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Relevant bibliographies by topics / Piperidine alkaloids

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Academic literature on the topic 'Piperidine alkaloids'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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Journal articles on the topic "Piperidine alkaloids"

1

Virjamo, V., and R. Julkunen-Tiitto. "Variation in piperidine alkaloid chemistry of Norway spruce (Picea abies) foliage in diverse geographic origins grown in the same area." Canadian Journal of Forest Research 46, no. 4 (2016): 456–60. http://dx.doi.org/10.1139/cjfr-2015-0388.

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Volatile piperidine alkaloids are widespread compounds found in low amounts in coniferous species. Here, we investigated the variation of piperidine alkaloid chemistry of Norway spruce (Picea abies (L.) Karst.) in a provenance-type experiment. Volatile piperidine alkaloids were analysed from current-year mature needles of 12 geographical origins grown for 35 years at the same site. Results indicate that, despite long-lasting similar growth conditions, origins were still showing different alkaloid composition and concentrations, indicating solid genotype variation. The highest total piperidine

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Tilve, Santosh, Sandesh Bugde, and Prajesh S.Volvoikar. "Protecting-Group-Directed Regio- and Stereoselective Oxymercuration–Demercuration: Synthesis of Piperidine Alkaloids Containing 1,2- and 1,3-Amino Alcohol Units." Synthesis 50, no. 05 (2017): 1113–22. http://dx.doi.org/10.1055/s-0036-1589523.

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An efficient synthesis of naturally occurring 1,2- and 1,3-amino alcohol unit containing 2-substituted piperidine alkaloids and their analogues has been developed from l-pipecolinic acid. The protocol describes the regio- and stereoselective oxymercuration–demercuration of 2-alkenyl piperidines based on protecting groups to give piperidine alkaloids as a key step.

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Poulsen, Thomas B., and Gustav J. Wørmer. "The [4.3.0] Piperidine Alkaloids: Architectures, Biology, Biosyntheses, and the Complete Details of the Asymmetric Syntheses of Streptazone A and Abikoviromycin." Synlett 33, no. 07 (2021): 637–54. http://dx.doi.org/10.1055/a-1688-0826.

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AbstractPiperidine alkaloids continue to challenge the synthetic community by featuring densely functionalized scaffolds that often require careful chemical orchestration. Streptazone A and abikoviromycin are small and highly functionalized piperidine alkaloids, both accommodating Michael acceptors and a labile epoxide. These moieties are loaded into a [4.3.0] bicyclic core also present in other structurally related natural products, including the well-known piperidine alkaloid streptazolin. Here, we cover ring-closing strategies employed in earlier streptazolin syntheses; provide a concise ov

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4

Enders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.

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Recent advances in the diastereo- and enantioselective synthesis of piperidine, pyrrolidine, and indolizidine alkaloids, based on the highly stereoselective 1,2-addition to the CN double bond of chiral aldehyde-SAMP/RAMP hydrazones, are described. The enantioselective syntheses of the pyrrolidine alkaloids bgugaine and (2S,12¢R)-2-(12¢-aminotridecyl)-pyrrolidine, a defense alkaloid of the Mexican bean beetle are reported. Furthermore, the SAMP/RAMP-hydrazone method was applied to the syntheses of two 5,8-disubstituted indolizidine alkaloids that have been extracted from neotropical poison-dart

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Frolov, Nikita A., and Anatoly N. Vereshchagin. "Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications." International Journal of Molecular Sciences 24, no. 3 (2023): 2937. http://dx.doi.org/10.3390/ijms24032937.

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Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in the pharmaceutical industry. Their derivatives are present in more than twenty classes of pharmaceuticals, as well as alkaloids. The current review summarizes recent scientific literature on intra- and intermolecular reactions leading to the formation of various piperidine derivatives: substituted piperidines, spiropiperidines, condensed piperidines, and piperidinones. Moreover, the pharmaceutical applications of synthetic and natural piperidines were covered, as well as the latest s

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6

Putri, Ayu Darma, and Icha Putri Winata. "Pengaruh Pemberian Ekstrak Spirulina terhadap Antikanker." Jurnal Penelitian Perawat Profesional 1, no. 1 (2019): 103–8. http://dx.doi.org/10.37287/jppp.v1i1.27.

