Relevant bibliographies by topics / PI4KA

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'PI4KA'

Author: Grafiati
Published: 4 June 2021
Last updated: 17 February 2022

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Journal articles on the topic "PI4KA"

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Borawski, Jason, Philip Troke, Xiaoling Puyang, et al. "Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication." Journal of Virology 83, no. 19 (2009): 10058–74. http://dx.doi.org/10.1128/jvi.02418-08.

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ABSTRACT Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and replication in human liver cells. To search for novel host factor proteins required for HCV replication, we screened a subgenomic genotype 1b replicon cell line (Luc-1b) with a kinome and druggable collection of 20,779 siRNAs. We identified and validated several enzymes required for HCV replication, including class III phosphatidylinositol 4-kinases (PI4KA and PI4KB), carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), and mevalonate (diphospho) decarboxylase. K
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Dorobantu, Cristina M., Christian Harak, Rahel Klein та ін. "Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα". Antimicrobial Agents and Chemotherapy 60, № 10 (2016): 6402–6. http://dx.doi.org/10.1128/aac.01331-16.

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ABSTRACTEncephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, bothin vitroand in cells. AG1478 impaired replication of EMCV and HCV but not that of an EMCV mutant previously shown to escape PI4KA inhibition. This work uncovers novel cellular and antiviral properties of AG1478, a compound previously regarded only as a cancer chemotherapy agent.
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Sun, Suqing, Peng Wang, Lijie Ren, Hongli Wang, Yanli Zhan, and Shimin Shan. "Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA." OncoTargets and Therapy Volume 14 (May 2021): 3319–33. http://dx.doi.org/10.2147/ott.s295552.

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Pagnamenta, Alistair T., Malcolm F. Howard, Eva Wisniewski, et al. "Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis." Human Molecular Genetics 24, no. 13 (2015): 3732–41. http://dx.doi.org/10.1093/hmg/ddv117.

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Klima, Martin, Adriana Baumlova, Dominika Chalupska та ін. "The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design". Acta Crystallographica Section D Biological Crystallography 71, № 7 (2015): 1555–63. http://dx.doi.org/10.1107/s1399004715009505.

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Phosphatidylinositol 4-phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4-kinases (PI4Ks) that synthesize PI4P, among which are PI4K IIβ and PI4K IIα. In this study, two crystal structures are presented: the structure of human PI4K IIβ and the structure of PI4K IIα containing a nucleoside analogue. The former, a complex with ATP, is the first high-resolution (1.9 Å) structure of a PI4K. These structures reveal new details such as high conformational heterogeneity of the lateral hydrophobic pocket of the C-lobe and together pr
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Tai, Andrew W., and Shadi Salloum. "The Role of the Phosphatidylinositol 4-Kinase PI4KA in Hepatitis C Virus-Induced Host Membrane Rearrangement." PLoS ONE 6, no. 10 (2011): e26300. http://dx.doi.org/10.1371/journal.pone.0026300.

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Balla, Andras, Yeun Ju Kim, Peter Varnai та ін. "Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase IIIα". Molecular Biology of the Cell 19, № 2 (2008): 711–21. http://dx.doi.org/10.1091/mbc.e07-07-0713.

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Type III phosphatidylinositol (PtdIns) 4-kinases (PI4Ks) have been previously shown to support plasma membrane phosphoinositide synthesis during phospholipase C activation and Ca2+ signaling. Here, we use biochemical and imaging tools to monitor phosphoinositide changes in the plasma membrane in combination with pharmacological and genetic approaches to determine which of the type III PI4Ks (α or β) is responsible for supplying phosphoinositides during agonist-induced Ca2+ signaling. Using inhibitors that discriminate between the α- and β-isoforms of type III PI4Ks, PI4KIIIα was found indispen
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Ziyad, Safiyyah, Jesse D. Riordan, Ann M. Cavanaugh, et al. "A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis." Cell Reports 22, no. 5 (2018): 1211–24. http://dx.doi.org/10.1016/j.celrep.2018.01.017.

