, and 馬元芬. "Water extract of Rosa cymosa Tratt. inhibits melanogenesis in B16-F10 cells through activation of ERK and PI3K/AKT signaling pathways." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/ksy36e.

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碩士<br>美和科技大學<br>生技科技系健康產業碩士班<br>107<br>Rosa cymosa Tratt,a traditional Chinese herbal medicine, originally grows on low-altitude slopes, is an evergreen climbing shrub. It can grow under harsh environmental conditions and is highly resistant to drought stress, which is an important feature responsible for its biologically active ingredients.The present study explored the message delivery pathways for inhibition of melanin synthesis by Rosa cymosa Tratt water extracts RCTWE. From the results of this study, RCTWE can significantly inhibit melanin synthesis and tyrosinase activity, and reduces th

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