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Journal articles on the topic 'Placenta proteins'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tang, Yunhui, Katie Groom, Larry Chamley, and Qi Chen. "Melatonin, a Potential Therapeutic Agent for Preeclampsia, Reduces the Extrusion of Toxic Extracellular Vesicles from Preeclamptic Placentae." Cells 10, no. 8 (2021): 1904. http://dx.doi.org/10.3390/cells10081904.

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Preeclampsia, characterised by maternal endothelial cell activation, is triggered by toxic factors, such as placental extracellular vesicles (EVs) from a dysfunctional placenta. The increased oxidative stress seen in the preeclamptic placenta links to endoplasmic reticulum (ER) stress. The ER regulates protein folding and trafficking. When the ER is stressed, proteins are misfolded, and misfolded proteins are toxic. Misfolded proteins can be exported from cells, via EVs which target to other cells where the misfolded proteins may also be toxic. Melatonin is a hormone and antioxidant produced b

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Wu, Zhimin, Guangling Hu, Yiyu Zhang, and Zheng Ao. "IGF2 May Enhance Placental Fatty Acid Metabolism by Regulating Expression of Fatty Acid Carriers in the Growth of Fetus and Placenta during Late Pregnancy in Pigs." Genes 14, no. 4 (2023): 872. http://dx.doi.org/10.3390/genes14040872.

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Fatty acids (FAs) are essential substances for the growth and development of the fetus and placenta. The growing fetus and placenta must obtain adequate FAs received from the maternal circulation and facilitated by various placental FA carriers, including FA transport proteins (FATPs), FA translocase (FAT/CD36), and cytoplasmic FA binding proteins (FABPs). Placental nutrition transport was regulated by imprinted genes H19 and insulin-like growth factor 2 (IGF2). Nevertheless, the relationship between the expression patterns of H19/IGF2 and placental fatty acid metabolism throughout pig pregnan

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Kulikov, I. A., K. A. Artemyeva, A. P. Aleksankin, et al. "Placental and peripheral blood changes in functional morphology and immunology in patients with placenta accreta spectrum." CLINICAL AND EXPERIMENTAL MORPHOLOGY 13, no. 3 (2024): 42–52. http://dx.doi.org/10.31088/cem2024.13.3.42-52.

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Introduction. Placenta accreta spectrum is an abnormal invasion of villous trophoblast into the myometrium and one of the most severe complications of pregnancy. We aimed to study morphofunctional, molecular, and immunological changes in the placenta and peripheral blood in various types of placenta accreta spectrum.Materials and methods. The study involved 45 pregnant women who underwent ultrasound examination at weeks 35–38. According to the ultrasound data, 15 women had placenta accreta and 15 women developed placenta increta. The comparison group included 15 pregnant women without placenta

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Szendzielorz, Ewelina, and Radoslaw Spiewak. "Placental Extracts, Proteins, and Hydrolyzed Proteins as Active Ingredients in Cosmetic Preparations for Hair Loss: A Systematic Review of Available Clinical Evidence." Applied Sciences 14, no. 22 (2024): 10301. http://dx.doi.org/10.3390/app142210301.

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Placentae and their derivatives have been used in both traditional and modern medicine, as well as in cosmetic sciences. Although hair loss is frequently mentioned among problems for which the placenta is supposed to be a remedy, the evidence seems rather scarce. The aim of this study was to highlight the clinical evidence for the efficacy of placenta products against baldness and hair loss. Methods: This systematic review was performed according to PRISMA and PICO guidelines. Database searches were conducted in PubMed, Google Scholar and Scopus. Results: Among the 2922 articles retrieved by t

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Avissar, N., C. Eisenmann, J. G. Breen, S. Horowitz, R. K. Miller, and H. J. Cohen. "Human placenta makes extracellular glutathione peroxidase and secretes it into maternal circulation." American Journal of Physiology-Endocrinology and Metabolism 267, no. 1 (1994): E68—E76. http://dx.doi.org/10.1152/ajpendo.1994.267.1.e68.

