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Journal articles on the topic 'PKSim'

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Published: 29 June 2021

Last updated: 29 July 2025

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1

Li, Ronald C., Shekman L. Wong, and Keith K. H. Chan. "EXPANDED VERSION OF PKSIM FOR PHARMACOKINETIC SIMULATIONS OF BOTH METABOLITE AND PARENT DRUGS." American Journal of Therapeutics 4, no. 1 (1997): 16–22. http://dx.doi.org/10.1097/00045391-199701000-00004.

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Lautz, L., S. Fischer-Holzhausen, and M. Siccardi. "P05-41 Simulations of antibiotics in dairy cattle in PKSim: a case study of sulfadiazine and trimethoprim." Toxicology Letters 399 (September 2024): S147—S148. http://dx.doi.org/10.1016/j.toxlet.2024.07.376.

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Tuffaha, Haya, Laith Alshoaibi, Aya Al-tarawneh, et al. "Therapeutic drug monitoring of digoxin in Jordanian patients: Comparing saliva versus plasma." Journal of Research in Pharmacy 29, no. 4 (2024): 1485–94. https://doi.org/10.12991/jrespharm.1734554.

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Therapeutic drug monitoring (TDM) is measuring drug concentrations in plasma, serum or blood, to assure that drug concentrations can be maintained within a target range and to make sure the amount of medicine being administered is both safe and effective. TDM is essential to avoid digoxin toxicity due to its narrow therapeutic window (therapeutic levels of digoxin are 0.8-2.0 ng/mL. The toxic level is >2.4 ng/mL). TDM of digoxin is currently performed by plasma sampling, which is an invasive and painful procedure. The aim of the study is to study the pharmacokinetics of digoxin in plasma an

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Mangzira Kemung, Hefa, Loh Teng-Hern Tan, Kok-Gan Chan, et al. "Streptomyces sp. Strain MUSC 125 from Mangrove Soil in Malaysia with Anti-MRSA, Anti-Biofilm and Antioxidant Activities." Molecules 25, no. 15 (2020): 3545. http://dx.doi.org/10.3390/molecules25153545.

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There is an urgent need to search for new antibiotics to counter the growing number of antibiotic-resistant bacterial strains, one of which is methicillin-resistant Staphylococcus aureus (MRSA). Herein, we report a Streptomyces sp. strain MUSC 125 from mangrove soil in Malaysia which was identified using 16S rRNA phylogenetic and phenotypic analysis. The methanolic extract of strain MUSC 125 showed anti-MRSA, anti-biofilm and antioxidant activities. Strain MUSC 125 was further screened for the presence of secondary metabolite biosynthetic genes. Our results indicated that both polyketide synth

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Saleem, Qurat Ul Ain, Kanwal Ameen, and Murtaza Ashiq. "Personal knowledge and information management practices of life sciences research students in Pakistan." Malaysian Journal of Library & Information Science 26, no. 2 (2021): 107–23. http://dx.doi.org/10.22452/mjlis.vol26no2.6.

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The study investigated personal knowledge and information management (PKIM) practices of life sciences research students and also compared their PKIM practices based on gender and research programme. The study employed survey reserach design in which questionnaire was used to collect data. All MPhil. and PhD. life sciences research students at the University of the Punjab, Lahore, Pakistan were sampled. Altogether 196 questionnaires were distributed and 114 were successfully returned with a response rate of 58 percent. The findings are presented based on the five aspects of PKIM practices of r

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Shahzad, Khurram, Yasir Javed, Shakeel Ahmad Khan, Abid Iqbal, Imran Hussain, and M. Vaseem Jaweed. "Relationship between IT Self-Efficacy and Personal Knowledge and Information Management for Sustainable Lifelong Learning and Organizational Performance: A Systematic Review from 2000 to 2022." Sustainability 15, no. 1 (2022): 5. http://dx.doi.org/10.3390/su15010005.

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This study aims to identify the relationship between IT self-efficacy and personal knowledge and information management (PKIM) practices. It also intends to investigate trending tools and approaches being applied for PKIM for sustainable lifelong learning and organizational performance. It also reveals challenges for the development of an effective PKIM system. To meet the study’s objectives, a systematic literature review was carried out. Fifty research papers published in peer-reviewed journals were included to conduct a comprehensive systematic review. The findings of the study revealed tha

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Uchiba, Mitsuhiro, Kenji Okajima, Kazunori Murakami, Hiroaki Okabe, Shosuke Okamoto, and Yoshio Okada. "Effects of Plasma Kallikrein Specific Inhibitor and Active-site Blocked Factor VIIa on the Pulmonary Vascular Injury Induced by Endotoxin in Rats." Thrombosis and Haemostasis 78, no. 04 (1997): 1209–14. http://dx.doi.org/10.1055/s-0038-1657716.

