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Journal articles on the topic 'Pituitary Micro Adenoma'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Rambharat, Bairwa, and S. Rai G. "A Case of Atypical Pituitary Macro Adenoma." PJSR 14, no. 1 (2020): 1–7. https://doi.org/10.5281/zenodo.8228278.

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We report a case of 17 years old male with chief complaints of severe right hemi cranial headache since 3 days for  which he seeks advice from local doctor, but did not get relief. Patient also has short height and markedly decreased vision  since last 6 weeks. Patient under gone for MRI brain with contrast revealed a large “figure of 8” markedly enhancing sellar  mass with suprasellar and right para sellar extension s/o atypical pituitary macro adenoma. Markedly raised Serum prolactin  (470ng/ml) and mildly reduced FSH & LH were noted.

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2

Takano, Shingo, Hiroyoshi Akutsu, Takuma Hara, Tetsuya Yamamoto, and Akira Matsumura. "Correlations of Vascular Architecture and Angiogenesis with Pituitary Adenoma Histotype." International Journal of Endocrinology 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/989574.

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Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in solid tumors. However, its role in angiogenesis in pituitary adenoma is controversial. Angiogenesis in solid tumors including pituitary adenoma is commonly evaluated by microvascular density (MVD). Here, we evaluated MVD and the role of VEGF in vascular architecture in 51 pituitary adenomas (24 nonfunctioning, 13 prolactin-secreting, 10 growth hormone-secreting, 3 adrenocorticotropic hormone-secreting, and 1 thyroid-stimulating hormone-secreting). Paraffin sections were stained with CD34 and VEGF. MVD and vascular archi

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3

Shyukyurov, S. D., and V. A. Mirzazade. "DETERMINATION OF THE ODDS RATIO FOR DETECTION OF MICRO- AND MACROPROLACTINOMA DEPENDING ON THE LEVEL OF HYPERPROLACTINAEMIA." "The Medicine and Science" scientific-practical journal named after A.Aliyev 2, no. 36 (2024): 89–93. https://doi.org/10.61775/2413-3302.v2i36.13.

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This study examines the determination of the odds ratio of detecting micro- and macroprolactinomas according to the level of hyperprolactinaemia. Purpose. To determine the odds ratio for detection of microprolactinoma and macroprolactinoma depending on the level of hyperprolactinaemia. Material and methods. 139 patients were included in the study and divided into 2 groups: group 1-hyperprolactinaemia without pituitary adenoma (n=26) and group 2-hyperprolactinaemia with pituitary adenoma (n=113). Of 113 patients in group 2, 60 had microadenoma and 53 had macroadenoma. Results. The results show

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Nair, Aiswarya K., Haritha Sagili, Jayalakshmi Dorairaj, and T. Parvathi. "Acromegaly incidentally diagnosed at term in a pregnant woman presenting with ventricular premature complexes." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 7 (2021): 2907. http://dx.doi.org/10.18203/2320-1770.ijrcog20212693.

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Pituitary adenomas lead to increased growth hormone production and acromegaly. Pregnancy in acromegaly is rare as spontaneous conception is affected. We presented a case of 31 year old lady conceived by ovulation induction and presented at term gestation with ventricular premature complexes and was subsequently diagnosed with pituitary micro adenoma causing acromegaly. There has been no reported case of pregnancy with acromegaly presenting with premature ventricular complexes. Moreover, diagnosis of acromegaly in pregnancy is difficult and limited literature is available on its effects as well

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5

International, Journal of Medical Science and Innovative Research (IJMSIR). "Multiple Endocrine Neoplasia Type 1: A Case Report." International Journal of Medical Science and Innovative Research (IJMSIR) 9, no. 6 (2024): 131–38. https://doi.org/10.5281/zenodo.15449118.

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<strong>Abstract</strong> <strong>Background: </strong>Multiple endocrine neoplasia type 1 (MEN1) is a rare genetic syndrome inherited in an autosomal dominant pattern, resulting from mutations in the MEN1 tumor suppressor gene. Diagnosis is typically established based on clinical criteria, characterized by the presence of two or more primary MEN1-associated tumors (including parathyroid, anterior pituitary, and pancreatic islet tumors). Here, we present the case of a patient who exhibited classic clinical features and imaging findings consistent with MEN1. <strong>Case Report: </strong>A man

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Rajani, Mehak, Yumna Mirza, Rohan Advani, Syed Muhammad Adnan Ali, and Syed Ather Enam. "Role of microRNAs in non-functioning pituitary adenoma." Journal of the Pakistan Medical Association 72, no. 01 (2022): 126. http://dx.doi.org/10.47391/jpma.3149.

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Non-functioning pituitary adenomas account for 30% of anterior pituitary tumours. Based on their inability to secrete hormones, these are often diagnosed incidentally or due to pressure symptoms. Understanding the pathogenesis of these adenomas can provide insight into factors leading to its progression and serving as biomarkers for early recognition. A literature search was performed in the current narrative review for articles published in PubMed for the last 10 years till January 2020 on micro-ribonucleic acid involved in the pathogenesis of non-functioning pituitary adenomas. Of the 478 ar

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7

Krzentowska, Anna, and Maria Smoter. "Clinical and Radiological Characteristics of a Patient with a Pituitary Tumor of the Prolactinoma Type — Case Report." Journal of Neurological and Neurosurgical Nursing 13, no. 2 (2024): 78–84. http://dx.doi.org/10.15225/pnn.2024.13.2.5.