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Sohn, Mira, Pavlina Ivanova, H. Alex Brown, et al. "Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions." Proceedings of the National Academy of Sciences 113, no. 16 (2016): 4314–19. http://dx.doi.org/10.1073/pnas.1525719113.

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Lenz-Majewski syndrome (LMS) is a rare disease characterized by complex craniofacial, dental, cutaneous, and limb abnormalities combined with intellectual disability. Mutations in the PTDSS1 gene coding one of the phosphatidylserine (PS) synthase enzymes, PSS1, were described as causative in LMS patients. Such mutations render PSS1 insensitive to feedback inhibition by PS levels. Here we show that expression of mutant PSS1 enzymes decreased phosphatidylinositol 4-phosphate (PI4P) levels both in the Golgi and the plasma membrane (PM) by activating the Sac1 phosphatase and altered PI4P cycling a
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Bojjireddy, Naveen, Janos Botyanszki, Gerald Hammond, et al. "Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels." Journal of Biological Chemistry 289, no. 9 (2014): 6120–32. http://dx.doi.org/10.1074/jbc.m113.531426.

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Dissertations / Theses on the topic "PI4KA"

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Taveneau, Cyntia. "Modélisation, purification et caractérisation des modules et domaines de la PI4KA humaine." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA114827/document.

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La phosphatidylinositol-4-kinase de type IIIα est une kinase de lipide eukaryote ubiquitaire qui synthétise le phosphatidylinositol-4-phosphate PtdIns(4)P de la membrane plasmique. Ce phosphoinositide est d’autant plus important qu’il tient un rôle majeur dans différentes voies de signalisation cellulaire, le traffic vésiculaire ainsi que dans l’identité des organelles. De plus, la PIK4A humaine est un facteur essentiel pour la réplication du virus de l’hépatite C (VHC). En effet, le recrutement du complexe de réplication du VHC par la protéine virale NS5A à la membrane du reticulum endoplasmi
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Edlund, Emelie, and Fredrik Nordling. "Belöningssystem : Morot eller piska?" Thesis, Umeå University, Umeå School of Business, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-22442.

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<p> </p><p>Alla har någon gång i sitt liv fått belöning för något de har gjort bra, det kan vara allt ifrån att få en klapp på axeln till att få bra betyg i skolan och ofta så går prestation och belöning hand i hand. Belöningssystem används överallt i olika former, medvetet eller omedvetet och det kan vara ett sådant system som hjälper företagen framåt och eftersom personalen är en viktig resurs i ett företag så är det viktigt att förtaget även vårdar de anställda. Belöning och motivation hör ihop eftersom personalen blir mer motiverade av att bli belönade på något sätt. I dagens säljorganisat
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Fjellström, Elin, and Johan Magnusson. "Polisers fysiska träning, morot eller piska?" Thesis, Umeå University, Basic training programme for Police Officers, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-27418.

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<p>Syftet med denna rapport är att undersöka hur den fysiska träningen inom ramen för friskvårdsarbete bedrivs inom polisen och varför man i dag inte har några fysiska krav för poliser. Bakgrunden till ämnesvalet ligger i vår uppfattning att det är konstigt att det ställs fysiska krav på polisstudenter och polisaspiranter men inte på färdiga poliser. Vi har gjort en teoretisk studie inom ämnet friskvård, främst fysisk träning, för att beskriva fördelarna med att satsa resurser på detta samt visa på faktorer som har betydelse för att en friskvårdssatsning skall bli framgångsrik. Sedan presenter
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Stoor, Per. "Pika Pika? Pikachu! : En kvalitativ spelanalys av de socialt uppmuntrande designelementen i Pokemon Go." Thesis, Umeå universitet, Institutionen för informatik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130591.

