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Journal articles on the topic 'Pili de type IVa'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Evans, Katy J., Carey Lambert, and R. Elizabeth Sockett. "Predation by Bdellovibrio bacteriovorus HD100 Requires Type IV Pili." Journal of Bacteriology 189, no. 13 (2007): 4850–59. http://dx.doi.org/10.1128/jb.01942-06.

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ABSTRACT Early electron microscopy and more recent studies in our laboratory of Bdellovibrio bacteriovorus cells indicated the presence of narrow fibers at the nonflagellar pole of this unusual predatory bacterium. Analysis of the B. bacteriovorus HD100 genome showed a complete set of genes potentially encoding type IV pili and an incomplete gene set for Flp pili; therefore, the role of type IV pili in the predatory life cycle of B. bacteriovorus HD100 was investigated. Alignment of the predicted PilA protein with known type IV pilins showed the characteristic conserved N terminus common to ty

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2

Harvey, Hanjeong, Marc Habash, Francisca Aidoo, and Lori L. Burrows. "Single-Residue Changes in the C-Terminal Disulfide-Bonded Loop of the Pseudomonas aeruginosa Type IV Pilin Influence Pilus Assembly and Twitching Motility." Journal of Bacteriology 191, no. 21 (2009): 6513–24. http://dx.doi.org/10.1128/jb.00943-09.

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ABSTRACT PilA, the major pilin subunit of Pseudomonas aeruginosa type IV pili (T4P), is a principal structural component. PilA has a conserved C-terminal disulfide-bonded loop (DSL) that has been implicated as the pilus adhesinotope. Structural studies have suggested that DSL is involved in intersubunit interactions within the pilus fiber. PilA mutants with single-residue substitutions, insertions, or deletions in the DSL were tested for pilin stability, pilus assembly, and T4P function. Mutation of either Cys residue of the DSL resulted in pilins that were unable to assemble into fibers. Ala

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3

de Bentzmann, Sophie, Marianne Aurouze, Geneviève Ball, and Alain Filloux. "FppA, a Novel Pseudomonas aeruginosa Prepilin Peptidase Involved in Assembly of Type IVb Pili." Journal of Bacteriology 188, no. 13 (2006): 4851–60. http://dx.doi.org/10.1128/jb.00345-06.

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ABSTRACT Several subclasses of type IV pili have been described according to the characteristics of the structural prepilin subunit. Whereas molecular mechanisms of type IVa pilus assembly have been well documented for Pseudomonas aeruginosa and involve the PilD prepilin peptidase, no type IVb pili have been described in this microorganism. One subclass of type IVb prepilins has been identified as the Flp prepilin subfamily. Long and bundled Flp pili involved in tight adherence have been identified in Actinobacillus actinomycetemcomitans, for which assembly was due to a dedicated machinery enc

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4

Wairuri, Charles K., Jacquie E. van der Waals, Antoinette van Schalkwyk, and Jacques Theron. "Ralstonia solanacearum Needs Flp Pili for Virulence on Potato." Molecular Plant-Microbe Interactions® 25, no. 4 (2012): 546–56. http://dx.doi.org/10.1094/mpmi-06-11-0166.

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Type IV pili are virulence factors in various bacteria. Several subclasses of type IV pili have been described according to the characteristics of the structural prepilin subunit. Although type IVa pili have been implicated in the virulence of Ralstonia solanacearum, type IVb pili have not previously been described in this plant pathogen. Here, we report the characterization of two distinct tad loci in the R. solanacearum genome. The tad genes encode functions necessary for biogenesis of the Flp subfamily of type IVb pili initially described for the periodontal pathogen Aggregatibacter actinom

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5

Chlebek, Jennifer L., Hannah Q. Hughes, Aleksandra S. Ratkiewicz, et al. "PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili." PLOS Genetics 15, no. 10 (2019): e1008448. http://dx.doi.org/10.1371/journal.pgen.1008448.

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6

Hughes, Hannah Q., Nicholas D. Christman, Triana N. Dalia, Courtney K. Ellison, and Ankur B. Dalia. "The PilT retraction ATPase promotes both extension and retraction of the MSHA type IVa pilus in Vibrio cholerae." PLOS Genetics 18, no. 12 (2022): e1010561. http://dx.doi.org/10.1371/journal.pgen.1010561.

