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Dissertations / Theses on the topic 'Pituitary gland Pituitary Gland, Anterior'

Author: Grafiati

Published: 4 June 2021

Last updated: 7 February 2022

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1

Shale, J. A. "Vasoactive intestinal polypeptide in the chicken anterior pituitary gland." Thesis, University of Edinburgh, 1998. http://hdl.handle.net/1842/26925.

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Vasoactive intestinal polypeptide was shown to be present in the chicken anterior pituitary gland using high performance liquid chromatography (HPLC), radioimmunoassay (RIA) and immunocytochemistry. The VIP antibodies used for both RIA and immunocytochemistry showed no cross reaction with any known VIP-like peptides, including pituitary adenylate cyclase activating polypeptide (PACAP). VIP mRNA was also shown to be present in anterior pituitary gland. Two VIP-immunoreactive cell (VIP-ir) types were found throughout the cephalic and caudal lobes of the anterior pituitary gland. The morphologica

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2

Deeb, Asma. "The regulation of somatotroph function by growth hormone releasing hormone and its receptor in vitro." Thesis, University of Newcastle upon Tyne, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246715.

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3

McFerran, Brian William. "An investigation into the mechanisms mediating calcium ion-stimulated ACTH secretion from AtT-20 anterior pituitary tumour cells." Thesis, University of St Andrews, 1996. http://hdl.handle.net/10023/14880.

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The mouse AtT-20/D16-16 anterior pituitary tumour cell line was employed as a model system for the study of the mechanisms mediating calcium ion-stimulated adrenocorticotropin (ACTH) secretion. The present study indicates that calcium ion-stimulated ACTH secretion from AtT-20 cells is mediated by a GTP-binding protein which is present in a variety of other cell types and has been dubbed Ge (for reviews see Gomperts, 1990; Lindau & Gomperts, 1991). In AtT-20 cells the nature of Ge remains elusive with the selective heterotrimeric GTP-binding protein activator AIF(3-5) proving not to be a useful

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4

Lewis, C. E. "Factors involved in control of gonadotrophin secretion by the anterior pituitary gland." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375271.

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5

Porter, Duncan William Fulton. "Neuropeptide regulation of hormone secretion from the anterior pituitary gland of the ewe." Thesis, University of Edinburgh, 1991. http://hdl.handle.net/1842/20116.

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The actions of LHRH, CRH and NPY on the activity of the reproductive axis and, in particular, the LHRH pulse generator were investigated <i>in vivo</i>. A model was developed to allow direct administration of neuropeptides, antagonists and antibodies into the third cerebral ventricle of conscious, free-movingand unstressed sheep, giving access to hypothalamic periventricular structures involved in the control of the anterior pituitary gland. Plasma levels of OH were used as a measure of LHRH pulsatility. Three major questions were addressed: (1) Does hypothalamic LHRH autoregulate its own rele

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6

Marsden, Claire Lisa. "The regulation of luteinising hormone production in the anterior pituitary gland of domestic fowl." Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283755.

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7

Jones, Philip Melvyn. "The influence of hormonal status on the production of pituitary minority peptides : investigation of an autocrine-paracrine system in the rat anterior pituitary gland." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46373.

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8

Kelley, Jennifer Caitlin. "Effects of Estrogen and Progesterone on the Sensitivity of the Anterior Pituitary Gland and Hypothalamus in Prepubertal Rats: Role of Nitric Oxide and Dopamine." Miami University Honors Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1114785173.

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9

Muchow, Michael Robert. "Identification of a single nucleotide polymorphism associated with adiposity following transcriptional profiling of gene expression in the anterior pituitary gland." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3798.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Molecular and Cell Biology. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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10

Szeto, Daniel Pit Tat. "The role of the bicoid related homeodomain factor, P-OTX, in the development of anterior pituitary gland and limb-type identity /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9904828.

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11

Shamgochian, Maureen. "The Stimulation of Luteinizing Hormone Secretion from Anterior Pituitary Cells in Culture by Substance P: A Dissertation." eScholarship@UMMS, 1990. https://escholarship.umassmed.edu/gsbs_diss/129.