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Extracellular glutathione peroxidase (eGPX) is a selenoglycoprotein distinct from cellular glutathione peroxidase (cGPX). The cDNA for eGPX has recently been cloned from human placenta. To determine whether human placenta makes both cGPX and eGPX and secretes eGPX, we used specific immunoprecipitations of 75Se metabolically labeled proteins from full-term placental explants in culture and perfused placental lobules. Placental explants and metabolically active, dually perfused placental lobules synthesized and contained both cGPX and eGPX and secreted eGPX. Perfused tissue secreted eGPX into th

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Kim, H. R., K. Naruse, H. R. Lee, T. Wakayama, C. S. Park, and D. I. Jin. "51 PROTEOMICS ANALYSIS OF PLACENTOMEGALY IN CLONED MICE." Reproduction, Fertility and Development 19, no. 1 (2007): 143. http://dx.doi.org/10.1071/rdv19n1ab51.

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A variety of mammalian species have been cloned during the past few years. However, the success rate of somatic cell nuclear transfer in animals has been extremely low with many problems. Particularly, placentomegaly is a frequent finding in cloned mice and cattle (Wakayma et al. 1999 PNAS USA 96, 14 984–14 989; Niemann et al. 2000 Theriogenology 53, 21–34). To assess protein expression profile in the placentomagaly of cloned mice produced by nuclear transfer of embryonic stem cells, we have used global proteomics approach by 2-D gel electrophoresis and mass-spectrometry with the differential

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Weber, Milena, Ivona Baričević-Jones, Romana Masnikosa, Dejan Filimonović, Željko Miković, and Olgica Nedić. "Receptors and Binding Proteins for Insulin and Insulin-Like Growth Factors in the Placenta of Healthy Mothers and Mothers with Insulin-Dependent Diabetes Mellitus." Journal of Medical Biochemistry 28, no. 1 (2009): 30–35. http://dx.doi.org/10.2478/v10011-008-0030-3.

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Receptors and Binding Proteins for Insulin and Insulin-Like Growth Factors in the Placenta of Healthy Mothers and Mothers with Insulin-Dependent Diabetes Mellitus The IGF system of human placenta consists of insulin-like growth factors (IGF)-I and -II, their receptors (IGF-1R and IGF-2R), and binding proteins (IGFBP-1 to -6). Due to many structural and metabolic similarities with insulin, the IGF system cannot be examined separately from insulin and its receptor (IR). In this study gel filtration was used to detect solubilized membrane proteins of the placenta obtained from healthy mothers and

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Taher, Shèdy, Yamilette Borja, Lucía Cabanela, et al. "Cholecystokinin, gastrin, cholecystokinin/gastrin receptors, and bitter taste receptor TAS2R14: trophoblast expression and signaling." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 316, no. 5 (2019): R628—R639. http://dx.doi.org/10.1152/ajpregu.00153.2018.

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We investigated expression of cholecystokinin (CCK) in humans and mice, and the bitter taste receptor TAS2R14 in the human placenta. Because CCK and gastrin activate the CCKBR receptor, we also explored placental gastrin expression. Finally, we investigated calcium signaling by CCK and TAS2R14. By RT-PCR, we found CCK/Cck and GAST/Gast mRNA expression in both normal human and mouse placentas, as well as in human trophoblast cell lines (TCL). Although both Cckar and – br mRNA were expressed in the mouse placenta, only CCKBR mRNA was detected in the human placenta and TCL. mRNA expression for TA

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Selvaratnam, Johanna, Haiyan Guan, James Koropatnick, and Kaiping Yang. "Metallothionein-I- and -II-deficient mice display increased susceptibility to cadmium-induced fetal growth restriction." American Journal of Physiology-Endocrinology and Metabolism 305, no. 6 (2013): E727—E735. http://dx.doi.org/10.1152/ajpendo.00157.2013.

