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Dissertations / Theses on the topic 'Piperidine alkaloids'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Adams, David Roger. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236570.

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2

Mosts, R. C. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379495.

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3

Dumare, N. B. "Synthetic studies towards mitralactonine, pipecolic acid and piperidine alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2013. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1920.

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4

Archibald, Glenn Philip. "Use of novel nitrones in the synthesis of piperidine alkaloids." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7127.

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The current study focused on development of a flexible synthetic strategy for the enantioselective preparation of 2-substituted-3-hydroxypiperidines utilising chiral 3-hydroxytetrahydropyridine N-oxides. Initial studies into the regio- and stereoselectivity of the 1,3-dipolar cycloaddition reaction between O-benzyl protected 3-hydroxytetrahydropyridine N-oxide 208 and a range of alkenes, proceeded with excellent exo/endo selectivity and near perfect regioselectivity. However the anti/syn selectivity was only moderately in favour of the desired anti-compounds. Further development has led to the

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5

Moore, Rebecca J. "Novel approaches to natural product synthesis using organozinc intermediates." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362516.

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6

Coggins, P. "Syntheses with 2-alkyl-2,3,4,5-tetrahydropyridine-1-oxides." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235969.

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7

Upadhyay, P. K. "Development of new methodology using phosphorus ylides and enantioselective synthesis of pyrrolidine and piperidine alkaloids." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2009. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2768.

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8

Pivatto, Marcos [UNESP]. "Estudo fitoquímico dos frutos de Senna spectabilis e análise comparativa do perfil alcaloídico de S. spectabilis e Cassia leptophylla." Universidade Estadual Paulista (UNESP), 2005. http://hdl.handle.net/11449/97994.

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Made available in DSpace on 2014-06-11T19:29:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2005-12-01Bitstream added on 2014-06-13T19:58:51Z : No. of bitstreams: 1 pivatto_m_me_araiq.pdf: 4500291 bytes, checksum: 41c36cab9b65c53f1fe92528b346a70e (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O presente trabalho objetivou o estudo fitoquímico dos frutos de Senna spectabilis e o estudo comparativo do perfil alcaloídico entre S. spectabilis e Cassia leptophylla, outra espécie vegetal relatada como fonte de alcalóides piperidínicos. O estudo fitoquímico do

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9

Lansakara, Ashabha Indrashika. "Intramolecular cyclizations of alkyl pyridines & alkylidene dihydropyridines as synthetic intermediates toward synthesis of bis(piperidine) alkaloids." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2105.

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Nature provides fascinating and complicated molecular structures which offer synthetic organic chemists amazing opportunities for the design of new strategies for natural product synthesis. Among these, nitrogen containing aza-heterocycles are of unparalleled importance in natural product, bioorganic, and medicinal chemistry. Pyridine and its derivatives in particular are the most common aza-heterocycles encountered in natural products, medicinal and materials chemistry. Pyridine derivatives also serve as precursors to fun

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10

Pivatto, Marcos. "Estudo fitoquímico dos frutos de Senna spectabilis e análise comparativa do perfil alcaloídico de S. spectabilis e Cassia leptophylla /." Araraquara : [s.n.], 2005. http://hdl.handle.net/11449/97994.

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Resumo: O presente trabalho objetivou o estudo fitoquímico dos frutos de Senna spectabilis e o estudo comparativo do perfil alcaloídico entre S. spectabilis e Cassia leptophylla, outra espécie vegetal relatada como fonte de alcalóides piperidínicos. O estudo fitoquímico dos frutos de S. spectabilis forneceu 4 alcalóides piperidínicos: cassina (1), 3-O-acetil-cassina (20), 3-O-feruloil-cassina (18) e um estereoisômero da cassina (19), cujas configurações, ralativa e absoluta, ainda não foram determinadas. Dentre estes, somente a cassina (1) já era conhecida e foi isolada, em nosso grupo de pesq

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11

Dall'Aglio-Holvercem, Christiane Gonçalves. "Estudos populacionais e taxonomicos de formigas lava-pes, Solenopsis invicta (Hymenoptera: Formicidae) e da fenologia de seus parasitoides do genero Pseudacteon (Diptera: Phoridae)." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316308.

