Relevant bibliographies by topics / Piperidone

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Piperidone'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Piperidone"

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Romero-Ibañez, Julio, Marina A. Ortega-Rojas, Jonathan R. Valdéz-Camacho, Luis G. Hernández-Vázquez, Fernando Sartillo-Piscil, and Jaime Escalante. "Asymmetric Synthesis of trans-3-Alkoxyamino-4-Oxygenated-2-Piperidones Mediated by Transition-Metal-Free Dual C-H Oxidation and Its CAL-B-Assisted Enzymatic Resolution." Catalysts 13, no. 4 (2023): 703. http://dx.doi.org/10.3390/catal13040703.

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A general chemo-enzymatic approach to synthesize both enantioenriched trans-3-alkoxyamino-4-oxy-2-piperidones, which are important scaffold for various naturally occurring alkaloids, is reported. To this end, a selective transition-metal-free dual C−H oxidation of piperidines mediated by the TEMPO oxoammonium cation (TEMPO+) was used, followed by enzymatic resolution of the corresponding alkoxyamino-2-piperidones with Candida antarctica lipase (CAL-B), to yield the title compounds in high enantiomeric excess (ee). The absolute configuration of both enantioenriched compounds was determined usin
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Holzgrabe, Ulrike, Willy Friedrichsen, and Karl-F. Hesse. "Keto-Enol-Tautomerism and Configurational Isomerism of 2,6-Disubstituted 4-Piperidone-3,5-dicarboxylates." Zeitschrift für Naturforschung B 46, no. 9 (1991): 1237–50. http://dx.doi.org/10.1515/znb-1991-0918.

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The dialkyl 2,6-dialkylsubstituted 4-piperidone-3,5-dicarboxylates were synthesized by a Mannich procedure. Depending on the substitution at the nitrogen keto-enol-tautomerism and a configurational isomerism at C 2 is observed. The structure of the N-substituted piperidone 24 E (C18H29NO5) has been determined by X-ray analysis: it is characterized by an enol structure of the β-ketoester and an axial position of the alkyl group at C 2 and an equatorial one of the alkyl group at C 6. The O–H···O hydrogen bond shows characteristic values of a strong hydrogen bond. The N-unsubstituted piperidones
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K. Anuja and Nashwa K. K. "Innovative piperidone derivatives: a new horizon in Potent anticancer therapeutics." International Journal of Allied Medical Sciences and Clinical Research 12, no. 3 (2024): 354–62. https://doi.org/10.61096/ijamscr.v12.iss3.2024.354-362.

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Recent advancements in the synthesis and evaluation of piperidone derivatives have unveiled their remarkable potential as potent anticancer agents. This review highlights the innovative approaches and significant findings in the development of novel piperidone-based compounds, showcasing their efficacy against various cancer cell lines. Among the noteworthy compounds, dissymmetric 3,5-bis(arylidene)-4-piperidones (BAPs) have demonstrated selective cytotoxicity with minimal impact on normal cells. Further, modifications involving N-benzoylation, N-benzenesulfonylation and N-acryloylation have e
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Sartillo-Piscil, Fernando, Julio Romero-Ibañez, Silvano Cruz-Gregorio, and Leticia Quintero. "Concise and Environmentally Friendly Asymmetric Total Synthesis of the Putative Structure of a Biologically Active 3-Hydroxy-2-piperidone Alkaloid." Synthesis 50, no. 15 (2018): 2878–86. http://dx.doi.org/10.1055/s-0037-1610089.

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An asymmetric total synthesis of stereoisomers of a putative structure of 3-hydroxy-2-piperidone alkaloid derivative is described. This route is not only concise and efficient but also is achieved under an environmentally friendly approach. To this end, a direct and double C–H oxidation reaction of simple benzylated piperidine and Baker’s yeast reduction of a carbonyl group allowed the rapid access to the optically enriched (S)-1-benzyl-3-hydroxy-2-piperidone in only three steps. The NMR data agreed with those obtained in the first total synthesis (and in discrepancy with the natural product),
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Hieu, Truong Hong, Le Tuan Anh, Anatoly T. Soldatenkov, Nadezhda M. Kolyadina, and Victor N. Khrustalev. "Dimethyl 2-[24-acetyl-28-oxo-8,11,14-trioxa-24,27-diazapentacyclo[19.5.1.122,26.02,7.015,20]octacosa-2,4,6,15(20),16,18-hexaen-27-yl]but-2-enedioate." Acta Crystallographica Section E Structure Reports Online 68, no. 8 (2012): o2431—o2432. http://dx.doi.org/10.1107/s1600536812030644.