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The observations that substance P (SP) is localized in the anterior pituitary gland (AP) and is regulated by the hormonal status of the animal, as well as the demonstration of SP binding sites in the AP, have led to the idea that SP may participate in the regulation of AP function. Numerous and sometimes contradictory reports of SP effects on AP hormone secretion, particularly on luteinizing hormone (LH), left the question of whether SP acts directly at the level of the AP to regulate LH secretion still unanswered. To investigate a possible physiological function of SP in the AP, the effects o

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12

Ogawa, Shuichiro. "Abundant expression of the membrane-anchored protease-regulator RECK in the anterior pituitary gland and its implication in the growth hormone/insulin-like growth factor 1 axis in mice." Kyoto University, 2020. http://hdl.handle.net/2433/254494.

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13

Gordon-Weeks, R. "Neurophisins precursors in the posterior pituitary gland." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38020.

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14

McKlveen, Tori Leigh. "Evaluation of the Normal Equine Pituitary Gland." Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/10156.

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Computed tomography (CT) is becoming more available as a diagnostic tool in the evaluation of the equine skull and brain. Objectives of this study were: 1) refine a CT protocol for evaluating the equine pituitary gland, 2.) define the CT anatomy of the pituitary region, 3.) determine a set of normal values for the pituitary dimensions (length, width, height, volume and weight), 4.) refine CT techniques for measuring pituitary size. Horses were scanned using 10x10mm, 10x5mm, 4x4mm and 4x2mm slice thickness and interval combinations. The pituitary glands were removed immediately after CT and gr

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15

Reyes, Rodríguez Ricardo. "Development and Differentiation of the Vertebrate Pituitary Gland." Diss., University of La Laguna, 2002. http://hdl.handle.net/10919/71542.

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A detailed study was made in this doctoral thesis on the development and differentiation of the vertebrate pituitary gland, with the aim to establish a fate map in Rathke's pouch of the origin of different hormone producing cells present in the adult pituitary gland, that explain if the differences observed in the distribution pattern of different hormone producing cells in the adult is the consecuence of differences in their development. For this reason, the study was made in two vertebrate groups, Mammals and Avian, that present notable differences in their hormone producing cell distributio

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16

Moore, S. E. H. "Biochemical aspects of neurosecretion in the posterior pituitary gland." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375290.

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17

Chandwani, Paul. "A study of the developing pituitary gland in zebrafish." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399759.

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18

Krishnamurthy, Divya. "Analysis of the human pituitary gland in psychiatric disorders." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609379.

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19

Sarri, Stephanie. "The seasonal regulation of prolactin in the pituitary gland." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-seasonal-regulation-of-prolactin-in-the-pituitary-gland(ba545226-bbc9-47a6-8bfd-a294cd7aec47).html.

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For many species, adaptation of various physiological characteristics to the seasonally changing environment is vital in their survival and reproductive fecundity. Such seasonal alterations in physiology can affect growth, food intake, energy balance and gonadal activity, as well as the secretion of the pituitary hormone prolactin. The current suggested model of seasonal prolactin regulation dictates that the melatonin-responsive pars tuberalis (PT) of the anterior pituitary gland translates the photoperiodic input (measurement of day length) into a seasonal signal, which controls prolactin re

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20

Lange, Jeremy David. "The effect of anti-malarial drugs on the pituitary gland." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238726.

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21

Hu, Guangfu, and 呼光富. "Novel pituitary actions of TAC3 gene products in grass carp." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208050.

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22

Schang, Anne-Laure. "Codes transcriptionnels et expression du gène du récepteur de la GnRH au cours du développement et chez l’adulte." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T022/document.

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Le récepteur hypophysaire de la GnRH (RGnRH) joue un rôle crucial dans le contrôle de la fonctionde reproduction. Dans le promoteur distal du Rgnrh, j’ai caractérisé un élément de réponsebifonctionnel répondant aux protéines LIM à homéodomaine ISL1/LHX3 et à GATA2. D’autre part,deux motifs TAAT situés dans la région plus proximale confèrent à ce gène la capacité de répondreaux facteurs Paired-like PROP1 et OTX2. Tous ces facteurs, exprimés précocement au cours del’ontogenèse hypophysaire, pourraient participer à l’émergence de l’expression du Rgnrh. Hors del’hypophyse, j’ai découvert que le Rg

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23

Moore, Heather Corrina. "Genetic Profiling of the Bovine Pituitary Gland Using cDNA Microarray Technology." Diss., The University of Arizona, 2006. http://hdl.handle.net/10150/194108.

