Relevant bibliographies by topics / PITX2c

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Academic literature on the topic 'PITX2c'

Author: Grafiati
Published: 4 June 2021
Last updated: 6 February 2022

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Journal articles on the topic "PITX2c"

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Yu, X., T. R. St Amand, S. Wang, et al. "Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick." Development 128, no. 6 (2001): 1005–13. http://dx.doi.org/10.1242/dev.128.6.1005.

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Pitx2, a bicoid-related homeobox gene, plays a crucial role in the left-right axis determination and dextral looping of the vertebrate developing heart. We have examined the differential expression and function of two Pitx2 isoforms (Pitx2a and Pitx2c) that differ in the region 5′ to the homeodomain, in early chick embryogenesis. Northern blot and RT-PCR analyses indicated the existence of Pitx2a and Pitx2c but not Pitx2b in the developing chick embryos. In situ hybridization demonstrated a restricted expression of Pitx2c in the left lateral plate mesoderm (LPM), left half of heart tube and he
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Liu, Chengyu, Wei Liu, Mei-Fang Lu, Nigel A. Brown, and James F. Martin. "Regulation of left-right asymmetry by thresholds of Pitx2c activity." Development 128, no. 11 (2001): 2039–48. http://dx.doi.org/10.1242/dev.128.11.2039.

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Although much progress has been made in understanding the molecular mechanisms regulating left-right asymmetry, the final events of asymmetric organ morphogenesis remain poorly understood. The phenotypes of human heterotaxia syndromes, in which organ morphogenesis is uncoupled, have suggested that the early and late events of left-right asymmetry are separable. The Pitx2 homeobox gene plays an important role in the final stages of asymmetry. We have used two new Pitx2 alleles that encode progressively higher levels of Pitx2c in the absence of Pitx2a and Pitx2b, to show that different organs ha
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Essner, J. J., W. W. Branford, J. Zhang, and H. J. Yost. "Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms." Development 127, no. 5 (2000): 1081–93. http://dx.doi.org/10.1242/dev.127.5.1081.

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The pitx2 gene is a member of the bicoid-homeodomain class of transcription factors that has been implicated in the control of left-right asymmetry during organogenesis. Here we demonstrate that in zebrafish there are two pitx2 isoforms, pitx2a and pitx2c, which show distinct expression patterns and have non-overlapping functions during mesendoderm and asymmetric organ development. pitx2c is expressed symmetrically in presumptive mesendoderm during late blastula stages and in the prechordal plate during late gastrulation. pitx2a expression is first detected at bud stage in the anterior prechor
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Lamba, Pankaj, Vishal Khivansara, Ana C. D'Alessio, Michelle M. Santos та Daniel J. Bernard. "Paired-Like Homeodomain Transcription Factors 1 and 2 Regulate Follicle-Stimulating Hormone β-Subunit Transcription through a Conserved cis-Element". Endocrinology 149, № 6 (2008): 3095–108. http://dx.doi.org/10.1210/en.2007-0425.

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Paired-like homeodomain transcription factors (PITX) regulate the activity of pituitary hormone-encoding genes. Here, we examined mechanisms through which the family of PITX proteins control murine FSH β-subunit (Fshb) transcription. We observed that endogenous PITX1 and PITX2 isoforms from murine LβT2 gonadotrope cells could bind a highly conserved proximal cis-element. Transfection of PITX1 or PITX2C in heterologous cells stimulated both murine and human Fshb/FSHB promoter-reporter activities, and in both cases, mutation of the critical cis-element abrogated these effects. In homologous LβT2
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Kitamura, K., H. Miura, S. Miyagawa-Tomita, et al. "Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism." Development 126, no. 24 (1999): 5749–58. http://dx.doi.org/10.1242/dev.126.24.5749.

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Pitx2, a bicoid-related homeobox gene, is involved in Rieger's syndrome and the left-right (L-R) asymmetrical pattern formation in body plan. In order to define the genomic structure and roles of Pitx2, we analyzed the genomic structure and generated Pitx2-deficient mice with the lacZ gene in the homeobox-containing exon of Pitx2. We were able to show that among three isoforms of Pitx2, Pitx2c shows asymmetrical expression whereas Pitx2a, Pitx2b and Pitx2c show symmetrical expression. In Pitx2(−)(/)(−) embryos there was an increase in mesodermal cells in the distal end of the left lateral body
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Toro, Rafael, Irfan Saadi, Adisa Kuburas, Mona Nemer, and Andrew F. Russo. "Cell-specific Activation of the Atrial Natriuretic Factor Promoter by PITX2 and MEF2A." Journal of Biological Chemistry 279, no. 50 (2004): 52087–94. http://dx.doi.org/10.1074/jbc.m404802200.