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The title compound, C31H34N2O9, is a product of the Michael addition of the cyclic secondary amine subunit of the (bispidino)aza-14-crown-4 ether to dimethyl acetylenedicarboxylate. The molecule comprises a tricyclic system containing the aza-14-crown-3 ether macrocycle and two six-membered piperidinone rings. The aza-14-crown-3-ether ring adopts a bowl conformation with a dihedral angle between the planes of the fused benzene rings of 51.14 (5)°. The central piperidone ring has a boat conformation, whereas the terminal piperidone ring adopts a chair conformation. The dimethyl ethylenedicarbox
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(MRS.), KR. MEENAL, and D. VIMALA DEVI (MRS.). "A Study of Conformational Effects on Oxidation Kinetics of N-H- and N-Methyl-4-piperidones with N-Bromosuccinimide : A Comparative Analysis." Journal of Indian Chemical Society Vol. 73, Aug 1996 (1996): 391–96. https://doi.org/10.5281/zenodo.5897413.

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Department of Chemistry, Seethalakshmi Ramaswami College (Autonomous), Trichy-620 002 <em>Manuscript received 26 March 1993, revised 25 October 1994, accepted 18 January 1995</em> A comparative oxidation kinetics of six pairs of<em> N</em>-H and .V-methyl-2,6-diphenyl-4-piperidones with <em>N</em>-bromosuccinimide (NBS) in aqueous acetic acid medium (20-80%, v/v) at constant ionic strength in presence or mercuric acetate has been investigated. The effect of alkyl substituents on the rates or oxidation in <em>N</em>-H&nbsp;series parallels their effects in <em>N</em>-H series. The enhanced rate
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Prisyazhnyuk, Vladimir, Matthias Jachan, Irene Brüdgam, Reinhold Zimmer та Hans-Ulrich Reissig. "Addition of lithiated methoxyallene to aziridines – a novel access to enantiopure piperidine and β-amino acid derivatives". Collection of Czechoslovak Chemical Communications 74, № 7-8 (2009): 1069–80. http://dx.doi.org/10.1135/cccc2009012.

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Addition of lithiated methoxyallene to aziridine derivatives provided the expected primary addition products. The less substituted carbon of the aziridine ring was attacked selectively. The primary adducts could be converted to enantiopure piperidine derivatives or β-amino acid derivatives. The unexpected reactions lead to a tricyclic sulfonamide and to alkynyl-substituted aminoethers. The efficient two-step conversion of a piperidone derivative to a benzomorphan demonstrates the potential of this approach to biologically active compounds.
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Méndez, Leonor, and Vladimir Kouznetsov. "Intramolecular N to N acyl migration in conformationally mobile 1′-acyl-1-benzyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinoline] systems promoted by debenzylation conditions (HCOONH4/Pd/C)." Open Chemistry 9, no. 5 (2011): 877–85. http://dx.doi.org/10.2478/s11532-011-0082-y.

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AbstractWe report an efficient and useful synthesis of new attractive spiropiperdine scaffolds 4 based on an intramolecular acyl transfer process in 1′-acyl-1-benzyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinolines] 3 using simple and mild debenzylation reaction conditions (HCOONH4/Pd/C). The compounds 3 were prepared by acylating 1-benzyl-4′-methyl-3′,4′-dihydro-1′H-spiro[piperidine-4,2′-quinolines] 2 that are easily available from 1-benzyl-4-piperidone 1. The intramolecular character of this process was proven primarily through a crossover experiment technique. Through an examination of al
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Eryanti, Yum, Rudi Hendra, Tati Herlina, Adel Zamri, and Unang Supratman. "Synthesis of N-methyl-4-piperidone Curcumin Analogues and Their Cytotoxicity Activity against T47D Cell Lines." Indonesian Journal of Chemistry 18, no. 2 (2018): 362. http://dx.doi.org/10.22146/ijc.24174.

