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Dissertations / Theses on the topic 'PKC activator'

Author: Grafiati

Published: 4 June 2021

Last updated: 13 February 2022

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1

Douceau, Sara. "Implication du tPA cérébral dans la régulation des comportements et le remodelage des perineuronal nets Tissue-type plasminogen activator expressed in PKC-δ positive GABAergic neurons within the central amygdala modulates motor and emotional responses tPA originating from parvalbumin interneurons controls the remodeling of perineuronal nets". Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC423.

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L’activateur tissulaire du plasminogène (tPA) est une sérine protéase initialement décrite dans le compartiment vasculaire pour son rôle dans les processus de fibrinolyse. Le tPA est également retrouvé dans le parenchyme cérébral où il est exprimé par différents types cellulaires et notamment par les neurones. Cette protéase est impliquée dans de nombreuses fonctions cérébrales telles que la plasticité synaptique, la modulation de la neurotransmission glutamatergique et régule également les processus cognitifs et émotionnels. L’implication du tPA dans ces différentes fonctions est dépendante d

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2

Ettinger, Susan Lorraine. "Cytokine-induced activation of PKC isoenzymes in hemopoietic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27139.pdf.

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Cozzi, Sarah-Jane. "Molecular targets of anticancer PKC activators in the treatment of melanoma /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19185.pdf.

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4

Rourke, Bryan. "Characterization of the activation of PKC Apl II in Aplysia californica." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121492.

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PKC Apl II, a novel PKC in Aplysia californica, is required for reversal of depression, the cellular analog of behavioral dishabituation. The neurotransmitter 5HT activates PKC Apl II in sensory neurons and can induce the reversal of depression. Here we investigated the ability of 5HT to activate PKC Apl II and the molecular pathway involved. Reversal of depression can occur at concentrations as low as 1.6 μM. We observed that activation of PKC Apl II, as measured by membrane enrichment, can occur at similar concentrations (1 μM). Furthermore we observed differences in membrane enrichment in t

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5

Janoshazi, Agnès. "Study of activation process of protein kinase C (PKC) in living cells." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13064.

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Walker, Valerie Glynis. "Pl3-kinase mediates cSrc activation and podosome formation through the adaptor protein, AFAP-110, in response to PKC[alpha] activation." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5191.

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Thesis (Ph. D.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains viii, 306 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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7

Da, Lotti Dagan Ginette. "Détermination des pKa de la dézocine." Paris 5, 1995. http://www.theses.fr/1995PA05P024.

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8

Mazzucotelli, Anne. "Activation du métabolisme énergétique par le co-activateur PGC-1Alpha et implication du récepteur nucléaire PPAR Alpha dans l’adipocyte blanc humain." Toulouse 3, 2007. http://thesesups.ups-tlse.fr/40/.

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L’accumulation de tissu adipeux prédispose au développement d’un certain nombre de désordres métaboliques parmi lesquels l’insulino-résistance et le syndrome métabolique. Une des stratégies envisagées est de convertir les adipocytes blancs en adipocytes présentant un phénotype oxydatif similaire à celui des adipocytes bruns. L’activation de la béta-oxydation et de la thermogenèse permettrait d’augmenter la dépense énergétique tout en utilisant les acides gras libérés par la lipolyse. Récemment, l’équipe a montré que la sur-expression de PGC1alpha dans des cultures primaires d’adipocytes blancs

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Cheng, Cecilia Yuen-Man. "Dissecting the allosteric regulation of PKA-I alpha activation." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3355645.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed June 23, 2009). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 200-214).

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10

Fillmore, Natasha. "Chronic AMP-Activated Protein Kinase Activation and a High-Fat Diet Have an Additive Effect on Mitochondria in Rat Skeletal Muscle." BYU ScholarsArchive, 2010. https://scholarsarchive.byu.edu/etd/2548.

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Factors that stimulate mitochondrial biogenesis in skeletal muscle include AMPK, calcium, and circulating FFAs. Chronic treatment with either AICAR, a chemical activator of AMPK, or increasing circulating FFAs with a high fat diet increases mitochondria in rat skeletal muscle. The purpose of this study was to determine whether the combination of chronic chemical activation of AMPK and high fat feeding would have an additive effect on skeletal muscle mitochondria levels. We treated Wistar male rats with a high fat diet (HF), AICAR injections (AICAR), or a high fat diet and AICAR injections (HF+

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11

Allan, Robert. "Mechanistic control of the cold-induced augmentation of the transcriptional co-activator PGC-1α". Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/7178/.

