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Dissertations / Theses on the topic 'PKC'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Plammootil, Suma Mary. "Herstellung und Etablierung von 4-Hydroxytamoxifen aktivierbaren PKC[alpha]- [PKC alpha]-, PKC[beta]1- [PKC beta1] und PKCd--Fusionsproteinen [PKC delta-Fusionsproteinen]." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971703302.

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2

Snider, Adam K. "PKC gamma regulates connexin 57." Thesis, Manhattan, Kan. : Kansas State University, 2010. http://hdl.handle.net/2097/4128.

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3

Bahte, Svenja-Katharina Paula. "Identifikation neuer Bindungspartner von PKC- d [PKC-delta] mit Hilfe des Yeast-two-hybrid-Screens." [S.l.] : [s.n.], 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013081490&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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4

Cheng, Sam Xian Jun. "Functional significance of phosphorylation of rat renal Na+,K+-ATPase by PKA and PKC /." Stockholm, 1998. http://diss.kib.ki.se/1998/91-628-2971-8.

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5

Quittau-Prévostel, Corinne. "Mutant D294G de la PKC[alpha] tumorigénèse humaine : la PKC[alpha], un nouveau suppresseur de tumeur." Montpellier 1, 1997. http://www.theses.fr/1997MON1T005.

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6

ZINI, SILVIA. "PKC: Paffard Keatinge-Clay architetto itinerante." Doctoral thesis, Università IUAV di Venezia, 2015. http://hdl.handle.net/11578/278352.

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7

Worthmann, Kirstin [Verfasser]. "Die Rolle der atypischen Protein Kinase C Isoformen PKC[lambda]/[iota] und PKC[zeta] in Podozyten / Kirstin Worthmann." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover, 2011. http://d-nb.info/1012625508/34.

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8

Cabrerizo, Benito Yolanda. "Studies on a PKC-PLD-MAPK pathway." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399767.

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9

Kostelecky, B. D. "An investigation of PKC isoform functional specificity." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18705/.

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Protein kinase C (PKC) isozymes are vital signalling proteins in many intracellular processes including cell survival, proliferation and migration. As such, changes in their expression levels have been linked to many types of cancer. The various PKC family members provoke differential responses in cancer highlighting the need for study of individual isoforms. This investigation of PKC has aimed to determine how kinase domain structure, regulatory region interactions and binding partners confer functional specificity to individual PKC isoforms. X-ray crystallographic, biochemical and biophysica

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10

Peel, N. R. "Dissecting compartmentalised atypical PKC controls in cell migration." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1419046/.

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Atypical Protein Kinase C (aPKC) isoforms are essential regulators of polarised cell behaviour and in migrating NRK cells translocate to the leading edge in a complex with the exocyst and KIBRA. Engineered delivery of upstream signals to the plasma membrane places leading edge ERK activation downstream of aPKC and demonstrates partial sufficiency in regulating cell migration and adhesion. This model system provides the opportunity to probe the leading edge to better understand events downstream of aPKC. Multiple screening approaches have identified cytoskeletal and translation processes as put

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11

Gumpert, Nicolas Maximilian. "Funktionale Bedeutung der Protein Kinase C - d [C - delta] (PKC - d) [(PKC - delta)] in der Reorganisation der zytoskelettären Architektur humaner Keratinozyten." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=964885824.

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12

Qian, Yu. "Analyser le gène PKC-2 chez Caernorhabditis elegans et crible les mutants contre sérotonine chez le C. elegans souche pkc-2 (ok328)." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00712129.

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La myopathie de Duchenne est une maladie génétique qui se caractérise principalement par une dégénérescence progressive des muscles squelettiques dont la cause est l'absence de dystrophine fonctionnelle dans les muscles. A ce jour, il n'existe toujours pas de traitement efficace contre ces maladies. Comme le plus grand gène connu chez l'Homme, la dystrophine code pour une protéine de 427kDa. La protéine connecte l'actine avec le DAPC (Dystrophin Associated Protein Complex) dans les muscles striés. Pour l'instant, il y a 3 hypothèses concernant le mécanisme du DMD. L'absence de la dystrophine p

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13

Aaltonen, V. (Vesa). "PKC and neurofibromin in the molecular pathology of urinary bladder carcinoma:the effect of PKC inhibitors on carcinoma cell junctions, movement and death." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285899.

