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Dissertations / Theses on the topic 'Piperazine'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Moura, Rebeca Garcia. "Síntese de um fragmento precursor do Indinavir." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-11042017-075910/.

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Considerando-se a necessidade brasileira de se obterem fármacos a preços competitivos e usando tecnologia nacional, visamos sintetizar um fragmento do Indinavir empregando como material de partida a L-serina, um aminoácido natural de baixo custo. Desta maneira, desenvolvemos a seguinte rota, em 6 etapas: p-tosilação da serina, pelo uso de cloreto de p-tosila / NaOH; amidação da p-tosilserina, empregando-se o sal de terc-butilamônio da N-hidroxissuccinimida / DCC; ciclização da (S)-2-terc-butil-N-p-tosilserina, em condição de transferência de fase, com cloreto de p-tosila / carbonato de potássi
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2

Monaghan, S. M. "Synthetic studies in the piperazine-2,5-dione area." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47304.

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3

Uddin, Farid. "Use of piperazine ligands for bleaching and epoxidation catalysis." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/692.

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Following reports that the dinuclear manganese complex of the ligand 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane (TMTACN) was a potent bleaching catalyst, its catalytic oxidative activity was thoroughly studied. Apart from its catalytic bleaching activity, it has shown to be a versatile catalyst in terms of its substrate scope. In bleaching, it still remains the benchmark with regards to its catalytic bleaching activity against which systems in development are compared. Chapter one discusses the need for a bleaching catalyst in detergent formulations and the advantages it offers over existing
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4

Kuleya, Chipo. "The synthesis, analysis and characterisation of piperazine based drugs." Thesis, Anglia Ruskin University, 2014. https://arro.anglia.ac.uk/id/eprint/579889/1/Thesis%20%20final%20-%20Chipo%20Kuleya%20July%202015.pdf.

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This study developed a GC-MS method for the simultaneous detection of piperazines and congeners in street samples of amphetamine type stimulants. This research investigated the clandestine routes of synthesis and chemical profiles of phenylpiperazines, represented by 1- (4-fluorophenyl)piperazine (4-FPP) and 1-(3-trifluoromethylphenyl)piperazine (3-TFMPP). These drugs are part of the increasingly prevalent illicit new psychoactive substances. The presence of (2, 3, 4) FPP and (2, 3, 4) TFMPP positional isomers has been identified by other researchers as a limitation due to their similar
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5

Kuleya, Chipo. "The synthesis, analysis and characterisation of piperazine based drugs." Thesis, Anglia Ruskin University, 2014. http://arro.anglia.ac.uk/579889/.

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This study developed a GC-MS method for the simultaneous detection of piperazines and congeners in street samples of amphetamine type stimulants. This research investigated the clandestine routes of synthesis and chemical profiles of phenylpiperazines, represented by 1- (4-fluorophenyl)piperazine (4-FPP) and 1-(3-trifluoromethylphenyl)piperazine (3-TFMPP). These drugs are part of the increasingly prevalent illicit new psychoactive substances. The presence of (2, 3, 4) FPP and (2, 3, 4) TFMPP positional isomers has been identified by other researchers as a limitation due to their similar chemic
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6

Khan, Abdul Majeed 1980. "Síntese e termoquímica de adutos de brometos de metais bivalentes com aminas hetrocíclicas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249123.

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Orientador: Pedro Oliver Dunstan Lozano<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T07:28:40Z (GMT). No. of bitstreams: 1 Khan_AbdulMajeed_D.pdf: 3004508 bytes, checksum: 1d8c778094bf0cb1b93fa7bf80e19074 (MD5) Previous issue date: 2013<br>Resumo: Os adutos MX2.nL (M = Mn, Fe, Co, Ni, Cu ou Zn, L = 3-cianopiridina, piperidina ou piperazaina, X = Br, n = 0,5, 0,75, 1, 1,5, 2 ou 4), foram sintetizados e caracterizados através de análise elementar, determinação de pontos de fusão, espectroscopia IV e eletrônica e análise
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7

Bishnoi, Sanjay. "Carbon dioxide absorption and solution equilibrium in piperazine activated methyldiethanolamine /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004215.

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8

Safko, Jason P. "Luminescent Nitrogen and Sulfure Adducts of CuI Disubstituted Piperazine Complexes." W&M ScholarWorks, 2012. https://scholarworks.wm.edu/etd/1539626933.

