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Journal articles on the topic 'PI4KA'

Author: Grafiati

Published: 4 June 2021

Last updated: 17 February 2022

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1

Borawski, Jason, Philip Troke, Xiaoling Puyang, et al. "Class III Phosphatidylinositol 4-Kinase Alpha and Beta Are Novel Host Factor Regulators of Hepatitis C Virus Replication." Journal of Virology 83, no. 19 (2009): 10058–74. http://dx.doi.org/10.1128/jvi.02418-08.

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ABSTRACT Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and replication in human liver cells. To search for novel host factor proteins required for HCV replication, we screened a subgenomic genotype 1b replicon cell line (Luc-1b) with a kinome and druggable collection of 20,779 siRNAs. We identified and validated several enzymes required for HCV replication, including class III phosphatidylinositol 4-kinases (PI4KA and PI4KB), carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD), and mevalonate (diphospho) decarboxylase. K

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2

Dorobantu, Cristina M., Christian Harak, Rahel Klein та ін. "Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα". Antimicrobial Agents and Chemotherapy 60, № 10 (2016): 6402–6. http://dx.doi.org/10.1128/aac.01331-16.

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ABSTRACTEncephalomyocarditis virus (EMCV), like hepatitis C virus (HCV), requires phosphatidylinositol 4-kinase IIIα (PI4KA) for genome replication. Here, we demonstrate that tyrphostin AG1478, a known epidermal growth factor receptor (EGFR) inhibitor, also inhibits PI4KA activity, bothin vitroand in cells. AG1478 impaired replication of EMCV and HCV but not that of an EMCV mutant previously shown to escape PI4KA inhibition. This work uncovers novel cellular and antiviral properties of AG1478, a compound previously regarded only as a cancer chemotherapy agent.

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3

Sun, Suqing, Peng Wang, Lijie Ren, Hongli Wang, Yanli Zhan, and Shimin Shan. "Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA." OncoTargets and Therapy Volume 14 (May 2021): 3319–33. http://dx.doi.org/10.2147/ott.s295552.

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4

Pagnamenta, Alistair T., Malcolm F. Howard, Eva Wisniewski, et al. "Germline recessive mutations in PI4KA are associated with perisylvian polymicrogyria, cerebellar hypoplasia and arthrogryposis." Human Molecular Genetics 24, no. 13 (2015): 3732–41. http://dx.doi.org/10.1093/hmg/ddv117.

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5

Klima, Martin, Adriana Baumlova, Dominika Chalupska та ін. "The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design". Acta Crystallographica Section D Biological Crystallography 71, № 7 (2015): 1555–63. http://dx.doi.org/10.1107/s1399004715009505.

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Phosphatidylinositol 4-phosphate (PI4P) is the most abundant monophosphoinositide in eukaryotic cells. Humans have four phosphatidylinositol 4-kinases (PI4Ks) that synthesize PI4P, among which are PI4K IIβ and PI4K IIα. In this study, two crystal structures are presented: the structure of human PI4K IIβ and the structure of PI4K IIα containing a nucleoside analogue. The former, a complex with ATP, is the first high-resolution (1.9 Å) structure of a PI4K. These structures reveal new details such as high conformational heterogeneity of the lateral hydrophobic pocket of the C-lobe and together pr

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6

Tai, Andrew W., and Shadi Salloum. "The Role of the Phosphatidylinositol 4-Kinase PI4KA in Hepatitis C Virus-Induced Host Membrane Rearrangement." PLoS ONE 6, no. 10 (2011): e26300. http://dx.doi.org/10.1371/journal.pone.0026300.

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Balla, Andras, Yeun Ju Kim, Peter Varnai та ін. "Maintenance of Hormone-sensitive Phosphoinositide Pools in the Plasma Membrane Requires Phosphatidylinositol 4-Kinase IIIα". Molecular Biology of the Cell 19, № 2 (2008): 711–21. http://dx.doi.org/10.1091/mbc.e07-07-0713.

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Type III phosphatidylinositol (PtdIns) 4-kinases (PI4Ks) have been previously shown to support plasma membrane phosphoinositide synthesis during phospholipase C activation and Ca2+ signaling. Here, we use biochemical and imaging tools to monitor phosphoinositide changes in the plasma membrane in combination with pharmacological and genetic approaches to determine which of the type III PI4Ks (α or β) is responsible for supplying phosphoinositides during agonist-induced Ca2+ signaling. Using inhibitors that discriminate between the α- and β-isoforms of type III PI4Ks, PI4KIIIα was found indispen

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8

Ziyad, Safiyyah, Jesse D. Riordan, Ann M. Cavanaugh, et al. "A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis." Cell Reports 22, no. 5 (2018): 1211–24. http://dx.doi.org/10.1016/j.celrep.2018.01.017.

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9

Sohn, Mira, Pavlina Ivanova, H. Alex Brown, et al. "Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions." Proceedings of the National Academy of Sciences 113, no. 16 (2016): 4314–19. http://dx.doi.org/10.1073/pnas.1525719113.