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Diverse bacterial species use type IVa pili (T4aP) to interact with their environments. The dynamic extension and retraction of T4aP is critical for their function, but the mechanisms that regulate this dynamic activity remain poorly understood. T4aP are typically extended via the activity of a dedicated extension motor ATPase and retracted via the action of an antagonistic retraction motor ATPase called PilT. These motors are generally functionally independent, and loss of PilT commonly results in T4aP hyperpiliation due to undeterred pilus extension. However, for the mannose-sensitive hemagg

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7

Iruegas, Ruben, Katharina Pfefferle, Stephan Göttig, Beate Averhoff, and Ingo Ebersberger. "Feature architecture aware phylogenetic profiling indicates a functional diversification of type IVa pili in the nosocomial pathogen Acinetobacter baumannii." PLOS Genetics 19, no. 7 (2023): e1010646. http://dx.doi.org/10.1371/journal.pgen.1010646.

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The Gram-negative bacterial pathogen Acinetobacter baumannii is a major cause of hospital-acquired opportunistic infections. The increasing spread of pan-drug resistant strains makes A. baumannii top-ranking among the ESKAPE pathogens for which novel routes of treatment are urgently needed. Comparative genomics approaches have successfully identified genetic changes coinciding with the emergence of pathogenicity in Acinetobacter. Genes that are prevalent both in pathogenic and a-pathogenic Acinetobacter species were not considered ignoring that virulence factors may emerge by the modification

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8

Orndorff, Paul E., Aditya Devapali, Sarah Palestrant, et al. "Immunoglobulin-Mediated Agglutination of and Biofilm Formation by Escherichia coli K-12 Require the Type 1 Pilus Fiber." Infection and Immunity 72, no. 4 (2004): 1929–38. http://dx.doi.org/10.1128/iai.72.4.1929-1938.2004.

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ABSTRACT The binding of human secretory immunoglobulin A (SIgA), the primary immunoglobulin in the gut, to Escherichia coli is thought to be dependent on type 1 pili. Type 1 pili are filamentous bacterial surface attachment organelles comprised principally of a single protein, the product of the fimA gene. A minor component of the pilus fiber (the product of the fimH gene, termed the adhesin) mediates attachment to a variety of host cell molecules in a mannose inhibitable interaction that has been extensively described. We found that the aggregation of E. coli K-12 by human secretory IgA (SIgA

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9

Dahlgren, U. I., S. Ahlstedt, and L. A. Hanson. "The localization of the antibody response in milk or bile depends on the nature of the antigen." Journal of Immunology 138, no. 5 (1987): 1397–402. http://dx.doi.org/10.4049/jimmunol.138.5.1397.

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Abstract Immunization in the Peyer's patches of rats with horse spleen ferritin or Escherichia coli 06 carrying type 1 pili resulted in an IgA antibody response detected in milk and bile and an IgG and IgM antibody response in serum, milk, and bile. The IgA antibody response to type 1 pili was as a mean 5.0-fold higher in milk than in bile. In contrast IgA antibody activity to 06 LPS was as a mean 6.3-fold higher in bile than in milk. The IgA antibodies to ferritin were randomly distributed between milk and bile. The IgG and IgM antibody activity to all three antigens studied were higher in th

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10

Quigley, Bernard R., Matthew Hatkoff, David G. Thanassi, Mahamoudou Ouattara, Zehava Eichenbaum, and June R. Scott. "A Foreign Protein Incorporated on the Tip of T3 Pili in Lactococcus lactis Elicits Systemic and Mucosal Immunity." Infection and Immunity 78, no. 3 (2009): 1294–303. http://dx.doi.org/10.1128/iai.01037-09.

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ABSTRACT The use of Lactococcus lactis to deliver a chosen antigen to the mucosal surface has been shown to elicit an immune response in mice and is a possible method of vaccination in humans. The recent discovery on Gram-positive bacteria of pili that are covalently attached to the bacterial surface and the elucidation of the residues linking the major and minor subunits of such pili suggests that the presentation of an antigen on the tip of pili external to the surface of L. lactis might constitute a successful vaccine strategy. As a proof of principle, we have fused a foreign protein (the E

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11

Reardon, Patrick N., and Karl T. Mueller. "Structure of the Type IVa Major Pilin from the Electrically Conductive Bacterial Nanowires ofGeobacter sulfurreducens." Journal of Biological Chemistry 288, no. 41 (2013): 29260–66. http://dx.doi.org/10.1074/jbc.m113.498527.

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12

Boddey, Justin A., Cameron P. Flegg, Chris J. Day, Ifor R. Beacham, and Ian R. Peak. "Temperature-Regulated Microcolony Formation by Burkholderia pseudomallei Requires pilA and Enhances Association with Cultured Human Cells." Infection and Immunity 74, no. 9 (2006): 5374–81. http://dx.doi.org/10.1128/iai.00569-06.

