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Relevant bibliographies by topics / Placenta, OPG, Pregnancy, Multiple Sclerosis

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Journal articles
Dissertations / Theses

Academic literature on the topic 'Placenta, OPG, Pregnancy, Multiple Sclerosis'

Author: Grafiati

Published: 14 March 2023

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Journal articles on the topic "Placenta, OPG, Pregnancy, Multiple Sclerosis"

1

Passaponti, Sofia, Leonardo Ermini, Giulia Acconci, et al. "Rank-Rankl-Opg Axis in Multiple Sclerosis: The Contribution of Placenta." Cells 11, no. 8 (2022): 1357. http://dx.doi.org/10.3390/cells11081357.

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Women with multiple sclerosis (MS) can safely become pregnant and give birth, with no side effects or impediments. Pregnancy is generally accepted as a period of well-being in which relapses have a softer evolution, particularly in the third trimester. Herein, we hypothesized that the placenta, via its “secretome”, could contribute to the recognized beneficial effects of pregnancy on MS activity. We focused on a well-known receptor/ligand/decoy receptor system, such as the one composed by the receptor activator of nuclear factor-kB (RANK), its ligand (RANKL), and the decoy receptor osteoproteg

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2

Andersen, Johanna Balslev, Tine Iskov Kopp, Finn Sellebjerg, and Melinda Magyari. "Pregnancy-Related and Perinatal Outcomes in Women With Multiple Sclerosis." Neurology: Clinical Practice 11, no. 4 (2021): 280–90. http://dx.doi.org/10.1212/cpj.0000000000001035.

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ObjectiveTo investigate differences in pregnancy-related and perinatal outcomes in women with multiple sclerosis (MS) compared with the general population.MethodsWe conducted a cross-sectional study including pregnancies from January 1, 1997, to December 31, 2016, to women registered in the Danish Multiple Sclerosis Registry (the study cohort). Pregnancy-related and perinatal outcomes were compared with a randomly selected subcohort of pregnancies from the general population (the comparison cohort) using logistic regression adjusted for possible confounders.ResultsIn total, 2,930 pregnancies w

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3

Galati, Alexandra, Thomas McElrath, and Riley Bove. "Use of B-Cell–Depleting Therapy in Women of Childbearing Potential With Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder." Neurology: Clinical Practice 12, no. 2 (2022): 154–63. http://dx.doi.org/10.1212/cpj.0000000000001147.

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Purpose of ReviewThere is considerable heterogeneity in the use of B-cell depletion in women of childbearing age, likely driven at least in part by the discrepancy between the product labels and what is known about the physiology of IgG1, including breastmilk and placental transfer.Recent FindingsWe provide practical considerations on the use of this medication class in women of childbearing potential. We discuss prepregnancy planning including vaccinations, safety of B-cell depletion during pregnancy, and postpartum considerations including breastfeeding.SummaryB-cell–depleting monoclonal ant

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4

Martire, Serena, Francesca Montarolo, Michela Spadaro, et al. "A First Phenotypic and Functional Characterization of Placental Extracellular Vesicles from Women with Multiple Sclerosis." International Journal of Molecular Sciences 22, no. 6 (2021): 2875. http://dx.doi.org/10.3390/ijms22062875.

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Pregnancy is a unique situation of physiological immunomodulation, as well as a strong Multiple Sclerosis (MS) disease modulator whose mechanisms are still unclear. Both maternal (decidua) and fetal (trophoblast) placental cells secrete extracellular vesicles (EVs), which are known to mediate cellular communication and modulate the maternal immune response. Their contribution to the MS disease course during pregnancy, however, is unexplored. Here, we provide a first phenotypic and functional characterization of EVs isolated from cultures of term placenta samples of women with MS, differentiati

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5

Tovo, Pier-Angelo, Luca Marozio, Giancarlo Abbona, et al. "Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis." Viruses 15, no. 3 (2023): 710. http://dx.doi.org/10.3390/v15030710.

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Accumulating evidence highlights the pathogenetic role of human endogenous retroviruses (HERVs) in eliciting and maintaining multiple sclerosis (MS). Epigenetic mechanisms, such as those regulated by TRIM 28 and SETDB1, are implicated in HERV activation and in neuroinflammatory disorders, including MS. Pregnancy markedly improves the course of MS, but no study explored the expressions of HERVs and of TRIM28 and SETDB1 during gestation. Using a polymerase chain reaction real-time Taqman amplification assay, we assessed and compared the transcriptional levels of pol genes of HERV-H, HERV-K, HERV

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Dissertations / Theses on the topic "Placenta, OPG, Pregnancy, Multiple Sclerosis"

1

Passaponti, Sofia. "The role of the placenta on the RANK/RANKL/OPG axis: a glance at Multiple Sclerosis." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1202797.

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La placenta è un organo di fondamentale importanza per il successo della gravidanza; è coinvolta nel dialogo tra la madre e il feto, non solo fornendo ossigeno e nutrienti essenziali al bambino in via di sviluppo, ma ha anche un ruolo attivo nella sintesi e nel rilascio di fattori nella circolazione materna e fetale. La gravidanza è anche nota per sopprimere la risposta infiammatoria in alcune malattie autoimmuni, come ad esempio la sclerosi multipla. Questi effetti benefici della gravidanza sono sempre stati ricondotti ai cambiamenti che il sistema immunitario materno mette in atto per accett

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