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Journal articles on the topic 'Piperazine D'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Verma, Arvind Kumar, Arun Kumar, and Kunwar Abhishek Singh. "Synthesis and molecular docking for anticonvulsant activity of some new benzoxazole derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 551. https://doi.org/10.59467/ijhc.2025.35.551.

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To explore the anticonvulsant action related to the benzoxazole framework, a series of benzoxazole-piperazine derivatives, namely N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-(piperazin-1-yl) acetamides (3a-e) (3), was synthesized by reacting N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-chloroacetamide (2) with various substituted piperazines. Molecular docking studies were conducted using Auto Dock Vina 1.5.7 to evaluate the compounds' binding affinities with anticonvulsant-related targets protein data bank ID: 3PO7, 7WLJ, using zonisamide as a standard drug to ensure their potential. Several compounds exhibit

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2

Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were

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3

Patel, Nalini, Vaishali Karkhanis, and Pinkal Patel. "Synthesis and Biological Evaluation of Some Piperazine Derivatives as Anti-Inflammatory Agents." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 353–58. http://dx.doi.org/10.22270/jddt.v9i4-s.3327.

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Some 1-((4-methylpiperazin-1yl)methyl)-1H-benzo[d]imidazole & 1-((4-phenylpiperazin-1yl)methyl)-1H-benzo[d]imidazole derivatives were synthesized through reaction of 1-substituted piperazines with different benzimidazole derivatives in methanol yielded the corresponding mannich bases (42-a to 42-i). All the synthesized compounds were elucidated by IR, 1H NMR and MASS spectroscopy. They were tested for anti-inflammatory activity using in-vivo (Carrageenan- induced rat paw edema model) method at a dose of 50mg/kg. result showed that compounds 42-c, 42-d and 42-h were found to be most potent

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Wu, Yuet, Silvia Parapini, Ian Williams, et al. "Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities." Molecules 23, no. 7 (2018): 1713. http://dx.doi.org/10.3390/molecules23071713.

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According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we assessed the effects of attaching sugars to N-4 of the dihydroartemisinin (DHA)-piperazine derivative prepared in one step from DHA and piperazine. N-Glycosylated DHA-piperazine derivatives were obtained according to the Kotchetkov reaction by heating the DHA-piperazine with the sugar in a polar solvent. Structure of the D-glucose derivative is se

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5

Mamat, Constantin, Marc Pretze, Matthew Gott, and Martin Köckerling. "Synthesis, dynamic NMR characterization and XRD studies of novel N,N’-substituted piperazines for bioorthogonal labeling." Beilstein Journal of Organic Chemistry 12 (November 21, 2016): 2478–89. http://dx.doi.org/10.3762/bjoc.12.242.

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Novel, functionalized piperazine derivatives were successfully synthesized and fully characterized by 1H/13C/19F NMR, MS, elemental analysis and lipophilicity. All piperazine compounds occur as conformers resulting from the partial amide double bond. Furthermore, a second conformational shape was observed for all nitro derivatives due to the limited change of the piperazine chair conformation. Therefore, two coalescence points were determined and their resulting activation energy barriers were calculated using 1H NMR. To support this result, single crystals of 1-(4-nitrobenzoyl)piperazine (3a,

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6

A., Ocheni, Ukoha P.O., and Hosten E. "Single crystal synthesis and structure of 2-phenyl-1-(4-phenylacetyl-piperazin-1-yl) ethanone and antimalarial potential evaluation." Chemistry International 8, no. 4 (2022): 101–5. https://doi.org/10.5281/zenodo.7196736.

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In the present investigation, 2-phenyl-1-(4-phenylacetyl-piperazin-1-yl) ethanone was prepared and antimalarial activity was also evaluated. The reactions of phenylacetyl chloride and piperazine in trichloromethane at 60 <strong><sup>0</sup></strong>C affording a dione, 2-Phenyl-1-(4-Phenylacetyl-piperazin-1-yl)ethanone (L) furnished a good yield. This compound was characterized by melting point determination, solubility, UV-Vis, FTIR and nuclear magnetic resonance spectroscopy. The crystal structure was confirmed and established by X-ray Crystallography. The afforded dione with molecular weig

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7

Maini, L., D. Braga, P. P. Mazzeo, et al. "Dual luminescence in solid CuI(piperazine): hypothesis of an emissive 1-D delocalized excited state." Dalton Transactions 44, no. 29 (2015): 13003–6. http://dx.doi.org/10.1039/c5dt02204e.