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Maternal cadmium exposure induces fetal growth restriction (FGR), but the underlying mechanisms remain largely unknown. The placenta is the main organ known to protect the fetus from environmental toxins such as cadmium. In this study, we examine the role of the two key placental factors in cadmium-induced FGR. The first is placental enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which is known to protect the fetus from exposure to high cortisol levels and subsequently FGR, and the second the cadmium binding/sequestering proteins metallotheionein (MT)-I and -II. Using the MT-I/II −

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Kumar K. V., Anil, Kavitha S., and Sreekanth K. S. "Regulatory proteins in placental angiogenesis." Biomedicine 41, no. 4 (2021): 694–700. http://dx.doi.org/10.51248/.v41i4.944.

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The vasculature of the placenta plays a crucial role during the course of pregnancy in order to maintain the growing need of the fetus. Abnormal placental structure and function significantly increase the risk of stillbirth. Various growth factors and cytokines play an important role in the vasculogenesis and angiogenesis of placenta. These processes are stimulated by various pro-angiogenic factors. The activities of these factors are also stimulated by hypoxia. In some of the physiological phenomenon like ovulation, embryogenesis as well as in wound healing intense blood vessel growth can be

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Kingdom, John, Ian Mackie, Stephen Burrell, et al. "Ontogeny of Beta 2 Glycoprotein I and Annexin V in Villous Placenta of Normal and Antiphospholipid Syndrome Pregnancies." Thrombosis and Haemostasis 84, no. 07 (2000): 32–38. http://dx.doi.org/10.1055/s-0037-1613963.

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Summaryβ2-glycoprotein I (β2GPI) and annexin V (AV) have been implicated in the pathophysiology of the antiphospholipid syndrome (APS). We investigated their placental expression in normal villous tissues throughout gestation; first trimester n = 10, early second trimester; n = 4, preterm; n = 5) and term; n = 7 and in APS (2 first trimester, 1 preterm and 8 term deliveries). β2GPI and AV were both expressed by the placenta from as early as seven weeks gestation and were colocalised to the syncytiotrophoblast. β2GPI staining was also observed in stromal cells, being present in phagocytic Hofba

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McKinnon, Brett, Huika Li, Kerry Richard, and Robin Mortimer. "Synthesis of Thyroid Hormone Binding Proteins Transthyretin and Albumin by Human Trophoblast." Journal of Clinical Endocrinology & Metabolism 90, no. 12 (2005): 6714–20. http://dx.doi.org/10.1210/jc.2005-0696.

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Context: Mechanisms regulating materno-fetal transfer of thyroid hormone are not well understood. Modulation of trophoblast type 3 iodothyronine deiodinase (D3) may play an important role. Objective: The objective of this study was to investigate trophoblast thyroid hormone binding proteins that may modulate interactions between D3 and T4. Design: Placentas were obtained by informed consent from women delivering normal infants by repeat cesarean section at 38–40 wk gestation. T4 and T3 binding was examined in human placenta. Serum thyroid hormone binding proteins were identified by Western blo

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Borges-Vélez, Gabriel, Juan A. Arroyo, Yadira M. Cantres-Rosario, et al. "Decreased CSTB, RAGE, and Axl Receptor Are Associated with Zika Infection in the Human Placenta." Cells 11, no. 22 (2022): 3627. http://dx.doi.org/10.3390/cells11223627.

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Zika virus (ZIKV) compromises placental integrity, infecting the fetus. However, the mechanisms associated with ZIKV penetration into the placenta leading to fetal infection are unknown. Cystatin B (CSTB), the receptor for advanced glycation end products (RAGE), and tyrosine-protein kinase receptor UFO (AXL) have been implicated in ZIKV infection and inflammation. This work investigates CSTB, RAGE, and AXL receptor expression and activation pathways in ZIKV-infected placental tissues at term. The hypothesis is that there is overexpression of CSTB and increased inflammation affecting RAGE and A

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Grimaldi, Brooke, Hamid-Reza Kohan-Ghadr та Sascha Drewlo. "The Potential for Placental Activation of PPARγ to Improve the Angiogenic Profile in Preeclampsia". Cells 11, № 21 (2022): 3514. http://dx.doi.org/10.3390/cells11213514.

