Relevant bibliographies by topics / Piperazines

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Piperazines'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Piperazines"

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Kmoníček, Vojtěch, Martin Valchář, and Zdeněk Polívka. "Some 4-Substituted 1-(3-Pyridylmethyl)piperazines with Antihistamine Activity." Collection of Czechoslovak Chemical Communications 59, no. 10 (1994): 2343–50. http://dx.doi.org/10.1135/cccc19942343.

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Several compounds derived from nicotinic acid were prepared within a more extensive programme aiming at the synthesis of new substances with expected antihistamine and antidepressant activity. Some of these compounds display certain structural resemblance with the antidepressant agent piberaline (EGYT 475, Trelibet®, I) and its analogues. The products were used as intermediates for the synthesis of further compounds and most of them were subjected to pharmacological testing. Substituted nicotinic acid piperazides IIa - IId and IVa - IVe were obtained by reactions of nicotinoyl chloride (prepar
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Gettys, Kristen, Zhishi Ye, and Mingji Dai. "Recent Advances in Piperazine Synthesis." Synthesis 49, no. 12 (2017): 2589–604. http://dx.doi.org/10.1055/s-0036-1589491.

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Piperazine ranks as the third most common N-heterocycle appearing in small-molecule pharmaceuticals. This review highlights recent advances in methods development for the construction of the piperazine­ ring system with particular emphasis on preparing carbon-substituted piperazines.1 Introduction2 Reduction of (Di)ketopiperazine3 N-Alkylation4 Transition-Metal-Catalyzed/Mediated Piperazine Synthesis4.1 The SnAP and SLAP Methods4.2 Palladium-Catalyzed Cyclization4.3 Gold-Catalyzed Cyclization4.4 Other Metal-Catalyzed/Mediated Cyclization4.5 Borrowing Hydrogen Strategy4.6 Imine Reductive Cycliz
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Hafeez, Freeha, Ameer Fawad Zahoor, Azhar Rasul, et al. "Ultrasound-Assisted Synthesis and In Silico Modeling of Methanesulfonyl-Piperazine-Based Dithiocarbamates as Potential Anticancer, Thrombolytic, and Hemolytic Structural Motifs." Molecules 27, no. 15 (2022): 4776. http://dx.doi.org/10.3390/molecules27154776.

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Piperazine-based dithiocarbamates serve as important scaffolds for numerous pharmacologically active drugs. The current study investigates the design and synthesis of a series of dithiocarbamates with a piperazine unit as well as their biological activities. Under ultrasound conditions, the corresponding piperazine-1-carbodithioates 5a–5j were synthesized from monosubstituted piperazine 2 and N-phenylacetamides 4a–4j in the presence of sodium acetate and carbon disulfide in methanol. The structures of the newly synthesized piperazines were confirmed, and their anti-lung carcinoma effects were
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Little, Vanessa Renee, and Keith Vaughan. "Synthesis and characterization of several series of 4-acyl-1-[2-aryl-1-diazenyl]piperazines." Canadian Journal of Chemistry 92, no. 9 (2014): 838–48. http://dx.doi.org/10.1139/cjc-2014-0242.

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Five series of a novel class of 4-acyl-1-[2-aryl-1-diazenyl]piperazines have been synthesized and characterized: the 4-acetyl-1-[2-aryl-1-diazenyl]piperazines [series 1]; the 4-cyclohexylcarbonyl-1-[2-aryl-1-diazenyl]piperazines [series 2]; the 4-benzoyl-1-[2-aryl-1-diazenyl]piperazines [series 3]; the benzyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates [series 4]; and the t-butyl 4-[2-aryl-1-diazenyl]-1-piperazinecarboxylates [series 5]. The compounds were synthesized by diazotization of a primary aromatic amine and subsequent coupling to an appropriate secondary amine: 1-acetylpiperazine [
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Durand, Carolina, and Michal Szostak. "Recent Advances in the Synthesis of Piperazines: Focus on C–H Functionalization." Organics 2, no. 4 (2021): 337–47. http://dx.doi.org/10.3390/org2040018.

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Piperazine ranks as the third most common nitrogen heterocycle in drug discovery, and it is the key component of several blockbuster drugs, such as Imatinib (also marketed as Gleevec) or Sildenafil, sold as Viagra. Despite its wide use in medicinal chemistry, the structural diversity of piperazines is limited, with about 80% of piperazine-containing drugs containing substituents only at the nitrogen positions. Recently, major advances have been made in the C–H functionalization of the carbon atoms of the piperazine ring. Herein, we present an overview of the recent synthetic methods to afford
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Mosca, Alessio, Stefania Chiappini, Andrea Miuli, et al. "Piperazine Abuse and Psychosis: A Systematic Review of the Literature." Psychiatry International 5, no. 3 (2024): 552–63. http://dx.doi.org/10.3390/psychiatryint5030040.