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Introduction. Prolactinoma is a benign tumor of the anterior lobe of the pituitary gland. It is the most common type of pituitary adenoma. In terms of size, micro- and macroprolactinomas are distinguished. Prolactinoma is mostly a benign tumor (>98%). Symptoms in hyperprolactinemia are the result of excess hormone and mass effect. Symptoms of the mass effect include headaches, visual disturbances and dizziness. Excess prolactin leads to infertility and “amenorrhea — galactorrhea” syndrome. Aim. To increase general understanding and awareness of the symptoms, causes, and treatments of patien

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8

Suyambulingam, Anbalagan. "A Headache - Free Journey: Managing Pituitary Micro - Adenoma in a Young Unmarried Woman." International Journal of Science and Research (IJSR) 13, no. 5 (2024): 1459. http://dx.doi.org/10.21275/sr24523165233.

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9

Aryal, Saroj Babu, Shasank Chitrakar, and Akriti Panthi. "Conjunction of ovarian dermoid cyst in a patient with Pituitary Micro Adenoma: A Case Report." Journal of Nepal Medical Association 63, no. 287 (2025): 533–36. https://doi.org/10.31729/jnma.9122.

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Pituitary adenomas are common intracranial tumors, and ovarian dermoids are frequently encountered benign gynecological lesions. While both conditions are individually prevalent, their co-existence is rare and infrequently reported. This unusual combination may pose diagnostic challenges and warrants further exploration to determine any potential underlying link. We present a case of a 42-year-old Hindu female who was diagnosed case of a pituitary adenoma with a leftsided ovarian dermoid cyst resulting in a gynecological and hormonal imbalance. The diagnosis was confirmed by subsequent related

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Gedvilaite-Vaicechauskiene, Greta, Loresa Kriauciuniene, Arimantas Tamasauskas, et al. "Pituitary Adenoma: SSTR2 rs2236750, SSTR5 rs34037914, and AIP rs267606574 Genetic Variants, Serum Levels, and Ki-67 Labeling Index Associations." Medicina 60, no. 8 (2024): 1252. http://dx.doi.org/10.3390/medicina60081252.

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Background and Objectives: This study explores the complex pathogenesis of pituitary adenomas (PAs), prevalent intracranial tumors in the pituitary gland. Despite their generally benign nature, PAs exhibit a diverse clinical spectrum involving hormone hypersecretion and varying invasiveness, hinting at multifaceted molecular mechanisms and abnormalities in tumorigenesis and gene regulation. Materials and Methods: The investigation focuses on the Ki-67 labeling index, SSTR2 rs2236750, SSTR5 rs34037914, and AIP rs267606574 polymorphisms, alongside serum levels of SSTR2, SSTR5, and AIP, to discer

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Fozia, Raza, Rai GS, and Saraf Abhinesh. "Role of MRI in Assessment of Pituitary Lesions: A Case Series of Pituitary Masses." PJSR 14, no. 1 (2021): 1–7. https://doi.org/10.5281/zenodo.8216698.

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Pituitary masses are relatively common among general population with incidence varying from 10-12 percent. Most of these lesions are small, even microscopic; consequently, most patients are asymptomatic. Unnecessary surgery should be avoided by improving understanding of disease and its natural history. To diagnose intracranial pathology, we have conducted an observational case series of patients referred to the Department of Radiodiagnosis PCMS and RC for MRI brain. Patients with pituitary masses were identified with pituitary enlargement nearby or approaching the sellar region on MR imaging.

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12

Abdel Raheem, A. "P-03-001 Sexual dysfunction secondary to a pituitary micro-adenoma." Journal of Sexual Medicine 13, no. 5 (2016): S172. http://dx.doi.org/10.1016/j.jsxm.2016.03.222.

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13

Regmi, Deepak, Amit Thapa, Bidur KC, and Bikram Shakya. "Endoscopic Endonasal Transsphenoidal Approach to Pituitary Adenoma: A Multi-disciplinary Approach." Journal of Nepal Health Research Council 15, no. 2 (2017): 174–77. http://dx.doi.org/10.3126/jnhrc.v15i2.18209.

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Background: The excellent visualization and minimally invasive approach employed in endoscopic endonasal procedures has now revolutionized the pituitary surgery, replacing the transnasal microscopic technique worldwide. However, it involves major shift in hand-eye co-ordination from static 3 dimensional images of microscope to 2 dimensional endoscopic images hence demands training and inter-disciplinary approach. Here we present our experiences in learning and developing a safe endonasal transsphenoidal endoscopic approach to resect pituitary adenomas.Methods: This prospective study was jointl

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Sugiyama, Natsuki, Satoshi Tsutsumi, Akane Hashizume, Keisuke Murofushi, Hideaki Ueno, and Hisato Ishii. "Unexpected internal carotid artery injury during endoscopic transsphenoidal surgery." Surgical Neurology International 16 (February 28, 2025): 74. https://doi.org/10.25259/sni_912_2024.

