Relevant bibliographies by topics / PKSim

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'PKSim'

Author: Grafiati
Published: 29 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "PKSim"

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Li, Ronald C., Shekman L. Wong, and Keith K. H. Chan. "EXPANDED VERSION OF PKSIM FOR PHARMACOKINETIC SIMULATIONS OF BOTH METABOLITE AND PARENT DRUGS." American Journal of Therapeutics 4, no. 1 (1997): 16–22. http://dx.doi.org/10.1097/00045391-199701000-00004.

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Mangzira Kemung, Hefa, Loh Teng-Hern Tan, Kok-Gan Chan, et al. "Streptomyces sp. Strain MUSC 125 from Mangrove Soil in Malaysia with Anti-MRSA, Anti-Biofilm and Antioxidant Activities." Molecules 25, no. 15 (2020): 3545. http://dx.doi.org/10.3390/molecules25153545.

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There is an urgent need to search for new antibiotics to counter the growing number of antibiotic-resistant bacterial strains, one of which is methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report a Streptomyces sp. strain MUSC 125 from mangrove soil in Malaysia which was identified using 16S rRNA phylogenetic and phenotypic analysis. The methanolic extract of strain MUSC 125 showed anti-MRSA, anti-biofilm and antioxidant activities. Strain MUSC 125 was further screened for the presence of secondary metabolite biosynthetic genes. Our results indicated that both polyketide synth
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Uchiba, Mitsuhiro, Kenji Okajima, Kazunori Murakami, Hiroaki Okabe, Shosuke Okamoto, and Yoshio Okada. "Effects of Plasma Kallikrein Specific Inhibitor and Active-site Blocked Factor VIIa on the Pulmonary Vascular Injury Induced by Endotoxin in Rats." Thrombosis and Haemostasis 78, no. 04 (1997): 1209–14. http://dx.doi.org/10.1055/s-0038-1657716.

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SummaryThe acute respiratory distress syndrome (ARDS) is a serious complication of sepsis. To evaluate the role of the coagulation system in the pathogenesis of ARDS in sepsis, we examined the effects of the administration of a synthetic plasma kallikrein specific inhibitor (PKSI) and of active-site blocked factor VIIa (DEGR-VIIa) on the pulmonary vascular injury induced by E. coli endotoxin (ET) in rats. Administration of PKSI prevented the pulmonary vascular injury induced by ET as well as pulmonary histological changes in animals administered ET, but it did not affect the intravascular coag
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Ginolhac, Aurélien, Cyrille Jarrin, Benjamin Gillet, et al. "Phylogenetic Analysis of Polyketide Synthase I Domains from Soil Metagenomic Libraries Allows Selection of Promising Clones." Applied and Environmental Microbiology 70, no. 9 (2004): 5522–27. http://dx.doi.org/10.1128/aem.70.9.5522-5527.2004.

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ABSTRACT The metagenomic approach provides direct access to diverse unexplored genomes, especially from uncultivated bacteria in a given environment. This diversity can conceal many new biosynthetic pathways. Type I polyketide synthases (PKSI) are modular enzymes involved in the biosynthesis of many natural products of industrial interest. Among the PKSI domains, the ketosynthase domain (KS) was used to screen a large soil metagenomic library containing more than 100,000 clones to detect those containing PKS genes. Over 60,000 clones were screened, and 139 clones containing KS domains were det
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Świgoń, Marzena, and Karsten Weber. "Managing Knowledge and Information by Students." Journal of Information & Knowledge Management 13, no. 04 (2014): 1450030. http://dx.doi.org/10.1142/s0219649214500300.

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The concept of Personal Knowledge and Information Management (PKIM) is based, among others, on two theories: Personal Information Management (PTM) and Personal Knowledge Management (PKM), which hitherto were both subjects of separate studies. Moreover, the concept of PKIM is related to IL, which is a concept of information skills and competences of individuals — a person who manages knowledge has to be information literate. Some of the empirical studies results in the field of PKIM, started in Poland and recently continued in Germany, are presented. As the research method an unstructured quest
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Mien, Pham Thi, Dao Viet Ha, Hoang Xuan Ben, Bin Chen, Lan Liu, and Phan Minh-Thu. "Antimicrobial Activities of Sponge-Derived Microorganisms from Coastal Waters of Central Vietnam." Journal of Marine Science and Engineering 8, no. 8 (2020): 594. http://dx.doi.org/10.3390/jmse8080594.

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Bacteria associated with invertebrates are considered as good sources for biologically active compounds. Sponge-derived bacteria were screened for antimicrobial activities, the presence of the cluster genes of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs), and through a colony picking method. Crude extracts of broth cultures were tested for microbial inhibition. Eleven out of 25 isolated strains showed inhibition of at least one of eight tested indicator microorganisms. Antimicrobial activities were observed in the strains coded HM5, HM6, and HM9 with the presence o
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7

Oiwa, Kazuhiro, Osamu Matsuo, Shigeru Ueshima, et al. "Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model." Thrombosis and Haemostasis 89, no. 05 (2003): 820–25. http://dx.doi.org/10.1055/s-0037-1613467.

