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Dissertations / Theses on the topic 'Piperazines'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

MaciÌas, Victoria Elena Ramos. "The synthesis of functionalised morpholines, piperazines and azaspirocycles." Thesis, University of Liverpool, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408568.

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2

Aubry, Sylvain. "Nouvelle voie de synthèse de systèmes piperazines de type phthalascidine." Phd thesis, Université Claude Bernard - Lyon I, 2007. http://tel.archives-ouvertes.fr/tel-00179725.

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Nous nous sommes tout d'abord familiarisé à la synthèse de tétrahydroisoquinoléines incorporant des structures hétérocycliques. Cette méthode a été adaptée à la préparation d'intermédiaires synthétiques de type (1,3')-bis-tétrahydroisoquinoléines. Ces composés ont servi de plateforme à la synthèse des pipérazines polycycliques recherchées. Les propriétés biologiques de ces composés ont été étudiées par le biais d'une collaboration avec le « Centre for Molecular Drug Design » de l'Université de Salford (Grande-Bretagne) sous la supervision du Professeure Sylvie Ducki.<br />Pour la synthèse de d

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3

Conant, Alan Richard. "Nucleoside transport and inhibition by substituted piperazines in mammalian heart." Thesis, University of Kent, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359147.

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4

Anstiss, Mark Leslie. "Desymmetrisation of centrosymmetric piperazines : asymmetric total synthesis of dragmacidin alkaloids." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432294.

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5

Firth, James D. "Lithiation/trapping of N-Boc piperazines and synthesis of the (–)-sparteine surrogate." Thesis, University of York, 2014. http://etheses.whiterose.ac.uk/6880/.

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This thesis describes some novel aspects of the s-BuLi mediated lithiation/trapping of N-Boc heterocycles, including a systematic investigation into the lithiation/trapping of N-Boc piperazines. Chapter 2 details an in situ ReactIR™ investigation into the time required for both the lithiation and trapping events of some commonly used N-Boc heterocycles. The remarkable difference in the time taken for trapping with some electrophiles is of particular note. The information garnered in this investigation was used to direct the racemic and asymmetric lithiation of N-Boc piperazines, as described i

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6

SEFRAOUI, EL HOURINE. "Synthese et etude biologique de derives butyriques dans la serie des piperazines." Amiens, 1992. http://www.theses.fr/1992AMIEP047.

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7

Zajdel, Pawel. "Novel Aryl-alkyl-piperazines with N-acylated amino acids as serotoninergic receptors ligands." Montpellier 1, 2006. http://www.theses.fr/2006MON13511.

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Ce travail présente des nouveaux composés ciblant les récepteurs sérotoninergiques. La première partie traite de la synthèse supposée d'une chimiothèque d'arylpiperazines. Plusieurs composés montrent une haute affinité pour 5-HT1A(K1=3-52nM). Des tests pharmacologiques pré-cliniques ont révélé des comportements de type agoniste complet ou partiel de 5-HT1A ou antagoniste 5-HT1A/5-HT2A. La synthèse supportée de 64 dérivés sulfonamide de la proline carboxamide est décrite, visant l'obtention d'antagonistes de 5-HT7. La dernière partie traite de la synthèse supportée sur lanternes BAL de dérivés

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8

Andersson, Hans. "Reaction between grignard reagents and heterocyclic N-oxides synthesis of substituted pyridines, piperidines and piperazines /." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25619.

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9

Pradet, Charlotte. "Studies towards the synthesis and mode of action of epidithio-3, 6-diketo-2, 5-piperazines." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409015.

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10

Dunn, Rachael E. B. "Flexible access to an array of optically-enriched conformationally-locked bicyclic morpholines and approaching bridged bicyclic piperazines." Thesis, University of Strathclyde, 2014. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24533.

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Over recent years, bridged heterocycles have emerged as desirable targets within the pharmaceutical industry. More specifically, pharmaceutical partners have become interested in exploring the bioactivity of bridged morpholines, as well as bridged piperazines. Despite the interest in these types of compounds, there is a lack of routes into these scaffolds which allow for diversification surrounding the core scaffold. Consequently, the focus of this study was to develop preparative access into these synthetically challenging, strained bicyclic 6,5-systems. The aim was for the developed routes t

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11

Rudner-Varga, Vanda. "Exploring the structure activity relationships of halogen containing N-(pyridin-3-yl)- piperazines and homopiperazines at α4β2 nAChRs". Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15869.