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This paper is about how the location based game Pokemon Go motivates players to play the game outdoors and defining the games design principles and how they encourage social interaction between players. The paper has made use of three different qualitative data gathering methods, a brief ethnographical field study, semi structured interviews and an analysis based on theoretical frameworks used for conducting research about video games. Players were found to play outside for three reasons, the freedom of using a smartphone to play location based games, Pokemon Go’s location based game technolog
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Larsson, Jonas, Anna Viklund, and Ragnar Östermark. "Morot och Piska : – en komparativ studie om missbrukarvård." Thesis, Örebro University, Department of Behavioural, Social and Legal Sciences, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2525.

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<p>Syftet med denna studie är att ur socialarbetarens perspektiv undersöka hur tvångsvård påverkar arbetet med missbrukare. Studien är komparativ och jämför arbetet med missbrukare på Åland som tillämpar finsk lagstiftning respektive Gotland som arbetar efter den svenska lagstiftningen. Metoden som använts är kvalitativ. Fyra socialarbetare med inriktning mot arbete med missbrukare har intervjuats. Intervjuerna har varit semistrukturerade med öppna frågor. Två socialarbetare har intervjuats från respektive land. Resultatet visar att de båda länderna har en klar syn på hur tvång och frivillighe
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Holmdahl, Hugo. "Piska eller morot : vilken extern motivationsmetod anses effektivast." Thesis, Mälardalens högskola, Akademin för hälsa, vård och välfärd, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-27581.

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Grape, Owe. "Mellan morot och piska : en fallstudie av 1992 års rehabiliteringsreform." Doctoral thesis, Umeå universitet, Sociologiska institutionen, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-60101.

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This thesis is a case study of the Swedish Rehabilitation Reform of 1992. Vocational rehabilitation is described as an organizational activity which takes place in the interaction between social policy regulations and organizational execution. The analytical point of departure is made up of two complementary theoretical perspectives (Chapter 3): New institutional theory and the concept of 'negotiated order'. New institutional theory can aid inter-organizational analysis as it assumes that organizations are not only influenced, but also permeated by institutional and technical frameworks. The '
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Bergström, Erik, and Linnea Tegelberg. "Morot och piska : Arbetsgivares syn på lojalitet - En kvalitativ studie." Thesis, Karlstads universitet, Fakulteten för ekonomi, kommunikation och IT, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-13580.

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Sundell, Michelle de Oliveira Torres 1980. "Niveis plasmáticos de pivka-II em pacientes com hepatite autoimune." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309385.

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Orientador: Gabriel Hessel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-18T22:49:00Z (GMT). No. of bitstreams: 1 Sundell_MichelledeOliveiraTorres_M.pdf: 9790795 bytes, checksum: e022890e64ed25ec30642d7884df363e (MD5) Previous issue date: 2011<br>Resumo: A hepatite autoimune (HAI) e uma doença inflamatória do fígado de etiologia desconhecida. As crianças e os adolescentes com doença hepática crônica tem o risco de desenvolver deficiência de vitamina K devido a má-absorção de lipídios e a ingestão dietética
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Agnew, Kelly Kathleen. "Butterfly oviposition behavior, pika biogeography, and lentiviral sequence evolution /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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Books on the topic "PI4KA"

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Das, Manoranjan. Araṇya-pīka. Sahitya Akademi, 1999.

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von, Friesen Otto. Ödets piska. Carlsson, 1993.

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Piotrowski, Mieczysław. Czerwona piłka: Dramaty. Instytut Badań Literackich PAN, Wydawnictwo, 2012.

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Pivka, Franjo A. Franjo Pivka, fotograf. Fotoklub Maribor, Fotogalerija Stolp, 2006.

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Pinka, Erik-Herbert. Kolonel Friedrich-Karl Pinka. E.-H. Pinka, 1997.

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Pinka, Erik-Herbert. Kolonel Friedrich-Karl Pinka. [s.n.], 1997.