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8

Aghabali, Amineh, Sharon Jun, Marilyn M. Olmstead, and Alan L. Balch. "The directional character of the piperazine double addition product, e{N(CH2CH2)2N}2C60, as a building block for forming crystalline fullerene polymers." CrystEngComm 20, no. 7 (2018): 924–29. http://dx.doi.org/10.1039/c7ce02117h.

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The piperazine double addition product, <sup>e</sup>{N(CH<sub>2</sub>CH<sub>2</sub>)<sub>2</sub>N}<sub>2</sub>C<sub>60</sub>, has its donor atoms positioned to bind Lewis acids in two orthogonal directions. It has been used to construct crystalline, 1-d and 2-d polymers through reactions with diiodine and the rhodium(ii) acetate dimer.

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9

Addison, Anthony W., Stephen J. Jaworski, Jerry P. Jasinski, et al. "Chlorocobalt complexes with pyridylethyl-derived diazacycloalkanes." Acta Crystallographica Section E Crystallographic Communications 78, no. 3 (2022): 235–43. http://dx.doi.org/10.1107/s2056989022001220.

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Syntheses are described for the blue/purple complexes of cobalt(II) chloride with the tetradentate ligands 1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Ppz), 1,4-bis[2-(pyridin-2-yl)ethyl]homopiperazine (Phpz), trans-2,5-dimethyl-1,4-bis[2-(pyridin-2-yl)ethyl]piperazine (Pdmpz) and tridentate 4-methyl-1-[2-(pyridin-2-yl)ethyl]homopiperazine (Pmhpz). The CoCl2 complexes with Ppz, namely, {μ-1,4-bis[2-(pyridin-2-yl)ethyl]piperazine}bis[dichloridocobalt(II)], [Co2Cl4(C18H24N4)] or Co2(Ppz)Cl4, and Pdmpz (structure not reported as X-ray quality crystals were not obtained), are shown to be dinuclear,

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10

Xu, Shan, Cheng Yu Sun, Fei Lei, et al. "Synthesis of 4-(2-(Piperazin-1-Yl)-7,8-Dihydro-5H-Thiopyrano[4,3-d]Pyrimidin-4-yl)Morpholine and 4-Morpholino-2-(Piperazin-1-Yl)- 7,8-Dihydro-5H-Thiopyrano[4,3-d]Pyrimidine 6,6-Dioxide." Applied Mechanics and Materials 651-653 (September 2014): 111–14. http://dx.doi.org/10.4028/www.scientific.net/amm.651-653.111.

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Two novel thiopyrano [4,3-d] pyrimidine derivatives 7 and 8 were synthesized from dimethyl 3,3'-thiodipropanoate through six steps including two times of cyclization, chlorination, oxidation, substitution with morpholine and piperazine and their structures were confirmed by1H NMR and MS spectrum. The total yield of the six steps was 18.6% (calculated from methyl dimethyl 3,3'-thiodipropanoate). The synthetic routes of them can be used to synthesize PI3K/mTOR inhibitors bearing a thiopyrano [4,3-d] pyrimidine nucleus.

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11

Sullivan, Dexter W., Shayne C. Gad, Bryan Laulicht, Sasha Bakhru, and Solomon Steiner. "Nonclinical Safety Assessment of PER977." International Journal of Toxicology 34, no. 4 (2015): 308–17. http://dx.doi.org/10.1177/1091581815590667.

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A new molecular entity, PER977 (di-arginine piperazine), is in clinical development as an anticoagulant reversal agent for new oral anticoagulants and heparins. The good laboratory practices (GLP)-compliant studies were conducted to evaluate the toxicity of PER977 and its primary metabolite, 1,4-bis(3-aminopropyl)piperazine (BAP). PER977 and BAP were negative for systemic toxicity in dogs and rats. PER977 was rapidly eliminated from the blood with little to no accumulation. PER977 was negative for genotoxicity and did not alter neurological, respiratory, or cardiovascular function. Maximum tol

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12

Chen, Chen, Cheng Yu Sun, Shan Xu, Yuan Biao Tu, Peng Wu Zheng, and Wu Fu Zhu. "Synthesis of One Novel Thieno[2,3-D]Pyrimidine Derivative Bearing a Sulfonylurea Moiety." Advanced Materials Research 1015 (August 2014): 577–80. http://dx.doi.org/10.4028/www.scientific.net/amr.1015.577.

