Dissertations / Theses on the topic 'PID control action'

Made available in DSpace on 2014-06-11T19:27:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-08-11Bitstream added on 2014-06-13T18:55:43Z : No. of bitstreams: 1 guirao_phf_me_ilha.pdf: 1687835 bytes, checksum: 03fd61b5a3923d210d53985b49bab6bd (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Neste trabalho apresenta-se uma análise teórica do desempenho de um sistema de controle ativo de vibrações de rotores utilizando mancais magnéticos. Trata-se de uma alternativa de controle ativo de vibrações de rotores onde um sistema adaptativo feedforward é empregado sobreposto ao sistema de controle feedback dos mancais magnéticos. O desempenho de algumas arquiteturas de controle, tanto em termos de vibração global como em vibração local do rotor, foi analisado dando ênfase na variação do ganho proporcional e derivativo do controlador PID, que compõe o circuito de controle do mancal magnético ativo. Também foi analisado o efeito da posição e do número de sensores de erro, bem como o efeito do mancal atuador utilizado, sobre o desempenho das estratégias de controle. O sistema de controle foi aplicado em um modelo teórico de rotor desenvolvido pelo método da matriz de impedância.<br>In this work a theoretical analysis of the performance of a system which actively controls vibrations of rotors using magnetic bearings is presented. The proposed system of control is an alternative of active control of rotor vibrations in which an adaptive feedforward system superimposed on the feedback control system of the magnetic bearings is used. The performance of some control architectures was analyzed, in terms of global vibration as in terms of local vibration of the rotor, giving emphasis in the variation of the proportional and derivative gain of the PID controller of the control circuit of the active magnetic bearings. Furthermore, the performance of the vibration control system was analyzed considering the effect of the number and position of the error sensors, as well as the effect of the magnetic bearing employed as actuator. The control system was applied in a theoretical rotor model developed by the matrix impedance method.

Orientador: Luiz de Paula do Nascimento<br>Banca: João Antonio Pereira<br>Banca: Kátia Luchese Cavalca Dedini<br>Resumo: Neste trabalho apresenta-se uma análise teórica do desempenho de um sistema de controle ativo de vibrações de rotores utilizando mancais magnéticos. Trata-se de uma alternativa de controle ativo de vibrações de rotores onde um sistema adaptativo "feedforward" é empregado sobreposto ao sistema de controle "feedback" dos mancais magnéticos. O desempenho de algumas arquiteturas de controle, tanto em termos de vibração global como em vibração local do rotor, foi analisado dando ênfase na variação do ganho proporcional e derivativo do controlador PID, que compõe o circuito de controle do mancal magnético ativo. Também foi analisado o efeito da posição e do número de sensores de erro, bem como o efeito do mancal atuador utilizado, sobre o desempenho das estratégias de controle. O sistema de controle foi aplicado em um modelo teórico de rotor desenvolvido pelo método da matriz de impedância.<br>Abstract: In this work a theoretical analysis of the performance of a system which actively controls vibrations of rotors using magnetic bearings is presented. The proposed system of control is an alternative of active control of rotor vibrations in which an adaptive feedforward system superimposed on the feedback control system of the magnetic bearings is used. The performance of some control architectures was analyzed, in terms of global vibration as in terms of local vibration of the rotor, giving emphasis in the variation of the proportional and derivative gain of the PID controller of the control circuit of the active magnetic bearings. Furthermore, the performance of the vibration control system was analyzed considering the effect of the number and position of the error sensors, as well as the effect of the magnetic bearing employed as actuator. The control system was applied in a theoretical rotor model developed by the matrix impedance method.<br>Mestre

A utilização de sistemas de controle para estabilidade de conjuntos de barras para pulverizadores agrícolas é uma tendência devida principalmente aos problemas ambientais e de custo. Neste trabalho, o comportamento dinâmico de um pulverizador de arrasto é analisado através de um modelo não linear, obtido através de técnicas de modelagem de sistemas multicorpos utilizando-se o programa ADAMS. Foram utilizadas duas estratégias de controle PID e \"fuzzy\" a partir de medidas obtidas com fusão de sensores. A estratégia de controle clássica PID foi desenvolvida e implementada no modelo não linear no ADAMS através de ferramentas internas existentes no programa. Já a estratégia \"fuzzy\" foi desenvolvida e implementada no modelo não linear no ADAMS através da técnica de co-simulação ADAMS/Matlab. O comportamento dos sistemas de controle foi investigado através de simulação computacional. Foram testados alguns tipos de entradas (entrada degrau, entrada harmônica, entrada randômica e entrada randômica com descontinuidades bruscas). Em todas as simulações os resultados obtidos com os sistemas de controles ativos mostraram melhor estabilidade do conjunto de barras. Entre as leis de controle implementadas (PID e \"fuzzy\") não houve grandes diferenças entre as oscilações da barra exceto na entrada do tipo randômica com descontinuidades bruscas. Neste caso a lei de controle \"fuzzy\" apresentou uma grande melhoria com boa atenuação das oscilações do conjunto de barras quando comparadas com a aplicação do sistema de controle PID.