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Relevant bibliographies by topics / Piperazin

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Academic literature on the topic 'Piperazin'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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Journal articles on the topic "Piperazin"

1

Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were

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Prabawati, Susy Yunita. "SYNTHESIS OF 1,4-BIS [(1-HYDROXY-4-T-BUTYL-PHENYL) METHYL]PIPERAZINE AS ANTIOXIDANTS." Molekul 11, no. 2 (2016): 220. http://dx.doi.org/10.20884/1.jm.2016.11.2.244.

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A study has been conducted to synthesize 1,4-bis [(1-hydroxy-4-t-butyl-phenyl)-methyl]piperazin using phenol derivate and investigate the capability of that compound, as an antioxidant. The synthesis was carried out through Mannich reaction using p-t-butylphenol, paraformaldehyde, and piperazine. The product was characterized by IR and 1H NMR spectroscopic. Testing of antioxidant activity was done with the immersion of DPPH (1,1-diphenyl-2 picrylhydrazyl) free radical method. The product was obtained as a white solid, with a point of 252,7-254,7 ºC and a yield of 65.76%. The test of antioxidan

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Song, Yanxi, C. S. Chidan Kumar, G. B. Nethravathi, S. Naveen, and Hongqi Li. "Cinnarizinium picrate." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1747. http://dx.doi.org/10.1107/s1600536812020764.

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In the title salt {systematic name: 4-diphenylmethyl-1-[(E)-3-phenylprop-2-en-1-yl]piperazin-1-ium 2,4,6-trinitrophenolate), C26H29N2 +·C6H2N3O7 −, the cinnarizinium cation is protonated at the piperazine N atom connected to the styrenylmethyl group; the piperazine ring adopts a distorted chair conformaiton. In the crystal, bifurcated N—H...(O,O) hydrogen bonds link the components into two-ion aggregates.

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Verma, Arvind Kumar, Arun Kumar, and Kunwar Abhishek Singh. "Synthesis and molecular docking for anticonvulsant activity of some new benzoxazole derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 551. https://doi.org/10.59467/ijhc.2025.35.551.

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To explore the anticonvulsant action related to the benzoxazole framework, a series of benzoxazole-piperazine derivatives, namely N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-(piperazin-1-yl) acetamides (3a-e) (3), was synthesized by reacting N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-chloroacetamide (2) with various substituted piperazines. Molecular docking studies were conducted using Auto Dock Vina 1.5.7 to evaluate the compounds' binding affinities with anticonvulsant-related targets protein data bank ID: 3PO7, 7WLJ, using zonisamide as a standard drug to ensure their potential. Several compounds exhibit

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Al-Soud, Yaseen, Najim Al-Masoudi, Hamed Hassan, Erik De Clercq, and Christophe Pannecouque. "Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivatives." Acta Pharmaceutica 57, no. 4 (2007): 379–93. http://dx.doi.org/10.2478/v10007-007-0031-7.

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Nitroimidazoles. V. Synthesis and anti-HIV evaluation of new 5-substituted piperazinyl-4-nitroimidazole derivativesA series of 2-alkylthio-1-[4-(1-benzyl-2-ethyl-4-nitro-1H- -imidazol-5-yl)-piperazin-1-y]lethanones (3-9) and alkyl- [4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)-piperazin- -1-yl)ketones (11-20) as well as the indole analogue22were synthesized from 4-nitro-5-piperazinyl imidazole derivative1, with the aim to develop newly non-nucleoside reverse transcriptase inhibitors (NNRTIs). The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compound2showed i

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Erdag, Emine. "A New Tick on the Clock: Indole-Based Optimization of Melatonin Receptor Modulators." Chronobiology in Medicine 7, no. 2 (2025): 88–94. https://doi.org/10.33069/cim.2025.0014.

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Objective: Melatonin is a key regulator of circadian rhythms and sleep-wake cycles, exerting its effects through MT1 and MT2 receptors. Despite the clinical use of selective MT1/MT2 agonists, their short half-lives, low bioavailabilities, and rapid first-pass metabolism limit their efficacy in sleep and circadian rhythm disorders. This study aimed to identify and evaluate novel piperazine-substituted indole derivatives with enhanced receptor binding, prolonged systemic circulation, and improved pharmacokinetic properties as potential next-generation melatonin receptor modulators.Methods: Seven

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Hakimi, Mohammad, Zahra Mardani, Keyvan Moeini, Esther Schuh, and Fabian Mohr. "A Spectral and Structural Study of the New Cadmium Salt [(H2L)2][Cd2I6][(NO3)2]." Zeitschrift für Naturforschung B 68, no. 3 (2013): 272–76. http://dx.doi.org/10.5560/znb.2013-2295.

