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Dissertations / Theses on the topic 'Placenta – Physiologie'

Author: Grafiati

Published: 29 March 2025

Last updated: 31 July 2025

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1

Ayache, Mohammad. "Application des réseaux de neurones à la classification automatisée des grades placentaires." Tours, 2007. http://www.theses.fr/2007TOUR3315.

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Le placenta est un organe provisoire joignant la mère et le fœtus qui transfère l’oxygène et des nutriments de la mère au fœtus et permet l’évacuation de l’anhydride carbonique et des produits du métabolisme du fœtus. Le but de notre travail était d’étudier la fonction de transfert des tissus placentaires selon son développement en se basant sur les images ultrasonores. Nous avons développé au cours de ce travail une nouvelle approche de la classification du développement placentaire en ultrasons par des techniques de traitement d’images avancées basée sur une représentation par réseau neurona

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2

Routhier, Catherine. "Étude de la voie des polyols dans le placenta en prééclampsie." Thesis, Université Laval, 2014. http://www.theses.ulaval.ca/2014/30339/30339.pdf.

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La prééclampsie (PE) est une pathologie obstétricale complexe associée à un défaut de placentation. Selon la littérature, le placenta anormalement développé libèrerait des facteurs qui induiraient une dysfonction endothéliale maternelle. Nous avons émis comme hypothèse qu’une accumulation de sorbitol, un sucre hyperosmotique produit par la voie des polyols, pourrait induire la libération par le placenta de sFlt-1, un facteur anti-angiogénique antagoniste du VEGF en PE. Nous avons comparé les niveaux d’expression d’ARNm et de protéines de AKR1B1 et SORD, les deux enzymes impliquées dans la voie

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3

Beauchemin, David. "Étude de la synthèse des prostanoïdes vasoactifs et de leurs récepteurs dans le placenta en prééclampsie." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/27970/27970.pdf.

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4

Le, Duc Kévin. "Physiologie des échanges gazeux et de l'hémodynamique transplacentaire lors d'une réanimation à cordon intact : modèle expérimental d'agneau porteur de hernie diaphragmatique." Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS079.

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La naissance est une période à risque qui met en jeux de multiples mécanismes qui permettent une transition de la vie fœtale et la vie extra-utérine. Chaque année, dans les conséquences d'une mauvaise adaptation à la vie extra-utérine et la persistance de résistances vasculaires pulmonaires trop élevées, 1 million de nouveau-né décède dans les 24 premières heures de vie. Dix pourcents des nouveau-nés requièrent une assistance médicale en salle de naissance. Le clampage du cordon ombilical retardé entre 60 et 180 secondes après la naissance est désormais recommandé pour toutes les situations où

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5

Bartho, Lucy A. "Mitochondrial Alterations Through Gestation and in Placental Pathologies." Thesis, Griffith University, 2021. http://hdl.handle.net/10072/411262.

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The placenta is a transient organ, essential for the growth and development of the fetus throughout pregnancy. This temporary organ brings maternal and fetal blood circulation into close proximity, which allows for the exchange of oxygen, carbon dioxide, waste, and other essential nutrients. Despite constant influences by internal and external factors, the human placenta has a defined life span of approximately 280 days. From conception, through to term, the placenta undergoes chronological aging, which is regulated by a range of cellular processes. Advanced placental aging and cellular senesc

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6

Corbel, Tanguy. "Mécanismes toxicocinétiques impliqués dans l'exposition foetale au Bisphénol A." Thesis, Toulouse, INSA, 2013. http://www.theses.fr/2013ISAT0034/document.

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Le Bisphénol A (BPA) est un perturbateur endocrinien dont les effets développementaux observés chez les rongeurs soulèvent la question du risque pour la santé humaine relatif à une exposition fœtale au BPA. L’objectif de cette thèse est de déterminer les mécanismes toxicocinétiques impliqués dans l’exposition fœtale au BPA. La caractérisation in vivo dans un modèle intégratif ovin des expositions maternelles et fœtales au BPA et à ses métabolites ont permis d’identifier le transfert placentaire et le métabolisme fœto-placentaire comme les déterminants majeurs de l’exposition fœtale au BPA. Le

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7

Rao, M. Rekha. "Functional Differentiation Of The Human Placenta : Insights From The Expression Of Two Developmentally - Regulated Genes." Thesis, Indian Institute of Science, 2000. https://etd.iisc.ac.in/handle/2005/177.