<br>The use of active control systems for stability of booms in agricultural sprayers trend is mainly due to the environmental and costs question. In this work, the dynamic behavior of a trailed sprayer is analyzed using a nonlinear model, obtained through techniques of modeling multibody systems using the ADAMS. It is used two active control strategies, PID classical control and fuzzy, with measured data from sensor fusion. The classical PID control strategy was developed and implemented in a nonlinear model on ADAMS software using existing tools built into the program. Fuzzy was another strategy developed and implemented in the nonlinear model on ADAMS software using a technique of co-simulation ADAMS/Matlab. The behavior of control systems was investigated through computer simulation. It was tested some types of inputs (step input, harmonic input, random input and random input with abrupt discontinuities). All simulations data obtained from the applications of active systems showed better stability for boom assembly. Among the implemented two active control laws (PID and \"fuzzy\") there were no significant differences between the oscillations attenuation of the boom, except with the random input with abrupt discontinuities. wherein this case the application of the active control \"fuzzy\" strategy developed better stability on boom than the application of PID control.

This thesis asks the research question In what ways do gender stereotypes inform the thoughts and actions of CCTV control room operators? Initially inspired by the problem of women’s lesser criminality, this research employs a police Closed Circuit Television (CCTV) control room ethnography to enable an exploration of the ways in which CCTV operators construct and interpret crime/deviance and sex/gender and what gender stereotypes they use to make sense of what they see on their screens. The fieldwork undertaken produces a social phenomenology of CCTV operators’ perceptions of potential crime/deviance, how these are gendered and their effects on surveillance practices. A framework for data analysis was iteratively developed. The themes it covers are: biological essentialism, social constructionism and the everyday reconciliation of theoretical problems through pragmatic solutions in the lived experience. These conceptual frames, drawn from criminological and gender theory, usefully allow the rethinking of gendered criminality/deviance and integral stereotyping. The interpretation of research findings using this framework indicates that operators' decision making is heavily based on stereotypes of sex/gender that are constructed through, and help to construct, corresponding incidences of crime/deviance, as well as a CCTV control room workplace culture. More specifically, the findings suggest that there are significant co-dependencies and co- productions of crime/deviance and sex/gender, which result in corresponding concepts and practices, and thus affinities between lay and academic theorising. These conclusions point to a need for further examination of the important consequences of assumptions contained in socially constructed stereotypes of sex/gender, especially in the context of social processes pertaining to crime/deviance, and their academic analysis and representation.

Le comportement dynamique des turbomachines industrielles doit respecter des critères émis par les normes internationales et les utilisateurs. Les rotors flexibles sont sensibles à la distribution de balourd, et sont soumis aux excitations aérodynamiques de leur environnement. Usuellement, les contrôleurs utilisés peinent à délivrer le niveau d’exigence demandé, par conséquent les propriétés mécaniques des paliers magnétiques sont fortement dépendantes de celles des rotors. L’objectif de ce mémoire est d’analyser le comportement dynamique des compresseurs centrifuges afin de proposer une stratégie de contrôle innovante. D’abord, chaque palier est considéré comme une entité a part entière en couplant ses deux axes d’action. Le comportement dynamique du rotor est exprimé dans le repère polaire. Par ailleurs, la logique floue, qui utilise un modèle de pensée proche du raisonnement humain, applique des actions correctives en fonction du comportement dynamique global du rotor. Ainsi, l’utilisation couplée de ces deux approches créé une synergie permettant d’agir sur le système de manière ciblée. Le contrôleur dissipe l’énergie cinétique du rotor lors du franchissement de vitesses critiques afin d’atténuer la réponse au balourd, ou augmente la raideur du palier lors de vibrations transitoires ou asynchrones afin de réduire la trajectoire du rotor. Le faible amortissement structurel du rotor le rend sensible au phénomène de « spillover » (l’énergie de contrôle affecte les modes de fréquence élevée). Or, la logique floue ne peut pas gérer ce phénomène. Ainsi, un contrôleur PID sous-jacent est utilisé pour maîtriser la stabilité des modes hautes fréquences. Au final, le contrôleur flou polaire permet d’obtenir des marges de performances entre les capacités de cet asservissement et le cahier des charges. Ces marges sont utilisées pour trois objectifs : le respect des spécifications, l’amélioration du comportement subsynchrone, et enfin la simplification et la standardisation