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ABSTRACT Burkholderia pseudomallei is the causative agent of melioidosis, a potentially fatal disease that is endemic to Northern Australia and Southeast Asia and is acquired from soil or water. Adherence of B. pseudomallei 08 to cultured cells increases dramatically following prior growth at 30°C or less compared to that following prior growth at 37°C. Here, we show that this occurs almost entirely as the result of microcolony formation (bacterium-bacterium interactions) following growth at 27°C but not at 37°C, which considerably enhances bacterial association with eukaryotic cells. Further,

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13

Allison, Tara M., Sean Conrad, and Peter Castric. "The group I pilin glycan affects type IVa pilus hydrophobicity and twitching motility in Pseudomonas aeruginosa 1244." Microbiology 161, no. 9 (2015): 1780–89. http://dx.doi.org/10.1099/mic.0.000128.

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14

Bollinger, R. Randal, Mary Lou Everett, Shaina D. Wahl, Yu-Huei Lee, Paul E. Orndorff, and William Parker. "Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili." Molecular Immunology 43, no. 4 (2006): 378–87. http://dx.doi.org/10.1016/j.molimm.2005.02.013.

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15

Colicchio, Roberta, Chiara Pagliuca, Gabiria Pastore, et al. "Fitness Cost of Rifampin Resistance in Neisseria meningitidis:In VitroStudy of Mechanisms Associated withrpoBH553Y Mutation." Antimicrobial Agents and Chemotherapy 59, no. 12 (2015): 7637–49. http://dx.doi.org/10.1128/aac.01746-15.

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ABSTRACTRifampin chemoprophylaxis againstNeisseria meningitidisinfections led to the onset of rifampin resistance in clinical isolates harboring point mutations in therpoBgene, coding for the RNA polymerase β chain. These resistant strains are rare in medical practice, suggesting their decreased fitness in the human host. In this study, we isolated rifampin-resistantrpoBmutants from hypervirulent serogroup C strain 93/4286 and analyzed their different properties, including the ability to grow/survive in different culture media and in differentiated THP-1 human monocytes and to compete with the

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16

Reardon-Robinson, Melissa E., Chenggang Wu, Arunima Mishra, et al. "Pilus hijacking by a bacterial coaggregation factor critical for oral biofilm development." Proceedings of the National Academy of Sciences 111, no. 10 (2014): 3835–40. http://dx.doi.org/10.1073/pnas.1321417111.

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The formation of dental plaque, a highly complex biofilm that causes gingivitis and periodontitis, requires specific adherence among many oral microbes, including the coaggregation ofActinomyces oriswithStreptococcus oralisthat helps to seed biofilm development. Here, we report the discovery of a key coaggregation factor for this process. This protein, which we named coaggregation factor A (CafA), is one of 14 cell surface proteins with the LPXTG motif predicted inA. orisMG1, whose function was hitherto unknown. By systematic mutagenesis of each of these genes and phenotypic characterization,

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17

Białecka, Joanna, Katarzyna Rak, and Aneta Kiecka. "Gonococci – Pathogens of Growing Importance. Part 2. Virulence Factors, Antimicrobial Resistance and Vaccine Development." Advancements of Microbiology 63, no. 2 (2024): 113–25. http://dx.doi.org/10.2478/am-2024-0010.

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Abstract Neisseria gonorrhoeae (gonococcus) is a human pathogen, the aetiological agent of gonorrhoea, which is the second most common bacterial sexually transmitted disease (STD) in the world. The structure of N. gonorrhoeae cell wall is typical of Gram-negative bacteria, poses variable antigens porin B (PorB), and opacity-associated proteins (Opa proteins), lipooligosaccharide (LOS) and type IV pili (TFP) playing an essential role in pathogenesis. In addition to adhesins, gonococcus presents other virulence factors such as reducing modifiable protein (Rmp), iron transporters, membrane pumps,

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18

A. Ali, Fattma. "The Role of Virulence Factors of Haemophilus Influenza." Journal of Clinical Case Reports & Studies 6, no. 1 (2025): 01–05. https://doi.org/10.31579/2690-8808/237.