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Introduction: The α4β2 subtype of the nicotinic acetylcholine receptor (nAChR) has been pursued as a drug target for treatment of psychiatric and neurodegenerative disorders and smoking cessation aids for decades. Particular halogen containing compounds have showed promising results at α4β2 subtype of nAChR. Aims: To explore and understand the structure activity relationships of halogen containing α4β2 agonists. Potentially, this could lead to rational design of superagonists. Methods: Consecutive series of halogen containing compounds were investigated by using two-electrode voltage-clamp e

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12

Kuleya, Chipo. "The synthesis, analysis and characterisation of piperazine based drugs." Thesis, Anglia Ruskin University, 2014. https://arro.anglia.ac.uk/id/eprint/579889/1/Thesis%20%20final%20-%20Chipo%20Kuleya%20July%202015.pdf.

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This study developed a GC-MS method for the simultaneous detection of piperazines and congeners in street samples of amphetamine type stimulants. This research investigated the clandestine routes of synthesis and chemical profiles of phenylpiperazines, represented by 1- (4-fluorophenyl)piperazine (4-FPP) and 1-(3-trifluoromethylphenyl)piperazine (3-TFMPP). These drugs are part of the increasingly prevalent illicit new psychoactive substances. The presence of (2, 3, 4) FPP and (2, 3, 4) TFMPP positional isomers has been identified by other researchers as a limitation due to their similar

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13

Kuleya, Chipo. "The synthesis, analysis and characterisation of piperazine based drugs." Thesis, Anglia Ruskin University, 2014. http://arro.anglia.ac.uk/579889/.

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This study developed a GC-MS method for the simultaneous detection of piperazines and congeners in street samples of amphetamine type stimulants. This research investigated the clandestine routes of synthesis and chemical profiles of phenylpiperazines, represented by 1- (4-fluorophenyl)piperazine (4-FPP) and 1-(3-trifluoromethylphenyl)piperazine (3-TFMPP). These drugs are part of the increasingly prevalent illicit new psychoactive substances. The presence of (2, 3, 4) FPP and (2, 3, 4) TFMPP positional isomers has been identified by other researchers as a limitation due to their similar chemic

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14

Moreno, Ivo Emanuel Dias. "Determinação de novas drogas de abuso com recurso à microextracção em seringa empacotada." Master's thesis, Universidade da Beira Interior, 2011. http://hdl.handle.net/10400.6/2073.

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As piperazinas são consideradas um novo grupo de drogas de abuso sintéticas que surgiram no mercado ilícito a partir da segunda metade dos anos 90. Os seus efeitos psicoactivos, como por exemplo estados de euforia, são comparáveis aos obtidos por consumo de anfetaminas e ecstasy, sendo por isso consideradas uma alternativa legal, barata e segura. Deste modo torna-se necessário o desenvolvimento de métodos analíticos rápidos e sensíveis para a quantificação e determinação destas drogas em amostras biológicas. O objectivo deste trabalho foi o desenvolvimento e validação de um método analítico

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15

Topper, Melissa Elizabeth. "Design, Combinatorial Synthesis, and Biological Evaluation of Novel α-Helical Mimetics Based on Functionalized Piperazines as Antagonists of p53/MDM2 Interactions". Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3454.

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The p53 protein promotes tumor eradication upon activation, making it an attractive target in cancer therapies. A reported 50% of all human cancers display aberrant activation of the MDM2 oncoprotein, which directly promotes tumorgenesis by inactivating the transcriptional activity of wild type p53, and is commonly associated with drug, chemo, and radio therapy resistance. Previously reported crystallographic analysis of the p53/MDM2 complex infers that the p53 protein forms a 2.5 turn amphipathic alpha helix whose hydrophobic face interacts within a deep hydrophobic cleft in the NH2-terminal

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16

Moura, Rebeca Garcia. "Síntese de um fragmento precursor do Indinavir." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-11042017-075910/.

