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Dissertations / Theses on the topic 'Placenta proteins'

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Published: 2 June 2025

Last updated: 31 July 2025

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1

Sealey, Amy Lynn. "Loss of the murine TATA-binding protein N terminus leads to placental labyrinth defects but not maternal adaptive immune responses." Thesis, Montana State University, 2007. http://etd.lib.montana.edu/etd/2007/sealey/SealeyA0507.pdf.

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2

Leavenworth, Jonathan Dean. "Investigations of cellular stress-responsive proteins and PGF gene expression in human trophoblast." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/dissertations/296.

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Placenta growth factor (PGF) expression is downregulated in preeclampsia (PE), a leading cause of maternal morbidity and mortality. The pathophysiology of PE is thought to be manifested by a poorly perfused placenta hampered by hypoxic stress. Two stress-mediate angiogenic responses include post-transcriptional regulation of mRNA stability, and regulation of PML sequestering protein. We investigate whether these mechanisms occur in hypoxic stressed trophoblast and preeclamptic placenta. Methods: To determine transcript stability, PGF mRNA was measured in normal vs. stressed conditions, and the

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3

Monteiro, Janaína Munuera. "Imunolocalização das Heat Shock Proteins (HSPs) 60 e 70 na placenta bovina." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-27062006-105146/.

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As Heat Shock Proteins (HSPs) ou proteínas do choque térmico são encontradas em todas as células e são classificadas de acordo com seu peso molecular. Dentre elas encontram-se as de 27, 60, 70, 90 e 110 kDa, sendo as mais estudadas no contexto da reprodução as da família 60 e 70. Essas proteínas são ditas como chaperoninas, em razão do seu importante papel no dobramento e desdobramento de outras proteínas celulares sem alterar sua conformação final, e são expressas frente a qualquer tipo de estresse como calor, vírus, bactéria, hormônios, diferenciação celular, etc, e influenciam nas respostas

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4

Sterle, Jodi A. "Effect of recombinant porcine somatotropin (rpST) on placental and fetal growth in gilts /." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9901288.

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5

Campbell, Fiona M. "Long-chain fatty acid transport by the human placenta : the role of fatty acid-binding proteins." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363738.

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The placenta is thought to play a vital role in the transfer of essential fatty (EFA) and their long-chain polyunsaturated derivatives (LCPUFA) from mother to the fetus. There is a preferential accumulation of these fatty acids from maternal to fetal tissues. However, little was known about the manner in which these nutrients preferentially traversed the placenta. This study investigated part of this placental transport mechanism. The results from these investigations demonstrated that the preferential transport of LCPUFA to the fetal circulation may at least be partially mediated by a prefere

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6

Bebington, Catherine. "Ubiquitin and ubiquitin-like proteins in the uterus and placenta of the human and non-human primate." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312211.

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7

White, Lloyd. "Characterisation of caspase- 14 in the human placenta : evidence for trophoblast-specific inhibition of differentiation by caspase- 14." University of Western Australia. School of Anatomy and Human Biology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0160.

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[Truncated abstract] The placenta forms a barrier regulating the transfer of gases, nutrients and wastes between the mother and the developing conceptus, and also produces hormones affecting both the fetus and the mother. This barrier is formed by the differentiation of the outer layer of the blastocyst- the trophoblast- to facilitate implantation and subsequent invasion of the uterus. The trophoblast consists of an underlying proliferative pool of cytotrophoblasts, which differentiate to replenish the overlying continuous, multi-nucleated syncytiotrophoblast that forms the barrier between the

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8

Anandavijayan, Sothinathan. "Purification and characterisation of serum retinol binding proteins and the transport of Vitamin A across the human placenta." Thesis, University of Aberdeen, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394651.

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Since retinol is insoluble in aqueous media, transport of vitamin A to epithelial tissues from its storage sites in the liver, is mediated by a specific plasma carrier protein called Retinol-Binding Protein (RBP). There have been controversial views expressed by different workers as to the mechanism of active transfer of retinol through the lipid bilayer of target cell membrane. The supply of Vitamin A and its derivatives from mother to foetus is of vital importance for fetal growth and development. Placenta plays an important role in the supply of these nutrients to the fetus. Since little is

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9

Basir, Ghazala Sikandar. "Fetoplacental circulation and the role of IGF-1 in placental remodelling by apoptosis and proliferation in diabetic pregnancies." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30496457.

