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Dissertations / Theses on the topic 'Placenta; Pregnancy'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Rankin, Jonathan. "Exploring the Effect of Maternal Physical Activity and Placental Region on Mitochondrial Protein Content and Function in the Placenta." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39339.

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The placenta is responsible for mediating fetal growth and development, thereby influencing health across the lifespan. Physical activity (PA) confers benefits to mother and baby during pregnancy, but little is known about its impact on the placenta. There were two purposes of this study: i) to determine if maternal PA during pregnancy influences placenta mitochondrial protein content and function, and ii) to determine if there were differences in placenta mitochondrial protein content and function in different regions of the placenta, namely proximal or distal to the centre of the placenta. H

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2

Chaudhry, Shazia Hira. "The Association of Homocysteine with Placenta-Mediated Pregnancy Complications." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39425.

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Background: Preeclampsia, small for gestational age (SGA), placental abruption, and fetal death are pregnancy complications linked to the utero-placental vasculature with serious consequences for maternal and infant well-being. Elevated homocysteine, a marker of cardiovascular disease risk, is postulated to play a role in placenta-mediated complications, but epidemiologic studies have reported inconsistent findings. The two primary objectives of this thesis were to 1: comprehensively investigate the association of homocysteine with placenta-mediated complications and examine modifying effects

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3

Albers, Renee Elizabeth. "Glycolytic Metabolism and Pregnancy Parameters in the Murine Placenta." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1513781057460423.

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4

Von, Dadelszen Peter. "Activation of maternal leukocytes in pre-eclampsia." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341959.

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5

Vailes, McCauley T. "Post-Transfer Outcomes in Cultured Bovine Embryos Supplemented with Epidermal Growth Factor, Fibroblast Growth Factor 2, and Insulin-Like Growth Factor 1." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/86273.

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The high incidence of pregnancy loss is a major issue facing the cattle industry. Use of in vitro fertilized (IVF) bovine embryos has become increasingly popular to help alleviate several of these reproductive issues and provide a means to enhance genetic gain for production traits. An uterine paracrine factor cocktail containing epidermal growth factor (EGF), fibroblast growth factor 2 (FGF2), and insulin-like growth factor 1 (IGF1) (collectively termed EFI) was recently identified as a means for improving in vitro derived bovine embryo development and trophectoderm cell numbers. The objectiv

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6

Ajne, Gunilla. "Endothelin and the regulation of peripheral and uteroplacental vascular tone during pregnancy /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-144-X/.

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7

Braga, Neto Antônio Rodrigues [UNESP]. "Influência do índice apoptótico e da imuno-expressão da survivina no prognóstico de pacientes com mola hidatiforme completa." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/106370.

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Made available in DSpace on 2014-06-11T19:35:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-09-01Bitstream added on 2014-06-13T20:46:39Z : No. of bitstreams: 1 braganeto_ar_dr_botfm.pdf: 558985 bytes, checksum: 2d6e135d455babda4cdff06b19ed7964 (MD5)<br>Financiadora de Estudos e Projetos (FINEP)<br>Avaliar a influência do índice apoptótico e da imuno-expressão da survivina em tecido molar no prognóstico e tratamento de pacientes com mola hidatiforme completa (MHC). Estudo observacional, retrospectivo, incluindo 78 pacientes com MHC diagnosticadas, tratadas e acompanhadas no Centr

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8

Ambrósio, Carlos Eduardo. "A barreira placentária em cães (Canis familiaris, Linnaeus, 1758): fluxo sanguíneo materno-fetal." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-21012005-111150/.

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Este estudo define a inter-relação microvascular materno-fetal e o desenvolvimento dos hematomas placentários durante diferentes períodos gestacionais em cães SRD. Placentas de 20, 35, 45 e 55 dias da prenhez foram perfundidas e fixadas para a investigação histológica e confecção de moldes vasculares, injetados com Mercox, e submetidos a corrosão para análise ao microscópio eletrônico de varredura. Os componentes fetais da placenta endoteliocorial e zonária anular do cão são irrigadas por dois ramos arteriais do cordão umbilical, um endereçado à cinta placentária, e outro ao hematoma margin

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9

Wright, Caroline. "Magnetic Resonance Imaging (MRI) biomarkers of placental structure and function in normal and growth restricted pregnancy." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/magnetic-resonance-imaging-mri-biomarkers-of-placental-structure-and-function-in-normal-and-growth-restricted-pregnancy(288b4214-b346-4a31-8bdd-1d4afaf65178).html.