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Considerando-se a necessidade brasileira de se obterem fármacos a preços competitivos e usando tecnologia nacional, visamos sintetizar um fragmento do Indinavir empregando como material de partida a L-serina, um aminoácido natural de baixo custo. Desta maneira, desenvolvemos a seguinte rota, em 6 etapas: p-tosilação da serina, pelo uso de cloreto de p-tosila / NaOH; amidação da p-tosilserina, empregando-se o sal de terc-butilamônio da N-hidroxissuccinimida / DCC; ciclização da (S)-2-terc-butil-N-p-tosilserina, em condição de transferência de fase, com cloreto de p-tosila / carbonato de potássi

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17

Khan, Abdul Majeed 1980. "Síntese e termoquímica de adutos de brometos de metais bivalentes com aminas hetrocíclicas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249123.

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Orientador: Pedro Oliver Dunstan Lozano<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T07:28:40Z (GMT). No. of bitstreams: 1 Khan_AbdulMajeed_D.pdf: 3004508 bytes, checksum: 1d8c778094bf0cb1b93fa7bf80e19074 (MD5) Previous issue date: 2013<br>Resumo: Os adutos MX2.nL (M = Mn, Fe, Co, Ni, Cu ou Zn, L = 3-cianopiridina, piperidina ou piperazaina, X = Br, n = 0,5, 0,75, 1, 1,5, 2 ou 4), foram sintetizados e caracterizados através de análise elementar, determinação de pontos de fusão, espectroscopia IV e eletrônica e análise

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18

Silva, Daiany Priscilla Bueno da. "Atividade anti-inflamatória e antinociceptiva de 4-((1-fenil-1h-pirazol-4-il) metil) piperazina-1-carboxilato: um novo derivado piperazínico." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5497.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-20T13:30:13Z No. of bitstreams: 2 Dissertação - Daiany Priscilla Bueno da Silva - 2015.pdf: 1122736 bytes, checksum: fc98524b1ad5d0e3a0cb2e1cc87bc933 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-04-20T13:32:30Z (GMT) No. of bitstreams: 2 Dissertação - Daiany Priscilla Bueno da Silva - 2015.pdf: 1122736 bytes, checksum: fc98524b1ad5d0e3a0cb2e1cc87bc933 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a771

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19

Viana, Fernando AndrÃ Campos. "Estudo comparativo, randomizado para avaliar a eficÃcia terapÃutica da piperazina hexahidratada com extrato fluido de rhamnus purshiana no tratamento da ascaridÃase." Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=646.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A eficÃcia e a seguranÃa terapÃutica de um medicamento a base de piperazina hexahidratada associada com o extrato fluido de Rhamnus purshiana (DM IndÃstria FarmacÃutica) usada como tratamento anti-helmÃntico em pacientes no CearÃ, Brasil, foi testado em comparaÃÃo com o produto composto de piperazina sem qualquer associaÃÃo (DM IndÃstria FarmacÃutica). Um estudo prospectivo, randomizado, controlado e duplo cego, comparando taxas de cura para infecÃÃo por Ascaris lunbricoides. Amostras coprolÃgicas de 990 pacientes foram coletadas

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20

Vasconcelos, Leonardo de. "Síntese de um fragmento precursor do fármaco Indinavir." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-23042013-141617/.

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Neste trabalho foram aprofundados nossos estudos para obtenção da (S)-2-terc-butilamida-4-(3-picolil)piperazina, pela abertura da (S)-2-terc-butilcarboxamida-N-p-tosilaziridina seguida de ciclização, em 78% de rendimento, com o triflato de vinildifenilsulfônio. A aziridina foi preparada por um processo de ciclização, em condições de transferência de fase, partindo-se da L-serina, um aminoácido natural de baixo custo. Esta rota sintética rendeu um material que apresenta a mesma estereoquímica S do fragmento piperazínico usado na síntese do Indinavir, podendo vir a constituir uma via alternativa

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21

González, Lira Christian Guillermo. "Estudio de Funcionalización de la (4-Nitro-Fenil)-1-Piperazina Orientada a la Síntesis de (4,7-Dimetoxi-Benzo[b]Tiofen-2-Carbonil) Piperazinil Arilbenzamidas como Potenciales Ligandos Serotoninérgicos." Tesis, Universidad de Chile, 2007. http://www.repositorio.uchile.cl/handle/2250/105666.