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The reaction between 2-(piperazin-1-yl)ethanol and cyclohexene oxide under microwave irradiation gave 2-(4-(2-hydroxyethyl)piperazin-1-yl)cyclohexanol (L). The new cadmium salt [(H2L)2][Cd2I6][(NO3)2] (1) was prepared from the reaction of cadmium iodide with L and identified by elemental analysis, FT-IR and Raman spectroscopy, and single-crystal X-ray diffraction. In the crystal structure of 1, there is a [Cd2I6]2- dianion with distorted tetrahedral geometry for each cadmium atom. The piperazine and cyclohexane rings in 1 have a chair conformation. In the crystal there are several intermolecul

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Sati, Nitin, Sushil Kumar, and Sushil Sati. "Synthesis and Pharmacological Evaluation of 7-{2-[4-(Substituted phenyl)-piperazin-1-yl]-2-Oxo-Ethoxy}-4-Methyl-Chromen-2-Ones as Serotonin 5-HT2 Receptors Antagonist." International Journal of Drug Design and Discovery 2, no. 1 (2024): 419–24. https://doi.org/10.37285/ijddd.2.1.9.

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Substitutedphenyl piperazines were treated with chloroacetylchloride to give respective 2-chloro-1-[4-(substitutedphenyl)-piperazin-1-yl]-ethanones which were subsequently coupled to 7-hydroxy-4-methyl-chromen-2-one to afford the target compounds 7-{2-[4-(substituted phenyl)-piperazin-1-yl]-2-oxo-ethoxy}-4-methyl-chromen-2-ones. The novel compounds were evaluated in-vivo for antagonism at serotonin 5-HT2 receptor. Some of the compounds synthesized showed high antagonistic activity for the target receptor. The binding affinity to these receptors depended greatly on the nature and position of su

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Hussien, Nasry Jassim, Jasim M. S. Alshawi, Khalid Tuama Abdullah, Enaam I. Yousif, and Mohamad J. Al-Jeboori. "Dimethyltin (IV) complexes of new thiosemicarbazone ligand with piperazine-1-yimethylene moiety: Synthesis, spectral characterization and antibacterial activity." Edelweiss Applied Science and Technology 9, no. 3 (2025): 266–78. https://doi.org/10.55214/25768484.v9i3.5202.

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Three new thiosemicarbazone ligands and their dimethyltin (IV) complexes are reported. The condensation of piperazine-1-carbaldehyde with thiosemicarbazide, 4-methyl-3-thiosemicarbazide, and 4-ethyl-3-thiosemicarbazide was carried out in an ethanol medium using HBr as a catalyst, resulting in the isolation of the ligands (E)-2-(piperazin-1-ylmethylene) hydrazine-1-carbothioamide (HL1), (E)-N-methyl-2-(piperazin-1-ylmethylene) hydrazine-1-carbothioamide (HL2), and (E)-N-ethyl-2-(piperazin-1-ylmethylene) hydrazine-1-carbothioamide (HL3), respectively. The reaction of ligands HL1 - HL3 with dimet

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Sonkamble, Sneh D., Dinesh D. Rishipathak, Laxman A. Kawale, and Vandana S. Nade. "DESIGN, SYNTHESIS AND EVALUATION OF CNS DEPRESSANT ACTIVITY OF 2-(SUBSTITUTED ARYL)-PIPERAZINE-3-PHENYL-4(3H)-QUINAZOLINONE." International Journal of Pharmaceutical Sciences and Drug Research 15, no. 02 (2023): 209–13. http://dx.doi.org/10.25004/ijpsdr.2023.150213.