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Background Internal carotid artery (ICA) injury is a rare but severe complication of transsphenoidal surgery. Case Description A 69-year-old woman presented with progressive visual disturbance secondary to pituitary adenoma. The patient underwent subtotal tumor resection through endoscopic transsphenoidal surgery. The residual tumor in the cavernous sinus gradually enlarged over the next 3 years. During a second surgical intervention, an inadvertent scratch, with the worn-out tip of the micro-suction device, on the partially calcified medial wall of the C4 segment resulted in ICA rupture, lead

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Andrusca, Alexandru, Olga Gavriliuc, Pavel Gavriliuc, Paula Fala, Daniel Prisneac, and Victor Andronachi. "Functional pituitary adenoma associated with uninterrupted middle cerebral artery eruption. Case Study." Bulletin of the Academy of Sciences of Moldova. Medical Sciences 71, no. 3 (2022): 250–53. http://dx.doi.org/10.52692/1857-0011.2021.3-71.48.

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The association between cerebral sacral aneurysm and pituitary adenoma has not yet been well elucidated, with some authors reporting an incidence of up to 7.4%. The cause is not yet fully known. 97% of these aneurysms belong to the anterior cerebral circulation. Description of a case study in which a functional selective expansive process and uninterrupted intracerebral aneurysm of the middle cerebral artery are determined. The 57-year-old patient is diagnosed with pituitary adenoma with cavernous sinus invasion and Cushing’s syndrome. On investigation by MRI and AngioCT, an associated aneurys

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Mohammed, Rana Kareem, Abdullah Arnoos Abdulhasan, and Shatha Mohammed Fezea. "Response to Treatment in a sample of Iraqi Patients with Prolactinoma." Medical Journal of Babylon 22, no. 2 (2025): 514–18. https://doi.org/10.4103/mjbl.mjbl_1722_23.

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Abstract Background: Hyperprolactinemia is a common endocrine abnormality caused by physiological factors like pregnancy and lactation, drug-induced factors like antipsychotics, pituitary adenomas that secrete prolactin, or stalk compression or section that reduces dopamine inhibition. Dopamine agonists cure most prolactinomas. Objectives: To assess response to treatment in micro versus macroprolactinoma. Materials and Methods: A total of 35 patients (20 female and 15 male) with documented hyperprolactinemia (serum prolactin above the assay-specific reference range) due to prolactin-secreting

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Wong, Zhe Lan, Eileen Tan, Ilham Ismail, Nurbadriah Jasmiad, Chee Keong See, and Saiful Shahrizal Shudim. "APOPLEXY IN MICROPROLACTINOMA." Journal of the ASEAN Federation of Endocrine Societies 38, S2 (2023): 51. https://doi.org/10.15605/jafes.038.s2.79.

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INTRODUCTION/BACKGROUNDPituitary adenoma apoplexy is uncommon and often occurs spontaneously as a result of infarction, haemorrhage or a combination of both. Pituitary apoplexy is potentially life threatening and has long term consequences resulting in permanent hormonal deficiencies. It is often associated with pituitary macroadenoma and occurrence with pituitary microadenoma is rare. CASEWe report a case of micro-prolactinoma with pituitary apoplexy on follow-up pituitary MRI. A 29-year-old female who presented with secondary oligomenorrhea in December 2021 was subsequently diagnosed with mi

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18

Crock, Patricia A., Dieter K. Lüdecke, Ulrich J. Knappe, and Wolfgang Saeger. "A personal series of 100 children operated for Cushing’s disease (CD): optimizing minimally invasive diagnosis and transnasal surgery to achieve nearly 100% remission including reoperations." Journal of Pediatric Endocrinology and Metabolism 31, no. 9 (2018): 1023–31. http://dx.doi.org/10.1515/jpem-2018-0262.

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AbstractBackgroundTransnasal surgery (TNS) is the first choice in the treatment of pediatric Cushing’s disease. The question is how can high remission rates be achieved with minimally invasive investigations and TNS whilst avoiding radiotherapy or bilateral adrenalectomy in children.MethodsData from a published series 1 (n=55) of surgeon DKL will be compared with his recent series 2 (n=45) until 2009. All patients were operated by direct transnasal microsurgery. Over time, inferior petrosal sinus sampling (IPSS) was replaced by cavernous sinus sampling (CSS), restricted to unclear cases withou

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Abaturov, A. E., A. O. Nikulina, and T. D. Alieinykova. "Clinical features of hyperprolactinemia in children: modern methods of diagnosis and treatment." CHILD`S HEALTH 17, no. 1 (2022): 28–36. http://dx.doi.org/10.22141/2224-0551.17.1.2022.1489.