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Three piperidone curcumin analogues (N-methyl-(3E,5E)-3,5-bis-(2-chlorobenzylidene)-4-piperidone (1), N-methyl-(3E,5E)-3,5-bis-(3-bromobenzylidene)-4-piperidone (2) and N-methyl-(3E,5E)-3,5-bis-(4-chlorobenzylidene)-4-piperidone (3)) were synthesized from N-methyl-4-piperidone with halogenbenzaldehyde, 2-chlorobenzaldehyde, 3-bromobenzaldehyde and 4-chlorobenzaldehyde. The Claisen-Schmidt condensation reaction was used in alkali condition with combinatorial. All the compounds showed light yellow needle, light yellow powder, and yellow crystal form with percentage of yield 39, 66, and 40%, resp
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Li, Ning, Xianyong Bai, Lianshuang Zhang, and Yun Hou. "Synthesis, crystal structures and anti-inflammatory activity of four 3,5-bis(arylidene)-N-benzenesulfonyl-4-piperidone derivatives." Acta Crystallographica Section C Structural Chemistry 74, no. 10 (2018): 1171–79. http://dx.doi.org/10.1107/s2053229618013232.

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3,5-Bis(arylidene)-4-piperidone (BAP) derivatives display good antitumour and anti-inflammatory activities because of their double α,β-unsaturated ketone structural characteristics. If N-benzenesulfonyl substituents are introduced into BAPs, the configuration of the BAPs would change significantly and their anti-inflammatory activities should improve. Four N-benzenesulfonyl BAPs, namely (3E,5E)-1-(4-methylbenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)benzylidene]piperidin-4-one dichloromethane monosolvate, C28H21F6NO3S·CH2Cl2, (4), (3E,5E)-1-(4-fluorobenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)b
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Dissertations / Theses on the topic "Piperidone"

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Lewis, Neil. "Asymmetric piperidine synthesis." Thesis, University of Nottingham, 1995. http://eprints.nottingham.ac.uk/13293/.

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It has been demonstrated that bakers' yeast reduction of 1-tert-butyl-2-methyl 3-oxo-piperidine-1,2-dicarboxylate gives (2R, 3S), 1-tert-butyl-2-methyl 3-hydroxy-piperidine-1,2-dicarboxylate in 80% chemical yield with >99% d.e. and >97% e.e. Also bakers' yeast reduction of 1-tert-butyl-3-ethyl 4-oxo-piperidine-1,3-dicarboxylate gives (3R, 4S), 1-tert-butyl-3-ethyl4-hydroxy-piperidine-1,3-dicarboxylate in 74% chemical yield with >99% d.e. and >93% e.e. The optical purity and absolute configurations of the hydroxy-ester derivatives were determined by conversion into the corresponding chiral bis-
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Turner, Ian. "Piperidines from tetrahydroimidazoles." Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334848.

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Taylor, Sarah Alison. "Sulfur-mediated pyrrolidine and piperidine synthesis." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613286.

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Adriaenssens, Louis. "Stereoselective synthesis of piperidines." Thesis, Connect to e-thesis to view edited abstract. Move to record for print version, 2008. http://theses.gla.ac.uk/49/.

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Girling, Paul Ricardo. "Novel approaches to piperidine and hydropyridine derivatives." Thesis, Durham University, 2012. http://etheses.dur.ac.uk/6354/.

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Three new modes of reactivity are reported between the reaction of an imine, but-3-en-2-ones and a Lewis acid. These are formal [2+2+2]-, [1+2+1+2]- and [4+2]- cycloadditions, deriving 1,1'-(1,2-dihydropyridine-3,5-diyl)diethanones, 1,1'-(1,4-dihydropyridine-3,5-diyl)diethanones and piperidin-4-ones and respectively. The [2+2+2]- and [1+2+1+2]-cycloadditions proceed when R3 = LG (leaving group), with the [1+2+1+2]-pathway dominating when the imine is easily hydrolysed within the reaction conditions. When R3 ≠ LG, the cycloaddition proceeds through different [4+2]-mechanistic pathways, dependen
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Adams, David Roger. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Exeter, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236570.