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Background: Haemophilus influenzae is a pathogenic bacterium that frequently leads to serious infections, especially in newborns. Haemophilus influenzae is a Gram-ve coccobacillus belonging to the Pasteurellaceae family. It is microscopic in size, ranging from 0.3 to 1 micrometers. Its facultative anaerobic can survive with or without oxygen and has the ability to change its shape. It grows in an environment with increased levels of carbon dioxide. The development of this organism on chocolate agar is facilitated by a medium that contains two erythrocyte factors: factor X (hematin) and factor

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19

Khoobbakht, Dorna, Shohreh Zare Karizi, Mohammad Javad Motamedi, Rouhollah Kazemi, Pooneh Roghanian, and Jafar Amani. "Immunogenicity Evaluation of Chimeric Subunit Vaccine Comprising Adhesion Coli Surface Antigens from Enterotoxigenic Escherichia coli." Journal of Molecular Microbiology and Biotechnology 29, no. 1-6 (2019): 91–100. http://dx.doi.org/10.1159/000509708.

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Enterotoxigenic <i>Escherichia coli</i> (ETEC) is the most common agent of diarrhea morbidity in developing countries. ETEC adheres to host intestinal epithelial cells via various colonization factors. The CooD and CotD proteins play a significant role in bacteria binding to the intestinal epithelial cells as adhesin tip subunits of CS1 and CS2 pili. The purpose here was to design a new construction containing <i>cooD</i> and <i>cotD</i> genes and use several types of bioinformatics software to predict the structural and immunological properties of the desig

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20

Biais, Nicolas. "Pili de type IV." médecine/sciences 25, no. 5 (2009): 437–38. http://dx.doi.org/10.1051/medsci/2009255437.

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21

Marinova, S., P. Nenkov, R. Markova, et al. "Cellular and Humoral Systemic and Mucosal Immune Responses Stimulated by an Oral Polybacterial Immunomodulator in Patients with Chronic Urinary Tract Infections." International Journal of Immunopathology and Pharmacology 18, no. 3 (2005): 457–73. http://dx.doi.org/10.1177/039463200501800306.

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An oral polybacterial immunomodulator Urostim (U), composed of killed cells and their lysates from E. coli expressing type 1 and P-pili, E. coli Re mutant, P. mirabilis, K. pneumoniae and E. faecalis was created for immunoprophylaxis and immunotherapy of urinary tract infections (UTIs). In experimental animal models, the stimulating effect of U on lymphocyte functional activity, macrophage phagocytosis and antibody producing cells, was established. In this study the immuno-modulating effects of U on the proliferating capacity and ultrastructural morphologic changes of lymphocytes, cytokine pro

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22

De La Fuente, Leonardo, Emilie Montanes, Yizhi Meng, et al. "Assessing Adhesion Forces of Type I and Type IV Pili of Xylella fastidiosa Bacteria by Use of a Microfluidic Flow Chamber." Applied and Environmental Microbiology 73, no. 8 (2007): 2690–96. http://dx.doi.org/10.1128/aem.02649-06.

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ABSTRACT Xylella fastidiosa, a bacterium responsible for Pierce's disease in grapevines, possesses both type I and type IV pili at the same cell pole. Type IV pili facilitate twitching motility, and type I pili are involved in biofilm development. The adhesiveness of the bacteria and the roles of the two pili types in attachment to a glass substratum were evaluated using a microfluidic flow chamber in conjunction with pilus-defective mutants. The average adhesion force necessary to detach wild-type X. fastidiosa cells was 147 ± 11 pN. Mutant cells possessing only type I pili required a force o

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23

Farnia, Parissa, Gennady Konstantinovich Zhavnerko, Poopak Farnia, Nikolai Nikolaevich Poleschuyk, Jalaledin Ghanavi, and Ali Akbar Velayati. "Identification of Seven Types of Pili in Mycobacterium tuberculosis: Using Atomic Force Microscopy." International Journal of Mycobacteriology 12, no. 4 (2023): 478–85. http://dx.doi.org/10.4103/ijmy.ijmy_190_23.

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Background: Pili are polymeric, hydrophobic, proteinaceous structures generally composed of a major repeating subunit called pilin and, in some cases, a minor tip-associated adhesin subunit. Pili are involved in many virulence-associated functions, such as biofilm formation, adherence, and colonization of mucosal surfaces. Methods: Mycobacterium tuberculosis (MTB) strains were isolated from clinically and laboratory-confirmed cases of tuberculosis (TB). The TB isolates were subjected to the Xpert MTB/rifampicin test and then, further susceptibility testing was performed on them against first-

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24

Stone, Barbara J., and Yousef Abu Kwaik. "Natural Competence for DNA Transformation by Legionella pneumophila and Its Association with Expression of Type IV Pili." Journal of Bacteriology 181, no. 5 (1999): 1395–402. http://dx.doi.org/10.1128/jb.181.5.1395-1402.1999.

