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Dissertations / Theses on the topic 'PIK3'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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1

Mordant, Pierre. "Cancer bronchique primitif, voies de signalisation intra-cellulaires et modèles précliniques." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00809668.

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Contexte. Le cancer bronchopulmonaire (CBP) demeure la première cause de mortalité par cancer dans le monde. Malgré l'espoir suscité par le développement des thérapies ciblées, son pronostic demeure sombre, particulièrement dans les cas de CBP à petites cellules (CBP-PC) et de CBP non à petites cellules (CBP-NPC) présentant une activation de l'oncogène KRAS. Matériel et Méthodes. Nous avons mené 3 études successives, visant à (i) radiosensibiliser des modèles de CBP-PC par l'ajout d'un inhibiteur de BCL2, (ii) cibler des modèles de CBP-NPC mutés KRAS par l'association d'un inhibiteur de mTOR e
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Kielkowska, Anna Jadwiga. "The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273823.

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Name: Anna Jadwiga Kielkowska Dissertation title: The role of PTEN as a PI(3,4)P2 lipid phosphatase in Class I phosphoinositide 3-kinase signalling Abstract Class I phosphoinositide 3-kinases (Class I PI3Ks) are essential players involved in the signalling events in the cell and are critical promoters of cellular growth, survival and metabolism. Once activated by environmental stimuli such as growth factors, cytokines or antigens, they exert their catalytic activity by phosphorylating phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2) to yield a second messenger - PI(3,4,5)P3. Unrestrained PI
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3

Valet, Colin. "Rôles de la PI3 kinase de classe II alpha et de la PI3K de classe III, vps34, dans la production et les fonctions plaquettaires." Thesis, Toulouse 3, 2017. http://www.theses.fr/2017TOU30032.

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Les mégacaryocytes sont des cellules de la moelle osseuse qui par un processus complexe et encore mal caractérisé, mégacaryopoïèse/thrombopoïèse, donnent naissance, in fine, aux plaquettes sanguines. La différenciation mégacaryocytaire nécessite un intense remodelage nucléaire et cytoplasmique, guidé à la fois par des facteurs intrinsèques mais aussi par des facteurs extrinsèques tel que le microenvironnement médullaire. Les plaquettes sanguines sont des acteurs essentiels du maintien de l'intégrité vasculaire. Elles sont les premiers éléments cellulaires à intervenir dans l'arrêt du saignemen
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Stoor, Per. "Pika Pika? Pikachu! : En kvalitativ spelanalys av de socialt uppmuntrande designelementen i Pokemon Go." Thesis, Umeå universitet, Institutionen för informatik, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-130591.

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This paper is about how the location based game Pokemon Go motivates players to play the game outdoors and defining the games design principles and how they encourage social interaction between players. The paper has made use of three different qualitative data gathering methods, a brief ethnographical field study, semi structured interviews and an analysis based on theoretical frameworks used for conducting research about video games. Players were found to play outside for three reasons, the freedom of using a smartphone to play location based games, Pokemon Go’s location based game technolog
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Balakrishnan, Sanjeevi. "Establishing a biological role for class II phosphoinositide 3-kinase (PI3K) enzyme PI3K-C2??" Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/39135.

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Phosphoinositide 3-Kinase (PI3K) enzymes control a variety of cellular processes and their deregulation has been extensively investigated in disease conditions including renal disease, autoimmunity and chronic inflammation. Whilst PI3K enzymes have been the subject of intense research activity, the precise biological role of PI3K-C2?? enzyme remains unclear. PI3K-C2??-/- mice developed focal segmental glomerulosclerosis, damaging podocyte morphology and affecting function. My thesis explored the contribution of the PI3K-C2?? enzyme in the pathology of chronic diseases. PI3K-C2??flx/+ mice were
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Kumph, John Muir. "Maneuvering of a robotic pike." Thesis, Massachusetts Institute of Technology, 2000. http://hdl.handle.net/1721.1/8968.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering; and, (S.M.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 2000.<br>Includes bibliographical references (p. 75-76).<br>A robotic mechanism is described, called Robopike. The robot has fork length equal to 82cm, and contains 5 motors, a computer and a wireless modem for communication during testing. Details of the construction and testing methods are provided. The testing covered only a small part of the extensive parametric range, and resulted in speeds up to 0.11 body lengths per second
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7

Hale, Benjamin G. "Influenza A viruses and PI3K signalling." Thesis, University of St Andrews, 2007. http://hdl.handle.net/10023/483.