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The PITX2 homeodomain protein is mutated in patients with Axenfeld-Rieger syndrome and is involved in the development of multiple organ systems, including the heart. We have examined the interaction of PITX2 isoforms with myocyte-enhancing factor 2A (MEF2A), which is a known regulator of cardiac development. A direct interaction between PITX2a and MEF2A was demonstrated using yeast two-hybrid and GST pull-down assays. To study the functional significance of this interaction, we used the atrial natriuretic factor (ANF) promoter. Coexpression of MEF2A and PITX2a or Pitx2c resulted in a strong sy
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Schweickert, Axel, Marina Campione, Herbert Steinbeisser, and Martin Blum. "Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left–right asymmetry." Mechanisms of Development 90, no. 1 (2000): 41–51. http://dx.doi.org/10.1016/s0925-4773(99)00227-0.

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Zhang, Min, Matthew C. Hill, Zachary A. Kadow, et al. "Long-range Pitx2c enhancer–promoter interactions prevent predisposition to atrial fibrillation." Proceedings of the National Academy of Sciences 116, no. 45 (2019): 22692–98. http://dx.doi.org/10.1073/pnas.1907418116.

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Genome-wide association studies found that increased risk for atrial fibrillation (AF), the most common human heart arrhythmia, is associated with noncoding sequence variants located in proximity to PITX2. Cardiomyocyte-specific epigenomic and comparative genomics uncovered 2 AF-associated enhancers neighboring PITX2 with varying conservation in mice. Chromosome conformation capture experiments in mice revealed that the Pitx2c promoter directly contacted the AF-associated enhancer regions. CRISPR/Cas9-mediated deletion of a 20-kb topologically engaged enhancer led to reduced Pitx2c transcripti
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Herraiz-Martínez, Adela, Carmen Tarifa, Estefanía Lozano-Velasco, et al. "Novel PITX2 Homeodomain-Contained Mutations from ATRIAL Fibrillation Patients Deteriorate Calcium Homeostasis." Hearts 2, no. 2 (2021): 251–71. http://dx.doi.org/10.3390/hearts2020020.

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Atrial fibrillation (AF) is the most common cardiac arrhythmia in the human population, with an estimated incidence of 1–2% in young adults but increasing to more than 10% in 80+ years patients. Pituitary Homeobox 2, Paired Like Homeodomain 2 (PITX2c) loss-of-function in mice revealed that this homeodomain (HD)-containing transcription factor plays a pivotal role in atrial electrophysiology and calcium homeostasis and point to PITX2 as a candidate gene for AF. To address this issue, we recruited 31 AF patients for genetic analyses of both the known risk alleles and PITX2c open reading frame (O
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Liu, Chengyu, Wei Liu, Jennifer Palie, Mei Fang Lu, Nigel A. Brown, and James F. Martin. "Pitx2cpatterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions." Development 129, no. 21 (2002): 5081–91. http://dx.doi.org/10.1242/dev.129.21.5081.

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Inactivation of the left-right asymmetry gene Pitx2 has been shown, in mice, to result in right isomerism with associated defects that are similar to that found in humans. We show that the Pitx2c isoform is expressed asymmetrically in a presumptive secondary heart field within the branchial arch and splanchnic mesoderm that contributes to the aortic sac and conotruncal myocardium. Pitx2c was expressed in left aortic sac mesothelium and in left splanchnic and branchial arch mesoderm near the junction of the aortic sac and branchial arch arteries. Mice with an isoform-specific deletion of Pitx2c
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Dissertations / Theses on the topic "PITX2c"

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Di, Giorgio Luciano. "Identification of critical amino acids in the N-terminus of Pitx2c." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82224.

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Pitx2 is a homeodomain transcription factor. Three functional protein isoforms are encoded by the Pitx2 gene that differ only in their N-terminus. Functional studies have demonstrated that the Pitx2c isoform is the most downstream component of the left-right patterning cascade that is responsible for positioning the internal organs relative to the midline.<br>In all vertebrates, mRNA for the Pitx2c isoform is expressed asymmetrically in the left lateral plate mesoderm and in organs that become asymmetrically positioned. A Pitx2c isoform specific antibody was created and used to determin
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Wong, Shian Yea. "Identifying protein interaction partners of the Pitx2c N-terminus during embryogenesis." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123305.