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SummaryThe acute respiratory distress syndrome (ARDS) is a serious complication of sepsis. To evaluate the role of the coagulation system in the pathogenesis of ARDS in sepsis, we examined the effects of the administration of a synthetic plasma kallikrein specific inhibitor (PKSI) and of active-site blocked factor VIIa (DEGR-VIIa) on the pulmonary vascular injury induced by E. coli endotoxin (ET) in rats. Administration of PKSI prevented the pulmonary vascular injury induced by ET as well as pulmonary histological changes in animals administered ET, but it did not affect the intravascular coag

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Kim, Hyo-Sung, Han-Jun Kim, and Sun-Hee Do. "Early Detection of Chronic Kidney Disease Using Plasma Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Small-Breed Dogs: A Retrospective Pilot Study." Animals 14, no. 16 (2024): 2313. http://dx.doi.org/10.3390/ani14162313.

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Multiple diagnostic modalities are urgently needed to identify early-stage kidney diseases. Various molecules have been investigated; however, most studies have focused on identifying specific biomarkers in urine. Considering that assessing the symmetrical dimethylarginine (SDMA) plasma concentration is more suitable as an early diagnostic test for chronic kidney disease (CKD) in routine veterinary practice, we aimed to investigate the clinical usefulness of plasma neutrophil gelatinase-associated lipocalin (pNGAL) and plasma kidney injury molecule-1 (pKIM-1) concentrations for CKD detection i

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Ginolhac, Aurélien, Cyrille Jarrin, Benjamin Gillet, et al. "Phylogenetic Analysis of Polyketide Synthase I Domains from Soil Metagenomic Libraries Allows Selection of Promising Clones." Applied and Environmental Microbiology 70, no. 9 (2004): 5522–27. http://dx.doi.org/10.1128/aem.70.9.5522-5527.2004.

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ABSTRACT The metagenomic approach provides direct access to diverse unexplored genomes, especially from uncultivated bacteria in a given environment. This diversity can conceal many new biosynthetic pathways. Type I polyketide synthases (PKSI) are modular enzymes involved in the biosynthesis of many natural products of industrial interest. Among the PKSI domains, the ketosynthase domain (KS) was used to screen a large soil metagenomic library containing more than 100,000 clones to detect those containing PKS genes. Over 60,000 clones were screened, and 139 clones containing KS domains were det

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Mukhtar, Shahid, Ijaz Hussain Wadd, Arsalan Haider, Mohsin Zaheer, and Rashid Imran. "Anosmia in Parkinson’s Disease in Pakistan: A Matched Case – Control Study." Pakistan Journal Of Neurological Surgery 25, no. 4 (2022): 528–36. http://dx.doi.org/10.36552/pjns.v25i4.617.

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Objective: To assess olfactory dysfunction in Parkinson's disease (PD) patients in Pakistan utilizing an autochthonous smell test. Setting: Tertiary care center, single-center study. Materials and Methods: Eighty-seven non-demented patients with PD, who fulfilled Queen Square Brain Bank Criteria were enrolled at the Movement Disorder Clinic, Lahore General Hospital (LGH), Lahore. Fifty-eight controls matched by gender, age, and place of residence were enrolled among patients and visitors attending other hospital clinics. Both groups underwent olfactory testing using the Pakistani S

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Jamaludin, Rohaida, and Zetty Nurzuliana Rashed. "Penilaian Terhadap Aspek Cabaran-Cabaran yang Dihadapi Oleh Guru Semasa Menjalankan Pentaksiran Akhlak Murid." ATTARBAWIY: Malaysian Online Journal of Education 4, no. 1 (2020): 8–12. http://dx.doi.org/10.53840/attarbawiy.v4i1.22.

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Moral assessment aims to improve student morals and manners. An instrument for assessing student achievement was developed by the IKRAM Musleh Curriculum and Assessment Unit called Pentaksiran Konstruk Pelajar IKRAM Musleh (PKPIM). The PKPIM is used in a regular student behavior assessment program. A study was conducted to evaluate the process of implementing this moral assessment program using the KIPP Stufflebeam Assessment Model by focusing on the problems faced by teachers in conducting the assessment. This study uses quantitative study design using survey method. The respondents of this s

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Świgoń, Marzena, and Karsten Weber. "Managing Knowledge and Information by Students." Journal of Information & Knowledge Management 13, no. 04 (2014): 1450030. http://dx.doi.org/10.1142/s0219649214500300.

