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Journal articles on the topic 'Piperidine and morpholine'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Khamitova, A. E., and D. A. Berillo. "Overview of Piperidine and Morpholine Derivatives as Promising Sources of Biologically Active Compounds (Review)." Drug development & registration 12, no. 2 (2023): 44–54. http://dx.doi.org/10.33380/2305-2066-2023-12-2-44-54.

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Introduction. The search for new, effective and safe pharmacologically active substances remains an urgent task in the field of pharmacy. Many compounds of the piperidine and morpholine series are widely used in medical practice and belong to an important group of biologically active compounds. An informational, literature search on the synthesis of new derivatives of piperidine and morpholine was carried out. The article summarizes the results of studies of new derivatives of piperidine and morpholine as potential sources of biologically active substances.Text. The review is devoted to the re

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2

Petrov, Oleg A., and Irina N. Sadovskaya. "CATALYTIC ACTION OF NITROGEN-CONTAINING BASES ON KINETICS OF ZINC AND HEXA- (m-TRIFLUOROMETHYLPHENYL)BENZOPORPHYRAZINE COMPLEX FORMATION." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 60, no. 3 (2017): 36. http://dx.doi.org/10.6060/tcct.2017603.5543.

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A complexation reaction of hexa(m-trifluoromethylphenyl)benzoporphyrazine with zinc acetate in the system “morpholine (piperidine) – benzene” was studied. Preliminary studies have shown that at concentrations of morpholine and piperidine in benzene less than 0.95 and 0.2 mol/l respectively, the reactions between hexa(m-trifluoromethylphenyl)benzoporphyrazine and zinc acetate not observed. The reaction takes place only at the range of concentrations of morpholine of 0.95 to 8.70 mol /l in benzene and at the range of concentrations of piperidine of 0.2 to 7.74 mol /l in benzene. The changes in t

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3

OLIVEIRA, MAILCAR F., TELMA L. G. LEMOS, MARCOS C. DE MATTOS, TACIANA A. SEGUNDO, GILVANDETE M. P. SANTIAGO, and RAIMUNDO BRAZ-FILHO. "New enamine derivatives of lapachol and biological activity." Anais da Academia Brasileira de Ciências 74, no. 2 (2002): 211–21. http://dx.doi.org/10.1590/s0001-37652002000200004.

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A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A54

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4

P.Badiger, Naveen, and I. M. Khazi. "Synthesis & Evaluation of Antitubercular Activity of Novel Mannich Bases of imidazo[2,1-b][1,3,4]thiadiazoles." Advanced Materials Research 816-817 (September 2013): 1197–201. http://dx.doi.org/10.4028/www.scientific.net/amr.816-817.1197.

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A series of 2-(4-methoxybenzyl)-6-aryl-5-pyrrolidin/piperidin/morpholin-1-ylmethyl-imidazo [2,1-[1,3, thiadiazoles (3a-e, 4a-e & 5a-e) were synthesized by Mannich reaction by condensing 2-(4-methoxybenzyl)-6-arylimidazo [2,1-[1,3,thiadiazoles with pyrrolidine, piperidine and morpholine. The title compounds were screened for antitubercular activity againstMycobacterium tuberculosisH37Rv using the BACTEC 460 radiometric assay. Mannich bases with pyrrolidine substitution were found to be most active antitubercular agents. It proves that as the ring size decreases it becomes much potent in its

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5

Shalaby, ElSayed M., Aisha M. Moustafa, Adel S. Girgis, and Aida M. ElShaabiny. "Crystal Structures of Ethyl 4-(4-Florophenyl)-6-phenyl-2-substituted-3-pyridinecarboxylates." Journal of Crystallography 2014 (May 4, 2014): 1–7. http://dx.doi.org/10.1155/2014/148741.

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Three substituted pyridinecarboxylates were synthesized; (I) ethyl 2-bromo-4-4(fluorophenyl)-6-phenyl-3-pyridinecarboxylate, C20H15BrFNO2, (II) ethyl 4-(4-fluorophenyl)-2-(4-morpholinyl)-6-phenyl-3-pyridinecarboxylate, C24H23FN2O3, and (III) ethyl 4-(4-fluorophenyl)-6-phenyl-2-(1-piperidinyl)-3-pyridinecarboxylate, C25H25FN2O2. It was found that compound (I) belongs to the orthorhombic system with space group P212121, compound (II) to the monoclinic system with space group P21/c, and compound (III) to the monoclinic system with space group C2/c. The morpholine ring in (II) and piperidine ring

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6

Poupin, P., J. J. Godon, E. Zumstein, and N. Truffaut. "Degradation of morpholine, piperidine, and pyrrolidine by mycobacteria: evidences for the involvement of a cytochrome P450." Canadian Journal of Microbiology 45, no. 3 (1999): 209–16. http://dx.doi.org/10.1139/w99-002.

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Nine bacterial strains that grew on morpholine and pyrrolidine as sole carbon, nitrogen, and energy sources were isolated from three different environments with no known morpholine contamination. One of these strains could also degrade piperidine. These bacteria were identified as Mycobacterium strains. A phylogenetic analysis based on the partial 16S rDNA sequences indicated that the isolated strains clustered within the fast growing group of mycobacteria. When the above-mentioned cyclic amines were used as growth substrates, the synthesis of a soluble cytochrome P450 was induced in all these

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7

Modec, Barbara, Nina Podjed, and Nina Lah. "Beyond the Simple Copper(II) Coordination Chemistry with Quinaldinate and Secondary Amines." Molecules 25, no. 7 (2020): 1573. http://dx.doi.org/10.3390/molecules25071573.