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A novel thieno [2,3-d] pyrimidine compound (1) bearing a sulfonylurea moiety was synthesized from methyl 2-aminothiophene-3-carboxylate (2) through five steps including cyclization, chlorination, substitution with morpholine and piperazine, amidation and its structure was confirmed by 1H NMR and MS spectrum. The total yield of the five steps was 16.2% ( calculated from methyl 2-aminothiophene-3-carboxylate).

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13

Hammouda, M., W. S. Hamama, and E. M. Afsah. "A Study on the Mannich Reaction with 1-Phenylamino-3-indenone." Zeitschrift für Naturforschung B 42, no. 1 (1987): 94–96. http://dx.doi.org/10.1515/znb-1987-0118.

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Abstract Mannich reaction of the title compound 1 with formaldehyde and morpholine, piperidine or piperazine afforded the Mannich bases 3-5 respectively, whereas the indeno[1.2-d]pyrimidines (6-7) were obtained where primary amines were used. Treatment of 2 with formaldehyde gave benz[b]indeno-diazepine (8). The reaction of formaldehyde with 1 was also investigated.

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14

Kanesaka, Isao, Kazuhiko Kuwano, and Tsutomu Ishioka. "Raman spectra of piperazine hexahydrate and N-D stretches by polarons." Journal of Raman Spectroscopy 24, no. 12 (1993): 889–95. http://dx.doi.org/10.1002/jrs.1250241211.

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15

Islam, SA, MM Rahman, MA Hossain, MGA Chowdhury, and M. Mostafa. "COMPARATIVE EFFICACY OF SOME MODERN ANTHELMINTICS AND PINEAPPLE LEAVES WITH THEIR EFFECTS ON CERTAIN BLOOD PARAMETERS AND BODY WEIGHT GAIN IN CALVES." Bangladesh Journal of Veterinary Medicine 3, no. 1 (2012): 33–37. http://dx.doi.org/10.3329/bjvm.v3i1.11340.

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A twenty five calves of naturally infected with ascarid parasites were treated with different modern anthelmintics and pineapple leaves to study the comparative efficacy during the period from January to September 1997. The calves were divided into five groups. Groups A, B, C, D were treated with ivermectin (200 ?g / kg SC), albendazole (7.5 mg / kg orally), piperazine citrate (200 mg / kg orally) and pineapple leaves extract (1g / kg orally) respectively and group E was kept as untreated control. On the basis of faecal egg count of ascaris in calves, ivermectin was found to be more effective

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16

Chang, Ding-Kwo, Shu-Fang Cheng, and Ting-Lin Chien. "Molecular mechanics calculations on the complexes between analogues of Hoechst 33258 and d(CGCGAAT-TCGCG)2: influence of bulky group substitution on base pair preference of DNA minor groove binders." Canadian Journal of Chemistry 73, no. 6 (1995): 878–84. http://dx.doi.org/10.1139/v95-110.

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Molecular mechanics calculations were performed on the three structures of the complexes formed by the derivatives of Hoechst 33258 and dodecameric DNA duplex d(CGCGAATTCGCG)2. Formation and docking energies of these complexes were compared. It was found that the CG site that is 3′ to the central AATT region can be tolerated by the drugs. This is probably due to the presence of the bulky piperazine ring and, more pronouncedly, by alkylated analogues of the drug that prefer the wider minor groove formed by the GC base pair region of B-DNA. The argument of bulkiness of the piperazine moiety as t

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17

Odoma, Saidi, Felix Twinomugisha, Timothy Neeza, and Funso Funso-Babarimisa. "Evaluation of the anthelmintic activity of ethanol leaf extract of <i>Dimocarpus longan</i> (Lour.) against <i>Taenia solium</i>." Journal of Pharmacy & Bioresources 22, no. 1 (2025): 45–52. https://doi.org/10.4314/jpb.v22i1.5.

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Helminth infections affects nearly 1.5 billion people worldwide, particularly in tropical and subtropical regions, where poverty, inadequate housing, and poor sanitation, exacerbate their impact. These infections pose significant health and economic burdens, and the limited effectiveness of current anthelmintic drugs underscores the need for alternative treatments. Dimocarpus longan, traditionally used in various forms of medicine, is rich in bioactive compounds such as flavonoids, tannins, and saponins, which are known to exhibit antiparasitic properties. This study evaluated the anthelmintic

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18

Abu-Hashem, Ameen Ali, Sami A. Al-Hussain, and Magdi E. A. Zaki. "Synthesis of Novel Benzodifuranyl; 1,3,5-Triazines; 1,3,5-Oxadiazepines; and Thiazolopyrimidines Derived from Visnaginone and Khellinone as Anti-Inflammatory and Analgesic Agents." Molecules 25, no. 1 (2020): 220. http://dx.doi.org/10.3390/molecules25010220.