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9

Tavet, Fabrice. "Nouveaux derives de la piperazine : synthese, relation structure-activite, proprietes pharmacologiques." Paris 5, 1991. http://www.theses.fr/1991PA05P617.

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10

Jakobsson, Josef. "Molecular mechanisms underlying platelet inhibition obtained by novel piperazine-purine analogues." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93312.

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Introduction. MK-substances are a new class of piperazine-purine analogues bearing nitrate esters with confirmed cardioprotective, anti-inflammatory and antithrombotic effects. The length of the carbon side chain (spacer) connecting the nitrate ester to the basic molecular structure seems to be of importance for the platelet inhibitory effect but the molecular mechanisms underlying this are not yet fully understood. Aim. Establish molecular evidence explaining the observed differences in platelet inhibition obtained by a new group of piperazine-purine analogues with different spacer length. Me
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11

SEFRAOUI, EL HOURINE. "Synthese et etude biologique de derives butyriques dans la serie des piperazines." Amiens, 1992. http://www.theses.fr/1992AMIEP047.

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12

Lamouri, AAzdine. "Antagonistes du paf derives de la piperazine synthese, pharmaco-toxicologie et structure-activite." Paris 7, 1990. http://www.theses.fr/1990PA077205.

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Le platelet activating factor (paf) est un ether-phospholipide implique dans de nombreux phenomenes physiopathologiques tels que l'inflammation et l'allergie. A partir de l'etude des cartes de potentiels electrostatiques a 3d d'antagonistes connus de cet autocoide, une premiere hypothese sur les fonctionnalites du recepteur a ete faite. Ce modele nous a permis de preparer une nouvelle classe d'antagonistes: les n,n-bis-trimethoxy-3,4,5-benzoyl piperazines substituees en position 2. En termes d'agregation plaquettaire comme de binding, nous avons obtenu des molecules antagonistes, dont les acti
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13

Viana, Fernando Andrà Campos. "Estudo comparativo, randomizado para avaliar a eficÃcia terapÃutica da piperazina hexahidratada com extrato fluido de rhamnus purshiana no tratamento da ascaridÃase." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=646.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A eficÃcia e a seguranÃa terapÃutica de um medicamento a base de piperazina hexahidratada associada com o extrato fluido de Rhamnus purshiana (DM IndÃstria FarmacÃutica) usada como tratamento anti-helmÃntico em pacientes no CearÃ, Brasil, foi testado em comparaÃÃo com o produto composto de piperazina sem qualquer associaÃÃo (DM IndÃstria FarmacÃutica). Um estudo prospectivo, randomizado, controlado e duplo cego, comparando taxas de cura para infecÃÃo por Ascaris lunbricoides. Amostras coprolÃgicas de 990 pacientes foram coletadas
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14

Walker, Roderick Bryan. "HPLC analysis and pharmacokinetics of cyclizine." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1003279.

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The investigations detailed in this dissertation have been conducted to address the paucity of pharmacokinetic information, in published literature, pertaining to cyclizine. The areas of investigation have included the selective quantitation of both cyclizine and its demethylated metabolite, norcyclizine in serum and urine, assessment of stability of both compounds in stored biological samples, dosage form analysis, dissolution rate testing of tablets, and bioavailability and pharmacokinetics following administration of an intravenous solution, and tablets to humans. High-performance liquid ch
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15

Vasconcelos, Leonardo de. "Síntese de um fragmento precursor do fármaco Indinavir." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-23042013-141617/.

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Neste trabalho foram aprofundados nossos estudos para obtenção da (S)-2-terc-butilamida-4-(3-picolil)piperazina, pela abertura da (S)-2-terc-butilcarboxamida-N-p-tosilaziridina seguida de ciclização, em 78% de rendimento, com o triflato de vinildifenilsulfônio. A aziridina foi preparada por um processo de ciclização, em condições de transferência de fase, partindo-se da L-serina, um aminoácido natural de baixo custo. Esta rota sintética rendeu um material que apresenta a mesma estereoquímica S do fragmento piperazínico usado na síntese do Indinavir, podendo vir a constituir uma via alternativa
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16

Maignan, Jordany Richarlson. "Development of Orally Bioavailable 4(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones with Potent Anti-malarial Activity." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5873.