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Hyperprolactinemia is a common endocrine disease that can be associated with significant morbidity and disability in the population. A systematic review of literature sources on the diagnosis and treatment results in patients with hyperprolactinemia, including drug-resistant micro- and macroadenomas of the pituitary gland, was carried out in order to highlight the most significant practical recommendations. The purpose of this literature review is to provide algorithms for differential diagnosis and clinical observation of patients, to compare the efficacy and side effects of drugs, surgeries,

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Fatemi, Nasrin, Joshua R. Dusick, Manoel A. de Paiva Neto, and Daniel F. Kelly. "The Endonasal Microscopic Approach for Pituitary Adenomas and Other Parasellar Tumors: A 10-year Experience." Operative Neurosurgery 63, suppl_4 (2008): ONS244—ONS256. http://dx.doi.org/10.1227/01.neu.0000327025.03975.ba.

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Abstract THE DIRECT ENDONASAL transsphenoidal approach to the sella with the operating microscope was initially described more than 20 years ago. Herein, we describe the technique, its evolution, and lessons learned over a 10-year period for treating pituitary adenomas and other parasellar pathology. From July 1998 to January 2008, 812 patients underwent a total of 881 operations for a pituitary adenoma (n = 605), Rathke’s cleft cyst (n = 59), craniopharyngioma (n = 26), parasellar meningioma (n = 23), chordoma (n = 18), or other pathological condition (n = 81). Of these, 118 operations (13%)

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Srivastava, Alok, Manish Singh, Awadhesh Yadav, Chhitij Srivastava, Akanksha D. Srivastava, and Sugandha Jauhari. "CLINICAL PICTURE AND CURRENT MANAGEMENT OF PITUITARY TUMORS: A REVIEW." International Journal of Advanced Research 11, no. 09 (2023): 1298–303. http://dx.doi.org/10.21474/ijar01/17648.

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The pituitary is a pea-sized complex gland located below the hypothalamus at the base of skull in the sella turcica, is composed of three types of cells. Pituitary being the centre of all the stimulating hormones of various organs, its overgrowth leads to hormone excess syndromes, like acromegaly, Cushing disease, central hypothyroidism, and hyperprolactinemia etc. so studies involving pituitary tumors have mainly focused on hormone production. Pituitary Adenoma is the most common (~85%) tumor in the sellar-suprasellar region. Their prevalence is growing which has risen over the last 20 years

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Tresoldi, Alberto Stefano, Giulia Carosi, Nazarena Betella, et al. "Clinically Nonfunctioning Pituitary Incidentalomas: Characteristics and Natural History." Neuroendocrinology 110, no. 7-8 (2019): 595–603. http://dx.doi.org/10.1159/000503256.

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Introduction: Available data on pituitary incidentalomas mostly derive from small-scale studies, with heterogeneous inclusion criteria and limited follow-up. No paper has focused specifically on clinically nonfunctioning pituitary incidentalomas (CNFPIs). Objective: To describe the characteristics and the natural history of patients diagnosed with CNFPIs. Methods: Retrospective multicenter cohort study evaluating hormonal, imaging, and visual field characteristics at diagnosis and during follow-up of CNFPIs investigated in 2 Pituitary Centers. Results: Three hundred and seventy-one patients

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Fountas, Athanasios, Eugenie S. Lim, William M. Drake, et al. "Outcomes of Patients with Nelson’s Syndrome after Primary Treatment: A Multicenter Study from 13 UK Pituitary Centers." Journal of Clinical Endocrinology & Metabolism 105, no. 5 (2019): 1527–37. http://dx.doi.org/10.1210/clinem/dgz200.

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Abstract Context Long-term outcomes of patients with Nelson’s syndrome (NS) have been poorly explored, especially in the modern era. Objective To elucidate tumor control rates, effectiveness of various treatments, and markers of prognostic relevance in patients with NS. Patients, design, and setting Retrospective cohort study of 68 patients from 13 UK pituitary centers with median imaging follow-up of 13 years (range 1–45) since NS diagnosis. Results Management of Cushing’s disease (CD) prior to NS diagnosis included surgery+adrenalectomy (n = 30; eight patients had 2 and one had 3 pituitary o

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Sarfraz, Sehar, Tayyaba Ali, Pakeeza Shafiq, et al. "Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard." Pakistan Journal of Medicine and Dentistry 14, no. 1 (2025): 74–80. https://doi.org/10.36283/ziun-pjmd14-1/012.

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Background: Pituitary microadenomas (PMs) are common benign tumors that are often not visualized even when they are present due to their asymptomatic nature. The objective of the study was to evaluate the diagnostic accuracy of non-contrast magnetic resonance imaging (MRI) in the diagnosis of pituitary microadenomas using histopathology as a gold standard. Methods: This cross-sectional validation study (IRB Approval No. IRB/18/2024/01) included 121 patients presenting with severe headaches and focal brain lesions on CT scans at Doctors Hospital, Lahore from September 2024 to November 2024. In

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Šulavíková, Zuzana, and Vladimír Krásnik. "Giant Prolactinoma. A Case Report." Czech and Slovak Ophthalmology 79, no. 3 (2023): 143–48. http://dx.doi.org/10.31348/2023/20.