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Orientadores: Woodruff Whitman Benson, Jose Roberto Trigo<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-06T14:03:47Z (GMT). No. of bitstreams: 1 Dall'Aglio-Holvercem_ChristianeGoncalves_D.pdf: 1459643 bytes, checksum: 5ed521529fb7303e231df7d9f2ebbda3 (MD5) Previous issue date: 2006<br>Resumo: Este trabalho discute alguns aspectos da ecologia da formiga lava-pés Solenopsis invicta e seus parasitóides, as moscas do gênero Pseudacteon (familia Phoridae), e da taxonomia de S. invicta e S. saevissima, ambas nativas da América

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12

Pivatto, Marcos. "Espectrometria de massas aplicada aos estudos de biossíntese de alcalóides de Senna spectabilis /." Araraquara : [s.n.], 2010. http://hdl.handle.net/11449/105776.

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Resumo: O presente trabalho teve como objetivo o estudo das vias biossintéticas dos alcalóides piperidínicos presentes em Senna spectabilis, motivado pela potente atividade anticolinesterásica e baixa toxicidade observada no derivado (-)-3-O-acetil-espectalina (15), eleito como composto líder para o desenvolvimento de fármacos anti-Alzheimer que estão em fase de estudos pré-clínicos. Por outro lado, o interesse acadêmico no conhecimento das vias metabólicas, pode levar a estudos futuros de engenharia genética para potencializar a produção desses metabólitos uma vez que a síntese é extremamente

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13

Pivatto, Marcos [UNESP]. "Espectrometria de massas aplicada aos estudos de biossíntese de alcalóides de Senna spectabilis." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/105776.

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Made available in DSpace on 2014-06-11T19:35:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-23Bitstream added on 2014-06-13T18:46:23Z : No. of bitstreams: 1 pivatto_m_dr_araiq.pdf: 3895401 bytes, checksum: 8f00934510e296fa101a80060a9db12a (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>O presente trabalho teve como objetivo o estudo das vias biossintéticas dos alcalóides piperidínicos presentes em Senna spectabilis, motivado pela potente atividade anticolinesterásica e baixa toxicid

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14

Eriksson, Carina. "Isolation, Synthesis and Structure-Activity Relationships of Antifeedants against the Pine Weevil, Hylobius Abietis." Doctoral thesis, Stockholm Chemical Science and Engineering, KTH, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3919.

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15

Rosset, Isac George. "Diazocetonas α,β-insaturadas como reagentes multifuncionais: aplicação na síntese de alcaloides piperidínicos e pirrolidínicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-20052015-101409/.

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p>O primeira parte do trabalho descreve a preparação de um novo reagente de olefinação de HWE para o preparo de diazocetonas α, β-insaturadas com geometria Z e aplicação na síntese de núcleos piperidínicos funcionalizados. Através da otimização da reação de HWE empregando o benzaldeído como aldeído padrão foi possível maximizar a obtenção do isômero Z desejado (92%, Z:E 9:1). As reações-chave para a formação dos núcleos piperidínicos foram a de olefinação de HWE utilizando amino-aldeídos, obtendo-se bons rendimentos e boa seletividade, seguida de uma reação de inserção N-H catalisad

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16

Smith, Peter Duncan. "Synthesis of pipecolic acid derivatives via aza-Diels-Alder reactions." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/552.

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17

Vu, Van Ha. "Cyanation anodique et réaction de Fry modifiée : application à la synthèse stéréosélective d’alcaloïdes de la pipéridine." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S138/document.

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Les alcaloïdes de la pipéridine sont des composés présents à la fois dans le règne animal et végétal. L'approche générale que nous avons développée au cours de ce travail de thèse est basée sur l'utilisation de différents -aminonitriles qui ont été préparés soit par réduction de sels de pyridinium chiraux soit par cyanation anodique d'amines tertiaires dérivées de l'-phényl-éthylamine. Dans le premier cas, la modification de la réaction de Fry nous a permis de préparer les deux énantiomères de la coniine qui constitue l'agent toxique de la grande cigüe (Conium maculatum). En combinant cette mé

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18

Díez, Pascual Anna. "Aplicacions sintètiques de les 2-aril-4-piperidones: una nova síntesi de benzo(a)- i indolo(2 3-a)quinolizidin-2-ones." Doctoral thesis, Universitat de Barcelona, 1987. http://hdl.handle.net/10803/672973.