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Although Malaria rates are on the decline due to the efforts of the World Health Organization and other organizations dedicated to the eradication of this disease, a relaxed attitude towards the development of new antimalarial entities would be flawed. Due to the emergence of resistance in the parasite, the almost 50% world-wide reduction in malarial death rates that have been produced over the past 15 years are threatening to be lost New drugs are urgently needed and our approach focuses on the re-evaluation and optimization of the historic antimalarial ICI 56,780. Due to its causal prophylac
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17

Gao, Rong. "DESIGN, SYNTHESIS AND EVALUATION OF NOVEL MUSCARINIC LIGANDS." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/232219.

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Pharmaceutical Sciences<br>Ph.D.<br>Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves. Although five mAChR subtypes (M1-M5) share a high degree of homology, they display different physiological effects including controlling smooth muscle tone to neurotransmitter release in the CNS. Hence these receptor subtypes have been investigated as potential therapeutic targets for agents capable of treating Alzheimer's Disease, Parkinson's Disease, peptic ulcer disease, COPD, urinary incontinence, and muscle spasms. Our in
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18

Tendjoun, Victor. "Synthese d'aminoacides et derives precurseurs d'hydantoines et de piperazine-2,5-diones spiranniques potentiellement immunomodulateurs (doctorat : sciences pharmaceutiques)." Besançon, 1997. http://www.theses.fr/1997BESA3516.

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19

Nsanzubuhoro, Consolata Nsanzimpaka. "Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents." Master's thesis, Faculty of Science, 2018. http://hdl.handle.net/11427/30112.

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The emergence and spread of parasites resistant to first-line antimalarial drugs comprising artemisinin combination therapies (ACTs) threaten malaria control. There is therefore a need to develop novel and chemically diverse alternatives that are safe, efficacious, and able to circumvent drug resistance. Schistosomiasis is the second most prevalent tropical disease in the world after malaria, and treatment relies on a single drug: praziquantel. Although praziquantel shows multiple benefits over drugs previously used to treat schistosomiasis, dependence on it will result in therapeutic limitati
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20

Goossens, Laurence. "Conception, synthese et etude de nouveaux ligands des recepteurs nk1 de la substance p (doctorat : pharmacochimie)." Lille 2, 2000. http://www.theses.fr/2000LIL2P254.

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21

Numa, Mehdi Michel Djamel. "Synthesis of a #NU#, #NU#'-dialkyl piperazine #NU#, #NU#,-dioxide #bait and switch' hapten for proteolytic antibodies." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247571.

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22

RONDU, FREDERIC. "Synthese et etude pharmaco-toxicologique de derives de la piperazine actifs sur le diabete non-insulino-dependant." Paris 7, 1996. http://www.theses.fr/1996PA077120.

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Le diabete non-insulino-dependant se caracterise notamment par un dysfonctionnement de la regularion nerveuse de la secretion d'insuline par les cellules b du pancreas. Nous avons ainsi envisage la synthese de nouvelles molecules antagonistes du recepteur alpha-2 en nous appuyant sur une etude prealable de modelisation moleculaire. Tous les composes ont ete testes in vivo sur un modele de rat non-insulino-dependant et ont fait l'objet d'une etude in vitro sur les recepteurs alpha-2, i1 et i2. Une molecule s'est averee particulierement interessante et nous permet d'envisager la decouverte d'une
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23

Fang, Fang. "Synthesis of Bicyclic and Tricyclic Analogues of Oxazolidinone." Ohio University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1357312054.

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24

Robie, Taylor A. "Improved Electrolyte-NRTL Parameter Estimation Using a Combined Chemical and Phase Equilibrium Algorithm." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1368027260.

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25

Anderson, Laura. "Design and Synthesis of Substituted 1,4-Hydrazine-linked Piperazine-2,5- and 2,6-diones and 2,5-Terpyrimidinylenes as α-Helical Mimetics". Scholar Commons, 2009. https://scholarcommons.usf.edu/etd/1830.

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The most common secondary structure of proteins is the alpha-helix. The alpha-helix can be involved in various protein-protein interactions (PPIs) through the recognition of three or more side chains along one face of the alpha-helix (Wells and McClendon, 2007). In recent years, there has been an increasing interest in the development of peptidic and non-peptidic compounds that bind to PPI surfaces. We focused on the design and synthesis of compounds that mimic the orientation of side chain residues of an alpha-helical protein domain. Although our scaffolds could potentially inhibit various PP
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Dib, Hanna. "Dendrimères modifiables par stimulation : vers des catalyseurs adaptables." Toulouse 3, 2013. http://www.theses.fr/2013TOU30191.