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Cold water immersion is commonly used to alleviate the stress and damage that ensues following strenuous exercise. Alongside its purported performance and analgesic benefits recent literature highlights the positive impact it may have towards endurance adaptive responses, particularly on key markers of mitochondrial biogenesis. Despite these recent advances showing PGC-1α, the ‘master regulator’ of mitochondrial biogenesis, being augmented in its post-exercise response by cold water immersion, the precise controlling mechanisms remain to be determined. However, it has been suggested that local

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12

Boufroura, Fatima-Zohra. "Effets du GSK773, un activateur de l'AMPK, sur le métabolisme et la différenciation de cellules musculaires déficitaires en carnitine palmitoyl tranférase 2 (CPT2)." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCB002.

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Le déficit héréditaire en Carnitine Palmitoyl Transférase 2 (CPT2), l’un des déficits de l’oxydation mitochondriale des acides gras (OAG) les plus fréquents, est caractérisé dans sa forme adulte par une myopathie métabolique avec des épisodes récurrents de douleurs musculaires, de myoglobinurie et de rhabdomyolyse, habituellement déclenchés par un exercice prolongé ou un jeûne. A l’heure actuelle, il n’y a pas de traitement pharmacologique efficace pour la correction de ce déficit à l’exception de prise en charge nutritionnelle. Mon travail de thèse a porté sur l’étude du potentiel thérapeutiq

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Mischuk, Bradley. "SAP102 Switches the Mechanism of D₁R-Mediated ERK1/2 Activation from a PKA-Independent to PKA-Dependent Pathway." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41526.

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Hyperactivation of extracellular signal-regulated kinase 1 and 2 (ERK1/2) by dopamine D₁ receptor (D₁R) in the striatum is a characteristic feature of several neuropsychiatric conditions, including drug addiction and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) within individuals suffering from Parkinson’s disease. However, the current mechanistic gap in understanding of D₁R-mediated regulation of ERK1/2, both in physiology and disease, hampers effective treatment of these conditions. One important factor that is underexplored in this regard is the role played by proteins tha

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Souza, João Ricardo Malheiros de. "Injeção intracitoplasmática de espermatozoide: métodos de ativação oocitária e desestabilização da membrana espermática." Universidade Federal de Santa Maria, 2017. http://repositorio.ufsm.br/handle/1/11701.

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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>Development of bovine embryos produced by intracytoplasmic sperm injection (ICSI) is low compared to fertilized embryos. Deficient oocyte activation, inappropriate sperm capacitation, and lack of sperm decondensation are thought to be the main constrains affecting ICSI success in cattle. In the present study, activation compounds were tested to establish an effective protocol for activation of bovine oocytes, and then used for oocyte activation after ICSI. The activation approach consisted of exposing in vitro m

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Jethwa, N. "The role of polyphosphoinositides in Akt/PKB activation dynamics in subcellular compartments." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1416416/.

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The phosphonoinosites play structural and functional roles in biological membranes; reversible phosphorylation of the inositol headgroup generates seven different headgroups which are involved in defining organelle identity and regulating signalling, trafficking and cytoskeletal integrity. The serine/ threonine kinase Akt lies at the heart of cell biology. It is activated by an interaction with the phosphoinositide PtdIns(3,4,5)P3 in response to growth factor stimulation. Akt controls cell growth, proliferation, survival and energy metabolism. Misregulated Akt activity is a hallmark of many di

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Tao, Jing-Song. "Activation of stress-activated kinases and inhibition of PJ 3-K/PKB and p70§s§6§k mitogenic signaling pathway by photodynamic therapy in murine keratinocytes." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27258.pdf.

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Brown, Louise E. "Role of human Desmoglein 3 in the regulation of cell morphology and motility via AP-1 and PKC dependent Ezrin activation." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/26964.