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Copper(II) acetate has reacted in methanol with quinaldinic acid (quinoline-2-carboxylic acid) to form [Cu(quin)2(CH3OH)]∙CH3OH (1) (quin− = an anionic form of the acid) with quinaldinates bound in a bidentate chelating manner. In the air, complex 1 gives off methanol and binds water. The conversion was monitored by IR spectroscopy. The aqua complex has shown a facile substitution chemistry with alicyclic secondary amines, pyrrolidine (pyro), and morpholine (morph). trans-[Cu(quin)2(pyro)2] (2) and trans-[Cu(quin)2(morph)2] (4) were obtained in good yields. The morpholine system has produced a

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8

Yadav, Bodke, and S. Sangapure S. "Synthesis and biological activity of some benzofuro[3,2-d]pyrimidines." Journal of Indian Chemical Society Vol. 80, Mar 2003 (2003): 187–89. https://doi.org/10.5281/zenodo.5839259.

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Department of Studies and Research in Chemistry. Gulbarga University, Gulbarga-585 106, India <em>E-mail :</em> bodke___yd@rediffmail.com <em>Manuscript received 21 December 2001 .revised 18 April 2002, accepted 12 December 2002</em> The condensation of ethyl 3-amino-2-benzofuran carboxylate (1) with phenyl isocyanate gave 3-phenylureido-2-benzofuran carboxylate (2), which upon treatment with phosphorus oxychloride gave 2-chloro-3-phenyl-3,4-dihydro-4-oxohenzofnro[3,2-<em>d</em>]pyrimidine (4). The reaction of 4 with alicyclic amines like piperidine and morpholine yielded 2-piperidino/mor

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9

Parkin, Andrew, Iain D. H. Oswald, and Simon Parsons. "Structures of piperazine, piperidine and morpholine." Acta Crystallographica Section B Structural Science 60, no. 2 (2004): 219–27. http://dx.doi.org/10.1107/s0108768104003672.

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The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so that the molecules interleave. In morpholine there are in addition weak CH...O interactions. Topological analyses show that these three structures are closely related to that of cyclohexane-II, which can be described in terms of a pseudo-cubic close-packed array of molecules in a familiar ABC layered arrangement. While the positions of

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10

CHAITANYA, G. DAVE, R. SHAH P., S. PANDYA P., and K. SHAH G. "Pyridopyrimidines. Part-VII. Synthesis and Antibacterial Activity of 4-lminopyrido[2, 3 - d] pyrimidin- 2( 1 H)-thiones, 2-Thioxopyrido[2, 3 - d]pyrimidin-4(3H)-ones and related Compounds." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 810–12. https://doi.org/10.5281/zenodo.6106035.

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Department of Chemistry, St. Xavier's College, Navarangpura, Ahmedabad-380 009 <em>Manuscript received 27 December 1988, revised 23 June 1989, accepted 26 June 1989</em> 2-Amino-3-cyano-4-(4-chlorophenyl)-6-phenylpyridine (I) and 2-amino·3·carboxamido-4-(4-chlorophenyl)·6-phenylpyridine (3) when reacted with various isothiocyanates, 4-amino-3·substituted-5-(4·chlorophenyl)-7·phenylpyrido[2,3-<em>d</em>]pyrimidin-2(1<em>H</em>)-thiones(2) and 2·thioxo-3-substituted-5-(4-chlorophenyl)-7-phenylpyrido[2,3-<em>d</em>]pyrimidin-4(3<em>H</em>)-ones

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11

Mazure, N., and N. Truffaut. "Degradation of morpholine by Mycobacterium aurum MO1." Canadian Journal of Microbiology 40, no. 9 (1994): 761–65. http://dx.doi.org/10.1139/m94-120.

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When Mycobacterium aurum MO1 was grown with morpholine, the release of ammonia into the supernatant was proportional to the disappearance of morpholine, showing that this compound was mineralized. MO1 was able to grow in high concentrations of morpholine but accumulation of ammonia inhibited growth and degradation of morpholine. Immobilization of bacterial cells in carrageenan gel beads showed that morpholine degradation in these conditions began earlier and was faster than in free culture. One of the two branches of the lower pathway of morpholine biodegradation was induced while the other br

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12

Poupin, P., N. Truffaut, B. Combourieu, et al. "Degradation of Morpholine by an EnvironmentalMycobacterium Strain Involves a Cytochrome P-450." Applied and Environmental Microbiology 64, no. 1 (1998): 159–65. http://dx.doi.org/10.1128/aem.64.1.159-165.1998.