du contrôleur sous-jacent nommé ici SPID. Ce contrôleur est tel que ses caractéristiques, dans la plage de fréquence utile, sont indépendantes du rotor pour une application donnée. Enfin, la stratégie développée est évaluée avec des simulations numériques et des essais expérimentaux. D’abord, le modèle numérique est validé, puis le contrôleur est appliqué à un banc d’essais académique. Le comportement est stable et robuste. Il présente des performances supérieures au PID augmenté fourni avec le banc, que ce soit pour la réponse au balourd, ou pour la réponse à des excitations subsynchrones. Finalement, la démarche est appliquée à un compresseur industriel. Les simulations montrent que le comportement est proche de celui exigé pour des machines sur paliers classiques. L’optimisation de l’approche et l’automatisation de la conception pourraient conduire à la standardisation des paliers magnétiques actifs<br>The dynamic behaviour of large turbomachinery should satisfy stringent requirements dictated by international standards and final users. Their flexible rotor is sensitive to the unbalance distribution and subjected to particular excitations coming from the industrial process. Usually, the performance margins between the requirements and the classical controller capabilities are small. Consequently, the magnetic bearing characteristics depend on the rotor geometry. Designing such controllers is difficult and time consuming. The objective of this thesis is to investigate the dynamic behaviour of supercritical centrifugal compressors in order to propose a new control strategy. First, each bearing is considered as one entity by coupling its two axes of action. The introduction of polar quantities permits a better observation of the rotor dynamic behaviour. In addition, by using logic close to human being reasoning, the fuzzy logic modulates the action forces as a function of the global dynamic behaviour. The coupling of the two approaches is an efficient way to apply targeted corrective actions. This controller attenuates the unbalance vibration when crossing critical speeds by applying damping forces, or increases the stiffness during transient or asynchronous excitations in order to limit the maximum displacement reached. As their structural damping is low, flexible rotors are very sensitive to spillover effect, which cannot be managed by fuzzy controllers. Consequently, an underlying PID is necessary. This hand-synthesized controller has high frequency characteristics tuned in order to ensure stability and robustness for each rotor. Compared to a classical approach, the polar fuzzy controller enables to increase the performance margins. These margins are used to fulfil three objectives: the achievement of standards requirements, the improvement of the subsynchronous behaviour, and the simplification and the standardization of the PID controller that we called SPID. This SPID is designed for a given application, such that the bearing characteristics on the operating frequency range are always the same. The control strategy is assessed numerically and experimentally. First, the numerical model is validated with experimental tests. Then, the controller developed is applied to an academic test rig. The controller is stable and robust. It exhibits performance superior to the augmented PID supplied with the test rig for both unbalance response and response to subsynchronous excitations. Finally, the control of an industrial compressor is assessed numerically. The results obtained are close to the standards requirements used for classical bearings. The optimization of the approach and the utilization of an automatic tuning algorithm for high frequency characteristics could lead to the standardization of Active Magnetic Bearings

Active safety systems for road vehicles have been improved considerably in recent years along with technological advances and the increasing demand for road safety. In the development route of active safety systems which started with introduction of digital controlled ABS in the late seventies, vehicle stability control systems have been developed which today, with an integration approach, incorporate ABS and other previously developed active safety technologies. ABS, as a main part of this new structure, still maintains its importance. In this thesis, a design methodology of an antilock braking system controller for four wheeled road vehicles is presented with a detailed simulation work. In the study, it is intended to follow a flexible approach for integration with unified control structure of an integrated active safety system. The objective of the ABS controller, as in the previous designs in literature, is basically to provide retention of vehicle directional control capability and if possible shorter braking distances by controlling the wheel slip during braking. iv A hierarchical structure was adopted for the ABS controller design. A high-level controller, through vehicle longitudinal acceleration based estimation, determines reference slip values and a low-level controller attempts to track these reference slip signals by modulating braking torques. Two control alternatives were offered for the design of the low-level controller: Fuzzy Logic Control and PID Control. Performance of the ABS controller was analyzed through extensive simulations conducted in MATLAB/Simulink for different road conditions and steering maneuvers. For simulations, an 8 DOF vehicle model was constructed with nonlinear tires.