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Spirulina adalah cyanobacterium mikroskopik berfilamen, mengandung bahan yang bermanfaat bagi manusia antara lain alkaloid, flavonoid, steroid, saponin, dan senyawa aktif piperidinone, piperidine, hexadecanenitrile yang merupakan zat dengan aktivitas kemopreventif kanker yang poten. Zat ini mampu menginduksi apoptosis dengan menimbulkan fragmentasi DNA dan kondensasi nucleus dan juga memiliki kemampuan untuk menurunkan regulasi protein anti apoptosis dan meningkatkan regulasi protein proapoptosi. Tujuan literature review ini untuk mengetahui efek ekstrak spirulina terhadap antikanker. Penulisa

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Bonandi, Elisa, Giada Tedesco, Dario Perdicchia, and Daniele Passarella. "Total Synthesis of (–)-Anaferine: A Further Ramification in a Diversity-Oriented Approach." Molecules 25, no. 5 (2020): 1057. http://dx.doi.org/10.3390/molecules25051057.

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The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, employing commercially available 2-piperidine ethanol as a versatile precursor. Here, we report the exploration of another ramification of our DOS approach, that led us to the stereoselective total synthesis of (–)-anaferine, a bis-piperidine alkaloid present in Withania somnifera extract. This natural product

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Miguel, Obdulio G., Adair R. S. Santos, João B. Calixto, Franco Delle Monache, and Rosendo A. Yunes. "Antinociceptive Activity of the Natural Piperidine Alkaloid Hydrochlorides from Syphocampylus verticellatus." Zeitschrift für Naturforschung C 57, no. 1-2 (2002): 81–84. http://dx.doi.org/10.1515/znc-2002-1-214.

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In addition to 3′-methoxyluteolin and mixtures of sterols and triterpenes, the leaves of Syphocampylus Verticellatus yielded two piperidine alkaloid hydrochlorides, one of them has a novel structure. The alkaloids exhibit antinociceptive activity.

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9

Samoylenko, Volodymyr, D. Chuck Dunbar, Melissa R. Jacob, Vaishali C. Joshi, Mohammad K. Ashfaq, and Ilias Muhammad. "Two New Alkylated Piperidine Alkaloids from Western Honey Mesquite: Prosopis glandulosa Torr. var. torreyana." Natural Product Communications 3, no. 1 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300108.

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Prosopis glandulosa Torr. var. torreyana (L. Benson) M. C. Johnston root bark, collected in Texas, yielded two new alkylated piperidine alkaloids, namely 3-isocassine (1) and N-methyl-3-isocassine (2), together with the previously reported N-methylcassine (3). In addition, the alkylated piperidinyl indolizidine alkaloid juliprosopine (4) was isolated from the leaves of the same plant. The structures and stereochemistry of compounds 1–4 were determined from 1D and 2D NMR data, including COSY, HMQC, HMBC and NOESY experiments, and ESI-HRMS. Juliprosopine (4) demonstrated antimicrobial activities

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Guzmán-Rodríguez, Sergio, Jesús Chávez-Reyes, Priscila Vázquez-León, et al. "1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats." Pharmacology 106, no. 5-6 (2021): 305–15. http://dx.doi.org/10.1159/000513376.

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<b><i>Background:</i></b> Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 se

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Dissertations / Theses on the topic "Piperidine alkaloids"

1

Adams, David Roger. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236570.

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Mosts, R. C. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379495.

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Dumare, N. B. "Synthetic studies towards mitralactonine, pipecolic acid and piperidine alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1920.

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Archibald, Glenn Philip. "Use of novel nitrones in the synthesis of piperidine alkaloids." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7127.

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The current study focused on development of a flexible synthetic strategy for the enantioselective preparation of 2-substituted-3-hydroxypiperidines utilising chiral 3-hydroxytetrahydropyridine N-oxides. Initial studies into the regio- and stereoselectivity of the 1,3-dipolar cycloaddition reaction between O-benzyl protected 3-hydroxytetrahydropyridine N-oxide 208 and a range of alkenes, proceeded with excellent exo/endo selectivity and near perfect regioselectivity. However the anti/syn selectivity was only moderately in favour of the desired anti-compounds. Further development has led to the

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Moore, Rebecca J. "Novel approaches to natural product synthesis using organozinc intermediates." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362516.