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Abstract This study examined the role of tumor suppressor neurofibromin and Protein kinase C (PKC) in urinary bladder cancer, and the effect of PKC inhibitors on cancer cell behaviour. Tumor suppressor protein neurofibromin is a product of the NF1 gene, a mutation of which causes the most common hereditary tumor syndrome, type 1 neurofibromatosis. NF1 gene mutations and changes in expression have been demonstrated in malignancies, unrelated to type 1 neurofibromatosis. The best known function of neurofibromin is its Ras GTPase accelerating function. Thus, it functions as a Ras inactivator. T

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14

Hessabi, Tarik. "Über die Rolle von PKC epsilon während der Wundheilung." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=977243265.

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15

Garratt-Lalonde, Michelle. "The role of atypical PKC iota in glioblastoma multiforme." Thesis, University of Ottawa (Canada), 2003. http://hdl.handle.net/10393/26484.

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Glioblastoma multiforme, a high grade malignant astrocytoma, is the most common and mortal intracranial tumor in adults. The median survival time for glioblastoma patients remains from 9--12 months despite aggressive treatment programs. These high-grade central nervous system tumors bear genetic and molecular aberrations that result in innate chemoresistance to commonly used chemotherapeutic agents. The main focus of this thesis is on exploring signaling events downstream of phosphoinositide 3-kinase (PI3-K) in glioblastoma multiforme in attempts to discover molecular targets that may be highl

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16

Ettinger, Susan Lorraine. "Cytokine-induced activation of PKC isoenzymes in hemopoietic cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ27139.pdf.

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17

Nakagawa, Rinako. "Role of PKC during B cell development and transformation." Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/9056/.

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The objective of this thesis is to determine the role of specific PKC isotypes during B cell development and transformation. B cell generation systems were validated both in vitro and in vivo, by coculturing haematopoietic progenitor cells (HPCs) on the calvanial cell line, 0P9, or by adoptively transferring HPCs into recombinase-activating gene 1-deficient (RAG-1-/-) mice, respectively. In both cases, mature B cells were generated as determined by analysing surface B cell marker expression. Coupling of these in vitro and in vivo B cell generation systems with a retroviral gene transfer techni

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18

Guerra, Gustavo Petri. "A melhora da memória induzida por espermidina envolve a fosforilação da pkc, pka e creb em hipocampo de ratos." Universidade Federal de Santa Maria, 2011. http://repositorio.ufsm.br/handle/1/4431.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>The endogenous poliaminas, putrescine, spermidina and spermine are aliphatics amines that are present in high concentrations in the central nervous system (SNC). The action of the poliamines involves the modulation of several ionic channels, including the subtype of glutamatergic N-methyl-D-aspartate receptor (NMDA). The processes mediated by NMDA receptor include synaptic plasticity and formation of neural circuitry. It is believed that these plasticities happening in some cerebral areas specifies, as the hippocampus, are critical

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19

Dykes, Ava Caudill. "Diverse roles of PKC[alpha] in vascular smooth muscle contraction." Huntington, WV : [Marshall University Libraries], 2006. http://www.marshall.edu/etd/descript.asp?ref=680.

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Theses (Ph. D.)--Marshall University, 2006.<br>Title from document title page. Includes abstract. Document formatted into pages: contains xiii, 122 p. including illustrations. Bibliography: Chap.I. p.28-33; Chap. II. p. 82-86; Chap. III p.115-116.

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20

Brandt, Dominique. "Über die Rolle von PKC bei der Reorganisation des Zytoskeletts." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968536875.

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21

Hall, Kellie Joann. "The Regulation and Role of Novel PKC Isoforms in Platelets." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486072.

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Platelets are central to physiological haemostasis and respond to stimulation by a variety of soluble and insoluble agonists. Most platelet activatory agonists couple to activation of protein kinase C (PKC) isoforms, including PKC8 and PKCe, members of the novel PKC family. So far the role of PKC8 in platelets has been fairly well characterised although its regulation in platelets, particularly by phosphorylation, is less well understood. Conversely the role of PKCe is less well understood due to a lack of selective inhibitors. This thesis aimed to investigate the regulation ofPKC8 by tyrosine

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22

Clelland, Lyndsay Jacquelyn. "Role of ROK and PKC in Permeabilized Rabbit Femoral Artery." VCU Scholars Compass, 2007. http://hdl.handle.net/10156/1581.