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10

Dinant, Soraya. "Rôle des protéines prion au cours de l'infection par le virus influenza A chez la souris." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASB072.

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Les infections respiratoires virales constituent un problème de santé public majeur. Les virus influenza A (VIA) sont des virus zoonotiques figurant parmi les agents étiologiques responsables de ces pathologies. Dans le but d'identifier des facteurs de restriction à même de lutter contre ces agents pathogènes, nous avons réalisé plusieurs analyses qui nous ont permis d'identifier les gènes de la famille prion comme facteur d'atténuation des symptômes grippaux en modèle souris.La famille Prion est composée des trois gènes : Prnp, Prnd et Sprn qui codent respectivement les protéines PrPC, Doppel

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11

Rankin, Jonathan. "Exploring the Effect of Maternal Physical Activity and Placental Region on Mitochondrial Protein Content and Function in the Placenta." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39339.

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The placenta is responsible for mediating fetal growth and development, thereby influencing health across the lifespan. Physical activity (PA) confers benefits to mother and baby during pregnancy, but little is known about its impact on the placenta. There were two purposes of this study: i) to determine if maternal PA during pregnancy influences placenta mitochondrial protein content and function, and ii) to determine if there were differences in placenta mitochondrial protein content and function in different regions of the placenta, namely proximal or distal to the centre of the placenta. H

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12

Rao, M. Rekha. "Functional Differentiation Of The Human Placenta : Insights From The Expression Of Two Developmentally - Regulated Genes." Thesis, Indian Institute of Science, 2000. https://etd.iisc.ac.in/handle/2005/177.

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Placenta is a transient association of the fetal and maternal tissues, that develops during pregnancy, in most viviparous animals. The evolution of placenta ensured the development of the fetus inside the womb of the mother, providing a protected environment for the development of the fetus, and preventing the loss of progeny due to unfavorable environmental conditions. Because it is strategically poised at the maternal and fetal interface, the placenta is ideally suited to carry out alimentary, respiratory and excretory functions for the developing fetus. In addition, it serves as an immunolo

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13

Rao, M. Rekha. "Functional Differentiation Of The Human Placenta : Insights From The Expression Of Two Developmentally - Regulated Genes." Thesis, Indian Institute of Science, 2000. http://hdl.handle.net/2005/177.

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Placenta is a transient association of the fetal and maternal tissues, that develops during pregnancy, in most viviparous animals. The evolution of placenta ensured the development of the fetus inside the womb of the mother, providing a protected environment for the development of the fetus, and preventing the loss of progeny due to unfavorable environmental conditions. Because it is strategically poised at the maternal and fetal interface, the placenta is ideally suited to carry out alimentary, respiratory and excretory functions for the developing fetus. In addition, it serves as an immunolo

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14

Bojja, Aruna Sri. "Functional characterization of placental cathepsins." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 81 p, 2009. http://proquest.umi.com/pqdweb?did=1885754561&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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15

Benner, Gretchen E. (Gretchen Evonne). "Mechanism of Activation by Autophosphorylation of an S6/H4 Kinase Isolated From Human Placenta." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc332785/.

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A novel molecular mechanism of autophosphorylation-dependent activation of the ser/thr S6/H4 kinase isolated from human placenta is described. Phosphopeptide mapping of the enzyme was used to determine the rate and extent of site-specific autophosphorylation. These data were correlated to phosphotransferase activity of the protein kinase. The results indicated that a sequential phosphorylation of two sites in the catalytic domain is required for maximum activation. Kinetic analysis determined that site 1 is modified by an intramolecular phosphorylation, and site 2 is modified by an intermolecu

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16

Berselli, P. V. "GM3 SYNTHASE FROM HUMAN PLACENTA : GENE CLONING AND PROTEIN CHARACTERIZATION." Doctoral thesis, Università degli Studi di Milano, 2005. http://hdl.handle.net/2434/162864.

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GM3 ganglioside is the first and the simplest ganglioside: it represents the common precursor for nearly all the naturally occurring ganglioside species, and it is ubiquitously distributed on the plasma membrane of all eukaryotic cells. Moreover, GM3 itself is known to have important functions in modulation of cellular growth, in cell differentiation and in cell adhesion/recognition processes through glycosphingolipid-enriched domains [50-64]. GM3 synthase (EC 2.4.99.9, ST3Gal V) catalyzes GM3 ganglioside biosynthesis via the transfer of a sialic acid moiety from CMP-sialic acid onto LacCer

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17

Edwards, H. C. "Ca'2'+-sensitive proteins of the human placental microvillar cytoskeleton." Thesis, University of Leeds, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304146.