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Coggins, P. "Syntheses with 2-alkyl-2,3,4,5-tetrahydropyridine-1-oxides." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235969.

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Upadhyay, P. K. "Development of new methodology using phosphorus ylides and enantioselective synthesis of pyrrolidine and piperidine alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2009. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2768.

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8

Pivatto, Marcos [UNESP]. "Estudo fitoquímico dos frutos de Senna spectabilis e análise comparativa do perfil alcaloídico de S. spectabilis e Cassia leptophylla." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/97994.

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Made available in DSpace on 2014-06-11T19:29:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-12-01Bitstream added on 2014-06-13T19:58:51Z : No. of bitstreams: 1 pivatto_m_me_araiq.pdf: 4500291 bytes, checksum: 41c36cab9b65c53f1fe92528b346a70e (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O presente trabalho objetivou o estudo fitoquímico dos frutos de Senna spectabilis e o estudo comparativo do perfil alcaloídico entre S. spectabilis e Cassia leptophylla, outra espécie vegetal relatada como fonte de alcalóides piperidínicos. O estudo fitoquímico do

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Lansakara, Ashabha Indrashika. "Intramolecular cyclizations of alkyl pyridines & alkylidene dihydropyridines as synthetic intermediates toward synthesis of bis(piperidine) alkaloids." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2105.

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Nature provides fascinating and complicated molecular structures which offer synthetic organic chemists amazing opportunities for the design of new strategies for natural product synthesis. Among these, nitrogen containing aza-heterocycles are of unparalleled importance in natural product, bioorganic, and medicinal chemistry. Pyridine and its derivatives in particular are the most common aza-heterocycles encountered in natural products, medicinal and materials chemistry. Pyridine derivatives also serve as precursors to fun

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Pivatto, Marcos. "Estudo fitoquímico dos frutos de Senna spectabilis e análise comparativa do perfil alcaloídico de S. spectabilis e Cassia leptophylla /." Araraquara : [s.n.], 2005. http://hdl.handle.net/11449/97994.

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Resumo: O presente trabalho objetivou o estudo fitoquímico dos frutos de Senna spectabilis e o estudo comparativo do perfil alcaloídico entre S. spectabilis e Cassia leptophylla, outra espécie vegetal relatada como fonte de alcalóides piperidínicos. O estudo fitoquímico dos frutos de S. spectabilis forneceu 4 alcalóides piperidínicos: cassina (1), 3-O-acetil-cassina (20), 3-O-feruloil-cassina (18) e um estereoisômero da cassina (19), cujas configurações, ralativa e absoluta, ainda não foram determinadas. Dentre estes, somente a cassina (1) já era conhecida e foi isolada, em nosso grupo de pesq

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Books on the topic "Piperidine alkaloids"

1

Oetting, Jörg. Optisch aktive [beta]-Hydroxy-carbonsäuren [Beta-Hydroxy-carbonsäuren] als Bausteine für neue Amino-hydroxy-carbonsäuren und Piperidin-Alkaloide: Stereoselektive Totalsynthese von (-)-Cassin. [s.n.], 1995.

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2

Adams, David Roger. Studies in the synthesis of piperidine alkaloids. 1990.

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3

Die Konstitutionserforschung der Alkaloide: Die Pyridin-Piperidin-Gruppe. In Kommission, Deutscher Apotheker Verlag, 1985.

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4

Hesse, Carsten. Untersuchungen zum Propenyl-Piperidein: Eine Modellsubstanz für die Biogenese der Lycopodium-Alkaloide. 1990.

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Book chapters on the topic "Piperidine alkaloids"

1

Szőke, Éva, Éva Lemberkovics, and László Kursinszki. "Alkaloids Derived from Lysine: Piperidine Alkaloids." In Natural Products. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-22144-6_10.

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2

Seigler, David S. "Pyrrolidine, Tropane, Piperidine, and Polyketide Alkaloids." In Plant Secondary Metabolism. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-4913-0_29.

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Panter, K. E., and R. F. Keeler. "Piperidine Alkaloids of Poison Hemlock (Conium Maculatum)." In Toxicants of Plant Origin. CRC Press, 2024. http://dx.doi.org/10.1201/9781003575030-5.