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Preeclampsia (PE) is one of the most common causes of maternal-fetal morbidity and mortality world-wide. While the underlying causes of PE remain elusive, aberrant trophoblast differentiation and function are thought to cause an imbalance of secreted angiogenic proteins resulting in systemic endothelial dysfunction and organ damage in the mother. The placental dysfunction is also characterized by a reduction of the transcription factor, peroxisome proliferator activated receptor γ (PPARγ) which normally promotes trophoblast differentiation and healthy placental function. This study aimed to un

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Blumenstein, M., J. A. Keelan, J. M. Bowen-Shauver, and M. D. Mitchell. "Suppressors of cytokine signaling proteins in human preterm placental tissues." Journal of Molecular Endocrinology 35, no. 1 (2005): 165–75. http://dx.doi.org/10.1677/jme.1.01767.

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Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous preterm deliveries with intrauterine infection. SOCS1, −2 and −3 mRNAs and proteins were detectable by RT-PCR and immunoblotting respectively, in preterm amnion, choriodecidua and placenta, irrespective of infection status. Immunoperoxidase staining localized SOCS1, −2 and −3 to all c

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Bartho, Lucy A., Joshua J. Fisher, Sarah L. Walton, Anthony V. Perkins, and James S. M. Cuffe. "The effect of gestational age on mitochondrial properties of the mouse placenta." Reproduction and Fertility 3, no. 1 (2022): 19–29. http://dx.doi.org/10.1530/raf-21-0064.

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Mitochondria are organelles within the cell that generate energy, which is essential to the developing placenta. As the placenta approaches term, organelles such as mitochondria and the endoplasmic reticulum adapt to cellular stressors (e.g. oxidative stress and fluctuations in oxygen concentration) which are likely to result in the progressive decline of tissue function, known as placental ageing. This ageing phenotype may induce cellular senescence, a process whereby the cell is no longer proliferating, yet remains metabolically active. Mitochondria, endoplasmic reticulum and senescent proce

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Zhao, Xiaoyu, Shanshan Wu, Yuan Yun, et al. "Integrating Transcriptomics, Proteomics, and Metabolomics to Investigate the Mechanism of Fetal Placental Overgrowth in Somatic Cell Nuclear Transfer Cattle." International Journal of Molecular Sciences 25, no. 17 (2024): 9388. http://dx.doi.org/10.3390/ijms25179388.

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A major factor limiting the development of somatic cell nuclear transfer (SCNT) technology is the low success rate of pregnancy, mainly due to placental abnormalities disrupting the maternal-fetal balance during pregnancy. Although there has been some progress in research on the abnormal enlargement of cloned bovine placenta, there are still few reports on the direct regulatory mechanisms of enlarged cloned bovine placenta tissue. In this study, we conducted sequencing and analysis of transcriptomics, proteomics, and metabolomics of placental tissues from SCNT cattle (n = 3) and control (CON)

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Zhang, Yi, Yunhui Tang, Xinyi Sun, et al. "Exporting Proteins Associated with Senescence Repair via Extracellular Vesicles May Be Associated with Early Pregnancy Loss." Cells 11, no. 18 (2022): 2772. http://dx.doi.org/10.3390/cells11182772.

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Introduction: Dysfunction of placental development is involved in early pregnancy loss. Senescent changes have been seen in missed miscarriage, one type of pregnancy loss. Extracellular vesicles (EVs) have been widely implicated in the pathogenesis of diseases. In this study, we investigated the protein profiles in placental EVs derived from missed miscarriage in comparison with healthy pregnancy. We also investigated whether cargos packed into EVs are involved in the dysfunctional development of the placenta seen in missed miscarriage. Methods: Proteomic analysis of placental EVs derived from

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Szenasi, Nikolett Lilla, Eszter Toth, Andrea Balogh, et al. "Proteomic identification of membrane-associated placental protein 4 (MP4) as perlecan and characterization of its placental expression in normal and pathologic pregnancies." PeerJ 7 (June 20, 2019): e6982. http://dx.doi.org/10.7717/peerj.6982.