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23

Rao, Sudha. "Identification and characterisation of a novel form of PKC-zeta." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312797.

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24

Scott, Hannah Elizabeth. "PKC-δ, its C2 domain and breast cancer cell lines". Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12668/.

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Protein kinase C δ (PKC-δ) is a novel member of the PKC family of serine-threonine kinases. PKC-δ structure is widely conserved within the PKC family and has a catalytic region and regulatory region. The regulatory region has two main sub domains C1 and C2. Although several studies have investigated the role of the C1 domain, little is known about the function of the C2 domain, however there is some evidence that it acts as a protein interaction domain. PKCs are involved in a wide variety of cellular functions within cancer. PKC-δ has been demonstrated to have a particular involvement with the

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25

FABRE, SERGE. "Conception et synthese d'inhibiteurs de la proteine kinase c (pkc)." Clermont-Ferrand 2, 1993. http://www.theses.fr/1993CLF21572.

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A travers la conception et la synthese de nouveaux inhibiteurs de la pkc, nous avons voulu mettre en evidence la correlation existant entre pouvoir inhibiteur sur la pkc et la suppression de differentes reponses biologiques resultant de l'activation de l'enzyme, telles la vasoconstriction ou la proliferation cellulaire, dans le but de mettre a jour d'eventuels principes actifs utilisables en therapeutique antihypertensive ou anticancereuse. L'ouvrage comporte trois volets, en plus d'une partie experimentale. La premiere partie est une etude bibliographique tres complete, presentant des general

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26

Mayanglambam, Azad. "Regulation of Protein Kinases (Syk and PKC zeta) in platelets." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/91635.

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Physiology<br>Ph.D.<br>Platelets are crucial components of the hemostatic machinery of the body. When the endothelial continuity is disrupted due to injury or atherosclerotic plaque rupture, one of the earliest responses to arrest the bleeding is the adhesion of circulating platelets to the exposed subendothelial collagen matrix. Subsequent intracellular signaling mediated downstream of various receptor systems leads to alpha IIb beta 3 activation, thromboxane generation, ADP release, etc., culminating in platelet clot or thrombus formation. The protein kinase family of enzymes mediates a sign

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27

Roberts, Sarah Anne. "An investigation of protein kinase C in Swiss 3T3 cells using phorbol esters." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369190.

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28

Trachsel, Sébastien Auguste Charles. "Selective responses (Actin polymerization, shape changes, locomotion, pinocytosis) to the PKC-inhibitor Ro 31-8220 suggest thath PKC discriminately regulates functions of human blood lymphocytes /." [S.l : s.n.], 1996. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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29

Cozzi, Sarah-Jane. "Molecular targets of anticancer PKC activators in the treatment of melanoma /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19185.pdf.

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30

Tränkle, Jens. "Mechanismen der Signalübertragung durch PKC und Rho in Hefe und Säugern." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968798187.

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31

Humphries, Michael Jason. "PKC[delta] and apoptosis : analysis of the role of tyrosine phosphorylation /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Cell and Developmental Biology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 155-180). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

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32

Burstin, von Vivian Annaluise. "PKC isozymes in the control of fate of prostate cancer cells." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-127021.

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33

Al-Kushi, Abdullah Glil. "Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat." Connect to e-thesis, 2007. http://theses.gla.ac.uk/149/.

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Thesis (Ph.D.) - University of Glasgow, 2007.<br>Ph.D. thesis submitted to the Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, 2007. Includes bibliographical references.

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34

Rourke, Bryan. "Characterization of the activation of PKC Apl II in Aplysia californica." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121492.

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PKC Apl II, a novel PKC in Aplysia californica, is required for reversal of depression, the cellular analog of behavioral dishabituation. The neurotransmitter 5HT activates PKC Apl II in sensory neurons and can induce the reversal of depression. Here we investigated the ability of 5HT to activate PKC Apl II and the molecular pathway involved. Reversal of depression can occur at concentrations as low as 1.6 μM. We observed that activation of PKC Apl II, as measured by membrane enrichment, can occur at similar concentrations (1 μM). Furthermore we observed differences in membrane enrichment in t

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35

Al-kushi, Abdullah G. "Pathological changes in mesostriatal neurons in a PKC-gamma mutant rat." Thesis, University of Glasgow, 2008. http://theses.gla.ac.uk/149/.

