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Dissertations / Theses on the topic 'Piperidine synthesis'

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Published: 4 June 2021

Last updated: 2 February 2022

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1

Lewis, Neil. "Asymmetric piperidine synthesis." Thesis, University of Nottingham, 1995. http://eprints.nottingham.ac.uk/13293/.

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It has been demonstrated that bakers' yeast reduction of 1-tert-butyl-2-methyl 3-oxo-piperidine-1,2-dicarboxylate gives (2R, 3S), 1-tert-butyl-2-methyl 3-hydroxy-piperidine-1,2-dicarboxylate in 80% chemical yield with >99% d.e. and >97% e.e. Also bakers' yeast reduction of 1-tert-butyl-3-ethyl 4-oxo-piperidine-1,3-dicarboxylate gives (3R, 4S), 1-tert-butyl-3-ethyl4-hydroxy-piperidine-1,3-dicarboxylate in 74% chemical yield with >99% d.e. and >93% e.e. The optical purity and absolute configurations of the hydroxy-ester derivatives were determined by conversion into the corresponding chiral bis-

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2

Taylor, Sarah Alison. "Sulfur-mediated pyrrolidine and piperidine synthesis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613286.

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3

Mosts, R. C. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379495.

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4

Lenagh-Snow, Gabriel Matthew Jack. "The synthesis of azetidine and piperidine iminosugars from monosaccharides." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:207235d5-2ea5-4724-92fd-924fa0ccd4ed.

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Iminosugars are polyhydroxylated alkaloids, and can be generally defined as sugar mimetics in which the endocyclic oxygen atom has been replaced with a basic nitrogen. A common affect of this atomic substitution is to bestow these compounds with the ability to inhibit various sugarprocessing enzymes; most significantly the glycosidases (glycoside hydrolases) which areintimately involved in a huge array of biological functions. Compounds which inhibit these enzymes concordantly possess much potential as medicinal agents for the treatment of a variety of diseases. Several iminosugars have alread

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5

Adams, David Roger. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236570.

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6

Eskici, Mustafa. "Asymmetric piperidine synthesis via 1,3-cyclic sulfates." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368215.

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7

Adriaenssens, Louis. "Stereoselective synthesis of piperidines." Thesis, Connect to e-thesis to view edited abstract. Move to record for print version, 2008. http://theses.gla.ac.uk/49/.

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8

Abdelsalam, Mansour. "Synthesis of piperidines using organometallic chemistry." Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4069/.

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9

Williams, Jodi Thomas. "Stereoselective piperidine synthesis via ene and carbonyl ene cyclisations." Thesis, Oxford Brookes University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289247.

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10

Smith, Peter Duncan. "Synthesis of pipecolic acid derivatives via aza-Diels-Alder reactions." Thesis, Heriot-Watt University, 2000. http://hdl.handle.net/10399/552.

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11

Woods, Gordon Alexander. "Synthetic approaches to functionalised piperidines." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4c6fdb6c-c021-447c-8fc9-35241b552850.

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This thesis is concerned with the synthesis of functionalised piperidines. The piperidine unit is found in numerous alkaloids and other natural products, and has also been incorporated into synthetic compounds of significant therapeutic or strategic synthetic potential. Although numerous syntheses of individual piperidine compounds have been published, there are few general routes to this class of compounds, and there is therefore a need for such routes to be developed. Bicyclic lactams derived from (S)-pyroglutamic acid have been shown to be useful synthons in the synthesis of pyrrolidines. A

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12

Archibald, Glenn Philip. "Use of novel nitrones in the synthesis of piperidine alkaloids." Thesis, University of Auckland, 2011. http://hdl.handle.net/2292/7127.

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The current study focused on development of a flexible synthetic strategy for the enantioselective preparation of 2-substituted-3-hydroxypiperidines utilising chiral 3-hydroxytetrahydropyridine N-oxides. Initial studies into the regio- and stereoselectivity of the 1,3-dipolar cycloaddition reaction between O-benzyl protected 3-hydroxytetrahydropyridine N-oxide 208 and a range of alkenes, proceeded with excellent exo/endo selectivity and near perfect regioselectivity. However the anti/syn selectivity was only moderately in favour of the desired anti-compounds. Further development has led to the

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13

Coggins, P. "Syntheses with 2-alkyl-2,3,4,5-tetrahydropyridine-1-oxides." Thesis, University of Exeter, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235969.