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Lenz-Majewski syndrome (LMS) is a rare disease characterized by complex craniofacial, dental, cutaneous, and limb abnormalities combined with intellectual disability. Mutations in the PTDSS1 gene coding one of the phosphatidylserine (PS) synthase enzymes, PSS1, were described as causative in LMS patients. Such mutations render PSS1 insensitive to feedback inhibition by PS levels. Here we show that expression of mutant PSS1 enzymes decreased phosphatidylinositol 4-phosphate (PI4P) levels both in the Golgi and the plasma membrane (PM) by activating the Sac1 phosphatase and altered PI4P cycling a

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Bojjireddy, Naveen, Janos Botyanszki, Gerald Hammond, et al. "Pharmacological and Genetic Targeting of the PI4KA Enzyme Reveals Its Important Role in Maintaining Plasma Membrane Phosphatidylinositol 4-Phosphate and Phosphatidylinositol 4,5-Bisphosphate Levels." Journal of Biological Chemistry 289, no. 9 (2014): 6120–32. http://dx.doi.org/10.1074/jbc.m113.531426.

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11

Balla, Andras, Galina Tuymetova, Arnold Tsiomenko, Péter Várnai, and Tamas Balla. "A Plasma Membrane Pool of Phosphatidylinositol 4-Phosphate Is Generated by Phosphatidylinositol 4-Kinase Type-III Alpha: Studies with the PH Domains of the Oxysterol Binding Protein and FAPP1." Molecular Biology of the Cell 16, no. 3 (2005): 1282–95. http://dx.doi.org/10.1091/mbc.e04-07-0578.

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The PH domains of OSBP and FAPP1 fused to GFP were used to monitor PI(4)P distribution in COS-7 cells during manipulations of PI 4-kinase (PI4K) activities. Both domains were associated with the Golgi and small cytoplasmic vesicles, and a small fraction of OSBP-PH was found at the plasma membrane (PM). Inhibition of type-III PI4Ks with 10 μM wortmannin (Wm) significantly reduced but did not abolish Golgi localization of either PH domains. Downregulation of PI4KIIα or PI4KIIIβ by siRNA reduced the localization of the PH domains to the Golgi and in the former case any remaining Golgi localizatio

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12

Karakas, Esra, Cyntia Taveneau, Stéphane Bressanelli, Massimo Marchi, Bruno Robert, and Stéphane Abel. "Derivation of original RESP atomic partial charges for MD simulations of the LDAO surfactant with AMBER: applications to a model of micelle and a fragment of the lipid kinase PI4KA." Journal of Biomolecular Structure and Dynamics 35, no. 1 (2016): 159–81. http://dx.doi.org/10.1080/07391102.2015.1135822.

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13

Tartaglione, Sara, Patrizia Mancini, Valentina Viggiani, Piero Chirletti, Antonio Angeloni, and Emanuela Anastasi. "PIVKA-II: A biomarker for diagnosing and monitoring patients with pancreatic adenocarcinoma." PLOS ONE 16, no. 5 (2021): e0251656. http://dx.doi.org/10.1371/journal.pone.0251656.

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Background Pancreatic adenocarcinoma (PDAC) is an incurable cancer without adequate tumor markers. Our previous study has showed a better diagnostic performance of Protein Induced by Vitamin K Absence II (PIVKA-II) compared to currently used PDAC biomarkers. To corroborate our previous data with a larger sample size and to assess a possible role of PIVKA-II in predicting surgical success. Additionally, to further evaluate the hypothesis of a direct PIVKA-II production by PDAC cells, we examined PIVKA-II tissue expression in a case of PDAC using immunofluorescence. Methods We enrolled 76 newly

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14

Xu, Fei, Lulu Zhang, Wenting He, Di Song, Xiaomeng Ji, and Jianyong Shao. "The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients." Disease Markers 2021 (February 8, 2021): 1–9. http://dx.doi.org/10.1155/2021/8868370.

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Background. At present, the diagnostic accuracy of alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) surveillance is insufficient. It remains controversial whether prothrombin induced by vitamin K absence II (PIVKA-II) has a better diagnostic value than AFP for HCC patients. Objective. To investigate the diagnostic role of PIVKA-II alone or in combination with AFP in Chinese HCC patients. Methods. Serum AFP and PIVKA-II levels were detected and analyzed in 308 HCC afflicted patients and 120 unafflicted controls. The receiver operator curve (ROC) and area under the curve (AUC) were con

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15

de Graaf, Petra, Wilbert T. Zwart, Remco A. J. van Dijken та ін. "Phosphatidylinositol 4-Kinaseβ Is Critical for Functional Association of rab11 with the Golgi Complex". Molecular Biology of the Cell 15, № 4 (2004): 2038–47. http://dx.doi.org/10.1091/mbc.e03-12-0862.