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The AS/AGU rat originated as a recessive mutation (agu) in a closed colony of Albino Swiss (AS) rats. The mutation is in the gene coding for the gamma isoform of protein kinase C. It is characterized by movement impairments and progressive dysfunction of the nigrostriatal dopaminergic (DA) and raphe striatal serotonergic (5-HT) systems. The movement impairments including rigidity of the hind limbs, a staggering gait, a tendency to fall over every few steps, a slight whole body tremor and difficulty in initiating movements. The dysfunction in both systems is characterised by a failure to releas

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36

Omri, Samy. "Etude du rôle de la PKC Zeta dans la rétinopathie diabétique." Paris 5, 2010. http://www.theses.fr/2010PA05T033.

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La rétinopathie diabétique (RD) est la première cause de cécite chez les patients de moins de 60 ans. La formation d'oedème due à une altération des barrières oculaires et l'inflammation sont souvent associées à cette pathologie. Au cours du diabète, la PKC zeta joue un rôle prépondérant à différents niveaux ; comme le transport du glucose, la résistance à l'insuline, et la migration des macrophages au cours de l'inflammation oculaire. Mon travail a porté sur l'étude du rôle de la PKC zeta dans les mécanismes moléculaires impliqués dans ces altérations au cours du diabète de type 2 chez le rat

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37

de, Souza Figueiroa Marina. "Efeito do extrato aquoso do chá verde e suas catecinas puras sobre a produção de testosterona pelas células de Leydig de rato in vitro." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/2139.

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Made available in DSpace on 2014-06-12T15:54:51Z (GMT). No. of bitstreams: 2 arquivo607_1.pdf: 1573923 bytes, checksum: 64f355c17fab0797315fdf979c778510 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008<br>Faculdade Intergrada do Recife<br>Este estudo investigou os efeitos agudos do extrato aquoso do chá verde (GTE) e dos seus constituintes polifenóis (-)-epigalocatecina-3-galato (EGCG) e (-)-epicatecina (EC) sobre a produção de testosterona basal e estimulada, em células de Leydig de ratos in vitro. Células de Leydig purificadas for

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38

Nguyen, Loan Thi Kim. "Role of PKC-mediated phosphorylation on p53 localization and function in neuroblastoma." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27279.

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Neuroblastoma (NB) is the most common solid tumour in paediatrics, arising from primitive neural crest cells. The tumour suppressor protein, p53 is inactivated in NB through aberrant cytoplasmic localization, thus contributing to its tumourigenicity and multidrug resistance. Regulation of the p53 response pathway occurs through phosphorylation, however there may be dysregulation of p53 as NB contains abnormally high expression of PKCs. We investigated the role of PKC-mediated phosphorylation as a mechanism responsible for the p53 cytoplasmic sequestration in NB cell lines, [MR-32 and SHSY5Y. A

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39

Bird, Rebecca Jane. "Novel areas of crosstalk between the cyclic AMP and PKC signalling pathways." Thesis, University of Glasgow, 2010. http://theses.gla.ac.uk/2117/.

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Mediation of biological functions occurs via tightly regulated signal transduction pathways. These complex cascades often employ crosstalk with other signalling pathways to exert strict control to allow for correct cellular responses. The cyclic AMP signalling pathway is involved in a wide range of cellular processes which require tight control, including cell proliferation and differentiation, metabolism and inflammation. Protein Kinase C (PKC) signalling is also involved in the regulation of many biological functions, due to the wide range of PKC isoforms, and there is emerging evidence that

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40

Pandey, Pratima. "Role of Protein Kinase C (PKC) Isoforms in Regulation of Filopodia Dynamics." Bowling Green State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1451317928.

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41

Jama, Abdulrahman M. "Lipin1 regulates skeletal muscle differentiation through the PKC/HDAC5/MEF2c:MyoD -mediated pathway." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1533311098994136.