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ABSTRACT We have recently described the expression of two pili of different lengths on the surface of Legionella pneumophila (B. J. Stone and Y. Abu Kwaik, Infect. Immun. 66:1768–1775, 1998). Production of long pili requires a functional pilE L locus, encoding a type IV pilin protein. Since type IV pili in Neisseria gonorrhoeaeare associated with competence for DNA transformation, we examined the competence of L. pneumophila for DNA transformation under conditions that allowed the expression of type IV pili. We show that L. pneumophila is naturally competent for DNA transformation by isogenic

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25

van Schaik, Erin J., Carmen L. Giltner, Gerald F. Audette, et al. "DNA Binding: a Novel Function of Pseudomonas aeruginosa Type IV Pili." Journal of Bacteriology 187, no. 4 (2005): 1455–64. http://dx.doi.org/10.1128/jb.187.4.1455-1464.2005.

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ABSTRACT The opportunistic pathogen Pseudomonas aeruginosa produces multifunctional, polar, filamentous appendages termed type IV pili. Type IV pili are involved in colonization during infection, twitching motility, biofilm formation, bacteriophage infection, and natural transformation. Electrostatic surface analysis of modeled pilus fibers generated from P. aeruginosa strain PAK, K122-4, and KB-7 pilin monomers suggested that a solvent-exposed band of positive charge may be a common feature of all type IV pili. Several functions of type IV pili, including natural transformation and biofilm fo

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26

Van Eyssen, Shelly Roselyn, Anastasia Samarkina, Ovgu Isbilen, Merve Suzan Zeden, and Ender Volkan. "FimH and Type 1 Pili Mediated Tumor Cell Cytotoxicity by Uropathogenic Escherichia coli In Vitro." Pathogens 12, no. 6 (2023): 751. http://dx.doi.org/10.3390/pathogens12060751.

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Uropathogenic Escherichia coli express hairlike proteinaceous surface projections, known as chaperone–usher pathway (CUP) pili. Type 1 pili are CUP pili with well-established pathogenic properties. The FimH adhesin subunit of type 1 pili plays a key role in the pathogenesis of urinary tract infections (UTIs) as it mediates the adhesion of the bacteria to urothelial cells of the bladder. In this study, two breast cancer cell lines, MDA-MB-231 and MCF-7, were used to demonstrate the cytotoxic activities of type 1 piliated uropathogenic E. coli UTI89 on breast cancer cells in a type 1 pili and Fi

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27

Sherman, P., R. Soni, and E. Boedeker. "Role of Type 1 Somatic Pili (Fimbriae) in Mucosal Attachment of the Enteroadherent Escherichia coli, Strain RDEC‐1, in Rabbits." Journal of Pediatric Gastroenterology and Nutrition 7, no. 4 (1988): 594–601. http://dx.doi.org/10.1002/j.1536-4801.1988.tb09597.x.

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Summary:We have previously shown that attachment of the rabbit enteroadherent Escherichia coli, strain RDEC‐1, to ileal brush borders in vitro is mediated by both man‐nose‐resistant, AF/R1 pili and mannose‐sensitive, type 1 pili. Because the role of type 1, somatic pili as adhesins that mediate bacterial enteroadherence in vivo remains controversial, we examined adherence of RDEC‐1 expressing either type 1 pili or AF/R1 pili to rabbit ileum in ligated loops and after oral infection of rabbits. A rabbit fecal commensal E. coli, 640, which also expressed type 1 pili was used as a control. After

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28

Persat, Alexandre, Yuki F. Inclan, Joanne N. Engel, Howard A. Stone, and Zemer Gitai. "Type IV pili mechanochemically regulate virulence factors inPseudomonas aeruginosa." Proceedings of the National Academy of Sciences 112, no. 24 (2015): 7563–68. http://dx.doi.org/10.1073/pnas.1502025112.

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Bacteria have evolved a wide range of sensing systems to appropriately respond to environmental signals. Here we demonstrate that the opportunistic pathogenPseudomonas aeruginosadetects contact with surfaces on short timescales using the mechanical activity of its type IV pili, a major surface adhesin. This signal transduction mechanism requires attachment of type IV pili to a solid surface, followed by pilus retraction and signal transduction through the Chp chemosensory system, a chemotaxis-like sensory system that regulates cAMP production and transcription of hundreds of genes, including k

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29

Claret, Laurent, Sylvie Miquel, Natacha Vieille, Dmitri A. Ryjenkov, Mark Gomelsky, and Arlette Darfeuille-Michaud. "The Flagellar Sigma Factor FliA Regulates Adhesion and Invasion of Crohn Disease-associated Escherichia coli via a Cyclic Dimeric GMP-dependent Pathway." Journal of Biological Chemistry 282, no. 46 (2007): 33275–83. http://dx.doi.org/10.1074/jbc.m702800200.