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Phosphatidylinositol 4-kinaseβ (PI4Kβ) plays an essential role in maintaining the structural integrity of the Golgi complex. In a search for PI4Kβ-interacting proteins, we found that PI4Kβ specifically interacts with the GTP-bound form of the small GTPase rab11. The PI4Kβ-rab11 interaction is of functional significance because inhibition of rab11 binding to PI4Kβ abolished the localization of rab11 to the Golgi complex and significantly inhibited transport of vesicular stomatitis virus G protein from the Golgi complex to the plasma membrane. We propose that a novel function of PI4Kβ is to act

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16

Widdershoven, J., P. van Munster, R. De Abreu, et al. "Four methods compared for measuring des-carboxy-prothrombin (PIVKA-II)." Clinical Chemistry 33, no. 11 (1987): 2074–78. http://dx.doi.org/10.1093/clinchem/33.11.2074.

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Abstract PIVKA-II (Protein Induced by Vitamin K Absence) is abnormal des-carboxylated prothrombin, which is present in vitamin K deficiency or in patients using warfarin. With a sensitive method for PIVKA-II, biochemical vitamin K deficiency can be established before clinical symptoms occur. We give an overview of methods used to detect PIVKA-II, and four selected methods are inter-compared: (a) measuring total factor II including PIVKA-II by using Echis carinatus snake venom as an activator of prothrombin; (b) measuring PIVKA-II by using snake venom as an activator of factor II after adsorpti

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17

von Kries, R., M. J. Shearer, J. Widdershoven, K. Motohara, G. Umbach, and U. Göbel. "Des-Gamma-Carboxyprothrombin (PIVKA II) and Plasma Vitamin K1 in Newborns and Their Mothers." Thrombosis and Haemostasis 68, no. 04 (1992): 383–87. http://dx.doi.org/10.1055/s-0038-1646281.

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SummaryAssessments of the vitamin K status in newborns and their mothers by means of des-γ-carboxy-prothrombin (PIVKA II) measurement have given equivocal results. Part of the variability could be attributed to differences in sensitivity (i.e. the ability to detect small concentrations) and validity (i.e. ability to detect vitamin K deficiency) of the methods applied. None of these methods have yet been validated with respect to plasma vitamin K1. In 22 healthy mother/infant pairs PIVKA II was determined using three different assays including ratio Xa/ecarin (Xa/ec), crossed immunoelectrophore

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18

Bovill, EG, RF Soll, M. Lynch, et al. "Vitamin K1 metabolism and the production of des-carboxy prothrombin and protein C in the term and premature neonate." Blood 81, no. 1 (1993): 77–83. http://dx.doi.org/10.1182/blood.v81.1.77.77.

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Abstract This study investigated the incidences of undercarboxylated (protein induced by vitamin K absence: PIVKA) prothrombin and protein C in 496 neonates across a wide range of gestational ages. These findings are related to vitamin K1 levels (an indicator of cofactor availability) and vitamin K1 epoxide levels (a measure of the efficiency of the hepatic vitamin K cycle). PIVKA protein C was present in at least trace amounts in 27% of infants; whereas, PIVKA prothrombin was present in 7% of infants. PIVKA prothrombin and protein C were present at high plasma concentrations in 2% to 3% of te

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Bovill, EG, RF Soll, M. Lynch, et al. "Vitamin K1 metabolism and the production of des-carboxy prothrombin and protein C in the term and premature neonate." Blood 81, no. 1 (1993): 77–83. http://dx.doi.org/10.1182/blood.v81.1.77.bloodjournal81177.

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This study investigated the incidences of undercarboxylated (protein induced by vitamin K absence: PIVKA) prothrombin and protein C in 496 neonates across a wide range of gestational ages. These findings are related to vitamin K1 levels (an indicator of cofactor availability) and vitamin K1 epoxide levels (a measure of the efficiency of the hepatic vitamin K cycle). PIVKA protein C was present in at least trace amounts in 27% of infants; whereas, PIVKA prothrombin was present in 7% of infants. PIVKA prothrombin and protein C were present at high plasma concentrations in 2% to 3% of term and pr

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20

Gandham, Goutham, Hridya Jayamohanan, Bharadwaj Ponnada, Anil Kumar, Sudhindran S, and Pavithran Keechilat. "Correlation of serum PIVKA-II and AFP level with portal vein tumor thrombus and BCLC stage in newly diagnosed hepatocellular carcinoma patients." Journal of Clinical Oncology 38, no. 15_suppl (2020): e16608-e16608. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e16608.

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e16608 Background: Protein Induced by Vitamin K Absence-II (PIVKA-II) is a tumor marker specific for hepatocellular carcinoma (HCC). PIVKA-II levels correspond with HCC oncogenesis and disease progression. Portal vein tumor thrombus (PVTT) in patients with HCC is a significant factor that affect treatment and prognosis. In this study we assessed the predictive value of PIVKA-II and AFP for vascular invasion and BCLC stage in newly diagnosed HCC patients. Methods: We retrospectively reviewed records of newly diagnosed HCC patients at a tertiary hospital in India between January 2019 to December

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21

Wood, Christopher S., Chia-Sui Hung, Yu-San Huoh, et al. "Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase." Molecular Biology of the Cell 23, no. 13 (2012): 2527–36. http://dx.doi.org/10.1091/mbc.e12-01-0077.