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Memoria para optar al título de Químico<br>Las arilpiperazinas constituyen una familia de compuestos de interés en el ámbito neurofarmacológico principalmente por sus acciones ansiolíticas y antidepresivas, a través de interacciones con el receptor serotoninérgico 5-HT1A. El presente trabajo de tesis informa de la síntesis de una serie de compuestos benzotiofenarilpiperazínicos 10 (a-f) adecuadamente funcionalizados. El acceso sintético a esta serie tiene lugar a través de una secuencia de 6 pasos a partir de 3,6-dimetoxi-2-nitrobenzaldehído con tioglicolato de metilo en medio básico. Como p

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22

Escada, Maria Suzel Costa de Sousa e. "Métodos de análise de piperazinas em fluidos biológicos." Master's thesis, Universidade de Aveiro, 2007. http://hdl.handle.net/10773/2994.

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Mestrado em Métodos Instrumentais e Controlo da Qualidade Analítica<br>Nas últimas décadas, é notório um acréscimo no consumo abusivo de drogas sintéticas nas sociedades contemporâneas. Estas adquirem uma expressão cada vez maior, na sociedade actual, graças à popularidade obtida como rave drugs e partypills. A partir da segunda metade dos anos 90, surgiram no mercado ilícito novas drogas de abuso sintéticas, em particular, as denominadas ‘‘piperazinas’’. Poderão distinguir-se, entre as drogas sintéticas derivadas das piperazinas: a 1-benzilpiperazina (BZP), 1-(3- trifluorometilfenil)piperazin

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23

Monaghan, S. M. "Synthetic studies in the piperazine-2,5-dione area." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47304.

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24

Uddin, Farid. "Use of piperazine ligands for bleaching and epoxidation catalysis." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/692.

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Following reports that the dinuclear manganese complex of the ligand 1, 4, 7-trimethyl-1, 4, 7-triazacyclononane (TMTACN) was a potent bleaching catalyst, its catalytic oxidative activity was thoroughly studied. Apart from its catalytic bleaching activity, it has shown to be a versatile catalyst in terms of its substrate scope. In bleaching, it still remains the benchmark with regards to its catalytic bleaching activity against which systems in development are compared. Chapter one discusses the need for a bleaching catalyst in detergent formulations and the advantages it offers over existing

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25

Bishnoi, Sanjay. "Carbon dioxide absorption and solution equilibrium in piperazine activated methyldiethanolamine /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p3004215.

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26

Safko, Jason P. "Luminescent Nitrogen and Sulfure Adducts of CuI Disubstituted Piperazine Complexes." W&M ScholarWorks, 2012. https://scholarworks.wm.edu/etd/1539626933.

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27

Tavet, Fabrice. "Nouveaux derives de la piperazine : synthese, relation structure-activite, proprietes pharmacologiques." Paris 5, 1991. http://www.theses.fr/1991PA05P617.

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28

Jakobsson, Josef. "Molecular mechanisms underlying platelet inhibition obtained by novel piperazine-purine analogues." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93312.

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Introduction. MK-substances are a new class of piperazine-purine analogues bearing nitrate esters with confirmed cardioprotective, anti-inflammatory and antithrombotic effects. The length of the carbon side chain (spacer) connecting the nitrate ester to the basic molecular structure seems to be of importance for the platelet inhibitory effect but the molecular mechanisms underlying this are not yet fully understood. Aim. Establish molecular evidence explaining the observed differences in platelet inhibition obtained by a new group of piperazine-purine analogues with different spacer length. Me

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29

Lamouri, AAzdine. "Antagonistes du paf derives de la piperazine synthese, pharmaco-toxicologie et structure-activite." Paris 7, 1990. http://www.theses.fr/1990PA077205.

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Le platelet activating factor (paf) est un ether-phospholipide implique dans de nombreux phenomenes physiopathologiques tels que l'inflammation et l'allergie. A partir de l'etude des cartes de potentiels electrostatiques a 3d d'antagonistes connus de cet autocoide, une premiere hypothese sur les fonctionnalites du recepteur a ete faite. Ce modele nous a permis de preparer une nouvelle classe d'antagonistes: les n,n-bis-trimethoxy-3,4,5-benzoyl piperazines substituees en position 2. En termes d'agregation plaquettaire comme de binding, nous avons obtenu des molecules antagonistes, dont les acti

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Intagliata, Sebastiano. "New alkylpiperazines as 5-HT7R ligands." Doctoral thesis, Università di Catania, 2016. http://hdl.handle.net/10761/3918.