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The invasion of intestinal epithelial cells by the Crohn disease-associated adherent-invasive Escherichia coli (AIEC) strain LF82 depends on surface appendages, such as type 1 pili and flagella. The absence of flagella in the AIEC strain LF82 results in a concomitant loss of type 1 pili. Here, we show that flagellar regulators, transcriptional activator FlhD2C2, and sigma factor FliA are involved in the coordination of flagellar and type 1 pili synthesis. In the deletion mutants lacking these regulators, type 1 pili synthesis, adhesion, and invasion were severely decreased. FliA expressed alon

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Mu, Xiang-Qi, Edward H. Egelman, and Esther Bullitt. "Structure and Function of Hib Pili from Haemophilus influenzae Type b." Journal of Bacteriology 184, no. 17 (2002): 4868–74. http://dx.doi.org/10.1128/jb.184.17.4868-4874.2002.

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ABSTRACT Pathogenic bacteria are specifically adapted to bind to their customary host. Disease is then caused by subsequent colonization and/or invasion of the local environmental niche. Initial binding of Haemophilus influenzae type b to the human nasopharynx is facilitated by Hib pili, filaments expressed on the bacterial surface. With three-dimensional reconstruction of electron micrograph images, we show that Hib pili comprise a helix 70 Å in diameter with threefold symmetry. The Hib pilus filament has 3.0 subunits per turn, with each set of three subunits translated 26.9 Å along and rot

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Meng, Yizhi, Yaxin Li, Cheryl D. Galvani, et al. "Upstream Migration of Xylella fastidiosa via Pilus-Driven Twitching Motility." Journal of Bacteriology 187, no. 16 (2005): 5560–67. http://dx.doi.org/10.1128/jb.187.16.5560-5567.2005.

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ABSTRACT Xylella fastidiosa is a xylem-limited nonflagellated bacterium that causes economically important diseases of plants by developing biofilms that block xylem sap flow. How the bacterium is translocated downward in the host plant's vascular system against the direction of the transpiration stream has long been a puzzling phenomenon. Using microfabricated chambers designed to mimic some of the features of xylem vessels, we discovered that X. fastidiosa migrates via type IV-pilus-mediated twitching motility at speeds up to 5 μm min−1 against a rapidly flowing medium (20,000 μm min−1). Ele

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32

Shoji, Mikio, Satoshi Shibata, Takayuki Sueyoshi, Mariko Naito, and Koji Nakayama. "Biogenesis of Type V pili." Microbiology and Immunology 64, no. 10 (2020): 643–56. http://dx.doi.org/10.1111/1348-0421.12838.

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33

Leang, Ching, Xinlei Qian, Tünde Mester, and Derek R. Lovley. "Alignment of the c-Type Cytochrome OmcS along Pili of Geobacter sulfurreducens." Applied and Environmental Microbiology 76, no. 12 (2010): 4080–84. http://dx.doi.org/10.1128/aem.00023-10.

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ABSTRACT Immunogold localization revealed that OmcS, a cytochrome that is required for Fe(III) oxide reduction by Geobacter sulfurreducens, was localized along the pili. The apparent spacing between OmcS molecules suggests that OmcS facilitates electron transfer from pili to Fe(III) oxides rather than promoting electron conduction along the length of the pili.

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Liu, Xing, Pier-Luc Tremblay, Nikhil S. Malvankar, Kelly P. Nevin, Derek R. Lovley, and Madeline Vargas. "A Geobacter sulfurreducens Strain Expressing Pseudomonas aeruginosa Type IV Pili Localizes OmcS on Pili but Is Deficient in Fe(III) Oxide Reduction and Current Production." Applied and Environmental Microbiology 80, no. 3 (2013): 1219–24. http://dx.doi.org/10.1128/aem.02938-13.