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Aim: Prolactinoma is a pituitary adenoma that secretes prolactin. Approximately 40% of all pituitary adenomas are prolactinomas. According to size, they are divided into micro, macro and giant prolactinomas. In women, prolactinomas cause irregularities of the menstrual cycle such as amenorrhea, galactorrhea, weight gain, in both sexes they cause sterility, hypogonadism, decreased libido and depression. In macroadenomas, symptoms due to the compression of the surrounding structures are also manifested, such as headache, vomiting, lower chiasmatic syndrome and ophthalmoplegia. Loss of the visual

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Chamsi, F. Z., H. Aberbak, S. Radi, and A. El Ammouri. "Management of comorbid schizophrenia with prolactinome (about a case)." European Psychiatry 66, S1 (2023): S1056. http://dx.doi.org/10.1192/j.eurpsy.2023.2240.

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IntroductionProlactin adenoma, called “prolactinoma” is a benign neoplasm, it is the most common secreting pituitary tumor, and represents up to 40% of all pituitary adenomas. More than 90% are small intrasellar tumors which rarely increase in size.Objectivesthe problem of management lies in how to stabilize the patient on a psychiatric level without increasing the level of prolactin.MethodsWe report the case of a young woman who presented a comorbid schizophrenia with a prolactinoma. We will try through this clinical vignette to study the different pillars of management of such pathologies.At

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Costachescu, Mihai, Claudiu Nistor, Ana Valea, et al. "A Real-World Longitudinal Study in Non-Functioning Pituitary Incidentalomas: A PRECES Micro-Adenomas Sub-Analysis." Diseases 12, no. 10 (2024): 240. http://dx.doi.org/10.3390/diseases12100240.

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Background. Incidentalomas have an increasing incidence all over the world due to a larger access to imaging assessments, and endocrine incidentalomas make no exception in this matter, including pituitary incidentalomas (PIs). Objective. Our objective was to analyse the dynamic changes amid a second computed tomography (CT) scan after adult patients were initially confirmed with a PI (non-functioning micro-adenoma). Methods. This was a multi-centric, longitudinal, retrospective study in adults (aged between 20 and 70 y) amid real-world data collection. We excluded patients who experienced base

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Al-Ansari, Rehab Yusuf, Maha Jurais Al Otaibi, Amal Mohsen Al-Ghamdi, Nada Rajab Al-Zahrani, and Alexander Woodman. "Coexistence of Essential Thrombocythemia and Pituitary Adenoma: A Case Report of a Saudi Female Patient." Journal of Applied Hematology 15, no. 2 (2024): 156–59. http://dx.doi.org/10.4103/joah.joah_112_23.

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Abstract: Essential thrombocythemia (ET) is a malignant hematological disease that has the ability to progress to acute leukemia or transform into other myeloproliferative neoplasms (MPNs). The coexistence of ET and other MPNs with pituitary adenoma (PA) is rare. There are no reports of cases of secretory PA of prolactin hormone in combination with ET. This case was reported in a young woman from Saudi Arabia who had the secretory PA present in combination with ET. The 20-year-old patient was treated for a micro-PA with hyperprolactinemia. The patient was referred to the hematological service

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Alfì, Gaspare, Danilo Menicucci, Dalì Antonia Ciampa, et al. "How Different Treatments for Acromegaly Modulate Sleep Quality: A Psychometric Study." Endocrines 5, no. 3 (2024): 408–17. http://dx.doi.org/10.3390/endocrines5030030.

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Acromegaly is a rare endocrine syndrome characterized by unrestrained growth hormone (GH) secretion from a GH-secreting pituitary neuroendocrine tumor (PitNET). Data on sleep disorders are scanty and mainly linked to Obstructive Sleep Apnea Syndrome (OSAS). This study aimed to evaluate the prevalence of insomnia and sleep quality in a cohort of patients with a low risk of OSAS before and after therapies for acromegaly. A total of 27 naïve acromegalic patients (mean age 55.15 ± 10.53 years) were submitted to a psychometric sleep evaluation and compared to a matched control group of 24 Non-Funct

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Barabash, Nadiya, and Tetiana M. Tykhonova. "Experience with Dopamine Agonists in the Treatment of Prolactinomas." Acta medica Lituanica 29, no. 2 (2022): 15. http://dx.doi.org/10.15388/amed.2022.29.2.15.

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The article is devoted to the conservative treatment of hyperprolactinemia of tumor origin. Cabergoline is considered as an effective treatment not only for microadenomas but also for large pituitary tumors which is illustrated by the clinical case of the patient P. The most important effects of cabergoline demonstrated in this clinical case are reduction in the size of the adenoma from macro to micro, reverse development of chiasmal syndrome with restoration of visual functions, achievement and maintenance of the target level of prolactin. Besides the article focused on the possible developme

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Yamada, Shozo, Noriaki Fukuhara, Kenichi Oyama, Akira Takeshita, and Yasuharu Takeuchi. "Repeat Transsphenoidal Surgery for the Treatment of Remaining or Recurring Pituitary Tumors in Acromegaly." Neurosurgery 67, no. 4 (2010): 949–56. http://dx.doi.org/10.1227/neu.0b013e3181ec4379.