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The influenza A virus non-structural (NS1) protein is multifunctional, and during virus-infection NS1 interacts with several factors in order to manipulate host-cell processes. This study reports that NS1 binds directly to p85β, a regulatory subunit of phosphoinositide 3-kinase (PI3K), but not to the related p85α. Expression of NS1 was sufficient to activate PI3K and cause the phosphorylation of a downstream mediator of PI3K signalling, Akt. However, in virus-infected MDCK cells, the kinetics of Akt phosphorylation did not correlate with NS1 expression, and suggested that negative regulation o
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Hale, Benjamin G. "Influenza A viruses and PI3K signalling /." St Andrews, 2008. http://hdl.handle.net/10023/483.

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9

Engstedt, Olof. "Anadromous Pike in the Baltic Sea." Doctoral thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-13856.

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The pike (Esox lucius) is a major predator and top-down regulator in the Baltic Sea where it exists in two sympatric forms. One spawn in streams and rivers and the other one spawn in the sea. During the last decades, the habitats for both of these forms have developed in a negative way. In some freshwater systems, up to 90 % of the water areas have disappeared, mainly through drainage and straightening of watercourses for agricultural purposes. In the sea, reproduction habitats decrease due to construction of harbours and human activities that create disturbances. The perhaps largest single fa
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10

White, Angela R. "Shared PI3K signaling abnormalities in brain tumors and epilepsy: PI3K inhibition in PTEN-deficient disorders of the brain." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1603712831970142.

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11

Castel, Morales Pau. "Molecular mechanisms of resistance to PI3K inhibitors." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396640.

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The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated genes across human cancers, providing further understanding of the pathogenesis, molecular classification, and therapeutic strategies for this disease. PIK3CA, the gene encoding the PI3Kα isoform, is among the most frequently mutated genes in breast, head and neck, colorectal, and lung cancer, among others. Activating mutations in PIK3CA promote hyperactivation of the PI3
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Figueiredo, Ana Raquel Martins. "Role of PI3K in pericytes during angiogenesis." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/404276.

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Pericytes (PCs) are important regulators of the vascular development promoting vessel growth and stabilization. They have recently emerged as a therapeutic target to promote or inhibit angiogenesis. Therefore, advancing our basic understanding on PCs biology and its molecular regulators during physiological angiogenesis is essential to develop PC-related therapies. One of the major pathways leading to cellular proliferation, migration, and survival is relayed by PI3K. Data from our laboratory and others have demonstrated isoform selectivity stimulating PI3K signalling in the regulation of both
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Zunder, Eli Richard. "A yeast screen for PI3K inhibitor resistance." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339211.

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14

Riquelme, Maturana Andrés O. "Hanga Piko : puerta marítima a Rapa Nui." Tesis, Universidad de Chile, 2012. http://repositorio.uchile.cl/handle/2250/111429.

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Memoria (arquitecto)<br>Rapa Nui se encuentra en un estado muy deplorable, para la importancia cultural que po¬see, no solo en su contexto geográfico inmediato, sino que para el mundo entero, ya que por sus condiciones patrimoniales la hacen ser una de las Islas más importantes del Océano Pacífico y más aun de la Cultura Polinésica, debido a que es una de los tres vértices de lo que se considera el Triángulo Polinésico (Hawái-Nueva Zelanda- Isla de Pascua). El turismo maritimo en Isla de Pascua se ha vis¬to muy afectado por el creciente tránsito aéreo, ya que prácticamente se ha volcado hacia
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Fedrigo, Carlos Alexandre. "Inibição da via PI3K-Akt em gliomas." Pontifícia Universidade Católica do Rio Grande do Sul, 2012. http://hdl.handle.net/10923/4518.

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Made available in DSpace on 2013-08-07T19:05:17Z (GMT). No. of bitstreams: 1 000439149-Texto+Completo-0.pdf: 1490829 bytes, checksum: bd616615ee5265db0a960d6f77c8581d (MD5) Previous issue date: 2012<br>Glioblastoma multiforme (GMB) is the most malignant and common type of all astrocytic tumours. Current standard treatment for GBM patients involves maximum surgical resection of the tumour, followed by radiotherapy and chemotherapy, usually containing the alkylating agent Temozolomide (TMZ). Despite this aggressive combination therapy, the survival rate of GBM patients is still low. This work
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16

Larenas, Orellana Felipe A. "Reconfiguración Caleta Hanga Piko, Isla de Pascua." Tesis, Universidad de Chile, 2010. http://repositorio.uchile.cl/handle/2250/100185.

