Relevant bibliographies by topics / Piperazine derivatives

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Piperazine derivatives'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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Journal articles on the topic "Piperazine derivatives"

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Yadav, Pradeep, and Y. C. Joshi. "Synthesis and Spectral Study of Novel Norfloxacin Derivatives." E-Journal of Chemistry 5, s2 (2008): 1154–58. http://dx.doi.org/10.1155/2008/357073.

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Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with variousβ-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were
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Periasamy, Mariappan, Boda Venkanna, Miriyala Nagaraju, and Lakavathu Mohan. "Methods for the Synthesis of Piperazine Derivatives Containing a Chiral Bi-2-naphthyl Moiety." Synthesis 52, no. 01 (2019): 127–34. http://dx.doi.org/10.1055/s-0037-1610731.

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Piperazine derivatives containing 1,1′-bi-2-naphthyl moiety were synthesized starting from 2,2′-dimethoxy-1,1′-bi-naphthalene via acylation using ethyl chlorooxoacetate and subsequent condensation with 1,2-diamines followed by reduction of the corresponding dihydro-2-piperazinone intermediate using the NaBH4/I2 reagent system. The corresponding chiral piperazine derivatives containing bi-2-napthyl moiety was synthesized by asymmetric reduction of ethyl dimethoxy-bi-2-naphthyloxoacetate by chiral oxazoborolidine catalyst prepared in situ using S-diphenylprolinol (S-DPP), B(OCH3)3 and H3B·THF. T
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Welz, Anna, Marcin Koba, Piotr Kośliński, and Joanna Siódmiak. "Rapid Targeted Method of Detecting Abused Piperazine Designer Drugs." Journal of Clinical Medicine 10, no. 24 (2021): 5813. http://dx.doi.org/10.3390/jcm10245813.

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Piperazine derivatives belong to the popular psychostimulating compounds from the group of designer drugs. They are an alternative to illegal drugs such as ecstasy and amphetamines. They are being searched by consumers for recreational use due to their stimulating and hallucinogenic effects. Many NPS-related poisonings and deaths have been reported where piperazines have been found. However, a major problem is the potential lack of laboratory confirmation of the involvement of piperazine derivatives in the occurrence of poisoning. Although many methods have been published, piperazine derivativ
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Prasad, H. S. Nagendra, A. P. Ananda, Amogh Mukarambi, et al. "Design, synthesis, and anti-bacterial activities of piperazine based phthalimide derivatives against superbug-Methicillin-Resistant Staphylococcus aureus." Current Chemistry Letters 12, no. 1 (2023): 65–78. http://dx.doi.org/10.5267/j.ccl.2022.9.005.

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A series of piperazine-based phthalimide derivatives 5 (a-l) were synthesized and extensively characterized using a variety of spectrum methods, including LC-MS, 1H-NMR, 13C-NMR, and FT-IR. All the derivatives were examined for their physicochemical, pharmacokinetic, bio-activity score, and PASS analysis. The 5e piperazine-based phthalimide derivative demonstrated promising antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) in the in vitro antibacterial studies. In comparison to streptomycin and bacitracin (10 µg/mL), the minimum inhibitory concentration of 5e ag
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Němečková, Dana, Eva Havránková, Jan Šimbera, Richard Ševčík, and Pavel Pazdera. "Simplified Procedure for General Synthesis of Monosubstituted Piperazines—From a Batch Reaction Vessel to a Flow (Microwave) Reactor." Molecules 25, no. 9 (2020): 2168. http://dx.doi.org/10.3390/molecules25092168.

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We reported a novel simplified synthetic procedure for the preparation of monosubstituted piperazine derivatives which can now be easily prepared in a one-pot-one-step way from a protonated piperazine with no need of introduction of a protecting group. Reactions, proceeding either at room or higher temperatures in common solvents, involve heterogeneous catalysis by metal ions supported on commercial polymeric resins. A general synthetic scheme was successfully applied to afford a wide range of monosubstituted piperazines. Furthermore, we picked up a set of piperazine derivatives and studied th
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Erdag, Emine. "A New Tick on the Clock: Indole-Based Optimization of Melatonin Receptor Modulators." Chronobiology in Medicine 7, no. 2 (2025): 88–94. https://doi.org/10.33069/cim.2025.0014.