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In the Golgi apparatus, lipid homeostasis pathways are coordinated with the biogenesis of cargo transport vesicles by phosphatidylinositol 4-kinases (PI4Ks) that produce phosphatidylinositol 4-phosphate (PtdIns4P), a signaling molecule that is recognized by downstream effector proteins. Quantitative analysis of the intra-Golgi distribution of a PtdIns4P reporter protein confirms that PtdIns4P is enriched on the trans-Golgi cisterna, but surprisingly, Vps74 (the orthologue of human GOLPH3), a PI4K effector required to maintain residence of a subset of Golgi proteins, is distributed with the opp

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22

Melia, C. E., H. M. van der Schaar, A. W. M. de Jong, et al. "The Origin, Dynamic Morphology, and PI4P-Independent Formation of Encephalomyocarditis Virus Replication Organelles." mBio 9, no. 2 (2018): e00420-18. http://dx.doi.org/10.1128/mbio.00420-18.

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ABSTRACTPicornaviruses induce dramatic rearrangements of endomembranes in the cells that they infect to produce dedicated platforms for viral replication. These structures, termed replication organelles (ROs), have been well characterized for theEnterovirusgenus of thePicornaviridae. However, it is unknown whether the diverse RO morphologies associated with enterovirus infection are conserved among other picornaviruses. Here, we use serial electron tomography at different stages of infection to assess the three-dimensional architecture of ROs induced by encephalomyocarditis virus (EMCV), a mem

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Roberts, Michael Symmons. "Pika." Grand Street, no. 70 (2002): 179. http://dx.doi.org/10.2307/25008611.

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Sun, Hui-Chuan, Xiao-Dong Zhu, Cheng Huang, et al. "Early tumor marker decrease to predict the efficacy of combination therapy with lenvatinib plus anti-PD-1 antibodies in unresectable hepatocellular carcinoma (uHCC)." Journal of Clinical Oncology 39, no. 3_suppl (2021): 304. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.304.

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304 Background: Combination therapy with anti-angiogenic agents plus anti-PD-1 antibodies has shown high anti-tumor activity in uHCC. However, predicting the efficacy of this combination therapy remains a challenge. Methods: This study included consecutive patients with uHCC who received lenvatinib (8 mg/d regardless of body weight) and an anti-PD-1 antibody as first-line systemic therapy between Sep 2018 and July 2020, and had at least one imaging evaluation. Tumor response was assessed every 2 months (± 2 week) by the investigators using modified RECIST criteria. Patients were evaluated as h

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Yi, Shuhua, Jianjun Chen, Yu Qin, and Gaowei Xu. "The burying and grazing effects of plateau pika on alpine grassland are small: a pilot study in a semiarid basin on the Qinghai-Tibet Plateau." Biogeosciences 13, no. 22 (2016): 6273–84. http://dx.doi.org/10.5194/bg-13-6273-2016.

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Abstract. There is considerable controversy about the effects of plateau pika (Ochotona curzoniae, hereafter pika) on alpine grassland on the Qinghai-Tibet Plateau (QTP). On the one hand, pika is considered a keystone species. On the other hand, it is being poisoned. Although significant efforts have been made to study the effects of pika at a quadrat scale ( ∼ m2), our knowledge about its distribution and effects at a larger scale is very limited. In this study, we investigated the direct effects, i.e., burying and grazing, of pika by upscaling field sampling at a quadrat scale to a plot scal

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Zhang, Dongjing, Zhihong Liu, Xueru Yin, et al. "Prognostic value of PIVKA-II in hepatocellular carcinoma patients receiving curative ablation: A systematic review and meta-analysis." International Journal of Biological Markers 33, no. 3 (2018): 266–74. http://dx.doi.org/10.1177/1724600818760234.

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Background: Several studies have been conducted to evaluate the prognostic value of prothrombin induced by vitamin K absence-II (PIVKA-II) overexpression in hepatocellular carcinoma patients treated with curative ablation. However, the results remain controversial. The purpose of this meta-analysis was to explore the correlation between PIVKA-II expression and survival outcomes in these patients. Methods: We performed a systematic literature search in PubMed, EMBASE, Medline, Cochrane Library, and Web of Science to identify the relevant articles investigating the prognostic value of PIVKA-II i

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Maniscalco, Lorella, Katia Varello, Simona Zoppi, et al. "Abnormal Prothrombin (PIVKA-II) Expression in Canine Tissues as an Indicator of Anticoagulant Poisoning." Animals 11, no. 9 (2021): 2612. http://dx.doi.org/10.3390/ani11092612.

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PIVKA-II is an aberrant form of vitamin K that has been demonstrated to be increased in human coagulation disorders and in some neoplastic diseases. In veterinary medicine, PIVKA-II levels have been demonstrated to be useful for distinguishing anticoagulant poisoning from other coagulopathies. In forensic pathology, there is the need to distinguish malicious poisoning from other causes of death and, in some cases, identifying poisoned dogs from dogs that died as a result of other coagulative disorders can be challenging. In this study, dogs that suddenly died underwent necropsy, histological e

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Darmadi, Darmadi, and Riska Habriel Ruslie. "Association between Prothrombin Induced by Vitamin K Absence-II (PIVKA-II) and Barcelona Clinic Liver Cancer (BCLC) Stage, Tumor Size, Portal Venous Thrombosis in Hepatocellular Carcinoma Patients." Sains Malaysiana 50, no. 2 (2021): 475–80. http://dx.doi.org/10.17576/jsm-2021-5002-18.