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Fetal growth restriction (FGR) is a serious complication of human pregnancy where the fetus fails to reach its genetically pre-determined growth potential. It is a common condition, affecting 5 -15% of all pregnancies (Gardosi 2009) and is linked to a third of all antepartum deaths (CEMACH 2008). An ongoing problem for obstetricians is the difficulty in diagnosing and predicting FGR and those at highest risk of poor outcomes. Placental insufficiency is a major cause of FGR and specific abnormalities in placental morphology and function occur in this condition; constituting an abnormal FGR plac

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10

Chucri, Thaís Martins. "Imunofenotipagem de leucócitos da placenta bovina." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-10082010-180933/.

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Linfócitos e macrófagos são os principais tipos de leucócitos envolvidos no processo de tolerância materno-fetal. Os linfócitos são divididos em sub-populações de acordo com sua função e fenótipo, apesar de serem morfologicamente semelhantes. Seus tipos incluem os linfócitos T, linfócitos B e natural killers (NK). Macrófagos são células que derivam da migração dos monócitos sangüíneos para o tecido. Na placenta, os macrófagos desempenham um papel importante na regulação da apoptose, prejudicial para o desenvolvimento do embrião, e no processo de apresentação antigênica. Pouco se sabe sobre ess

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11

Lindow, S. W. "Utero-placental blood flow in hypertensive pregnancy and the effect of nifedipine administration." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/27206.

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Nifedipine, in a 5mg sublingual acute administration, causes a significant fall in the systolic, diastolic and mean arterial pressure in a mixed group of pregnant hypertensives. A concurrent, significant rise in the pulse rate was seen. The utero-placental blood flow index, which is a measure of utero-placental blood flow, was not significantly reduced following the administration of Nifedipine or a placebo. The utero-placental blood flow index was found to be a consistent measure of utero-placental blood flow in resting patients. In the absence of serious side-effects it can be concluded that

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12

Bulmer, J. N. "Studies on the immunology of the human placenta in normal and pathological pregnancy." Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354601.

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13

Kyrklund-Blomberg, Nina. "Smoking and pregnancy : with special reference to preterm birth and feto-placental unit /." Stockholm : Karolinska Institutet, 2006. http://diss.kib.ki.se/2006/91-7140-580-1/thesis.pdf.

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14

Reep, Daniel T. "Placental Eicosanoids and Sphingolipids in Preeclampsia." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5553.

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Placental dysfunction is implicated in the pathogenesis of preeclampsia. Chemical signals between the placenta and maternal circulation are a suspect cause of endothelial dysfunction and maternal hypertension. This study examined select lipid mediators of inflammation produced by the placenta. Patients were recruited from Virginia Commonwealth University’s pregnancy clinics and placentas were collected at delivery. Forty-eight-hour explant cultures of villous placental tissue were used to model lipid production. Electrospray ionization mass spectrometry was used to quantify concentrations of f

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15

Hunter, A. J. "Studies into the role of vascular endothelial growth factor in pre-eclampsia." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368545.

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16

Fotiadou, Parthena. "Effect of sodium butyrate on human placental trophoblast cells and cell lines." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322651.

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17

Drezza, Angela Luzia. "Associação entre crescimento neoplasico e gravidez : estudo do perfil hormonal e alterações placentarias em ratas prenhes potadoras do carcinossarcoma de walker 256." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314775.

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Orientador: Maria Cristina Cintra Gomes Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-11T23:17:54Z (GMT). No. of bitstreams: 1 Drezza_AngelaLuzia_M.pdf: 45412631 bytes, checksum: ce1384b3632e83597242baa2d9c4670b (MD5) Previous issue date: 2008<br>Resumo: A gravidez gera modificações no organismo materno para a implantação do blastocisto, que são provocadas por hormônios como estradiol e progesterona. O tempo e curso de gravidez dependem da unidade materno / fetal, a placenta, que é o órgão responsável pel

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18

Braga, Neto Antônio Rodrigues. "Influência do índice apoptótico e da imuno-expressão da survivina no prognóstico de pacientes com mola hidatiforme completa /." Botucatu : [s.n.], 2009. http://hdl.handle.net/11449/106370.