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Objective: Melatonin is a key regulator of circadian rhythms and sleep-wake cycles, exerting its effects through MT1 and MT2 receptors. Despite the clinical use of selective MT1/MT2 agonists, their short half-lives, low bioavailabilities, and rapid first-pass metabolism limit their efficacy in sleep and circadian rhythm disorders. This study aimed to identify and evaluate novel piperazine-substituted indole derivatives with enhanced receptor binding, prolonged systemic circulation, and improved pharmacokinetic properties as potential next-generation melatonin receptor modulators.Methods: Seven
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Verma, Arvind Kumar, Arun Kumar, and Kunwar Abhishek Singh. "Synthesis and molecular docking for anticonvulsant activity of some new benzoxazole derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 551. https://doi.org/10.59467/ijhc.2025.35.551.

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To explore the anticonvulsant action related to the benzoxazole framework, a series of benzoxazole-piperazine derivatives, namely N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-(piperazin-1-yl) acetamides (3a-e) (3), was synthesized by reacting N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-chloroacetamide (2) with various substituted piperazines. Molecular docking studies were conducted using Auto Dock Vina 1.5.7 to evaluate the compounds' binding affinities with anticonvulsant-related targets protein data bank ID: 3PO7, 7WLJ, using zonisamide as a standard drug to ensure their potential. Several compounds exhibit
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Jílek, Jiří, Jiří Holubek, Emil Svátek, et al. "Potential metabolites of the neuroleptic agents belonging to the 8-methylthio-10-piperazino-10,11-dihydrodibenzo[b,f]thiepin series; Synthesis of 2-hydroxy and 3-hydroxy derivatives." Collection of Czechoslovak Chemical Communications 50, no. 10 (1985): 2179–90. http://dx.doi.org/10.1135/cccc19852179.

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The acid VI, prepared by reaction of potassium salts of (2-iodo-5-methoxyphenyl)acetic acid and 4-(methylthio)thiophenol in the presence of copper, was transformed via intermediates VII-IX to 2-methoxy-8-methylthio-10-piperazino-10,11-dihydrodibenzo[b,f]thiepins X and XI. Their demethylation with boron tribromide afforded 2-hydroxy derivatives of the neuroleptic agents methiothepin and oxyprothepin I and II. 11-Chloro-7-methoxy-2-methylthio-10,11-dihydrodibenzo[b,f]thiepin was subjected to substitution reactions with 1-methylpiperazine and 1-(ethoxycarbonyl)piperazine and gave piperazine deriv
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Varadaraju, Kavitha Raj, Jajur Ramanna Kumar, Lingappa Mallesha, et al. "Virtual Screening and Biological Evaluation of Piperazine Derivatives as Human Acetylcholinesterase Inhibitors." International Journal of Alzheimer's Disease 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/653962.

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The piperazine derivatives have been shown to inhibit human acetylcholinesterase. Virtual screening by molecular docking of piperazine derivatives 1-(1,4-benzodioxane-2-carbonyl) piperazine (K), 4-(4-methyl)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S1), and 4-(4-chloro)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S3) has been shown to bind at peripheral anionic site and catalytic sites, whereas 4-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S4) and 4-(2,5-dichloro)-benzenesulfonyl-1-(1,4-benzodioxane-2-carbonyl) piperazine (S7) do not bind eith
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Wu, Yuet, Silvia Parapini, Ian Williams, et al. "Facile Preparation of N-Glycosylated 10-Piperazinyl Artemisinin Derivatives and Evaluation of Their Antimalarial and Cytotoxic Activities." Molecules 23, no. 7 (2018): 1713. http://dx.doi.org/10.3390/molecules23071713.