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4

Plunkett, Owen, and Malcolm Sainsbury. "Pyridine and piperidine alkaloids." In Second Supplements to the 2nd Edition of Rodd's Chemistry of Carbon Compounds. Elsevier, 1991. http://dx.doi.org/10.1016/b978-044453347-0.50194-4.

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"Alkaloids." In Chemical Diversity of Plant Specialized Metabolites. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671472-00218.

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Alkaloids are organic compounds containing nitrogen usually in the heterocyclic ring. True alkaloids are derived from different amino acids. Tropane alkaloids, pyrrolidine alkaloids and pyrrolizidine alkaloids are derived from the amino acid ornithine; pyridine, piperidine, quinolizidine, indolizidine, and Lycopodium alkaloids from aspartate/lysine; isoquinoline alkaloids from tyrosine; imidazole alkaloids from histidine; indole and quinoline alkaloids from tryptophan; and quinazoline alkaloids are anthranilic acid derived. Protoalkaloids are also derived from amino acids, but the nitrogen ato

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Strunz, George M., and John A. Findlay. "Chapter 3 Pyridine and Piperidine Alkaloids." In The Alkaloids: Chemistry and Pharmacology. Elsevier, 1985. http://dx.doi.org/10.1016/s0099-9598(08)60194-7.

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Schneider, Marilyn J. "Chapter Two Pyridine and piperidine alkaloids: An update." In Alkaloids: Chemical and Biological Perspectives. Elsevier, 1996. http://dx.doi.org/10.1016/s0735-8210(96)80026-4.

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Angle, S. R., and J. G. Breitenbucher. "Recent progress in the synthesis of piperidine and indolizidine alkaloids." In Stereoselective Synthesis (Part J). Elsevier, 1995. http://dx.doi.org/10.1016/s1572-5995(06)80060-8.

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9

Ojima, Iwao, and Donna M. Iula. "New Approaches to the Syntheses of Piperidine, Izidine, and Quinazoline Alkaloids by Means of Transition Metal Catalyzed Carbonylations." In Alkaloids: Chemical and Biological Perspectives. Elsevier, 1999. http://dx.doi.org/10.1016/s0735-8210(99)80028-4.

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Taber, Douglass F. "The Snyder Synthesis of Psylloborine A." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0099.

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In addition to the monomeric coccinellid alkaloids produced by the ladybug, some dimeric alkaloids, exemplified by psylloborine A 3, have been isolated. Scott A. Snyder of Scripps/Florida initially attempted a direct dimerization strategy for the assembly of 3, but when that failed, he devised (J. Am. Chem. Soc. 2014, 136, 9743) a route to the tethered dimer 1, that could indeed be cyclized to 2, the immediate precursor to 3. The starting material for both 9, the lower half of 1, and 13, the upper half of 1, was the commercial, enantiomerically-pure piperidine 4. Metalation followed by allylat

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Conference papers on the topic "Piperidine alkaloids"

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Pereira, M. L. A., L. B. Sousa, T. R. Tomich, F. S. Machado, L. B. Sousa, and L. G. R. Pereira. "Methane mitigation potential of diets supplemented with mesquite piperidine alkaloids for sheep." In 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition. Wageningen Academic Publishers, 2019. http://dx.doi.org/10.3920/978-90-8686-891-9_22.

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Pereira, M. L. A., L. B. Sousa, M. M. Campos, A. S. Silva, D. B. Oss, and L. G. R. Pereira. "Potential of diets supplemented with mesquite piperidine alkaloids for sheep: energy use." In 6th EAAP International Symposium on Energy and Protein Metabolism and Nutrition. Wageningen Academic Publishers, 2019. http://dx.doi.org/10.3920/978-90-8686-891-9_72.

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Burtoloso, Antonio C. B. "α,β-Unsaturated Diazoketones as Useful Platforms in the Synthesis of Pyrrolidine, Piperidine and Indolizidine Alkaloids". У 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-young5.

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4

Symma, N., M. Bütergerds, J. Sendker, et al. "Neue Piperidin- und 3,4-dihydro-2H-pyrrol-Alkaloide aus Lindenblüten (Tiliae flos)." In Jubiläumskongress Phytotherapie 2021 Leib und Magen – Arzneipflanzen in der Gastroenterologie 50 Jahre Gesellschaft für Phytotherapie. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0041-1731511.

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