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Desmoglein 3 (Dsg3) belongs to the desmoglein subfamily and functions as an adhesion molecule in desmosomes. Two pools of Dsg3 have been identified, detergent soluble and insoluble proteins. Recent studies show that DSG3 is upregulated in squamous cell carcinoma (SCC). However, its biological function in cancer remains poorly understood. The aim of this study was to investigate the extra-junctional functions of Dsg3, in particular its roles in signalling that regulates cell morphology and locomotion in cancer cells. This study adopted a unique cancer cell model with Dsg3 gain-of-function and h

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18

Junoy, Brice. "Expression et régulation (activation, dégradation) des isoformes (alpha, epsilon, delta) de la PKC dans deux lignées gonadotropes αT3-1 et LβT2". Aix-Marseille 2, 2003. http://www.theses.fr/2003AIX22043.

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19

Plo, Isabelle. "Activation des voies anti-apoptotiques par les ligands de mort et les médicaments antitumoraux." Toulouse 3, 2002. http://www.theses.fr/2002TOU30048.

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20

Kelly, Joanna. "Non-canonical PKCε activation is required for the cellular response to TopoIIα inhibition". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10045030/.

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The cell cycle is tightly regulated to safeguard the complete and equal division of the nuclear contents between the daughter cells. To ensure accurate segregation of the chromatin, DNA catenation generated during replication must be resolved by topoisomerase IIα (TopoIIα). In some tumour-derived cells, Protein kinase C epsilon (PKCε) has been shown to play a crucial role in mediating a delay signal at the metaphase-to-anaphase transition when catenation is still present, allowing time for catenation resolution prior to anaphase entry and sister chromatid separation. PKCε has also been shown t

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Charles, Joseph William. "Studies On The Molecular Mechanism Of S-Tide Mediated Activation Of Pkg-Iα". ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1005.

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cGMP-dependent protein kinases (PKG) are key players in intracellular second messenger signaling within many cellular systems throughout the body. Most notably PKG is known for its role in smooth muscle relaxation (Pfeiffer et.al, 1999). The Iα PKG isozyme has been identified as the primary effector of the nitric oxide pathway (and serves to be a novel drug target). To date the overall knowledge of structure and function of PKG is lacking in terms of the mechanisms of activation and the structural orientations that coordinate them. Recently, our laboratory has solved the crystal structure of t

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Garaude, Johan. "Activation et régulation de ERK5 et AP-1 dans les lymphocites T et les leucémies." Montpellier 2, 2007. http://www.theses.fr/2007MON20053.

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23

Karimi, Gilda. "Etude de l'assemblage de la NADPH oxydase du phagocyte." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112025.

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La NADPH oxydase du phagocyte est une enzyme impliquée dans la défense immunitaire contre les pathogènes. Après activation du phagocyte, cette enzyme produit des ions superoxyde par réduction du dioxygène par le NADPH. Elle est constituée de quatre sous- unités cytosolubles (p47phox ; p67phox ; p40phox et Rac), et deux membranaires (gp91 ; p22phox). Son activation fait intervenir un processus complexe qui met en jeu des changements d’interaction entre les protéines la constituant et qui permet l’assemblage des six sous- unités. Afin d’obtenir des informations sur les processus d’assemblage et

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Huang, Xuesong. "The Study on Signal Mechanism of Protein Kinase C zeta-involved NF-κB Activation in LPS-stimulated TLR4 Signaling Pathways". University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1193663177.

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25

Subramaniam, Rajagopal. "Identification and characterization of a PKC-like kinase in potato and its role in the activation of the defense response gene PR-10a." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0008/NQ42281.pdf.

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26

Aljagthmi, Amjad Ahmed. "The regulation of small GTPase Rac1 phosphorylation, activation and subcellular localization by ΔNp63α". Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1629746909185699.

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Isabel, Londono Cristina. "Assessment of causes of irreversible fouling in powdered activated carbon/ultrafiltration membrane (PAC/UF) systems." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37066.

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Powdered Activated Carbon (PAC) has been successfully used in conjunction with membrane ultrafiltration (UF) to reduce taste, odour, colour and other concerns caused by organic material present in raw drinking water sources. PAC addition also typically significantly reduces the extent of fouling in hybrid PAC/UF systems. However, in some cases, PAC addition can have a significant negative effect by increasing irreversible membrane fouling. The present study was developed to assess the cause of irreversible fouling in a system for which PAC addition had a negative effect. The first part of th

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Caligtan, Marc J. "Ischemic Preconditioning Protects Adult Rat Cardiomyocytes Against Necrosis but not Apoptosis, via Activation of PKG." VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/1442.