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Placenta is a transient association of the fetal and maternal tissues, that develops during pregnancy, in most viviparous animals. The evolution of placenta ensured the development of the fetus inside the womb of the mother, providing a protected environment for the development of the fetus, and preventing the loss of progeny due to unfavorable environmental conditions. Because it is strategically poised at the maternal and fetal interface, the placenta is ideally suited to carry out alimentary, respiratory and excretory functions for the developing fetus. In addition, it serves as an immunolo

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8

Rao, M. Rekha. "Functional Differentiation Of The Human Placenta : Insights From The Expression Of Two Developmentally - Regulated Genes." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/177.

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Placenta is a transient association of the fetal and maternal tissues, that develops during pregnancy, in most viviparous animals. The evolution of placenta ensured the development of the fetus inside the womb of the mother, providing a protected environment for the development of the fetus, and preventing the loss of progeny due to unfavorable environmental conditions. Because it is strategically poised at the maternal and fetal interface, the placenta is ideally suited to carry out alimentary, respiratory and excretory functions for the developing fetus. In addition, it serves as an immunolo

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9

Griffith, Oliver William. "Mechanisms of placental evolution: the genetics and physiology of pregnancy in lizards." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/13600.

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The placenta is a unique example of a complex organ that has evolved independently more than 115 times in amniotes (birds, reptiles, and mammals). Placentae exchange materials including respiratory gasses, nutrients, and hormones, between the mother and embryo. I aimed to identify the physiological and ecological factors that contribute to the evolution of placentation in vertebrates, focusing on the genetic mechanisms underpinning the evolution of placental functions, and the role of parent-offspring conflict in the evolution of placental traits. Given placentation has evolved independently m

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10

Jokhi, Percy Parvez. "Cytokines and their receptors in human placental implantation." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338321.

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11

Chiu, Sui Mei Linda. "Identification of a renin binding site in the human placenta." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0001/MQ29676.pdf.

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12

Jovelet, Cécile. "Interactions du vandetanib avec la P-glycoprotéine et passage d'une barrière physiologique : le placenta." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA114825.

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La surexpression de protéines d’efflux, et tout particulièrement la P-glycoprotéine, est impliquée dans la multidrug résistance. Dans cette thèse, nous démontrons que le vandetanib, inhibiteur de tyrosine kinase, est à la fois substrat et inhibiteur de la P-glycoprotéine et qu’il est capable de réverser in vitro la résistance à la doxorubicine liée à la surexpression de la P-glycoprotéine.Nous nous sommes également intéressés à l’étude du passage transplacentaire du vandetanib et nous montrons que ce médicament traverse la barrière placentaire<br>Overexpression of ABC transporters, especially

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13

Nguyen-Bresinsky, Dong Thi. "Immunopurification of Bovine Placental Lactogen." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/Nguyen-Bresinsky2005.pdf.

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14

Woo, Chit-shing Jackson, and 胡哲誠. "Ochratoxin A: endocrine disruption potential,transplacental kinetics and maternal exposure assessment." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B4979954X.

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Mycotoxin contamination in food commodities is an age-old problem. Due to the detrimental impact of mycotoxins on human health, exposure to mycotoxins and their health implications have been increasingly recognized. Ochratoxin A (OTA), one of the mycotoxins, has been found to cause diverse toxicities in animals, with potential impact on human health. OTA has been reported to be teratogenic and interfere with steroidogenesis in vivo. Chronic exposure of pregnant women to OTA may be hazardous for the human foetus, especially when endocrine and developmental toxicities are taken into considerati

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15

Ahmed, Najma Ayesha. "Studies on the regulation of chorionic gonadotropin production in explant cultures of human placenta." Thesis, McGill University, 1989. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74342.