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The concept of Personal Knowledge and Information Management (PKIM) is based, among others, on two theories: Personal Information Management (PTM) and Personal Knowledge Management (PKM), which hitherto were both subjects of separate studies. Moreover, the concept of PKIM is related to IL, which is a concept of information skills and competences of individuals — a person who manages knowledge has to be information literate. Some of the empirical studies results in the field of PKIM, started in Poland and recently continued in Germany, are presented. As the research method an unstructured quest

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Mien, Pham Thi, Dao Viet Ha, Hoang Xuan Ben, Bin Chen, Lan Liu, and Phan Minh-Thu. "Antimicrobial Activities of Sponge-Derived Microorganisms from Coastal Waters of Central Vietnam." Journal of Marine Science and Engineering 8, no. 8 (2020): 594. http://dx.doi.org/10.3390/jmse8080594.

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Bacteria associated with invertebrates are considered as good sources for biologically active compounds. Sponge-derived bacteria were screened for antimicrobial activities, the presence of the cluster genes of polyketide synthases (PKSs) and non-ribosomal peptide synthetases (NRPSs), and through a colony picking method. Crude extracts of broth cultures were tested for microbial inhibition. Eleven out of 25 isolated strains showed inhibition of at least one of eight tested indicator microorganisms. Antimicrobial activities were observed in the strains coded HM5, HM6, and HM9 with the presence o

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Oiwa, Kazuhiro, Osamu Matsuo, Shigeru Ueshima, et al. "Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model." Thrombosis and Haemostasis 89, no. 05 (2003): 820–25. http://dx.doi.org/10.1055/s-0037-1613467.

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SummaryWe have previously confirmed, using a rat mesenteric arteriole thrombolysis model, that thrombin inhibition induces endogenous thrombolysis in vivo. In addition, we have shown that thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the down regulation of endogenous thrombolysis. However, the mechanism of endogenous thrombolysis or spontaneous plasmin generation in vivo remains unclear.It has been shown in an in vitro system that plasma kallikrein activates pro-urokinase (pro uPA) and/or plasminogen, resulting in plasmin generation. These findings suggest that spontaneous

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Fu, Ying. "Research on PKIM Energy Construction Engineering Software System Based on Building BIM Technology." Wireless Communications and Mobile Computing 2022 (April 26, 2022): 1–7. http://dx.doi.org/10.1155/2022/2546708.

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In order to study building BIM technology PKIM energy building engineering software system, firstly, the building collaborative platform based on BIM technology and PKPM professional software BIM technology application is constructed. Then, it introduces that PKPM connects all aspects of construction projects through the core 3D data model and takes the lead in realizing the BIM concept of information datalization, data modeling, and model generalization, thus realizing the full utilization of building model data in the whole life cycle. Finally, this paper introduces the seismic analysis meth

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Fu, Ying. "Research on PKIM Energy Construction Engineering Software System Based on Building BIM Technology." Wireless Communications and Mobile Computing 2022 (April 26, 2022): 1–7. http://dx.doi.org/10.1155/2022/2546708.

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In order to study building BIM technology PKIM energy building engineering software system, firstly, the building collaborative platform based on BIM technology and PKPM professional software BIM technology application is constructed. Then, it introduces that PKPM connects all aspects of construction projects through the core 3D data model and takes the lead in realizing the BIM concept of information datalization, data modeling, and model generalization, thus realizing the full utilization of building model data in the whole life cycle. Finally, this paper introduces the seismic analysis meth

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Ariyanto, P., A. A. B. Al-Hakim, B. Pranata, Daryono, and S. P. Adi. "Identification of Moho Discontinuity Depth and Subduction Slab in Bengkulu and South Sumatra Region using Receiver Function Method: A Preliminary Result." IOP Conference Series: Earth and Environmental Science 1288, no. 1 (2023): 012012. http://dx.doi.org/10.1088/1755-1315/1288/1/012012.

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Abstract Bengkulu and South Sumatra regions are areas with high seismic activity due to faults and subduction zones. This study aims to analyze the depth of the Moho discontinuity layer and subduction slab under 4 BMKG seismic stations that form a perpendicular line of trench in the Bengkulu and South Sumatra areas. The distribution of stations used are Enggano Station (EGSI) in the front arc islands, Manna Station (MNAI) in the front arc basin, Pagar Alam Station (PKSI) in the volcanic-arc zone, and Lahat Station (LHSI) in the proto-volcanic zone. We selected teleseismic earthquake data with

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Ramadoan, Sri, Pudji Muljono, and Ismail Pulungan. "PERAN PKSM DALAM MENINGKATKAN FUNGSI KELOMPOK TANI DAN PARTISIPASI MASYARAKAT DI KABUPATEN BIMA, NTB." Jurnal Penelitian Sosial dan Ekonomi Kehutanan 10, no. 3 (2013): 199–210. http://dx.doi.org/10.20886/jpsek.2013.10.3.199-210.