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Novel (4-methoxy or 4,8-dimethoxy)-3-methyl-N-(6-oxo-2-thioxo-1,2,3, 6-tetrahydro- pyrimidin-4-yl) benzo [1,2-b: 5, 4-b’] difuran-2-carboxamide (5a–b) has been synthesized by the reaction of visnagenone–ethylacetate (2a) or khellinone–ethylacetate (2b) with 6-aminothiouracil in dimethylformamide or refluxing of benzofuran-oxy-N-(2-thioxopyrimidine) acetamide (4a–b) in sodium ethoxide to give the same products (5a,b) in good yields. Thus, compounds 5a–b are used as an initiative to prepare many new heterocyclic compounds such as 2-(4-(3-methylbenzodifuran- 2-carbox-amido) pyrimidine) acetic aci

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19

Isabirye, Robert Alex, Savino Biryomumaisho, James Okwee-Acai, Samuel Okello, and George William Nasinyama. "Effect of Diatomaceous Earth on Growth Rate, Egg Production, Feed Conversion Efficiency and Parasitic Load in Hens Raised on Deep Litter." European Journal of Agriculture and Food Sciences 3, no. 1 (2021): 97–103. http://dx.doi.org/10.24018/ejfood.2021.3.1.207.

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The efficacy of diatomaceous earth (DE) on growth rate, egg production and on increasing feed conversion efficiency in deep litter raised layer hens was evaluated. The study was conducted at Mukono Zonal Agricultural Research and Development Institute (MUZARDI) in Uganda. Worms were collected from fresh intestines of indigenous chicken obtained from Kalerwe chicken market near Kampala. The DE was mined in Pakwach (formerly Nebbi) district in Northern Uganda. Chickens of the Lohmann Brown breed raised on deep litter were studied. At 7 weeks the birds were divided into 5 treatment groups, A, B,

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20

Kondoh, Osamu, Yukiko Inagaki, Hiroshi Fukuda та ін. "Piperazine Propanol Derivative as a Novel Antifungal Targeting 1,3-β-D-Glucan Synthase". Biological & Pharmaceutical Bulletin 28, № 11 (2005): 2138–41. http://dx.doi.org/10.1248/bpb.28.2138.

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21

Göktaş, Bünyamin, Harun Uslu, Derya Osmaniye, et al. "Synthesis of some benzothiazole-piperazine derivatives, investigation by in vitro and molecular modelling for hMAO inhibitory activities." European Journal of Life Sciences 3, no. 2 (2024): 72–81. http://dx.doi.org/10.55971/ejls.1497558.

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Monoamine oxidase (MAO) is an enzyme that helps regulate the functions of intracellular amines, as well as chemicals such as dopamine, serotonin and norepinephrine, in the brain and its tissues. Active substances that are inhibitors of monoamine oxidases (MAOs) are used in the treatment of anxiety, depression and Alzheimer’s disease. Previous studies have shown that compounds containing piperazine rings show MAO-A inhibitory activity. Based on these studies, 4 compounds containing piperazine and benzothiazole rings were designed, and the structures of the compounds were elucidated using spectr

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22

Bhattacharjee, Chiranjib, Santhosh Kumar Chinnaiyan, and Neelutpal Gogoi. "Anthelmintic activity of leaves extracts of Olea europaea on Pheretima posthuma." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 1 (2018): 33–35. http://dx.doi.org/10.33974/ijrpst.v1i1.34.

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Parasitic roundworms (nematodes) cause substantial morbidity and mortality in livestock animals globally and considerable productivity losses to farmers. The control of these nematodes has relied largely on the use of a limited number of anthelmintics. However, resistance to many of these anthelmintics is now widespread, and, therefore, there is a need to find new drugs to ensure sustained and effective treatment and control into the future. The present study was undertaken to evaluate the anthelmintic activity of crude aqueous, Petroleum ether, chloroform and methanol extract Olea europaea le

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23

Bullock, Ross, David I. Graham, Min-Hsiung Chen, David Lowe, and James McCulloch. "Focal Cerebral Ischemia in the Cat: Pretreatment with a Competitive NMDA Receptor Antagonist, D-CPP-ene." Journal of Cerebral Blood Flow & Metabolism 10, no. 5 (1990): 668–74. http://dx.doi.org/10.1038/jcbfm.1990.120.