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18

Horie, Kiyoshige. "Expression of c-kit Protein during Placental Development." Kyoto University, 1994. http://hdl.handle.net/2433/168859.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第5666号<br>医博第1553号<br>新制||医||582(附属図書館)<br>UT51-94-J98<br>京都大学大学院医学研究科外科系専攻<br>(主査)教授西川伸一, 教授藤田潤, 教授森崇英<br>学位規則第4条第1項該当

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19

Dennis, Patrick B. (Patrick Brian). "Autophosphorylation and Autoactivation of an S6/H4 Kinase Isolated From Human Placenta." Thesis, University of North Texas, 1994. https://digital.library.unt.edu/ark:/67531/metadc279364/.

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A number of protein kinases have been shown to undergo autophosphorylation, but few have demonstrated a coordinate increase or decrease in enzymatic activity as a result. Described here is a novel S6 kinase isolated from human placenta which autoactivates through autophosphorylation in vitro. This S6/H4 kinase, purified in an inactive state, was shown to be a protein of Mr of 60,000 as estimated by SDS-PAGE and could catalyze the phosphorylation of the synthetic peptide S6-21, the histone H4, and myelin basic protein. Mild digestion of the inactive S6/H4 kinase with trypsin was necessary, but

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20

Robineau-Charette, Pascale. "Function and Dysfunction of Fibrinogen-Like Protein 2 in Reproductive Success and Preeclampsia." Thesis, Université d'Ottawa / University of Ottawa, 2021. http://hdl.handle.net/10393/41999.

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Fibrinogen-like protein 2 (FGL2) is a known immunomodulator and prothrombinase, expressed by several subsets of immune cells. This thesis explores its potential role during the establishment of pregnancy, in mice, as well as in trophoblast function and in an immune-mediated subtype of preeclampsia (PE), in humans. We first noticed a marked subfertility in Fgl2 knockout (ko) and Fgl2 overexpressing (tg) colonies, where litters were fewer and smaller. To explain this, we mapped spatiotemporal patterns of FGL2 expression in the female reproductive tract and through the estrous cycle. FGL2 is expr

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21

Hassanein, Mohamed. "Biochemical and functional characterization of a novel placental protease, cathepsin P, in rat trophoblasts." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 148 p, 2007. http://proquest.umi.com/pqdweb?did=1654487491&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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22

Williams, James M. A. "Studies on the transport of calcium across the dually perfused lobule of the human term placenta." Thesis, University of Aberdeen, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387461.

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Movements of calcium (Ca) across the maternal and fetal aspects of the human placenta were investigated using the isolated placental lobule dually perfused <I>in vitro.</I> Tissues uptakes and releases of calcium were measured and the effects on calcium movements by calcium-protein binding in the perfusion fluids, (associated with extracellular pathways and non-uniform perfusion), evaluated. The effects of ouabain, dinitrophenol (DNP), and cooling on calcium movements were measured and compared to movements of Na<sup>+</sup> and K<sup>+</sup>. These indicated the presence of active transport o

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23

Vection, Sonia. "Infection of human placental cells by Brucella : Role of the multifunctional host protein CD98hc." Thesis, Université de Montpellier (2022-….), 2022. http://www.theses.fr/2022UMONT010.

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La brucellose, une maladie infectieuse causée par les bactéries du genre Brucella, est une des plus importantes zoonoses mondiales. Maladie animale, l’infection peut être transmise à l’Homme et augmente le risque de complications obstétricales chez la femme enceinte. Durant la grossesse, les cellules placentaires spécialisées appelées trophoblastes occupent les fonctions centrales au sein du placenta. Plusieurs de ces fonctions impliquent la protéine de l’hôte CD98hc. Cette glycoprotéine de surface a été démontrée par notre équipe comme étant importante pour l’infection de différents types cel

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24

KACEMI, ABDELKRIM. "Caracterisation des proteines contractiles et culture des cellules des microvaisseaux ftaux du placenta humain." Paris 6, 1995. http://www.theses.fr/1995PA066632.