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Pinka, Erik-Herbert. Kolonel Friedrich-Karl Pinka. E.-H. Pinka, 1997.

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Buxton, Ted. Piłka nożna: Dla młodych zawodników. Elipsa, 2005.

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Karaliĭchev, Angel. Zhitenata pitka =: The wheaten loaf. IK "Zelena vŭlna", 1993.

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Repishti, Sami. Pika loti: Tregime burgu. Pegi, 2009.

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Book chapters on the topic "PI4KA"

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Schaller, George B. "The Good Pika." In Tibet Wild. Island Press/Center for Resource Economics, 2012. http://dx.doi.org/10.5822/978-1-61091-232-7_7.

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Asada, Miho, Shuro Yoshikawa, Nobutatsu Mochizuki, Yoshifumi Nogi, and Kyoko Okino. "Brief Report of Side-Scan Sonar Imagery Observations of the Archaean, Pika, and Urashima Hydrothermal Sites." In Subseafloor Biosphere Linked to Hydrothermal Systems. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54865-2_37.

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Morrison, Shawn F., and David S. Hik. "When? Where? and for How Long? Census Design Considerations for an Alpine Lagomorph, the Collared Pika (Ochotona collaris)." In Lagomorph Biology. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-72446-9_7.

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Toki, Tomohiro, Jun-ichiro Ishibashi, Takuroh Noguchi, et al. "Chemical and Isotopic Compositions of Hydrothermal Fluids at Snail, Archaean, Pika, and Urashima Sites in the Southern Mariana Trough." In Subseafloor Biosphere Linked to Hydrothermal Systems. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54865-2_45.

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Knez, Martin, Tadej Slabe, Franci Gabrovšek, et al. "Planning of the Motorway in the Pivka and Reka Rivers Catchment Areas, the Evaluation and Reduction of Impacts on Known Caves." In Cave Exploration in Slovenia. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21203-6_25.

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McPhail, Jacob A., and John E. Burke. "Drugging the Phosphoinositide 3-Kinase (PI3K) and Phosphatidylinositol 4-Kinase (PI4K) Family of Enzymes for Treatment of Cancer, Immune Disorders, and Viral/Parasitic Infections." In Druggable Lipid Signaling Pathways. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-50621-6_9.

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Nakamura, Kentaro, Hiroshi Sato, Patricia Fryer, and Tetsuro Urabe. "Petrography and Geochemistry of Basement Rocks Drilled from Snail, Yamanaka, Archaean, and Pika Hydrothermal Vent Sites at the Southern Mariana Trough by Benthic Multi-Coring System (BMS)." In Subseafloor Biosphere Linked to Hydrothermal Systems. Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54865-2_41.

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"PI4K2A." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_102904.

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"PIVKA." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_312978.

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"PIVKA II." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_312979.

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Conference papers on the topic "PI4KA"

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Sbrissa, Diego, Louie Semaan, Li Yanfeng, Assia Shisheva, and Sreenivasa R. Chinni. "Abstract 5162: Phosphatidylinositol 4-Kinase type IIIa (PI4KA) expression in prostate cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5162.

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Waring, Michael J., Darren Cross, David Andrews та ін. "Abstract 2228: Phosphatidylinositol-4-kinase - Potent and selective inhibitors of PI4Kα and PI4Kβ." У Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-2228.

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Shampur, K. K. "Acquaintance with the northern pika." In All-Russian scientific-practical conference of young scientists, graduate students and students, chair V. N. Protsenko and I. A. Poguliaeva. Технического института (ф) СВФУ, 2018. http://dx.doi.org/10.18411/a-2018-129.

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Dietrich, Robert, Frank Winkler, Andreas Knupfer, and Wolfgang Nagel. "PIKA: Center-Wide and Job-Aware Cluster Monitoring." In 2020 IEEE International Conference on Cluster Computing (CLUSTER). IEEE, 2020. http://dx.doi.org/10.1109/cluster49012.2020.00061.

