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1

Virjamo, V., and R. Julkunen-Tiitto. "Variation in piperidine alkaloid chemistry of Norway spruce (Picea abies) foliage in diverse geographic origins grown in the same area." Canadian Journal of Forest Research 46, no. 4 (2016): 456–60. http://dx.doi.org/10.1139/cjfr-2015-0388.

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Volatile piperidine alkaloids are widespread compounds found in low amounts in coniferous species. Here, we investigated the variation of piperidine alkaloid chemistry of Norway spruce (Picea abies (L.) Karst.) in a provenance-type experiment. Volatile piperidine alkaloids were analysed from current-year mature needles of 12 geographical origins grown for 35 years at the same site. Results indicate that, despite long-lasting similar growth conditions, origins were still showing different alkaloid composition and concentrations, indicating solid genotype variation. The highest total piperidine
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2

Tilve, Santosh, Sandesh Bugde, and Prajesh S.Volvoikar. "Protecting-Group-Directed Regio- and Stereoselective Oxymercuration–Demercuration: Synthesis of Piperidine Alkaloids Containing 1,2- and 1,3-Amino Alcohol Units." Synthesis 50, no. 05 (2017): 1113–22. http://dx.doi.org/10.1055/s-0036-1589523.

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An efficient synthesis of naturally occurring 1,2- and 1,3-amino alcohol unit containing 2-substituted piperidine alkaloids and their analogues has been developed from l-pipecolinic acid. The protocol describes the regio- and stereoselective oxymercuration–demercuration of 2-alkenyl piperidines based on protecting groups to give piperidine alkaloids as a key step.
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3

Poulsen, Thomas B., and Gustav J. Wørmer. "The [4.3.0] Piperidine Alkaloids: Architectures, Biology, Biosyntheses, and the Complete Details of the Asymmetric Syntheses of Streptazone A and Abikoviromycin." Synlett 33, no. 07 (2021): 637–54. http://dx.doi.org/10.1055/a-1688-0826.

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AbstractPiperidine alkaloids continue to challenge the synthetic community by featuring densely functionalized scaffolds that often require careful chemical orchestration. Streptazone A and abikoviromycin are small and highly functionalized piperidine alkaloids, both accommodating Michael acceptors and a labile epoxide. These moieties are loaded into a [4.3.0] bicyclic core also present in other structurally related natural products, including the well-known piperidine alkaloid streptazolin. Here, we cover ring-closing strategies employed in earlier streptazolin syntheses; provide a concise ov
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4

Enders, Dieter, and Christoph Thiebes. "Efficient stereoselective syntheses of piperidine, pyrrolidine, and indolizidine alkaloids." Pure and Applied Chemistry 73, no. 3 (2001): 573–78. http://dx.doi.org/10.1351/pac200173030573.

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Recent advances in the diastereo- and enantioselective synthesis of piperidine, pyrrolidine, and indolizidine alkaloids, based on the highly stereoselective 1,2-addition to the CN double bond of chiral aldehyde-SAMP/RAMP hydrazones, are described. The enantioselective syntheses of the pyrrolidine alkaloids bgugaine and (2S,12¢R)-2-(12¢-aminotridecyl)-pyrrolidine, a defense alkaloid of the Mexican bean beetle are reported. Furthermore, the SAMP/RAMP-hydrazone method was applied to the syntheses of two 5,8-disubstituted indolizidine alkaloids that have been extracted from neotropical poison-dart
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5

Frolov, Nikita A., and Anatoly N. Vereshchagin. "Piperidine Derivatives: Recent Advances in Synthesis and Pharmacological Applications." International Journal of Molecular Sciences 24, no. 3 (2023): 2937. http://dx.doi.org/10.3390/ijms24032937.