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Les travaux de cette thèse concernent la synthèse de nouveaux catalyseurs dendritiques qui répondent a un stimulus externe. Outre les avantages des dendrimères qui, grâce à leurs propriétés particulières, peuvent apporter un changement d'activité par rapport à leurs analogues non supportés dans des réactions catalytiques, l'addition d'un groupe commutable à l'intérieur de la structure dendritique ou du ligand greffé, peut donner un aspect original au dendrimères en catalyse. Le chapitre d'introduction est une mise au point bibliographique concernant l'activité de catalyseurs répondant à un sti
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Jumani, Rajiv Satish. "Methods To Identify And Develop Drugs For Cryptosporidiosis." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/892.

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Cryptosporidiosis is a common diarrheal disease caused by intestinal infection with the apicomplexan parasite Cryptosporidium, in humans usually either with C. hominis or C. parvum. Unfortunately, given a large burden of disease in children and immunocompromised people like AIDS patients, the only currently approved treatment, nitazoxanide, is unreliable for these patient populations. To address the urgent need for new drugs for the most vulnerable populations, large phenotypic screening efforts have been established to identify anti-Cryptosporidium growth inhibitors in vitro (hits). However,
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28

Andersson, Hans. "Reaction between grignard reagents and heterocyclic N-oxides synthesis of substituted pyridines, piperidines and piperazines /." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25619.

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29

El-Sayed, Mohamed. "Functional Aromatic Amino Ketones as UV/Vis probes for various liquid and solid environments." Doctoral thesis, Universitätsbibliothek Chemnitz, 2003. http://nbn-resolving.de/urn:nbn:de:swb:ch1-200300948.

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Zum gegenwärtigen Kenntnisstand bezüglich Solvatochromie, Sol-Gel Prozesse, und der Synthese von Polyketonen wird eine kurze Einführung gegeben. Die Synthesekonzeptionen funktionalisierter aromatischer Aminoketone wereden vorgestellt. Die neun Verbindungen wurden mittels Elementaranalyse, Röntgenstrukturanalyse, und spektroskopischen (NMR, UV/Vis, MS) Methoden aufgeklärt. Im Mittelpunkt der Untersuchungen steht die Untersuchung des Einflusses von unterschiedlichen Medien (Lösungmittel, Oberflächen, Sol-Gel Materialien und Nachbarnmoleküle im Kristall) auf die Lage der UV/Vis-Absorptionsmaxima
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Rodrigues, Oscar Romero Lopes. "Avaliação farmacológica no sistema nervoso central de um novo derivado piperazínico LQFM 104." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/4888.

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Le, Bihan Gae͏̈lle. "Synthèse et étude structure-activité d'hétérocycles azotés actifs sur le diabète non-insulino-dépendant." Paris 5, 1997. http://www.theses.fr/1997PA05P603.

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32

PIARRAUD, ANNETTE. "Synthese rapide de molecules marquees avec un atome emetteur de positons : la (#1#1c)fotemustine (une nitrosouree) et le (#1#8f)gbr 12936 (une piperazine n,n#-disubstituee, inhibitrice de recapture de la dopamine)." Caen, 1992. http://www.theses.fr/1992CAEN2010.

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Ce travail a consiste a rechercher des voies de synthese rapide de molecules marquees au carbone-11 (t#1#/#2=20 min) ou au fluor-18 (t#1#/#2=110 min) pour l'etude in vivo de leurs biodistribution et pharmacocinetique par tomographie d'emission de positons. La preparation de la (#1#1c) fotemustine, une nitrosouree utilisee dans le traitement des tumeurs cerebrales, a ete mise au point en trois etapes a partir de l'iodomethane (#1#1c) et realisee en 70 min avec des rendements radiochimiques voisins de 30% (corriges de la decroissance). Cette synthese a ete automatisee afin d'obtenir des quantite
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González, Lira Christian Guillermo. "Estudio de Funcionalización de la (4-Nitro-Fenil)-1-Piperazina Orientada a la Síntesis de (4,7-Dimetoxi-Benzo[b]Tiofen-2-Carbonil) Piperazinil Arilbenzamidas como Potenciales Ligandos Serotoninérgicos." Tesis, Universidad de Chile, 2007. http://www.repositorio.uchile.cl/handle/2250/105666.