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Ramadoan, Sri, Pudji Muljono, and Ismail Pulungan. "PERAN PKSM DALAM MENINGKATKAN FUNGSI KELOMPOK TANI DAN PARTISIPASI MASYARAKAT DI KABUPATEN BIMA, NTB." Jurnal Penelitian Sosial dan Ekonomi Kehutanan 10, no. 3 (2013): 199–210. http://dx.doi.org/10.20886/jsek.2013.10.3.199-210.

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Mobile Computing, Wireless Communications and. "Retracted: Research on PKIM Energy Construction Engineering Software System Based on Building BIM Technology." Wireless Communications and Mobile Computing 2023 (December 13, 2023): 1. http://dx.doi.org/10.1155/2023/9756746.

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21

Areola, Phd HSG, Eunice Mareth Querol, Irvin Perono, and Joan Camille Ilagan. "The Relationship of Sustainable Buying Behavior Dimensions Among the Gen Z: Modeling the Impact of Psychological Factors." Journal of Sustainable Community Development (JSCD) 4, no. 1 (2022): 30–39. http://dx.doi.org/10.32924/jscd.v4i1.66.

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Sustainable consumption has continuously become a trend in the behavior of consumers over the recent decades due to drastic changes in technological advancement, economic development, and population growth on a global scale. This research aimed to establish the relationship among the dimensions of sustainable purchase behavior of the Gen Z living in Metro Manila, Philippines. Multiple regression analysis was used to establish the psychological factors of Generation Z's overall sustainable purchase behavior. Findings revealed that the Perceived Knowledge About Sustainability Issues (PKSI), Atti

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Chikita, Wulan. "ANALISIS KUALITAS BUTIR SOAL UJIAN AKHIR SEMESTER GASAL MATA PELAJARAN PKSM KELAS XI TEKNIK SEPEDA MOTOR." Jurnal Pendidikan Vokasi Otomotif 2, no. 1 (2020): 23–32. http://dx.doi.org/10.21831/jpvo.v2i1.28361.

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This research was conducted with the aim to determine the quality of items about odd Semester Final Exam Subjects of Electrical Maintenance of Class XI Motorcycle Engineering at SMK Negeri 1 Bumiratu Nuban Academic Year 2018/2019. The research method used is descriptive method with a quantitative approach. The data collection technique uses the documentation method, to obtain test questions and answer keys as well as answers to all students who take the exam. The population of the study was grade XI Motorcycle Engineering SMK Negeri 1 Bumiratu Nuban 2018/2019. The results in terms of the quest

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Grandy Sihotang, Rindu Antika, Talitha Zahira, and Nurul Hadawiyah Harahap. "Optimisme Mahasiswa Kimia Penulisan Teks Akademik di Era AI, Peluang dan Tantangan Pendidikan Sains Indonesia." JURNAL PENDIDIKAN DAN ILMU SOSIAL (JUPENDIS) 3, no. 2 (2025): 237–50. https://doi.org/10.54066/jupendis.v3i2.3167.

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This study explores the optimism of Chemistry students at Medan State University towards the use of artificial intelligence (AI) in writing academic texts. PKSM 23B students were interviewed using a qualitative approach to conduct this study. The results showed that most students saw AI as a great tool to trouble academic texts, as well as the challenges and opportunities of using AI. However, there were concerns about the possibility of engaging in plagiarism and reducing critical thinking skills. The limitations of AI infrastructure and information quality are additional problems. This study

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Amir, Ahmad Nabil. "Dr Siddiq Fadzil dan Derap Perjuangannya." Borneo International Journal of Islamic Studies 2, no. 1 (2019): 101–11. http://dx.doi.org/10.21093/bijis.v2i1.1631.

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Kertas ini menelaah buku Melayu dan Islam: Martabat Umat dan Daulat Rakyat karya Dr Siddiq Fadzil. Setelah diluncurkan pada 25 Jun 2012 di Hotel De Palma, Ampang, buku Melayu dan Islam: Martabat Umat dan Daulat Rakyat karya Dr Siddiq Fadzil terus diangkat dan “siap ditanggapi” oleh khalayak pembaca dan intelek. Dr Siddiq lahir di kalangan pemikir dan kelompok pembaharu di tanah air; dan merupakan aktivis dan pemimpin Islam yang besar yang menonjol dalam kegiatan intelek dan budaya yang luas. Beliau merupakan penggerak penting gerakan PKPIM (Persatuan Kebangsaan Pelajar Islam Malaysia), ABIM (A

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Yusof, Rubiyah, Azlin Ahmad, Nor Saradatul Akmar Zulkifli, and Mohd Najib Ismail. "An Improved Pheromone-Based Kohonen Self- Organising Map in Clustering and Visualising Balanced and Imbalanced Datasets." Journal of Information and Communication Technology 20, No.4 (2020): 651–76. http://dx.doi.org/10.32890/jict2021.20.4.8.