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42

Janoshazi, Agnès. "Study of activation process of protein kinase C (PKC) in living cells." Université Louis Pasteur (Strasbourg) (1971-2008), 2008. http://www.theses.fr/2008STR13064.

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43

Li, Chenwei. "PKC[alpha] translocation and actin remodeling in contracting A7r5 smooth muscle cells." Huntington, WV : [Marshall University Libraries], 2002. http://www.marshall.edu/etd/descript.asp?ref=62.

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Thesis (Ph. D.)--Marshall University, 2002.<br>Title from document title page. Document formatted into pages; contains xi, 136 p. with illustrations. Includes abstract. Includes bibliographical references (p. 120-136).

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44

Bull, Natalie D. "Modulation of rat retinal glutamate transporters by PKC : physiological and ischaemic outcomes /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16813.pdf.

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Bom, Vinícius Leite Pedro. "A importância da proteína fosfatase sitA na adesão, integridade da parede celular, biofilme e virulência de Aspergillus fumigatus." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17131/tde-20072016-092319/.

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Aspergillus fumigatus é um fungo patogênico oportunista capaz de infectar pacientes imunocomprometidos causando eventualmente infecções disseminadas difíceis de serem controladas e com alta taxa de mortalidade dos indivíduos infectados.. Para um melhor entendimento de como esse fungo age no hospedeiro é importante saber como as vias de sinalização que regulam esses fatores de virulência são orquestradas. Proteínas fosfatases são centrais em uma grande variedade de vias de transdução de sinal. Neste trabalho, nós caracterizamos a proteína fosfatase 2A SitA, a proteína homóloga de Sit4 em Saccha

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Kumar, Varun. "Protein Kinase C Signaling in Neurodegeneration." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1455721051.

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47

L'Ériger, Karine. "Régulation transcriptionnelle du récepteur P2X[indice inférieur 7] et son rôle dans le trafic membranaire du transporteur à glucose Glut2 dans les cellules épithéliales intestinales." Mémoire, Université de Sherbrooke, 2009. http://savoirs.usherbrooke.ca/handle/11143/4034.

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Le récepteur ionotropique P2X[indice inférieur 7] (P2X[indice inférieur 7]R) est impliqué dans divers rôles physiologiques tels la prolifération, l'apoptose, la réponse inflammatoire et le trafic membranaire dans plusieurs types cellulaires. Cependant, peu est connu quant aux rôles physiologiques du P2X[indice inférieur 7]R dans les cellules épithéliales intestinales (CEIs). Dans la littérature scientifique, le P2X[indice inférieur 7]R est connu pour activer la protéine kinase Dl (PKD1/PKC[mu]) qui est impliquée dans le transport des protéines membranaires. Comme l'un des rôles physiologiques

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48

Chihabi, Kutibh. "Protein Kinase Mzeta (PKM-ζ) Regulates Kv1.2 Dependent Cerebellar Eyeblink Classical Conditioning". ScholarWorks @ UVM, 2017. http://scholarworks.uvm.edu/graddis/719.

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Learning and memory has been a topic that has captured the attention of the scientific and public communities since the dawn of scientific discovery. Without the faculty of memory, mammals cannot experience nor function in the world; among homosapiens specifically, language, relationships, and personal identity cannot be developed (Eysenck, 2012). After all, some philosophers such as John Locke argued we are nothing but a collection of past memories in which we have developed and improved upon (Nimbalkar, 2011). Understanding the cellular mechanisms behind learning, and the subsequent formatio

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49

Saville, Stephen Paul. "Analysis of yeast proteins with immunological or sequence similarities to mammalian PKC isozymes." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/30311.

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When this project began, its principal aims were the isolation and characterisation of additional members of the yeast PKC family, which were believed to exist on the basis of biochemical data obtained in our laboratory, and others worldwide. One such gene, PKC2, was identified in our laboratory (Simon et al., 93) and a thorough functional analysis of its respective peptide product, Pkc2p was to have formed a major part of this project. In November 1994, a paper was published which cast serious doubts on the authenticity of the PKC2 gene (Levin et al., 94). In order for this study to continue,

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Schreier, Juliane [Verfasser]. "Role of PKCε in RNA granule formation and protein translation / Juliane Schreier." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/104162090X/34.

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