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ABSTRACTThe conductive pili ofGeobacterspecies play an important role in electron transfer to Fe(III) oxides, in long-range electron transport through current-producing biofilms, and in direct interspecies electron transfer. Although multiple lines of evidence have indicated that the pili ofGeobacter sulfurreducenshave a metal-like conductivity, independent of the presence ofc-type cytochromes, this claim is still controversial. In order to further investigate this phenomenon, a strain ofG. sulfurreducens, designated strain PA, was constructed in which the gene for the native PilA, the structu

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35

Wall, Daniel, Samuel S. Wu, and Dale Kaiser. "Contact Stimulation of Tgl and Type IV Pili inMyxococcus xanthus." Journal of Bacteriology 180, no. 3 (1998): 759–61. http://dx.doi.org/10.1128/jb.180.3.759-761.1998.

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ABSTRACT Myxococcus xanthus tgl mutants lack social motility and type IV pili but can be transiently stimulated to swarm and to make pili by contacting tgl + cells. The absence of pili in tgl mutants is shown not to be due to the absence of pilin. The rate of pilus elongation after Tgl stimulation is shown to be similar to the rate of pilus elongation in wild-type cells, using a new more rapid assay for stimulation.

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36

De La Fuente, Leonardo, Thomas J. Burr, and Harvey C. Hoch. "Autoaggregation of Xylella fastidiosa Cells Is Influenced by Type I and Type IV Pili." Applied and Environmental Microbiology 74, no. 17 (2008): 5579–82. http://dx.doi.org/10.1128/aem.00995-08.

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ABSTRACT Autoaggregation of widely dispersed Xylella fastidiosa cells into compact cell masses occurred over a period of hours following 7 to 11 days of growth in microfluidic chambers. Studies involving the use of mutants defective in polarly positioned type I (fimA-negative), type IV (pilB-negative), or both type I and IV (fimA- and pilO-negative) pili revealed the importance and role of pili in the autoaggregation process.

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Vignon, Guillaume, Rolf Köhler, Eric Larquet, et al. "Type IV-Like Pili Formed by the Type II Secreton: Specificity, Composition, Bundling, Polar Localization, and Surface Presentation of Peptides." Journal of Bacteriology 185, no. 11 (2003): 3416–28. http://dx.doi.org/10.1128/jb.185.11.3416-3428.2003.

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ABSTRACT The secreton or type II secretion machinery of gram-negative bacteria includes several type IV pilin-like proteins (the pseudopilins) that are absolutely required for secretion. We previously reported the presence of a bundled pilus composed of the pseudopilin PulG on the surface of agar-grown Escherichia coli K-12 cells expressing the Klebsiella oxytoca pullulanase (Pul) secreton genes at high levels (N. Sauvonnet, G. Vignon, A. P. Pugsley, and P. Gounon, EMBO J. 19:2221-2228, 2000). We show here that PulG is the only pseudopilin in purified pili and that the phenomenon is not restri

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Jenkins, A. Toby A., Angus Buckling, Marsha McGhee, and Richard H. ffrench-Constant. "Surface plasmon resonance shows that type IV pili are important in surface attachment by Pseudomonas aeruginosa." Journal of The Royal Society Interface 2, no. 3 (2005): 255–59. http://dx.doi.org/10.1098/rsif.2005.0030.

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Type IV pili have been shown to play a role in the early stages of bacterial biofilm formation, but not in initial bacterial attachment. Here, using the surface analytical technique, surface plasmon resonance (SPR), we follow the attachment of the bacterium Pseudomonas aeruginosa in real time. In contrast to previous studies, we show that type IV pili mutants are defective in attachment. Both mutants lacking pili ( pilA ), and those possessing an overabundance of pili ( pilT ), showed reduced SPR measured attachment compared with the wild-type PAO1 strain. Both pil mutants also showed reduced

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Jacobsen, Theis, Benjamin Bardiaux, Olivera Francetic, Nadia Izadi-Pruneyre, and Michael Nilges. "Structure and function of minor pilins of type IV pili." Medical Microbiology and Immunology 209, no. 3 (2019): 301–8. http://dx.doi.org/10.1007/s00430-019-00642-5.

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AbstractType IV pili are versatile and highly flexible fibers formed on the surface of many Gram-negative and Gram-positive bacteria. Virulence and infection rate of several pathogenic bacteria, such as Neisseria meningitidis and Pseudomonas aeruginosa, are strongly dependent on the presence of pili as they facilitate the adhesion of the bacteria to the host cell. Disruption of the interactions between the pili and the host cells by targeting proteins involved in this interaction could, therefore, be a treatment strategy. A type IV pilus is primarily composed of multiple copies of protein subu

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Touhami, Ahmed, Manfred H. Jericho, Jessica M. Boyd, and Terry J. Beveridge. "Nanoscale Characterization and Determination of Adhesion Forces of Pseudomonas aeruginosa Pili by Using Atomic Force Microscopy." Journal of Bacteriology 188, no. 2 (2006): 370–77. http://dx.doi.org/10.1128/jb.188.2.370-377.2006.