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A Mycobacterium strain (RP1) was isolated from a contaminated activated sludge collected in a wastewater treatment unit of a chemical plant. It was capable of utilizing morpholine and other heterocyclic compounds, such as pyrrolidine and piperidine, as the sole source of carbon, nitrogen, and energy. The use of in situ1H nuclear magnetic resonance (1H NMR) spectroscopy allowed the determination of two intermediates in the biodegradative pathway, 2-(2-aminoethoxy)acetate and glycolate. The inhibitory effects of metyrapone on the degradative abilities of strain RP1 indicated the involvement of a

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13

Afsah, Elsayed M., Saad S. Elmorsy, Soha M. Abdelmageed, and Zaki E. Zaki. "Synthesis of some new hydrazide-hydrazones related to isatin and its Mannich and Schiff bases." Zeitschrift für Naturforschung B 71, no. 11 (2016): 1147–57. http://dx.doi.org/10.1515/znb-2016-0130.

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AbstractThe hydrazide-hydrazones 6a–d and 7a, b were obtained by treating isatin (1) or its Mannich base 2 with hydrazides incorporating piperidine, morpholine, and piperazine units. The reaction of 1 and 2 with hydrazides related to triazenes having piperidine, morpholine, and 1,2,3,4-tetrahydroisoquinoline moieties gave 12a–c and 13a–c. Treatment of 1 and 2 with iminodiacetohydrazide (14) and ethylenediamine tetraacetohydrazide (18) afforded 15–17 and 19a, b, respectively. The Mannich reaction of the Schiff base 20 with formaldehyde and the appropriate hydrazide or bis(hydrazide) gave 21a, b

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14

MØRKVED, EVA H., HELGE KJØSEN, HEGE OSSLETTEN, and NIKOLAI ERCHAK. "Syntheses of Octa(dialkylamino)azaphthalocyanines." Journal of Porphyrins and Phthalocyanines 03, no. 06 (1999): 417–23. http://dx.doi.org/10.1002/(sici)1099-1409(199908/10)3:6/7<417::aid-jpp150>3.0.co;2-f.

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Nickel(II) octa(4-morpholinyl)- (11a) and copper(II) octa(1-pyrrolidinyl)- (11b) azaphthalocyanines have been prepared from the corresponding pyrazine diiminoimides (10). The precursor pyrazine dicarbonitriles (2) gave 6-cyanopyrazine-5-alkyl carboximidates (3-9) as stable intermediates when reacted with ammonia and catalytic amounts of sodium alkoxide in alcohols. Compounds 3-9 were converted to the diiminoimides 10 upon reflux in propanol or butanol for several hours. This unusual reaction pattern was observed for pyrazine-2,3-dicarbonitriles 2 substituted in the 5- and 6-positions with morp

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15

G., BHATTACHARJEE, K. SINGH A., and SAIKIA R. "Kinetics of the Reaction of 2,3-[3-Norcaren-endo-2,5-diyl]-N-(2',4'-dinitrophenoxy)succinimide with Hydroxide lon, Piperidine, Morpholine and Cyclohexylamine. Base Catalysis with Hydroxide lon and Piperidine." Journal of Indian Chemical Society Vol. 68, Jul 1991 (1991): 407–8. https://doi.org/10.5281/zenodo.6158026.

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Department of Chemistry, University of Roorkee, Roorkee-247 667 <em>Manuscript received 19 February 1990, revised 17 June 1991, accepted 26 June 1991</em> Kinetics of the Reaction of 2,3-[3-Norcaren-<em>endo</em>-2,5-diyl]-<em>N</em>-(2',4'-dinitrophenoxy)succinimide with Hydroxide lon, Piperidine, Morpholine and Cyclohexylamine. Base Catalysis with Hydroxide lon and Piperidine.

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16

K., S. Nimavat, H. Popat K., L. Vasoya S., and S. Joshi H. "Synthesis and antimicrobial activity of some new aminobenzylated Mannich bases." Journal of Indian Chemical Society Vol. 80, July 2003 (2003): 711–13. https://doi.org/10.5281/zenodo.5835566.

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Department of Chemistry, Saurashtra University, Rajkot-360 005, India <em>E-mail</em> : drhsjoshi@yahoo.com                  <em> Fax:</em> 91-281-578512 <em>Manuscript received 4 April 2002, revised 1 January 2003, accepted 21 March 2003</em> 3-Bromobenzaldehyde has been condensed with piperidine, morpholine, indole, <em>N</em>-methylpiperazine to give intermediate Ncyclic phenylcarbinols which on condensation with acetamide, urea and thiourea, having active hydrogen functions, give the new aminobenzylated Mannich bases (1a-d, 2a-d, 3a-d). The

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17

McAdam, C. John, Joy L. Morgan, R. Eva Murray, Brian H. Robinson, and Jim Simpson. "Synthesis and Fluorescence Properties of New Enaminenaphthalimides." Australian Journal of Chemistry 57, no. 6 (2004): 525. http://dx.doi.org/10.1071/ch03285.

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The first 4-enamine-N-methyl-1,8-naphthalimides (amine = piperidine, pyrrolidine, morpholine, Prn2NH, Pri2NH) are reported. The X-ray crystal structure of the piperidine derivative confirmed the E-stereochemistry and showed strong Π–Π stacking in the unit cell. The enamines are strongly fluorescent and quantum yields do not vary with the pKb of the amine. The solvent dependence of λ abs and λ flu is consistent with significant charge separation in the excited state.