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The 5-HT7 receptor is the last member of the serotonin receptors family. This receptor, cloned and identified in 1993, belongs to the G protein-coupled receptor family and is positively coupled with adenylyl cyclase. Different isoforms, which differ only in the length and amino acid composition of their C-terminal tail, are generated by alternative splicing of the 5-HT7 receptor gene and are namely: 5-HT7(a), (b), (c) in rat and 5-HT7(a), (b), (d) in human. These isoforms do not show significant differences in their pharmacological profile, signal transduction or tissue distribution a

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FRANÇA, Maria Eduarda Rocha de. "Análises dos efeitos da dietilcarbamazina (DEC) sobre a fibrose hepática em camundongos C57BL/6J wild type." UNIVERSIDADE FEDERAL DE PERNAMBUCO, 2015. https://repositorio.ufpe.br/handle/123456789/15222.

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Longue, Filho Mauro. "Síntese e avaliação da atividade nematicida de derivados da piperazina." Universidade Federal de Viçosa, 1998. http://www.locus.ufv.br/handle/123456789/8472.

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Submitted by Reginaldo Soares de Freitas (reginaldo.freitas@ufv.br) on 2016-09-05T16:30:56Z No. of bitstreams: 1 texto completo.pdf: 1163013 bytes, checksum: 9b6e165d1c8c35cdfc5b2abea3b1307d (MD5)<br>Made available in DSpace on 2016-09-05T16:30:56Z (GMT). No. of bitstreams: 1 texto completo.pdf: 1163013 bytes, checksum: 9b6e165d1c8c35cdfc5b2abea3b1307d (MD5) Previous issue date: 1998-08-19<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>A busca de soluções para o controle de fitonematóides é um trabalho constante conduzido pela pesquisa química. No presente estudo foram

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Walker, Roderick Bryan. "HPLC analysis and pharmacokinetics of cyclizine." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1003279.

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The investigations detailed in this dissertation have been conducted to address the paucity of pharmacokinetic information, in published literature, pertaining to cyclizine. The areas of investigation have included the selective quantitation of both cyclizine and its demethylated metabolite, norcyclizine in serum and urine, assessment of stability of both compounds in stored biological samples, dosage form analysis, dissolution rate testing of tablets, and bioavailability and pharmacokinetics following administration of an intravenous solution, and tablets to humans. High-performance liquid ch

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Maignan, Jordany Richarlson. "Development of Orally Bioavailable 4(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones with Potent Anti-malarial Activity." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5873.

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Although Malaria rates are on the decline due to the efforts of the World Health Organization and other organizations dedicated to the eradication of this disease, a relaxed attitude towards the development of new antimalarial entities would be flawed. Due to the emergence of resistance in the parasite, the almost 50% world-wide reduction in malarial death rates that have been produced over the past 15 years are threatening to be lost New drugs are urgently needed and our approach focuses on the re-evaluation and optimization of the historic antimalarial ICI 56,780. Due to its causal prophylac

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Gao, Rong. "DESIGN, SYNTHESIS AND EVALUATION OF NOVEL MUSCARINIC LIGANDS." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/232219.

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Pharmaceutical Sciences<br>Ph.D.<br>Muscarinic receptors are G-protein-coupled receptors that mediate the response to acetylcholine released from parasympathetic nerves. Although five mAChR subtypes (M1-M5) share a high degree of homology, they display different physiological effects including controlling smooth muscle tone to neurotransmitter release in the CNS. Hence these receptor subtypes have been investigated as potential therapeutic targets for agents capable of treating Alzheimer's Disease, Parkinson's Disease, peptic ulcer disease, COPD, urinary incontinence, and muscle spasms. Our in

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Tendjoun, Victor. "Synthese d'aminoacides et derives precurseurs d'hydantoines et de piperazine-2,5-diones spiranniques potentiellement immunomodulateurs (doctorat : sciences pharmaceutiques)." Besançon, 1997. http://www.theses.fr/1997BESA3516.

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Soares, José António Baptista Machado. "Estudo in silico da relação estrutura-actividade de piperazinas nos receptores 5-HT1A e 5-HT2A." Master's thesis, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/20782.

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Soares, José António Baptista Machado. "Estudo in silico da relação estrutura-actividade de piperazinas nos receptores 5-HT1A e 5-HT2A." Dissertação, Faculdade de Farmácia da Universidade do Porto, 2008. http://hdl.handle.net/10216/20782.