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ABSTRACT Type IV pili play an important role in bacterial adhesion, motility, and biofilm formation. Here we present high-resolution atomic force microscopy (AFM) images of type IV pili from Pseudomonas aeruginosa bacteria. An individual pilus ranges in length from 0.5 to 7 μm and has a diameter from 4 to 6 nm, although often, pili bundles in which the individual filaments differed in both length and diameter were seen. By attaching bacteria to AFM tips, it was possible to fasten the bacteria to mica surfaces by pili tethers. Force spectra of tethered pili gave rupture forces of 95 pN. The slo

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Aagesen, Alisha M., Sureerat Phuvasate, Yi-Cheng Su, and Claudia C. Häse. "Persistence of Vibrio parahaemolyticus in the Pacific Oyster, Crassostrea gigas, Is a Multifactorial Process Involving Pili and Flagella but Not Type III Secretion Systems or Phase Variation." Applied and Environmental Microbiology 79, no. 10 (2013): 3303–5. http://dx.doi.org/10.1128/aem.00314-13.

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ABSTRACTVibrio parahaemolyticuscan resist oyster depuration, suggesting that it possesses specific factors for persistence. We show that type I pili, type IV pili, and both flagellar systems contribute toV. parahaemolyticuspersistence in Pacific oysters whereas type III secretion systems and phase variation do not.

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Carty, Helen, and Donald G. Shaw. "Osteogenesis Imperfecta Type IVA." Acta Paediatrica 77, no. 5 (1988): 752–53. http://dx.doi.org/10.1111/j.1651-2227.1988.tb10742.x.

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Paterson, C. R., S. J. McAllion, and J. W. Shaw. "Osteogenesis lmperfecta Type IVA." Acta Paediatrica 77, no. 5 (1988): 753–54. http://dx.doi.org/10.1111/j.1651-2227.1988.tb10743.x.

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Hasegawa, Y. "Phakomatosis pigmentovascularis type IVa." Archives of Dermatology 121, no. 5 (1985): 651–55. http://dx.doi.org/10.1001/archderm.121.5.651.

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Hasegawa, Yoshihiro. "Phakomatosis Pigmentovascularis Type IVa." Archives of Dermatology 121, no. 5 (1985): 651. http://dx.doi.org/10.1001/archderm.1985.01660050103025.

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Taguchi, Fumiko, and Yuki Ichinose. "Role of Type IV Pili in Virulence of Pseudomonas syringae pv. tabaci 6605: Correlation of Motility, Multidrug Resistance, and HR-Inducing Activity on a Nonhost Plant." Molecular Plant-Microbe Interactions® 24, no. 9 (2011): 1001–11. http://dx.doi.org/10.1094/mpmi-02-11-0026.

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To investigate the role of type IV pili in the virulence of phytopathogenic bacteria, four mutant strains for pilus biogenesis-related genes were generated in Pseudomonas syringae pv. tabaci 6605. PilA encodes the pilin protein as a major subunit of type IV pili, and the pilO product is reported to be required for pilus assembly. The fimU and fimT genes are predicted to produce minor pilins. Western blot analysis revealed that pilA, pilO, and fimU mutants but not the fimT mutant failed to construct type IV pili. Although the swimming motility of all mutant strains was not impaired in liquid me

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Karuppiah, Vijaykumar, and Jeremy P. Derrick. "Type IV pili—a numbers game." EMBO Journal 33, no. 16 (2014): 1732–34. http://dx.doi.org/10.15252/embj.201489096.

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Kåhrström, Christina Tobin. "Type IV pili function as mechanosensors." Nature Reviews Microbiology 13, no. 7 (2015): 399. http://dx.doi.org/10.1038/nrmicro3517.

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Mattick, John S. "Type IV Pili and Twitching Motility." Annual Review of Microbiology 56, no. 1 (2002): 289–314. http://dx.doi.org/10.1146/annurev.micro.56.012302.160938.

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Ruiz-Villaverde, R., A. Villanova-Mateu, R. Ortega del Olmo, and D. Sanchez-Cano. "Pseudomonilethrix type II and pili bifurcati." Journal of the European Academy of Dermatology and Venereology 20, no. 7 (2006): 889–90. http://dx.doi.org/10.1111/j.1468-3083.2006.01564.x.

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