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Goals of this dissertation were to 1) use custom-made cDNA microarrays to identify genes in the bovine pituitary gland that are differentially expressed during the estrous cycle and 2) characterize their patterns of gene expression. The estrous cycle is a dynamic process that requires coordination between the hypothalamus, pituitary gland, and ovaries. The anterior pituitary gland synthesizes and secretes the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), which regulate steroidogenesis and follicular development. Currently, intrapituitary factors that modulate

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24

Stallings, Caitlin. "Forkhead Factors FOXO1 and FOXO3 in Pituitary Gland Development and Function." OpenSIUC, 2019. https://opensiuc.lib.siu.edu/dissertations/1763.

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The differentiation of growth hormone producing somatotropes in the pituitary gland is dependent upon signaling and transcription factors produced both within and outside the gland. In order to better understand this fundamental process, we have focused on investigating the contribution of forkhead factors FOXO1 and FOXO3. We sought to elucidate whether FOXO1 is sufficient to drive somatotrope differentiation in an over-expression mouse model, identify potential functional redundancy between closely related forkhead family members, and to specify the genetic targets of FOXO1 binding in the pit

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25

Rosenberg, Lewis A. "CYSTIC FIBROSIS IN MICE ELICITS MULTIPLE CHANGES IN PITUITARY GLAND FUNCTION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1127498814.

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26

Matasconi, Manuela. "Pituitary regulation of plasma lipoprotein metabolism and intestinal cholesterol absorption /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-571-2/.

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27

Saunders, Susie K. "Altered poshphorylation of [beta]-catenin in glucocorticoid treated 235-1 rat pituitary tumor cells." Huntington, WV : [Marshall University Libraries], 2004. http://www.marshall.edu/etd/descript.asp?ref=432.

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28

Nye, Elisabeth Jane. "Dynamic stimulation tests in the assessment of hypothalamic-pituitary-adrenal axis function in pituitary disease and obesity /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17166.pdf.

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29

Kavanagh, Emma. "Effect of thyroid hormones on apoptosis and mitosis in the pituitary gland." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390107.

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30

Ploegman, Adam. "The Role of the Forkhead Transcription Factor FOXM1 in Pituitary Gland Development." OpenSIUC, 2011. https://opensiuc.lib.siu.edu/theses/762.

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AN ABSTRACT OF THE THESIS OF Adam G. Ploegman, for the Master of Science degree in Physiology, presented on July 12, 2011, at Southern Illinois University Carbondale. TITLE: THE ROLE OF THE FORKHEAD TRANSCRIPTION FACTOR FOXM1 IN PITUITARY GLAND DEVELOPMENT MAJOR PROFESSOR: Dr. Buffy Ellsworth The purpose of this project was to investigate the role of FOXM1 in pituitary gland development. FOXM1 is a member of the forkhead transcription factor family and is expressed in the developing pituitary. FOXM1 is expressed in proliferating cells in many tissues. We hypothesize that FOXM1 is

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31

Krown, Kevin Alan. "Pituitary changes in force-molted hens." Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185205.

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The effect of forced molt on pituitary function and other endocrine parameters was investigated in three year old hens subjected to a dietary forced molting procedure. In addition to molting, fasting caused cessation of egg production, body and organ weight loss, alterations in hormone secretion and morphological changes in some endocrine glands. Body and ovary weights decreased but returned to normal with ad libitum feeding. Pituitary, thyroid and adrenal weights were not affected but serum hormone levels measured by RIA revealed a decrease in LH, FSH and PRL and increases in TSH, T₃ and GH a

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32

Kapali, Jyoti. "DELETION OF THE Foxo1 GENE IN MOUSE PITUITARY GLAND AND THE EFFECTS ON SOMATOTROPE DIFFERENTIATION AND FUNCTION." OpenSIUC, 2017. https://opensiuc.lib.siu.edu/dissertations/1485.