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The effects of various steroid hormones on human chorionic gonadotropin (hCG) production and placental viability were investigated using an explant culture model of human placenta.<br>Placental hCG production was assessed using two different methods: (a) hCG concentrations in media recovered from cultures were measured by radioimmunoassay and (b) tissue levels of hCG in cultured placentae were determined immunohistochemically; both were evaluated before and after exposure to steroid hormones. In first trimester placentae, progesterone and dehydroepiandrosterone (DHEA) increased hCG concentrati

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16

Rodway, Marie R. "Effector mechanisms in the endocrine control of steroidogenesis." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/31411.

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Production of hormones in the ovary is controlled by endocrine, paracrine, autocrine and intracrine influences. Similar controls may exist in the placenta. I wished to investigate the involvement of second messengers in the action of hormones in control of hormonogenesis in rat ovary and human placenta. The second messengers involved in the action of gonadotropin-releasing hormone (GnRH) and prostaglandin (PG) F₂[formula omitted] were investigated in rat granulosa and luteal cells. As well, the endocrine role of GnRH in the placenta and the possible second messengers involved were investigated

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17

Chidzanja, Stivelia. "Restricted implantation and undernutrition alter development and growth of the ovine placenta." Title page, abstract and contents only, 1994. http://hdl.handle.net/2440/18519.

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Bibliography: 161-199.<br>[xxvi], 199, [151] leaves, [7] leaves of plates : ill. (some col.) ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Characterises the normal otogeny of the cellular composition and structure of placentomes in sheep, their relationship to the macroscopic parameters of placentome size and morphology, and the effect of experimental and natural restriction of implantation on the growth and development of placentomes between mid and late gestation.<br>Thesis (Ph.D.)--University of Adelaide, D

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18

Ritson, Anne. "The study of immunoregulatory cells in the placental bed in normal human pregnancy." Thesis, University of Leeds, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236877.

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19

Day, Priscilla Elly Liwawa. "The transfer and metabolism of glucose and amino acids by the human placenta." Thesis, University of Southampton, 2012. https://eprints.soton.ac.uk/377713/.

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20

Delidaki, Maria. "The role of CRH in placental biology : studies employing a choriocarcinoma cell line." Thesis, University of Warwick, 2011. http://wrap.warwick.ac.uk/55457/.

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The hypothalamic component of HPA–axis CRH is also produced by the placenta and it has been postulated to control a “placental clock” during pregnancy which determines the onset of parturition. However, the role of CRH in early trophoblast biology is currently unknown. In this thesis we investigated the role of CRH/CRH receptor in early placentation using the fusigenic choriocarcinoma cell line BeWo. These cells expressed functional CRH-R coupled to MAPK signalling cascades. In this cellular model, CRH was shown to promote survival and to induce cell proliferation, however in the presence of d

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21

Jackson, Moira Russell. "Stereological studies on the oxygen diffusing capacity of human placentae from low and high altitudes." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292234.

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These studies have quantified human placental development throughout 10-41 weeks of `normal' gestation, and compared the structure of term organs delivered at low (400m) and high (3600m) altitudes in Bolivia. Quantitative analyses of histological preparations were performed using stereological techniques. Salient structural parameters were then combined with physicochemical constants (gleaned from the literature) to estimate the oxygen conductances of the maternal and fetal erythrocytes and plasmas, the trophoblast and the stroma. These were combined to yield Dp, the total morphometric diffusi

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22

Hasan, Jahanara Begum. "Study of progesterone production in humanm pregnancy by early placental explants." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=39328.

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Little is known about the factors stimulating placental progesterone (P4) production at the time of the luteo-placental shift (6-8 weeks post-conception). To explore the regulatory mechanism, the effects of various steroids and peptides on the production of P4 by placental explants were studied.<br>In early placental explant culture P4 production was stimulated by 19-nortestosterone (19-NT), androstenedione (A-dione), 5$ alpha$-androstane-3$ alpha,$17$ beta$ diol (3$ alpha$-diol) and 5$ alpha$-androstane-3$ beta,$17$ beta$ diol (3$ beta$-diol). Of all the compounds tested, 19-NT had maximal ef

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23

Dunlap, Kathrin Anson. "The role of ovine betaretroviruses in uteroplacental function." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1850.