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18

Petrov, O. A., A. A. Maksimova, A. E. Rassolova, G. A. Gamov, and E. E. Maizlish. "Reactivity of Tetraphenoxy-Substituted Phthalocyanines in Acid–Base Reactions with Organic Bases." Журнал физической химии 97, no. 9 (2023): 1290–96. http://dx.doi.org/10.31857/s0044453723090157.

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The interaction of tetra-4-(2-methoxyphenoxy)phthalocyanine and tetra-4-(3-methoxyphenoxy)phthalocyanine with pyridine, 2-methylpyridine, morpholine, piperidine, n-butylamine, tert-butylamine, diethylamine, and triethylamine in benzene has been studied. The acid–base reaction involving n-butylamine and piperidine is an unusually slow process, leading to the formation of kinetically stable proton transfer complexes. The structure of these complexes is proposed. The change in the reactivity of tetraphenoxy-substituted phthalocyanines depending on the proton-acceptor ability and spatial structure

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19

Oswald, Iain D. H., W. D. Samuel Motherwell, and Simon Parsons. "Formation of quinol co-crystals with hydrogen-bond acceptors." Acta Crystallographica Section B Structural Science 61, no. 1 (2005): 46–57. http://dx.doi.org/10.1107/s0108768104028605.

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The crystal structures of eight new co-crystals of quinol with pyrazine, piperazine, morpholine, pyridine, piperidine, 4,4′-bipyridine, N-methylmorpholine and N,N′-dimethylpiperazine are reported. Quinol forms 1:1 co-crystals with pyrazine, piperazine and N,N′-dimethylpiperazine, but 1:2 co-crystals with morpholine, 4,4′-bipyridine, N-methylmorpholine, pyridine and piperidine. This difference can be rationalized in most cases by the presence of, respectively, two or one strong hydrogen-bond acceptor(s) in the guest molecule. The exception to this generalization is 4,4′-bipyridine, which forms

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20

Wieczorek, Daria, Dobrawa Kwaśniewska, Li-Hang Hsu, Tang-Long Shen, and Ying-Lien Chen. "Antifungal Activity of Morpholine and Piperidine Based Surfactants." Tenside Surfactants Detergents 57, no. 2 (2020): 104–8. http://dx.doi.org/10.3139/113.110667.

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21

Zolotareva, Darya, Alexey Zazybin, Anuar Dauletbakov, et al. "Morpholine, Piperazine, and Piperidine Derivatives as Antidiabetic Agents." Molecules 29, no. 13 (2024): 3043. http://dx.doi.org/10.3390/molecules29133043.

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Diabetes mellitus is a severe endocrine disease that affects more and more people every year. Modern medical chemistry sets itself the task of finding effective and safe drugs against diabetes. This review provides an overview of potential antidiabetic drugs based on three heterocyclic compounds, namely morpholine, piperazine, and piperidine. Studies have shown that compounds containing their moieties can be quite effective in vitro and in vivo for the treatment of diabetes and its consequences.

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22

R., S. VARMA, and GUPTA PREETI. "Nucleophilic Addition-Elimination Reactions of 4- and 6-Chloroindolin-2, 3-diones with 6-Chloro-2- hydrazinobenzothiazole." Journal of Indian Chemical Society Vol. 66, May 1989 (1989): 325–26. https://doi.org/10.5281/zenodo.5995356.

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Department of Chemistry, Lucknow University. Lucknow-:126 007 <em>Manuscript received 12 December 1988, accepted 21 February 1989</em> 4-Chloroindolin•2,3-dione (Ia) and its 1-methyl analog (2a) undergo nucleophilic addition-elimination reaction with 6-chloro 2-hydrazinobenzothiazole to yield 4-chloro•3- (6' -chloro-2' -hydrazonobenzothiazolyl)-2-indolinone (3a) and 4-chloro-1-methyl·3-(6' -chloro-2-hydrazonobenzothiazolyl)-2-indolinone (4a) respectively. Similarly, 6-chloroindolin-2,3-dione (1b) and its 1-methyl analog (2b) yielded 3b and 4b respectively. 3a

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23

R., S. VARMA, and PREETI GUPTA (Miss). "Nucleophilic Reactions of 2-Methyl-3-( 4' -carbomethoxyphenyl)-4-quinazolinones with 2-lndolinones." Journal of Indian Chemical Society Vol. 66, Nov 1989 (1989): 804–5. https://doi.org/10.5281/zenodo.6090915.

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Department of Chemistry, Lucknow University, Lucknow-226 007 <em>Manuscript received 10 March 1989, accepted 20 June 1989</em> 2-Methyl-3-(4'-carbomethoxphenyl)-4-quinazolinone undergoes nucleophilic addition-elimination reactions with different lndolinones leading to 2-(3-methylene- substituted-oxindolyl)-3-(4'-carbomethoxyphenyl)-4-quinazolinones (2a- e), Similarly, <em>N</em>-methylindolinones react with 2-methyl-3-(4'-carbomethoxyphenyl)-4-quinazolinone to give 2- (3-methylene-1- methyl-substituted -oxindolyl)- 3 -( 4' - carbomethoxyphenyl)-4 quinazolinones (4a -e). Mannich

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24

Ballerat-Busserolles, Karine, Mickaël R. Simond, Yohann Coulier, and Jean-Yves Coxam. "Protonation of alkanolamines and cyclic amines in water at temperatures from 293.15 to 373.15 K." Pure and Applied Chemistry 86, no. 2 (2014): 233–43. http://dx.doi.org/10.1515/pac-2014-5017.