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Mosts, R. C. "Studies in the synthesis of piperidine alkaloids." Thesis, University of Essex, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379495.

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Eskici, Mustafa. "Asymmetric piperidine synthesis via 1,3-cyclic sulfates." Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368215.

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Woods, Gordon Alexander. "Synthetic approaches to functionalised piperidines." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:4c6fdb6c-c021-447c-8fc9-35241b552850.

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This thesis is concerned with the synthesis of functionalised piperidines. The piperidine unit is found in numerous alkaloids and other natural products, and has also been incorporated into synthetic compounds of significant therapeutic or strategic synthetic potential. Although numerous syntheses of individual piperidine compounds have been published, there are few general routes to this class of compounds, and there is therefore a need for such routes to be developed. Bicyclic lactams derived from (S)-pyroglutamic acid have been shown to be useful synthons in the synthesis of pyrrolidines. A
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Ottersbach, Dirk. "Dehydrierung n-substituierter Delta3-Piperideine /." [S.l. : s.n.], 1988. http://www.gbv.de/dms/bs/toc/025230328.pdf.

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Books on the topic "Piperidone"

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Rubiralta, Mario. Piperidine: Structure, preparation, reactivity, and synthetic applications of piperidine and its derivatives. Elsevier, 1991.

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Williams, Jodi Thomas. Stereoselective piperidine synthesis via ene and carbonyl ene cyclisations. University of Birmingham, 2003.

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Hutchinson, Ian. The synthesis of 3-substituted-2-(nitromethylene)-piperidines. typescript, 1994.

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Oetting, Jörg. Optisch aktive [beta]-Hydroxy-carbonsäuren [Beta-Hydroxy-carbonsäuren] als Bausteine für neue Amino-hydroxy-carbonsäuren und Piperidin-Alkaloide: Stereoselektive Totalsynthese von (-)-Cassin. [s.n.], 1995.

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C, Heading R., and Wood Jack D, eds. Gastrointestinal dysmotility: Focus on cisapride. Raven Health Care Communications, 1992.

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Rubiralta, Mario. Piperidine. Elsevier, 1991.

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Vardanyan, Ruben. Piperidine-Based Drug Discovery. Elsevier, 2017.

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Vardanyan, Ruben. Piperidine-Based Drug Discovery. Elsevier, 2017.

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Piperidine - Structure, Preparation, Reactivity, and Synthetic Applications of Piperidine and its Derivatives. Elsevier, 1991. http://dx.doi.org/10.1016/c2009-0-12882-9.

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Rubiralta, M., E. Giralt, and A. Diez. Piperidine: Structure, Preparation, Reactivity, and Synthetic Applications of Piperidine and Its Derivatives. Elsevier Science & Technology Books, 2013.

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Book chapters on the topic "Piperidone"

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Wohlfarth, Ch. "Second virial coefficient of poly(1-vinyl-2-piperidone)." In Polymer Solutions. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-02890-8_748.

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Gooch, Jan W. "Piperidine." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_8770.

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Lide, David R. "Piperidine." In Handbook of Organic Solvents. CRC Press, 2024. http://dx.doi.org/10.1201/9781003575191-397.

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Howard, Philip H., Gloria W. Sage, William F. Jarvis, and D. Anthony Gray. "Piperidine." In Handbook of Environmental Fate and Exposure Data For Organic Chemicals, Volume II. CRC Press, 2023. http://dx.doi.org/10.1201/9781003418863-58.

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Schomburg, Dietmar, and Dörte Stephan. "Piperidine N-piperoyltransferase." In Enzyme Handbook 11. Springer Berlin Heidelberg, 1996. http://dx.doi.org/10.1007/978-3-642-61030-1_275.

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Wohlfarth, Ch. "Viscosity of piperidine." In Supplement to IV/18. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75486-2_159.

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Demaison, J. "573 C5H11N Piperidine." In Asymmetric Top Molecules. Part 2. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-10400-8_321.