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Hepatocellular carcinoma is one of the major cancer problems in the world because of the low early screening awareness in patients. Serum alpha-fetoprotein is not adequate as a single screening tool, especially for small HCCs, thus, prothrombin induced by vitamin K absence-II (PIVKA-II) can help in detecting small HCCs. Barcelona Clinic Liver Cancer (BCLC) stage remains to be the preferred HCC classification because it can predict the outcome and help in choosing available treatment options according to stages. This study aims to investigate the association between PIVKA-II levels with BCLC st

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Shrestha, Mohan Bikram, and Ritu Gurung. "Distribution of Royle’s Pika Ochotona roylei in Parvati Kunda Groundwater Complex." Nepal Journal of Environmental Science 7 (December 31, 2019): 11–15. http://dx.doi.org/10.3126/njes.v7i0.34318.

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Royle’s Pika Ochotona roylei is high altitude animal belonging to the family Ochotonidae in order Lagomorpha. Royle’s Pika was reported in different locations between an elevation of 2180 to 5950 meters above sea level (m asl). This study carried in February and October 2017 recorded a small population of Royle’s Pika in the Parvati Kunda Groundwater Complex of Gatlang village in Rasuwa District, Nepal. A total of 12 Royle’s pika individuals were head counted from three sites while Pika foraged plants were observed in other sites. Pika was observed in talus groove amidst Rhododendron-fir fores

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Caviglia, Gian Paolo, Michela Ciruolo, Maria Lorena Abate, et al. "Alpha-Fetoprotein, Protein Induced by Vitamin K Absence or Antagonist II and Glypican-3 for the Detection and Prediction of Hepatocellular Carcinoma in Patients with Cirrhosis of Viral Etiology." Cancers 12, no. 11 (2020): 3218. http://dx.doi.org/10.3390/cancers12113218.

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International guidelines recommend the use of ultrasound as a surveillance tool for hepatocellular carcinoma (HCC) in patients with cirrhosis, while the role of serum biomarkers is still debated. We investigated serum alpha-fetoprotein (AFP), protein induced by vitamin K absence or antagonist II (PIVKA-II) and glypican-3 (GPC-3) diagnostic accuracy for HCC detection and prediction in patients with liver cirrhosis of viral etiology under surveillance. A total of 349 patients (200 cirrhosis and 149 HCC) were enrolled. The 200 patients with cirrhosis consisted of 114 patients still HCC-free after

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Tartaglione, Sara, Teresa Granato, Emanuela Anastasi, et al. "Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study." Biochemia medica 29, no. 2 (2019): 352–58. http://dx.doi.org/10.11613/bm.2019.020707.

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Introduction: Protein induced by vitamin K absence II (PIVKA-II) is an abnormal prothrombin increased in gastrointestinal malignancy. We aimed to evaluate PIVKA-II in comparison to established pancreatic cancer (PC) biomarkers (CA 19-9, carcinoembryonic antigen (CEA) and CA 242) measured in PC patients and in patients with benign pancreatic diseases. Materials and methods: We studied 26 PC patients (Group 1) and 20 patients with benign pancreatic diseases (Group 2). PIVKA-II and CEA were measured by chemiluminescent enzyme immunoassay method (CLEIA) on LUMIPULSE G1200 (Fujirebio-Europe, Gent,

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Qin, Yu, Shuhua Yi, Yongjian Ding, et al. "Effect of plateau pika disturbance and patchiness on ecosystem carbon emissions in alpine meadow in the northeastern part of Qinghai–Tibetan Plateau." Biogeosciences 16, no. 6 (2019): 1097–109. http://dx.doi.org/10.5194/bg-16-1097-2019.

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Abstract. Plateau pika (Ochotona curzoniae) disturbance and patchiness intensify the spatial heterogeneous distribution of vegetation productivity and soil physicochemical properties, which may alter the ecosystem carbon emission process. Nevertheless, previous research has mostly focused on the homogeneous vegetation patches rather than heterogeneous land surface. Thus, this study aims to improve our understanding of the difference in ecosystem respiration (Re) over heterogeneous land surface in an alpine meadow grassland. Six different land surface types, namely large bald patches, medium ba

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Wu, Yi-Nan, Yu-Jun Ma, Wen-Ling Liu, and Wu-Zhao Zhang. "Modeling the Spatial Distribution of Plateau Pika (Ochotona curzoniae) in the Qinghai Lake Basin, China." Animals 9, no. 10 (2019): 843. http://dx.doi.org/10.3390/ani9100843.