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14

Moore, Rebecca J. "Novel approaches to natural product synthesis using organozinc intermediates." Thesis, University of Newcastle Upon Tyne, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362516.

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15

Harkiss, Alexander Hugh. "Synthesis of novel fluorescent heterocyclic-derived α-amino acids and the total syntheses of piperidine natural products". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8629/.

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During the course of this PhD, methodology for the synthesis of a series of novel, highly fluorescent pyridine-derived α-amino acids was developed. Enone-derived α-amino acids were subjected to an inverse electron demand hetero-Diels-Alder cycloaddition and aromatisation reaction, which led to a twelve-membered library of pyridine analogues. The optical properties of these compounds were analysed, with several exhibiting interesting fluorescent characteristics. One of the analogues was incorporated into a cell penetrating pentapeptide via solid phase peptide synthesis. The resulting hexapeptid

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16

Lansakara, Ashabha Indrashika. "Intramolecular cyclizations of alkyl pyridines & alkylidene dihydropyridines as synthetic intermediates toward synthesis of bis(piperidine) alkaloids." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/2105.

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Nature provides fascinating and complicated molecular structures which offer synthetic organic chemists amazing opportunities for the design of new strategies for natural product synthesis. Among these, nitrogen containing aza-heterocycles are of unparalleled importance in natural product, bioorganic, and medicinal chemistry. Pyridine and its derivatives in particular are the most common aza-heterocycles encountered in natural products, medicinal and materials chemistry. Pyridine derivatives also serve as precursors to fun

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17

Gu, Xiaobo. "Synthesis and SAR study of Meperidine Analogues as Selective Serotonin Reuptake Inhibitors (SSRIs)." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1111.

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Meperidine has been shown to have potent binding affinity for serotonin transporters (SERT) (Ki = 41 nM) and be an inhibitor of serotonin reuptake. Based upon these pharmacological results meperidine has been identified as a lead compound for the development of a novel class of serotonin-selective reuptake inhibitors (SSRIs). A variety of potent analogues of meperidine have been synthesized and evaluated in vitro as potential ligands for the serotonin transporter. Substitutions have been made on the aryl ring, the ester moiety and the piperidine nitrogen of meperidine. Potent analogues o

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18

Moraux, Thomas. "Synthesis and evaluation of α-fluoro analogues of capsaicin and 2-(aminomethyl)piperidine derivatives". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2094.

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Chapter 1 gives an overview of the fluorine chemistry field, from its early developments to recent applications in medicinal chemistry. The development of asymmetric electrophilic or nucleophilic installation of fluorine in organic molecules is highlighten. Chapter 2 of this thesis discusses the enantioselective synthesis of α-fluoroamides. The study is applied to the synthesis of fluoroenantiomers of the bioactive molecule capsaicin and short-chain analogues. The biological activity of these compounds is assayed with the TRPV1 receptor. Results show that enantioselective α-fluoroamides (R)-97

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19

Pöschl, Anna. "Synthesis of novel piperidine building blocks and their use for the preparation of donepezil analogues." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/synthesis-of-novel-piperidine-building-blocks-and-their-use-for-the-preparation-of-donepezil-analogues(7bca2c61-fc01-4496-adb5-b42872749a34).html.

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The piperidine moiety is found in a vast number of bioactive natural products as well as numerous marketed drugs and is therefore an interesting target for synthetic modi cations. Synthetic piperidines currently in the clinic are predominantly limited to 1,4-disubstitution on the piperidine ring, hence it is important to develop strategies to access new drug candidates with diverse substitution con gurations on the ring. For this purpose, the aza-Michael reaction can be used as an atom-ecient method to access biologically important piperidines. An initial study into the utility of divinyl keto

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20

Oh, Seongho. "Optimization and extensions of the nucleophile catalyzed aldol-lactonization (NCAL) process for bicyclic beta-lactone synthesis: applications to piperidine, pyrrolidine, and gamma-lactam-fused beta-lactones." Texas A&M University, 2003. http://hdl.handle.net/1969.1/3961.