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L'objectiu fonamental de la present tesi ha consistit en desenvolupar un mètode alternatiu per a la síntesi d'alcaloides amb nucli de benzo|a|- i d'indolo-|2,3-a|quinolizidin-2-ona que comporti el tancament dels anells B i C respectivament a partir d'una 2-arilpiperidina per integració sobre el nitrogen piperidínic, dels dos àtoms de carboni que formaran la cadena d'ariletilamina i posterior ciclació electròfila sobre l'anell aromàtic.

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19

Borhade, R. G. "Sugar nitrone based approaches for the total synthesis of biologically active polyhydroxylated pyrrolidine and piperidine alkaloides, studies towards the synthesis of leustroducsin-B and some Pd mediated reactions on sugar alkynes." Thesis(Ph.D.), CSIR-National Chemical Laboratory, Pune, 2007. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/2575.

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20

Geant, Pierre-Yves. "Synthèse d'aminoalcools assistée par un sulfoxyde chiral." Thesis, Montpellier 2, 2011. http://www.theses.fr/2011MON20169/document.

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Les travaux présentés dans ce mémoire décrivent une nouvelle voie de synthèse d'aminoalcools 1,2 à partir de γ-bromo-β-cétosulfoxydes, dans lesquels seul le centre stéréogène du soufre est défini. Cette synthèse s'appuie sur deux processus hautement stéréocontrôlés dirigés par le groupement sulfoxyde : le dédoublement cinétique dynamique lors de la substitution nucléophile du brome par la dibenzylamine et la réduction diastéréosélective du carbonyle. Les syn-γ-N,N-dibenzylamino-β-hydroxysulfoxydes correspondants ont été obtenus avec des excès diastéréoisomériques supérieurs à 95%. Les syn-γ-N,

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21

Vilca, Edson Emilio Garambel. "Síntese de um intermediário indólico-piperidínico, visando a síntese total do ácido lisérgico." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-09022015-165711/.

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Os alcalóides ergolínicos são uma categoria de compostos que possuem um esqueleto tetracíclico [6,5,6,6] derivados da ergolina. Do ponto de vista farmacológico, estes compostos são uma classe de produtos naturais importantes, já que exibem uma grande variedade de atividade biológica. Estas moléculas têm sido alvos sintéticos devido ao seu complexo esqueleto tetracíclico e as propriedades supracitadas, o que resultou no desenvolvimento de sínteses totais ao longo do tempo. O ácido lisérgico é o representante notável da família dos alcaloides ergolínicos, uma vez que desde o ano de 1956 até 2013

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22

Ahamada, Kadiria. "Stratégies biomimétiques en vue de la synthèse totale de deux substances naturelles polycycliques complexes : la bipléiophylline et l'haliclonine A." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114807/document.

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Les travaux présentés concernent dans une première partie la synthèse biomimétique d’un alcaloïde indolomonoterpénique : la bipléiophylline. La bipléiophylline est le résultat de l’assemblage complexe de deux unités indoliques identiques ancrées sur une plateforme aromatique. Une stratégie générale de synthèse biomimétique de la bipléiophylline consistant i) à la synthèse de l’unité indolique pléiocarpamine et ii) à l’oxydation de l’acide 2,3-dihydroxybenzoïque a été envisagée. L’accès au squelette complexe de la pléiocarpamine a été étudié selon plusieurs stratégies de synthèse totale mais ég

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23

Greyling, Hendrik Frederik. "Die sintese van alkaloiedagtige glikosidase-inhibeerders vanuit monosakkariede." Thesis, 2014. http://hdl.handle.net/10210/10917.

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M.Sc. (Chemistry)<br>The aim of this study was to investigate alternative routes for the stereocontrolled synthesis of hydroxylated indolizidine, piperidine and pyrrolidine alkaloids, starting from monosaccharides as chiral building blocks. This study was not aimed at improving consisting routes - it was rather aimed at developing new routes towards the synthesis of these alkaloids. Mixed results were obtained in the investigation into alternative routes for the synthesis of the bicyclic poly hydroxylated indolizidine alkaloids, but a new and efficient stereospecific synthesis of polyhydroxyla

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24

Yao-Ting, Yeh, and 葉耀廷. "Chiral Cyclic Nitrone Chemistry: Preparation of Polyhydroxylated Pyrrolidine and Piperidine Alkaloids." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/61660957671733400891.

