Relevant bibliographies by topics / Piperazine D

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters

Academic literature on the topic 'Piperazine D'

Author: Grafiati
Published: 5 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Piperazine D"

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Verma, Arvind Kumar, Arun Kumar, and Kunwar Abhishek Singh. "Synthesis and molecular docking for anticonvulsant activity of some new benzoxazole derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 551. https://doi.org/10.59467/ijhc.2025.35.551.

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To explore the anticonvulsant action related to the benzoxazole framework, a series of benzoxazole-piperazine derivatives, namely N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-(piperazin-1-yl) acetamides (3a-e) (3), was synthesized by reacting N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-chloroacetamide (2) with various substituted piperazines. Molecular docking studies were conducted using Auto Dock Vina 1.5.7 to evaluate the compounds' binding affinities with anticonvulsant-related targets protein data bank ID: 3PO7, 7WLJ, using zonisamide as a standard drug to ensure their potential. Several compounds exhibit
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Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were
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Patel, Nalini, Vaishali Karkhanis, and Pinkal Patel. "Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 353–58. http://dx.doi.org/10.22270/jddt.v9i4-s.3327.

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Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent
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Wu, Yuet, Silvia Parapini, Ian Williams, et al. "Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities." Molecules 23, no. 7 (2018): 1713. http://dx.doi.org/10.3390/molecules23071713.

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According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we assessed the effects of attaching sugars to N-4 of the dihydroartemisinin (DHA)-piperazine derivative prepared in one step from DHA and piperazine. N-Glycosylated DHA-piperazine derivatives were obtained according to the Kotchetkov reaction by heating the DHA-piperazine with the sugar in a polar solvent. Structure of the D-glucose derivative is se
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Mamat, Constantin, Marc Pretze, Matthew Gott, and Martin Köckerling. "Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling." Beilstein Journal of Organic Chemistry 12 (November 21, 2016): 2478–89. http://dx.doi.org/10.3762/bjoc.12.242.

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Novel, functionalized piperazine derivatives were successfully synthesized and fully characterized by 1H/13C/19F NMR, MS, elemental analysis and lipophilicity. All piperazine compounds occur as conformers resulting from the partial amide double bond. Furthermore, a second conformational shape was observed for all nitro derivatives due to the limited change of the piperazine chair conformation. Therefore, two coalescence points were determined and their resulting activation energy barriers were calculated using 1H NMR. To support this result, single crystals of 1-(4-nitrobenzoyl)piperazine (3a,
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A., Ocheni, Ukoha P.O., and Hosten E. "Single crystal synthesis and structure of 2-phenyl-1-(4-phenylacetyl-piperazin-1-yl) ethanone and antimalarial potential evaluation." Chemistry International 8, no. 4 (2022): 101–5. https://doi.org/10.5281/zenodo.7196736.

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In the present investigation, 2-phenyl-1-(4-phenylacetyl-piperazin-1-yl) ethanone was prepared and antimalarial activity was also evaluated. The reactions of phenylacetyl chloride and piperazine in trichloromethane at 60 <strong><sup>0</sup></strong>C affording a dione, 2-Phenyl-1-(4-Phenylacetyl-piperazin-1-yl)ethanone (L) furnished a good yield. This compound was characterized by melting point determination, solubility, UV-Vis, FTIR and nuclear magnetic resonance spectroscopy. The crystal structure was confirmed and established by X-ray Crystallography. The afforded dione with molecular weig
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Maini, L., D. Braga, P. P. Mazzeo, et al. "Dual luminescence in solid CuI(piperazine): hypothesis of an emissive 1-D delocalized excited state." Dalton Transactions 44, no. 29 (2015): 13003–6. http://dx.doi.org/10.1039/c5dt02204e.

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Aghabali, Amineh, Sharon Jun, Marilyn M. Olmstead, and Alan L. Balch. "The directional character of the piperazine double addition product, e{N(CH2CH2)2N}2C60, as a building block for forming crystalline fullerene polymers." CrystEngComm 20, no. 7 (2018): 924–29. http://dx.doi.org/10.1039/c7ce02117h.