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The intramolecular nucleophile catalyzed aldol-lactonization (NCAL) process was optimized successfully. A variety of C9-acylated cinchona alkaloids were synthesized and used for NCAL reactions with non-activated aldehydes. New pyridinium salts, derivatives of MukaiyamaÂs reagent, led to marked improvements in efficiency for the catalytic, asymmetric NCAL process while maintaining high enantioselectivity. Larger scale versions of the catalytic, asymmetric NCAL reaction were also developed allowing practical access to chiral bicyclic b-lactones. As an extension of the intramolecular NCAL proces

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21

Silvestrini, Filippo. "A DFT study on chemodivergent preparation of piperidinic and morpholinic heterocycles." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20660/.

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The topic of this thesis is the DFT computational study of the mechanisms for the synthesis of chiral 3,4,5-trisubstituted piperidines and 2,6-disubstituted morpholines. The goal of this synthesis is to use, the same substrate containing two electrophilic sites: an α,β-unsaturated ester and a ketone, which evolve according to the nucleophile used (cyanide, phenyl sulfide) through different addition and cyclization reactions. A quaternary ammonium salt is used as a catalyst for these reactions, which leads to a diastereoisomeric excess both for the reactions of morpholine and piperidine product

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22

Andersson, Hans. "Reaction between grignard reagents and heterocyclic N-oxides synthesis of substituted pyridines, piperidines and piperazines /." Doctoral thesis, Umeå : Department of Chemistry, Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25619.

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23

Vu, Van Ha. "Cyanation anodique et réaction de Fry modifiée : application à la synthèse stéréosélective d’alcaloïdes de la pipéridine." Thesis, Rennes 1, 2014. http://www.theses.fr/2014REN1S138/document.

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Les alcaloïdes de la pipéridine sont des composés présents à la fois dans le règne animal et végétal. L'approche générale que nous avons développée au cours de ce travail de thèse est basée sur l'utilisation de différents -aminonitriles qui ont été préparés soit par réduction de sels de pyridinium chiraux soit par cyanation anodique d'amines tertiaires dérivées de l'-phényl-éthylamine. Dans le premier cas, la modification de la réaction de Fry nous a permis de préparer les deux énantiomères de la coniine qui constitue l'agent toxique de la grande cigüe (Conium maculatum). En combinant cette mé

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24

Anhettigama, Gamaralalage Medha Jaimini Gunaratna. "Design, synthesis and bio-evaluation of piperidines and CGRP peptides; Synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38204.

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Doctor of Philosophy<br>Department of Chemistry<br>Duy H. Hua<br>Three research projects are described in this dissertation, and they are: (i) discovery of piperidine derivatives as T-type calcium channel inhibitors for the treatment of epilepsy and neuropathic pain and as protein disulfide isomerase inhibitors for the treatment of influenza viral infection; (ii) discovery of peptide-based calcitonin gene-related peptide receptor antagonists for the treatment of inflammatory pain; and (iii) synthesis of substituted 6-(dimethylamino)-2-phenylisoindolin-1-ones for the inhibition of luciferase.

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25

Barber, David M. "The development of nitro-Mannich/hydroamination cascades for the synthesis of substituted N-heterocycles." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:18e7c533-3789-4800-9813-1d5c7bb4e4ea.

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This thesis describes the development of nitro-Mannich/hydroamination cascade reactions for the synthesis of N-heterocycles, which are important motifs found in a variety of biologically active natural products and pharmaceuticals, such as atorvastatin (Lipitor®). Chapter 2 outlines the development of an efficient synthesis of 2,5-disubstituted pyrroles using a nitro-Mannich/hydroamination cascade. Starting from easily prepared N-protected imines and nitroalkyne substrates, a compatible combination of KOtBu (10 mol%) and AuCl3 (5 mol%) was used to afford the desired pyrrole products, after an

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26

Abe, Masahiro. "Etude de la réactivité d'ynolethers et ynamines arylogues pour des réactions d'hydroamination. Etude visant la synthèse énantiosélective de la molécule koumine." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR062.