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Various mouse models have allowed for identification of several transcription factors that are necessary for pituitary development. Lesions in the transcription factor genes result in pituitary hormone deficiency. Hormone deficiencies occur in approximately one in 4000 live births. Pituitary hormone deficiency may occur due to loss of a single hormone causing isolated hormone deficiency or several hormones leading to combined pituitary hormone deficiency (CPHD). Defects in genes such as LHX3, LHX4, RPX, PROP1, and PIT1 are known to contribute to CPHD in humans. FOXO1 is a member of a large fam

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33

Fung, Sai-kit, and 馮世傑. "Functional studies of pituitary activin/follistatin system in grass carp." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hdl.handle.net/10722/192776.

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34

Kozhemyakina, Elena A. "The role of the Rx homeobox gene in development of the eye and pituitary gland." Morgantown, W. Va. : [West Virginia University Libraries], 2005. https://etd.wvu.edu/etd/controller.jsp?moduleName=documentdata&jsp%5FetdId=3959.

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Thesis (Ph. D.)--West Virginia University, 2005.<br>Title from document title page. Document formatted into pages; contains viii, 179 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 156-179).

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35

Jenkins, Sultan Ali. "Characterization of glucocorticoid-induced changes in gene expression in the embryonic pituitary gland." College Park, Md. : University of Maryland, 2006. http://hdl.handle.net/1903/3508.

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Thesis (Ph. D.) -- University of Maryland, College Park, 2006.<br>Thesis research directed by: Animal Sciences. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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36

Duthie, Sarah MacDonald. "Molecular cloning and characterisation of G-protein-coupled receptors from the pituitary gland." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20489.

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This thesis describes molecular cloning and characterisation studies of two G-protein coupled receptors (GPRs), the thyrotrophin-releasing hormone receptor (TRH-R) and the dopamine D2 receptor. Sequence analysis identified the clone as a TRH-R encoding a putative protein of 398 amino acids. The human pituitary TRH-R had high sequence homology with the rat and mouse TRH-Rs, except at the 3' end of the carboxy (COOH) tail. In this region, residue 392 is a common point of sequence divergence, after which the human, rat and mouse TRH-Rs encode variant amino acids. The COOH tail of GPRs has been im

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37

Adetoye, Mercy A. "Regulation of photoperiodic prolactin secretion the possible roles of the pars tuberalis and tachykinins /." Laramie, Wyo. : University of Wyoming, 2009. http://proquest.umi.com/pqdweb?did=2065701641&sid=1&Fmt=2&clientId=18949&RQT=309&VName=PQD.

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38

Martens, Susanne. "Genetische Varianten in BMP2, BMP4 und BMP7 bei Patienten mit angeborener Hypophyseninsuffizienz." Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-147939.

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Die Entwicklung der Hypophyse ist ein komplexer Prozess, an dem viele Transkriptionsfaktoren beteiligt sind. Bedeutende Funktionen haben die Bone Morphogenetic Proteins 2, 4 und 7. Ziel der Arbeit war es, an Patienten mit angeborener kombinierter Hypophyseninsuffizienz diese 3 Gene auf Mutationen zu untersuchen. Dabei wurden die Exons, Exon-Intron-Übergänge sowie die 3`- und 5`-untranslatierten Regionen sequenziert. Neu identifizierte Varianten wurden anschließend in einer gesunden Kontrollkohorte untersucht, um pathogenetisch nicht relevante Genvarianten auszuschließen. Um die funktionelle Re

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39

Gilbert, Tanya. "Somatotroph regulation in dwarf rats." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322764.

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40

CAMILLO, M. A. P. "Purificacao do hormonio de crescimento humano. Isolamento da variante 22 K. Ensaios de atividades biologica e radioimunologica." reponame:Repositório Institucional do IPEN, 1985. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11331.

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Made available in DSpace on 2014-10-09T12:50:47Z (GMT). No. of bitstreams: 0<br>Made available in DSpace on 2014-10-09T13:58:20Z (GMT). No. of bitstreams: 1 02293.pdf: 2942133 bytes, checksum: e4983ce1244ec66900b5ab94fd7a126b (MD5)<br>Dissertacao (Mestrado)<br>IPEN/D<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP

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41

Melo, Maria Edna de. "Estudo do gene LHX4 em pacientes com hipopituitarismo associado a neuro-hipófise ectópica." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-10102014-104531/.