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The effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist D-( E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPP-ene; SDZ EAA 494) upon ischemic brain damage have been examined in anesthetized cats. Focal cerebral ischemia was produced by permanent occlusion of the middle cerebral artery (MCA) and the animals were killed 6 h later. The amount of early ischemic brain damage was assessed in coronal sections at 16 predetermined stereotaxic planes. Pretreatment with D-CPP-ene (15 mg/kg i.v. followed by continuous infusion at 0.17 mg/kg/min until death), 15 min pr

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Munirathinam, Rajesh, Jurriaan Huskens, and Willem Verboom. "Piperazine-Containing Polymer Brush Layer as Supported Base Catalyst in a Glass Microreactor." Journal of Flow Chemistry 4, no. 3 (2014): 135–39. http://dx.doi.org/10.1556/jfc-d-14-00020.

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25

Patel, Smita, Astrid G. Chapman, Joanne L. Graham, Brian S. Meldrum, and Peter Frey. "Anticonvulsant activity of the NMDA antagonists, d(−)4-(3-phosphonopropyl)piperazine-2-carboxylic acid (D-CPP) and d(−)(E)-4-(3-phosphonoprop-2-enyl) piperazine-2-carboxylic acid (D-CPPene) in a rodent and a primate model of reflex epilepsy." Epilepsy Research 7, no. 1 (1990): 3–10. http://dx.doi.org/10.1016/0920-1211(90)90049-2.

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Swapna, P. V. Devi, and G. Saravanan. "A comprehensive analysis of analytical techniques for the quantification of ivabradine and trimetazidine." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 529. https://doi.org/10.59467/ijhc.2024.34.529.

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Ivabradine, chemically (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino) propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride is mainly used in treating patients with heart failure having the heartbeat of above 70 bpm. It diminishes the heartbeat by blocking the If. Trimetazidine (TMZ) is piperazine derivative. It is chemically 1-(2,3,4-trimethoxy benzyl), piperazine. It has cytoprotective properties that normalize metabolic disturbances in low-flow ischemia, but the drug is mainly known for its anti-anginal activity. This review prese

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27

Karim, El Mehdi, Oussama Abchir, Hassan Nour, et al. "In Silico Design of Novel Piperazine-Based mTORC1 Inhibitors Through DFT, QSAR and ADME Investigations." Biophysica 4, no. 4 (2024): 517–29. http://dx.doi.org/10.3390/biophysica4040034.

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Mammalian target of rapamycin complex 1 (mTORC1) is an important and promising alternative biological target for the treatment of different types of cancer including breast, lung and renal cell carcinoma. This study contributed to the development of mathematical models highlighting the quantitative structure-activity relationship of a series of piperazine derivatives reported as mTORC1 inhibitors. Various molecular descriptors were calculated using Gaussian 09, Chemsketch, and ChemOffice software. The density funcional theory (DFT) method at the level B3LYP/6-31G+(d, p) was applied to determin

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Ding, Xue-Hua, Yong-Hua Li, Shi Wang, and Wei Huang. "Proton-transfer supramolecular salts of d-/l-tartaric acid and 1-(2-Pyrimidyl)piperazine." Journal of Molecular Structure 1062 (March 2014): 61–67. http://dx.doi.org/10.1016/j.molstruc.2013.12.054.

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29

Faghih, R., K. Phelan, T. A. Esbenshade, et al. "D-alanine piperazine-amides: novel non-imidazole antagonists of the histamine H 3 receptor." Inflammation Research 52 (April 1, 2003): s47—s48. http://dx.doi.org/10.1007/s000110300049.

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Kshatriya, Monika R., and Jinal A. Gajjar. "Design and synthesis of novel benzotriazole-based hybrids with enhanced antimicrobial, antimalarial, and antitubercular potentials." Current Chemistry Letters 14, no. 2 (2025): 289–98. https://doi.org/10.5267/j.ccl.2024.11.005.

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We have synthesized all drugs using previously identified active pharmacophores through molecular hybridization. This paper explains a simple method for making N-((2-(piperazine-1-yl)-2,3-dihydro-1H-benzo[d][1,2,3]triazol-1-yl)methyl)aniline analogs 5(A–L) through steps. We used mass spectrometry, 1H NMR, and 13C NMR to do a spectrum analysis to confirm the structure of the synthesized end products. We evaluated all synthesized compounds for their in vitro antimicrobial, antimalarial, and antitubercular activities. We have also examined the research on structure-activity relationships (SAR). T

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Chen, Pao-Chi, Jyun-Hong Jhuang, and Zhong-Yi Lin. "Piperazine-Based Mixed Solvents for CO2 Capture in Bubble-Column Scrubbers and Regeneration Heat." Processes 12, no. 10 (2024): 2178. http://dx.doi.org/10.3390/pr12102178.