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Le placenta humain est richement irrigue et ses fonctions dependent essentiellement de sa vascularisation. Neanmoins, la physiopathologie des cellules vasculaires et perivasculaires de la circulation ftale intraplacentaire a ete peu etudiee. Dans cette etude, nous avons examine la repartition des proteines contractiles et la proportion de leurs differentes isoformes dans les vaisseaux ombilico-placentaires issus de grossesses normales. Nous avons ensuite realise l'isolement et la culture des cellules perivasculaires (cellules endotheliales et pericytes) provenant de microvaisseaux ftaux intrap

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25

Kaihola, Helena. "The Effects of SSRI Treatment on Human Placenta and Embryo." Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-248527.

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During pregnancy, 4 - 7% of women suffer from major depressive disorder. When antidepressive treatment is needed, selective serotonin reuptake inhibitors (SSRIs) are the most commonly used. Although severe complications from SSRI treatment are rare, association with a number of adverse pregnancy and fetal outcomes has been found. Also, antenatal depression per se has been shown to affect pregnancy outcomes. The overall aim of this thesis was to examine the effects of SSRIs on human placenta and embryo. In the first study, gene expression was investigated in placenta from depressed, SSRI-treate

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26

Khera, Alisha. "Selenium Supplementation Protects Placental Trophoblast Cells from Mitochondrial Oxidative Stress." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367348.

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Affecting 5-7% of all pregnancies, pre-eclampsia is a dangerous complication of pregnancy which poses a serious health risk to both mother and fetus. It is a major cause of maternal and perinatal morbidity and is characterised by hypertension, proteinuria, edema and platelet aggregation. Despite the severity of the disease, no comprehensive theory has been determined to explain the pathogenesis of the disease, with delivery being the only curative treatment of this multisystem disorder of pregnancy. Oxidative stress plays a crucial role in the pathogenesis of pre-eclampsia, which results in p

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27

Pockley, Alan G. "An investigation into the immunomodulatory activities of human placental protein 14 (PP14)." Thesis, Sheffield Hallam University, 1988. http://shura.shu.ac.uk/20238/.

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PP14 has been shown to suppress the incorporation of [3]H-Thymidine into both mitogenically and allogeneically stimulated lymphocytes in a dose dependent manner. The suppressive activity was shown to be specific, in that PP14 did not affect cellular viability, nor interact with the mitogen phytohaemagglutinin (PHA). Flow cytometric analysis indicated that PP14 had no effect on the expression of the Tac antigen, the transferrin receptor or HLA-DR molecules on the surface of stimulated lymphocytes. Neither did PP14 affect the interaction of interleukin-2 (IL-2) with its cell surface receptor. Th

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28

Funk, Mathis. "Identification et caractérisation de deux nouveaux gènes d'enveloppes rétrovirales de type syncytine, capturés pour un possible rôle dans la structure atypique du placenta de hyène et l'émergence du placenta non-mammifère des lézards Mabuya." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS106/document.

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Les syncytines sont des gènes d'enveloppes rétrovirales (env) capturés qui sont essentiels pour l'établissement du placenta chez les mammifères. Il a été proposé que la diversité des syncytines capturées explique pourquoi le placenta est l'organe le plus variable chez les mammifères. Ici nous avons employé deux approches pour étudier le lien entre la capture d'env et l'émergence et la diversité des structures placentaires. D'abord, nous avons étudié la placentation des Hyaenidae, les seuls carnivores à présenter un placenta très invasif hémochorial, comme l'humain. Comme tous les carnivores, l

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Hobbs, Nicole Kay. "Mid-and late-gestation lethality in mice lacking the N terminus of TATA-binding protein." Diss., Montana State University, 2004. http://etd.lib.montana.edu/etd/2004/hobbs/HobbsN1204.pdf.

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30

Yeboah, Dorothy. "Expression and regulation of Breast Cancer Resistance Protein in the human placenta and fetal membranes." Thesis, University of Ottawa (Canada), 2007. http://hdl.handle.net/10393/27942.