La violenza contro le donne costituisce un problema a livello mondiale. 1 donna su 3, in tutto il mondo, subisce violenza fisica e/o sessuale da parte del partner (WHO, 2013). 2 milioni di persone si trovano in condizioni di grave povertà (Istat, 2016).Questi fattori possono incidere anche sulla sfera della genitorialità, in particolare intaccando la capacità di promuovere e supportare lo sviluppo fisico, emotivo, sociale, economico ed intellettuale del proprio figlio (Bornstein M.H., 19919. Diversi studi mostrano come specifiche caratteristiche di queste esperienze siano associate a conseguenze psicologiche e come la gravità e la cronicità degli atti di violenza subiti mostrino un legame con distress psicologico, vissuti di ansia, depressione, PTSD e altri sintomi (Dutton, 1992; Ahlfs-Dunn S.M.,2016). Gli scopi di questa ricerca sono quindi valutare l’impatto psicologico della violenza sulle donne in condizioni di povertà, sulla dimensione della genitorialità e sugli operatori che lavorano nell’ambito dell’assistenza socio-sanitaria. Lo studio si è svolto al Centro del San Fedele di Milano, un’organizzazione che riserva particolare attenzione all’accompagnamento sociale e all’educazione sanitaria .Sono state costruite ad hoc due batterie testali., costituite da una scheda anagrafica; il General Health Questionnaire (GHQ-12), (Piccinelli et al., 1993); il Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM); il Parenting Stress Index (PSI-SF) (Guarino, 2008). La batteria per gli operatori comprende una scheda anagrafica; il Maslach Burnout Inventory (MBI) (Maslach & Jackson, 1981), il Coping Inventory for Stressful Situations (CISS-2) (Endler & Parker, 1990), il Balanced Emotional Empathy Scale (BEES). Il campione è compost da 150 donne (età media: 44,92; d.s.=± 13,93) . Il 58,7% è stata vittima di un qualche tipo di violenza. Le persone che hanno subito un qualche tipo di violenza hanno riportato livelli significativamente peggiori di Benessere (t=-2,13;p=,035), Sintomi (t=-2,36;p=,02), Funzionamento (t=-2,92;p=,004), Rischio (t=-2,68;p=,008) e Distress Totale (t=-2,96;p=,004) rispetto a chi non ha sperimentato alcun tipo di violenza. Inoltre, le vittime di violenza fisica o psicologica hanno riportato livelli significativamente peggiori in tutte le sottoscale del questionario CORE-OM e peggiori livelli di salute generale. La provenienza geografica non è invece risultata influenzare nessuna delle variabili indagate (p>,05). Su 150 donne 108 sono madri (età media: 39,90; d.s.=± 11,35). In un’ottica preventiva, è stato scelto di testare solo le madri di bambini sotto gli 11 anni. Le donne che hanno subito violenza riportano maggiore compromissione del Funzionamento (t(138)=-2,37;p=,02) e CORE-Totale (t(138)=-2,16;p=,03). Le vittime di violenza economica hanno riportato un maggiore livello di distress genitoriale, in particolare connesso con la gestione di un bambino difficile (PSI)(t(50)=-2,14; p=,038). Quest’ultima variabile risulta inoltre essere predetta dal livello di GHQ con effetto dell’avere un partner quale variabile moderatrice(F(3;47)=4,199;p=,0103). Il campione degli operatori invece è compost da 22 volontari (D:16; M=6; età media: 55,32; s.d.=16,65), che hanno riportato bassi livelli di Esaurimento Emotivo (m=11,71; d.s.=11,88) e moderati di Depersonalizzazione (m=4,41; d.s.=4,39) e Realizzazione Personale (m=36,48; d.s.=6,98). Uomini e donne non differiscono significativamente rispetto ad alcuna sottoscala. I volontari che lavorano a diretto contatto con gli utenti riportano livelli significativamente più elevati di Esaurimento Emotivo (t=2,235, p<,05) rispetto ai colleghiSecondo diversi autori (Briere, 2004; Krantz & Garcia-Moreno, 2005; Krauss, 2006) lavorare su questi aspetti potrebbe essere rilevante al fine di identificare l'emergere di disagio e fornire interventi di prevenzione.