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BackgroundMore than 50 human placental proteins were isolated and physico-chemically characterized in the 70–80s by Hans Bohn and co-workers. Many of these proteins turned to have important role in placental functions and diagnostic significance in pregnancy complications. Among these proteins was membrane-associated placental protein 4 (MP4), for which identity or function has not been identified yet. Our aim was to analyze the sequence and placental expression of this protein in normal and complicated pregnancies including miscarriage, preeclampsia and HELLP syndrome.MethodsLyophilized MP4 p

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Kim, H. R., J. K. Kang, J. T. Yoon, H. H. Seong, C. S. Park, and D. I. Jin. "46DIFFERENTIAL PATTERNS OF PROTEIN SYNTHESIS BETWEEN NORMAL AND CLONED PLACENTAE." Reproduction, Fertility and Development 16, no. 2 (2004): 145. http://dx.doi.org/10.1071/rdv16n1ab46.

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Practical application of animal cloning by somatic cell nuclear transfer (SCNT) has been hampered by extremely low success rate. Most clones die before birth and survivors frequently display abnormalities. It is speculated that epigenetic reprogramming is somehow defective in reconstituted embryos (Reik W et al., 2003 Theriogenology 59 21–32; Han YM et al., 2003 Theriogenology 59, 33–44). It is likely that placental anomalies are directly or indirectly responsible for the death of cloned fetus and neonates. To address this question, we analyzed protein patterns of two placentae obtained after

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Kim, H. R., J. K. Kang, J. T. Yoon, et al. "223 ABERRENT TIMP-2 GENE EXPRESSION IN CLONED BOVINE NEONATAL PLACENTA IS DUE TO ABNORMAL EPIGENETIC MODIFICATIONS." Reproduction, Fertility and Development 17, no. 2 (2005): 262. http://dx.doi.org/10.1071/rdv17n2ab223.

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A global proteomics approach by 2-D gel electrophoresis and mass spectrometry was used to analyze the differential protein patterns of three placentae obtained after postnatal death of fetuses from SCNT of Korean Native cattle and three normal placentae obtained after birth of AI fetuses, as previously reported (Kim et al. 2004 Reprod. Fertil. Develop. 16, 145). One differentially up-regulated proteins in SCNT placenta was identified as TIMP-2 protein that is related to extracellular matrix degradation and tissue remodeling processes. To ensure that the identified protein was truly up-regulate

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Rampon, Christine, Stéphanie Bouillot, Adriana Climescu-Haulica, et al. "Protocadherin 12 deficiency alters morphogenesis and transcriptional profile of the placenta." Physiological Genomics 34, no. 2 (2008): 193–204. http://dx.doi.org/10.1152/physiolgenomics.00220.2007.

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Protocadherins are transmembrane proteins exhibiting homophilic adhesive activities through their extracellular domain. Protocadherin 12 ( Pcdh12) is expressed in angiogenic endothelial cells, mesangial cells of kidney glomeruli, and glycogen cells of the mouse placenta. To get insight into the role of this protein in vivo, we analyzed PCDH12-deficient mice and investigated their placental phenotype. The mice were alive and fertile; however, placental and embryonic sizes were reduced compared with wild-type mice. We observed defects in placental layer segregation and a decreased vascularizatio

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Guernsey, Michael W., Henri van Kruistum, David N. Reznick, Bart J. A. Pollux, and Julie C. Baker. "Molecular Signatures of Placentation and Secretion Uncovered in Poeciliopsis Maternal Follicles." Molecular Biology and Evolution 37, no. 9 (2020): 2679–90. http://dx.doi.org/10.1093/molbev/msaa121.