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Li, Jie Jack, and Minmin Yang. "Spirocyclic Piperidines." In Drug Discovery with Privileged Building Blocks. CRC Press, 2021. http://dx.doi.org/10.1201/9781003190806-28.

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Wohlfarth, Ch. "Surface tension of piperidine." In Supplement to IV/16. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75508-1_101.

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Li, Jie Jack, and Minmin Yang. "Piperidine, the Enchanted Ring." In Drug Discovery with Privileged Building Blocks. CRC Press, 2021. http://dx.doi.org/10.1201/9781003190806-19.

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Conference papers on the topic "Piperidone"

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Peterson, Burl H., Sergey S. Sarkisov, V. N. Nesterov, et al. "New derivatives of cyclohexanone and piperidone compounds for bioluminous sensing." In Biomedical Optics 2006, edited by Samuel Achilefu, Darryl J. Bornhop, and Ramesh Raghavachari. SPIE, 2006. http://dx.doi.org/10.1117/12.641751.

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Sridevi, C., G. Velraj, R. Palanivel, P. M. Champion, and L. D. Ziegler. "Vibrational Spectroscopic Studies and DFT calculations of 2, 6 Diphenyl 4 Piperidone." In XXII INTERNATIONAL CONFERENCE ON RAMAN SPECTROSCOPY. AIP, 2010. http://dx.doi.org/10.1063/1.3482829.

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Soong, Rueyshyang. "Abstract 4654: A novel proteasome inhibitor, bis-Benzylidine Piperidone (RA190), control hepatocellular carcinoma effectively through inhibiting STAT3." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-4654.

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Standing, David, Jake New, Prasad Dandawate, et al. "Abstract 5862: 3,5-bis(2,4-difluorobenzylidene)-4-piperidone, a novel compound potently inhibits HNSCC through a DCLK1 mediated mechanism." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5862.

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Kuppusamy, Periannan, K. Selvendiran, L. Tong, et al. "Abstract 5470: Safe and targeted anticancer therapeutic efficacy of a novel antioxidant-conjugated difluoro-diarylidenyl-piperidone (HO-3867) against ovarian cancer." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-5470.

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Craig, Norman, Alberto Lesarri, Emilio Cocinero, Patricia Ecija, Heinz Rudolph, and Jean Demaison. "EQUILIBRIUM STRUCTURE OF PIPERIDINE." In 69th International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2014. http://dx.doi.org/10.15278/isms.2014.wj12.

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Kovačková, Soňa, Martin Dračínský, and Dominik Rejman. "Piperidine nucleoside phosphonic acid derivatives." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112372.

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Malmakova, A., N. Kystaubayeva, T. Zharkinbek, M. Myrzakhanov, M. Balabekova та V. Yu. "Piperidine-containing phosphonates as immunоcorrectors". У 6TH INTERNATIONAL CONFERENCE ON ENVIRONMENT (ICENV2018): Empowering Environment and Sustainable Engineering Nexus Through Green Technology. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5117135.

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Okeke, Micheal, and Dong-Sheng Yang. "VIBRONIC SPECTRA OF GROUP 13 METAL-PIPERIDINE COMPLEXES." In 2021 International Symposium on Molecular Spectroscopy. University of Illinois at Urbana-Champaign, 2021. http://dx.doi.org/10.15278/isms.2021.tl10.

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Muliadi and Muhammad Nurdin. "Terbium piperidine dithiocarbamate with 2.2’ dimethyl-1.10 phenanthroline co-ligand." In 5TH INTERNATIONAL CONFERENCE ON ELECTRICAL, ELECTRONIC, COMMUNICATION AND CONTROL ENGINEERING (ICEECC 2021). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0137981.

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Reports on the topic "Piperidone"

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Banks, Harold D. Piperidine Synthesis. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada258925.

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Miranda, P. Mechanism of hydrodenitrogenation adsorption of piperidine on reduced molybdenum catalysts. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/7275171.

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Miranda, P. Mechanism of hydrodenitrogenation adsorption of piperidine on reduced molybdenum catalysts. Tenth quarterly report, January 1--March 31, 1992. Office of Scientific and Technical Information (OSTI), 1992. http://dx.doi.org/10.2172/10167178.

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