<br>Violence against women is known to be a worldwide emerging issue. In fact, 1 in 3 women throughout the world experience physical violence and/or sexual violence by a partner (WHO, 2013). 2 million women in Italy deal with severe poverty (Istat, 2016) and 6 million deal with physical violence (Istat, 2015).All these factors may also influence parenting, the ability to promote and support physical, emotional, social, economic and intellectual development of a child (Bornstein M.H., 1991) Several studies show that specific characteristics of these experiences are associated with psychological consequences and how the severity and chronicity of suffered violent acts are linked with psychological distress, anxiety, depression, PTSD and other symptoms (Dutton, 1992; Ahlfs-Dunn SM, 2016). In the light of these considerations, it is evident the complexity of the operators’ work in specialized centers that make contact with people who live in these dramatic conditions.Aims of this research are therefore to evaluate the psychological impact of violence on needy women, on the parenting experience and on operators involved in human services. The study takes place at Centro San Fedele in Milan, an organization that have particular attention on social aspects and sanitary education, aimed at hosting, taking care and supporting people who need help. Two series of tests were created ad hoc,composed by a registry paper,General Health Questionnaire (GHQ-12), (Piccinelli et al., 1993); Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM), Parenting Stress Index (PSI-SF) (Guarino, 2008). The series of tests dedicated to operators was composed by a registry paper; Maslach Burnout Inventory (MBI) (Maslach & Jackson, 1981); Coping Inventory for Stressful Situations (CISS-2)(Endler & Parker, 1990), Balanced Emotional Empathy Scale (BEES).The sample is composed by 150 women (mean age: 44.92; s.d.=±13.93). 58,7% has been victim of any type of violence. People who have been victim of any type of violence reported significantly worse levels of Wellbeing (t=-2.13;p=.035), Symptoms (t=-2.36;p=.02), Functioning (t=-2.92;p=.004), Risk (t=-2.68;p=.008), Total Distress (t=-2.96;p=.004) than who didn’t report any type of violence. Furthermore victims of physical or psychological violence reported significantly worse levels of all the subscales of CORE-OM and worse levels of general health. The number of types of violence experienced was significantly correlated with Symptoms (r=.226;p<.01), Risk (r=.254;p<.01), Total Distress (r=.259;p<.01). The geographic origin didn’t significantly influence any variables investigated (p>.05). Out of 150 women 108 are mothers (mean age=39.90; s.d=± 11.35). Women who have been subject to violence have a greater impairment of their functioning (t(138)=-2,37;p=,02)and total CORE (t(138)=-2,16;p=,03). Victims of economic violence reported a greater level of parental distress, particularly connected with the managing of a child (PSI)(t(50)=-2,14; p=,038). The latter variable seems to be foretold by GHQ level with the effect of having a a partner as a moderator variable(F(3;47)=4,199;p=,0103). The sample of operators is composed instead by 22 volunteers (W=16; M=6; mean age=55,32; ds=16,65), who reported low levels of Emotional Exhaustion (m=11.71; s.d.=11.88) and moderate levels of Depersonalization (m=4.41; s. d.=4.39) and Personal Accomplishment (m=36.48;s.d.=6.98). Men and women did not differ significantly on levels of any subscales. Volunteers who has a direct contact with patients reported significantly higher levels of Emotional Exhaustion (t=2.235, p<.05) compared to others . According to different authors (Briere, 2004; Krantz&Garcia-Moreno, 2005; Krauss, 2006) work on these aspects could be relevant in order to identify the emergence of discomfort and provide preventive psychological interventions.