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24

White, Lloyd. "Characterisation of caspase- 14 in the human placenta : evidence for trophoblast-specific inhibition of differentiation by caspase- 14." University of Western Australia. School of Anatomy and Human Biology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0160.

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[Truncated abstract] The placenta forms a barrier regulating the transfer of gases, nutrients and wastes between the mother and the developing conceptus, and also produces hormones affecting both the fetus and the mother. This barrier is formed by the differentiation of the outer layer of the blastocyst- the trophoblast- to facilitate implantation and subsequent invasion of the uterus. The trophoblast consists of an underlying proliferative pool of cytotrophoblasts, which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast that forms the barrier between the

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25

Chura, Lindsay R. "The effect of chronic and acute maternal stress on expression of placental barrier genes in the rat /." Connect to online version, 2006. http://ada.mtholyoke.edu/setr/websrc/pdfs/mhc/2006/143.pdf.

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26

Sivakumar, Kavitha. "The impact of maternal obesity and gestational diabetes mellitus on adipose tissue and placental derived adipocytokines." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58490/.

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Pregnancy; a natural insulin resistant state; becomes exaggerated when complicated by obesity and gestational diabetes (GDM). Both obesity and GDM are associated with severe maternal and fetal complications as well as with increased risks of obesity in the offspring later in life. Little work has been performed on the levels of adipokines in lean, obese and diabetic pregnancy. This study aimed to explore the roles of three adipokines; namely, Adipsin, Acylation stimulating protein and Fibroblast Growth Factor-21, all of which are involved in insulin resistant and dysmetabolic states such as ob

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27

Vasquez, Hidalgo Manuel Alexander. "Effects of Nutrient Restriction, Realimentation, and Twinning on Plasma Volume, Umbilical Hemodynamics and Placental Characteristics in the Pregnant Adolescent Ewe." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31573.

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Reproductive physiology in production animals is a key economic component of longevity and profitability of animal farming. There are several components that can benefit or compromise adequate pregnancy periods. Sheep production is not only a very important economic activity for farmers around the United States, but sheep are also an important medical and surgical model to study human diseases. Our findings suggest that estradiol-17 beta could be involved in acute increased plasma volume early in gestation which can benefit overall gestation. We report that umbilical blood flow decreases upon

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28

Vasilopoulou, Elisavet. "The role of thyroid hormones in placental development and the importance of the thyroid hormone transporter MCT8." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1146/.

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Thyroid hormones (THs) are important for fetoplacental development. Human intrauterine growth restriction (IUGR) is associated with malplacentation and reduced fetal circulating concentration of THs. The expression of the plasma membrane TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 was characterised in human placental biopsies across gestation. The protein expression of MCT8 was increased in samples from severe IUGR compared with normal pregnancies. In vitro, triiodothyronine (T\(_3\)) decreased survival and increased apoptosis of IUGR compared with normal cytotrophoblasts, whi

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29

Berger, Sarah E. "The Effects of Endoglin and Placental Growth Factor on the Pathophysiology of Preeclampsia." Walsh University Honors Theses / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=walshhonors1524229362157203.

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30

Lok, Fong. "Role of IGF-I in ovine fetal and placental growth and development /." Title page, contents and abstract only, 1998. http://web4.library.adelaide.edu.au/theses/09PH/09phl836.pdf.

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31

Gorfu, Gezahegn. "Interaction of human blood platelets, lymphocytes and monocytes with vascular laminin isoforms /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-119-7/.

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32

Mäkikallio, K. (Kaarin). "Placental insufficiency and fetal heart: Doppler ultrasonographic and biochemical markers of fetal cardiac dysfunction." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514267370.