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Piperidines are among the most important synthetic fragments for designing drugs and play a significant role in the pharmaceutical industry. Their derivatives are present in more than twenty classes of pharmaceuticals, as well as alkaloids. The current review summarizes recent scientific literature on intra- and intermolecular reactions leading to the formation of various piperidine derivatives: substituted piperidines, spiropiperidines, condensed piperidines, and piperidinones. Moreover, the pharmaceutical applications of synthetic and natural piperidines were covered, as well as the latest s
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6

Putri, Ayu Darma, and Icha Putri Winata. "Pengaruh Pemberian Ekstrak Spirulina terhadap Antikanker." Jurnal Penelitian Perawat Profesional 1, no. 1 (2019): 103–8. http://dx.doi.org/10.37287/jppp.v1i1.27.

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Spirulina adalah cyanobacterium mikroskopik berfilamen, mengandung bahan yang bermanfaat bagi manusia antara lain alkaloid, flavonoid, steroid, saponin, dan senyawa aktif piperidinone, piperidine, hexadecanenitrile yang merupakan zat dengan aktivitas kemopreventif kanker yang poten. Zat ini mampu menginduksi apoptosis dengan menimbulkan fragmentasi DNA dan kondensasi nucleus dan juga memiliki kemampuan untuk menurunkan regulasi protein anti apoptosis dan meningkatkan regulasi protein proapoptosi. Tujuan literature review ini untuk mengetahui efek ekstrak spirulina terhadap antikanker. Penulisa
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7

Bonandi, Elisa, Giada Tedesco, Dario Perdicchia, and Daniele Passarella. "Total Synthesis of (–)-Anaferine: A Further Ramification in a Diversity-Oriented Approach." Molecules 25, no. 5 (2020): 1057. http://dx.doi.org/10.3390/molecules25051057.

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The piperidine ring is a widespread motif in several natural bioactive alkaloids of both vegetal and marine origin. In the last years, a diversity-oriented synthetic (DOS) approach, aimed at the generation of a library of piperidine-based derivatives, was developed in our research group, employing commercially available 2-piperidine ethanol as a versatile precursor. Here, we report the exploration of another ramification of our DOS approach, that led us to the stereoselective total synthesis of (–)-anaferine, a bis-piperidine alkaloid present in Withania somnifera extract. This natural product
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8

Miguel, Obdulio G., Adair R. S. Santos, João B. Calixto, Franco Delle Monache, and Rosendo A. Yunes. "Antinociceptive Activity of the Natural Piperidine Alkaloid Hydrochlorides from Syphocampylus verticellatus." Zeitschrift für Naturforschung C 57, no. 1-2 (2002): 81–84. http://dx.doi.org/10.1515/znc-2002-1-214.

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In addition to 3′-methoxyluteolin and mixtures of sterols and triterpenes, the leaves of Syphocampylus Verticellatus yielded two piperidine alkaloid hydrochlorides, one of them has a novel structure. The alkaloids exhibit antinociceptive activity.
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9

Samoylenko, Volodymyr, D. Chuck Dunbar, Melissa R. Jacob, Vaishali C. Joshi, Mohammad K. Ashfaq, and Ilias Muhammad. "Two New Alkylated Piperidine Alkaloids from Western Honey Mesquite: Prosopis glandulosa Torr. var. torreyana." Natural Product Communications 3, no. 1 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300108.

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Prosopis glandulosa Torr. var. torreyana (L. Benson) M. C. Johnston root bark, collected in Texas, yielded two new alkylated piperidine alkaloids, namely 3-isocassine (1) and N-methyl-3-isocassine (2), together with the previously reported N-methylcassine (3). In addition, the alkylated piperidinyl indolizidine alkaloid juliprosopine (4) was isolated from the leaves of the same plant. The structures and stereochemistry of compounds 1–4 were determined from 1D and 2D NMR data, including COSY, HMQC, HMBC and NOESY experiments, and ESI-HRMS. Juliprosopine (4) demonstrated antimicrobial activities
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10

Guzmán-Rodríguez, Sergio, Jesús Chávez-Reyes, Priscila Vázquez-León, et al. "1-Boc-Piperidine-4-Carboxaldehyde Prevents Binge-Eating Behaviour and Anxiety in Rats." Pharmacology 106, no. 5-6 (2021): 305–15. http://dx.doi.org/10.1159/000513376.

