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Dissertations / Theses on the topic 'Piperidina'

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Published: 4 June 2021

Last updated: 5 February 2022

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1

Kawamura, Meire Yasuko. "Emprego de diazocetonas α,β-insaturadas com geometria Z na direta construção de esqueletos indolizidínicos e piperidínicos funcionalizados." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-26082016-104019/.

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Pumiliotoxinas e seus congêneres são compostos isolados da pele de algumas espécies de sapos das famílias Dendrobatidae, Mantellidae, Bufonidae, e Myobatrachidae, apresentando interessantes propriedades farmacológicas. As pumiliotoxinas, embora tóxicas, apresentam consideráveis atividades cardiotônicas, assim, acredita-se que as homopumiliotoxinas, as desmetilpumiliotoxinas e as desidrodesmetilpumiliotoxinas também devam apresentar. Nesse sentido, a síntese destes compostos é de extrema valia para a comunidade científica. As diazocetonas α,β-insaturadas são intermediários promissore

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2

Chaves, Henrique Koch. "O efeito do substituinte no anel piperidina na reatividade de pré-catalisadores do tipo [RuCl2(PPh3)2(4-CH2X-pip)] em ROMP." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/75/75132/tde-17102011-153731/.

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As moléculas de 4-CH2X-piperidinas, X = OH (1), H (2) e Ph (3) foram investigadas como ligantes ancilares nos novos complexos [RuCl2(PPh3)2(4-CH2X-pip)] para a polimerização via metátese por abertura de anel (ROMP) de norborneno (NBE) e norbornadieno (NBD). Os complexos foram obtidos pela síntese com [RuCl2(PPh3)3] e caracterizado por análise elementar de CHN, infravermelho e RMN 31P {1H}. Os resultados sugeriram moléculas pentacoordenadas com ambos os íons cloreto e ambos os ligantes fosfinas trans-posicionados em uma geometria pirâmide de base quadrada em cada caso; a amina está no eixo axia

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3

Montes, d'Oca Marcelo Gonçalves. "Avaliação do acido S-(+)-O- acetil-mandelico como auxiliar quiral na adição de aliltrimetilsilano a ions N-aciliminios ciclicos derivados da pirrolidina e piperidina." [s.n.], 1995. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249234.

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Orientador: Ronaldo A. Pilli<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-07-20T03:46:16Z (GMT). No. of bitstreams: 1 Montesd'Oca_MarceloGoncalves_M.pdf: 1493991 bytes, checksum: 391d19bf2ac2786b42ca40e281d8a167 (MD5) Previous issue date: 1995<br>Mestrado

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4

Khan, Abdul Majeed 1980. "Síntese e termoquímica de adutos de brometos de metais bivalentes com aminas hetrocíclicas." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249123.

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Orientador: Pedro Oliver Dunstan Lozano<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Química<br>Made available in DSpace on 2018-08-22T07:28:40Z (GMT). No. of bitstreams: 1 Khan_AbdulMajeed_D.pdf: 3004508 bytes, checksum: 1d8c778094bf0cb1b93fa7bf80e19074 (MD5) Previous issue date: 2013<br>Resumo: Os adutos MX2.nL (M = Mn, Fe, Co, Ni, Cu ou Zn, L = 3-cianopiridina, piperidina ou piperazaina, X = Br, n = 0,5, 0,75, 1, 1,5, 2 ou 4), foram sintetizados e caracterizados através de análise elementar, determinação de pontos de fusão, espectroscopia IV e eletrônica e análise

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5

Rosset, Isac George. "Diazocetonas α,β-insaturadas como reagentes multifuncionais: aplicação na síntese de alcaloides piperidínicos e pirrolidínicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-20052015-101409/.

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p>O primeira parte do trabalho descreve a preparação de um novo reagente de olefinação de HWE para o preparo de diazocetonas α, β-insaturadas com geometria Z e aplicação na síntese de núcleos piperidínicos funcionalizados. Através da otimização da reação de HWE empregando o benzaldeído como aldeído padrão foi possível maximizar a obtenção do isômero Z desejado (92%, Z:E 9:1). As reações-chave para a formação dos núcleos piperidínicos foram a de olefinação de HWE utilizando amino-aldeídos, obtendo-se bons rendimentos e boa seletividade, seguida de uma reação de inserção N-H catalisad

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6

Lewis, Neil. "Asymmetric piperidine synthesis." Thesis, University of Nottingham, 1995. http://eprints.nottingham.ac.uk/13293/.