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Breast Cancer Resistance Protein, BCRP, is highly expressed in many different tumor tissues conferring multi-drug resistance against many chemotherapy drugs. BCRP has also been reported to be present in normal tissues including the human placenta during pregnancy. It is believed that in the placenta, BCRP controls the levels of toxins, drugs and xenobiotics that may cross maternal circulation into fetal circulation. The expression of BCRP was examined in the human placenta and in placental membranes (amnion and chorion leave) and attached decidua. In addition, the effect of cytokines and hypox

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31

Lekatz, Leslie Ann. "The Role of Maternal Protein Intake During Late Gestation on Placental Vascular Function." Diss., North Dakota State University, 2013. https://hdl.handle.net/10365/27116.

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Global nutrient restriction or excess can influence umbilical hemodynamics in sheep fetuses (Chapter 2). We hypothesized that a specific component of the diet, namely maternal metabolizable protein (MP), would alter placental function. When MP restriction during late gestation occurs, we hypothesized that there would be a decrease in the sensitivity to bradykinin (BK) of the placental vascular arteries. In experiment 1, ewes received one of three isocaloric dietary treatments during late gestation: MP60: 60% of MP requirements; MP80: 80% of MP requirements; and MP100: 100% of the MP requiremen

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Canfield, John. "Investigating the Role of the RNA Binding Protein LIN28 in the Human Placenta: Implications for Preeclampsia." Scholar Commons, 2018. https://scholarcommons.usf.edu/etd/7483.

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An essential event during early pregnancy is the invasion of trophoblasts into the maternal decidua, which is necessary for proper implantation and establishment of maternal-fetal interface and ultimately allows for proper nutrient exchange and immunological tolerance of the growing fetus. For this invasion to occur, cells originating from the trophectoderm undergo an epithelial to mesenchymal transition to become invasive extravillous trophoblasts and begin invading the uterine decidual tissue. Through the secretion of matrix metalloproteinases and through interactions with many cytokines and

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Elboury-Elouardirhi, Houria. "Étude sur les régulations, par des protéines non histones de l'expression du gène de l'hPL dans le placenta humain." Nancy 1, 1988. http://www.theses.fr/1988NAN10264.

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La concentration élevée de l'hPL dans la plasma de la femme enceinte, en fin de grossesse, sa sécrétion placentaire estimée à plus de 1 gramme par 24 heures, son pourcentage appréciabvle de l'ensemble des protgéines placentaires, sa structure composée d'une simple chaîne d'acides aminés, sans participation de résidus glycosylés ou phosphorylés, les inconnues actuelles concernant les mécanismes de régulation de sa production, sont les facteurs qui nous ont déterminé à réaliser sa synthèse in vitro

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Gulati, Abhishek. "FACTORS INFLUENCING PLACENTAL TRANSFER OF LOPINAVIR: BINDING, UPTAKE AND EFFLUX." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1852.

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HIV protease inhibitors are an important component of Highly Active Antiretroviral Therapy used to treat HIV infected pregnant women. They have a low placental transfer and are highly plasma protein bound. The purpose of this thesis was to characterize the factors limiting placental passage and fetal exposure to lopinavir. These factors include lopinavir plasma protein binding and uptake, cellular binding, and efflux of lopinavir in the placental trophoblast cells. First, we determined the unbound fraction of lopinavir in cord blood and characterized the binding of lopinavir to α1-acid glyco

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Carey, Erica Ashton Kayleigh. "AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377417590.

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Hewitt, Damien Phillip. "Impact of glucocorticoids on placental growth and vascularisation." University of Western Australia. School of Anatomy and Human Biology, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0195.

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[Truncated abstract] Glucocorticoids are critical for the maturation of the fetus late in pregnancy. Indeed, clinical administration of glucocorticoids is used to accelerate fetal lung maturation in mothers at risk of pre-term delivery. Increased glucocorticoid exposure, however, can have detrimental effects on fetal and placental growth and increase the risk of disease in later life. Many studies have focused on the effect of an increase in the transplacental passage of glucocorticoids on both fetal growth and subsequent postnatal development. But there is a growing body of evidence to sugges

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37

Barea, Roldán Diana [Verfasser]. "Functional characterization of the placenta specific protein PLAC1 and its use for cancer immunotherapy / Diana Barea Roldán." Mainz : Universitätsbibliothek Mainz, 2014. http://d-nb.info/1059890631/34.

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38

Chien, Fan Wui. "A study of maternal and fetal amino acid metabolism and protein turnover during normal pregnancy." Thesis, University of Dundee, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323646.

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Santos, Ursula Urias dos. "Análise funcional de CD99 na tumorigênese de astrocitomas." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-12052015-081611/.