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<b><i>Background:</i></b> Piperidines are biogenic amines studied mainly in toxicology because they were initially found as alkaloids from peppers and insect venoms. Piperidines are also produced in the human body, and their actions seem to be related to wakefulness/sleep and other cognitive phenomena. Piperidines have been minimally characterized for therapeutic applications. In this context, 1-Boc-piperidine-4-carboxaldehyde (1-Boc-piperidine) is a piperidine-derivative molecule with no mechanism of action reported, although its uses include the synthesis of GPR119 se
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11

Sośnicki, Jacek G., and Tomasz J. Idzik. "Pyridones – Powerful Precursors for the Synthesis of Alkaloids, Their Derivatives, and Alkaloid-Inspired Compounds." Synthesis 51, no. 18 (2019): 3369–96. http://dx.doi.org/10.1055/s-0037-1611844.

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2-Pyridone is characterized by a very wide range of reactivity of a different nature, ranging from electrophilic aromatic substitution, CH–metal-mediated reactions, and NH/OH functionalization of both possible lactam/lactim tautomers, through cycloaddition, to nucleophilic addition and transformation of the tautomeric C=O/C–OH moiety. The high availability of 2-pyridones and the possibility of their far-reaching functionalization additionally increased their values. Therefore, they are very useful building blocks for the synthesis of structurally diverse piperidine and pyridine compounds, incl
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12

ISMAIL, ZURIAH, and AZIZ AHMAD. "PHARMACOLOGICAL PROPERTIES OF POLYHYDROXY ALKALOIDS: A MINI-REVIEW." JOURNAL OF SUSTAINABILITY SCIENCE AND MANAGEMENT 19, no. 12 (2024): 155–67. https://doi.org/10.46754/jssm.2024.12.010.

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Alkaloids are nitrogenous compounds within heterocyclic rings grouped into pyrrolidine, piperidine, pyrrolizidine, indolizidine, and nor-tropane alkaloids. Nevertheless, the origin and biological properties of polyhydroxy alkaloids remain limited. Therefore, this article aims to review polyhydroxy alkaloid’ major source and pharmacological properties. Based on the literature, the major source of polyhydroxy alkaloids primarily originate from various plant families including Asteraceae, Araceae, Boraginaceae, Fabaceae, Convolvulaceae, Lamiaceae, Orchidaceae, Piperaceae, Poaceae, and Solanaceae.
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13

Qasem, Ashraf M. A., Michael G. Rowan, and Ian S. Blagbrough. "Poisonous Piperidine Plants and the Biodiversity of Norditerpenoid Alkaloids for Leads in Drug Discovery: Experimental Aspects." International Journal of Molecular Sciences 23, no. 20 (2022): 12128. http://dx.doi.org/10.3390/ijms232012128.

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There are famous examples of simple (e.g., hemlock, Conium maculatum L.) and complex (e.g., opium poppy, Papaver somniferum L., Papaveraceae) piperidine-alkaloid-containing plants. Many of these are highly poisonous, whilst pepper is well-known gastronomically, and several substituted piperidine alkaloids are therapeutically beneficial as a function of dose and mode of action. This review covers the taxonomy of the genera Aconitum, Delphinium, and the controversial Consolida. As part of studying the biodiversity of norditerpenoid alkaloids (NDAS), the majority of which possess an N-ethyl group
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14

Pinder, A. R. "Pyrrlidine, piperidine, and pyridine alkaloids." Natural Product Reports 2, no. 2 (1985): 181. http://dx.doi.org/10.1039/np9850200181.

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15

Pinder, A. R. "Pyrrolidine, piperidine, and pyridine alkaloids." Natural Product Reports 3 (1986): 171. http://dx.doi.org/10.1039/np9860300171.