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The data distribution issue remains an unsolved clustering problem in data mining, especially in dealing with imbalanced datasets. The Kohonen Self-Organising Map (KSOM) is one of the well-known clustering algorithms that can solve various problems without a pre-defined number of clusters. However, similar to other clustering algorithms, this algorithm requires sufficient data for its unsupervised learning process. The inadequate amount of class label data in a dataset significantly affects the clustering learning process, leading to inefficient and unreliable results. Numerous research have b

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El-Haroun, H., D. L. Clarke, K. Deacon та ін. "IL-1β, BK, and TGF-β1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA". American Journal of Physiology-Lung Cellular and Molecular Physiology 294, № 3 (2008): L553—L562. http://dx.doi.org/10.1152/ajplung.00044.2006.

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We have previously shown that interleukin (IL)-1β, transforming growth factor (TGF)-β1, or bradykinin (BK) impair cAMP generation in response to prostacyclin analogs in human pulmonary artery smooth muscle (PASM), suggesting that inflammation can impair the effects of prostacyclin analogs on PASM in pulmonary hypertension. Here we explored the biochemical mechanisms involved. We found that IL-1β, BK, and TGF-β1 reduced adenylyl cyclase isoform 1, 2, and 4 mRNA, increased Gαi protein levels, and reduced prostacyclin receptor (IP receptor) mRNA expression. In contrast, Gαs protein levels were un

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Ayşe, ŞAHIN, and KURUDIREK Fatma. "Development of a Parental Knowledge Scale for Inhalation Practices." Gevher Nesibe Journal of Medical & Health Sciences 8, Özel Sayı (2023): 808–18. https://doi.org/10.5281/zenodo.8404236.

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<strong>Objective:</strong> Develop a parental knowledge scale for inhalation practices and conduct a validity-reliability study. <strong>Methods: </strong>A methodological study design was chosen. The research was carried out between February 2020 and June 2022 in the pediatric services of training-research hospitals in Erzurum. The study population consisted of parents with children aged 0-6 who received inhalation therapy in the pediatric services of the hospitals. The number of items on the scale was reached 9 times, and the sample of the study consisted of 390 parents. Frequency distribut

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Adams, Gregory N., Gretchen A. LaRusch, Evi Stavrou, et al. "Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis." Blood 117, no. 14 (2011): 3929–37. http://dx.doi.org/10.1182/blood-2010-11-318527.

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Abstract Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCPgt/gt mice reveals expression in kidney and vasculature. Invasive telemetric monitorings show that PRCPgt/gt mice have significantly elevated blood pressure. PRCPgt/gt mice demonstrate shorter carotid artery occlusion times in 2 models, and their plasmas have increased thrombin generation times. Pharmacologic inhibition of PRCP with Z-Pro-Prolinal or pl

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Guan, Limei, Hongxiu Wang, Junhui Chen, et al. "Isolation and Identification of Culturable Bacteria from South China Seawater and Preliminary Screening of Marine Biocontrol Bacteria." Microorganisms 11, no. 12 (2023): 2933. http://dx.doi.org/10.3390/microorganisms11122933.

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Marine microorganisms have evolved special metabolic pathways to produce numerous bioactive substances with novel structures and unique functions. This study analyzed the diversity of culturable bacteria in marine water samples from the South China Sea and screened the isolated bacteria with pathogenic fungi. A total of 200 culturable strains of 72 different bacteria were obtained from 56 water samples from the South China Sea. They belonged to three phyla and four classes, namely Gammaproteobacteria, Alphaproteobacteria, Bacilli and Actinomycetia. Bacilli was the dominant class, comprising up

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Tomoo, K., K. Satoh, Y. Tsuda, et al. "Binding Diversity of a Noncovalent-Type Low-Molecular-Weight Serine Protease Inhibitor and Function of a Catalytic Water Molecule: X-Ray Crystal Structure of PKSI-527-Inhibited Trypsin." Journal of Biochemistry 129, no. 3 (2001): 455–60. http://dx.doi.org/10.1093/oxfordjournals.jbchem.a002877.

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FUKUMIZU, Atsuko, Yoko TSUDA, Keiko WANAKA, et al. "Amino Acids and Peptides. LIII. Synthesis and Biological Activities of Some Pseudo-Peptide Analogs of PKSI-527, a Plasma Kallikrein Selective Inhibitor. The Importance of the Peptide Backbone." CHEMICAL & PHARMACEUTICAL BULLETIN 47, no. 8 (1999): 1141–44. http://dx.doi.org/10.1248/cpb.47.1141.