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Astrocitomas constituem o tipo mais comum de tumor cerebral neuroepitelial primário apresentando grande heteogeneidade. De acordo com a Organização Mundial de Saúde, os astrocitomas podem ser histologicamente divididos em graus I- IV. Astrocitomas pilocíticos (grau I) são tumores circunscritos, de crescimento lento e bom prognóstico. Astrocitomas difusos (grau II) apresentam hipercelularidade, crescimento relativamente lento e propensão para invadir o tecido cerebral normaladjacente. Astrocitomas anaplásicos (grau III) apresentam aumento da celularidade, atipia nuclear e figuras mitóticas. Gli

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Rainey, Jenna. "The Regulation of Multidrug Resistance Phosphoglycoprotein (MDR1/P-gp) and Breast Cancer Resistance Protein (BCRP) in the Human Placenta." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19961.

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Multidrug resistance phosphoglycoprotein (MDR1/P-gp) and breast cancer resistance protein (BCRP) were first isolated in chemoresistant cancer cells and have since been found in a variety of normal tissue, including the placenta. The potential function of MDR1/P-gp and BCRP in the human placenta is to protect the fetus from maternally circulating endogenous steroids and hormones, therapeutic drugs and toxins. The objective of this study was to examine the role of maternal steroids in the regulation of MDR1/P-gp and BCRP in the human placenta. Trophoblast cells were isolated from term placent

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Dalton, Caroline Frances. "An investigation into placental protein 14, a modulator of the immune response associated with human reproduction." Thesis, Sheffield Hallam University, 1994. http://shura.shu.ac.uk/19530/.

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This thesis describes investigations into Placental Protein 14 (PP14), a immunomodulator involved in human reproduction. The studies included the development of a purification procedure and an investigation of the activity of the protein. In addition the cDNA coding for the protein was cloned and expressed as a recombinant fusion protein and the molecular structure of the protein was predicted and analysed using computer-assisted modelling. Finally the clinical significance of the protein was studied in a range of patient groups. The purification scheme consisted of ion exchange, hydrophobic i

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Wang, Xiuqiong. "INVESTIGATION OF THE ROLE OF ANNEXIN V IN MOUSE PLACENTA: DEVELOPMENT OF APPROACHES TO EXPLORE THE THERAPEUTIC POTENTIAL OF THE PROTIEN." Cincinnati, Ohio : University of Cincinnati, 2000. http://www.ohiolink.edu/etd/view.cgi?ucin968165255.

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Källebring, Tina. "THE EXPRESSION OF THROMBOMODULIN, TISSUE FACTOR, TISSUE FACTOR PATHWAY INHIBITOR AND ENDOTHELIAL PROTEIN C RECEPTOR IN NORMAL AND IUGR PLACENTA." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6156.

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<p>The aim of this study was to examine the expression of Thrombomodulin, Tissue Factor, Tissue Factor Pathway Inhibitor and Endothelial Protein C Receptor in placenta throughout the three phases of the third trimester in the normal placenta and in IUGR placenta from full term.</p><p>Twenty-five normal placenta samples and twenty-five IUGR placenta samples were obtained and each sample was stained by immunohistochemistry using monoclonal antibodies. Each antibody was optimised for antigen retrieval method and for optimal dilution, before been applied to the test tissue.</p><p>The results showe

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Ghazavi, Emma. "The protein expression of the nicotinic acetylcholine receptors in the human placenta, and effects of cigarette smoking and pre-eclampsia." Thesis, The University of Sydney, 2014. http://hdl.handle.net/2123/10534.

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Smoking during pregnancy is associated with low birth weight, premature delivery, neonatal morbidity, and mortality. However, smoking is associated with a reduced pre-eclampsia (PE) risk. This protective effect against PE may occur via action of nicotine on the nicotinic acetylcholine receptors (nAChRs). Using western blot and immunohistochemistry (IHC), this study investigated the protein expression of nine of the sixteen mammalian nAChR subunits (α2, α3, α4, α5, α7, α9, β1, β2 and δ) in the normal healthy human placenta (controls; n=8), and determined the effects of smoking (n=8) and PE (n=

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Marino, M. A. "ESPRESSIONE DI PROTEINE COINVOLTE NEL TRASPORTO PLACENTARE DEL FERRO IN GRAVIDANZE NORMALI E PATOLOGICHE." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/214616.