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This work used piperazine (PZ) as a base solvent, blended individually with five amines, which were monoethanolamine (MEA), secondary amines (DIPAs), tertiary amines (TEAs), stereo amines (AMPs), and diethylenetriamine (DETA), to prepare mixed solvents at the desired concentrations as the test solvents. A continuous bubble-column scrubber with one stage (1 s) was first used for the test. Six parameters were selected, including the type of mixed solvent (A), the ratio of mixed solvents (B), the solvent feed rate (C), the gas flow rate (D), the concentration of the mixed solvents (E), and the li

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Abbaz, Tahar, Amel Bendjeddou, and Didier Villemin. "Structural and quantum chemical studies on aryl sulfonyl piperazine derivatives." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 88–97. http://dx.doi.org/10.22270/jddt.v9i1-s.2264.

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The optimized molecular structure and electronic features of aryl sulfonyl piperazine derivatives 1-4 have been investigated theoretically using Gaussian 09 software package and DFT/B3LYP method with 6-31G (d,p) basis set. The reactivity of the title molecules was investigated and both the positive and negative centers of the molecules were identiﬁed using molecular electrostatic potential (MEP) analysis which the results illustrate that the regions reveal the negative electrostatic potential are localized in sulfamide function while the regions presenting the positive potential are localized

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Xu, Xiuli, Jiahui Han, Rui Lin, Steven Polyak, and Fuhang Song. "Two New Piperazine-Triones from a Marine-Derived Streptomycetes sp. Strain SMS636." Marine Drugs 17, no. 3 (2019): 186. http://dx.doi.org/10.3390/md17030186.

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Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were confirmed by comprehensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR. Compound 4 exhibited moderate antibacterial activities against Staphylococcus aureus and methicillin resistant S. aureus (MRSA) with Minimum Inhibitory Concentration (MIC) values of 12.5 and 25 μ

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Juan, S. Gómez-Jeria, and Pinto-Saldaña Matías. "Electronic structure and D2, 5-HT1A, 5-HT2A and H3 receptor affinities of some multi-target heterocycle piperazine derivatives. A DFT and FQSAR study." Chemistry Research Journal 7, no. 6 (2022): 52–83. https://doi.org/10.5281/zenodo.11533022.

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<strong>Abstract </strong>The Klopman-Peradejordi-Gómez (KPG) QSAR method has been employed to find significant relationships between the electronic structure of a group of multi-target heterocycle piperazine derivatives and the D<sub>2</sub>, 5-HT<sub>1A</sub>, 5-HT<sub>2A</sub> and H<sub>3</sub> receptor affinities. The electronic structure of all molecules was calculated at the B3LYP/6-311g(d,p) level using water as solvent. For each receptor affinity, statistically significant equations were obtained relating the variation of receptor affinity with the variation of the numerical val

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Gordon, Irit, Ronit Weizman, and Moshe Rehavi. "[3H]GBR 12935 labels mainly the piperazine acceptor site in the rat prefrontal cortex." Brain Research 674, no. 2 (1995): 205–10. http://dx.doi.org/10.1016/0006-8993(95)00007-d.

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OSA, Yumiko, Yoko SATO, Akiko HATANO, and Hiroaki TAKAYANAGI. "Crystal Structure of N-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptan-5-yl)-piperazine Hydrochloride." Analytical Sciences 18, no. 9 (2002): 1069–70. http://dx.doi.org/10.2116/analsci.18.1069.

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Caputo, O., F. Rocco, and G. Grosa. "Metabolism of 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120) by rat liver microsomes." European Journal of Drug Metabolism and Pharmacokinetics 19, no. 4 (1994): 303–10. http://dx.doi.org/10.1007/bf03188856.

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Yu, Jie-Hui, Jing Lu, Xiao Zhang, Ling Ye, Qin Hou, and Ji-Qing Xu. "Structure characterization of a novel 3-D cadmium-halo coordination polymer linked by piperazine bridge." Inorganic Chemistry Communications 9, no. 4 (2006): 415–17. http://dx.doi.org/10.1016/j.inoche.2006.02.004.

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Mareedu, Rajendra Swami, and Pandeeswaran M. "Design and Synthesis of Novel 2, 5-Substituted Pyrido[4,3-d]Pyrimidines: In silico, Anti-diabetic and Anti-inflammatory Studies." Oriental Journal Of Chemistry 40, no. 6 (2025): 1634–46. https://doi.org/10.13005/ojc/400614.