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The role of cyclic guanosine monophosphate (cGMP) dependent protein kinase (PKG) in necrotic and apoptotic pathways of many cell types is well established; however its role in the ischemic preconditioning (IPC) of cardiomyocytes is not clearly defined. In the current study, we assessed the hypothesis that PKG protects against cell death following ischemidreperfusion injury in myocytes subjected to IPC. Freshly isolated adult rat ventricular myocytes were subjected to IPC by incubating in ischemic buffer for 30 minutes (min) followed by incubation in normal medium for 30 min. Prolonged simulate

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Sorouri, Shagahyegh. "Incorporation Of Fluorescence Measures To Model Treated Water Quality And Assess PAC Performance." University of Akron / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=akron1597345883338139.

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Sousa, Daniela Alexandra Costeira de. "Stimulation of a pDC cell line with self-DNA immune complexes." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22095.

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Mestrado em Biomedicina Molecular<br>Plasmacytoid dendritic cells (pDCs) are a subset of Dendritic Cells that when stimulated can produce pro-inflammatory mediators and type I IFNs. These cells play an important role in autoimmune disease such as systemic lupus erythematosus, as they can become activated by immune complexes formed with self-DNA, which trigger a type I IFN response through the TLR-9 signaling pathway. Here, we optimized activation of CAL-1 cells, a human pDC cell line, with immunocomplexes of self-nuclear or mitochondrial DNA with the antimicrobial peptide LL37. It was f

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Sheehe, Jessica Lynne. "The A-Site In The Pkg Iα Regulatory Domain Controls Both Cgmp- And Oxidative-Dependent Activation". ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/950.

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The type Iα cGMP-dependent protein kinase (PKG Iα) is an essential regulator of vascular tone and systemic blood pressure. Located in the smooth muscle of resistance vessels, PKG Iα stimulates vasodilation through the phosphorylation of multiple intracellular substrates. Its primary regulator is the small molecule, 3',5'-cyclic guanosine monophosphate (cGMP); however, the Iα isoform can also be activated by oxidation. Despite the established physiological importance of PKG Iα, the structural underpinnings of these two activation mechanisms are largely unknown. The work presented in this disser

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Stoquart, Céline. "Performance of aged PAC suspensions in a hybrid membrane process for drinking water production." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209254.

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Les procédés membranaires hybrides (PMH) allient la filtration membranaire basse pression à l’usage du charbon actif en poudre (CAP). Afin de diminuer les coûts opérationnels du procédé, il a été proposé de laisser vieillir le CAP dans le PMH et donc de minimiser le dosage de CAP frais. Peu d’information est disponible quant à la capacité résiduelle d’adsorption de suspensions de CAP âgées. L’importance relative de l’adsorption et de la biodégradation dans les réacteurs à CAP âgés sur le traitement des composés dissous est inconnue, ce qui empêche notamment l’optimisation du procédé. <p><p>Le

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Bertrand, Florie. "Polarisation à la synapse immunologique de la machinerie sécrétoire des lymphocytes T : mécanismes moléculaires et impact sur la cellule présentatrice d'antigène." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1099/.

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La rencontre entre un lymphocyte T (LT) et une cellule présentatrice d'antigène (CPA) induit la formation d'une aire spécialisée, à l'interface cellulaire, appelée synapse immunologique (SI) ainsi que la polarisation de la machinerie sécrétoire (MTOC et appareil de Golgi) du LT vers la CPA. Si ce phénomène de polarisation est bien caractérisé, ses mécanismes moléculaires et son impact sur l'activation de la CPA sont encore largement inconnus. Mon travail de thèse a contribué à fournir des réponses à ces deux questions. Tout d'abord, nous avons démontré que la protéine kinase C zeta (PKC zeta),

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Githure, George B. [Verfasser], and Michael [Akademischer Betreuer] Boshart. "Evolutionary divergent ligand activation of PKA-like kinase from Trypanosoma brucei / George B. Githure ; Betreuer: Michael Boshart." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1122435908/34.

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Dunn, Timothy Alan. "The link between neuronal activity and activation of the cAMP/PKA cascade in developing retinal ganglion cells." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2008. http://wwwlib.umi.com/cr/ucsd/fullcit?p3311360.

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Thesis (Ph. D.)--University of California, San Diego, 2008.<br>Title from first page of PDF file (viewed July 30, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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Wang, Jianwei. "Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus". Kyoto University, 2019. http://hdl.handle.net/2433/242392.

