Relevant bibliographies by topics / Piperazine Piperazine Drugs Rats Rats

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Academic literature on the topic 'Piperazine Piperazine Drugs Rats Rats'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Piperazine Piperazine Drugs Rats Rats"

1

Delon, Annie, Serge Bouquet, Francois Huguet, Valerie Brunet, Philippe Courtois, and William Couet. "Pharmacokinetic-Pharmacodynamic Contributions to the Convulsant Activity of Fluoroquinolones in Rats." Antimicrobial Agents and Chemotherapy 43, no. 6 (1999): 1511–15. http://dx.doi.org/10.1128/aac.43.6.1511.

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ABSTRACT The in vivo convulsant activities in rats of five representative fluoroquinolones (FQs), norfloxacin, enoxacin, sparfloxacin, fleroxacin, and pefloxacin, were compared. The experimental approach allowed distinction between the drugs’ ability to reach the pharmacological receptors at the level of the central nervous system (pharmacokinetic contribution) and their ability to interact with these receptors (pharmacodynamic contribution). The presence of a methyl group on the piperazine moiety decreased the pharmacodynamic contribution to the convulsant activity by severalfold, and the rat
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Васина, Е. Ю., С. Г. Чефу, and Н. Н. Петрищев. "The effect of Notrombel on FeCl3-induced carotid artery thrombosis in rats." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 2() (May 27, 2019): 50–55. http://dx.doi.org/10.25557/0031-2991.2019.02.50-55.

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Цель работы - изучение влияния Нотромбела (ЗАО «Вертекс», Санкт-Петербург, РФ) на развитие экспериментального тромбоза. Методика. Опыты выполнены на крысах-самцах Вистар массой 250-270 г. Нотромбел вводили внутривенно и интрагастрально в течение 10 сут (курсовая доза 25, 50 и 100 мг/кг). В качестве препаратов сравнения использовали ацетилсалициловую кислоту (АСК) и Клопидогрел (курсовая доза 10,5 и 20 мг/кг соответственно). Тромбоз сонной артерии вызывали 60-секундной аппликацией 20% FeCl3. Кровоток регистрировали методом высокочастотной ультразвуковой допплерографии («Минимакс-Допплер-К» Санк
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Kubacka, Monika, Szczepan Mogilski, Monika Zadrożna та ін. "MH-76, a Novel Non-Quinazoline α1-Adrenoceptor Antagonist, but Not Prazosin Reduces Inflammation and Improves Insulin Signaling in Adipose Tissue of Fructose-Fed Rats". Pharmaceuticals 14, № 5 (2021): 477. http://dx.doi.org/10.3390/ph14050477.

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Background: Quinazoline α1-adrenoceptors antagonists have been shown to exert moderately favorable effects on the metabolic profile in hypertensive patients. However, based on AntiHypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) results, they are no longer recommended as a first line therapy of hypertension. Recent studies have shown that quinazoline-based α1-adrenoceptors antagonists (prazosin, doxazosin) induce the apoptosis and necrosis, which may be responsible for ALLHAT outcomes; however, these effects were proven to be independent of α1-adrenoceptor block
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van Lookeren Campagne, Menno, Jeroen B. Verheul, Klaas Nicolay, and Robert Balázs. "Early Evolution and Recovery from Excitotoxic Injury in the Neonatal Rat Brain: A Study Combining Magnetic Resonance Imaging, Electrical Impedance, and Histology." Journal of Cerebral Blood Flow & Metabolism 14, no. 6 (1994): 1011–23. http://dx.doi.org/10.1038/jcbfm.1994.133.