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Abstract The protonation properties of amines are of particular interest for the development of thermodynamic models representative of CO2 dissolution in aqueous solutions. This paper reports experimental equilibrium constants of protonation of alkanolamines (2-aminoethanol, 2,2′-iminodiethanol, 2-[bis(2-hydroxyethyl)amino]ethanol, 2-amino-2-methylpropan-1-ol, 2,2′-(methylimino)diethanol and cyclic amines (morpholine, 4-methylmorpholine, pyridine, 1-methyl-piperidine, 2-methyl-piperidine, 2,6-dimethylpiperidine). The equilibrium constants of protonation were determined by potentiometric techni

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25

Piekarski, Mikołaj, Agnieszka Dołhań, Judyta Cielecka-Piontek, et al. "The Influence of pH and Temperature on the Stability ofN-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and Its Four New Amidine Derivatives in Aqueous Solutions." Scientific World Journal 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/803789.

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The influence of pH and temperature on the stability ofN-[(piperidine)methylene]daunorubicin hydrochloride (PPD) was investigated. Degradation was studied using an HPLC method. Specific acid-base catalysis of PPD involves hydrolysis of protonated molecules of PPD catalyzed by hydrogen ions and spontaneous hydrolysis under the influence of water zwitterions, unprotonated molecules, and monoanions of PPD. The thermodynamic parameters of these reactions, energy, enthalpy, and entropy, were calculated. Also, the stability of daunorubicin and its new amidine derivatives (piperidine, morpholine, pyr

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26

Špirková, Katarína, Rudolf Kada, Jaroslav Kováč, Viera Knoppová, Miroslav Dzuroška, and Margita Margušová. "A study of reactions of 5-substituted furfurylidene derivatives with secondary amines." Collection of Czechoslovak Chemical Communications 50, no. 2 (1985): 459–69. http://dx.doi.org/10.1135/cccc19850459.

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The paper describes preparation of 5-bromo-, 5-nitro-, 5-phenylsulphonyl-, and 5-phenylthio-2-furfurylidene derivatives and investigation of their reactions with N-phenylpiperazine, morpholine, piperidine, and pyrrolidine. Kinetics of the reactions have been followed, and UV, IR, and 1H NMR spectra of the compounds produced are interpreted.

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27

G., BHATIACHARJEE, K. SINGH A., and GUPTA ANSHU. "Aminolysis of 2,3-Cyclopenten-3',5' -diyl]-endo-N-(2",4"-dinitrophenoxy)-succinimide with Morpholine, Piperidine, Pyrrolidine and Cyclohexylamine in Ethyl Acetate." Journal of Indian Chemical Society Vol. 75, Jan 1998 (1998): 49–51. https://doi.org/10.5281/zenodo.5913206.

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Department of Chemistry. University of Roorkee, Roorkee-247 667 <em>Manuscript received 22 July 1996, revised 3 December 1996, accepted 8 April 1997</em> Aminolysis of 2,3-Cyclopenten-3',5' -diyl]-endo-<em>N</em>-(2",4"-dinitrophenoxy)-succinimide with Morpholine, Piperidine, Pyrrolidine and Cyclohexylamine in Ethyl Acetate.

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28

Sovilj, Sofija, Dragana Mitic, Branko Drakulic, and Marina Milenkovic. "Spectroscopic properties and antimicrobial activity of dioxomolybdenum(VI) complexes with heterocyclic S,S’-ligands." Journal of the Serbian Chemical Society 77, no. 1 (2012): 53–66. http://dx.doi.org/10.2298/jsc110328160s.

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Five new dioxomolybdenum(VI) complexes of the general formula[MoO2(Rdtc)2], 1-5, where Rdtc-refer to piperidine- (Pipdtc), 4-morpholine-(Morphdtc), 4-thiomorpholine-(Timdtc), piperazine- (Pzdtc) or Nmethylpiperazine- (N-Mepzdtc) dithiocarbamates, respectively, have been prepared. Elemental analysis, conductometric measurements, electronic, IR and NMR spectroscopy have been employed to characterize them. Complexes 1-5 contain a cis-MoO2 group and are of an octahedral geometry. Two dithiocarbamato ions join as bidentates with both the sulphur atoms to the molybdenum atom. The presence of differe

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29

Nguyen, Thi Thu Huong, Jiří Protiva, Eva Klinotová, Jiří Urban та Miroslav Protiva. "Synthesis of 24-(Piperidin-1-yl, Morpholin-4-yl and 4-Methylpiperazin-1-yl)-5β-cholan-3α-ols and Four Hydroxylated 23-(4,5-Dihydroimidazol-2-yl)-24-nor-5β-cholanes". Collection of Czechoslovak Chemical Communications 62, № 3 (1997): 471–78. http://dx.doi.org/10.1135/cccc19970471.