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16

Pinder, A. R. "Pyrrolidine, piperidine, and pyridine alkaloids." Natural Product Reports 4 (1987): 527. http://dx.doi.org/10.1039/np9870400527.

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17

Pinder, A. R. "Pyrrolidine, piperidine, and pyridine alkaloids." Natural Product Reports 6, no. 5 (1989): 515. http://dx.doi.org/10.1039/np9890600515.

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18

Pinder, A. R. "Pyrrolidine, piperidine, and pyridine alkaloids." Natural Product Reports 7, no. 5 (1990): 447. http://dx.doi.org/10.1039/np9900700447.

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19

Dragull, Klaus, Wesley Y. Yoshida, and Chung-Shih Tang. "Piperidine alkaloids from Piper methysticum." Phytochemistry 63, no. 2 (2003): 193–98. http://dx.doi.org/10.1016/s0031-9422(03)00111-0.

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20

Huang, Wenjie, Xiaomin Yi, Jianying Feng, Yihai Wang, and Xiangjiu He. "Piperidine alkaloids from Alocasia macrorrhiza." Phytochemistry 143 (November 2017): 81–86. http://dx.doi.org/10.1016/j.phytochem.2017.07.012.

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21

Nash, R., J. Beaumont, N. Veitch, et al. "Phenylethylamine and Piperidine Alkaloids inAloeSpecies." Planta Medica 58, no. 01 (1992): 84–87. http://dx.doi.org/10.1055/s-2006-961396.

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22

Jagtap, Shital, and Poonam Kaswan. "Synthesis and Antimicrobial Activity of Novel Sulfonyl Piperidine Carboxamide Derivatives Prepared from N-Boc-Piperidine-3-carboxylic Acid via Amide Coupling." Asian Journal of Chemistry 37, no. 6 (2025): 1315–21. https://doi.org/10.14233/ajchem.2025.33717.

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Piperidines serve as pivotal synthetic building blocks in the realm of drug design, with their derivatives forming essential parts of a wide range of drugs and alkaloids. This study presents a novel approach involving sulfonyl derivatives of piperidine-3-carboxylic acid, achieved through amide coupling with substituted sulphonyl chlorides. The synthesized compounds underwent characterization via IR, 1H NMR, 13C NMR and MS analyses. Specifically, a series of novel sulphonamides derived from 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid was synthesized, given the significance of sulphonami
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23

Durant, Alex, and Claude Hootelé. "Sedum alkaloids XII. Synthesis of the new piperidine alkaloids homosedinone and dihomosedinone." Canadian Journal of Chemistry 70, no. 11 (1992): 2722–25. http://dx.doi.org/10.1139/v92-345.

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The new piperidine alkaloids homosedinone 2 and dihomosedinone 3, isolated from Sedumacre, have been synthesized from (−)-norsedamine 7 by application of the sequence: anodic methoxylation – elimination – nucleophilic addition.
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24

Amat, Mercedes, Núria Llor, Rosa Griera, Maria Pérez, and Joan Bosch. "Enantioselective Synthesis of Alkaloids from Phenylglycinol-Derived Lactams." Natural Product Communications 6, no. 4 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600412.

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This review is focused on recent synthetic achievements and ongoing work in our laboratory using phenylglycinol-derived oxazolopiperidone lactams as starting materials for the enantioselective synthesis of piperidine-containing alkaloids: madangamines, 2,5-disubstituted decahydroquinoline and 1-substituted tetrahydroisoquinoline alkaloids, the indole alkaloids 20 S- and 20 R-dihydrocleavamine and quebrachamine, and indole alkaloids of the uleine and silicine groups.
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25

Liu, Hai-Li, Xiao-Yin Huang, Mei-Ling Dong, Guo-Rong Xin, and Yue-Wei Guo. "Piperidine Alkaloids from Chinese MangroveSonneratia hainanensis." Planta Medica 76, no. 09 (2010): 920–22. http://dx.doi.org/10.1055/s-0029-1240811.