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The plateau pika (Ochotona curzoniae) is a keystone species in the alpine rangeland ecosystem of the Qinghai–Tibetan Plateau. Most previous studies of habitat selection by plateau pika have been conducted at a local microhabitat scale; however, little is known about the relationship between the distribution of plateau pika and macrohabitat factors at broad spatial scales. Using a presence-only ecological niche model (maximum entropy, Maxent), we predicted the distribution of plateau pika in the Qinghai Lake basin based on a set of environmental and anthropogenic variables at 1-km spatial resol

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LIU, HANWU, LI ZHOU, WEI LIU, and HUAKUN ZHOU. "USING A CELLULAR-AUTOMATA MODEL TO INVESTIGATE THE EFFECTS OF GRAZING ON PLATEAU PIKA POPULATION DYNAMICS." International Journal of Biomathematics 04, no. 03 (2011): 275–87. http://dx.doi.org/10.1142/s179352451100126x.

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The plateau pika is a keystone species of Qinghai–Tibet plateau, but its overabundance aggravates the degradation of alpine meadow. Grazing is the most convenient manner to utilize alpine meadow. Grazing would change vegetation condition, that is, change the habitat of plateau pika and so lead to variation of plateau pika population. Based on ecological characteristics of plateau pika and alpine meadow, a cellular-automata model is established to investigate the influence of grazing on dynamics of plateau pika population. Vegetation shortens with the increase of grazing intensity. When grazing

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35

Dornan, Gillian L., Jacob A. McPhail, and John E. Burke. "Type III phosphatidylinositol 4 kinases: structure, function, regulation, signalling and involvement in disease." Biochemical Society Transactions 44, no. 1 (2016): 260–66. http://dx.doi.org/10.1042/bst20150219.

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Many important cellular functions are regulated by the selective recruitment of proteins to intracellular membranes mediated by specific interactions with lipid phosphoinositides. The enzymes that generate lipid phosphoinositides therefore must be properly positioned and regulated at their correct cellular locations. Phosphatidylinositol 4 kinases (PI4Ks) are key lipid signalling enzymes, and they generate the lipid species phosphatidylinositol 4-phosphate (PI4P), which plays important roles in regulating physiological processes including membrane trafficking, cytokinesis and organelle identit

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Wei, W. R., J. D. He, and Q. Y. Zheng. "Plateau pikas (Ochotona curzoniae) at low densities have no destructive effect on winter pasture in alpine meadows." Rangeland Journal 42, no. 1 (2020): 55. http://dx.doi.org/10.1071/rj19042.

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The plateau pika (Ochotona curzoniae) is a common small mammal species present in the alpine meadow ecosystem on the Qinghai-Tibetan Plateau (QTP), and is regarded as a pest in alpine meadows when population density exceeds a certain threshold. However, whether pikas with a low population density have a detrimental effect on alpine meadows in winter pasture is unknown. Vegetation and soil were sampled in eight individual pika patchy home ranges and eight control areas, and we found vegetation and soil properties showed different trends in the pika home ranges. Plateau pika activity significant

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Mikhaylova, Marina, Pasham Parameshwar Reddy, and Michael R. Kreutz. "Role of neuronal Ca2+-sensor proteins in Golgi–cell-surface membrane traffic." Biochemical Society Transactions 38, no. 1 (2010): 177–80. http://dx.doi.org/10.1042/bst0380177.

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The regulated local synthesis of PtdIns4P and PtdIns(4,5)P2 is crucial for TGN (trans-Golgi network)–plasma membrane trafficking. The activity of PI4Kβ (phosphoinositide 4-kinase IIIβ) at the Golgi membrane is a first mandatory step in this process. In addition to PI4Kβ activity, elevated Ca2+ levels are also needed for the exit of vesicles from the TGN. The reason for this Ca2+ requirement is at present unclear. In the present review, we discuss the role of neuronal Ca2+-sensor proteins in the regulation of PI4Kβ and suggest that this regulation might impose a need for elevated Ca2+ levels fo

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Mozrzymas, Renata, Dariusz Walkowiak, Sławomira Drzymała-Czyż, et al. "Vitamin K Status in Adherent and Non-Adherent Patients with Phenylketonuria: A Cross-Sectional Study." Nutrients 12, no. 6 (2020): 1772. http://dx.doi.org/10.3390/nu12061772.

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This is the first study to evaluate vitamin K status in relation to dietary intake and phenylalanine dietary compliance in patients with phenylketonuria (PKU). The dietary and PKU formula intake of vitamin K was calculated in 34 PKU patients, with vitamin K status determined by the measurement of prothrombin induced by vitamin K absence (PIVKA-II). Blood phenylalanine concentrations in the preceding 12 months were considered. There were significantly more phenylalanine results exceeding 6 mg/dL in patients with normal PIVKA-II concentrations than in those with abnormal PIVKA-II levels (p = 0.0

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Harrington, D. J., H. Western, C. Seton-Jones, S. Rangarajan, T. Beynon, and M. J. Shearer. "A study of the prevalence of vitamin K deficiency in patients with cancer referred to a hospital palliative care team and its association with abnormal haemostasis." Journal of Clinical Pathology 61, no. 4 (2007): 537–40. http://dx.doi.org/10.1136/jcp.2007.052498.