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Resumo: Avaliar a influência do índice apoptótico e da imuno-expressão da survivina em tecido molar no prognóstico e tratamento de pacientes com mola hidatiforme completa (MHC). Estudo observacional, retrospectivo, incluindo 78 pacientes com MHC diagnosticadas, tratadas e acompanhadas no Centro de Doenças Trofoblásticas de Botucatu/SP, Brasil, entre 1995 e 2006. Baseado nas curvas de regressão da gonadotrofina coriônica, as pacientes foram divididas em dois grupos: remissão espontânea (MHC-RE - 59 pacientes) e evolução para NTG pós-molar (MHC-NTG - 19 pacientes). Avaliação imunohistoquímica do

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19

Robineau-Charette, Pascale. "Function and Dysfunction of Fibrinogen-Like Protein 2 in Reproductive Success and Preeclampsia." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41999.

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Fibrinogen-like protein 2 (FGL2) is a known immunomodulator and prothrombinase, expressed by several subsets of immune cells. This thesis explores its potential role during the establishment of pregnancy, in mice, as well as in trophoblast function and in an immune-mediated subtype of preeclampsia (PE), in humans. We first noticed a marked subfertility in Fgl2 knockout (ko) and Fgl2 overexpressing (tg) colonies, where litters were fewer and smaller. To explain this, we mapped spatiotemporal patterns of FGL2 expression in the female reproductive tract and through the estrous cycle. FGL2 is expr

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20

Evans, Phylip Wyn. "Detection of vascular endothelial growth in maternal serum and its significance in early pregnancy." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266377.

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21

Goddard, Kalanithi Lucy Emily. "Placental Localization and Perinatal Outcome." Yale University, 2008. http://ymtdl.med.yale.edu/theses/available/etd-08132007-124118/.

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This retrospective case-control study was designed to investigate the relationship between placental localization and intrauterine growth restriction (IUGR). Pregnant women with an anatomic survey from January 1, 2000, to December 31, 2005, and delivery of the pregnancy at Yale-New Haven Hospital (YNHH) were identified using clinical and billing records. Multiple gestation, fetal anomaly, and incomplete medical information were reasons for exclusion. Cases (N=69) were consecutive pregnancies with evidence of IUGR (estimated fetal weight <10th percentile for gestational age) at last follow-up u

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22

Cordier, Anne-Gaël. "Impact de la drépanocytose sur les fonctions et le développement placentaires Sickle cell disease pregnancy paradox: Impaired placental structure with maintained fetal growth Sickle cell disease profoundly impacts TRP metabolism pregnancy." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB052.

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La drépanocytose est la maladie héréditaire autosomique récessive la plus fréquente. Elle affecte la synthèse de l'hémoglobine suite à des mutations du gène de la chaîne de la ß-globine. La falciformation des globules rouges en situation d'hypoxie se manifeste par une anémie hémolytique chronique et une vaso-occlusion microvasculaire conduisant à des lésions d'ischémie-reperfusion et à des thromboses. Les taux sériques d'IL1ß, IL6, IL8, TNF-alpha et MCP1 sont significativement plus élevés chez ces patientes et participent à l'expression de molécules d'adhésion sur les cellules endothéliales. L

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23

Gustafsson, Lidström Charlotte. "Local Immune regulation in human pregnancy : with focus on decidual macrophages." Doctoral thesis, Linköpings universitet, Klinisk immunologi, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-9985.

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During pregnancy, the woman carries a fetus partly foreign to her immune system, because of the expression of paternal antigens. Despite this, the fetus is normally tolerated and not rejected, as is often the case with organs in allogeneic transplantations. Systemic changes in maternal blood occur during pregnancy but, perhaps of greater importance, are changes in tissues locally in the uterus. The pregnant uterine endometrium, the decidua, is infiltrated by large numbers of leukocytes, mainly natural killer (NK) cells but also macrophages and T lymphocytes. Further, various cytokines are know

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24

Alyahyaei, Zahraa. "The role of IL-33 and ST2 in early pregnancy." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a6fd7c02-feeb-4fe5-b8e1-5713a65653b9.

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Regulation of the growth and differentiation of trophoblast cells is critical for successful embryo implantation and placentation. Cytokines are key players in these processes, as well as modulating the maternal immune response to prevent rejection of the conceptus. This thesis focused on the investigation of the cytokine interleukin (IL) - 33 and its receptor, ST2. ST2 has two isoforms, a functional cell surface receptor (ST2L) and a soluble decoy receptor (sST2). Previous work in this laboratory had shown that the human placenta expresses both IL-33 and sST2 at term. The aim of this thesis w

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25

Faria, Miriam Rubio. "Expressão tecido específica do fator de inibição de migração de macrófagos (Mif) na interface materno fetal em camundongos." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-25032010-145721/.