Made available in DSpace on 2014-12-17T14:55:45Z (GMT). No. of bitstreams: 1 RaphaellMS_DISSERT.pdf: 3087457 bytes, checksum: 184208141b97a58de312de245a6bd3e8 (MD5) Previous issue date: 2011-02-11<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Conventional control strategies used in shunt active power filters (SAPF) employs real-time instantaneous harmonic detection schemes which is usually implements with digital filters. This increase the number of current sensors on the filter structure which results in high costs. Furthermore, these detection schemes introduce time delays which can deteriorate the harmonic compensation performance. Differently from the conventional control schemes, this paper proposes a non-standard control strategy which indirectly regulates the phase currents of the power mains. The reference currents of system are generated by the dc-link voltage controller and is based on the active power balance of SAPF system. The reference currents are aligned to the phase angle of the power mains voltage vector which is obtained by using a dq phase locked loop (PLL) system. The current control strategy is implemented by an adaptive pole placement control strategy integrated to a variable structure control scheme (VS?APPC). In the VS?APPC, the internal model principle (IMP) of reference currents is used for achieving the zero steady state tracking error of the power system currents. This forces the phase current of the system mains to be sinusoidal with low harmonics content. Moreover, the current controllers are implemented on the stationary reference frame to avoid transformations to the mains voltage vector reference coordinates. This proposed current control strategy enhance the performance of SAPF with fast transient response and robustness to parametric uncertainties. Experimental results are showing for determining the effectiveness of SAPF proposed control system<br>Resumo: As estrat?gias de controle convencionais de filtros ativos de pot?ncia paralelos (FAPP) empregam esquemas de detec??o de harm?nicos em tempo real, usualmente implementados com filtros digitais. Isso aumenta o n?mero de sensores na estrutura do filtro, o que resulta em altos custos. Al?m disso, esses esquemas de detec??o introduzem atrasos que podem deteriorar o desempenho da compensa??o de harm?nicos. Diferentemente dos esquemas de controle convencionais, este artigo prop?e uma nova estrat?gia de controle que regula indiretamente as correntes de fase da rede el?trica. As correntes de refer?ncia do sistema s?o geradas pelo controle de tens?o do barramento CC e s?o baseadas no balan?o de pot?ncia ativa do sistema FAPP. As correntes de refer?ncia s?o alinhadas com o ?ngulo de fase do vetor tens?o da rede, que ? obtido usando um PLL (Phase Locked Loop). O controle de corrente ? implementado por uma estrat?gia de controle adaptativo por aloca??o de p?los, integrada com um esquema de controle com estrutura vari?vel (VS?APPC). No VS?APPC, o princ?pio do modelo interno (IMP) de refer?ncia ? usado para eliminar o erro em regime permanente das correntes do sistema. Isso for?a as correntes de fase do sistema a serem senoidais e com baixo teor de harm?nicos. Al?m disso, os controladores de corrente s?o implementados no referencial estacion?rio para evitar transforma??es nas coordenadas de refer?ncia do vetor tens?o da rede. Esta estrat?gia de controle de corrente melhora a performance do FAPP com uma resposta transit?ria r?pida e robustez a incertezas param?tricas. Resultados experimentais s?o mostrados para demonstrar a efic?cia do sistema de controle proposto para o FAPP

Les entreprises pharmaceutiques ont progressivement adopté le concept de Process Analytical Technology (PAT) afin de contrôler et d'assurer en temps réel la qualité des produits pharmaceutiques au cours de leur production. Le PAT et un composant central du concept plus général de Quality-by-Design (QbD) promu par les agence régulatrices et visant à construire la qualité des produits via une approche scientifique et la gestion des risques.Une méthode basée sur la spectroscopie proche infrarouge (PIR) a été développée comme un outil du PAT pour contrôler en ligne la cristallisation d'un principe actif pharmaceutique. Au cours du procédé les teneurs en principe actif et en solvant résiduel doivent être déterminées avec précision afin d'atteindre un point d'ensemencement prédéfini. Une méthodologie basée sur les principes du QbD a guidé le développement et la validation de la méthode tout en assurant l'adéquation avec son utilisation prévue. Des modèles basés sur les moindres carrés partiels ont été construits à l'aide d'outils chimiométriques afin de quantifier les 2 analytes d'intérêt. La méthode a été totalement validée conformément aux requis officiels en utilisant les profils d'exactitude. Un suivi du procédé en temps réel a permis de prouver que la méthode correspond à son usage prévu.L'implémentation de cette méthode comme à l'échelle industrielle au lancement de ce nouveau procédé permettra le contrôle automatique de l'étape de cristallisation dans le but d'assurer un niveau de qualité prédéfini de l'API. D'autres avantages sont attendus incluant la réduction du temps du procédé, la suppression d'un échantillonnage difficile et d'analyses hors ligne fastidieuses<br>Pharmaceutical