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The piperazine double addition product, <sup>e</sup>{N(CH<sub>2</sub>CH<sub>2</sub>)<sub>2</sub>N}<sub>2</sub>C<sub>60</sub>, has its donor atoms positioned to bind Lewis acids in two orthogonal directions. It has been used to construct crystalline, 1-d and 2-d polymers through reactions with diiodine and the rhodium(ii) acetate dimer.
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Addison, Anthony W., Stephen J. Jaworski, Jerry P. Jasinski, et al. "Chlorocobalt complexes with pyridylethyl-derived diazacycloalkanes." Acta Crystallographica Section E Crystallographic Communications 78, no. 3 (2022): 235–43. http://dx.doi.org/10.1107/s2056989022001220.

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Syntheses are described for the blue/purple complexes of cobalt(II) chloride with the tetradentate ligands 1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Ppz), 1,4-bis[2-(pyridin-2-yl)ethyl]homopiperazine (Phpz), trans-2,5-dimethyl-1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Pdmpz) and tridentate 4-methyl-1-[2-(pyridin-2-yl)ethyl]homopiperazine (Pmhpz). The CoCl2 complexes with Ppz, namely, {μ-1,4-bis[2-(pyridin-2-yl)ethyl]piperazine}bis[dichloridocobalt(II)], [Co2Cl4(C18H24N4)] or Co2(Ppz)Cl4, and Pdmpz (structure not reported as X-ray quality crystals were not obtained), are shown to be dinuclear,
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Xu, Shan, Cheng Yu Sun, Fei Lei, et al. "Synthesis of 4-(2-(Piperazin-1-Yl)-7,8-Dihydro-5H-Thiopyrano[4,3-d]Pyrimidin-4-yl)Morpholine and 4-Morpholino-2-(Piperazin-1-Yl)- 7,8-Dihydro-5H-Thiopyrano[4,3-d]Pyrimidine 6,6-Dioxide." Applied Mechanics and Materials 651-653 (September 2014): 111–14. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.111.

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Two novel thiopyrano [4,3-d] pyrimidine derivatives 7 and 8 were synthesized from dimethyl 3,3'-thiodipropanoate through six steps including two times of cyclization, chlorination, oxidation, substitution with morpholine and piperazine and their structures were confirmed by1H NMR and MS spectrum. The total yield of the six steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropanoate). The synthetic routes of them can be used to synthesize PI3K/mTOR inhibitors bearing a thiopyrano [4,3-d] pyrimidine nucleus.
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Dissertations / Theses on the topic "Piperazine D"

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Descamps, Florian. "Conception, synthèse et évaluation de composés anti-Alzheimer et de sondes chimiques pour l’élucidation de leur mode d’action." Thesis, Lille, 2019. http://www.theses.fr/2019LILUS056.

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La maladie d’Alzheimer est la forme la plus fréquente de démence, caractérisée par l’agrégation et l’accumulation intraneuronale de protéines Tau associées aux microtubules anormalement modifiées (pathologie Tau) ainsi que par des dépôts amyloïdes extra-neuronaux (pathologie amyloïde). Il n'existe actuellement aucun traitement curatif pour la maladie d’Alzheimer. Les traitements disponibles n'offrent que des avantages symptomatiques modestes et à court terme et ne sont de fait plus remboursés par la Sécurité Sociale.Une famille de molécules (MSBD) développée dans notre laboratoire a montré des
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Hannachi, Jean-Christophe. "Synthese d'hydrazinoacides l ou d diproteges orthogonalement. Application a la synthese de derives de l'acide piperazique et de perhydrazinopeptides." Lyon, École normale supérieure (sciences), 1999. http://www.theses.fr/1999ENSL0127.