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Neste estudo caracterizamos a expressão de Mif nas células trofoblásticas (CT), placentárias e decidua (D) na gestação em camundongos.A imunolocalização foi realizada nos dias de gestação(dg) 7,5, 10,5, 13,5 e 17,5.Com cones ectoplacentários e placentas fetais (PL) realizou-se ensaios de Western blotting e qRT-PCR nos mesmos dg.D foram submetidas a qPCR.Aos 7,5 dg as CT gigantes e D apresentaram imunomarcação.Dos 10,5 ao 17,5 dg o Mif concentrou-se nas CTG e no espongiotrofoblasto.Na D, a imunomarcação foi menor que aos 7,5 dg.A expressão protéica na PL aumentou do 7,5 dg para o 10,5 dg (p=0,0

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Cureton, Natalie. "Development of nanocarriers for targeted drug delivery to the placenta." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/development-of-nanocarriers-for-targeted-drug-delivery-to-the-placenta(696cfc4f-0bd7-4fbe-9b23-d2b83a7fec7d).html.

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Pregnancy complications such as fetal growth restriction (FGR) are often attributed to poor uteroplacental blood flow, but the risk of systemic side-effects hinders therapeutic intervention. We have utilised novel placental-specific homing peptides to overcome this and have conjugated these to biocompatible liposomes. Peptide-conjugated liposomes were found to selectively bind to the outer syncytiotrophoblast layer of the human placenta and to the uteroplacental vasculature and labyrinth region of the mouse placenta. The novel vasodilator SE175 was selected as a nitric oxide donor with a favou

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27

Dubé, Chantal. "The Effect of Exercise-induced Myokines on Placental Health and Function." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/36725.

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Background: Exercise in pregnancy is associated with optimized fetal growth; however, the implicated mechanisms remain unknown. We hypothesize that exercise-induced myokines may be acting on the placenta to optimize fetal growth across gestation. Methodology: 1) Circulating profiles of 11 myokines were analyzed in 2nd trimester plasma of women characterized as active (N=14) or non-active (N=16) during pregnancy. 2) First trimester human placental explants (N=5) were treated with SPARC in a dose-dependent manner (0-150ng/ml). Metrics of placental health/function, including GLUT-4 expression/

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28

O'Reilly, James Richard. "Effects of maternal stress and obesity on human feto-placental glucocorticoid exposure." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9540.

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Fetal exposure to excess glucocorticoids has been proposed as a key determinant of pregnancy outcome, as well as a predictor of long term health of the offspring through a phenomenon known as ‘developmental programming’. Obesity and ‘stress’ during pregnancy are two potential sources of altered fetal exposure to glucocorticoids. One in five pregnant women is obese at antenatal booking, and maternal obesity increases risk of offspring complications including higher birth weight, potentially leading to long-term programming effects on the offspring. Likewise, maternal anxiety during pregnancy ha

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Paula, Carla Fagundes Silva de. "Mensuração do volume e quantificação dos índices vasculares placentários pela ultra-sonografia tridimensional com power Doppler em gestações normais." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-29012009-164440/.

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Objetivo: Confeccionar curvas de normalidade do volume e dos índices de vascularização placentária segundo a idade gestacional (IG) e o peso fetal estimado (PFE). Métodos: Durante o período compreendido entre março e novembro de 2007 foi realizado estudo observacional transversal envolvendo 280 gestantes com idades gestacionais compreendidas entre 12 a 38 semanas. As gestantes foram submetidas à ultra-sonografia para avaliação do volume placentário tridimensional calculado pelo método VOCAL com quantificação da vascularização placentária por meio dos índices vasculares: índice de vascularizaçã

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Colomina, Muela Jose Maria. "Prenatal one carbon metabolism-gene interactions, placenta trace element content and their effect on pregnancy outcomes." Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/441746.