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Gauthier-Rouvière, C., M. Vandromme, N. Lautredou, et al. "The serum response factor nuclear localization signal: general implications for cyclic AMP-dependent protein kinase activity in control of nuclear translocation." Molecular and Cellular Biology 15, no. 1 (1995): 433–44. http://dx.doi.org/10.1128/mcb.15.1.433.

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We have identified a basic sequence in the N-terminal region of the 67-kDa serum response factor (p67SRF or SRF) responsible for its nuclear localization. A peptide containing this nuclear localization signal (NLS) translocates rabbit immunoglobulin G (IgG) into the nucleus as efficiently as a peptide encoding the simian virus 40 NLS. This effect is abolished by substituting any two of the four basic residues in this NLS. Overexpression of a modified form of SRF in which these basic residues have been mutated confirms the absolute requirement for this sequence, and not the other basic amino ac

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Wang, Liuqing, Nan Jiang, Duo Wang, and Meng Wang. "Effects of Essential Oil Citral on the Growth, Mycotoxin Biosynthesis and Transcriptomic Profile of Alternaria alternata." Toxins 11, no. 10 (2019): 553. http://dx.doi.org/10.3390/toxins11100553.

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Alternaria alternata is a critical phytopathogen that causes foodborne spoilage and produces a polyketide mycotoxin, alternariol (AOH), and its derivative, alternariol monomethyl ether (AME). In this study, the inhibitory effects of the essential oil citral on the fungal growth and mycotoxin production of A. alternata were evaluated. Our findings indicated that 0.25 μL/mL (222.5 μg/mL) of citral completely suppressed mycelial growth as the minimum inhibitory concentration (MIC). Moreover, the 1/2MIC of citral could inhibit more than 97% of the mycotoxin amount. Transcriptomic profiling was per

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इंगळे, उमेश भाऊराव. ""जागतिक महिला सशक्तिकरण मे समाज कि भूमिका"". International Journal of Advance and Applied Research 5, № 35 (2024): 78–81. https://doi.org/10.5281/zenodo.13856433.

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<strong>lkjka’k %&</strong>                 vkt fo’o ds lHkh {ks= esa efgyk vxzslj gS tSls dYiuk pkoyk rFkk lqfurk foY;e us varjkG {ks= esa egRRoiw.kZ dk;Z fd;k gSA fdj.k csnh] fuyk lR;ukjk;.k rFkk vk;ih,l nqxkZ’kDrh tSlh efgykavksus iksfyl iz’kklu {ks= iknkØkar fd;k gSA lqjs[kk ;kno ds #i esa jsYos dks ifgyh efgyk eksVjoqeu fey xbZA ih-Vh-m"kk ls [ksy fd izxrh fd lq#okr gksbZ tks d.kZe eYys’ojh] esjh dkse] vatwckch tkWt] lk;uk usgoky] lkfu;k fe>kZ] ferkyh jkt] izkFkZuk Bksacj

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Adams, Gregory, Gretchen LaRusch, Evi Stavrou, et al. "Prolylcarboxypeptidase Deficiency Is a Risk Factor for Arterial Thrombosis and Hypertension." Blood 116, no. 21 (2010): 651. http://dx.doi.org/10.1182/blood.v116.21.651.651.

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Abstract Abstract 651 Background. Prolylcarboxypeptidase (PRCP), an S28 serine protease, degrades bradykinin, angiotensin II, and alpha melanocyte stimulating hormone and activates prekallikrein to plasma kallikrein (Blood 103:4554, 2004). In GWAS, it has been recognized as a risk factor for metabolic syndrome, hypertension, and pre-eclampsia. We postulated that PRCP murine hypomorphs (PRCPgt/gt) have a cardiovascular phenotype. Methods and Results. PRCP is mostly found in kidney in proximal tubules. In arteries, it is found both on endothelium and in media. A gene-trap murine hypomorph was cr

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Zaliani, A., C. Mueller, and M. Rarey. "Prediction of kinase inhibitors cross-reaction on the basis of kinase ATP cavity similarities: a study using PKSIM protein similarity score." Chemistry Central Journal 2, S1 (2008). http://dx.doi.org/10.1186/1752-153x-2-s1-p19.

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Xu, Wenxin, Valerie Gaborieau, Samuel M. Niman, et al. "Plasma Kidney Injury Molecule-1 for Preoperative Prediction of Renal Cell Carcinoma Versus Benign Renal Masses, and Association With Clinical Outcomes." Journal of Clinical Oncology, May 3, 2024. http://dx.doi.org/10.1200/jco.23.00699.