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SummaryWe have previously confirmed, using a rat mesenteric arteriole thrombolysis model, that thrombin inhibition induces endogenous thrombolysis in vivo. In addition, we have shown that thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the down regulation of endogenous thrombolysis. However, the mechanism of endogenous thrombolysis or spontaneous plasmin generation in vivo remains unclear.It has been shown in an in vitro system that plasma kallikrein activates pro-urokinase (pro uPA) and/or plasminogen, resulting in plasmin generation. These findings suggest that spontaneous
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Ramadoan, Sri, Pudji Muljono, and Ismail Pulungan. "PERAN PKSM DALAM MENINGKATKAN FUNGSI KELOMPOK TANI DAN PARTISIPASI MASYARAKAT DI KABUPATEN BIMA, NTB." Jurnal Penelitian Sosial dan Ekonomi Kehutanan 10, no. 3 (2013): 199–210. http://dx.doi.org/10.20886/jpsek.2013.10.3.199-210.

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Ramadoan, Sri, Pudji Muljono, and Ismail Pulungan. "PERAN PKSM DALAM MENINGKATKAN FUNGSI KELOMPOK TANI DAN PARTISIPASI MASYARAKAT DI KABUPATEN BIMA, NTB." Jurnal Penelitian Sosial dan Ekonomi Kehutanan 10, no. 3 (2013): 199–210. http://dx.doi.org/10.20886/jsek.2013.10.3.199-210.

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10

Chikita, Wulan. "ANALISIS KUALITAS BUTIR SOAL UJIAN AKHIR SEMESTER GASAL MATA PELAJARAN PKSM KELAS XI TEKNIK SEPEDA MOTOR." Jurnal Pendidikan Vokasi Otomotif 2, no. 1 (2020): 23–32. http://dx.doi.org/10.21831/jpvo.v2i1.28361.

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This research was conducted with the aim to determine the quality of items about odd Semester Final Exam Subjects of Electrical Maintenance of Class XI Motorcycle Engineering at SMK Negeri 1 Bumiratu Nuban Academic Year 2018/2019. The research method used is descriptive method with a quantitative approach. The data collection technique uses the documentation method, to obtain test questions and answer keys as well as answers to all students who take the exam. The population of the study was grade XI Motorcycle Engineering SMK Negeri 1 Bumiratu Nuban 2018/2019. The results in terms of the quest
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Dissertations / Theses on the topic "PKSim"

1

Leding, Albin. "Recommendation for first pharmacokinetic in vivo experiment design with a pharmacometric informed approach." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.

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Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. A major reason for discontinuance of a drug under development is undesired pharmacokinetic properties. Therefore, it is important to have early information of this, preferably the first time the drug is tested in animals. The first in vivo pharmacokinetic experiment is often done in mice and the only information prese
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Leding, Albin. "Optimized design recommendation for first pharmacokinetic in vivo experiments for new tuberculosis drugs using pharmacometrics modelling and simulation." Thesis, Uppsala universitet, Institutionen för farmaci, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447311.

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Tuberculosis, the leading cause of death by a single infection disease caused by bacteria, requires long treatments and the bacteria are prone to develop drug resistance. Therefore, new efficient treatment regiments needs developing, which requires new tools for drug development. A major reason for discontinuance of a drug under development is undesired pharmacokinetic properties. Therefore, it is important to have early information of this, preferably the first time the drug is tested in animals. The first in vivo pharmacokinetic experiment is often done in mice and the only information prese
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Books on the topic "PKSim"

1

Indonesia. Direktorat Kesejahteraan Anak, Keluarga dan Lanjut Usia., ed. Laporan hasil evaluasi pelaksanaan program peningkatan kesejahteraan sosial keluarga muda melalui kelompok usaha bersama keluarga muda mandiri (PKSKM melalui KUBE-KMM). Badan Kesejahteraan Sosial Nasional, Deputi Bidang Peningkatan Kesejahteraan Sosial, Direktorat Kesejahteraan Anak, Keluarga dan Lanjut Usia, 2000.

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Book chapters on the topic "PKSim"

1

Enna, S. J., and David B. Bylund. "PKSI-527." In xPharm: The Comprehensive Pharmacology Reference. Elsevier, 2007. http://dx.doi.org/10.1016/b978-008055232-3.63458-0.

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Conference papers on the topic "PKSim"

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Ahmad, Azlin, Rubiyah Yusof, and Yasue Mitsukura. "Pheromone-based Kohonen Self-Organizing Map (PKSOM) in clustering of tropical wood species: Performance and scalability." In 2015 10th Asian Control Conference (ASCC). IEEE, 2015. http://dx.doi.org/10.1109/ascc.2015.7244589.

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Journal articles
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