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El metabolisme monocarbonat i els elements traça essencials afecten al desenvolupament i resultat de l'embaràs. Es desconeixen els efectes de diversos polimorfismes del metabolisme monocarbonat (MTHFR c.665C>T, BHMT c.716G>A, SLC19A1 c.80G>A i MTRR c.66A>G) durant l'embaràs i la seva possible modulació segons l'estat en folat; i quins factors estan associats amb les concentracions d'elements traça (zinc, coure, seleni i ferro) en la placenta. Aquests aspectes dels esmentats polimorfismes i elements traça s’han estudiat en 617 embarassos del Reus-Tarragona Birth Cohort i 218 placentes. Amb al

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Dunn-Fletcher, Caitlin E. "Expression and Function of Corticotropin-releasing Hormone in Anthropoid Primate Placenta." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1543581518246546.

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SANTOS, Carlos Anselmo dos. "Alterações placentárias associadas à hipertensão arterial em éguas com laminite crônica no terço final da gestação." Universidade Federal de Pelotas, 2013. http://repositorio.ufpel.edu.br/handle/ri/2506.

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Made available in DSpace on 2014-08-20T14:37:54Z (GMT). No. of bitstreams: 1 dissertacao_carlos_anselmo_dos_santos.pdf: 1427076 bytes, checksum: 1086b1dabfc021879cc96d4ab3af80a8 (MD5) Previous issue date: 2013-01-17<br>The cardiovascular changes in horses with laminitis are described since the 70's, however few studies have been conducted to demonstrate such changes in pregnant mares with chronic laminitis. The present study aims to evaluate blood pressure, heart rate, serum cortisol levels, gestational age and placental changes of pregnant mares with chronic laminitis and its consequences f

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Stenqvist, Ann-Christin. "Immunomodulation during human pregnancy : placental exosomes as vehicles of immune suppression." Doctoral thesis, Umeå universitet, Klinisk immunologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87566.

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The mammalian pregnancy comprises a challenge to the maternal immune system since the fetus is semi-allogeneic and could thus be rejected. Pregnancy success is associated with the placenta that is not only essential for oxygen supply, nourishment and pregnancy hormones but also plays a role in the protection of the fetus against maternal immunologic attack. The aim of the current studies was to elucidate the role of human placenta as an immunomodulatory organ with a special focus on placental exosomes as vehicles for establishment of maternal tolerance to the fetus. We discovered that the sync

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Viana, Laís Rosa 1988. "Avaliação do perfil de aminoácidos fetal e materno e atividade placentária em camudongas NMRI portadoras do adenocarcinoma de colon (MAC16) submetidas com dieta rica em leucina." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314497.

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Orientador: Maria Cristina Cintra Gomes Marcondes<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-20T14:33:01Z (GMT). No. of bitstreams: 1 Viana_LaisRosa_M.pdf: 2263212 bytes, checksum: 98db6fdccbbe9b7c57c880aa72c62a0f (MD5) Previous issue date: 2012<br>Resumo: A gravidez envolve várias etapas de ajustes fisiológicos, sendo que algumas complicações clínicas podem surgir ao longo deste processo. Dentre as complicações durante a gestação, o câncer destaca-se mais pela sua coexistência com essa complexa condição metaból

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Moschidou, Dafni. "A new source of stem cells in amniotic fluid and placenta in 1st trimester of pregnancy." Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5484.

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Mesenchymal stromal cells (MSC) are multipotent cells found in fetal, neonatal and adult tissues. Fetal MSC have advantageous characteristics over their adult counterparts, and the regenerative potential of fetal blood MSC has recently been shown in a model of skeletal dysplasia and renal failure. Although fetal blood MSC can be isolated during ongoing pregnancy, the clinical effectiveness of using fetal blood-derived MSC for prenatal fetal cell therapy is constrained by the invasive nature of blood sampling procedure. With amniocentesis and chorionic villus sampling (CVS), fetal MSC can be ob

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Ahmed, Tasfia. "Micronutrient Intake During Pregnancy: Effects of Excessive Folic Acid on Placental Health and Function." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32167.

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Background: In addition to a diet including fortified dietary staples, the use of prenatal multivitamin supplements among women has been shown, in some cases, to lead to excessive micronutrient intake levels for nutrients such as folic acid (FA). It was therefore hypothesized that prenatal vitamin supplementation, in addition to a standard Canadian diet, would place pregnant Canadians at risk for excessive FA intake. With little available research on the potential negative impact of excess FA intake in pregnancy, it was further proposed that high concentrations of FA may adversely affect plac

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Nordor, Akpéli. "Toward the identification of cancer/placenta epigenetic switches." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB097.