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Lithocholic (1a), chenodeoxycholic (1b), deoxycholic (1c) and cholic acid (1d) were used for the synthesis of the title compouds. Reactions of O-acetyllithocholic acid chloride with piperidine, morpholine and 1-methylpiperazine gave the corresponding amides 2a-2c which were reduced with lithium aluminium hydride to 24-(piperidin-1-yl)-5β-cholan-3α-ol (3a) and analogues 3b and 3c. Heating of the acids 1a-1d with ethylenediamine monotosylate afforded 23-(4,5-dihydroimidazol-2-yl)-24-nor-5β-cholan-3α-ol (4a) and analogues 4b-4d. Compound 4a was similarly obtained from 3α-acetoxy-24-nor-5β-cholane

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30

Lebedeva, Natalia Sh, Natalia A. Pavlycheva, Elena V. Parfenyuk, Anatoly I. Vyugin, and Elena A. Malkova. "Crystallosolvates of Zn(II)-tetra-tert-butylphthalocyanine with organic ligands: spectroscopic and thermogravimetric studies." Journal of Porphyrins and Phthalocyanines 07, no. 08 (2003): 558–64. http://dx.doi.org/10.1142/s1088424603000707.

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Molecular complexes of Zn (II)-tetra-tert-butylphthalocyanine ( Zn ( tert - Bu )4 Pc ) with organic ligands (piperidine, morpholine, 1,4-dioxane) were obtained. The stoichiometry, energetic stability and decomposition temperature of the complexes were determined. The effect of specific solvation interactions with the organic solvents on the polymorphic state of Zn ( tert - Bu )4 Pc was determined.

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31

Hammouda, M., W. S. Hamama, and E. M. Afsah. "A Study on the Mannich Reaction with 1-Phenylamino-3-indenone." Zeitschrift für Naturforschung B 42, no. 1 (1987): 94–96. http://dx.doi.org/10.1515/znb-1987-0118.

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Abstract Mannich reaction of the title compound 1 with formaldehyde and morpholine, piperidine or piperazine afforded the Mannich bases 3-5 respectively, whereas the indeno[1.2-d]pyrimidines (6-7) were obtained where primary amines were used. Treatment of 2 with formaldehyde gave benz[b]indeno-diazepine (8). The reaction of formaldehyde with 1 was also investigated.

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32

Xu, S., F. D. Otto, and A. E. Mather. "Dissociation constants of some alkanolamines." Canadian Journal of Chemistry 71, no. 7 (1993): 1048–50. http://dx.doi.org/10.1139/v93-139.

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The dissociation constants of piperidine (PD), 1-piperidineethanol (1–PE), N-methylmorpholine (MML), 4-(2-hydroxyethyl)morpholine (4-EML), and tropine (TP) have been determined at 15.0, 25.0, 35.0, 45.0, and 60.0 °C. The standard state enthalpy changes of the dissociation reaction for these amines have been obtained from the dependence of the dissociation constants upon temperature.

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33

Flores-Parra, Angelina, Gregorio Cadenas-Pliego, Rosalinda Contreras, Noe Zuniga-Villarreal, and Maria de los Angeles Paz-Sandoval. "Symmetry loss in piperidine and morpholine by nitrogen coordination." Journal of Chemical Education 70, no. 7 (1993): 556. http://dx.doi.org/10.1021/ed070p556.

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34

Meinert, H., R. Fackler, J. Mader, and P. Reuter. "On the electrofluorination of derivatives of morpholine and piperidine." Journal of Fluorine Chemistry 45, no. 1 (1989): 93. http://dx.doi.org/10.1016/s0022-1139(00)84465-6.

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35

Todres, Z. V., and D. S. Ermekov. "?-Iodo-?-nitrostilbene in the reaction with morpholine and piperidine." Bulletin of the Russian Academy of Sciences Division of Chemical Science 41, no. 5 (1992): 957–59. http://dx.doi.org/10.1007/bf00864548.

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36

Altıntop, Mehlika Dilek. "Synthesis, In vitro and In silico Evaluation of a Series of Pyrazolines as New Anticholinesterase Agents." Letters in Drug Design & Discovery 17, no. 5 (2020): 574–84. http://dx.doi.org/10.2174/1570180816666190618111023.

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Background: Pyrazolines, electron-rich nitrogen carriers, are of great importance due to their potential applications for the treatment of many diseases including inflammation, infectious diseases and neurodegenerative disorders. Objectives: The purpose of this work was to synthesize new pyrazoline derivatives and evaluate their anticholinesterase effects. Methods: 1-Aryl-5-[4-(piperidin-1-yl)phenyl]-3-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazoles (1-7) were synthesized via the treatment of 1-(3,4-dimethoxyphenyl)-3-[4-(piperidin-1-yl)phenyl]prop-2- en-1-one with arylhydrazine hydrochloride d

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37

Vít, Zdeněk. "A new route to copper(II) μ4–oxo complexes Cu4OHal6I4". Collection of Czechoslovak Chemical Communications 52, № 5 (1987): 1231–34. http://dx.doi.org/10.1135/cccc19871231.

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A novel procedure is suggested for the preparation of tetranuclear copper(II) μ4–oxo complexes Cu4OHal6L4 with N-heterocycles as ligands, consisting of the oxidation of piperidine or morpholine complexes of copper(I) halides with organic polyhalo compounds in the presence of water. The reaction proceeds readily even at room temperature giving the product in a high yield (up to 88%).