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Background: Piperazines, synthetic compounds known for their stimulant and hallucinogenic effects, have gained prominence among novel psychoactive substances (NPS) and are frequently associated with adverse psychiatric outcomes, including psychosis. Methods: A systematic review of the literature available up to 23 May 2024 was conducted, using the PubMed, Scopus, and Web of Science databases, in addition to the related gray literature, utilizing the following search strategy: “piperazines” AND (“psychosis” OR “hallucination” OR “delusion” OR “schizophrenia” OR “delusional” OR “schizoaffective”
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Magriotis, Plato A. "Recent progress toward the asymmetric synthesis of carbon-substituted piperazine pharmacophores and oxidative related heterocycles." RSC Medicinal Chemistry 11, no. 7 (2020): 745–59. http://dx.doi.org/10.1039/d0md00053a.

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The piperazine drugs are mostly N-substituted compared to only a few C-substituted drugs. To explore this unknown chemical space, asymmetric syntheses of C-substituted piperazines is the subject of this review.
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Verma, Arvind Kumar, Arun Kumar, and Kunwar Abhishek Singh. "Synthesis and molecular docking for anticonvulsant activity of some new benzoxazole derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 35, no. 02 (2025): 551. https://doi.org/10.59467/ijhc.2025.35.551.

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To explore the anticonvulsant action related to the benzoxazole framework, a series of benzoxazole-piperazine derivatives, namely N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-(piperazin-1-yl) acetamides (3a-e) (3), was synthesized by reacting N-(4-(benzo[d]oxazol-2-yl)phenyl)-2-chloroacetamide (2) with various substituted piperazines. Molecular docking studies were conducted using Auto Dock Vina 1.5.7 to evaluate the compounds' binding affinities with anticonvulsant-related targets protein data bank ID: 3PO7, 7WLJ, using zonisamide as a standard drug to ensure their potential. Several compounds exhibit
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Penjisevic, Jelena, Vladimir Sukalovic, Deana Andric, et al. "Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines." Journal of the Serbian Chemical Society 81, no. 4 (2016): 347–56. http://dx.doi.org/10.2298/jsc151021097p.

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A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine. Biological evaluation of the synthesized compounds was pointed out for seven compounds, of which 1-(2-methoxyphenyl)-4-{[1-(2-nitrobenzyl)piperidin-4-yl]methyl}piperazine had the highest affinity for the dopamine D2 receptor. For all seven selected compounds docking analysis was performed in order to establish their structure-to-activity relationship.
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Kafka, Stanislav, Jan Čermák, Tomáš Novák, František Pudil, Ivan Víden, and Miloslav Ferles. "Syntheses of piperazines substituted on the nitrogen atoms with allyl, propyl, 2-hydroxypropyl and 3-hydroxypropyl groups." Collection of Czechoslovak Chemical Communications 50, no. 5 (1985): 1201–11. http://dx.doi.org/10.1135/cccc19851201.

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The paper describes synthesis of 1,4-diallylpiperazine (I), 1-allylpiperazine (III), 1-propylpiperazine (IV), 1-(1-piperazinyl)-2-propanol (V), 3-(1-piperazinyl)-1-propanol (VI), 1-allyl-4-propylpiperazine (VII), 1-(4-allyl-1-piperazinyl)-2-propanol (VIII), 3-(4-allyl-1-piperazinyl)-1-propanol (IX), 1,4-dipropylpiperazine (X), 1-(4-propyl-1-piperazinyl)-2-propanol (XI), 3-(4-propyl-1-piperazinyl)-1-propanol (XII), 1,4-bis(2-hydroxypropyl)piperazine (XIII), 3-[4-(2-hydroxypropyl)-1-piperazinyl]-1-propanol (XIV) and 1,4-bis(3-hydroxypropyl)piperazine (XV). Retention indices of I-XV reported and
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Dissertations / Theses on the topic "Piperazines"

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Macías, Victoria Elena Ramos. "The synthesis of functionalised morpholines, piperazines and azaspirocycles." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408568.