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Les cellules placentaires portent un génome différent du génome maternel, puisque 50% de leurs gènes proviennent du génome paternel. Cependant, comme les cellules cancéreuses après la transformation néoplasique, elles réussissent à envahir les tissus de leur hôte, échapper à son système immunitaire et induire une angiogenèse afin d’établir la grossesse. Les cellules cancéreuses et placentaires arborent aussi une différence majeure : alors que de tels mécanismes typiques des cancers sont incontrôlés dans les cellules cancéreuses, ils sont spatialement et temporairement contrôlés dans les cell

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Freitas, Murilo Rodrigues Barbosa de. "O efeito do selênio em ratas Wistar prenhas infectadas pela cepa Y de Trypanosoma cruzi." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-31102014-102620/.

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O selênio (Se) é um micronutriente importante na dieta de mamíferos e tem sido descrito com importante papel na função imune. É constituinte de mais de 25 selenoproteínas na forma do aminoácido selenocisteína, sendo este elemento crítico na manutenção do sistema de defesa antioxidante. Uma dieta complementar com Se pode ser benéfica no tratamento de doenças correlacionadas com altos níveis de estresse oxidativo, como a doença de Chagas, enfermidade negligenciada causada por Trypanosoma cruzi. O objetivo deste estudo foi avaliar os efeitos do Se em ratas Wistar prenhas infectadas pela cepa Y de

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Alison, Marianne. "Imagerie fonctionnelle du placenta en IRM." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112329.

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L’insuffisance placentaire par défaut de vascularisation est une pathologie fréquente de la grossesse, de diagnostic difficile, avec des complications potentiellement graves (retard de croissance intra utérin, prééclampsie). L’objectif de ce travail de Thèse a été de développer l’IRM fonctionnelle multiparamétrique pour l’exploration du placenta à 4.7 T chez la rate gestante. Matériel et méthode : L’IRM de diffusion (SE- EPI DWI) avec analyse IVIM et l’IRM dynamique avec injection de gadolinium (DCE) et haute résolution temporelle (< 1s) ont été développées puis étudiées sur un modèle murin

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Shang, Hongkai [Verfasser]. "Effects of maternal dexamethasone treatment early in pregnancy on glucocorticoid receptors in the ovine placenta / Hongkai Shang." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1082538183/34.

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Holder, Elizabeth. "The role of placental human endogenous retroviruses and shed microvesicles on the maternal immune system." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-placental-human-endogenous-retroviruses-and-shed-microvesicles-on-the-maternal-immune-system(a4dfe0ac-c938-4768-99d6-7f132c5aecf9).html.

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Objectives: Human Endogenous Retroviruses (HERVs) were originally derived from germ cell infection by exogenous retroviruses and comprise around eight per cent of the human genome. HERVs are highly expressed in the placenta, where HERV-W (syncytin 1) has been demonstrated to perform a fusogenic function. Due to their retroviral origin, placental syncytin 1 has been suggested to also be involved in modulating the maternal immune system. The placenta constantly sheds microvesicles (MV) into the maternal circulation, demonstrated to cause innate immune cell activation associated with normal pregn

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Morisawa, Nobuko. "Magnetic Resonance Imaging Manifestations of Decidualized Endometriotic Cysts: Comparative Study With Ovarian Cancers Associated With Endometriotic Cysts." Kyoto University, 2015. http://hdl.handle.net/2433/199169.

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Costa, Lia Filipa Alvarez Pereira da Mota e. "Cannabinoids impact on pregnancy: effects in trophoblast cells." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15948.

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Mestrado em Biologia Molecular e Celular<br>Cannabinoids (CBs) can be classified as: phytocannabinoids, the constituents of the Cannabis sativa plant; synthetic cannabinoids lab-synthesized and the endocannabinoids that are endogenous lipid mediators. Cannabinoid compounds activate cannabinoid receptors – CB1 and CB2. The most prevalent psychoactive phytocannabinoid is Δ9tetrahydrocannabinol (THC), but more than 60 different CBs were already identified in the plant. The best characterized endocannabinoids (eCBs) are anandamide (AEA) and 2arachidonoylglycerol (2-AG), that are involved in severa

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Nascimento, Karollina Ferreira do. "Inflamação durante a gestação: efeito da administração de lipopolissacarídeo (LPS) de Escherichia coli na expressão do fator de inibição de migração de macrófagos (MIF) na interface materno-fetal." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-13112012-104439/.