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38

Shahbazi-Alavi, Hossein, Seyed Hadi Nazemzadeh, Abolfazl Ziarati, and Javad Safaei-Ghomi. "Nano-NiZr4(PO4)6 as a superior catalyst for the synthesis of propargylamines under ultrasound irradiation." Zeitschrift für Naturforschung B 73, no. 3-4 (2018): 185–89. http://dx.doi.org/10.1515/znb-2017-0178.

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AbstractAn easy and rapid method for the synthesis of propargylamines has been achieved through a three-component reaction of phenylacetylene, aromatic aldehydes, and morpholine or piperidine using nano-NiZr4(PO4)6under ultrasound irradiation. Atom economy, a wide range of products, excellent yields in short times, reusability of the catalyst, and low catalyst loading are some of the important features of this protocol.

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39

Agamaliyeva, M. M., A. M. Pashajanov, T. M. Ismailov, N. I. Ismailov, and G. O. Hasanova. "AMINOMETHYLATION OF DIHYDROXYACETOPHENONES." Azerbaijan Chemical Journal, no. 3 (September 22, 2022): 81–86. http://dx.doi.org/10.32737/0005-2531-2022-3-81-86.

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Aminomethylation of trifunctional 2.5-dihydroxyacetophenone (2.5-DHA) and 2.4-dihydro¬xy¬aceto-phenone (2.4-DHA) by free primary and secondary amines in the presence of formaldehyde has been conducted for the first time. It has been established that 2.5-DHA is aminomethylated with secondary heterocyclic amines - piperidine and morpholine and with aqueous formaldehyde solution in alcohol medium at 500C. The reaction proceeds simultaneously via all three functions forming stable C,O-substitution products − β-amino-2-aminomethoxy-4-aminomethyl-5-hydroxypropiophenones. The aminomethylation reactio

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40

Sharma, Mousami, Anju Sharma, and Renu Sachar. "Synthesis and Characterization of the Adducts of Morpholinedithioccarbamate Complexes of Oxovanadium (IV), Nickel(II), and Copper(II) with Piperidine and Morpholine." E-Journal of Chemistry 9, no. 4 (2012): 1929–40. http://dx.doi.org/10.1155/2012/689501.

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A series of 1:1 adducts of bis(morpholinedithiocarbamato) complex of VO(IV), 1:1 and 1:2 adducts of bis(morpholinedithiocarbamato) complexes of Ni(II) and Cu(II) with piperidine and morpholine have been synthesized and characterized by elemental analysis, molar conductance, magnetic susceptibility, IR, UV-Vis, and TGA/DTA techniques. Analytical data reveals that VO(IV) complex forms only 1:1 adducts with the formula [VO(morphdtc)2L].H2O while Ni(II) and Cu(II) complexes form both 1:1 and 1:2 adducts with 1:1 adducts having general formula Ni(morphdtc)2.L and Cu(morphdtc)2.L and 1:2 adducts hav

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41

Dostál, Jiří, Milan Potáček, and Miloslav Nechvátal. "Reactions of 5-Methylphenanthridinium Iodide with Nucleophiles and Reaction Products Conversion." Collection of Czechoslovak Chemical Communications 58, no. 2 (1993): 395–403. http://dx.doi.org/10.1135/cccc19930395.

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Reactions of 5-methylphenanthridinium iodide (I) with oxygen, nitrogen, and carbon nucleophiles, respectively, were studied. 5-Methylphenanthridinium iodide (I) yielded in the basic aqueous medium 5-methyl-6-phenanthridone (II) and 5,6-dihydro-5-methylphenanthridine (III). By NMR spectroscopy in the D2O-CD3CN solution 5,6-dihydro-6-deuteroxy-5-methylphenanthridine (IVb) (pseudobase) was observed as an immediate unstable product. 5-Methylphenanthridinium iodide (I) gave the corresponding adducts with methoxide and ethoxide anions, morpholine, piperidine, pyrrolidine, cyanide anion and acetone.

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42

Štetinová, Jarmila, Adolf Jurášek, Jaroslav Kováč, Miloslava Dandárová, and Oľga Rajniaková. "Synthesis and properties of 4-alkylaminomethyl and 4-alkoxymethyl derivatives of 5-methyl-2-furancarboxylic acid." Collection of Czechoslovak Chemical Communications 51, no. 10 (1986): 2186–92. http://dx.doi.org/10.1135/cccc19862186.

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New β-substituted amines and ethers of the furan series (II-V) were prepared by reaction of methyl 4-bromomethyl-5-methyl-2-furancarboxylate (I) with nucleophiles such as pyrrolidine, piperidine, morpholine, N-phenylpiperazine, cyclohexylamine, 2-methylcyclohexylamine, N-ethylaniline, p-toluidine, ethanol, butanol and salicylaldehyde. The structure of the products was confirmed by their analytical and spectral data. Kovats indices I for the products were determined using gas-liquid chromatography.

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43

Baikenova, G. G., G. A. Abdulina, A. M. Gazaliev, S. D. Fazylov, and S. Zh Kudaibergenova. "Synthesis and Antimicrobial Activity of Anabasine, Piperidine, and Morpholine Dithiocarbamates." Pharmaceutical Chemistry Journal 38, no. 1 (2004): 19–20. http://dx.doi.org/10.1023/b:phac.0000027638.24327.bd.