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La importancia del turismo para la isla, requiere de adecuados accesos de los turistas, donde pueda además realizarse el necesario control de la entrada, que sólo pueden hacerlo por dos vías: vía aérea, que cuenta con un proyecto de remodelación; y por vía marítima, que en la actualidad se localiza en Hanga Piko, lugar que no cuenta con el carácter de puerta de entrada a la Isla, se configura de diversas construcciones sin relaciones entre sí, no posee unidad, no reconoce los ahús existentes y no cuenta con el programa necesario para acoger a los visitantes de cruceros ni yates. El proyecto pr
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Ramos, Delgado Carmen Fernanda. "Exploring PI3K signalling dynamics in pancreatic cancer." Thesis, Toulouse 3, 2020. http://www.theses.fr/2020TOU30152.

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Les PI3K sont des enzymes qui phosphorylent le groupe hydroxyl en position 3 des phosphatidylinositols comme le PIP2 ou le PI. Ces lipides sont impliqués dans de nombreux processus cellulaires tels que la croissance, la prolifération, la motilité, l'autophagie et le trafic cellulaire. Chez les mammifères, il y a 8 isoformes de PI3K et elles sont regroupées en trois classes (I, II et III) en fonction de leur structure et spécificité du substrat. Les PI3K de classe I sont les mieux caractérisées et impliquées dans le cancer. Les rôles oncogéniques des PI3K de classe II et III restent méconnus. L
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Karnes, Jonathan Burgess. "PI3K Class IIalpha Is Required for Autophagy." Thesis, Van Andel Research Institute, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10268645.

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<p> Autophagy is a cellular recycling process in which cytoplasmic proteins and organelles are sequestered in a double membrane vesicle, delivered to the lysosome, and degraded following fusion of the two vesicles. A key part of the initiation signaling for autophagy is the generation of phosphoinositol 3-phosphate (P13P) by class III phosphoinositol 3-kinase also knows as Vps 34. In humans there are eight P13K isoforms divided into three classes, four class I enzymes, three class II enzymes, and a single class III enzyme. Of these eight enzymes, only the class III isoform is thought to partic
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Armstrong, John Duncan. "Metabolism, feeding and cardiac function in pike, Esox lucius." Thesis, University of Aberdeen, 1987. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=189461.

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Aspects of the physiological ecology of pike from an upland Scottish loch have been studied. A small laboratory stock was maintained in a healthy, feeding condition to allow measurements of a range of physiological and behavioural parameters. Resting and maximum metabolic rates increase with body size and the relationship between weight and oxygen consumption can be described by regression equations of the form: Y = ax<sup>6</sup>. The ratio of resting : maximum oxygen consumption (the metabolic expansibility coefficient) increases with body-weight. Heart rate increases during activity and fee
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20

Sentandreu, Benavent Maria. "Functional Profiling of PIF3 Regulated Genes in the Dark / Análisis funcional de los genes regulados por PIF3 en oscuridad." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/117353.

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After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed apical hook and cotiledons in order to protect the apical meristem while passing through the soil. The phytochrome (phy)-interacting basic helix-loop-helix transcription factors (PIFs) constitutively sustain the etiolated state of dark-germinated seedlings by actively repressing deetiolation in darkness. This action is rapidly reversed upon light exposure by phy-induced proteoly
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Marshall, Andrew James. "The development of PI3K inhibitors as anticancer drugs." Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/6440.

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Phosphatidylinositol 3-kinases (PI3Ks) are a lipid enzyme family that are vitally important regulators of intracellular signalling pathways which control cellular activities including cell survival, growth and proliferation. Deregulation of the PI3K signalling cascade has been observed in a broad range of human diseases including cancer, diabetes, thrombosis, immunity and inflammatory disorders. With the discovery of PI3K’s link to a variety of diseases, there has been a race to produce ATP competitive inhibitors as therapeutic agents against the Class I PI3K isozymes. Herein, compounds from t
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Killip, Marian J. "RNA virus modulation of IFN, PI3K and apoptosis." Thesis, St Andrews, 2009. http://hdl.handle.net/10023/777.