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Background Intrauterine Growth Restriction (IUGR) and Pre-eclampsia (PE) are pregnancy pathologies associated with deficient placental function, leading to decreased nutrient and oxygen availability to the fetus. Iron (Fe) deficiency in pregnancy is associated with low birth weight and premature delivery. Nevertheless, Fe oversupply promotes the generation of free radicals and causes oxidative damage in the cells. A previous study performed in the lab where this thesis has been carried out demonstrated a significant decrease of the Fe cell-importer Transferrin Receptor (TfR1), located in th

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Lecarpentier, Edouard. "Etude des flux sanguins dans le placenta humain et influence du shear stress sur la fonction biologique du syncytiotrophoblaste." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB052/document.

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La placentation humaine est de type hémomonochoriale, le sang maternel est directement en contact avec le syncytiotrophoblaste. Les flux sanguins maternels, dans la chambre intervilleuse, exercent des forces mécaniques de cisaillement (shear stress) sur la surface microvillositaire du syncytiotrophoblaste. Les effets physiologiques du shear stress exercé par les flux sanguins sur l’endothélium vasculaire artériel et veineux ont fait l’objet de nombreux travaux scientifiques. En revanche, les effets biologiques du shear stress sur le syncytiotrophoblaste humain n’ont jamais été explorés. L’obje

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BOURGEOIS, CHRISTELLE. "Expression des endothelines dans le placenta humain. Etude de leurs recepteurs couples aux proteines g dans le muscle lisse des vaisseaux villositaires." Paris 7, 1996. http://www.theses.fr/1996PA077176.

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Les endothelines (et-1, et-2, et-3) exercent des effets vasoactifs et mitogenes via leurs recepteurs et#a et et#b. Un role important de ces peptides dans le developpement de l'unite foeto-placentaire est envisage. Au cours de cette etude en fin de grossesse, nous avons, dans un premier temps, montre que les arnm de la prepro-endotheline-1 (prepro-et-1) et de la prepro-et-3 sont exprimes dans le syncytiotrophoblaste en culture. Dans la musculature lisse des vaisseaux villositaires, cibles des et, nous avons ensuite identifie des elements des voies de signalisation de ces peptides: les proteine

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Ana, Jakovljević. "Prognostički značaj laboratorijskih pokazatelja uteroplacentalne cirkulacije kod trudnica sa hipertenzijom i preeklampsijom." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2016. http://www.cris.uns.ac.rs/record.jsf?recordId=101331&source=NDLTD&language=en.

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UVOD: Hipertenzivna oboljenja u trudnoći predstavljaju heterogenu grupu bolesti koja se javljaju kod 3-8% trudnica op&scaron;te populacije. Najteže forme ovih oboljenja preeklampsija, eklampsija i HELLP sindrom su vodeći uzročnici morbiditeta i mortaliteta majke i ploda u odnosu na sve druge komplikacije u trudnoći. Etiopatogeneza ovih oboljenja je jo&scaron; uvek nedovoljno razja&scaron;njena ali se smatra da placenta ima ključnu ulogu u nastanku ovih komplikacija, odnosno da placentalna insuficijencija, koja nastaje kao posledica nedovoljne adaptacije decidualnih i intramiometrijalnih delova

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Daoud, Georges. "Implication des protéines cytoplasmiques liant les acides gras dans le transport de l'acide linoléique et identification des mécanismes impliqués dans la différenciation des cellules placentaires humaines /." Montréal : Université du Québec à Montréal, 2006. http://accesbib.uqam.ca/cgi-bin/bduqam/transit.pl?&noMan=24634896.

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Gillies, Peter John. "Modulation of dermal microvascular endithelial cell responses to growth factors and haemostatic factors in the presence of vitronectin." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/37176/1/Peter_Gillies_Thesis.pdf.

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In order to effect permanent closure in burns patients suffering from full thickness wounds, replacing their skin via split thickness autografting, is essential. Dermal substitutes in conjunction with widely meshed split thickness autografts (+/- cultured keratinocytes) reduce scarring at the donor and recipient sites of burns patients by reducing demand for autologous skin (both surface area and thickness), without compromising dermal delivery at the wound face. Tissue engineered products such as Integra consist of a dermal template which is rapidly remodelled to form a neodermis, at which ti

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