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Ce travail a pour objet l'etude de la synthese de derives d'hydrazinoacides enantiopurs. La premiere etape a consiste a obtenir les derives hydrazines des principaux aminoacides proteogeniques. Pour cela, nous avons mis en uvre une voie originale passant par l'amination de n-benzylaminoacides a l'aide d'un reactif d'amination electrophile, une oxaziridine. Cette methode nous a permis d'obtenir rapidement et avec de bons rendements des hydrazinoacides enantiopurs diversement substitues sur la chaine laterale et diproteges orthogonalement sur la fonction hydrazine. Disposant de tels synthons, de
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Adongo, John [Verfasser], Klaus [Gutachter] Rademann, Hinrichs [Gutachter] Karsten, and Nicola [Gutachter] Pinna. "Modification of Surfaces with Carboxymethylthio and Piperazinyl Chelating Ligands for Heavy Metal Trapping Applications / John Adongo ; Gutachter: Klaus Rademann, Hinrichs Karsten, Nicola Pinna." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1182540945/34.

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Ermatchkov, Viktor [Verfasser]. "Phasengleichgewichte in komplexen, chemisch reagierenden Systemen : NH3 + SO2 + H2O + Salze und CO2 + H2O + MDEA, Piperazin / vorgelegt von Viktor Ermatchkov." 2006. http://d-nb.info/980777488/34.

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Wierschem, Frank Georg [Verfasser]. "Darstellung und Modifizierung von 2-Oxo-piperazin-basierenden Isoxazolinen und Isoxazolidinen in Lösung und an fester Phase / vorgelegt von Frank Georg Wierschem." 2004. http://d-nb.info/971626812/34.

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Guitot, Karine [Verfasser]. "Synthesis and conformational analysis of peptidomimetics containing unnatural amino acids based on a piperazinone and γ-butyrolactone [gamma-butyrolactone] scaffolds / vorgelegt von Karine Guitot". 2008. http://d-nb.info/1004102666/34.

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Saeed, Muhammad [Verfasser]. "Total syntheses of R-(-)-argentilactone, S-(+)-argentilactone, R-(-)-massoilactone, (5S,6R)-O-acetylosmundalactone as-triazin-, trithiocarbonate- and 4-(4-substituted-1-piperazinyl) derivatives from sugar templates = Totalsynthesen von R-(-)-Argentilacton, S-(+)-Argentilacton, R-(-)-Massoilacton, (5S,6R)-O-Acetylosmundalacton as-Triazin-, Trithiocarbonat- und 4-(4-substituierten 1-Piperazinyl)-Derivaten aus Zucker-Templaten / vorgelegt von Muhammad Saeed." 2001. http://d-nb.info/963217488/34.

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Book chapters on the topic "Piperazine D"

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da Silva, Francisco Ordelei Nascimento, Daniel de Lima Pontes, Ana Cristina Facundo de Brito Pontes, and Katherine Lima Bruno. "ESTUDO ESPECTROSCÓPICO E ELETROQUÍMICO DE NOVOS COMPLEXOS MONO E BINUCLEARES DE CU(II) E FE(II) COM LIGANTES NITROGENADOS." In Open Science Research XIII. Editora Científica Digital, 2023. http://dx.doi.org/10.37885/230914337.

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Objetivo: Sintetizar o complexo heterobinuclear de cobre (II) e ferro (II), a partir dos seus precursores – [Cu(phen)(pip)NO2]Cl e Na2[Fe(CN)4(NH3)2], em que a piperazina (pip) apresenta-se como o ligante em ponte entre os dois centros metálicos Métodos: Os complexos mononucleares e binuclear de cobre e ferro foram caracterizados por técnicas espectroscópicas (Espectroscopia vibracional na região do infravermelho, espectroscopia eletrônica na região do Uv-Vis) e eletroquímica (voltametria cíclica) Resultados: Por meio do IV e Uv-vis, foi possível verificar os principais modos vibracionais da f
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