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Aubry, Sylvain. "Nouvelle voie de synthèse de systèmes piperazines de type phthalascidine." Phd thesis, Université Claude Bernard - Lyon I, 2007. http://tel.archives-ouvertes.fr/tel-00179725.

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Nous nous sommes tout d'abord familiarisé à la synthèse de tétrahydroisoquinoléines incorporant des structures hétérocycliques. Cette méthode a été adaptée à la préparation d'intermédiaires synthétiques de type (1,3')-bis-tétrahydroisoquinoléines. Ces composés ont servi de plateforme à la synthèse des pipérazines polycycliques recherchées. Les propriétés biologiques de ces composés ont été étudiées par le biais d'une collaboration avec le « Centre for Molecular Drug Design » de l'Université de Salford (Grande-Bretagne) sous la supervision du Professeure Sylvie Ducki.<br />Pour la synthèse de d
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Conant, Alan Richard. "Nucleoside transport and inhibition by substituted piperazines in mammalian heart." Thesis, University of Kent, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359147.

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Anstiss, Mark Leslie. "Desymmetrisation of centrosymmetric piperazines : asymmetric total synthesis of dragmacidin alkaloids." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432294.

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Firth, James D. "Lithiation/trapping of N-Boc piperazines and synthesis of the (–)-sparteine surrogate." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6880/.

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This thesis describes some novel aspects of the s-BuLi mediated lithiation/trapping of N-Boc heterocycles, including a systematic investigation into the lithiation/trapping of N-Boc piperazines. Chapter 2 details an in situ ReactIR™ investigation into the time required for both the lithiation and trapping events of some commonly used N-Boc heterocycles. The remarkable difference in the time taken for trapping with some electrophiles is of particular note. The information garnered in this investigation was used to direct the racemic and asymmetric lithiation of N-Boc piperazines, as described i
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SEFRAOUI, EL HOURINE. "Synthese et etude biologique de derives butyriques dans la serie des piperazines." Amiens, 1992. http://www.theses.fr/1992AMIEP047.

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Zajdel, Pawel. "Novel Aryl-alkyl-piperazines with N-acylated amino acids as serotoninergic receptors ligands." Montpellier 1, 2006. http://www.theses.fr/2006MON13511.

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Ce travail présente des nouveaux composés ciblant les récepteurs sérotoninergiques. La première partie traite de la synthèse supposée d'une chimiothèque d'arylpiperazines. Plusieurs composés montrent une haute affinité pour 5-HT1A(K1=3-52nM). Des tests pharmacologiques pré-cliniques ont révélé des comportements de type agoniste complet ou partiel de 5-HT1A ou antagoniste 5-HT1A/5-HT2A. La synthèse supportée de 64 dérivés sulfonamide de la proline carboxamide est décrite, visant l'obtention d'antagonistes de 5-HT7. La dernière partie traite de la synthèse supportée sur lanternes BAL de dérivés
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Andersson, Hans. "Reaction between grignard reagents and heterocyclic N-oxides synthesis of substituted pyridines, piperidines and piperazines /." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25619.

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Pradet, Charlotte. "Studies towards the synthesis and mode of action of epidithio-3, 6-diketo-2, 5-piperazines." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409015.

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Dunn, Rachael E. B. "Flexible access to an array of optically-enriched conformationally-locked bicyclic morpholines and approaching bridged bicyclic piperazines." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24533.

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Over recent years, bridged heterocycles have emerged as desirable targets within the pharmaceutical industry. More specifically, pharmaceutical partners have become interested in exploring the bioactivity of bridged morpholines, as well as bridged piperazines. Despite the interest in these types of compounds, there is a lack of routes into these scaffolds which allow for diversification surrounding the core scaffold. Consequently, the focus of this study was to develop preparative access into these synthetically challenging, strained bicyclic 6,5-systems. The aim was for the developed routes t
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Books on the topic "Piperazines"

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1935-, Gingell Clive, ed. Management of ED: Focus on sildenafil : a urologist's approach. PharmaLibri, 1998.

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J, Fowler Clare, ed. Management of ED: Focus on sildenafil : a neurologist's approach. PharmaLibri, 1999.

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Botz-Bornstein, Thorsten. The philosophy of Viagra: Bioethical responses to the viagrification of the modern world. Rodopi, 2011.

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Kagaku Busshitsu Hyōka Kenkyū Kikō and Shin Enerugī Sangyō Gijutsu Sōgō Kaihatsu Kikō (Japan), eds. Piperajin: Piperazine. Seihin Hyōka Gijutsu Kiban Kikō Kagaku Busshitsu Hyōka Kenkyū Kikō, 2007.