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MASHONDI, MOHAMED. "Synthese regiospecifique et regioselective d'aminosaccharides et de piperazino-saccharides a visee therapeutique." Amiens, 1996. http://www.theses.fr/1996AMIE0105.

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Ce travail decrit la synthese de deux familles d'aminosaccharides a visee therapeutique. La premiere gamme comprend des derives du d-galactose, du d-glucose, du d-xylose et du xylitol, sur lesquels ont ete greffes par l'intermediaire d'une jonction aminee, soit une chaine n-alkyle soit un groupement phenylalkyle. Trois methodes ont ete utilisees, sur le site anomerique ; condensation d'une amine primaire, sur les sites primaires : greffe du nh#3 ou de rnh#2 apres activation, sur les sites secondaires, d'abord preparation d'un aminosaccharide selon la sequence suivante, activation, azidation, r

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Nsanzubuhoro, Consolata Nsanzimpaka. "Piperazine-based pyrido[1,2-a]benzimidazoles: synthesis and pharmacological evaluation as potential antimalarial and antischistosomal agents." Master's thesis, Faculty of Science, 2018. http://hdl.handle.net/11427/30112.

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The emergence and spread of parasites resistant to first-line antimalarial drugs comprising artemisinin combination therapies (ACTs) threaten malaria control. There is therefore a need to develop novel and chemically diverse alternatives that are safe, efficacious, and able to circumvent drug resistance. Schistosomiasis is the second most prevalent tropical disease in the world after malaria, and treatment relies on a single drug: praziquantel. Although praziquantel shows multiple benefits over drugs previously used to treat schistosomiasis, dependence on it will result in therapeutic limitati

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Guerra, Filipe Alves. "Determinação da ketamina e piperazinas por cromatografia gasosa - espectrometria de massa em tandem em amostras de plasma." Master's thesis, Universidade da Beira Interior, 2013. http://hdl.handle.net/10400.6/1641.

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A dissertação encontra-se dividida em três capítulos. O primeiro capítulo descreve o trabalho de investigação desenvolvido no Centro de Investigação em Ciências da Saúde da Universidade da Beira Interior. No segundo e terceiro capítulos estão descritos os estágios realizados na Farmácia Hospitalar e na Farmácia Comunitária, respetivamente. Aqui, as principais atividades desenvolvidas e deveres assumidos no Hospital Sousa Martins e na Farmácia Mousaco Torrão são referidos, com especial ênfase na importância do farmacêutico como elemento chave a nível dos cuidados de saúde. Atualmente, o uso de

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Andrades, Lagos Juan Andrés. "Estudio de síntesis y acoplamiento molecular inducido de nuevos derivados N-{4-[4-(1H-indol-2-carbonil)-1-piperazinil]fenilarilamidas : hetero bis-ligandos con potencial actividad serotoninérgica 5-HT1A en la búsqueda de nuevas moléculas antidepresivas." Tesis, Universidad de Chile, 2013. http://www.repositorio.uchile.cl/handle/2250/114226.

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Memoria para optar al título de Químico Farmacéutico<br>Estudios de funcionalización del 1H-indol-2-acido carboxílico, condujeron a la síntesis de una familia de compuestos N-{4-[4-(1H-Indol-2-carbonil)-1-piperazinil]-fenil}- arilamidas 4(a-h) con potencial actividad serotoninérgica en el sistema nervioso central. La obtención de este grupo de compuestos cursó en una secuencia de 3 pasos, obteniéndose con rendimiento global moderado. La secuencia sintética utilizada se inició mediante la reacción del 1H-indol-2-acido carboxílico con N,N´-Diciclohexilcarbodiimida y 4-nitro-fenilpiperazina

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Pérez, Antifil Nelsón Jesús. "Estudio de síntesis y acoplamiento molecular inducido de nuevos derivados N-4-[4-(1H-indol-3-carbonil)-1-piperazinil]fenil}arilamidas (aminas) : hetero bis-ligandos con potencial actividad serotoninérgica 5-HT1A en la búsqueda de nuevas moléculas antidepresivas." Tesis, Universidad de Chile, 2012. http://repositorio.uchile.cl/handle/2250/111228.