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Anxiety is characterized by excessive fear that persists and interferes with a person's daily activities. In this study, a new class of 16 derivatives of 2-(Substituted Aryl)-piperazine-3-phenyl-4(3H)-quinazolinones were synthesized, and all of the derivatives were tested for their ability to reduce anxiety using the holeboard test and the elevated plus maize test, administered intraperitoneally to mice at doses of 10 mg/kg body weight. Test compounds 3-phenyl-2-(4-(3-methylphenyl) piperazin-1-yl)quinazolin-4(3H)-one (SD-05), 2-(4-(2-fluorophenyl) piperazin-1-yl)-3-phenylquinazolin-4(3H)-one (

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Dissertations / Theses on the topic "Piperazin"

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Ermatchkov, Viktor. "Phasengleichgewichte in komplexen, chemisch reagierenden Systemen NH3 + SO2 + H2O + Salze und CO2 + H2O + MDEA, Piperazin /." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980777488.

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Wierschem, Frank Georg. "Darstellung und Modifizierung von 2-Oxo-piperazin-basierenden Isoxazolinen und Isoxazolidinen in Lösung und an fester Phase." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971626812.

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Schinina', Barbara. "Progettazione, sintesi e valutazione farmacologica di derivati del 4-nitro-7-piperazin-1-il-2,1,3-benzossadiazolo come nuovi ligandi sigma fluorescenti." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1173.

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Da sempre biologi e biochimici hanno focalizzato la loro attenzione in numerosi studi volti a chiarire i processi e le strutture molecolari fondamentali per la vita. Tra le tecnologie utilizzate allo scopo di conoscere la struttura di una biomolecola e la sua interazione con altre strutture, la diffrazione a raggi X, la risonanza magnetica nucleare ela microscopia elettronica permettono misure che richiedono grandi quantit¨¤ di composti purificati, sono spesso eseguite in condizioni non-fisiologiche e sono raramente adatte per osservare le reazioni molecolari in tempo reale. Recenti sviluppi s

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Moura, Rebeca Garcia. "Síntese de um fragmento precursor do Indinavir." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-11042017-075910/.

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Considerando-se a necessidade brasileira de se obterem fármacos a preços competitivos e usando tecnologia nacional, visamos sintetizar um fragmento do Indinavir empregando como material de partida a L-serina, um aminoácido natural de baixo custo. Desta maneira, desenvolvemos a seguinte rota, em 6 etapas: p-tosilação da serina, pelo uso de cloreto de p-tosila / NaOH; amidação da p-tosilserina, empregando-se o sal de terc-butilamônio da N-hidroxissuccinimida / DCC; ciclização da (S)-2-terc-butil-N-p-tosilserina, em condição de transferência de fase, com cloreto de p-tosila / carbonato de potássi

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Gunay, Neset Batuhan. "Studies Directed Towards The Synthesis Of Imatinib Mesylate ((gleevec), 4-(4-methyl-piperazin-1- Ylmethyl)-n-[4- Methyl-3-(4-pyridin-3-yl-pyrimidin-2- Ylamino)-phenyl]- Benzamide Methanesulfonate) Analogs." Master's thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/12610181/index.pdf.

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Imatinib mesylate is indicated for the treatment of chronic myeloid leukemia (CML) and unresectable and/or metastatic malignant gastrointestinal stromal tumors (GIST). By the application of this anticancer drug, problems occurs in terms of stability and activity. Computer assisted design (CAD) works showed that the modification of the B and C part molecule can increase the effectivity of the drug. The new derivatives of the drug will be obtained to change some part of the B and C segments. The total synthesis of a new imatinib mesylate will be done and the activity tests are going to be determ

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Khan, Abdul Majeed 1980. "Síntese e termoquímica de adutos de brometos de metais bivalentes com aminas hetrocíclicas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249123.

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Orientador: Pedro Oliver Dunstan Lozano<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T07:28:40Z (GMT). No. of bitstreams: 1 Khan_AbdulMajeed_D.pdf: 3004508 bytes, checksum: 1d8c778094bf0cb1b93fa7bf80e19074 (MD5) Previous issue date: 2013<br>Resumo: Os adutos MX2.nL (M = Mn, Fe, Co, Ni, Cu ou Zn, L = 3-cianopiridina, piperidina ou piperazaina, X = Br, n = 0,5, 0,75, 1, 1,5, 2 ou 4), foram sintetizados e caracterizados através de análise elementar, determinação de pontos de fusão, espectroscopia IV e eletrônica e análise