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The vertebrate body is patterned asymmetrically along the left-right axis. Left-right patterning is required to establish correct asymmetric organ formation and positioning, and ultimately it is essential for normal physiological functioning. Misregulation in this process can lead to severe physiological defects in multiple organs, including the heart and gut. Pitx2c is a paired-like homeodomain transcription factor and is crucial for translating left-right signals into asymmetric morphogenesis. It is asymmetrically expressed in the left lateral plate mesoderm and continues to be expressed on
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Siontas, Dora. "The identification of proteins that interact with the N-terminal domain of Pitx2c." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106609.

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During embryogenesis, a number of key events regulate the correct patterning of an organism, one of them being the correct positioning of internal organs. One of the factors important for this process is the homeodomain transcription factor Pitx2c,which is asymmetrically expressed in the left lateral plate mesoderm. Previous work has shown that the N-terminal domain of Pitx2c is important for left-right patterning, in that overexpression of the N-terminus randomizes the direction of heart tube looping. It is believed that the overexpressed N-terminus is antagonizing the activity of endogenous
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Mechakra, Asma. "Étude cellulaire et moléculaire de quelques aspects de la fibrillation atriale et du syndrome du QT long : rôle des connexines 40 et 43, du facteur de transcription PITX2c et du canal potassique codé par KCNH2." Thesis, Lyon 1, 2014. http://www.theses.fr/2014LYO10005.

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La fibrillation atriale (FA) est l'arythmie cardiaque soutenue la plus fréquente chez les adultes. Elle est associée à une augmentation du risque d'accident vasculaire cérébral, d'insuffisance cardiaque et de la mortalité. Un mécanisme de torsades auriculaires a été décrit chez des patients atteints du syndrome du QT long congénital (SQTL). Malgré une littérature très riche sur le sujet, les mécanismes impliqués dans la genèse et le maintien de ces arythmies restent mal connus et constituent un obstacle dans le diagnostic et la prise en charge de ces maladies. Dans la première partie de ce tra
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Garric, Laurence. "Rôle de la voie Nodal et du facteur de transcription pitx2c dans la mise en place des asymétries neurales dans l'épithalamus du poisson zèbre." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2312/.

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Malgré notre apparente symétrie, il existe de nombreuses différences entre nos côtés gauche et droit tant au niveau de nos viscères qu'au niveau de notre cerveau. Ces asymétries neuroanatomiques sous-tendent des asymétries fonctionnelles et comportementales : le langage, par exemple, est un processus principalement réalisé dans l'hémisphère gauche. Des défauts dans la latéralisation (ou orientation droite ou gauche des asymétries) ont été corrélés à des désordres neuropathologiques comme la schizophrénie, l'autisme ou des maladies neurodégénératives. Il semble donc nécessaire d'étudier la mise
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Quentien, Marie-Hélène. "Différenciation des cellules du lignage antéhypophysaire somatolactotrope : un r^ole pour les facteurs de transcription Pitx1 et Pitx2." Aix-Marseille 2, 2002. http://www.theses.fr/2002AIX22080.

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Kulak, Stephen. "Mutational analysis of the homeobox transcription factor PITX2." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0021/MQ47053.pdf.

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Doerdelmann, Thomas. "Structural and Biophysical Studies of the Pitx2 Homeodomain." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1307443112.

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Fung, Khe Cheong Frederic, and 馮啟昌. "Upregulation of PITX2 transcription factor is associated with ovarian tumorigenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45988183.

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Kieusseian, Aurélie. "Etude du rôle du facteur de transcription Pitx2 dans la régulation de l'hématopoïèse." Paris 7, 2005. http://www.theses.fr/2005PA077147.

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Books on the topic "PITX2c"

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1934-, Pitxot Antonio, ed. Pitxot. Ambit, 1986.

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Museum, Can Framis, ed. Antoni Pitxot: La memòria i el temps. Fundació Vila Casas, 2014.

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Campione, Marina, Amelia Aranega, and Diego Franco. Cardiac looping and laterality. Edited by José Maria Pérez-Pomares, Robert G. Kelly, Maurice van den Hoff, et al. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757269.003.0014.

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Dextral looping is a complex process which progresses concomitantly with cardiac chamber differentiation and ultimately leads to the final alignment of the cardiac regions. Generation of cardiac asymmetry is crucial to ensure the proper form and consequent function of the heart and thus is a highly regulated process. Molecular signals originate long before morphological asymmetry and therefore can direct it; a complex regulatory network has been characterized which invariably converges on the Tgf-β‎ signalling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2. W
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Port engineering and operation. Thomas Telford Ltd, 1985. http://dx.doi.org/10.1680/pitnc.16194.