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According to the precepts that C-10 amino-artemisinins display optimum biological activities for the artemisinin drug class, and that attachment of a sugar enhances specificity of drug delivery, polarity and solubility so as to attenuate toxicity, we assessed the effects of attaching sugars to N-4 of the dihydroartemisinin (DHA)-piperazine derivative prepared in one step from DHA and piperazine. N-Glycosylated DHA-piperazine derivatives were obtained according to the Kotchetkov reaction by heating the DHA-piperazine with the sugar in a polar solvent. Structure of the D-glucose derivative is se
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Dissertations / Theses on the topic "Piperazine derivatives"

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Silva, Daiany Priscilla Bueno da. "Atividade anti-inflamatória e antinociceptiva de 4-((1-fenil-1h-pirazol-4-il) metil) piperazina-1-carboxilato: um novo derivado piperazínico." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5497.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-20T13:30:13Z No. of bitstreams: 2 Dissertação - Daiany Priscilla Bueno da Silva - 2015.pdf: 1122736 bytes, checksum: fc98524b1ad5d0e3a0cb2e1cc87bc933 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-20T13:32:30Z (GMT) No. of bitstreams: 2 Dissertação - Daiany Priscilla Bueno da Silva - 2015.pdf: 1122736 bytes, checksum: fc98524b1ad5d0e3a0cb2e1cc87bc933 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a771
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Rodrigues, Oscar Romero Lopes. "Avaliação farmacológica no sistema nervoso central de um novo derivado piperazínico LQFM 104." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4888.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2015-11-12T18:44:31Z No. of bitstreams: 2 Dissertação - Oscar Romero Lopes Rodrigues - 2015.pdf: 1210572 bytes, checksum: 9080ec829a41c8754d39489573c4cd56 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2015-11-12T18:46:20Z (GMT) No. of bitstreams: 2 Dissertação - Oscar Romero Lopes Rodrigues - 2015.pdf: 1210572 bytes, checksum: 9080ec829a41c8754d39489573c4cd56 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a771
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Shey, Jing-Ying, and 徐錦英. "Soluble Polymer-Supported Combinatorial Synthesis Piperidine and Piperazine Derivatives." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/20405295067465780839.

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碩士<br>國立東華大學<br>化學研究所<br>87<br>Abstract Combinatorial synthesis of chemistry libraries is undergoing rapid examination as a tool to enhance drug research and development. While it appears obvious that combinatorial chemistry strategies offer the potential to enhance drug development by shortening the time to optimize a new lead by structure-activity relationship (SAR) studies, it is often less appreciated that the greatest value of combinatorial chemistry strategies lies in its potential to enhance discovery of novel leads or pharma- cophores. The development of both
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Chen, Chih-Hao, and 陳致豪. "Supramolecules of 1,3,5-Triazine and Piperazine Derivatives : Synthesis and Study." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/2m5z39.

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碩士<br>國立暨南國際大學<br>應用化學系<br>103<br>This thesis reports the synthesis of organic supramolecules containing 1,3,5-triazine and piperazine units. We used acyl amine groups at 1 and 3 positions of the benzene ring as the starting groups to react with nitrogen-containing compounds or cyanuric chloride for preparing molecules with different core structures and different peripheral functionalities to control their stacking in the solid state. Thus a series of organic supramolecules were obtained by H-bond self-assembling interaction and then a representing sample was studied in the solid state by sing
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Huleatt, Paul Brady. "Functionalisation of piperazine-2,5-diones : towards the synthesis of scabrosin esters." Phd thesis, 2004. http://hdl.handle.net/1885/148549.

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Chen, Xi 1981. "Carbon dioxide thermodynamics, kinetics, and mass transfer in aqueous piperazine derivatives and other amines." Thesis, 2011. http://hdl.handle.net/2152/ETD-UT-2011-08-4312.

