Academic literature on the topic 'Picropodophylline'

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Journal articles on the topic "Picropodophylline"

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Roulland, Emmanuel, Emmanuel Bertounesque, Christiane Huel, and Claude Monneret. "Synthesis of picropodophyllin homolactone." Tetrahedron Letters 41, no. 35 (2000): 6769–73. http://dx.doi.org/10.1016/s0040-4039(00)01136-9.

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Roulland, Emmanuel, Emmanuel Bertounesque, Christiane Huel, and Claude Monneret. "ChemInform Abstract: Synthesis of Picropodophyllin Homolactone." ChemInform 31, no. 45 (2000): no. http://dx.doi.org/10.1002/chin.200045231.

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Wen, Pu Hong. "Kinetic Investigation of Thermal Decomposition Reactions of Podophyllic Acid and Picropodophyllic Acid." Advanced Materials Research 391-392 (December 2011): 1230–34. http://dx.doi.org/10.4028/www.scientific.net/amr.391-392.1230.

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The thermal behavior and thermal decomposition kinetic parameters of podophyllic acid and picropodophyllic acid in a temperature-programmed mode have been investigated by means of DSC and TG-DTG. The kinetic model functions in differential and integral forms of the thermal decomposition reactions mentioned above for leading stage were established. The kinetic parameters of the apparent activation energy Ea and per-exponential factor A were obtained from analysis of the TG-DTG curves by integral and differential methods. The most probable kinetic model function of the decomposition reaction in
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Guo, Hong Zhu, De An Guo, Xue Yan Fei, Ya Jun Cui, and Jun Hua Zheng. "Biotransformation of Podophyllotoxin to Picropodophyllin by Microbes." Journal of Asian Natural Products Research 1, no. 2 (1998): 99–102. http://dx.doi.org/10.1080/10286029808039850.

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Ohshima-Hosoyama, Sachiko, Tohru Hosoyama, Laura D. Nelon, and Charles Keller. "IGF-1 receptor inhibition by picropodophyllin in medulloblastoma." Biochemical and Biophysical Research Communications 399, no. 4 (2010): 727–32. http://dx.doi.org/10.1016/j.bbrc.2010.08.009.

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Wu, Qi, Ai-Ling Tian, Guido Kroemer, and Oliver Kepp. "Autophagy induction by IGF1R inhibition with picropodophyllin and linsitinib." Autophagy 17, no. 8 (2021): 2046–47. http://dx.doi.org/10.1080/15548627.2021.1936934.

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Berkowitz, David B., Sungjo Choi, and Jun-Ho Maeng. "Enzyme-Assisted Asymmetric Total Synthesis of (−)-Podophyllotoxin and (−)-Picropodophyllin." Journal of Organic Chemistry 65, no. 3 (2000): 847–60. http://dx.doi.org/10.1021/jo991582+.

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Pohmakotr, Manat, Taweechote Komutkul, Patoomratana Tuchinda, Samrarn Prabpai, Palangpon Kongsaeree, and Vichai Reutrakul. "Syntheses of (±)-thuriferic acid ethyl ester, its analogues and (±)-picropodophyllone." Tetrahedron 61, no. 22 (2005): 5311–21. http://dx.doi.org/10.1016/j.tet.2005.03.069.

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Pullin, Robert D. C., Jonathan D. Sellars, and Patrick G. Steel. "Silenes in organic synthesis: a concise synthesis of (±)-epi-picropodophyllin." Organic & Biomolecular Chemistry 5, no. 19 (2007): 3201. http://dx.doi.org/10.1039/b710370k.

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Colón, Eugenia, Farasat Zaman, Magnus Axelson, et al. "Insulin-Like Growth Factor-I Is an Important Antiapoptotic Factor for Rat Leydig Cells during Postnatal Development." Endocrinology 148, no. 1 (2007): 128–39. http://dx.doi.org/10.1210/en.2006-0835.

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The present investigation examines the influence of IGF-I and the role of IGF-I receptor (IGF-IR) in the apoptosis/survival of Leydig cells. Immunohistochemical analysis of the rat testis at different ages revealed that the level of the phosphorylated IGF-IR increases from birth to d 20 of postnatal life, remaining high in the adult testis. Western blotting revealed that this level is higher in Leydig cells isolated from 40-d-old than from 10- or 60-d-old rats. Application of the terminal deoxyribonucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling assay revealed that
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Dissertations / Theses on the topic "Picropodophylline"

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Tian, Ailing. "IGF1 Receptor Inhibition Amplifies the Effects of Cancer Drugs by Autophagy and Immune-Dependent Mechanisms." Electronic Thesis or Diss., université Paris-Saclay, 2022. http://www.theses.fr/2022UPASL040.

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Un certain nombre de produits végétaux naturels induisent l'autophagie et interviennent sur la durée de vie et la durée de vie dépendantes de l'autophagie dans des modèles de souris appropriés. Ici, nous avons identifié la picropodophylline (PPP) comme un inducteur non toxique du flux autophagique qui agit sur les cellules humaines et de souris in vitro, ainsi que sur les organes de souris in vivo. Mécaniquement, PPP inhibe IGF1R ainsi qu'en aval d'AKT, la cible mécaniste du complexe de rapamycine 1 (mTORC1), couplé à l'activation des facteurs de transcription pro-autophagiques EB (TFEB) et E3
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Zhao, Rathje Li-Sophie. "Tropomyosin in Normal and Malignant Cells and the Action of Picropodophyllin on the Microfilament and Microtubule Systems." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-27767.

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Cell motility is a fundamental process, enabling cells to migrate, for instance during embryogenesis, tissue repair and defense. Force is generated by two protein systems, which also participate in cell proliferation, control macromolecular and organelle distribution and determine the fine structure of the cell interior. The major components of these are actin and tubulin, respectively, and they are referred to as the microfilament and the microtubule systems. This thesis focuses on tropomyosin, one of many microfilament associated proteins coupled to actin dynamics and organization and expres
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Larsson, Patrik. "Inhibiting the IGF-1 receptor with the cyclolignan Picropodophyllin: an in vitro study of ovulation, implantation and receptivity in a mouse model." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-89109.

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<p>Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice
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Delforoush, Maryam. "Potential New Drugs in Lymphoma." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-280546.

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Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). Many patients with lymphomas can be successfully treated however patients who relapse or are refractory have a poor prognosis, warranting further investigations to identify potential targets and develop novel drugs. Picropodophyllin (PPP), a potent and selective inhibitor of IGF-1R, inhibits malignant cell growth with low or no toxicity on normal
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Conference papers on the topic "Picropodophylline"

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Wong Te Fong, Anne-Christine LF, Chris Jones, John R. Griffiths, Martin O. Leach, and Yuen-Li Chung. "Abstract 5640: Picropodophyllin downregulates p53 and increases the Warburg effect in pediatric glioblastoma cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5640.

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