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PURPOSE Both clear cell and papillary renal cell carcinomas (RCCs) overexpress kidney injury molecule-1 (KIM-1). We investigated whether plasma KIM-1 (pKIM-1) may be a useful risk stratification tool among patients with suspicious renal masses. METHODS Prenephrectomy pKIM-1 was measured in two independent cohorts of patients with renal masses. Cohort 1, from the prospective K2 trial, included 162 patients found to have clear cell RCC (cases) and 162 patients with benign renal masses (controls). Cohort 2 included 247 patients with small (cT1a) renal masses from an academic biorepository, of who

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Kazeem, K. Adewole. "Development of Palm Kernel Shell Lightweight Masonry Mortar." April 1, 2017. https://doi.org/10.5281/zenodo.1130537.

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There need to construct building walls with lightweight masonry bricks/blocks and mortar to reduce the weight and cost of cooling/heating of buildings in hot/cold climates is growing partly due to legislations on energy use and global warming. In this paper, the development of Palm Kernel Shell masonry mortar (PKSMM) prepared with Portland cement and crushed PKS fine aggregate (an agricultural waste) is demonstrated. We show that PKSMM can be used as a lightweight mortar for the construction of lightweight masonry walls with good thermal insulation efficiency than the natural river sand common

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Chu Thanh Bình. "ĐẶC ĐIỂM SINH HỌC CỦA CHỦNG XẠ KHUẨN Streptomyces MIP_SN16 PHÂN LẬP TỪ ĐẤT VÙNG RỄ CÂY NGHỆ (Curcuma longa L.) KHU VỰC TỈNH HƯNG YÊN". Tạp chí Y học Quân sự, 8 жовтня 2024. http://dx.doi.org/10.59459/1859-1655/jmm.454.

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Mục tiêu: Mô tả đặc điểm sinh học của chủng xạ khuẩn Streptomyces MIP_SN16 bao gồm đặc điểm hình thái, màu sắc khuẩn lạc, cấu trúc sinh bào tử, hoạt tính đối kháng với vi khuẩn Gram dương Bacillus cereus và Gram âm Escherichia coli, phân tích sự có mặt của các cụm gen sinh tổng hợp chất kháng sinh. Đối tượng và phương pháp: Chủng xạ khuẩn Streptomyces MIP_SN16 được hoạt hóa từ bộ sưu tập chủng vi sinh vật tại Khoa Vi sinh vật - Viện Y học Dự phòng Quân đội. Đặc điểm hình thái, màu sắc khuẩn lạc, cấu trúc sinh bào tử được mô tả theo phương pháp của Tresner (1963); Hoạt tính đối kháng với vi khu

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Llewellyn, Theo, Reuben W. Nowell, Andre Aptroot, et al. "Data files for Llewellyn et al. 2023 'Metagenomics shines light on the evolution of 'sunscreen' pigment metabolism in the Teloschistales (lichen-forming Ascomycota) doi:." August 22, 2022. https://doi.org/10.5281/zenodo.7015195.

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Anthraquinone_aa_sequences_and_tree -  FASTA files containing aligned amino acid and nucleotide sequences for putative anthraquinone PKSI genes from 45 whole genome Lecanoromycetes lichen dataset used to generate gene tree. Also contain ML gene tree generated by RAxML-ng Orthogroup_trimmed_alignments - FASTA files containing trimAl trimmed alignments for single copy orthologues used to reconstruct ML and coalescent-based phylogenomic trees. Phylogenetic_trees - gene and species trees used for whole genome phylogenetic analysis HMM_seed_alignment_and_tree - CLUSTAL file containing multiple

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Ihsan, Halus Satriawan, and Rahmat Abbas. "Analisis Potensi dan Stakeholder Ekowisata Danau Lut Atas Kabupaten Bener Meriah Provinsi Aceh." Jurnal Serambi Engineering 9, no. 1 (2024). http://dx.doi.org/10.32672/jse.v9i1.661.

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Ecotourism is a travel industry that adopts environmentally friendly practices, protecting natural and cultural heritage. The research objective is to analyze the potential and stakeholders of Lut Atas lake ecotourism. Ecotourism potential using Natural Tourism Operations and Attractions Analysis (ODTWA) guidelines as well as stakeholder descriptions through the Stakeholder Grid. The results of the research show that ecotourism in the Upper Lut Lake area has tourist objects and attractions that are worth developing, although it has several obstacles and constraints. ODTWA that have the potenti

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Cara, Magdalena, Mirela Toska, Dajana Frasheri, Riccardo Baroncelli, and Simona Marianna Sanzani. "Alternaria species causing pomegranate and citrus fruit rots in Albania." Journal of Plant Diseases and Protection, June 13, 2022. http://dx.doi.org/10.1007/s41348-022-00630-7.