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Abstract The first aim of this study was to investigate the relationship between Doppler ultrasonographic parameters and biochemical markers of human fetal cardiac dysfunction and myocardial cell damage in pregnancies complicated by placental insufficiency and/or fetal growth restriction. Our second aim was to examine fetal central and peripheral hemodynamic characteristics associated with retrograde aortic isthmus net blood flow. Fetuses with significant myocardial cell damage (cTnT > 0.10 ng/ml) had increased pulsatility in the blood velocity waveforms of ductus venosus, left hepatic vein a

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33

Jeantet, Meriella Anita. "In vitro progesterone and estrone synthesis by the porcine placenta and endometrium at 30, 60 and 90 days of gestation." Thesis, Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/91126.

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The present studies were conducted to gain a better understanding of the effects of pregnenolone (P₅), human chorionic gonadotropin (hCG) and 3' 5', cyclic adenosine monophosphate ( cAMP) on porcine placental and endometrial production of progesterone (P₄), testosterone (T) and estrone (E₁) at 30, 60 and 90 days of gestation. Duplicate 300 mg samples of placenta, endometrium or both (co-incubation) were incubated in medium199 containing either no P₅, P₅, P₅ + hCG or P₅ + cAMP for either zero (control), .5, 1 or 2 h. The first study compared P₄ and E₁ production with or without addition of P₅

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34

Ferland, Suzanne. "L'activité physique comme facteur modifiable de la fonction placentaire au premier trimestre de la grossesse." Thesis, Université Laval, 2013. http://www.theses.ulaval.ca/2013/29587/29587.pdf.

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35

Erkinaro, T. (Tiina). "Fetal and placental haemodynamic responses to hypoxaemia, maternal hypotension and vasopressor therapy in a chronic sheep model." Doctoral thesis, University of Oulu, 2006. http://urn.fi/urn:isbn:9514281659.

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Abstract Knowledge of the effects of maternally administered vasopressors on human fetal and placental haemodynamics is sparse and limited to elective Caesarean deliveries in uncomplicated pregnancies. We hypothesized that, after short-term fetal hypoxaemia, which activates fetal cardiovascular compensatory mechanisms, treatment of maternal hypotension with ephedrine or phenylephrine results in divergent responses in fetal and placental haemodynamics. Chronically instrumented near-term sheep fetuses with either normal placental function or increased placental vascular resistance following pl

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36

Bahr, Brigham L. "Different Expression of Placental Pyruvate Kinase M2 in Normal, Preeclamptic, and Intrauterine Growth Restriction Pregnancies." BYU ScholarsArchive, 2014. https://scholarsarchive.byu.edu/etd/3901.

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This thesis will be organized into two chapters discussing the placental expression of two proteins, pyruvate kinase M2 (PKM2) and heat shock protein 27 (HSP 27), in human placentas. Understanding the mechanisms of placental metabolism in healthy and diseased placentas helps us understand how placenta disorders occur and how we can treat these disorders. The goal is to investigate these proteins to gain an understanding of their roles in placental disorders and help decrease maternal and fetal mortality rates. Chapter one covers the background of pyruvate kinase M2 (PKM2) in cancer and embryon

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37

Girsén, A. (Anna). "Preeclampsia and maternal type-1 diabetes: new insights into maternal and fetal pathophysiology." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514291104.

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Abstract Abnormal placentation is associated with preeclampsia and placental insufficiency, both of which increase the risk for fetal growth restriction. So far the early recognition of the risk population for preeclampsia has been problematic. The first hypothesis of this study was that in preeclampsia, the maternal serum proteomic profile is different from that in uncomplicated pregnancies, and this difference is detectable already in early pregnancy. The findings of this study demonstrate that in clinical preeclampsia the maternal serum proteomic profile is different from that in uncomplica

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38

Kimball, Rebecca Lutz. "The Role of Hypoxia on Pyruvate Kinase M2, mammalian Target of Rapamycin, Mitochondrial Function, and Cell Invasion in the Trophoblast." BYU ScholarsArchive, 2016. https://scholarsarchive.byu.edu/etd/5723.