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Attorney-General, New Zealand. Report of the Attorney-General under the New Zealand Bill of Rights Act 1990 on the Misuse of Drugs (Classification of BZP) Amendment Bill 2007. House of Representatives, 2007.

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Great Britain. Health and Safety Executive. Occupational Medicine and Hygiene Laboratory. Organic isocyanates in air: Laboratory method using 1-(2-methoxyphenyl) piperazine solution and high performance liquid chromatography. HSE Books, 1994.

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Occupational Medicine and Hygiene Laboratory. Organic isocyanates in air: Laboratory method using 1-(2-methoxyphenyl) piperazine solution and high performance liquid chromatography. Health and Safety Executive, 1987.

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Sedefov, Roumen. Report on the risk assessment of BZP in the framework of the Council decision on new psychoactive substances. Office for Official Publications of the European Communities, 2009.

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Bain, Joseph Paul 1914. Derivatives of Piperazine VIII: Synthesis of Substituted Piperazines and Reactions of Piperazines with Conjugated Systems. Creative Media Partners, LLC, 2021.

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Dunzendorfer, Udo. Sildenafil (Milestones in Drug Therapy). Birkhäuser Basel, 2005.

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Book chapters on the topic "Piperazines"

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Stark, Margaret, Jason Payne-James, and Michael Scott-Ham. "Piperazines." In Symptoms and Signs of Substance Use, 4th ed. Routledge, 2025. https://doi.org/10.4324/9781003381730-29.

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Kuleya, Chipo, and Michael D. Cole. "Forensic Analysis of Piperazines." In Chromatographic Techniques in the Forensic Analysis of Designer Drugs. CRC Press, 2018. http://dx.doi.org/10.1201/9781315313177-17.

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Towler, Steven, and Marta Concheiro. "Target Analysis of Phenethylamines, Tryptamines, and Piperazines in Blood and Urine." In Methods in Pharmacology and Toxicology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2605-4_3.

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de Groot, Anton C. "Piperazine." In Monographs In Contact Allergy. CRC Press, 2022. http://dx.doi.org/10.1201/9781003158004-391.

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Hirota, E., K. Kuchitsu, T. Steimle, J. Vogt, and N. Vogt. "116 C4H10N2 Piperazine." In Molecules Containing Three or Four Carbon Atoms and Molecules Containing Five or More Carbon Atoms. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-41504-3_117.

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Alicante, Raquel. "Piperazine Azopolymer Thin Films." In Springer Theses. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-31756-9_4.

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Laux, Gerd. "Piperazine Phenothiazines: Fluphenazine and Perphenazine." In NeuroPsychopharmacotherapy. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-62059-2_474.

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Eller, Sarah, and Marcelo Dutra Arbo. "Piperazine Designer Drugs of Abuse." In Handbook of Substance Misuse and Addictions. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92392-1_166.

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Laux, Gerd. "Piperazine Phenothiazines: Fluphenazine and Perphenazine." In NeuroPsychopharmacotherapy. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-56015-1_474-1.

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Eller, Sarah, and Marcelo Dutra Arbo. "Piperazine Designer Drugs of Abuse." In Handbook of Substance Misuse and Addictions. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67928-6_166-1.

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Conference papers on the topic "Piperazines"

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Akkor, Ilayda, Shachit S. Iyer, John Dowdle, Le Wang, and Chrysanthos Gounaris. "Economic Optimization and Impact of Utility Costs on the Optimal Design of Piperazine-Based Carbon Capture." In Foundations of Computer-Aided Process Design. PSE Press, 2024. http://dx.doi.org/10.69997/sct.147100.

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Recent advances in process design for solvent-based, post-combustion capture (PCC) processes, such as the Piperazine/Advanced Flash Stripper (PZ/AFS) process, have led to a reduction in the energy required for capture. Even though PCC processes are progressively improving in Technology Readiness Levels (TRL), with a few commercial installations, incorporating carbon capture adds cost to any operation. Hence, cost reduction will be instrumental for proliferation. The aim of this work is to improve process economics through optimization and to identify the parameters in our economic model that h
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Huang, Shengyuan, Olajide Otitoju, Yao Zhang, and Meihong Wang. "Technical Assessment of direct air capture using piperazine in an advanced solvent-based absorption process." In The 35th European Symposium on Computer Aided Process Engineering. PSE Press, 2025. https://doi.org/10.69997/sct.124483.