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Abstract BACKGROUND: Acromegaly is a disorder characterized by hypersecretion of growth hormone caused by a growth hormone–secreting pituitary adenoma. OBJECTIVE: To evaluate the long-term efficacy and safety of repeat transsphenoidal surgery for persistent or recurrent acromegaly. METHODS: We retrospectively reviewed records for 53 acromegalic patients who underwent repeat transsphenoidal surgery for persistent or progressive acromegaly at Toranomon Hospital between 1987 and 2006. Multivariate logistic regression was performed to evaluate preoperative factors influencing the surgical outcome.

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Duseikaite, Monika, Alvita Vilkeviciute, Igne Dumbliauskaite, et al. "The Value of Optical Coherence Tomography in Patients with Pituitary Adenoma and Its Association with Clinical Features: A Pilot Study." Journal of Clinical Medicine 14, no. 12 (2025): 4318. https://doi.org/10.3390/jcm14124318.

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Background: The main mechanism of optic nerve damage in patients with pituitary adenoma (PA) is the pressure of optic chiasm. The retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL)+, and GCL++ thickness measurement by optical coherence tomography (OCT), visual function evaluation, and magnetic resonance imaging (MRI) can be used to predict visual function recovery. In our study, we investigated the associations between visual acuity (VA), visual field (VF), RNFL, GCL changes, and the findings of MRI in patients with PA. Methods: This study was conducted in the Departments of Ophth

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Fux Otta, Carolina, Laura Cecenarro, María Eugenia Estario, and Paula Estario. "Prolactinoma y embarazo." Revista de la Facultad de Ciencias Médicas de Córdoba 72, no. 3 (2015): 170–74. http://dx.doi.org/10.31053/1853.0605.v72.n3.12055.

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RESUMEN Los prolactinomas son los tumores hipofisarios funcionantes más comunes. La hiperprolactinemia que generan se asocia con anovulación e infertilidad. OBJETIVOS: a) describir la relación entre hiperprolactinemia y fertilidad, b) revisar los resultados del uso de agonistas dopaminérgicos durante el embarazo y el desarrollo embriofetal y c) actualizar el manejo terapéutico en micro y macroprolactinomas durante la gestación. CONTENIDO: Los agonistas dopaminérgicos son el tratamiento de primera línea para prolactinomas de cualquier tamaño o grado de invasión y restauran los ciclos ovulatorio

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Ingley, Megan, Patrick Quebedeaux, Kristen Schmidbauer, Idris Ali Amghaiab, and Jacqueline Chan. "PMON315 Hyperglycemia Dilemma: Concomitant Type 1 Diabetes Mellitus and Cushing's disease." Journal of the Endocrine Society 6, Supplement_1 (2022): A624—A625. http://dx.doi.org/10.1210/jendso/bvac150.1295.

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Abstract Introduction Type 1 diabetes (T1DM) is an autoimmune condition causing destruction of insulin-producing pancreatic beta cells. About a third of patients present with DKA at diagnosis. Insulin is mainstay therapy to achieve glucose control. Glucose hemostasis is affected by several factors. Conditions including acute illness or endocrinopathy such as Cushing's disease can cause hyperglycemia. We present a case of a pediatric patient with T1DM and difficult to control hyperglycemia due to concomitant hypercortisolism. Case The patient is an eleven-year-old male, who first presented in D

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Akirov, Amit, Ilan Shimon, Maria Fleseriu, et al. "Clinical Study and Systematic Review of Pituitary Microadenomas vs. Macroadenomas in Cushing’s Disease: Does Size Matter?" Journal of Clinical Medicine 11, no. 6 (2022): 1558. http://dx.doi.org/10.3390/jcm11061558.

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Background: Reports on clinical and biochemical differences between adrenocorticotropic hormone (ACTH)-secreting pituitary microadenomas and macroadenomas are limited and inconsistent. Objective: Compare clinical and biochemical characteristics of patients with corticotroph microadenomas and macroadenomas and assess predictive factors for biochemical response to dynamic testing for Cushing’s disease (CD) in a clinical trial and a systematic review. A second aim was to evaluate differences between macroadenomas with and without cavernous and sphenoid sinus invasion. Methods: Retrospective chart

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Abhayaratna, Sachith. "Abstract #806932: Rare Case of Cushing’s Syndrome and Primary Aldosteronism with Imaging Findings of Bilateral Adrenal Masses With Coexisting Pituitary Micro Adenoma Presenting with Severe Hypokalaemia and Unusual Electromyography Findings." Endocrine Practice 26 (May 2020): 29–30. http://dx.doi.org/10.1016/s1530-891x(20)39754-8.

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Yang, Shu-Yuan, Tao Zhu, Jian-Ning Zhang, and Yin-Shui Sun. "Transsphenoidal microsurgical management of pituitary adenomas." Microsurgery 15, no. 11 (1994): 754–59. http://dx.doi.org/10.1002/micr.1920151103.

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Pierantoni, Giovanna Maria, Palma Finelli, Emanuele Valtorta, et al. "High-mobility group A2 gene expression is frequently induced in non-functioning pituitary adenomas (NFPAs), even in the absence of chromosome 12 polysomy." Endocrine-Related Cancer 12, no. 4 (2005): 867–74. http://dx.doi.org/10.1677/erc.1.01049.