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Patton, Daniel Timothy. "The role of PI3K p110δ in T cells". Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612110.

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Kumph, John Muir. "The design of a free swimming robot pike." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/10612.

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Fedrigo, Carlos Alexandre. "Inibi??o da via PI3K-Akt em gliomas." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2012. http://tede2.pucrs.br/tede2/handle/tede/1696.

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Made available in DSpace on 2015-04-14T13:35:33Z (GMT). No. of bitstreams: 1 439149.pdf: 1490829 bytes, checksum: bd616615ee5265db0a960d6f77c8581d (MD5) Previous issue date: 2012-05-29<br>Glioblastoma multiforme (GMB) is the most malignant and common type of all astrocytic tumours. Current standard treatment for GBM patients involves maximum surgical resection of the tumour, followed by radiotherapy and chemotherapy, usually containing the alkylating agent Temozolomide (TMZ). Despite this aggressive combination therapy, the survival rate of GBM patients is still low. This work consisted in i
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Duarte, Andressa. "Participação da via PI3K/AKT na produção de óxido nítrico por macrófagos peritoneais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-21102013-112320/.

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A imunidade inata é responsável pela resposta inicial aos microrganismos, uma vez que impede, controla ou elimina a infecção. Esse sistema consiste em barreiras epiteliais, proteínas plasmáticas e células circulantes e teciduais. Dentre esses componentes, os macrófagos possuem grande importância, sendo capazes de controlar e eliminar agentes patogênicos através da fagocitose e produção de espécies reativas de oxigênio e nitrogênio. A ativação de PRRs por constituintes oriundos dos patógenos em macrófagos desencadeia eventos da resposta imune inata, ativados por diversas vias de sinalização int
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Chu, Ying Ying Julia. "Apoptosis is promoted by unconventional FcγR-PI3KCdc42-Pak-Mek-Erk signalling in the human neutrophil". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28813.

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Neutrophils form a first line of defence against infections. These short-lived, terminally differentiated cells perform many important functions, including chemotaxis, degranulation, reactive oxygen species (ROS) release and cytokine production. Whilst neutrophils are essential for host immunity, their inappropriate recruitment, activation and/or removal can contribute to excessive inflammation and host damage, as exemplified in autoimmune diseases such as rheumatoid arthritis. It is therefore essential that neutrophil function is tightly regulated. Neutrophils are activated by a range of stim
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López, Fauqued Marta. "Preclinical Study of PI3K and BRAF Inhibitors in Malignant Melanoma / Estudio preclínico de inhibidores de PI3K y BRAF en melanoma maligno." Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/1040.

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Malignant melanoma is the most lethal skin cancer with no effective therapeutic treatment in its metastatic stages. RAS and PI3K pathways have been shown to play a critical role in melanoma development and progression. In this study, we assessed the in vitro and in vivo inhibition potential of a BRAF inhibitor (Sorafenib, Bayer) and a PI3K/mTOR inhibitor (PI-103, PIramed-Genentech) in primary melanoma cell lines. We used primary cell lines isolated from spontaneous melanomas obtained in the UV induced HGF transgenic melanoma mouse model.<br/><br/>Although PI-103 and sorafenib inhibited melanom
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Ma, Kewei. "Investigation of the phosphatidylinositol 3-kinase pathway in B cells." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/3818.

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There is hardly a cellular process that is not regulated in some way by phosphoinositides, which makes biochemical and physiological studies of these lipids extremely important. PI 3-kinases are key regulators of phosphoinositide metabolism and have been shown to affect a large variety of cellular responses. The key products of PI 3-kinases that have functional activity in higher eukaryotic cells are PI(3,4,5)P₃ and PI(3,4)P₂. PI(3,4,5)P₃ is universally accepted as one of the most important second messengers in signal transduction. However, our knowledge of the functions of PI(3,4)P₂ as a lipi
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Boller, Danielle. "The role of PI3K signaling in neuroblastoma and glioblastoma /." Zürich, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253047.

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Pothiraju, Deepika [Verfasser]. "Targeting PI3K/mTOR pathway in hepatocellular carcinoma / Deepika Pothiraju." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/1013286243/34.

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Agnew, Kelly Kathleen. "Butterfly oviposition behavior, pika biogeography, and lentiviral sequence evolution /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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Hervieu, Vilches Alexia. "Understanding and targeting PI3K downstream of oncogenic Met mutant." Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/33935.