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Viana, Fernando AndrÃ Campos. "Estudo comparativo, randomizado para avaliar a eficÃcia terapÃutica da piperazina hexahidratada com extrato fluido de rhamnus purshiana no tratamento da ascaridÃase." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=646.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A eficÃcia e a seguranÃa terapÃutica de um medicamento a base de piperazina hexahidratada associada com o extrato fluido de Rhamnus purshiana (DM IndÃstria FarmacÃutica) usada como tratamento anti-helmÃntico em pacientes no CearÃ, Brasil, foi testado em comparaÃÃo com o produto composto de piperazina sem qualquer associaÃÃo (DM IndÃstria FarmacÃutica). Um estudo prospectivo, randomizado, controlado e duplo cego, comparando taxas de cura para infecÃÃo por Ascaris lunbricoides. Amostras coprolÃgicas de 990 pacientes foram coletadas

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Vasconcelos, Leonardo de. "Síntese de um fragmento precursor do fármaco Indinavir." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-23042013-141617/.

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Neste trabalho foram aprofundados nossos estudos para obtenção da (S)-2-terc-butilamida-4-(3-picolil)piperazina, pela abertura da (S)-2-terc-butilcarboxamida-N-p-tosilaziridina seguida de ciclização, em 78% de rendimento, com o triflato de vinildifenilsulfônio. A aziridina foi preparada por um processo de ciclização, em condições de transferência de fase, partindo-se da L-serina, um aminoácido natural de baixo custo. Esta rota sintética rendeu um material que apresenta a mesma estereoquímica S do fragmento piperazínico usado na síntese do Indinavir, podendo vir a constituir uma via alternativa

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González, Lira Christian Guillermo. "Estudio de Funcionalización de la (4-Nitro-Fenil)-1-Piperazina Orientada a la Síntesis de (4,7-Dimetoxi-Benzo[b]Tiofen-2-Carbonil) Piperazinil Arilbenzamidas como Potenciales Ligandos Serotoninérgicos." Tesis, Universidad de Chile, 2007. http://www.repositorio.uchile.cl/handle/2250/105666.

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Memoria para optar al título de Químico<br>Las arilpiperazinas constituyen una familia de compuestos de interés en el ámbito neurofarmacológico principalmente por sus acciones ansiolíticas y antidepresivas, a través de interacciones con el receptor serotoninérgico 5-HT1A. El presente trabajo de tesis informa de la síntesis de una serie de compuestos benzotiofenarilpiperazínicos 10 (a-f) adecuadamente funcionalizados. El acceso sintético a esta serie tiene lugar a través de una secuencia de 6 pasos a partir de 3,6-dimetoxi-2-nitrobenzaldehído con tioglicolato de metilo en medio básico. Como p

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Monaghan, S. M. "Synthetic studies in the piperazine-2,5-dione area." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47304.

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Books on the topic "Piperazin"

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Kagaku Busshitsu Hyōka Kenkyū Kikō and Shin Enerugī Sangyō Gijutsu Sōgō Kaihatsu Kikō (Japan), eds. Piperajin: Piperazine. Seihin Hyōka Gijutsu Kiban Kikō Kagaku Busshitsu Hyōka Kenkyū Kikō, 2007.

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Attorney-General, New Zealand. Report of the Attorney-General under the New Zealand Bill of Rights Act 1990 on the Misuse of Drugs (Classification of BZP) Amendment Bill 2007. House of Representatives, 2007.

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Great Britain. Health and Safety Executive. Occupational Medicine and Hygiene Laboratory. Organic isocyanates in air: Laboratory method using 1-(2-methoxyphenyl) piperazine solution and high performance liquid chromatography. HSE Books, 1994.

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Occupational Medicine and Hygiene Laboratory. Organic isocyanates in air: Laboratory method using 1-(2-methoxyphenyl) piperazine solution and high performance liquid chromatography. Health and Safety Executive, 1987.

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Sedefov, Roumen. Report on the risk assessment of BZP in the framework of the Council decision on new psychoactive substances. Office for Official Publications of the European Communities, 2009.

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1935-, Gingell Clive, ed. Management of ED: Focus on sildenafil : a urologist's approach. PharmaLibri, 1998.

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J, Fowler Clare, ed. Management of ED: Focus on sildenafil : a neurologist's approach. PharmaLibri, 1999.