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We explored the therapeutic potentials of two N-methyl-d-aspartate (NMDA) receptor antagonists in vivo using different techniques. NMDA injected into the striatum of neonatal rats (20 nmol/0.5 μl) induced a rapid increase in the diffusion-weighted (DW) image intensity, spreading over a large part of the ipsilateral hemisphere. Subcutaneous injection of the NMDA receptor antagonist MK-801 (1 mg/kg) or d-( E)-4-(3-phosphono-2-prop-enyl)-2-piperazine-carboxylic acid (D-CPPene; 1.5 mg/kg) reversed both the volume and the grading of the NMDA-induced hyperintensity of DW images, the reversal by MK-8
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Jiang, Xiaomei, Xiaomei Ling, Fangbin Han, Runtao Li, and Jingrong Cui. "Studies on the metabolism of 4-methyl-piperazine-1-carbodithioc acid 3-cyano-3,3-diphenylpropyl ester hydrochloride in rats by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry." Journal of Pharmaceutical and Biomedical Analysis 44, no. 5 (2007): 1127–32. http://dx.doi.org/10.1016/j.jpba.2007.05.026.

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Manzini, Stefano, Francesca Perretti, Paola Boni, Gabriele Barbanti, Damiano Turini, and Carlo Alberto Maggi. "In vitro and in vivo studies on the effects of the alpha-adrenoceptor blocker IP/66 (1-(2-ethoxy-2-(3? -pyridyl)ethyl)-4-(2?-methoxy-phenyl)piperazine) on urethral tone in rats." Drug Development Research 23, no. 1 (1991): 35–46. http://dx.doi.org/10.1002/ddr.430230104.

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Ismail, Djauhar, Utomo Utomo, Sugeng Yuwono, and Noerhayati S. "The Use of Anthelmintics in the Treatmenlt of Ascariasis." Paediatrica Indonesiana 16, no. 9-10 (2019): 391–5. http://dx.doi.org/10.14238/pi16.9-10.1976.391-5.

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Ninety-seven children with Ascariasis were treated at randomly with Piperazine, Tetramisole, and Pyrantel pamoate in a single dose with cure rates of 59%, 62%, and 88%, respectively. In the children who were not cured, a reduction in egg count of nearly 80% was found in all three treatment groups. The results of this study showed that Pyrantel pamoate is the most effective of the three drugs.
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8

Zenner, Lionel. "Effective eradication of pinworms (Syphacia muris, Syphacia obvelata and Aspiculuris tetraptera) from a rodent breeding colony by oral anthelmintic therapy." Laboratory Animals 32, no. 3 (1998): 337–42. http://dx.doi.org/10.1258/002367798780559202.

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An oral combination of piperazine and ivermectin was used over a 6-week period for treating three different colonies of mice or rats infested with Syphacia obvelata, Syphacia muris or Aspiculuris tetraptera. No acute toxic effect was found in transgenic lines of mice or rats with these products in a preliminary trial. The colonies were treated with piperazine, 2.1 mg/ml in tap water for 2 weeks, then with ivermectin, 0.007 mg/ml, in tap water for the third and fourth weeks, and finally with piperazine for two further weeks. Hygiene measures such as a complete cage change, thorough disinfection
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Sasamori, Hitomi, Naoya Nishitani, Yu Ohmura, and Mitsuhiro Yoshioka. "Blonanserin and 1-(2-Pyriidinyl)-piperazine suppress impulsive action in rats." Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (2021): 3—P1–25. http://dx.doi.org/10.1254/jpssuppl.94.0_3-p1-25.

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Kim, Eun-Yeong, Keewon Yu, Kyungmi Choi, Hyung Eun Yu, Soo Jin Oh, and Kiho Lee. "Effect of Piperazine Dithioctate on the Oral Pharmacokinetics of Glimepiride in Rats." Biological & Pharmaceutical Bulletin 38, no. 8 (2015): 1161–68. http://dx.doi.org/10.1248/bpb.b15-00044.

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Dissertations / Theses on the topic "Piperazine Piperazine Drugs Rats Rats"

1

Aitchison, Lara. "Exposure to benzylpiperazine (BZP) in adolescent rats : adulthood changes in anxiety-like behaviour : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Psychology /." 2006. http://library.canterbury.ac.nz/etd/adt-NZCU20060721.121511.

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Perry, James C. "Adulthood outcomes in rats following repeated adolescent exposure to 1-benzylpiperazine (BZP) and/or ethanol : a thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Psychology /." 2008. http://hdl.handle.net/10092/1610.

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