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To screen amine solvents for application in CO2 capture from coal-fired power plants, the equilibrium CO2 partial pressure and liquid film mass transfer coefficient were characterized for CO2-loaded and highly concentrated aqueous amines at 40 – 100 °C over a range of CO2 loading with a Wetted Wall Column (WWC). The acyclic amines tested were ethylenediamine, 1,2-diaminopropane, diglycolamine®, methyldiethanolamine (MDEA)/Piperazine (PZ), 3-(methylamino)propylamine, 2-amino-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol/PZ. The cyclic amines tested were piperazine derivatives including
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Chung, Wen-Hsuan, and 鍾文軒. "1. Synthetic Studies Toward Vitamin B6 Derivatives (dmaPM) and Actinidine2. Synthetic Studies Toward Piperazine-2,5-diones Skeleton." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/34248436322255936218.

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Huang, Chun-Sheng, and 黃俊昇. "Amphiphatic Pyrazine, Pyridine and Piperazine Derivaties as the Thermal Latency for Epoxy-Phenolic Resins." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/00894868796996959698.

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碩士<br>國立成功大學<br>化學系碩博士班<br>96<br>Novel amphiphatic piperazine, pyrazine, and pyridine compounds were evaluated as thermal latent catalysts for the polymerization of diglycidyl ether of bisphenol A (DGEBA). Amphiphatic piperazine, pyrazine, and pyridine compounds 18-23 were used to cure epoxy resin systems to investigate their thermal latency and storage stability. Cationic latent thermal BHP (3, N-benzylpyrazinium hexafluoroantimonate) was investigated as model reaction of epoxy resin systems with respect to the thermal latency and storage stability of the amphiphatic piperazine, pyrazine, a
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Yeh, Wen-Pin, and 葉文賓. "Microwave-Assisted Traceless Synthesis of Disubstituted Indole Alkaloids, pyrrolo[3,2-c]quinolines and Piperazino-Oxazinones derivatives." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/31966988632514439734.

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博士<br>國立東華大學<br>化學系<br>96<br>This thesis illustrates the use of Microwave technology for the synthesis of tetrahydro-β-carbolinehydantoins, 2,5-diketo piperazine functionalized β-carboline, pyrrolo[3,2-c]quinolines, and N-Cyanoamide substituted Piperazino-Oxazinones, which provides access to the structurally diverse collection of biologically active molecules. The work in this thesis is presented in the following four parts. The first part makes use of PEG linked Boc tryptophan to construct the β-carboline skeleton via the Pictet-Spengler reaction using a variety of aldehydes. Reaction of thes
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Saeed, Muhammad [Verfasser]. "Total syntheses of R-(-)-argentilactone, S-(+)-argentilactone, R-(-)-massoilactone, (5S,6R)-O-acetylosmundalactone as-triazin-, trithiocarbonate- and 4-(4-substituted-1-piperazinyl) derivatives from sugar templates = Totalsynthesen von R-(-)-Argentilacton, S-(+)-Argentilacton, R-(-)-Massoilacton, (5S,6R)-O-Acetylosmundalacton as-Triazin-, Trithiocarbonat- und 4-(4-substituierten 1-Piperazinyl)-Derivaten aus Zucker-Templaten / vorgelegt von Muhammad Saeed." 2001. http://d-nb.info/963217488/34.

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Books on the topic "Piperazine derivatives"

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Derivatives of Piperazine IV . . Creative Media Partners, LLC, 2021.

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Bain, Joseph Paul 1914. Derivatives of Piperazine VIII: Synthesis of Substituted Piperazines and Reactions of Piperazines with Conjugated Systems. Creative Media Partners, LLC, 2021.

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Derivatives of Piperazine IX: Syntheses with Alkene Oxides. Creative Media Partners, LLC, 2021.

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Stewart, Vincent Evans 1913. Derivatives of Piperazine and Morpholine I: Addition to Alpha, Beta-Unsaturated Ketones. Creative Media Partners, LLC, 2021.

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Braun, John Charles 1917. Derivatives of Piperazine, XV: The Kindler Modifiation of the Willgerodt Reaction Using Phenylpiperazines. Creative Media Partners, LLC, 2021.

