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Relevant bibliographies by topics / PIK3

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Dissertations / Theses

Academic literature on the topic 'PIK3'

Author: Grafiati

Published: 4 June 2021

Last updated: 12 February 2022

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Dissertations / Theses on the topic "PIK3"

1

Mordant, Pierre. "Cancer bronchique primitif, voies de signalisation intra-cellulaires et modèles précliniques." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00809668.

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Contexte. Le cancer bronchopulmonaire (CBP) demeure la première cause de mortalité par cancer dans le monde. Malgré l'espoir suscité par le développement des thérapies ciblées, son pronostic demeure sombre, particulièrement dans les cas de CBP à petites cellules (CBP-PC) et de CBP non à petites cellules (CBP-NPC) présentant une activation de l'oncogène KRAS. Matériel et Méthodes. Nous avons mené 3 études successives, visant à (i) radiosensibiliser des modèles de CBP-PC par l'ajout d'un inhibiteur de BCL2, (ii) cibler des modèles de CBP-NPC mutés KRAS par l'association d'un inhibiteur de mTOR e

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2

Kielkowska, Anna Jadwiga. "The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273823.

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Name: Anna Jadwiga Kielkowska Dissertation title: The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular growth, survival and metabolism. Once activated by environmental stimuli such as growth factors, cytokines or antigens, they exert their catalytic activity by phosphorylating phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) to yield a second messenger - PI(3,4,5)P3. Unrestrained PI

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3

Valet, Colin. "Rôles de la PI3 kinase de classe II alpha et de la PI3K de classe III, vps34, dans la production et les fonctions plaquettaires." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30032.

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Les mégacaryocytes sont des cellules de la moelle osseuse qui par un processus complexe et encore mal caractérisé, mégacaryopoïèse/thrombopoïèse, donnent naissance, in fine, aux plaquettes sanguines. La différenciation mégacaryocytaire nécessite un intense remodelage nucléaire et cytoplasmique, guidé à la fois par des facteurs intrinsèques mais aussi par des facteurs extrinsèques tel que le microenvironnement médullaire. Les plaquettes sanguines sont des acteurs essentiels du maintien de l'intégrité vasculaire. Elles sont les premiers éléments cellulaires à intervenir dans l'arrêt du saignemen

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4

Stoor, Per. "Pika Pika? Pikachu! : En kvalitativ spelanalys av de socialt uppmuntrande designelementen i Pokemon Go." Thesis, Umeå universitet, Institutionen för informatik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130591.

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This paper is about how the location based game Pokemon Go motivates players to play the game outdoors and defining the games design principles and how they encourage social interaction between players. The paper has made use of three different qualitative data gathering methods, a brief ethnographical field study, semi structured interviews and an analysis based on theoretical frameworks used for conducting research about video games. Players were found to play outside for three reasons, the freedom of using a smartphone to play location based games, Pokemon Go’s location based game technolog

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5

Balakrishnan, Sanjeevi. "Establishing a biological role for class II phosphoinositide 3-kinase (PI3K) enzyme PI3K-C2??" Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39135.

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Phosphoinositide 3-Kinase (PI3K) enzymes control a variety of cellular processes and their deregulation has been extensively investigated in disease conditions including renal disease, autoimmunity and chronic inflammation. Whilst PI3K enzymes have been the subject of intense research activity, the precise biological role of PI3K-C2?? enzyme remains unclear. PI3K-C2??-/- mice developed focal segmental glomerulosclerosis, damaging podocyte morphology and affecting function. My thesis explored the contribution of the PI3K-C2?? enzyme in the pathology of chronic diseases. PI3K-C2??flx/+ mice were

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6

Kumph, John Muir. "Maneuvering of a robotic pike." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/8968.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.<br>Includes bibliographical references (p. 75-76).<br>A robotic mechanism is described, called Robopike. The robot has fork length equal to 82cm, and contains 5 motors, a computer and a wireless modem for communication during testing. Details of the construction and testing methods are provided. The testing covered only a small part of the extensive parametric range, and resulted in speeds up to 0.11 body lengths per second

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7

Hale, Benjamin G. "Influenza A viruses and PI3K signalling." Thesis, University of St Andrews, 2007. http://hdl.handle.net/10023/483.

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The influenza A virus non-structural (NS1) protein is multifunctional, and during virus-infection NS1 interacts with several factors in order to manipulate host-cell processes. This study reports that NS1 binds directly to p85β, a regulatory subunit of phosphoinositide 3-kinase (PI3K), but not to the related p85α. Expression of NS1 was sufficient to activate PI3K and cause the phosphorylation of a downstream mediator of PI3K signalling, Akt. However, in virus-infected MDCK cells, the kinetics of Akt phosphorylation did not correlate with NS1 expression, and suggested that negative regulation o

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8

Hale, Benjamin G. "Influenza A viruses and PI3K signalling /." St Andrews, 2008. http://hdl.handle.net/10023/483.

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9

Engstedt, Olof. "Anadromous Pike in the Baltic Sea." Doctoral thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-13856.

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The pike (Esox lucius) is a major predator and top-down regulator in the Baltic Sea where it exists in two sympatric forms. One spawn in streams and rivers and the other one spawn in the sea. During the last decades, the habitats for both of these forms have developed in a negative way. In some freshwater systems, up to 90 % of the water areas have disappeared, mainly through drainage and straightening of watercourses for agricultural purposes. In the sea, reproduction habitats decrease due to construction of harbours and human activities that create disturbances. The perhaps largest single fa

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10

White, Angela R. "Shared PI3K signaling abnormalities in brain tumors and epilepsy: PI3K inhibition in PTEN-deficient disorders of the brain." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1603712831970142.

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