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It has been demonstrated that bakers' yeast reduction of 1-tert-butyl-2-methyl 3-oxo-piperidine-1,2-dicarboxylate gives (2R, 3S), 1-tert-butyl-2-methyl 3-hydroxy-piperidine-1,2-dicarboxylate in 80% chemical yield with >99% d.e. and >97% e.e. Also bakers' yeast reduction of 1-tert-butyl-3-ethyl 4-oxo-piperidine-1,3-dicarboxylate gives (3R, 4S), 1-tert-butyl-3-ethyl4-hydroxy-piperidine-1,3-dicarboxylate in 74% chemical yield with >99% d.e. and >93% e.e. The optical purity and absolute configurations of the hydroxy-ester derivatives were determined by conversion into the corresponding chiral bis-

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7

Turner, Ian. "Piperidines from tetrahydroimidazoles." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334848.

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8

Taylor, Sarah Alison. "Sulfur-mediated pyrrolidine and piperidine synthesis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613286.

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9

Adriaenssens, Louis. "Stereoselective synthesis of piperidines." Thesis, Connect to e-thesis to view edited abstract. Move to record for print version, 2008. http://theses.gla.ac.uk/49/.

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10

Girling, Paul Ricardo. "Novel approaches to piperidine and hydropyridine derivatives." Thesis, Durham University, 2012. http://etheses.dur.ac.uk/6354/.

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Three new modes of reactivity are reported between the reaction of an imine, but-3-en-2-ones and a Lewis acid. These are formal [2+2+2]-, [1+2+1+2]- and [4+2]- cycloadditions, deriving 1,1'-(1,2-dihydropyridine-3,5-diyl)diethanones, 1,1'-(1,4-dihydropyridine-3,5-diyl)diethanones and piperidin-4-ones and respectively. The [2+2+2]- and [1+2+1+2]-cycloadditions proceed when R3 = LG (leaving group), with the [1+2+1+2]-pathway dominating when the imine is easily hydrolysed within the reaction conditions. When R3 ≠ LG, the cycloaddition proceeds through different [4+2]-mechanistic pathways, dependen

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11

Adams, David Roger. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236570.

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12

Mosts, R. C. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379495.

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13

Eskici, Mustafa. "Asymmetric piperidine synthesis via 1,3-cyclic sulfates." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368215.

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14

Woods, Gordon Alexander. "Synthetic approaches to functionalised piperidines." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4c6fdb6c-c021-447c-8fc9-35241b552850.

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This thesis is concerned with the synthesis of functionalised piperidines. The piperidine unit is found in numerous alkaloids and other natural products, and has also been incorporated into synthetic compounds of significant therapeutic or strategic synthetic potential. Although numerous syntheses of individual piperidine compounds have been published, there are few general routes to this class of compounds, and there is therefore a need for such routes to be developed. Bicyclic lactams derived from (S)-pyroglutamic acid have been shown to be useful synthons in the synthesis of pyrrolidines. A

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15

Ottersbach, Dirk. "Dehydrierung n-substituierter Delta3-Piperideine /." [S.l. : s.n.], 1988. http://www.gbv.de/dms/bs/toc/025230328.pdf.

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16

Williams, Jodi Thomas. "Stereoselective piperidine synthesis via ene and carbonyl ene cyclisations." Thesis, Oxford Brookes University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289247.

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17

Lenagh-Snow, Gabriel Matthew Jack. "The synthesis of azetidine and piperidine iminosugars from monosaccharides." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:207235d5-2ea5-4724-92fd-924fa0ccd4ed.

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Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen. A common affect of this atomic substitution is to bestow these compounds with the ability to inhibit various sugarprocessing enzymes; most significantly the glycosidases (glycoside hydrolases) which areintimately involved in a huge array of biological functions. Compounds which inhibit these enzymes concordantly possess much potential as medicinal agents for the treatment of a variety of diseases. Several iminosugars have alread

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18

Williams, Meredith Richard Vaughan. "Sulfone-mediated synthesis of enantiopure piperidines." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299202.

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19

McGrane, Emma Scott. "Novel approaches towards pyrrolidines and piperidines." Thesis, Kingston University, 2004. http://eprints.kingston.ac.uk/20731/.

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20

Cariou, Claire. "Diastereoselective synthesis of 2,4,5-trisubstituted piperidines." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434701.

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21

Bergman, Zara Dominique. "2,3,4-trisubstituted piperidines : a stereocontolled approach." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5794/.