companies are progressively adopting and introducing the Process Analytical Technology (PAT) concept to control and ensure in real-time product quality in development and manufacturing. PAT is a key component of the Quality-by-Design (QbD) framework promoted by the regulatory authorities, aiming the building of product quality based on both a strong scientific background and a quality risk management approach.An analytical method based on near infrared (NIR) spectroscopy was developed as a PAT tool to control on-line an API (active pharmaceutical ingredient) crystallization. During this process the API and residual solvent contents need to be precisely determined to reach a predefined seeding point. An original methodology based on the QbD principles was applied to conduct the development and validation of the NIR method and to ensure that it is fitted for its intended use. Partial least squares (PLS) models were developed and optimized through chemometrics tools in order to quantify the 2 analytes of interest. The method was fully validated according to the official requirements using the accuracy profile approach. Besides, a real-time process monitoring was added to the validation phase to prove and document that the method is fitted for purpose.Implementation of this method as an in-process control at industrial plant from the launch of this new pharmaceutical process will enable automatic control of the crystallization step in order to ensure a predefined quality level of the API. Other valuable benefits are expected such as reduction of the process time, and suppression of a difficult sampling and tedious off-line analyzes

Les entreprises pharmaceutiques ont progressivement adopté le concept de Process Analytical Technology (PAT) afin de contrôler et d'assurer en temps réel la qualité des produits pharmaceutiques au cours de leur production. Le PAT et un composant central du concept plus général de Quality-by-Design (QbD) promu par les agence régulatrices et visant à construire la qualité des produits via une approche scientifique et la gestion des risques.Une méthode basée sur la spectroscopie proche infrarouge (PIR) a été développée comme un outil du PAT pour contrôler en ligne la cristallisation d'un principe actif pharmaceutique. Au cours du procédé les teneurs en principe actif et en solvant résiduel doivent être déterminées avec précision afin d'atteindre un point d'ensemencement prédéfini. Une méthodologie basée sur les principes du QbD a guidé le développement et la validation de la méthode tout en assurant l'adéquation avec son utilisation prévue. Des modèles basés sur les moindres carrés partiels ont été construits à l'aide d'outils chimiométriques afin de quantifier les 2 analytes d'intérêt. La méthode a été totalement validée conformément aux requis officiels en utilisant les profils d'exactitude. Un suivi du procédé en temps réel a permis de prouver que la méthode correspond à son usage prévu.L'implémentation de cette méthode comme à l'échelle industrielle au lancement de ce nouveau procédé permettra le contrôle automatique de l'étape de cristallisation dans le but d'assurer un niveau de qualité prédéfini de l'API. D'autres avantages sont attendus incluant la réduction du temps du procédé, la suppression d'un échantillonnage difficile et d'analyses hors ligne fastidieuses<br>Pharmaceutical companies are progressively adopting and introducing the Process Analytical Technology (PAT) concept to control and ensure in real-time product quality in development and manufacturing. PAT is a key component of the Quality-by-Design (QbD) framework promoted by the regulatory authorities, aiming the building of product quality based on both a strong scientific background and a quality risk management approach.An analytical method based on near infrared (NIR) spectroscopy was developed as a PAT tool to control on-line an API (active pharmaceutical ingredient) crystallization. During this process the API and residual solvent contents need to be precisely determined to reach a predefined seeding point. An original methodology based on the QbD principles was applied to conduct the development and validation of the NIR method and to ensure that it is fitted for its intended use. Partial least squares (PLS) models were developed and optimized through chemometrics tools in order to quantify the 2 analytes of interest. The method was fully validated according to the official requirements using the accuracy profile approach. Besides, a real-time process monitoring was added to the validation phase to prove and document that the method is fitted for purpose.Implementation of this method as an in-process control at industrial plant from the launch of this new pharmaceutical process will enable automatic control of the crystallization step in order to ensure a predefined quality level of the API. Other valuable benefits are expected such as reduction of the process time, and suppression of a difficult sampling and tedious off-line analyzes

Thesis (M. Sc.)--University of Alberta, 2009.<br>Title from pdf file main screen (viewed on Dec. 10, 2009). "A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Chemical Engineering, Department of Chemical and Materials Engineering, University of Alberta." Includes bibliographical references.