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Le noyau pipéridine est un des motifs les plus courant dans les produits naturels et pharmaceutiques ce qui explique que la synthèse énantiosélective de piperidines polyfonctionnalisées soit un domaine particulièrement dynamique. De par sa capacité à associer une fonction amine à un groupement carbonylé, la réaction de Mannich est un outil efficace pour former une liaison C-C de manière énantiosélective tandis que la réaction d’hydroamination intramoléculaire d’alcynes est pratique pour construire des hétérocycles azotés par formation de liaisons C-N. Dans cette thèse, nous avons combiné ces d

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27

Glawar, Andreas Felix Gregor. "Design, synthesis and biological evaluation of glycosidase inhibitors in an anti-cancer setting." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:602edf26-d9ff-4fcf-8dec-c8548f3578da.

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The aim of the work described in this thesis was to explore the synthesis of glycosidase inhibitors and to evaluate their potential as anti-cancer agents. Glycosidases catalyze the fission of glycosidic bonds and are involved in vital biological functions. With regard to their potential for anti-cancer therapy, two glycosidases were identified: α-N-acetyl-galactosaminidase and β-N-acetyl-hexosaminidase. The former has been implicated in causing immunosuppression in advanced cancer patients by negating the effect of the macrophage activating factor (MAF), while the latter is secreted by invadin

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28

Eriksson, Carina. "Isolation, Synthesis and Structure-Activity Relationships of Antifeedants against the Pine Weevil, Hylobius Abietis." Doctoral thesis, Stockholm Chemical Science and Engineering, KTH, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3919.

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29

Durel, Vianney. "Développements méthodologiques de la cyclisation d’aza-Prins et aminolyse de lactone pour la synthèse de nouvelles structures peptidomimétiques- pipéridines." Thesis, Rennes 1, 2016. http://www.theses.fr/2016REN1S100/document.

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Les tétrahydropyranes et les pipéridines sont des motifs que l'on retrouve dans de nombreuses molécules naturelles bioactives. L'intérêt pour ces familles de composés ne cesse de croître. En effet le noyau pipéridine est le troisième motif cyclique le plus retrouvé dans les molécules thérapeutiques après les noyaux phényle et pyridine alors que le tétrahydropyrane prend lui la 6ème place. Il apparaît donc opportun de développer des voies d'accès simples et efficaces afin d'obtenir de façon stéréosélective (diastéréo et/ou énantiosélective) ces motifs structuraux. Les travaux de recherche prése

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30

Rosset, Isac George. "Diazocetonas α,β-insaturadas como reagentes multifuncionais: aplicação na síntese de alcaloides piperidínicos e pirrolidínicos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-20052015-101409/.

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p>O primeira parte do trabalho descreve a preparação de um novo reagente de olefinação de HWE para o preparo de diazocetonas α, β-insaturadas com geometria Z e aplicação na síntese de núcleos piperidínicos funcionalizados. Através da otimização da reação de HWE empregando o benzaldeído como aldeído padrão foi possível maximizar a obtenção do isômero Z desejado (92%, Z:E 9:1). As reações-chave para a formação dos núcleos piperidínicos foram a de olefinação de HWE utilizando amino-aldeídos, obtendo-se bons rendimentos e boa seletividade, seguida de uma reação de inserção N-H catalisad

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31

Williams, Meredith Richard Vaughan. "Sulfone-mediated synthesis of enantiopure piperidines." Thesis, Imperial College London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299202.

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32

Cariou, Claire. "Diastereoselective synthesis of 2,4,5-trisubstituted piperidines." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434701.

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33

Ferrari, Frank D. "Flexible synthesis of spirocyclic pyrans and piperidines." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/3829/.

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Spirocyclic piperidines and spirocyclic pyrans are prevalent throughout nature, often appearing in natural products which exhibit exciting biological activities. Notable examples of spirocyclic piperidine-containing biologically active natural products are halichlorine, pinnaic acid and tauropinnaic acid. Despite their structural similarity, halichlorine and the pinnaic acids were isolated from separate organisms; halichlorine was isolated from extracts of the marine sponge Halichondria okadai while both pinnaic acid and tauropinnaic acid were isolated from the Okinawan bivalve mollusc Pinna m

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34

Petrov, Ravil Rashitovich. "Part I. Application of 2-Hydroxymethylacrylic Acid, a Product of Baylis-Hillman Reaction, for the Synthesis of Novel N-backbone-to-Side-Chain Cyclic Peptide Analogs: Strategies and Side Reactions Part II. Synthesis and Biological Activities of Chimeric Bioactive Peptides Featuring Amino Acids Coupled to 4-Anilino-N-Phenethyl-Piperidine." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194330.