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44

Meinert, H., R. Fackler, J. Mader, P. Reuter, and W. Rohlke. "On the electrochemical fluorination of derivatives of morpholine and piperidine." Journal of Fluorine Chemistry 51, no. 1 (1991): 53–73. http://dx.doi.org/10.1016/s0022-1139(00)80306-1.

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45

Meinert, H., R. Fackler, J. Mader, P. Reuter, and W. Röhlke. "The electrochemical fluorination of derivatives of morpholine, piperidine and carbazole." Journal of Fluorine Chemistry 59, no. 3 (1992): 351–65. http://dx.doi.org/10.1016/s0022-1139(00)80330-9.

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46

Stockhausen, M., and G. Wilke. "Dielectric Relaxation of N-Cyano Substituted Morpholine, Piperidine and Pyrrolidine." Berichte der Bunsengesellschaft für physikalische Chemie 95, no. 8 (1991): 929–33. http://dx.doi.org/10.1002/bbpc.19910950813.

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47

Chunduru, Srinivasa Rao, Venkata Ramana Reddyy Ch., Jyotsna C., and S. Sait Shakil. "Synthesis of 3-[5-(morpholinomethyl/piperidinomethyl/pyrrolidinemethyl)-1 ,2 ,4- oxadiazol-3-yl]-4H-chromones." Journal of Indian Chemical Society Vol. 90, Sep 2013 (2013): 1461–66. https://doi.org/10.5281/zenodo.5790902.

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Department of Chemistry, JNTU, Kukatpally, Hyderabad-500 085, India Dr. Reddy Laboratories, Bachupally, Hyderabad-500 090, India <em>E-mail </em>: chemistrycsr@gmail.com <em>Manuscript received online 04 November 2012, revised 05 December 2012, accepted 30 December 2012</em> 5-(Chloromethyl)-3-(4<em>H</em>-chromen-3-yl)-1,2,4-oxadiazole (1a-e) react with pyrrolidine (6) to give 3-(4<em>H</em>-chromen-3-yl)-5-(pyrrolidin-1-ylmethyl)-1,2,4-oxadiazole (7a-e), (1a-e) react with piperidine (4) to give 1-{[3-(4<em>H</em>-chromen-3-yl)- 1,2,4-oxadiazol-5-yl]methyl}piperidine (5a-e) and (1a-e) react w

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48

Ivakhnenko, E. P., V. I. Malay, O. P. Demidov, and V. I. Minkin. "Reaction of 4,6-di-<i>tert</i>-butyl-3-nitrocyclohex-3,5-diene1,2-dione with secondary amines." Журнал органической химии 59, no. 8 (2023): 1032–40. http://dx.doi.org/10.31857/s0514749223080049.

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Reaction of 4,6-di- tert -butyl-3-nitrocyclohexa-3,5-diene-1,2-dione with secondary amines (piperidine, morpholine, 1-methylpiperazine) in isopropanol leads to a mixture of products formed as a result of parallel reactions of Michael addition and ANRORC. The compounds obtained were characterized by 1H NMR, 13C NMR, IR spectroscopy, and elemental analysis. Molecular structure of 3-nitrocyclohexa-3-ene-1,2-dione and cyclopenta1,3-diene derivatives was established by X-ray diffraction analysis.

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49

Šilhánková, Alexandra, Karel Šindelář, Karel Dobrovský, Ivan Krejčí, Jarmila Hodková, and Zdeněk Polívka. "Synthesis of New L-Proline Amides with Anticonvulsive Effect." Collection of Czechoslovak Chemical Communications 61, no. 7 (1996): 1085–92. http://dx.doi.org/10.1135/cccc19961085.

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Series of heterocyclic L-proline amides were prepared from BOC-L-proline and heterocyclic amines (mostly substituted piperazines and morpholines) via active ester with hydroxysuccinimide. 4-(4-Fluorobenzoyl)piperidine afforded L-proline 4-(4-(4-(4-fluorobenzoyl)piperidin-1-yl)benzoyl)piperidine (7b) simultaneously with expected L-proline 4-(4-fluorobenzoyl)piperidide (7a). D-Proline N-(3-(4-(3-chlorophenyl)piperazin-1-yl)propyl)amide (2) was prepared starting from D-proline. The amides were tested by methods of biochemical and behavioural pharmacology.

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50

Hamama, W. S., M. Hammouda, and E. M. Afsah. "Mannich Reaction with 5,5-Dimethyl-3-phenylamino-2-cyclohexen-1-one." Zeitschrift für Naturforschung B 43, no. 4 (1988): 483–86. http://dx.doi.org/10.1515/znb-1988-0417.

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AbstractMannich reaction of the title compound 1 with morpholine, piperidine or piperazine gave the keto-bases 2-4, respectively. Whereas, such reaction with primary amines afforded the quinazolinones 5 and 6. Compound 1 reacts with isonicotinic acid hydrazide and formalin to give 7. Schmidt reaction of 4 and 5a gave 8 and 9, respectively. Reduction of the latter afforded the 9H-pyrimido[5,4-ḇ]azepine ring system 10. The reaction of 1 with formalin was investigated.

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