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Recently, there has been a growing interest in small drug molecules due to their ability to be easily customized with specific active sites of biomolecules. Sulfonyl-based compounds, in particular, have shown promise for various pharmacological applications and many of these drug molecules are now available in the commercial market. As a result, there is a significant increase in demand for small molecule compounds and their studies in pharmacological applications. In this context, we have presented a range of pyridopyrimidine derivatives functionalized with piperazine sulfonamides and various

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Olszewska, E., B. Tarasiuk, and S. Pikus. "New powder diffraction data of some N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide-potential pesticides." Powder Diffraction 26, no. 4 (2011): 337–45. http://dx.doi.org/10.1154/1.3652921.

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N-derivatives of 4-chloro-3,5-dimethylphenoxyacetamide—2-(4-chloro-3,5-dimethylphenoxy)-N-(4-fluorophenyl)acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(3-chloro-4-fluorophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[4-chloro-3-(trifluoromethyl)phenyl] acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-[3-chloro-4-methylphenyl]acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-(2,4,6-tribromophenyl) acetamide, 2-(4-chloro-3,5-dimethylphenoxy)-N-pyridin-2-ylacetamide, 1-[(4-chloro-3,5-dimethylphenoxy)acetyl]-4-methylpiperazine, and 1-benzyl-4-[(4-chloro-3,5-dimethylphenoxy)acetyl]piperazine—have

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Afsah, Elsayed M., Saad S. Elmorsy, Soha M. Abdelmageed, and Zaki E. Zaki. "Synthesis of some new hydrazide-hydrazones related to isatin and its Mannich and Schiff bases." Zeitschrift für Naturforschung B 71, no. 11 (2016): 1147–57. http://dx.doi.org/10.1515/znb-2016-0130.

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AbstractThe hydrazide-hydrazones 6a–d and 7a, b were obtained by treating isatin (1) or its Mannich base 2 with hydrazides incorporating piperidine, morpholine, and piperazine units. The reaction of 1 and 2 with hydrazides related to triazenes having piperidine, morpholine, and 1,2,3,4-tetrahydroisoquinoline moieties gave 12a–c and 13a–c. Treatment of 1 and 2 with iminodiacetohydrazide (14) and ethylenediamine tetraacetohydrazide (18) afforded 15–17 and 19a, b, respectively. The Mannich reaction of the Schiff base 20 with formaldehyde and the appropriate hydrazide or bis(hydrazide) gave 21a, b

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Varano, Flavia, Daniela Catarzi, Erica Vigiani, et al. "Piperazine- and Piperidine-Containing Thiazolo[5,4-d]pyrimidine Derivatives as New Potent and Selective Adenosine A2A Receptor Inverse Agonists." Pharmaceuticals 13, no. 8 (2020): 161. http://dx.doi.org/10.3390/ph13080161.

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The therapeutic use of A2A adenosine receptor (AR) antagonists for the treatment of neurodegenerative disorders, such as Parkinson and Alzheimer diseases, is a very promising approach. Moreover, the potential therapeutic role of A2A AR antagonists to avoid both immunoescaping of tumor cells and tumor development is well documented. Herein, we report on the synthesis and biological evaluation of a new set of piperazine- and piperidine- containing 7-amino-2-(furan-2-yl)thiazolo[5,4-d]pyrimidine derivatives designed as human A2A AR antagonists/inverse agonists. Binding and potency data indicated

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Jyothi, G., Rambabu Palabindela, and Sirassu Narsimha. "Synthesis, Anti-Breast Cancer, and EGFR Activity of Novel Pyrido[2,3-d]pyrimidine-piperazine-1,2,4-oxadiazoles." Russian Journal of General Chemistry 94, no. 6 (2024): 1464–74. http://dx.doi.org/10.1134/s1070363224060239.

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van der Stelt, C., A. Haasjes, H. M. Tersteege, and W. Th Nauta. "Experiments in the 5H-dibenzo[a,d]cycloheptene series II. Synthesis of some esters and piperazine derivatives of 5H-dibenzo[a,d]cycloheptene." Recueil des Travaux Chimiques des Pays-Bas 84, no. 11 (2010): 1466–77. http://dx.doi.org/10.1002/recl.19650841111.

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Shaheen, Farzana, Muhammad Sirajuddin, Saqib Ali, et al. "Organotin(IV) 4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazine-1-carbodithioates: Synthesis, characterization and biological activities." Journal of Organometallic Chemistry 856 (February 2018): 13–22. http://dx.doi.org/10.1016/j.jorganchem.2017.12.010.