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Botz-Bornstein, Thorsten. The philosophy of Viagra: Bioethical responses to the viagrification of the modern world. Rodopi, 2011.

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Weigl, Manuela. Synthese und Struktur/Wirkungsbeziehungen überbrückter Piperazin-Derivate. 2001.

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Bedürftig, Stephan. Mono- und bicyclische Piperazin-Derivate aus (S)-Serin: Synthese und Beziehungen zwischen Struktur und [sigma]-Rezeptoraffinität. 2003.

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Book chapters on the topic "Piperazin"

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Meyer, H. H., and P. Brenner. "Spalthand- und Spaltfußmißbildung als eine mögliche teratogene Nebenwirkung des Anthelmintikums Piperazin?" In Der Internist. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-662-39609-4_29.

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de Groot, Anton C. "Piperazine." In Monographs In Contact Allergy. CRC Press, 2022. http://dx.doi.org/10.1201/9781003158004-391.

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Pardasani, R. T., and P. Pardasani. "Magnetic properties of binuclear copper(II) complex with {2, 6-bis[(N-methyl-piperazin-1-yl)methyl]-4-bromophenol}." In Magnetic Properties of Paramagnetic Compounds. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-53974-3_308.

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Stark, Margaret, Jason Payne-James, and Michael Scott-Ham. "Piperazines." In Symptoms and Signs of Substance Use, 4th ed. Routledge, 2025. https://doi.org/10.4324/9781003381730-29.

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Hirota, E., K. Kuchitsu, T. Steimle, J. Vogt, and N. Vogt. "116 C4H10N2 Piperazine." In Molecules Containing Three or Four Carbon Atoms and Molecules Containing Five or More Carbon Atoms. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41504-3_117.

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Alicante, Raquel. "Piperazine Azopolymer Thin Films." In Springer Theses. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31756-9_4.

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Laux, Gerd. "Piperazine Phenothiazines: Fluphenazine and Perphenazine." In NeuroPsychopharmacotherapy. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62059-2_474.

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Eller, Sarah, and Marcelo Dutra Arbo. "Piperazine Designer Drugs of Abuse." In Handbook of Substance Misuse and Addictions. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92392-1_166.

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Laux, Gerd. "Piperazine Phenothiazines: Fluphenazine and Perphenazine." In NeuroPsychopharmacotherapy. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-56015-1_474-1.

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Eller, Sarah, and Marcelo Dutra Arbo. "Piperazine Designer Drugs of Abuse." In Handbook of Substance Misuse and Addictions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67928-6_166-1.

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Conference papers on the topic "Piperazin"

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Akkor, Ilayda, Shachit S. Iyer, John Dowdle, Le Wang, and Chrysanthos Gounaris. "Economic Optimization and Impact of Utility Costs on the Optimal Design of Piperazine-Based Carbon Capture." In Foundations of Computer-Aided Process Design. PSE Press, 2024. http://dx.doi.org/10.69997/sct.147100.

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Recent advances in process design for solvent-based, post-combustion capture (PCC) processes, such as the Piperazine/Advanced Flash Stripper (PZ/AFS) process, have led to a reduction in the energy required for capture. Even though PCC processes are progressively improving in Technology Readiness Levels (TRL), with a few commercial installations, incorporating carbon capture adds cost to any operation. Hence, cost reduction will be instrumental for proliferation. The aim of this work is to improve process economics through optimization and to identify the parameters in our economic model that h

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Huang, Shengyuan, Olajide Otitoju, Yao Zhang, and Meihong Wang. "Technical Assessment of direct air capture using piperazine in an advanced solvent-based absorption process." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.124483.

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Climate and environmental problems caused by increasing CO2 concentration in the atmosphere make the direct air capture (DAC) technology having great prospects for development. As the widely used solvent in carbon capture based on chemical absorption processes, MEA still fails to address the issues of high energy consumption and high costs when used in DAC process. In this study, piperazine (PZ) was used as the new solvent for DAC process. The new configuration was simulated in Aspen Plus� V11 and the model was validated through experimental data and model comparison. It is followed by investi

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Peng, Lei, Qiang Fu, Zhi Li, Musong Lin, Yaohong Zhao, and Zaikun Wu. "Investigate of mass transfer of CO2 absorption into the mixed solution of piperazine and diethanolamine in a packed column." In Fifth International Conference on Green Energy, Environment, and Sustainable Development, edited by Mohammadreza Aghaei, Hongyu Ren, and Xiaoshuan Zhang. SPIE, 2024. http://dx.doi.org/10.1117/12.3044925.