Η παρούσα διδακτορική διατριβή αναφέρεται σε έδρανα ολίσθησης. Συγκεκριμένα, αναφέρεται στο σχεδιασμό και την κατασκευή ενός νέου, πρωτότυπου υβριδικού εδράνου ολίσθησης, το οποίο έχει τη δυνατότητα να λειτουργεί είτε ως υδροδυναμικό, είτε ως ενεργό ηλεκτρομαγνητικό, είτε ως υβριδικό, δηλαδή υδροδυναμικό και ενεργό ηλεκτρομαγνητικό ταυτόχρονα. Προκειμένου να πραγματοποιηθεί ο σχεδιασμός και η κατασκευή του συγκεκριμένου υβριδικού εδράνου ολίσθησης, έγιναν υπολογισμοί και προσομοίωση του υδροδυναμικού πεδίου για τα υδροδυναμικά έδρανα ολίσθησης και του ηλεκτρομαγνητικού πεδίου για τα ηλεκτρομαγνητικά έδρανα στο πρόγραμμα ANSYS. Η προσομοίωση των υβριδικών εδράνων ολίσθησης έγινε με επαναληπτική διαδικασία μεταξύ του υδροδυναμικού και του ηλεκτρομαγνητικού πεδίου προκειμένου να υπολογίζεται το κάθε επιθυμητό μέγεθος. Για το σχεδιασμό του υβριδικού εδράνου ολίσθησης χρησιμοποιήθηκε το σχεδιαστικό πρόγραμμα CATIA. Για την προσομοίωση του ελέγχου του υβριδικού εδράνου ολίσθησης, χρησιμοποιήθηκε το πρόγραμμα Matlab, το οποίο ενεργοποιεί το πρόγραμμα Ansys για τον υπολογισμό των χαρακτηριστικών του υδροδυναμικού και του ηλεκτρομαγνητικού πεδίου του εδράνου και το Simulink module του Matlab για τον υπολογισμό των χαρακτηριστικών του ελέγχου, ώστε να γίνονται όλοι οι απαραίτητοι υπολογισμοί αυτοματοποιημένα. Τέλος, έγιναν υπολογισμοί και προσομοίωση δυναμικής περιστρεφόμενων αξόνων, με στήριξη του ρότορα σε δύο έδρανα και δίσκο προσαρμοσμένο στον ρότορα, στο πρόγραμμα Matlab, με σύνδεση με το Ansys για τον υπολογισμό των συντελεστών ελαστικότητας και απόσβεσης και το Simulink module του Matlab για τον υπολογισμό των χαρακτηριστικών του ελέγχου, με σκοπό την ολοκληρωμένη ανάλυση του συστήματος. Συμπερασματικά, μέσω της συγκεκριμένης διδακτορικής διατριβής αποδεικνύεται πως ο σχεδιασμός, η λειτουργία και η κατασκευή του συγκεκριμένου πρωτότυπου υβριδικού εδράνου ολίσθησης είναι εφικτά, και από τα αποτελέσματα προκύπτει πως η λειτουργία ενός τέτοιου υβριδικού εδράνου ολίσθησης, έχει πολλά πλεονεκτήματα σε σχέση με άλλα έδρανα στήριξης περιστρεφόμενων αξόνων, είτε αυτά είναι απλά είτε υβριδικά και μπορεί να εφαρμοστεί είτε σε εργαστηριακό επίπεδο είτε σε βιομηχανικές εφαρμογές.<br>The present doctoral thesis refers to hydrodynamic journal bearings. Specifically, it refers to the design and construction of a new, innovative hybrid journal bearing, which has the ability to function either as hydrodynamic or active magnetic or hybrid, i.e. both hydrodynamic and active magnetic, at the same time. In order to be performed the design and construction of the specific hybrid journal bearing, calculations and simulation of the hydrodynamic field for the hydrodynamic journal bearings in the program ANSYS, have been made. The simulation of the hybrid journal bearings has been made with iterative process, between the hydrodynamic and active magnetic field, so that every desired magnitude can be calculated. For the design of the hybrid journal bearing, the designing program CATIA has been used. For the simulation of the control of the hybrid journal bearing, the program Maltab has been used, which activates the program Ansys, for the calculation of the features of the hydrodynamic and active magnetic field of the bearing and the Simulink module of Maltab, for the calculation of the features of control, so that all necessary calculations can be made automated. Finally, calculations and simulation of rotor dynamics, with support of the rotor in two bearings and disc adjusted to the rotor, in Maltab, in connection to Ansys, for the calculation of the elastic and damping coefficients and the Simulink module of Maltab, for the calculation of the features of control, have been made, having as a purpose the complete analysis of the system. In conclusion, through the specific doctoral thesis, it is proved that the design, function and construction of the specific, new hybrid journal bearing, can be achieved and the results show that the function of such a hybrid journal bearing, has many advantages compared to other bearings of support of rotors, either they are simple or hybrid and it can be applied either to laboratory level or industrial applications.

Thesis (M.S.)--State University of New York at Buffalo, 2005.<br>Title from PDF title page (viewed on May. 03, 2006) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Drury, Collin G. Includes bibliographical references.

Thesis (M.A.)--State University of New York at Buffalo, 2006.<br>Title from PDF title page (viewed on Oct. 04, 2006) Available through UMI ProQuest Digital Dissertations. Thesis adviser: St. Jean, Peter K. B. Includes bibliographical references.