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The Receptor Tyrosine Kinase (RTK) Met, overexpressed or mutated in cancer, plays a major role in cancer progression and represents an attractive target for cancer therapy. This study aimed to investigate whether PI3K plays a role in Met oncogenicity. Three cell models were used: (i) NIH3T3 cells expressing WT Met or the constitutively active mutant M1268T Met; (ii) U87MG glioblastoma cells, with endogenous WT Met constitutively activated due to an autocrine loop; (iii) A549 lung cancer cells expressing endogenous WT Met, activated upon binding exogenous HGF. Met dependent Rac1 translocation t
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Nunes, Tinoco Nunes. "Estudo funcional da via PI3K/AKT em Aedes aegypti." Botucatu, 2018. http://hdl.handle.net/11449/157112.

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Orientador: Jayme Augusto de Souza Neto<br>Resumo: Aedes aegypti é a espécie de mosquito emergente em áreas urbanas com maior impacto na saúde pública, sendo o principal vetor dos arbovírus dengue, Zika e chikungunya. Por esse motivo, se faz indispensável a compreensão de mecanismos moleculares associados a processos fisiológicos em A. aegypti, como resposta imune, comportamento e homeostase intestinal. Conforme observado em outros organismos, a via PI3K/AKT tem papéis importantes no metabolismo, na reprodução, na tolerância ao estresse e na imunidade. A quinase AKT atua como um regulador nega
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Sears, Daniel. "Identification of PI3K/Akt targets in chronic myeloid leukaemia." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505451.

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Frith, Harold Russ. "Energetics of fast-starts in northern pike, Esox lucius." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30834.

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Fast-starts are high powered events of short duration, used by fish for prey capture and escape from predation. Here, the energetic cost of fast-starts in escape and prey capture for a fast-start specialist, the northern pike, Esox lucius, are determined and physiological and behavioural constraints assessed. This is done by comparing costs with literature values for physiological limits set my muscle mechanics and biochemistry, and comparing costs with other components of the energy budget. The combination of high speed film analysis (200-250Hz) and hydrodynamic models are used to determine
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Balista, Priscila Alves. "Inibidores de fosfatidilinositol-3-cinase (PI3K) e neuroproteção mediada pela cascata de sinalização da Akt na fase aguda do modelo de Pilocarpina." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/17/17140/tde-17022011-144706/.

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Introdução: A epilepsia do lobo temporal (ELT) é a forma mais frequente de epilepsia em adultos. Um modelo experimental de ELT consiste na indução de status epilepticus (SE) em animais por administração de Pilocarpina. Este modelo induz mudanças patofisiológicas e comportamentais em ratos muito semelhantes às observadas em seres humanos com ELT. Apesar da literatura apresentar dados relacionados às respostas celulares, pouco se conhece a respeito do envolvimento de cascatas de sinalização com insultos epileptogênicos no sistema nervoso. A enzima fosfatidilinositol-3-cinase (PI3K) está envolvi
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Proctor, Victoria Kate. "Signalling pathways linking interleukin 13 receptor activation to lung epithelial cell function." Thesis, University of Bath, 2013. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589658.

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The passage of fluid, ions and macromolecules across the epithelium is controlled primarily by epithelial tight junctions. Altered epithelial permeability is associated with lung disease, and barrier function is impaired by the Th2 cytokine IL-13. This thesis investigates the signalling pathways involved in the modulation of the epithelial barrier by IL-13 stimulation. Initial experiments demonstrated that the human sub-bronchial epithelial cell line Calu-3 could be easily manipulated when grown using an air-liquid culture system. Expression of various key tight junction proteins was demonstra
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Headrick, Michael Ray. "Bioenergetic constraints on habitat use by northern pike (Esox lucius) in Ohio reservoirs /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487260531955095.

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Torroba, Balmori Mª Blanca. "The Multiple Tasks Endured by PI3K during neural tube development." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399595.

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Development of the spinal cord involves coordination between exposure to localized extracellular signals and controlled activation of intracellular signaling pathways. This way, neuroepithelial cells firstly proliferate apically to increase the progenitor pool and, later on, initiate neurogenic divisions giving rise to a variety of neuronal cell types. Class IA PI3Ks are heterodimeric enzymes (catalytic+regulatory subunits) activated by receptors tyrosine kinase (RTKs) or G protein coupled receptors (GPCRs) that, upon extracellular stimuli, modulate diverse target proteins through local produc
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Guerrero, Hernández Martina. "Targeting tumor microenvironment crosstalk through GPCR receptors and PI3K pathway." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667975.