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A implantação embrionária determina eventos biológicos de fundamental importância para o desenvolvimento do embrião e para o sucesso da gestação. O fator de inibição de migração de macrófagos (MIF) é uma das muitas citocinas que atuam durante a gestação, desempenhando múltiplas funções biológicas e atividades pró-inflamatórias, em resposta a infecções ou à presença de toxinas bacterianas e estresse. Este estudo investigou a expressão de MIF na interface materno-placentária em condições infecto-inflamatórias simuladas no organismo materno pela administração de LPS de Escherichia coli, período i

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Martucci, Mariane Ferracin. "Expressão do complexo receptor CD74 - CD44 para o fator de inibição de migração de macrófagos (MIF) na interface materno placentária em camundongos." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-26102011-142651/.

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Este estudo determinou a expressão gênica e a localização tecidual de receptores do fator de inibição da migração de macrófagos (MIF) na interface materno-placentária em camundongos aos 7,5, 10,5, 13,5 e 17,5 dias de gestação (ddg). Observou-se expressão gênica dos receptores na decídua durante todo o período estudado. CD74 e CD44 foi imunolocalizado em células deciduais, endoteliais e leucócitos, sugerindo que estas populações são presuntivos alvos do diálogo parácrino trofoblasto-decídua. No compartimento fetal, a expressão de CD74 ocorreu aos 7.5 e 17,5 ddg e de CD44, durante a gestação. RN

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Hirst, Chloe. "Placental taurine transport in pre-eclampsia." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/placental-taurine-transport-in-preeclampsia(85a6b6e1-f0be-46f4-bec4-22c03183ff19).html.

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Pre-eclampsia (PE) is a serious disease affecting approximately 5% of pregnancies per annum. The disease etiology is complex but its origin lies in abnormal placental development and function. PE is associated with inflammation, increased nitrative stress and abnormal renewal of syncytiotrophoblast (STB), the transporting epithelium of the placenta. STB is renewed by cytotrophoblasts (CTBs) that proliferate, differentiate and fuse with STB and this is balanced by apoptosis. The amino acid taurine facilitates proliferation, differentiation and apoptosis in non-placental tissues. Taurine is also

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Nasiell, Josefine. "Expression and regulation of vasoactive substances, sex steroids and their receptors in placenta during normal pregnancy and preeclampsia /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-154-3.

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Chowdhury, Nishat Nailah. "Mother's weight gain during pregnancy and its effect on the gene expression of lipoprotein lipase in the placenta." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441608.

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It has been found in previous studies that there is a correlation between the placenta regulatory genes and the weight gain of the mother, Body Mass Index (BMI) as well as the birthweight of the fetus. When the mother gains weight / is overweight, this will affect the gene expression in the placenta, and in turn this triggers the weight gain of the fetus. The aim of the study was to investigate the correlation between the lipoprotein lipase gene and the mother's BMI, weight gain and the child's birth weight by extracting RNA from the placentas and analysing its quality and concentration. cDNA

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Macchiaverni, Patricia. "Caracterização quantitativa e funcional da transferência de anticorpos anti-Dermatophagoides pteronyssinus via placenta e colostro materno." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-18092008-112302/.

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Existem fortes evidências de que a supressão da hipersensibilidade nos recém nascidos pode ser mediada pela transferência de anticorpos maternos, dependendo de sua concentração e especificidade, no entanto carece estudos sobre a eficácia em humanos. Realizamos este estudo a fim de caracterizar qualitativa e quantitativamente a transmissão de anticorpos direcionados ao principal alérgeno da poeira domiciliar (Der p) via placenta e colostro materno, assim como investigar o efeito da sensibilização materna ao Der p na transferência passiva destes anticorpos. Para tais objetivos, analisamos amostr

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Deloison, Benjamin. "Imagerie fonctionnelle placentaire par résonance magnétique : étude de la perfusion placentaire." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA112256.

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L’insuffisance placentaire est une pathologie grave avec un diagnostic souvent trop tardif empêchant la mise en place de thérapeutiques efficaces. Le but de ce travail de Thèse est de développer chez la rate gestante et de transposer à l’Homme des outils d’IRM fonctionnelle (IRMf) placentaire qui permettrait une quantification de la perfusion placentaire en pratique clinique.Matériels et méthodes : Trois études en IRMf font partie de cette Thèse.Les deux premières ont été réalisées sur un modèle murin. Une séquence dynamique avec injection d’un agent de contraste (DCE) a été développée avec un

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