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The high-mobility group A2 (HMGA2) gene has a critical role in benign tumors where it is frequently rearranged, and in malignant tumors, where it is overexpressed in the absence of structural modification of the HMGA2 locus. By previous fluorescence in situ hybridization (FISH) and reverse transcriptase PCR analyses on human prolactin-secreting pituitary adenomas we detected rearrangement of the HMGA2 gene and amplification of its native region associated with activated expression. These data indicated a role for the HMGA2 gene in the development of human pituitary prolactinomas, since they ar

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Skoric, T., M. Korsic, K. Zarkovic, et al. "Clinical and morphological features of undifferentiated monomorphous GH/TSH-secreting pituitary adenoma." European Journal of Endocrinology 140, no. 6 (1999): 528–37. http://dx.doi.org/10.1530/eje.0.1400528.

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A 41-year-old male presented with progressive visual defects, acromegaly and hyperthyroidism. After clinical evaluation a giant GH/TSH-secreting pituitary adenoma was diagnosed. Administration of the somatostatin analog octreotide at doses of 150 microg s.c. per day inhibited the secretion of both GH and TSH. A three-week treatment with octreotide prior to surgery led to slight visual improvement and CT scan showed some new necrotic areas within the tumor mass. Transcranial surgery was performed. By immunohistochemical analyses of the adenoma tissue GH, prolactin and beta-chorionic gonadotropi

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Doo Kim, Moon, Beomwoo Nam, Se-Hoon Shim, et al. "S216. CASE REPORT OF TREATMENT OF NEUROLEPTIC MALIGNANT SYNDROME IN CHILD ADOLESCENT." Schizophrenia Bulletin 46, Supplement_1 (2020): S120—S121. http://dx.doi.org/10.1093/schbul/sbaa031.282.

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Abstract Background Neuroleptic Malignant Syndrome is a rare clinical syndrome occurring due to idiosyncratic reaction after use of neuroleptics. We report a case of neuroleptic malignant syndrome in an adolescent patient with schizophrenia after treatment with antipsychotics. Methods Case report. Results A 15-year-old male Schizophrenic patient was admitted to the psychiatric closed ward due to worsening of psychotic symptoms on July of 2017. Pineal cystoma and pituitary microadenoma were detected incidentally on MRI, and consultation with the department of pediatrics recommended close observ

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Tang, Ying, Yue Wu, Hua Zhang, Jing Wang, and ZhenWei Yao. "Increased diagnostic confidence in the diagnosis of pituitary micro-lesions with the addition of three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions sequences." Acta Radiologica 60, no. 2 (2018): 213–20. http://dx.doi.org/10.1177/0284185118774954.

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Background Conventional magnetic resonance imaging (MRI) is adversely affected by thick slices, small intersection gaps, and the partial volume effect, leading to the missed diagnosis or misdiagnosis of pituitary micro-lesions. Purpose To evaluate the diagnostic yield of three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-T2 SPACE) sequences compared with a standard MRI protocol for the diagnosis of pituitary micro-lesions. Material and Methods The MRI findings of 664 patients with clinically suspected pituitary lesions were retr

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González Molero, Inmaculada, Laura Gonzalez, Juan Garcia Arnes, et al. "Serum cortisol in the early post operative period after transphenoidal surgery to predict adrenal insufficiency." Problems of Endocrinology 62, no. 5 (2016): 66–67. http://dx.doi.org/10.14341/probl201662566-67.

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Background. Adrenal insufficiency is a common complication of transsphenoidal surgery (TSS) for pituitary adenoma. It is very important to identify patients requiring glucocorticoid replacement, minimising risks of adrenal insufficiency.Aim: to assess the performance of early ( 3ºday) post-TSS 08:00 a.m. cortisol measurement to detect and exclude secondary adrenal insufficiency.Methods. We selected patients undergoing TSS in our hospital during 12 months and performed a 3º day postoperative 08:00 a.m. cortisol measurement and cortisol+/-Synachten 6 months post-surgery. All patients received pe

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Bae AHN, Moon, and Min Jeong JANG. "ODP393 Pfeiffer syndrome with growth hormone deficiency in a 4-year-old girl." Journal of the Endocrine Society 6, Supplement_1 (2022): A606. http://dx.doi.org/10.1210/jendso/bvac150.1257.

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Abstract Backgrounds Craniosynostosis syndrome has a variety of causes, one of which is an autosomal dominant disorder associated with FGFR1 or FGFR2 gene mutation known as Pfeiffer syndrome (PS; OMIM 101600). It is known that PS is clinically diagnosed, not genetic judgment. PS is divided into three subtypes depending on severity of specific phenotypes. Patients with PS type 1 are broad thumbs and great toes, brachydactyly or syndactyly. They have widely spaced eyes, midface hypoplasia and dental abnormalities but short stature is not typical phenotype of PS. We report the patient who were cl

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Gondim, Jackson A., João Paulo Almeida, Lucas Alverne F. de Albuquerque, Erika Gomes, Michele Schops, and Tania Ferraz. "Pure endoscopic transsphenoidal surgery for treatment of acromegaly: results of 67 cases treated in a pituitary center." Neurosurgical Focus 29, no. 4 (2010): E7. http://dx.doi.org/10.3171/2010.7.focus10167.