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INTRODUÇÃO: O hipopituitarismo está associado, em cerca de 40% dos casos, à ectopia da neuro-hipófise observada em imagem por ressonância magnética (RM). Nestes pacientes a visualização da haste ocorre predominantemente nos que têm deficiência isolada de GH (DIGH), enquanto a não visualização da mesma está mais associada à deficiência hipofisária múltipla (DHM). A etiologia deste quadro, no entanto, permanece indeterminada na maioria dos pacientes. A elevada freqüência de parto pélvico e de complicações neonatais sugere uma causa traumática, enquanto que relatos de casos familiares, associação

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42

Chazot, Paul L. "Molecular characterisation of the Dâ†2-dopamine receptors from bovine brain and pituitary gland." Thesis, University of Kent, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302788.

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43

Cook, Julia Vanessa Foskett. "Site-directed mutagenesis studies of the GnRH and TRH receptors of the pituitary gland." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/27825.

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The aim of this thesis was to study the structure-function relationships of the G-protein coupled GnRH receptor and has focused on the identification of key amino acids involved in GnRH receptor-ligand interactions as well as the role of putative disulphide bridge formation within the receptor itself. In addition, the role of disulphide bridges has also been explored in another G-protein coupled receptor (GPCR), the thyrotrophin-releasing hormone (TRH) receptor. Based on primary amino acid sequence data and computer-assisted molecular models, potentially important amino acids were targeted for

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44

Newey, Paul J. "The role of the tumour suppressor proteins, parafibromin and menin, in endocrine tumourigenesis." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711613.

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45

朱美詩 and Mei-sze Chu. "Biphasic growth hormone release induced by protein kinase C activationin grass carp pituitary cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B3122250X.

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46

Cheung, L. "Genetic manipulation of the Wnt and Notch signalling pathways in the pituitary gland in vivo." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1408913/.

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The Wnt and Notch signal transduction pathways are two important regulators of pituitary organogenesis. Wnt signalling regulates maintenance, proliferation and differentiation of the progenitor pool during early pituitary development, whilst Notch signalling prevents the premature specification of endocrine cell-types. Components of the Wnt and Notch pathways are downregulated in the pituitary as development proceeds. Furthermore, their expression is detected in the mature, adult gland. Our studies investigate the role of Wnt and Notch signalling in the adult and developing pituitary gland thr

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47

Chu, Mei-sze. "Biphasic growth hormone release induced by protein kinase C activation in grass carp pituitary cells /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21451564.

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48

Wormald, Patricia J. "GnRH and neuropeptide regulation of gonadotropin secretion from cultured human pituitary cells." Doctoral thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/27168.

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Gonadotropin-releasing hormone (GnRH) and its superactive analogues are currently being used in the treatment of a number of endocrine disorders, such as endometriosis, precocious puberty, infertility and prostatic cancer. Selection of these analogues for clinical use have been previously based on their activities in animal models. This thesis has therefore investigated the binding characteristics of the human GnRH receptor, in comparison to those of the rat receptor, as well as the activities of a number of GnRH analogues for stimulating luteinising hormone (LH) and follicle stimulating hormo

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49

Yarney, Thaddeus A. "Sexual maturational changes in the pituitary and testes of ram lambs and predictability of adult reproductive function." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72049.

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Spring-born ram lambs were used to examine: (1) sexual maturational changes in LH, FSH and prolactin (PRL) secretion, testicular gonadotropin receptors, and testicular size and function; (2) predictability of yearling ram reproductive function from juvenile testicular size and reproductive hormone measurements. Despite continuous increases in testis size, serum LH-profile characteristics became greatest between 2 and 4 months and declined thereafter. However, LH-peak frequency increased by about 2-fold between 6 and 7 months; this was associated with marked increases in testosterone (T) secret

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50

Lessey, Andrew James. "The role of C-type natriuretic peptides (CNP) on pituitary development and body growth in zebrafish : molecular investigations of neuroendocrine development." Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701675.

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