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Traboulsi, Hussein. "Relationship between the transcription/DNA repair factor TFIIH and the Peroxisome Proliferator-Activated Receptor coactivator 1α PGC-1α". Strasbourg, 2011. http://www.theses.fr/2011STRA6063.

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Des mutations dans la sous unité XPD du facteur de transcription IIH (TFIIH) conduit à des maladies génétiques rares incluant trichothiodystrophy TTD. Connaissant que la sous unité MAT1 de TFIIH est nécessaire pour une activité complète de l’activateur proliferator activated receptor g coactivator 1a (PGC-1a), on a décidé de regarder l’influence de la mutation R722W dans XPD sur l’activité de PGC-1a dans les hépatocytes TTD. Nos résultats montrent que le facteur transcriptionnel TFIIH est nécessaire pour l’activité hépatique du cofacteur PGC-1α dans la voie de la néoglucogenèse. En plus on mon

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Lind, Liza. "Non-coding RNA in T cell activation and function." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96966.

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For a long time research has focused on the protein-coding mRNA, but there is a complex world of non-coding RNAs regulating the human body that we yet know very little about. Non-coding RNAs (ncRNAs) are involved in modulation of different cell processes including proliferation, differentiation and apoptosis. In the current study the role of ncRNAs in T cell activation and function was investigated. T cells are important mediators of immune responses, for example upon viral infections. The T helper cells (TH or CD4+ cells) are involved in orchestrating immune processes like aiding the activati

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Cucchetti, Margot. "Rltpr, a lymphoid-specific protein essential for CD28 costimulation." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4043.

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La reconnaissance d'antigènes par le TCR active des protéines tyrosine kinases qui phosphorylent d'autres substrats intracellulaires dont LAT. Ceci engendre l'activation de molécules telles que PKCθ et CARMA-1. La mutation LatY136F associe des TCR "estropiés" dans le développement de cellules T effectrices générant des désordres lymphoprolifératifs. Nous avons essayé de comprendre les gènes aggravant ou empêchant cette lymphoprolifération en utilisant la mutagénèse ENU. Nous avons identifié une mutation appelée Basilic empêchant le déroulement de la pathologie LatY136F. Basilic est une mutatio

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Dickerman, Benjamin K. "THE PHYSIOLOGICAL FUNCTION OF THE dsRNA-BINDING PROTEIN PACT/RAX, PROTEIN ACTIVATOR OF PKR AND ITS ROLE IN MOUSE DEVELOPMENT." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1335901974.

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Duquesnes, Nicolas. "Signalisation cellulaire et formation de complexes protéiques lors de l'étirement des cardiomyocytes de rats nouveaux-nés." Phd thesis, Université Paris-Est, 2008. http://tel.archives-ouvertes.fr/tel-00842230.

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L'étirement est un stimulus hypertrophique qui active de nombreuses voies de signalisation similaires à celles mises en évidence lors de l'étude de l'hypertrophie cellulaire. L'objectif principal de mon travail de thèse était de caractériser les évènements moléculaires impliqués dans l'activation des MAPKinases (MAPK), ERK et JNK lors de l'étirement. Nous avons étudié ces protéines par 2 approches différentes. D'une part, nous nous sommes intéressés aux rôles de protéines potentiellement nécessaires à l'activation des MAPK. D'autre part, nous avons cherché à mettre en évidence des interconnexi

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Hatt, Juliette W. "Pretreatment options for municipal wastewater reuse using membrane technology." Thesis, Cranfield University, 2012. http://dspace.lib.cranfield.ac.uk/handle/1826/10200.

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Increasing freshwater scarcity across the world means that wastewater reclamation is being considered as a key method in which to meet the growing demand. Evolution of water reuse schemes where high quality product is required such as for indirect potable reuse has led to the adoption in recent years of the integrated membrane scheme using a combination of microfiltration or ultrafiltration with reverse osmosis membrane. However, despite technological advancements, these membranes are still prone to fouling resulting in increased costs through cleaning or replacement. This thesis aims to look

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Thiagarajan, Praveena S. "VIMENTIN IS A PHOSPHORYLATED TARGET OF MCP-1-INDUCED PKCβ ACTIVATION AND AN ENDOGENOUS LIGAND FOR THE INNATE IMMUNE RECEPTOR DECTIN-1". Kent State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=kent1399566096.