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This thesis will be organized into two chapters discussing the role of hypoxia in the human placenta. The goal of this thesis is to characterize pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in hypoxic conditions in the trophoblast. Understanding the mechanisms of placental metabolism can lead to further treatments for placental diseases. Chapter one covers the background of intrauterine growth restriction, hypoxia, placental metabolism, and pyruvate kinase M2 (PKM2). Little is currently understood about the role of the mitochondria in placental d

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39

Tijeras, Annemilaï. "Mécanismes des anomalies du remodelage vasculaire tumoral dans un modèle de carcinome hépatocellulaire murin : implications de l'axe Placental Growth Factor/Vascular Endothelial Growth Factor Receptor-1 et de la voie Notch." Paris 7, 2010. http://www.theses.fr/2010PA077272.

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Bien que le rôle du P1GF soit encore débattu, des études ont mis en évidence le rôle du P1GF et de son récepteur, le VEGFR-1 dans la croissance tumorale et l'angiogenèse tumorale. Une étude récente a démontré q'un anticorps monoclonal anti-P1GF (aP1GF) inhibe la croissance tumorale et l'angiogenèse tumorale, y compris dans les modèles résistants aux anti-VEGF. La néo-vascularisation tumorale étant caractérisée par des vaisseaux anormaux, nous avons émis l'hypothèse que l'axe P1GFNEGFR-1 pouvait jouer un rôle dans le remodelage vasculaire anormal et que la signalisation du VEGFR-1 pouvait indui

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40

Cabello, Gérard. "Developpement et importance physiologique de la fonction thyroidienne chez l'agneau pendant la periode perinatale." Clermont-Ferrand 2, 1987. http://www.theses.fr/1987CLF2E390.

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41

Lagrange, Fabrice. "Influence de la stéréosélectivité des antiinflammatoires non stéroi͏̈diens sur leur passage transplacentaire et leur distribution articulaire : application au kétoprofène." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28777.

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42

Sakamoto, Kathia. ""Estudo dopplervelocimétrico das artérias uterinas em três períodos de gestações normais"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-03102005-152401/.

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Estudo longitudinal, prospectivo, comparativo de avaliação dopplervelocimétrica das artérias uterinas direita e esquerda em 37 gestantes normais em três períodos da gestação, acompanhadas na Clínica Obstétrica do HCFMUSP. Análise da relação S/D, índice de pulsatilidade e índice de resistência, relação com o número de incisuras e com posição da placenta. Foi observada redução nos valores dos índices durante a gestação. A relação S/D AUTE com placenta a direita apresentou média superior. A incidência de incisura foi maior no período entre a 16ª e a 24ª semana de gestação. A análise da relação en

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43

Savelyeva, Anastasia. "Population variations in placental micro-RNA expression by self identified maternal race." Thesis, 2020. https://hdl.handle.net/2144/41163.

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With differences in fetal growth patterns observed across racial demographics, interest in possible biological causes for these differences has increased. Prior works have studied the effects of insulin resistance in pregnancy on fetal fat deposition and growth in utero. One proposed mechanism to explain the physiological decrease in insulin sensitivity observed in normal pregnancy is the release of epigenetic factors such as placental miRNAs that have downstream effects on nutrient availability and fetal growth. The aim of this study was to identify placental miRNAs in women of different race

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44

Chidzanja, Stivelia. "Restricted implantation and undernutrition alter development and growth of the ovine placenta." Thesis, 1994. http://hdl.handle.net/2440/18519.

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Bibliography: 161-199.<br>[xxvi], 199, [151] leaves, [7] leaves of plates : ill. (some col.) ; 30 cm.<br>Characterises the normal otogeny of the cellular composition and structure of placentomes in sheep, their relationship to the macroscopic parameters of placentome size and morphology, and the effect of experimental and natural restriction of implantation on the growth and development of placentomes between mid and late gestation.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Obstetrics and Gynaecology, 1995

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"Expression of divalent metal transporter 1 (DMT-1) in human placenta and fetal tissues of early pregnancy." 2003. http://library.cuhk.edu.hk/record=b5891564.