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26

Biavatti, Maique W., Richard T. Brown, and Cid AimbiréM Santos. "Two piperidine alkaloids from Siphocampylus verticillatus." Phytochemistry 48, no. 4 (1998): 747–49. http://dx.doi.org/10.1016/s0031-9422(98)00082-x.

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27

Jong-Woong, Ahn, Ahn Mi-Ja, Zee Ok-Pyo, et al. "Piperidine alkaloids from Piper retrofractum fruits." Phytochemistry 31, no. 10 (1992): 3609–12. http://dx.doi.org/10.1016/0031-9422(92)83736-i.

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28

Plunkett, Owen, and Malcolm Sainsbury. "ChemInform Abstract: Pyridine and Piperidine Alkaloids." ChemInform 31, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.200011273.

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29

Taday, Freya, Ryan Cairns, Adam O’Connell, and Elaine O’Reilly. "Combining bio- and organocatalysis for the synthesis of piperidine alkaloids." Chemical Communications 58, no. 11 (2022): 1697–700. http://dx.doi.org/10.1039/d1cc03865f.

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30

Yadav, Nagendra Nath, Jihye Choi, and Hyun-Joon Ha. "One-pot multiple reactions: asymmetric synthesis of 2,6-cis-disubstituted piperidine alkaloids from chiral aziridine." Organic & Biomolecular Chemistry 14, no. 27 (2016): 6426–34. http://dx.doi.org/10.1039/c6ob00806b.

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31

Symma, Nico, Marek Bütergerds, Jandirk Sendker, et al. "Novel Piperidine and 3,4-dihydro-2H-pyrrole Alkaloids from Tilia platyphyllos and Tilia cordata Flowers." Planta Medica 87, no. 09 (2021): 686–700. http://dx.doi.org/10.1055/a-1340-0099.

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AbstractLime flowers, traditionally used for medical purposes for the treatment of symptoms of the common cold and mental stress, consist of the dried inflorescences including the floral bracts of Tilia cordata, Tilia platyphyllos, Tilia × vulgaris, or mixtures thereof. During phytochemical investigations, 6 different alkaloids – not described until now – were detected in T. cordata and T. platyphyllos flowers. They have been isolated and characterized as alkaloids with a dihydro-pyrrole and a piperidine substructure, respectively. Compounds 1a and 1b (tiliines A and B) are characterized as 2
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32

Driessens, Frank, and ClaUDE Hootelé. "Sedum alkaloids. XI. Synthesis of sedinone and sedacrine by application of anodic oxidation." Canadian Journal of Chemistry 69, no. 2 (1991): 211–17. http://dx.doi.org/10.1139/v91-034.

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α-Methoxycarbamate 12, synthetic precursor of the 2,6-disubstituted alkaloids of Sedum acre, was obtained in high yield from 2-phenacylpiperidine 5; the key step of the synthesis rests on the anodic methoxylation, which allows the functionalization of carbon 6. Nucleophilic substitution of the methoxy group by an acetonyl chain leads, after the required transformations, to sedinone 23. Bromomethoxylation of the enecarbamate 19 followed by dehydrohalogenation and nucleophilic substitution of the methoxy group leads to sedacrine 33. In both cases, the nucleophilic substitution of the methoxy gro
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33

Srivastava, Nikhil, Lingamurthy Macha, and Hyun-Joon Ha. "Stereoselective synthesis of 2,6-disubstituted piperidine alkaloids." Organic & Biomolecular Chemistry 18, no. 29 (2020): 5493–512. http://dx.doi.org/10.1039/d0ob00918k.

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The synthetic methods to build the 2,6-disubstituted piperidine structural motif were described focusing on stereochemical control of two substituents at C2 and C6 with specific examples of natural products.
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34

Kamarul, Zaman Munirah Adibah, and Azzeme Azzreena Mohamad. "Plant toxins: alkaloids and their toxicities." GSC Biological and Pharmaceutical Sciences 6, no. 2 (2019): 021–29. https://doi.org/10.5281/zenodo.4303843.