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Andrić, Deana B., Slađana Dukić-Stefanovic, Jelena Z. Penjišević, et al. "DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL N- {4-[2-(4-ARYL-PIPERAZIN-1-YL)-ETHYL]-PHENYL}-ARYLAMIDES." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.355a.

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5HT1A receptor targeting drugs have been used as the treatment for the many neuropsychiatric disorders, such as schizophrenia and depression. As a part of ongoing research, we designed series of new compounds that share arylpiperazine common structural motif with the 5HT1A receptor ligand aripiprazole. Receptor-ligand interactions were determined by the molecular docking simulations, revealing the positive impact of the phenyl substitution in the arylpiperazine part of the molecules. Nine selected compounds were synthesized in four reaction steps in high overall yields (59-73%). In vitro pharm

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Renk, D., M. Holschbach, D. Bier, and B. Neumaier. "Synthese von Aminobenzothiazolderivaten mit unterschiedlichen fluorhaltigen Piperidin- und Piperazin-Substituenten für die PET-Bildgebung des Adenosin-A 2A -Rezeptors." In NuklearMedizin 2020. © Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0040-1708273.

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Ananth, Arjun H., and Senthamaraikannan Kabilan. "Synthesis, In Silico and In Vitro Studies of 7-Methxy-3-((4-phenyl piperazin-1-yl)methyl)-2H-chromen-2-one Analogues as Derivatives as Anti-Prostate Cancer Agents." In ECMC 2022. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13179.

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Pazdera, P., B. Andělová, and D. Němečková. "Utilization of piperazine for interphase catalytic systems." In The 13th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00192.

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Loupias, Pauline, Alexandra Dassonville-Klimpt, Elodie Lohou, Nicolas Taudon, and Pascal Sonnet. "Trojan horse strategy: synthesis of piperazine-based siderophores." In 4th International Electronic Conference on Medicinal Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05579.

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Zhang, Xiaoguang, Xuexing Chen, Qingchun Chen, et al. "Preparation and Co (II) Removal of ZnO/Poly-Piperazineamide Nanofiltration Membranes." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-67740.

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A series of nanofiltration membranes were prepared by interfacial polymerization of piperazine and terephthaloyl chloride on the surface of polyacrylonitrile (PAN) ultrafiltration membranes. ZnO nanoparticles were incorporated in the active separation layer to modify the performances of the membranes. The preparation conditions as the monomer concentration, dosage of nano-ZnO particles and the reaction time on removal of a simulated radioactive nuclide Co (II) were investigated. Fourier transform infrared in attenuated total reflection mode verified the formation of polyamide on the PAN ultraf

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Xiang, Haoyue, Xiang Wang, Yanhong Chen, et al. "Abstract LB-268: Discovery of clinical candidate methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) : A highly potent and selective PI3K alpha inhibitor for the treatment of advanced solid tumors." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-lb-268.

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Reports on the topic "Piperazin"

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Rochelle, Gary, Fred Closmann, Jorge Martorell, et al. Front-End Engineering Design for Piperazine with the Advanced Stripper. Office of Scientific and Technical Information (OSTI), 2022. http://dx.doi.org/10.2172/1878608.

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John T. Cullinane. THERMODYNAMICS AND KINETICS OF AQUEOUS PIPERAZINE WITH POTASSIUM CARBONATE FOR CARBON DIOXIDE ABSORPTION. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/839556.

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Marcus Hilliard. THERMODYNAMICS OF AQUEOUS PIPERAZINE/POTASSIUM CARBONATE/CARBON DIOXIDE CHARACTERIZED BY THE ELECTROLYTE NRTL MODEL WITHIN ASPEN PLUS. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/838130.

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Chen, Eric, Steven Fulk, Matt Beaudry, et al. Evaluation of Concentrated Piperazine for CO₂ Capture from Coal-Fired Flue Gas (Final Report, REV0). Office of Scientific and Technical Information (OSTI), 2019. http://dx.doi.org/10.2172/1512446.

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