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During my research career in Prof. V.J.Hruby's laboratory I worked on two different projects. The first project, which was initiated by the author, was planned to serve the need of our laboratory for a novel method of peptide cyclization. This method was planned to use recent advances in Pd0-catalyzed asymmetric synthesis combined with the structural richness offered by the Baylis-Hillman chemistry which could open new ways to diverse areas of drug design, molecular immunology and chemotherapy. This approach would provide cyclic peptides featuring N-alkylated amino acids that would confer high

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35

Sadler, Matthew James. "Diastereoselective synthesis of 2,4,5 trisubstituted piperidines : application in natural product synthesis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/2901/.

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This thesis describes the diastereoselective synthesis of 2,4,5-trisubstituted piperidines using carbonyl-ene and Prins cyclisations and their application in natural product synthesis. Following on from previous work in the group, we investigated how a preinstalled substituent in the 2-position can help to control the sense of induction at the two newly forming stereocentres. We utilised the Prins reaction in the formal synthesis of pseudodistomin F, a marine alkaloid that posses a 2,4,5-tribsubstituted piperidine core. An initial first generation synthesis focused on the construction of a cyc

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36

Gandon, Lucile Alice. "A radical sterocontrolled synthesis of 2,4-disubstituted piperidines." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403012.

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37

Hutchinson, Ian Paul. "The synthesis of 3-substituted-2-(nitromethylene)-piperidines." Thesis, University of Warwick, 1994. http://wrap.warwick.ac.uk/104212/.

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The class of insecticides known collectively as the nitromethylene heterocycles (NMHs) were discovered in the late 1970's. The NMHs are a group of compounds that are particularly active against certain insects, exhibit low toxicity to vertebrates and are non-persistent in the environment. Their site of action is on the cholinergic synapse where they act as agonists at the post-synaptic nicotinic acetylcholine receptors. Research into developing these types of compounds has led to a wide range of analogues being synthesised, resulting in a wide variety of activities. Analogues of 2- (nitromethy

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Cochrane, Edward. "Synthesis of substituted piperidines using chiral organolithium chemistry." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6622/.

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Adelbrecht, Jean-Claude. "Bis (arylsulfonyl) tetrahydropyridines : application to the synthesis of piperidines." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406619.

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40

Aeyad, Tahani. "Synthesis of substituted azepanes and piperidines using organolithium chemistry." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20712/.

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α-Amino-organolithium compounds represent an important class of intermediates due to their excellent nucleophilic reactivity and importance in synthetic organic chemistry. This thesis describes some novel aspects of the n-BuLi mediated lithiation‒substitution of N-Boc heterocycles, including N-Boc-2-substituted azepane, benzazepine and piperidine derivatives.

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41

Yau, K. C. "The asymmetric synthesis of oxo-piperidines and oxo-pyrrolidines." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1451240/.

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Chapter 1 describes the attempts to synthesize piperidin-2-ones via an aza-Michael-Michael annulation, which were unsuccessful. A general route for the synthesis of piperidin-2,4-diones from β-keto esters via a Dieckmann cyclisation was proposed and five piperidin-2,4-diones with different substituents at positions-5 and -6 were prepared. An asymmetric route to 1-unsubstituted piperidin-2,4-diones was also developed which involved the use of Davies' chiral auxiliary to induce an asymmetric Michael addition. Chapter 2 describes a new approach to the synthesis of codeine. The piperidin-4-one rin

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Mathieu, Hélène. "Syntheses asymetriques de piperidines fonctionnalisees a partir d'acyloxazolidines." Paris 6, 1998. http://www.theses.fr/1998PA066231.