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Nausch, Lydia. "Novel Insights into PKG Activation and cGMP Signaling in Response to Nitric Oxide and Atrial Natriuretic Peptide in Vascular Smooth Muscle Cells." ScholarWorks @ UVM, 2008. http://scholarworks.uvm.edu/graddis/158.

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Cyclic 3',5'-guanosine monophosphate (cGMP) is a key signaling molecule involved in a myriad of physiological processes, including vascular smooth muscle (VSM) tone, water- and electrolyte homeostasis, platelet aggregation, airway smooth muscle tone, smooth muscle proliferation and bone formation. Increased occurrence of vascular disorders including erectile dysfunction, hypertension, stroke and coronary artery disease, have made it increasingly important to study the dynamic interplay between cGMP synthesis and hydrolysis in VSM cells. This dissertation examines the spatial distribution of in

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Branvold, Devon Jack. "Regulation of LKB1-STRAD-MO25 Complex Expression and Activation of AMPK in Skeletal Muscle by Thyroid Hormone." BYU ScholarsArchive, 2007. https://scholarsarchive.byu.edu/etd/1407.

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AMP-activated protein kinase (AMPK), a heterotrimeric protein which serves as a metabolic master switch in skeletal muscle, is a research target for the pharmaceutical treatment and prevention of type 2 diabetes. The expression of all of the isoforms of the subunits of AMPK and AMPK activity are increased in skeletal muscle tissue of hyperthyroid rats. Activity of AMPK is regulated by an upstream kinase (AMPKK). The LKB1-STRAD-MO25 complex is a major AMPKK in skeletal muscle. This experiment was designed to determine whether the increase in AMPK activity is accompanied by a thyroid hormone-ind

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Milord, Sandrine. "Contribution à l’étude du rôle et de la régulation de Fra-1 dans le cancer." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON13505/document.

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Fra-1 appartient à la famille des facteurs de transcription AP-1. Son expression est particulièrement élevée dans les cellules de cancer du sein qui n'expriment pas le récepteur aux œstrogènes (RE-), c'est-à-dire les cellules les plus agressives. L'inhibition de Fra-1 dans ces cellules entraîne une diminution de la motilité, de l'invasion et de la prolifération, mais elle entraîne aussi de profonds changements de morphologie. Les cellules RE-, qui présentent un phénotype mésenchymateux s'arrondissent et établissent un plus grand nombre de contacts cellule-cellule après l'inhibition de Fra-1. D

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Kårehed, Karin. "Signal Transduction in Malignant Cells – Transformation, Activation and Differentiation." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6346.

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<p>All aspects of cell life are regulated by signal transduction mechanisms. This thesis describes the regulatory roles of a few key signal transduction molecules involved in three major biological responses. The studied pathways include platelet derived growth factor (PDGF)-BB induced transformation of murine fibroblasts, interferon (IFN)-γ stimulated monocyte activation and all-trans retinoic acid (ATRA) induced myeloid differentiation. </p><p>We found that intact phosphoinositide 3OH-kinase (PI3K) activity is essential in the signaling pathway that leads to the morphological alterations an

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Gopala, Krishna Nishanth Verfasser], and Dirk [Akademischer Betreuer] [Schlüter. "Regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-[kappa]B) by protein Kinase C theta (PKC-[theta]) and cylindromatosis (CYLD) in murine listeriosis and toxoplasmosis / Nishanth Gopala Krishna. Betreuer: Dirk Schlüter." Magdeburg : Universitätsbibliothek, 2013. http://d-nb.info/1054421196/34.

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Inoue, Takahiro. "Requirement of androgen-dependent activation of PKCζ for androgen-dependent cell proliferation in LNCaP cells and its roles in transition to androgen-independent cells". Kyoto University, 2007. http://hdl.handle.net/2433/135744.

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Balzer, Michael S. [Verfasser], та Jörg H. W. [Akademischer Betreuer] Distler. "Die Rolle von Peroxisome Proliferator-Activated Receptor gamma Coactivator-1alpha (PGC-1α) in der Pathogenese der Sklerodermie / Michael S. Balzer. Betreuer: Jörg H. W. Distler". Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2012. http://d-nb.info/1025963830/34.

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