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Kwan Pui-Chun.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 140-155).<br>Abstracts in English and Chinese.<br>Chapter Chapter 1 --- Introduction<br>Chapter 1.1 --- Overview --- p.1<br>Chapter 1.2 --- Iron homeostasis --- p.5<br>Chapter 1.3 --- Natural Resistance Associated Marcophage Protein (Nramp) Family --- p.15<br>Chapter 1.4 --- Divalent Metal Transporter 1 (DMT1) --- p.18<br>Chapter 1.5 --- Iron Responsive Element (IRE) and Iron Regulatory Protein (IRP) --- p.23<br>Chapter 1.6 --- Expression and localization of DMT-1 in h

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Ramesar, Shamal Vinesh. "The effect of sildenafil citrate and kraussianone-2 on pre-eclampsia-like manifestations in Sprague-Dawley rats." Thesis, 2011. http://hdl.handle.net/10413/10120.

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Pre-eclampsia, often described as toxaemia of pregnancy, historically represents one of the most widely investigated conditions relating to human reproduction. To date no firm cure has been found and a clear, well defined mechanism has not been ascribed to the pathogenesis of the disease. Researchers seem to focus on single pathways in isolation of others. The disease rather represents a multitude of possible underlying pathologies nvolving genetics, immune dysregulation, vascular maladaptation, and sociobiological factors thus complicating the approach to treatment. However, a central theme i

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Lok, Fong. "Role of IGF-I in ovine fetal and placental growth and development / Fong Lok." Thesis, 1998. http://hdl.handle.net/2440/19339.

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Bibliography: p. 190-234.<br>276 p. : ill. ; 30 cm.<br>Aims to directly test the hypothesis that restricting placental delivery of oxygen and nutrients to the fetus restricts fetal growth, in part by reducing endogenous production of insulin like growth factor-I<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Obstetrics and Gynaecology, 1999?

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"Regulation of placental progesterone biosynthesis in the baboon: Effects of advancing gestation and reduced substrate availability." Tulane University, 1998.

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Although maternal low density lipoprotein (LDL) is the primary source of cholesterol substrate for progesterone biosynthesis in the primate placental syncytiotrophoblast, the hypothesis to be tested is that the baboon trophoblast may derive significant amounts of substrate from sources secondary to the classical LDL pathway during early pregnancy or when faced with a paucity of lipoprotein-cholesterol. Expression of LDL receptor mRNA in syncytiotrophoblasts, assessed by reverse transcriptase-polymerase chain reaction (RT-PCR), was greater (P $<$ 0.05) in late than in early baboon pregnancy, al

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"Roles of leptin and the leptin receptor in placental endocrinology and angiogenesis during primate pregnancy." Tulane University, 2001.

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Leptin, the product of the LEP gene, may play an important role in pregnancy, specifically in the regulation of placental endocrinology and angiogenesis. In trophoblasts collected early in gestation, leptin increases hormone biosynthesis and metalloproteinase secretion and activation, suggesting leptin's involvement in placental function and development. Therefore, we hypothesize that: (1) estrogen regulates the expression of the leptin receptor in the placental syncytiotrophoblast and leptin, in turn, modulates the secretion of human chorionic gonadotropin (hCG), human growth hormone (hGH), a

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Farrand, Kirsten. "Impact of environmental factors on the development of corticotroph subpopulations in the fetal sheep pituitary." Thesis, 2008. http://hdl.handle.net/2440/58643.

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The prepartum surge in fetal plasma cortisol, essential for the maturation of organs in mammals and the normal timing of parturition in some species, including sheep, may result from an increase in the molar ratio of adrenocorticotropin (ACTH) to pro-opiomelanocortin (POMC) in the fetal circulation. Related to this, the cleavage of POMC to ACTH by the enzyme, prohormone convertase 1 (PC1), may be influenced by corticotrophin releasing hormone (CRH) stimulation. Accumulating evidence suggests that the capacity of individual corticotrophs to process POMC to ACTH may vary and individual corticotr

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