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Une reaction de condensation entre un aminoalcool enantiopur et un aldehyde fonctionnalise suivie d'une carbamation stereoselective a permis d'acceder a des cetooxazolidines diastereoisomeriquement pures avec un groupe tert-butoxycarbonyle comme groupe protecteur de la fonction amine. Des etudes realisees concernant la stereoselectivite de la reduction de la fonction carbonyle, placee soit en , soit en du c-2 de l'oxazolidine, ont montrees que l'induction asymetrique de la couple chirale etait plus efficace dans le cas d'un transfert de chiralite 1,2 (c = o en ) que 1,3 (c = o en ). L'obtentio

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Ravn, Jacob. "Development of privileged structure based libraries /." Måløv ; Cph. : Medicinal Chemistry Research III, Novo Nordisk A/S og Department of Medicinal Chemistry : The Danish University of Pharmaceutical Sciences, 2004. http://www.dfh.dk/phd/defences/jacobravn.htm.

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44

Wong, Yung-Sing. "Nouveaux intermediaires chiraux de type 1,4-dihydropyridine et equivalents de sels de 3,4-dihydropyridinium pour la synthese asymetrique de piperidines polysubstituees. Application a la synthese enantioselective du 3-ppp et de l'indolizidine 195b." Paris 11, 1994. http://www.theses.fr/1994PA112105.

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L'application de la reaction de zincke a des amines primaires enantiomeriquement pures a donne des sels de pyridinium portant un centre asymetrique directement fixe sur l'azote, a partir de la pyridine correspondante, substituee ou non en position 3. L'etude de la reduction par le dithionite de sodium de ces sels a conduit de maniere efficace a de nouveaux intermediaires 1,4-dihydropyridines chiraux. La reduction des sels n-substitues par une chaine phenylethanol donne des 1,4-dihydropyridines qui s'isomerisent en 3,7,8,8a-tetrahydro-2h-oxazolo3,2-apyridines. Une etude structurale a ete entrep

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Mancey, Nicole Claire. "Investigations Intro [3+3] Cycloadditions for the synthesis of piperidines." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522345.

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Goldspink, Nicholas J. "Asymmetric synthesis of piperidines using the chiral lithium amide base approach." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364649.

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Hunter, Darren F. A. "Synthesis of bioactive pyrrolidine and piperidinone derivatives from carbohydrates." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418528.

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Stapper, Christian. "Ringumlagerungen und Synthese von Piperidin- und Pyrrolidinalkaloiden durch Olefinmetathese." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962764485.

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Haji-Cheteh, Chehasnah. "Synthesis of phosphine-alkene ligands and 3-hydroxy piperidines using organolithium chemistry." Thesis, University of York, 2016. http://etheses.whiterose.ac.uk/13889/.

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Abstract:

This thesis describes synthetic routes to P-stereogenic phosphine-alkene ligands and 3-hydroxy piperidines containing heteroaromatics via lithiation-trapping of phosphine boranes or N-Boc pyrrolidine. Both topics are introduced in chapter 1.Chapter 2 presents a route to a new type of P-stereogenic phosphine-alkene ligand B prepared by racemic lithiation of t-butyldimethylphosphine borane or dimethylphenylphosphine borane using s-BuLi. Different allylic halides were used to trap the lithiated intermediate to give chiral alkene-phosphine boranes A. In chapter 3, 3-hydroxy piperidines were synthe

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CARBONNEL, SYLVIE. "Syntheses stereoselectives de piperidines polysubstituees d'interet biologique derivees de l'acide pipecolique." Clermont-Ferrand 2, 2001. http://www.theses.fr/2001CLF22273.

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Abstract:

Ce travail decrit une nouvelle methode d'acces a des composes piperidiniques derives de l'acide pipecolique. Une reaction de cyclisation intramoleculaire de type mannich, impliquant un aldehyde et une beta-aminocetone protegee, permet la creation du cycle piperidinique. La fonction ester peut etre introduite sur ce cycle par l'intermediaire de l'un ou l'autre des precurseurs et les deux voies de synthese correspondantes ont ete mises au point. La premiere voie fait intervenir un ester glyoxylique et une beta-aminocetone protegee alpha-alkylee. La diastereoselectivite de la reaction est alors s

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