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AbstractThe fungal genus Alternaria is a relevant pathogen for several commodities including citrus and pomegranate fruits. On citrus, it mainly causes brown spots on fruits and leaves, whereas on pomegranate, it mostly causes a fruit heart rot. In the present study the presence of Alternaria rots on citrus and pomegranate fruits cultivated in Albania was assessed. Representative fruits were collected from different regions. Nineteen and thirteen Alternaria spp. isolates were obtained from pomegranate and citrus samples, respectively. The isolates were identified at species and morphotype leve

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Nair, Asha V., Alice Robson, Thomas D. Ackrill та ін. "Structure and mechanism of a dehydratase/decarboxylase enzyme couple involved in polyketide β-methyl branch incorporation". Scientific Reports 10, № 1 (2020). http://dx.doi.org/10.1038/s41598-020-71850-w.

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Abstract Complex polyketides of bacterial origin are biosynthesised by giant assembly-line like megaenzymes of the type 1 modular polyketide synthase (PKS) class. The trans-AT family of modular PKSs, whose biosynthetic frameworks diverge significantly from those of the archetypal cis-AT type systems represent a new paradigm in natural product enzymology. One of the most distinctive enzymatic features common to trans-AT PKSs is their ability to introduce methyl groups at positions β to the thiol ester in the growing polyketide chain. This activity is achieved through the action of a five protei

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Chu Thanh Bình. "HOẠT TÍNH ĐỐI KHÁNG VỚI VI SINH VẬT GÂY BỆNH CHO NGƯỜI CỦA CHỦNG XẠ KHUẨN Streptomyces MIP_GN36 PHÂN LẬP TỪ ĐẤT VÙNG RỄ CÂY GỪNG". Tạp chí Y học Quân sự, 26 квітня 2024, 6. http://dx.doi.org/10.59459/1859-1655/jmm.400.

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Mục tiêu: Sàng lọc chủng xạ khuẩn từ đất vùng rễ cây Gừng (Zingiber officinale) nhằm tìm kiếm các chất có hoạt tính kháng vi khuẩn, kháng nấm và hoạt tính sinh học tiềm năng, làm cơ sở cho những nghiên cứu tiếp theo. Đối tượng, phương pháp: Thử nghiệm hoạt tính đối kháng của 8 chủng xạ khuẩn (Streptomyces MIP_GN34, GN35, GN36, GN37, GN38, GN39, GN40, GN41) phân lập từ đất vùng rễ cây Gừng (khu vực huyện Khoái Châu, tỉnh Hưng Yên) với 2 chủng vi sinh vật gây bệnh (Bacillus cereus ATCC11778 và Candida albican ATCC12031) bằng phương pháp khuếch tán đĩa thạch. Kết quả: Streptomyces MIP_GN36 có hoạ

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Wulandari, Christine, Hari Kaskoyo, Samsul Bakri, Yudi Safril Ariza, Cindy Yoeland Violita, and Puspa Hartati. "The Importance of Community Empowerment through Strengthening Farmer Groups in the Forest Management Unit (KPH) Way Terusan Central Lampung, Lampung Province Indonesia." Asian Journal of Research in Agriculture and Forestry, February 7, 2023, 28–37. http://dx.doi.org/10.9734/ajraf/2023/v9i1194.

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This study aims to examine and determine the implementation of activities in strengthening the Forest Farmer Group (KTH) in Way Terusan Forest Management Unit (KPH) of Central Lampung, Lampung Province. This study is conducted because apparently only about 87% of 42 forest farmer group still actively run their program. The research was conducted on August - September 2022 using direct observation research method by collecting primary and secondary data. There were 42 respondents that represented the 42 KTH as a research data. The data is analyzed by using descriptive approach that includes bot

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Ushakova, L., O. Panzyha, N. Ulanovych, and A. Popsuy. "IMPLEMENTATION OF THE OBJECTIVES OF THE PRACTICAL COURSE OF THE SECOND FOREIGN LANGUAGE BY ZOOM." January 26, 2022. https://doi.org/10.5281/zenodo.5971963.

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The article considers the sense of distance learning and analyzes the use of possible web resources for online classes in various disciplines. Accepted attention to the specific features of the subject «foreign language». <strong>The purpose</strong> of the article is to identify and analyze the possibilities of using the Zoom service to achieve the goals of foreign language learning in the practical course of the second foreign language of students of the Faculty of Philology. The main tools of the Zoom service and the possibilities of their use in foreign language classes are con

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