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Siddig, Lamia A., Mohammad A. Khasawneh, Abdelouahid Samadi, Haythem Saadeh, Nael Abutaha, and Mohammad Ahmed Wadaan. "Synthesis of novel thiourea-/urea-benzimidazole derivatives as anticancer agents." Open Chemistry 19, no. 1 (2021): 1062–73. http://dx.doi.org/10.1515/chem-2021-0093.

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Abstract A new series of urea and thiourea derivatives containing benzimidazole group as potential anticancer agents have been designed and synthesized. The structures of the synthesized compounds were characterized and confirmed by spectroscopic techniques such as 1H NMR, 13C NMR, and mass spectrometry. In vitro anticancer assay against two breast cancer (BC) cell lines, MDA-MB-231ER(−)/PR(−) and MCF-7ER(+)/PR(+), revealed that the cytotoxicity of 1-(2-(1H-benzo[d]imidazol-2-ylamino)ethyl)-3-p-tolylthiourea (7b) and 4-(1H-benzo[d]imidazol-2-yl)-N-(3-chlorophenyl)piperazine-1-carboxamide (5d)

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Guard, Douglas B., Timothy D. Swartz, Robert C. Ritter, Gilbert A. Burns, and Mihai Covasa. "Blockade of hindbrain NMDA receptors containing NR2 subunits increases sucrose intake." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 296, no. 4 (2009): R921—R928. http://dx.doi.org/10.1152/ajpregu.90456.2008.

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We have previously shown that blockade of N-methyl-d-aspartate (NMDA) receptors in the caudal brain stem delays satiation and increases food intake. NMDA receptors are heterodimers made up of distinct, but different, ion channel subunits. The NR2 subunits of the NMDA receptor contain the binding site for glutamate. About half of vagal afferents express immunoreactivity for NMDA NR2B subunit and about half of the NR2B expressing afferents also express NMDA NR2C or NR2D subunits. This suggests that increased food intake may be evoked by interference with glutamate binding to NMDA channels contai

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Rajendra, Swami Mareedu, M.* Pandeeswaran, Nayak K. Prashanth, et al. "EVALUATION OF NOVEL PYRIDO[4,3-D]PYRIMIDINES ATTACHED WITH PIPERAZINE DERIVATIVES AT 2,5-POSITIONS AS CDK-1 INHIBITORS (PANCREATIC CANCER) THROUGH IN SILICO STUDIES." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 869–81. https://doi.org/10.5281/zenodo.15302422.

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A range of novel 2,5-piperazino substituted pyrido[4,3-<em>d</em>]pyrimidines aiming of enriching their biological activity have been designed and synthesized through multistep process. The structures were characterized using spectroscopic techniques such as <sup>1</sup>H NMR, <sup>13</sup>C NMR, LCMS and elemental analysis. The derivatives were evaluated in silico for their potential as Cyclin Dependent Kinase-1 (CDK-1) inhibitors in pancreatic cancer. In silico ADME predictions suggested favourable drug-likeness and pharmacokinetic properties. Molecular docking against CDK1 showed that compo

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Gupta, S. K., N. Kumar, and D. Pathak. "SYNTHESIS AND BIOLOGICAL EVALUATION OF 2-SUBSTITUTED PHENYL-1-(SUBSTITUTED PIPERAZIN-1-YL) METHYL)-1H-BENZO[D]IMIDAZOLES." INDIAN DRUGS 50, no. 01 (2013): 50–58. http://dx.doi.org/10.53879/id.50.01.p0050.

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A series of biologically active benzimidazole derivatives (2a-2n) was synthesized by the reaction of o-phenylenediamine with the derivatives of benzoic acid in presence of 4N-HCl followed by the reaction with piperazine and formaldehyde to undergo Mannich reaction. The structures of all the synthesized Mannich bases were characterized by UV, FTIR, 1H NMR, mass spectroscopy and elemental analysis. The compounds were evaluated for their anthelmintic activity by the identification of paralyzing and death time by using mebendazole as standard in the concentration of 2 mg/ml. The compounds 2a, 2b,

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Costa, Fabiana Bettanin, Alane P. Cortez, Renato Ivan de Ávila, et al. "The novel piperazine-containing compound LQFM018: Necroptosis cell death mechanisms, dopamine D 4 receptor binding and toxicological assessment." Biomedicine & Pharmacotherapy 102 (June 2018): 481–93. http://dx.doi.org/10.1016/j.biopha.2018.02.120.

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