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This thesis details a methodology utilising various synthetic pathways towards cyclisation precursors suitable for use in Prins and carbonyl-ene cyclisations to effect 2,3,4-trisubstituted piperidines. Once the precursors were synthesised, we were interested in the stereochemical outcomes of the cyclisations, in particular identity and rational of the kinetic and thermodynamic products and their variation due to differing substituents on C2. Previous work in the Snaith group has addressed various other substitution patterns and 2,3,4-trisubstituted piperidines are central components of a vast

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22

Abdelsalam, Mansour. "Synthesis of piperidines using organometallic chemistry." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4069/.

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23

Stapper, Christian. "Ringumlagerungen und Synthese von Piperidin- und Pyrrolidinalkaloiden durch Olefinmetathese." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962764485.

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24

Archibald, Glenn Philip. "Use of novel nitrones in the synthesis of piperidine alkaloids." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7127.

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The current study focused on development of a flexible synthetic strategy for the enantioselective preparation of 2-substituted-3-hydroxypiperidines utilising chiral 3-hydroxytetrahydropyridine N-oxides. Initial studies into the regio- and stereoselectivity of the 1,3-dipolar cycloaddition reaction between O-benzyl protected 3-hydroxytetrahydropyridine N-oxide 208 and a range of alkenes, proceeded with excellent exo/endo selectivity and near perfect regioselectivity. However the anti/syn selectivity was only moderately in favour of the desired anti-compounds. Further development has led to the

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25

Ferrari, Frank D. "Flexible synthesis of spirocyclic pyrans and piperidines." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3829/.

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Spirocyclic piperidines and spirocyclic pyrans are prevalent throughout nature, often appearing in natural products which exhibit exciting biological activities. Notable examples of spirocyclic piperidine-containing biologically active natural products are halichlorine, pinnaic acid and tauropinnaic acid. Despite their structural similarity, halichlorine and the pinnaic acids were isolated from separate organisms; halichlorine was isolated from extracts of the marine sponge Halichondria okadai while both pinnaic acid and tauropinnaic acid were isolated from the Okinawan bivalve mollusc Pinna m

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26

Mould, Roger James. "Aza-Wittig rearrangement of aziridines to piperidines." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296237.

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27

Smith, Peter Duncan. "Synthesis of pipecolic acid derivatives via aza-Diels-Alder reactions." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/552.

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28

Moore, Rebecca J. "Novel approaches to natural product synthesis using organozinc intermediates." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362516.

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29

Coggins, P. "Syntheses with 2-alkyl-2,3,4,5-tetrahydropyridine-1-oxides." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235969.

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30

Bockelmann, Maria Alice. ""Adição diastereosseletiva de enolatos de titanio a ions N-aciliminio ciclicos : estudos visando a sintese de alcaloides e a sintese assimetrica do farmaco cloridrato de (+)-fenidato de metila"." [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/249273.

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Orientador: Ronaldo Aloise Pilli<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Quimica<br>Made available in DSpace on 2018-08-04T03:24:13Z (GMT). No. of bitstreams: 1 Bockelmann_MariaAlice_D.pdf: 38380135 bytes, checksum: ccd3fbf3780ed6acdc817e4423cdfafd (MD5) Previous issue date: 2004<br>Doutorado<br>Quimica Organica<br>Doutor em Quimica

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31

Gandon, Lucile Alice. "A radical sterocontrolled synthesis of 2,4-disubstituted piperidines." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403012.

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32

Hutchinson, Ian Paul. "The synthesis of 3-substituted-2-(nitromethylene)-piperidines." Thesis, University of Warwick, 1994. http://wrap.warwick.ac.uk/104212/.

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The class of insecticides known collectively as the nitromethylene heterocycles (NMHs) were discovered in the late 1970's. The NMHs are a group of compounds that are particularly active against certain insects, exhibit low toxicity to vertebrates and are non-persistent in the environment. Their site of action is on the cholinergic synapse where they act as agonists at the post-synaptic nicotinic acetylcholine receptors. Research into developing these types of compounds has led to a wide range of analogues being synthesised, resulting in a wide variety of activities. Analogues of 2- (nitromethy

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33

Mathieu, Hélène. "Syntheses asymetriques de piperidines fonctionnalisees a partir d'acyloxazolidines." Paris 6, 1998. http://www.theses.fr/1998PA066231.