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Climate and environmental problems caused by increasing CO2 concentration in the atmosphere make the direct air capture (DAC) technology having great prospects for development. As the widely used solvent in carbon capture based on chemical absorption processes, MEA still fails to address the issues of high energy consumption and high costs when used in DAC process. In this study, piperazine (PZ) was used as the new solvent for DAC process. The new configuration was simulated in Aspen Plus� V11 and the model was validated through experimental data and model comparison. It is followed by investi
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Peng, Lei, Qiang Fu, Zhi Li, Musong Lin, Yaohong Zhao, and Zaikun Wu. "Investigate of mass transfer of CO2 absorption into the mixed solution of piperazine and diethanolamine in a packed column." In Fifth International Conference on Green Energy, Environment, and Sustainable Development, edited by Mohammadreza Aghaei, Hongyu Ren, and Xiaoshuan Zhang. SPIE, 2024. http://dx.doi.org/10.1117/12.3044925.

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Sevcik, Richard, Dana Němečková, Eva Havránková, Jan Šimbera, and Pavel Pazdera. "Sophisticated synthesis of monosubstituted piperazines – from a batch reaction vessel to a flow (microwave) reactor." In The 23rd International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2019. http://dx.doi.org/10.3390/ecsoc-23-06478.

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Usha, R., M. Magesh, N. Kanagathara, V. Natarajan, and R. Gowri Shankar Rao. "Investigation of temperature dependent paramagnetic magnetic behavior of adducts of divalent metal chlorides with substituted piperazines using SQUID." In Special Issue of the 4th International Symposium on Advanced Materials and Nanotechnology (iSAMN 2020). AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0082521.

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Pazdera, P., B. Andělová, and D. Němečková. "Utilization of piperazine for interphase catalytic systems." In The 13th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00192.

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Loupias, Pauline, Alexandra Dassonville-Klimpt, Elodie Lohou, Nicolas Taudon, and Pascal Sonnet. "Trojan horse strategy: synthesis of piperazine-based siderophores." In 4th International Electronic Conference on Medicinal Chemistry. MDPI, 2018. http://dx.doi.org/10.3390/ecmc-4-05579.

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Zhang, Xiaoguang, Xuexing Chen, Qingchun Chen, et al. "Preparation and Co (II) Removal of ZnO/Poly-Piperazineamide Nanofiltration Membranes." In 2017 25th International Conference on Nuclear Engineering. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/icone25-67740.

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A series of nanofiltration membranes were prepared by interfacial polymerization of piperazine and terephthaloyl chloride on the surface of polyacrylonitrile (PAN) ultrafiltration membranes. ZnO nanoparticles were incorporated in the active separation layer to modify the performances of the membranes. The preparation conditions as the monomer concentration, dosage of nano-ZnO particles and the reaction time on removal of a simulated radioactive nuclide Co (II) were investigated. Fourier transform infrared in attenuated total reflection mode verified the formation of polyamide on the PAN ultraf
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Lee, Young Bok, Gina Chun, Deog J. Kim, et al. "Abstract 1371: Antitumor activity of a new quinoxalinyl-piperazine compound." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1371.

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Huff, D. W., and P. Murphy. "350. Piperazine: Development and Validation of an Air Monitoring Method." In AIHce 1998. AIHA, 1999. http://dx.doi.org/10.3320/1.2762752.

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Reports on the topic "Piperazines"

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Rochelle, Gary, Fred Closmann, Jorge Martorell, et al. Front-End Engineering Design for Piperazine with the Advanced Stripper. Office of Scientific and Technical Information (OSTI), 2022. http://dx.doi.org/10.2172/1878608.

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John T. Cullinane. THERMODYNAMICS AND KINETICS OF AQUEOUS PIPERAZINE WITH POTASSIUM CARBONATE FOR CARBON DIOXIDE ABSORPTION. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/839556.

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Marcus Hilliard. THERMODYNAMICS OF AQUEOUS PIPERAZINE/POTASSIUM CARBONATE/CARBON DIOXIDE CHARACTERIZED BY THE ELECTROLYTE NRTL MODEL WITHIN ASPEN PLUS. Office of Scientific and Technical Information (OSTI), 2005. http://dx.doi.org/10.2172/838130.

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Chen, Eric, Steven Fulk, Matt Beaudry, et al. Evaluation of Concentrated Piperazine for CO2 Capture from Coal-Fired Flue Gas (Final Report, REV0). Office of Scientific and Technical Information (OSTI), 2019. http://dx.doi.org/10.2172/1512446.

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