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The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different pathways. Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma. Although FL is generally characterized by slow progression and high response rates to therapy, it is still considered incurable, because almost virtually all the patients relapse. FL is probably the NHL with the highest dependence on microenvironment. PI3K is a common denominator transducing the sig
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Körtl, Thomas [Verfasser], and Sven A. [Akademischer Betreuer] Lang. "PI3K-Inhibition im Pankreaskarzinommodell / Thomas Körtl ; Betreuer: Sven A. Lang." Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1199104353/34.

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43

Dobler, Melanie. "Analyse des PI3K-Signalwegs bei der Entstehung des duktalen Pankreaskarzinoms." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-172239.

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44

Fero, Daniel James. "The role of PI3K in Ephrin-A1 induced cell retraction." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3315045.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed August 4, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 104-113).
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45

Cizkova, Magdalena. "Pronostic and Predictive Markers in Breast Cancer - PI3K Signaling Pathway." Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T021.

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Les résultats des projets actuels apportent une information, sur différents aspects des rôles de la voie PI3K, dans le développement du cancer du sein, et la réponse au traitement. Les projets particuliers couvrent des sujets liés à la voie aux niveaux concernant les récepteurs de la famille HER, activant la voie PI3K, ainsi que PI3K et les effecteurs en découlant. Les effets pronostic et prédictif de la dérégulation de PI3K sont les sujets centraux de la recherche décrite ici. Une baisse d’expression de PI3KR1 est associée à une survie réduite dans notre cohorte de patients. Une attention par
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46

Wang, Ling, and Shunbin Ning. "LMP1 Signaling Pathway Activates IRF4 through the PI3K-Src Axis." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/6544.

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47

Stott, Nathan Daniel Stott. "Northern Pike abundance and natal fidelity in Lake Erie marshes." Bowling Green State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1530892530309374.

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48

Tavelis, Christodoulos. "Investigating the potential role of PIP4Ks in PI3K/Akt signalling." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-potential-role-of-pip4ks-in-pi3kakt-signalling(e70d9473-5932-468a-bdad-01668a68db58).html.

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Class I phosphoinositide 3-kinases (PI3Ks) generate the essential lipid second messenger PtdIns(3,4,5)P3 which plays a key role in the regulation of numerous cellular processes including cell growth and survival, gene transcription, cytoskeletal organisation and glucose metabolism through its downstream effectors and in particular the serine/threonine protein kinase Akt. Therefore, the PI3K/Akt signalling plays a critical regulatory role in diverse cellular processes and its dysregulation is implicated in the pathogenesis of many human diseases including cancer and type 2 diabetes. Overexpress
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Stamatkin, Christopher W. "PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) AS A THERAPEUTIC TARGET IN NSCLC." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/58.

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Deregulated activation of phosphatidylinositol 3-kinase (PI3K) pathway is central to many human malignancies. The functions of this pathway are critical for normal cell metabolism, proliferation, and survival. In lung cancers, the PI3K pathway activity is often aberrantly driven by multiple mutations, including EGFR, KRAS, and PIK3CA. Molecules targeting the PI3K pathway are intensely investigated as potential anti-cancer agents. Although inhibitors of the pathway are currently in clinical trials, rational and targeted use of these compounds, alone or in combination, requires an understanding
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Lucas, Martyn Charles. "Metabolic power budgeting in fishes : laboratory studies in zebra fish, Brachydanio rerio and heart-rate telemetry in pike, Esox lucius." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 1989. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=59648.

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Thesis (Ph.D.)--Aberdeen University, 1989.<br>Title from web page (viewed on Mar. 4, 2010). Accompanying offprints stored in end pocket. With: A combined radio and acoustic transmitter for fixing direction and range of freshwater fish (RAFIX) / J.D. Armstrong ... et al. J. Fish Biol. 33, 879-884. With: An acoustic telemetry system for monitoring the heart rate of pike, Esox Lucius L. and other fish in their natural environment / J.D. Armstong ... et. J. Exp Bio 1989: 143, 549-552. With: Effects of implanted dummy transmitters on mortality, growth and tissue reaction in rainbow trout, Salmo gai
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