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Since ancient civilization, plants have been utilized in many aspects of life, especially in medicinal purposes due to the presence of distinctive secondary metabolites like alkaloids, phenolics and terpenoids. Among them, alkaloids represent a large group of secondary metabolites that have basic properties and comprise nitrogen atom within the heterocyclic ring. Plant synthesizes alkaloids to maintain their survivability under unfavorable conditions. Over 3000 years, indigenous people have been used alkaloid-containing plant extracts to treat several ailments such as fever, snakebite and insa
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35

Mgbeahuruike, Eunice, Pia Fyhrquist, Heikki Vuorela, Riitta Julkunen-Tiitto, and Yvonne Holm. "Alkaloid-Rich Crude Extracts, Fractions and Piperamide Alkaloids of Piper guineense Possess Promising Antibacterial Effects." Antibiotics 7, no. 4 (2018): 98. http://dx.doi.org/10.3390/antibiotics7040098.

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Piper guineense is a food and medicinal plant commonly used to treat infectious diseases in West-African traditional medicine. In a bid to identify new antibacterial compounds due to bacterial resistance to antibiotics, twelve extracts of P. guineense fruits and leaves, obtained by sequential extraction, as well as the piperine and piperlongumine commercial compounds were evaluated for antibacterial activity against human pathogenic bacteria. HPLC-DAD and UHPLC/Q-TOF MS analysis were conducted to characterize and identify the compounds present in the extracts with promising antibacterial activ
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36

Denic, Marija, Polina Blagojevic, and Niko Radulovic. "Synthetic approaches to coniine and other 2-alkyl piperidines." Facta universitatis - series: Physics, Chemistry and Technology 11, no. 1 (2013): 1–26. http://dx.doi.org/10.2298/fupct1301001d.

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The first synthesis of coniine, a neurotoxic piperidine alkaloid found in poison hemlock (Conium maculatum L.), was performed back in 1886 by Ladenburg. Since that time, numerous different approaches to the synthesis of this and related alkaloids (2-alkylpiperidines) have been developed. Nowadays, the enantioselective/specific synthesis of coniine is taken as a paradigm of the usefulness of new chiral synthetic methodologies. This review aims to summarize and systematize recent progress in the synthesis of coniine and related compounds.
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37

Plehiers, Mark, та Claude Hootelé. "Synthesis of β-hydroxypiperidine alkaloids by anodic oxidation of carbamates and hydroboration". Canadian Journal of Chemistry 74, № 12 (1996): 2444–53. http://dx.doi.org/10.1139/v96-273.

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The β-hydroxypiperidine alkaloids (±)-pseudoconhydrine, (±)-N-methylpseudoconhydrine, (−)-5-hydroxysedamine, and (+)-sedacryptine were synthesized. Successive functionalization of the piperidine ring via anodic methoxylation allowed the regio- and stereoselective introduction of the substituents. The α and α′ substituents were introduced by application of the sequence elimination–nucleophilic addition from 2- or 2,5-substituted 6-methoxycarbamates. Hydroboration – oxidation of enecarbamates, obtained by elimination of methanol from α-methoxycarbamates, allowed the introduction of the β-hydroxy
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38

Galman, James L., Iustina Slabu, Fabio Parmeggiani, and Nicholas J. Turner. "Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction." Chemical Communications 54, no. 80 (2018): 11316–19. http://dx.doi.org/10.1039/c8cc06759g.

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39

Pinder, A. R. "Pyrrole, pyrrolidine, piperidine, pyridine, and azepine alkaloids." Natural Product Reports 6, no. 1 (1989): 67. http://dx.doi.org/10.1039/np9890600067.