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Object Acromegaly is a chronic disease related to the excess of growth hormone (GH) and insulin-like growth factor–I secretion, usually by pituitary adenomas. Traditional treatment of acromegaly consists of surgery, drug therapy, and eventually radiotherapy. The introduction of endoscopy as an additional tool for surgical treatment of pituitary adenomas and, therefore, acromegaly represents an important advance of pituitary surgery in the recent years. The aim of this retrospective study is to evaluate the results of pure transsphenoidal endoscopic surgery in a series of patients with acromega

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Berker, Mustafa. "Micro CT analysis of sellar floor in pituitary adenomas, especially in Cushing's disease." Acta Endocrinologica (Bucharest) 6, no. 4 (2010): 481–92. http://dx.doi.org/10.4183/aeb.2010.481.

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Cecenarro, Laura Anahi, E. T. Rodrigo Fanton, Paula Estario, Roque Francisco Papalini, and María Eugenia Estario. "Adenomas hipofisarios: análisis de la casuística de 10 años." Revista de la Facultad de Ciencias Médicas de Córdoba 72, no. 1 (2015): 32–38. http://dx.doi.org/10.31053/1853.0605.v72.n1.11929.

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RESUMENINTRODUCCION: Los tumores hipofisarios comprenden la cuarta parte de las neoplasias intracraneales y los adenomas son el mayor porcentaje de ellos. Son de naturaleza benigna, pero pueden ser invasivos y producir impacto en la morbi-mortalidad. OBJETIVO: analizar las características clínicas de los pacientes con diagnóstico de adenomas hipofisarios y crear un registro computarizado para mejorar las estrategias de diagnóstico y seguimiento de estos pacientes. METODOLOGÍA: Se realizó un análisis retrospectivo, descriptivo, de 102 historias clínicas sobre un total de 191 pacientes que concu

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Khan, AbQueem, ManzoorA Tali, Yasir Bashir, et al. "MODIFIED TECHNIQUE OF TRANS-NASAL TRANS-SPHENOIDAL MICRO-DECOMPRESSION FOR PITUITARY ADENOMAS-AN EXPERIENCE." International Journal of Advanced Research 4, no. 7 (2016): 1940–44. http://dx.doi.org/10.21474/ijar01/1076.

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Ussov, W. Yu, S. M. Minin, Zh Zh Anashbayev, et al. "Quantitative Brain SPECT/CT with 99mTc-Technetril for Visualization and Assessment of the Functional State of Pituitary Adenomas." MEDICAL RADIOLOGY AND RADIATION SAFETY 70, no. 3 (2025): 99–107. https://doi.org/10.33266/1024-6177-2025-70-3-99-107.

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Purpose: We tried to adapt the methodology for quantifying the accumulation of 99mTc-technetril (99mTc-MIBI) in pituitary adenomas, present a pharmacokinetic model for calculating blood flow in the pituitary gland based on the accumulation of 99mTc-technetril and evaluate their relationship with the level of prolactin in the blood in some pathological conditions. Material and methods: The tumor blood flow (TBF) was calculated using the standardized radiopharmaceutical absorption value (SUV) and the minute volume of the heart (MV) as TBF = SUV99mTc-technetril × (MV / BodyWeight) × 100, where 10

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Toffanin, T., F. Nifosì, H. Follador, et al. "Volumetric MRI analysis of hippocampal subregions in Cushing's disease: A model for glucocorticoid neural modulation." European Psychiatry 26, no. 1 (2011): 64–67. http://dx.doi.org/10.1016/j.eurpsy.2010.09.003.

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AbstractSeveral preclinical studies have demonstrated neuronal effects of glucocorticoids on the hippocampus (HC), a limbic structure with anterior–posterior anatomical and functional segmentation. We propose a volumetric magnetic resonance imaging analysis of hippocampus head (HH), body (HB) and tail (HT) using Cushing's disease (CD) as model, to investigate whether there is a differential sensitivity to glucocorticoid neuronal damage in these segments. We found a significant difference in the HH bilaterally after 12 months from trans-sphenoidal surgical selective resection of the adrenocorti

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Raverot, Gérald, Anne Wierinckx, Emmanuel Jouanneau, et al. "Clinical, hormonal and molecular characterization of pituitary ACTH adenomas without (silent corticotroph adenomas) and with Cushing's disease." European Journal of Endocrinology 163, no. 1 (2010): 35–43. http://dx.doi.org/10.1530/eje-10-0076.

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ObjectiveSilent corticotroph adenomas (SCAs) are rare pituitary tumours immunoreactive for ACTH, but without clinical evidence of Cushing's disease. We characterized SCAs based on clinical, hormonal and molecular data, and compared the characteristics of these tumours with those of macro (MCA)- and micro (mCA)-ACTH adenomas with Cushing's disease.MethodsFifty ACTH adenomas (14 SCAs, 15 MCAs and 21 mCAs) with complete corresponding clinical, radiological and biochemical data were selected. Histological corticotroph differentiation; immunostaining for ACTH, β-endorphin and β-LPH; and mRNA expres

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