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Memoria para optar al título de Químico<br>Las arilpiperazinas constituyen una familia de compuestos de interés en el ámbito neurofarmacológico principalmente por sus acciones ansiolíticas y antidepresivas, a través de interacciones con el receptor serotoninérgico 5-HT1A. El presente trabajo de tesis informa de la síntesis de una serie de compuestos benzotiofenarilpiperazínicos 10 (a-f) adecuadamente funcionalizados. El acceso sintético a esta serie tiene lugar a través de una secuencia de 6 pasos a partir de 3,6-dimetoxi-2-nitrobenzaldehído con tioglicolato de metilo en medio básico. Como p
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Popova, Dina. "In vitro cellular models for neurotoxicity studies : neurons derived from P19 cells." Doctoral thesis, Umeå universitet, Institutionen för farmakologi och klinisk neurovetenskap, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133030.

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Humans are exposed to a variety of chemicals including environmental pollutants, cosmetics, food preservatives and drugs. Some of these substances might be harmful to the human body. Traditional toxicological and behavioural investigations performed in animal models are not suitable for the screening of a large number of compounds for potential toxic effects. There is a need for simple and robust in vitro cellular models that allow high-throughput toxicity testing of chemicals, as well as investigation of specific mechanisms of cytotoxicity. The overall aim of the thesis has been to evaluate n
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Macías, Victoria Elena Ramos. "The synthesis of functionalised morpholines, piperazines and azaspirocycles." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408568.

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FRANÇA, Maria Eduarda Rocha de. "Análises dos efeitos da dietilcarbamazina (DEC) sobre a fibrose hepática em camundongos C57BL/6J wild type." UNIVERSIDADE FEDERAL DE PERNAMBUCO, 2015. https://repositorio.ufpe.br/handle/123456789/15222.

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Aubry, Sylvain. "Nouvelle voie de synthèse de systèmes piperazines de type phthalascidine." Phd thesis, Université Claude Bernard - Lyon I, 2007. http://tel.archives-ouvertes.fr/tel-00179725.

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Nous nous sommes tout d'abord familiarisé à la synthèse de tétrahydroisoquinoléines incorporant des structures hétérocycliques. Cette méthode a été adaptée à la préparation d'intermédiaires synthétiques de type (1,3')-bis-tétrahydroisoquinoléines. Ces composés ont servi de plateforme à la synthèse des pipérazines polycycliques recherchées. Les propriétés biologiques de ces composés ont été étudiées par le biais d'une collaboration avec le « Centre for Molecular Drug Design » de l'Université de Salford (Grande-Bretagne) sous la supervision du Professeure Sylvie Ducki.<br />Pour la synthèse de d
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Conant, Alan Richard. "Nucleoside transport and inhibition by substituted piperazines in mammalian heart." Thesis, University of Kent, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359147.

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Anstiss, Mark Leslie. "Desymmetrisation of centrosymmetric piperazines : asymmetric total synthesis of dragmacidin alkaloids." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432294.

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Longue, Filho Mauro. "Síntese e avaliação da atividade nematicida de derivados da piperazina." Universidade Federal de Viçosa, 1998. http://www.locus.ufv.br/handle/123456789/8472.

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Submitted by Reginaldo Soares de Freitas (reginaldo.freitas@ufv.br) on 2016-09-05T16:30:56Z No. of bitstreams: 1 texto completo.pdf: 1163013 bytes, checksum: 9b6e165d1c8c35cdfc5b2abea3b1307d (MD5)<br>Made available in DSpace on 2016-09-05T16:30:56Z (GMT). No. of bitstreams: 1 texto completo.pdf: 1163013 bytes, checksum: 9b6e165d1c8c35cdfc5b2abea3b1307d (MD5) Previous issue date: 1998-08-19<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A busca de soluções para o controle de fitonematóides é um trabalho constante conduzido pela pesquisa química. No presente estudo foram
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41

McConnell, Brendan Neil. "Fragment-based approaches to targeting EthR from mycobacterium tuberculosis." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290255.

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Tuberculosis affects millions of people worldwide every year. The current treatment for TB is divided into a regimen of both first- and second-line drugs, where first-line treatments are more tolerated and require shorter treatment lengths. With rising levels of resistance, alternative treatment regimes are urgently needed to fight this disease. Ethionamide, a second-line drug is administered as a prodrug which is activated in vivo by the enzyme EthA, which is in turn regulated by EthR. The disruption of the action of EthR could lead to novel therapeutics which could enhance the efficacy of et
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42

Escada, Maria Suzel Costa de Sousa e. "Métodos de análise de piperazinas em fluidos biológicos." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/2994.