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40

Taber, Douglass F., and Peter W. DeMatteo. "A Piperidine Chiron for the Veratrum Alkaloids." Journal of Organic Chemistry 77, no. 9 (2012): 4235–41. http://dx.doi.org/10.1021/jo2026228.

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41

Kesting, Julie R., Inge-Lise Tolderlund, Anders F. Pedersen, Matthias Witt, Jerzy W. Jaroszewski, and Dan Staerk. "Piperidine and Tetrahydropyridine Alkaloids fromLobelia siphiliticaandHippobroma longiflora." Journal of Natural Products 72, no. 2 (2009): 312–15. http://dx.doi.org/10.1021/np800743w.

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42

Pinder, A. R. "Pyrrole, pyrrolidine, piperidine, pyridine, and azepine alkaloids." Natural Product Reports 9, no. 1 (1992): 17. http://dx.doi.org/10.1039/np9920900017.

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43

Pinder, A. R. "Azetidine, pyrrole, pyrrolidine, piperidine, and pyridine alkaloids." Natural Product Reports 9, no. 5 (1992): 491. http://dx.doi.org/10.1039/np9920900491.

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44

Plunkett, A. O. "Pyrrole, pyrrolidine, pyridine, piperidine, and azepine alkaloids." Natural Product Reports 11, no. 6 (1994): 581. http://dx.doi.org/10.1039/np9941100581.

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45

Liu, Qian-Feng, Ji-Dong Wang, Xiang-Jing Wang, et al. "Two new piperidine alkaloids fromStreptomycessp. NEAU-Z4." Journal of Asian Natural Products Research 15, no. 3 (2013): 221–24. http://dx.doi.org/10.1080/10286020.2012.761209.

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46

Green, Benedict T., Stephen T. Lee, Kip E. Panter, and David R. Brown. "Piperidine alkaloids: Human and food animal teratogens." Food and Chemical Toxicology 50, no. 6 (2012): 2049–55. http://dx.doi.org/10.1016/j.fct.2012.03.049.

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47

Meth-Cohn, Otto, Cze Chak Yau, and Chu-Yi Yu. "New synthetic methodologyen routeto asymmetric piperidine alkaloids." Journal of Heterocyclic Chemistry 36, no. 6 (1999): 1549–53. http://dx.doi.org/10.1002/jhet.5570360615.

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48

Adriaenssens, Louis V., Carolyn A. Austin, Mairi Gibson, David Smith, and Richard C. Hartley. "Stereodivergent Diversity Oriented Synthesis of Piperidine Alkaloids." European Journal of Organic Chemistry 2006, no. 22 (2006): 4998–5001. http://dx.doi.org/10.1002/ejoc.200600744.

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49

CHEN, Hui, and Haji Akber AISA. "NINE NEW PIPERIDINE ALKALOIDS FROM ANACYCLUS PYRETHRUM." Journal of Research in Pharmacy 27_special_issue_7, no. 27_special_issue_7 (2023): 96. http://dx.doi.org/10.29228/jrp.653.

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50

Suciati, Erlinda R. Laili, Wiwied Ekasari, Kuatman, Nitra Nuengchamnong, and Nungruthai Suphrom. "Chemical Profiles and In Vitro Cholinesterase Inhibitory Activities of the Flower Extracts of Cassia spectabilis." Advances in Pharmacological and Pharmaceutical Sciences 2023 (February 28, 2023): 1–9. http://dx.doi.org/10.1155/2023/6066601.

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Abstract:
Background. Cassia spectabilis is a flowering plant containing various metabolites that provide potential for pharmacological activities. The current study aimed to investigate the ethanolic and water extracts of C. spectabilis as cholinesterase inhibitor as one of the target treatments for Alzheimer’s disease. The chemical composition of the extracts was also studied to determine which components are responsible for the bioactivity. Methods. The cholinesterase inhibitory activity assay was carried out by the modified Ellman’s method against acetylcholinesterase (AChE) and butyrylcholinesteras
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