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Robbins, Robert 1916. Derivatives of Piperazine, XI: Addition of 1-Arylpiperazines to Alpha, Beta-Unsaturated Nitriles and Esters. Creative Media Partners, LLC, 2021.

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Book chapters on the topic "Piperazine derivatives"

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Wills, Brandon, and Timothy Erickson. "Psychoactive Phenethylamine, Piperazine, and Pyrrolidinophenone Derivatives." In Medical Toxicology of Drug Abuse. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118105955.ch10.

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Kovács, József, István Pintér, László Jicsinszky, Natascha Roos, and Alain Marsura. "Symmetrical and Non-Symmetrical Urea Derivatives of ß-Cyclodextrin and Piperazine: Application in Capillary Electrophoresis." In Proceedings of the Ninth International Symposium on Cyclodextrins. Springer Netherlands, 1999. http://dx.doi.org/10.1007/978-94-011-4681-4_11.

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Yamamoto, Koki. "Development of NK3R Antagonists with a Degradable Scaffold in the Natural Environment: Synthesis and Application of Fused Piperazine Derivatives for Investigation of Degradable Core Motifs." In Structure–Activity Relationships for Development of Neurokinin-3 Receptor Antagonists. Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2965-8_3.

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Gee, Paul, and Leo Schep. "1-Benzylpiperazine and other Piperazine-based Derivatives." In Novel Psychoactive Substances. Elsevier, 2013. http://dx.doi.org/10.1016/b978-0-12-415816-0.00008-0.

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Schep, L. J., H. A. Poulsen, and P. Gee. "Detection of Misused Drugs: Psychoactive Piperazines." In Detection of Drug Misuse: Biomarkers, Analytical Advances and Interpretation. The Royal Society of Chemistry, 2017. http://dx.doi.org/10.1039/9781782621577-00100.

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In recent years, a new class of psychoactive drugs, predominantly causing adrenergic-like effects, has emerged in the market. They are identified by their piperazine backbone, possess a bridge to either a phenyl or benzyl group and are loosely defined as phenyl- and benzyl-piperazines, respectively. Detection of these drugs has traditionally focused on gas chromatography mass spectrometry assays, but these are being replaced by various liquid chromatography mass spectrometers, which enable greater resolution of the ion transition fragments and allow the identification of a wider range of recre
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Ohtaka, Hiroshi. "Applications of quantitative structure-activity relationships to drug design of piperazine derivatives." In Pharmacochemistry Library. Elsevier, 1995. http://dx.doi.org/10.1016/s0165-7208(06)80058-9.

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Prakash, G. K. S., and J. Hu. "Using Silylated and Non-Silylated Piperazino Hemiaminals of ­Trifluoroacetaldehyde." In Three Carbon-Heteroatom Bonds: Amides and Derivatives; Peptides; Lactams. Georg Thieme Verlag KG, 2005. http://dx.doi.org/10.1055/sos-sd-022-00739.

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Conference papers on the topic "Piperazine derivatives"

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Gupta, Mayuri, Hallvard F. Svendsen, and Eirik Falck Da Silva. "Temperature sensitivity of piperazine and its derivatives using polarizable continuum solvation model." In 2010 2nd International Conference on Chemical, Biological and Environmental Engineering (ICBEE). IEEE, 2010. http://dx.doi.org/10.1109/icbee.2010.5653461.

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Lindahl, R., A. Ostin, J. Levin, and M. Sundgren. "359. LC-MS/MS Analysis of Diisocyanates as 1-(2-Methoxyphenyl) Piperazine Derivatives." In AIHce 2000. AIHA, 2000. http://dx.doi.org/10.3320/1.2763708.

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Ananth, Arjun H., and Senthamaraikannan Kabilan. "Synthesis, In Silico and In Vitro Studies of 7-Methxy-3-((4-phenyl piperazin-1-yl)methyl)-2H-chromen-2-one Analogues as Derivatives as Anti-Prostate Cancer Agents." In ECMC 2022. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13179.

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