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Memoria para optar al título de Químico Farmacéutico<br>Estudios de funcionalización del 1H-indol, condujeron a la familia de N-{4-[4-(1H-Indol-3-carbonil)-1-piperazinil]-fenil}-arilamidas 6(a-h) (Familia I) como potenciales ligandos provistos de acción serotoninérgica en el sistema nervioso central. La obtención de esta familia tomó lugar en una secuencia de 5 pasos, obteniéndose con rendimiento de un 66- 77% en la última etapa. La secuencia sintética utilizada se basó en la reacción inicial de Vilsmeier-Haack para obtener el 3-formil-1H-indol (2), en un 97%, posterior oxidación a su derivad

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Goossens, Laurence. "Conception, synthese et etude de nouveaux ligands des recepteurs nk1 de la substance p (doctorat : pharmacochimie)." Lille 2, 2000. http://www.theses.fr/2000LIL2P254.

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Numa, Mehdi Michel Djamel. "Synthesis of a #NU#, #NU#'-dialkyl piperazine #NU#, #NU#,-dioxide #bait and switch' hapten for proteolytic antibodies." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247571.

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RONDU, FREDERIC. "Synthese et etude pharmaco-toxicologique de derives de la piperazine actifs sur le diabete non-insulino-dependant." Paris 7, 1996. http://www.theses.fr/1996PA077120.

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Le diabete non-insulino-dependant se caracterise notamment par un dysfonctionnement de la regularion nerveuse de la secretion d'insuline par les cellules b du pancreas. Nous avons ainsi envisage la synthese de nouvelles molecules antagonistes du recepteur alpha-2 en nous appuyant sur une etude prealable de modelisation moleculaire. Tous les composes ont ete testes in vivo sur un modele de rat non-insulino-dependant et ont fait l'objet d'une etude in vitro sur les recepteurs alpha-2, i1 et i2. Une molecule s'est averee particulierement interessante et nous permet d'envisager la decouverte d'une

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Ward, Jessamyn. "Surface-enhanced Raman spectroscopy (SERS) for the qualitative analysis of synthetic piperazines." Thesis, 2017. https://hdl.handle.net/2144/26942.

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Designer drugs are some of the most commonly abused substances in the world. They are synthesized through slight chemical modifications of existing substances, evading the law while maintaining the desired effects of the pharmaceutical or illicit substance. These drugs are often marketed as “herbal” or “natural,” but are fully synthetic. Due to their constant, rapid emergence, there is a need for a rapid method of identification, both in the field as well as in the laboratory. One group of these designer drugs are synthetic piperazines. Named for the piperazine ring found in their chemical st

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Lau, Timothy Wan Tsun. "Investigation in stability of eight synthetic piperazines in human whole blood under various storage conditions over time." Thesis, 2017. https://hdl.handle.net/2144/23812.

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Over the past decade, synthetic piperazines have been associated with multiple fatalities and was one of the top 25 identified drugs in 2011. While circumventing legislative controls and preventing the detection in standard drug tests, synthetic piperazine derivatives are encountered in forensic casework as “legal” alternatives to ecstasy (3,4-methylenedioxymethamphetamine). These chemically-produced compounds share very similar pharmacological and psychological effects with ecstasy which in turn has led to their popularity as “party pills”. The long-lasting duration of synthetic piperazines,

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LeBlanc, Raquel Alecia. "Method development and validation for the quantification of eight synthetic piperazines in blood and urine using liquid chromatography-tandem mass spectrometry (UFLC-ESI-MS/MS)." Thesis, 2016. https://hdl.handle.net/2144/19186.

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Synthetic piperazines are chemically-produced compounds that contain a six-member ring with two opposing nitrogen atoms. Several piperazine derivatives, namely 1- benzylpiperazine (BZP), 1-(3-trifluoromethylphenyl)-piperazine (TFMPP), and 1-(3- chlorophenyl)-piperazine (mCPP), have fallen into the “designer drugs” category due to their increasing recreational use as a “legal” alternative to ecstasy (3,4-methylenedioxymethamphetamine). These compounds share similar stimulant and physiological effects with amphetamines which make them desirable to young adults in party-type atmospheres. BZP, a S

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Silva, Maria João Leal Ferreira da. "Avaliação da Influência do Metabolismo na Interacção Toxicológica entre Duas Piperazinas Correntemente Utilizadas como Drogas de Abuso, a Benzilpiperazina (BZP) e a 1-(3-Trifluormetilfenil) Piperazina (TFMPP)." Master's thesis, 2014. https://repositorio-aberto.up.pt/handle/10216/76926.

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