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Une reaction de condensation entre un aminoalcool enantiopur et un aldehyde fonctionnalise suivie d'une carbamation stereoselective a permis d'acceder a des cetooxazolidines diastereoisomeriquement pures avec un groupe tert-butoxycarbonyle comme groupe protecteur de la fonction amine. Des etudes realisees concernant la stereoselectivite de la reduction de la fonction carbonyle, placee soit en , soit en du c-2 de l'oxazolidine, ont montrees que l'induction asymetrique de la couple chirale etait plus efficace dans le cas d'un transfert de chiralite 1,2 (c = o en ) que 1,3 (c = o en ). L'obtentio

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34

Cochrane, Edward. "Synthesis of substituted piperidines using chiral organolithium chemistry." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6622/.

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35

Adelbrecht, Jean-Claude. "Bis (arylsulfonyl) tetrahydropyridines : application to the synthesis of piperidines." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406619.

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36

Hughes, Mark Charles. "The development of new approaches to stereoselective functionalised piperidines." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342543.

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37

Aeyad, Tahani. "Synthesis of substituted azepanes and piperidines using organolithium chemistry." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20712/.

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α-Amino-organolithium compounds represent an important class of intermediates due to their excellent nucleophilic reactivity and importance in synthetic organic chemistry. This thesis describes some novel aspects of the n-BuLi mediated lithiation‒substitution of N-Boc heterocycles, including N-Boc-2-substituted azepane, benzazepine and piperidine derivatives.

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38

Yau, K. C. "The asymmetric synthesis of oxo-piperidines and oxo-pyrrolidines." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1451240/.

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Chapter 1 describes the attempts to synthesize piperidin-2-ones via an aza-Michael-Michael annulation, which were unsuccessful. A general route for the synthesis of piperidin-2,4-diones from β-keto esters via a Dieckmann cyclisation was proposed and five piperidin-2,4-diones with different substituents at positions-5 and -6 were prepared. An asymmetric route to 1-unsubstituted piperidin-2,4-diones was also developed which involved the use of Davies' chiral auxiliary to induce an asymmetric Michael addition. Chapter 2 describes a new approach to the synthesis of codeine. The piperidin-4-one rin

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39

Launay, Guillaume. "New approaches for C-F bond formation in organic chemistry." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/922.

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The importance of fluorinated organic molecules has grown over the last 50 years, particularly in the pharmaceutical and agrochemical industries. Therefore the development of new methods for fluorination is a very attractive research area. In Chapter 1, the properties and impact of the fluorine atom on organic molecules are overviewed. Existing electrophilic and nucleophilic fluorination methods are reviewed, and new developments in asymmetric fluorination are discussed. The emergence of the Prins fluorination reaction as a side product in BF₃.OEt₂ catalysed processes has been investigated as

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40

Contro, Janine [UNESP]. "Síntese e caracterização espectroscópica de novos vanadosilicatos utilizando templates orgânicos derivados de piperidinas." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/137850.

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Submitted by Janine Contro null (janinecontro@yahoo.com.br) on 2016-04-07T18:56:18Z No. of bitstreams: 1 DISSERTAÇÃO - JANINE.pdf: 7764303 bytes, checksum: a8fc2422ef9a7fc1ce8eef29ce54e487 (MD5)<br>Approved for entry into archive by Felipe Augusto Arakaki (arakaki@reitoria.unesp.br) on 2016-04-08T12:32:48Z (GMT) No. of bitstreams: 1 contro_j_me_sjrp.pdf: 7764303 bytes, checksum: a8fc2422ef9a7fc1ce8eef29ce54e487 (MD5)<br>Made available in DSpace on 2016-04-08T12:32:48Z (GMT). No. of bitstreams: 1 contro_j_me_sjrp.pdf: 7764303 bytes, checksum: a8fc2422ef9a7fc1ce8eef29ce54e487 (MD5) Previo

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Contro, Janine. "Síntese e caracterização espectroscópica de novos vanadosilicatos utilizando templates orgânicos derivados de piperidinas /." São José do Rio Preto, 2016. http://hdl.handle.net/11449/137850.

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Orientador: José Geraldo Nery<br>Banca: Ariano de Giovanni Rodrigues<br>Banca: Valmir Fadel<br>Resumo: Foram sintetizados neste trabalho novos vanadosilicatos, para suas sínteses foram utilizadas moléculas orgânicas derivadas de 3,5-dimetilpiperidina (SDAs 1 - 4) e 2,6-dimetilpiperidina (SDAs 5 - 8) em sua mistura reacional. Os vanadosilicatos foram nomeados seguindo a numeração dos SDAs utilizados em suas sínteses (VN1 a VN8). As caracterizações físico-químicas dos vanadosilicatos foram realizadas utilizando-se técnicas como difração de raios-X (DRX), microscopia eletrônica de varredura (MEV)

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42

Gu, Xiaobo. "Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1111.