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碩士<br>國立臺灣師範大學<br>化學系<br>96<br>The chiral polyhydroxy alkaloids have attracted considerable attention in organic synthesis owing to their remarkable biological properties and their potential as pharmaceuticals, especially, to serve as glycosidase inhibitors in treatment of cancers, diabetes and viral infections. The development of new methods for the synthesis of pyrrolidine- or piperidine-based compounds is therefore of considerable importance, particularly for the approaches leading to chiral derivatives of these ring skeletons. In this thesis, we have developed new and efficient synthet

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25

McLachlan, Matthew M. W. "Studies directed toward the synthesis of the Galbulimima belgraveana alkaloids." Phd thesis, 2002. http://hdl.handle.net/1885/148524.

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26

LIN, ZHI-HUA, and 林志華. "Application of TiCl4 induced iminium ion cyclizations to the preparations of piperidine alkaloids." Thesis, 1990. http://ndltd.ncl.edu.tw/handle/95936694406267723692.

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27

Khandare, Sopan Pralhad. "Total Synthesis of Piperidine and Pyrrolidine Alkaloids and Towards the Total Synthesis of Strychnine." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5817.

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Total synthesis of natural products is an important area of contemporary interest in synthetic organic chemistry. Total synthesis of natural products serves as a platform for the development of new synthetic strategies and for improving the existing synthetic methods. Chiral sulfinimines are excellent substrates for the synthesis of amine-containing compounds. The ability of sulfinimines in rendering the product amines with consistent high selectivity has made these reagents one of the most used reagents in organic synthesis. The thesis describes the investigations concerning the a

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28

Kao, Chien-Lun, and 高健倫. "Syntheses of piperidine alkaloid (–)-pelletierine, (–)-homopipecolic acid and indole alkaloid physostigmine." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/65876183771515378943.

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碩士<br>國立中興大學<br>化學系所<br>100<br>Piperidine and indole alkaloids are medicinal compounds with potent biological activity activities. Here described syntheses of (–)-piperidine alkaloids (–)-pelletierine and (–)-homopipecolic acid, featuring a Bayer-Villiger oxidation of 6-tropanone as the key step; and synthetic studies on physostigmine and esermethole as applications of the Rh-catalyzed hydroformylation / double cyclization reaction.

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29

Huang, Jhih-Liang, and 黃智莨. "Synthesis of Bicyclic Piperidines and Alkaloids by Intramolecular Aza-Michael Reactions." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/74034591150379173577.

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博士<br>輔仁大學<br>化學系<br>101<br>This thesis used the cross metathesis of C ‐ 6 substituted 4-phenylthio-5,6-dihydro-2-pyridones (3) with methyl acrylate to synthesize compounds 51. Further treatment with Bu3SnH/AIBN led to the detosylation compounds 52. The bicyclic piperidines 53 could be obtained by intramolecular aza-Michael reaction of compounds 52 under basic conditions. We also studied the diastereoselectivity of the cyclization reaction. Reduction of the ester group of compound 53a (cis/trans 1:1) by treatment with LiAlH4 at low temperature afforded compounds cis-63 and trans-63. Brominat

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30

Chen, Hao-Yu, and 陳皓俞. "Studies on Syntheses of Chiral 2,6-Disubstituted Piperidines and 5-Substituted Indolizidines: Applications on Total Syntheses of Dendrobatid Alkaloids (+)-167B and (+)-209D." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/61634966772935321531.

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碩士<br>國立中興大學<br>化學系所<br>103<br>Indolizidine and quinolizidine alkaloids are medicinal compounds with potent biological activities. Here we present total syntheses of indolizidine (+)-167B and (+)-209D, featuring our developed preparation of enantiomerical tropanol derivatives, followed by functional transformations to 2,6-disubstituted piperidine derivatives. Applications to Lasubines and Sparteine will be included.

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