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Mestrado em Métodos Instrumentais e Controlo da Qualidade Analítica<br>Nas últimas décadas, é notório um acréscimo no consumo abusivo de drogas sintéticas nas sociedades contemporâneas. Estas adquirem uma expressão cada vez maior, na sociedade actual, graças à popularidade obtida como rave drugs e partypills. A partir da segunda metade dos anos 90, surgiram no mercado ilícito novas drogas de abuso sintéticas, em particular, as denominadas ‘‘piperazinas’’. Poderão distinguir-se, entre as drogas sintéticas derivadas das piperazinas: a 1-benzilpiperazina (BZP), 1-(3- trifluorometilfenil)piperazin
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43

MASHONDI, MOHAMED. "Synthese regiospecifique et regioselective d'aminosaccharides et de piperazino-saccharides a visee therapeutique." Amiens, 1996. http://www.theses.fr/1996AMIE0105.

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Ce travail decrit la synthese de deux familles d'aminosaccharides a visee therapeutique. La premiere gamme comprend des derives du d-galactose, du d-glucose, du d-xylose et du xylitol, sur lesquels ont ete greffes par l'intermediaire d'une jonction aminee, soit une chaine n-alkyle soit un groupement phenylalkyle. Trois methodes ont ete utilisees, sur le site anomerique ; condensation d'une amine primaire, sur les sites primaires : greffe du nh#3 ou de rnh#2 apres activation, sur les sites secondaires, d'abord preparation d'un aminosaccharide selon la sequence suivante, activation, azidation, r
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44

Firth, James D. "Lithiation/trapping of N-Boc piperazines and synthesis of the (–)-sparteine surrogate." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6880/.

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This thesis describes some novel aspects of the s-BuLi mediated lithiation/trapping of N-Boc heterocycles, including a systematic investigation into the lithiation/trapping of N-Boc piperazines. Chapter 2 details an in situ ReactIR™ investigation into the time required for both the lithiation and trapping events of some commonly used N-Boc heterocycles. The remarkable difference in the time taken for trapping with some electrophiles is of particular note. The information garnered in this investigation was used to direct the racemic and asymmetric lithiation of N-Boc piperazines, as described i
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45

Aitchison, Lara. "Exposure to benzylpiperazine (BZP) in adolescent rats : adulthood changes in anxiety-like behaviour : a thesis submitted in partial fulfilment of the requirements for the degree of Master of Science in Psychology /." 2006. http://library.canterbury.ac.nz/etd/adt-NZCU20060721.121511.

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46

Perry, James C. "Adulthood outcomes in rats following repeated adolescent exposure to 1-benzylpiperazine (BZP) and/or ethanol : a thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Psychology /." 2008. http://hdl.handle.net/10092/1610.

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47

Du, Yang active 21st century. "Thermodynamics of aqueous piperazine/aminoethylpiperazine for CO₂ capture." Thesis, 2014. http://hdl.handle.net/2152/25831.

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Aqueous piperazine (PZ) blended with N-(2-aminoethyl) piperazine (AEP) is an attractive solvent for CO₂ capture from coal-fired power plants. Blending PZ with AEP can remediate the precipitation issue of concentrated PZ while maintaining its high CO₂ absorption rate, and high resistance to degradation. 5 m PZ/2 m AEP also shows a milder nitrosamine issue than concentrated piperazine. A rigorous thermodynamic model was developed in Aspen Plus® to predict properties of PZ/AEP/H₂O/CO₂, using the electrolyte-Nonrandom Two-Liquid (eNRTL) activity coefficient model. A sequential regression was perfo
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48

Arbo, Marcelo Dutra. "In Vitro Toxicity Evaluation Of Piperazine Designer Drugs." Doctoral thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/78118.

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Arbo, Marcelo Dutra. "In Vitro Toxicity Evaluation Of Piperazine Designer Drugs." Tese, 2015. https://repositorio-aberto.up.pt/handle/10216/78118.

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50

Shey, Jing-Ying, and 徐錦英. "Soluble Polymer-Supported Combinatorial Synthesis Piperidine and Piperazine Derivatives." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/20405295067465780839.

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碩士<br>國立東華大學<br>化學研究所<br>87<br>Abstract Combinatorial synthesis of chemistry libraries is undergoing rapid examination as a tool to enhance drug research and development. While it appears obvious that combinatorial chemistry strategies offer the potential to enhance drug development by shortening the time to optimize a new lead by structure-activity relationship (SAR) studies, it is often less appreciated that the greatest value of combinatorial chemistry strategies lies in its potential to enhance discovery of novel leads or pharma- cophores. The development of both
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