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Background:Many patients with advanced cancer are malnourished. Anorexia is common, as is the use of chemotherapy, which may cause nausea and poor appetite. Ten per cent of these patients experience haemorrhagic events.Aim:Since vitamin K deficiency (VKD) causes bleeding, to establish the prevalence of VKD in patients with advanced cancer receiving palliative care.Methods:Serum concentrations of vitamin K1 and undercarboxylated factor II (PIVKA-II) were determined in 46 (17 male/29 female) inpatients aged 26–85 (mean 58) years. INR and liver function tests (bilirubin, ALT, GGT and ALP) were al

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Kapp-Barnea, Yaara, Lihi Ninio-Many, Koret Hirschberg, Mitsunori Fukuda, Andreas Jeromin та Ronit Sagi-Eisenberg. "Neuronal Calcium Sensor-1 and Phosphatidylinositol 4-Kinase β Stimulate Extracellular Signal-regulated Kinase 1/2 Signaling by Accelerating Recycling through the Endocytic Recycling Compartment". Molecular Biology of the Cell 17, № 9 (2006): 4130–41. http://dx.doi.org/10.1091/mbc.e05-11-1014.

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We demonstrate that recycling through the endocytic recycling compartment (ERC) is an essential step in FcεRI-induced activation of extracellular signal-regulated kinase (ERK)1/2. We show that ERK1/2 acquires perinuclear localization and colocalizes with Rab 11 and internalized transferrin in FcεRI-activated cells. Moreover, a close correlation exists between the amount of ERC-localized ERK1/2 and the amount of phospho-ERK1/2 that resides in the nucleus. We further show that by activating phosphatidylinositol 4-kinase β (PI4Kβ) and increasing the cellular level of phosphatidylinositol(4) phosp

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Tonkyn, David, Kaitlyn Hanley, and Katie Quakenbush. "Factors influencing American Pika (Ochotona princeps) distributions in the Beartooth Mountains and implications of a warming climate." UW National Parks Service Research Station Annual Reports 39 (December 15, 2016): 43–50. http://dx.doi.org/10.13001/uwnpsrc.2016.5283.

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Over the next century, temperatures are expected to rise by 1-4°C in the Greater Yellowstone Region. This will force alpine species such as the American pika (Ochotona princeps) to compensate, shift in distribution, or disappear. If pika are limited by temperatures, they may disappear from warmer, lower elevation southwest-facing sites and find refuge in cooler, higher elevation northeast-facing sites. However, populations have been found across a range of elevations, suggesting they are instead limited by food or a need for large talus slopes. We explored these possibilities in the Beartooth

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Yang, Tian, Hao Xing, Guoqiang Wang, et al. "A Novel Online Calculator Based on Serum Biomarkers to Detect Hepatocellular Carcinoma among Patients with Hepatitis B." Clinical Chemistry 65, no. 12 (2019): 1543–53. http://dx.doi.org/10.1373/clinchem.2019.308965.

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Abstract BACKGROUND Early detection of hepatocellular carcinoma (HCC) among hepatitis B virus (HBV)-infected patients remains a challenge, especially in China. We sought to create an online calculator of serum biomarkers to detect HCC among patients with chronic hepatitis B (CHB). METHODS Participants with HBV-HCC, CHB, HBV-related liver cirrhosis (HBV-LC), benign hepatic tumors, and healthy controls (HCs) were recruited at 11 Chinese hospitals. Potential serum HCC biomarkers, protein induced by vitamin K absence or antagonist-II (PIVKA-II), α-fetoprotein (AFP), lens culinaris agglutinin A-rea

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Kondo, Akira, Hirokazu Kondo, Yoshihisa Nakagawa, et al. "Influence of Warfarin Therapy on Prothrombin Production and Its Posttranslational Modifications." Journal of Applied Laboratory Medicine 5, no. 6 (2020): 1216–27. http://dx.doi.org/10.1093/jalm/jfaa069.

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Abstract Background Protein induced by vitamin K absence-II (PIVKA-II) is produced by the liver during hepatoma and upon warfarin administration. Those patients have disturbed protein synthesis and glycosylation in the liver. This decreases the number of γ-carboxyglutamyl (Gla) residues on prothrombin, converting prothrombin into PIVKA-II. The mechanism of this conversion, however, is not clearly understood. Methods Prothrombin was isolated from healthy and warfarin-treated individuals whose liver function of protein production was quantitatively normal. Glycan structures in the purified proth

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Zhou, Jiyong, Wenbo Sun, Junhua Wang, et al. "Characterization of the H5N1 Highly Pathogenic Avian Influenza Virus Derived from Wild Pikas in China." Journal of Virology 83, no. 17 (2009): 8957–64. http://dx.doi.org/10.1128/jvi.00793-09.