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Meperidine has been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake inhibitors (SSRIs). A variety of potent analogues of meperidine have been synthesized and evaluated in vitro as potential ligands for the serotonin transporter. Substitutions have been made on the aryl ring, the ester moiety and the piperidine nitrogen of meperidine. Potent analogues o

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43

Mancey, Nicole Claire. "Investigations Intro [3+3] Cycloadditions for the synthesis of piperidines." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522345.

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44

Österlund, Modalen Åsa. "Opioids and regulation of breathing /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-123-7/.

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45

Moraux, Thomas. "Synthesis and evaluation of α-fluoro analogues of capsaicin and 2-(aminomethyl)piperidine derivatives". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2094.

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Chapter 1 gives an overview of the fluorine chemistry field, from its early developments to recent applications in medicinal chemistry. The development of asymmetric electrophilic or nucleophilic installation of fluorine in organic molecules is highlighten. Chapter 2 of this thesis discusses the enantioselective synthesis of α-fluoroamides. The study is applied to the synthesis of fluoroenantiomers of the bioactive molecule capsaicin and short-chain analogues. The biological activity of these compounds is assayed with the TRPV1 receptor. Results show that enantioselective α-fluoroamides (R)-97

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46

FERNANDES, Ítalo Antônio. "Síntese e avaliação de derivados piperidino-benzodioxola planejados como novos candidatos a fármacos leishmanicidas." Universidade Federal de Alfenas, 2013. https://bdtd.unifal-mg.edu.br:8443/handle/tede/284.

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As doenças parasitárias continuam sendo um sério desafio de saúde pública, principalmente em países subdesenvolvidos ou em desenvolvimento. Dentre as diversas parasitoses existentes, pode-se destacar a leishmaniose, endêmica em vários países localizados nas regiões tropicais e subtropicais do globo terrestre. Ainda hoje, milhões de pessoas adquirem a infecção e milhares vão a óbito devido às complicações da doença quando não diagnosticada e tratada corretamente. Pesquisas voltadas à busca de tratamentos mais efetivos e seguros de doenças consideradas de países que negligenciam tais são de sum

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47

Silvestrini, Filippo. "A DFT study on chemodivergent preparation of piperidinic and morpholinic heterocycles." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20660/.

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The topic of this thesis is the DFT computational study of the mechanisms for the synthesis of chiral 3,4,5-trisubstituted piperidines and 2,6-disubstituted morpholines. The goal of this synthesis is to use, the same substrate containing two electrophilic sites: an α,β-unsaturated ester and a ketone, which evolve according to the nucleophile used (cyanide, phenyl sulfide) through different addition and cyclization reactions. A quaternary ammonium salt is used as a catalyst for these reactions, which leads to a diastereoisomeric excess both for the reactions of morpholine and piperidine product

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48

Goldspink, Nicholas J. "Asymmetric synthesis of piperidines using the chiral lithium amide base approach." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364649.

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Sadler, Matthew James. "Diastereoselective synthesis of 2,4,5 trisubstituted piperidines : application in natural product synthesis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2901/.

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This thesis describes the diastereoselective synthesis of 2,4,5-trisubstituted piperidines using carbonyl-ene and Prins cyclisations and their application in natural product synthesis. Following on from previous work in the group, we investigated how a preinstalled substituent in the 2-position can help to control the sense of induction at the two newly forming stereocentres. We utilised the Prins reaction in the formal synthesis of pseudodistomin F, a marine alkaloid that posses a 2,4,5-tribsubstituted piperidine core. An initial first generation synthesis focused on the construction of a cyc

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50

CARBONNEL, SYLVIE. "Syntheses stereoselectives de piperidines polysubstituees d'interet biologique derivees de l'acide pipecolique." Clermont-Ferrand 2, 2001. http://www.theses.fr/2001CLF22273.

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Abstract:

Ce travail decrit une nouvelle methode d'acces a des composes piperidiniques derives de l'acide pipecolique. Une reaction de cyclisation intramoleculaire de type mannich, impliquant un aldehyde et une beta-aminocetone protegee, permet la creation du cycle piperidinique. La fonction ester peut etre introduite sur ce cycle par l'intermediaire de l'un ou l'autre des precurseurs et les deux voies de synthese correspondantes ont ete mises au point. La premiere voie fait intervenir un ester glyoxylique et une beta-aminocetone protegee alpha-alkylee. La diastereoselectivite de la reaction est alors s

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