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Nakao, Hikaru, Makoto Watanabe, Kazuo Sorai, et al. "Development of Nayoro optical camera and spectrograph for 1.6-m Pirka telescope of Hokkaido University." In SPIE Astronomical Telescopes + Instrumentation, edited by Suzanne K. Ramsay, Ian S. McLean, and Hideki Takami. SPIE, 2014. http://dx.doi.org/10.1117/12.2055399.

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Suzuki, S. "THE ABSORPTION, EXCRETION AND TRANSPLACENTAL TRANSPORT OF VITAMIN K IN THE PERINATAL PERIOD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644262.

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It is a well-known fact that hemorrhages are observed in wholly breastfed infants beyond the neonatal period. In order to clarify vitamin K (VK)-deficiency, it is necessary to follow-up the absorption and excretion of VK2.1. To 128 cases of newborns. i) The activity of VK-dependent factors(II, VII, X) were determined by Hepaplastin test(HPT), ii) Using Latex-test, PIVKA-II was tested. We found values of HPT (Y) and PIVKA-II (X) to be inversely proportional in the relation. Y=6l.9 - 6.7 X (r= -0.3). 2. These 15 cases of hypoprothrombinemia, VK2 6mg, VK2 2mgwere given, and plasma VK2-concentrati
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Noviansyah, Wahyu, and Itok Dwi Kurniawan. "School Culture That Supports Graduate Competency Development: A Case Study at SMK PIKA Semarang." In 1st International Conference on Character Education (ICCE 2020). Atlantis Press, 2021. http://dx.doi.org/10.2991/assehr.k.210204.040.

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De Pascale, Martina, Chiara Borsari, Erhan Keles, et al. "Abstract 291: Development of optimized chemical probes targeting PI3Ka to deconvolute the role of class I PI3Ks isoforms in insulin signaling." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-291.

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Hilton, John, Johanne Weberpals, Ian Lorimer, et al. "Abstract C1: BRCA1 protein levels and PI3KA mutations as predictive biomarkers for response to neoadjuvant chemotherapy in locally advanced breast cancer: An exploratory analysis." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1535-7163.targ-11-c1.

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Machin, S. J., H. Cohen, I. J. Mackie, M. Shearer, and S. D. Scott. "SERUM VITAMIN K1 LEVELS AS AN EARLY INDICATOR OF HYPOPROTHROMBINAEMIA ASSOCIATED WITH ANTIBIOTIC THERAPY." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644340.

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The prothrombin time is an insensitive indicator of early vitamin K deficiency and serum vitamin K1 levels may correlate with liver stores. A random non-fasting range of serum vitamin K1 was established in 45 healthy adults of 150-1,530 pg/ml (mean 412 pg/ml). Nine well nourished patients, with normal serum vitamin K1 levels, (mean 546, range 310-1,350 pg/ml), maintained normal prothrombin times and factor VII clotting activity throughout 7 days therapy with cefotetan disodium, an NMTT-containing cephalosporin antibiotic. However, 11 of 20 patients with acute intra-abdominal sepsis and an init
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Reports on the topic "PI4KA"

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Joseph Stewart, Joseph Stewart. Climate change threats to the American pika. Experiment, 2013. http://dx.doi.org/10.18258/0796.

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Copeland, M. J. Dioxycaris Fritzi Sp. Nov. [Arthropoda, Phyllocarida] From the Pika Formation [Middle Cambrian, Bolaspidella Zone], Jasper National Park, Alberta. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1986. http://dx.doi.org/10.4095/120437.

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Batten, George. Biogeography of the American Pika (Ochotona princeps) in Oregon and Southern Washington : illuminating genetic relationships among disjunct populations. Portland State University Library, 2000. http://dx.doi.org/10.15760/etd.5436.

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