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Book chapters on the topic "PITX2c"

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Franco, Diego, and Amelia Aranega. "PITX2 (Pituitary Homeobox Gene 2)." In Encyclopedia of Signaling Molecules. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-67199-4_101670.

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Franco, Diego, and Amelia Aranega. "PITX2 (Pituitary Homeobox Gene 2)." In Encyclopedia of Signaling Molecules. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4614-6438-9_101670-1.

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Brown, Nigel A., Louisa M. Jones, Oliver A. T. Lyons, et al. "Pleiotropic Effects of Pitx2 Isoform C on Morphogenesis in the Mammalian Heart." In Cardiovascular Development and Congenital Malformations. Blackwell Publishing Ltd, 2007. http://dx.doi.org/10.1002/9780470988664.ch4.

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Hirano, Hisashi, and Brigitte Wittmann-Liebold. "Protein Microsequence Analysis with Dansylamino-PITC." In Methods in Protein Sequence Analysis. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73834-0_7.

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Smits, S. M., and M. P. Smidt. "The role of Pitx3 in survival of midbrain dopaminergic neurons." In Parkinson’s Disease and Related Disorders. Springer Vienna, 2006. http://dx.doi.org/10.1007/978-3-211-45295-0_10.

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Bell, Michael A., Kaitlyn E. Ellis, and Howard I. Sirotkin. "Pelvic Skeleton Reduction and Pitx1 Expression in Threespine Stickleback Populations." In Tinkering: The Microevolution of Development. John Wiley & Sons, Ltd, 2007. http://dx.doi.org/10.1002/9780470319390.ch15.

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Lemaire, Simon, and Serge Nolet. "Precolumn Derivatization of Peptides with Phenylisothiocyanate (PITC)." In Proteins. Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1787-6_6.

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Sadikot, Abbas F., Kelvin C. Luk, Pepijn van den Munckhof, et al. "Pitx3 is Necessary for Survival of Midbrain Dopaminergic Neuron Subsets Relevant to Parkinson’s Disease." In The Basal Ganglia VIII. Springer US, 2005. http://dx.doi.org/10.1007/0-387-28066-9_24.

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Choli-Papadopoulou, T., Y. Skendros, and K. Katsani. "A Manual Method for Protein Sequence Analysis Using the DABITC/PITC Method." In Protein Structure Analysis. Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59219-5_10.

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Wittmann-Liebold, Brigitte, Hisashi Hirano, and Makoto Kimura. "Manual Microsequence Determination of Proteins and Peptides with the DABITC/PITC Method." In Advanced Methods in Protein Microsequence Analysis. Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71534-1_8.

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Conference papers on the topic "PITX2c"

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"PITSaC 2013 Reviewers." In 2013 Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2013. http://dx.doi.org/10.1109/waina.2013.332.

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"PITSaC 2013 Organizing Committee." In 2013 Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2013. http://dx.doi.org/10.1109/waina.2013.331.

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"PITSaC 2014 Organizing Committee and Reviewers." In 2014 28th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2014. http://dx.doi.org/10.1109/waina.2014.193.

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"PITSaC 2016 Organizing Committee and Reviewers." In 2016 30th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2016. http://dx.doi.org/10.1109/waina.2016.214.

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"PITSaC 2015 Organizing Committee and Reviewers." In 2015 IEEE 29th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2015. http://dx.doi.org/10.1109/waina.2015.166.

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Bai, Jieyun, Yaosheng Lu, Andy C.Y. Lo, and Jichao Zhao. "PITX2 Overexpression Leads to Atrial Electrical Remodeling Linked to Atrial Fibrillation." In 2019 Computing in Cardiology Conference. Computing in Cardiology, 2019. http://dx.doi.org/10.22489/cinc.2019.002.

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"Message from the PITSaC 2016 Workshop Co-Chairs." In 2016 30th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2016. http://dx.doi.org/10.1109/waina.2016.213.

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"Welcome Message from the PITSaC 2014 Workshop General Chairs." In 2014 28th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2014. http://dx.doi.org/10.1109/waina.2014.192.

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"Welcome Message from the PITSaC 2015 Workshop General Chairs." In 2015 IEEE 29th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2015. http://dx.doi.org/10.1109/waina.2015.165.

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"Welcome Message from the PITSaC 2013 Workshop Co-Chairs." In 2013 Workshops of International Conference on Advanced Information Networking and Applications (WAINA). IEEE, 2013. http://dx.doi.org/10.1109/waina.2013.330.

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