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ABSTRACT The highly pathogenic H5N1 avian influenza virus emerged from China in 1996 and has spread across Eurasia and Africa, with a continuous stream of new cases of human infection appearing since the first large-scale outbreak among migratory birds at Qinghai Lake. The role of wild birds, which are the natural reservoirs for the virus, in the epidemiology of the H5N1 virus has raised great public health concern, but their role in the spread of the virus within the natural ecosystem of free-ranging terrestrial wild mammals remains unclear. In this study, we investigated H5N1 virus infection

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Li, Wei-Dong, and Andrew T. Smith. "Dramatic decline of the threatened Ili pika Ochotona iliensis (Lagomorpha: Ochotonidae) in Xinjiang, China." Oryx 39, no. 1 (2005): 30–34. http://dx.doi.org/10.1017/s0030605305000062.

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The Vulnerable Ili pika Ochotona iliensis (Lagomorpha: Ochotonidae) is a poorly known mammal species that inhabits a restricted geographic range in the Tian Shan Mountains, Xinjiang Uygur Autonomous Region, China. It was discovered in 1983, described in 1986, and subsequently investigated over the following decade. As no studies were conducted on this pika during the next 10 years, a comprehensive census was undertaken in the summers of 2002 and 2003, including all sites where it had previously been observed. Evidence of the Ili pika was found at only 6 of 14 sites censused, and was extinct in

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Wu, Liujie, Ayan Sadhukhan, Yuriko Kobayashi, et al. "Involvement of phosphatidylinositol metabolism in aluminum-induced malate secretion in Arabidopsis." Journal of Experimental Botany 70, no. 12 (2019): 3329–42. http://dx.doi.org/10.1093/jxb/erz179.

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Abstract To identify the upstream signaling of aluminum-induced malate secretion through aluminum-activated malate transporter 1 (AtALMT1), a pharmacological assay using inhibitors of human signal transduction pathways was performed. Early aluminum-induced transcription of AtALMT1 and other aluminum-responsive genes was significantly suppressed by phosphatidylinositol 4-kinase (PI4K) and phospholipase C (PLC) inhibitors, indicating that the PI4K–PLC metabolic pathway activates early aluminum signaling. Inhibitors of phosphatidylinositol 3-kinase (PI3K) and PI4K reduced aluminum-activated malat

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Li, Yaoming, Lili Jiang, Wangwang Lv, et al. "Fungal pathogens pose a potential threat to animal and plant health in desertified and pika-burrowed alpine meadows on the Tibetan Plateau." Canadian Journal of Microbiology 65, no. 5 (2019): 365–76. http://dx.doi.org/10.1139/cjm-2018-0338.

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Intact Tibetan meadows provide significant defense against soil-borne pathogen dispersal. However, dramatic meadow degradation has been observed due to climate change and pika damage, but their impacts on soil-borne pathogens are still unclear. With approximately 40% of the world’s population living in Tibetan Plateau and its downstream watersheds, this lack of knowledge should be of great concern. Here, we used Illumina amplicon sequencing to characterize the changes in potential human, domestic animal, plant, and zoonotic bacterial and fungal pathogens in nondegraded, desertified, and pika-b

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Shank, Christopher C. "Are American Pikas (Ochotona princeps) in the Canadian Rockies vulnerable to climate change?" Canadian Field-Naturalist 129, no. 3 (2015): 254. http://dx.doi.org/10.22621/cfn.v129i3.1724.

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The American Pika (Ochotona princeps) is vulnerable to climate change as a result of its dependence on cool, moist conditions. Most research on climatic determinants of American Pika distribution has been done in the United States where conditions are different from those in the higher-latitude pika ranges of the Canadian Rockies. I examined recent (1980–2009) and future (2050s and 2080s) average and maximum mean summer temperatures for 114 current American Pika locations in Alberta to assess whether future conditions are likely to place these animals at risk. At all current sites, mean summer

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Pang, Xiao Pan, and Zheng Gang Guo. "Plateau pika disturbances alter plant productivity and soil nutrients in alpine meadows of the Qinghai-Tibetan Plateau, China." Rangeland Journal 39, no. 2 (2017): 133. http://dx.doi.org/10.1071/rj16093.

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Plateau pika (Ochotona curzoniae) is an endemic mammal in the Qinghai-Tibetan Plateau, and its activities create extensive disturbances on vegetation and soil of alpine meadow. Field surveys at two sites were conducted to determine the effects of plateau pika disturbances on important soil factors and plant biomass of vegetated land, and their relationships of the same alpine meadow type. Our study showed that plateau pika disturbances significantly increased soil organic carbon, soil total nitrogen, graminoid biomass and the number of plant species, and significantly decreased soil moisture a

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Pataer, Apar. "Target Misfolded Protein Clearance Pathway for Cancer Therapy." Proceedings 40, no. 1 (2020): 45. http://dx.doi.org/10.3390/proceedings2019040045.

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The role of RNA-dependent protein kinase R (PKR) and its association with misfolded protein expression in cancer cells are unclear. Herein we report that PKR regulates misfolded protein clearance by preventing it release through exosomes and promoting lysosomal degradation of misfolded prion proteins in cancer cells. We demonstrated that PKR contributes to the lysosome function and regulates misfolded prion protein clearance. We hypothesized that PKR-associated lysosome function is critical for cancer but not normal cell survival, representing an effective approach for highly targeted cancer t

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