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Abstract Placentation evolved many times independently in vertebrates. Although the core functions of all placentas are similar, we know less about how this similarity extends to the molecular level. Here, we study Poeciliopsis, a unique genus of live-bearing fish that have independently evolved complex placental structures at least three times. The maternal follicle is a key component of these structures. It envelops yolk-rich eggs and is morphologically simple in lecithotrophic species but has elaborate villous structures in matrotrophic species. Through sequencing, the follicle transcriptom

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Mayeur, Sylvain, Steve Lancel, Nicolas Theys, et al. "Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats." American Journal of Physiology-Endocrinology and Metabolism 304, no. 1 (2013): E14—E22. http://dx.doi.org/10.1152/ajpendo.00332.2012.

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Low birth weight is associated with an increased risk for developing type 2 diabetes and metabolic diseases. The placental capacity to supply nutrients and oxygen to the fetus represents the main determiner of fetal growth. However, few studies have investigated the effects of maternal diet on the placenta. We explored placental adaptive proteomic processes implicated in response to maternal undernutrition. Rat term placentas from 70% food-restricted (FR30) mothers were used for a proteomic screen. Placental mitochondrial functions were evaluated using molecular and functional approaches, and

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Li, Ji-Wei, Jian Hu, Ming Wei, Ying-Ying Guo, and Pei-Shi Yan. "The Effects of Maternal Obesity on Porcine Placental Efficiency and Proteome." Animals 9, no. 8 (2019): 546. http://dx.doi.org/10.3390/ani9080546.

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Maternal obesity is associated with impaired maternal metabolism and affects the developmental programming of the fetus. The placenta is dysfunctional when exposed to an obese intrauterine environment and can transduce and mediate detrimental maternal impacts to the fetus through mechanisms that remain largely unknown. The main objective of this study was to investigate the effects of maternal obesity on the porcine placental proteome and to analyze the deregulated proteins and potential pathways predicted to be disturbed in obese placentas, using sows with high backfat as a model of obese pre

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Jeung, E. B., and H. Yang. "81 MEMBRANE AND CYTOSOLIC CALCIUM PROTEINS, TRPV6, PMCA1, NCKX3, NCX1 AND CaBP-28k, APPEAR TO BE DISTINCTLY REGULATED IN HUMAN CHORIOCARCINOMA AND PLACENTAL CELLS." Reproduction, Fertility and Development 24, no. 1 (2012): 153. http://dx.doi.org/10.1071/rdv24n1ab81.

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Preeclampsia is a pregnancy-specific disease characterised by de novo development of concurrent hypertension, proteinuria and oxidative stress in the placenta. In the placenta, intervillous blood flow increases after 10 weeks of gestation and results in exposure of trophoblast cells to oxygen. Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. Ca2+ is a universal intracellular second messenger involved in many processes such as signal transduction, hormone secretion and programmed cell death. Human placental primary cell c

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Wang, Joyce, Qing Qiu, Maliha Haider, Michael Bell, Andrée Gruslin, and Julian K. Christians. "Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse." Journal of Endocrinology 202, no. 3 (2009): 337–45. http://dx.doi.org/10.1677/joe-09-0136.

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Pregnancy-associated plasma protein-A and -A2 (PAPPA and PAPPA2) are proteases that cleave IGF binding proteins (IGFBPs) and thereby increase the bioavailability of growth factors. PAPPA has long been recognized as a marker of fetal genetic disorders and adverse pregnancy outcomes. In contrast, although PAPPA2 is also highly expressed in human placenta, its physiological importance is not clear. To establish whether mice will be a useful model for the study of PAPPA2, we compared the patterns of expression of PAPPA2 in the placentae of mouse and human. We show, for the first time, that Pappa2

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Mark, P. J., J. L. Lewis, M. L. Jones, and B. J. Waddell. "158. THE UNFOLDED PROTEIN RESPONSE MAY CONTRIBUTE TO GLUCOCORTICOID-INDUCED PLACENTAL GROWTH RESTRICTION IN THE RAT VIA INCREASED PLACENTAL EXPRESSION OF HEAT SHOCK PROTEIN 70." Reproduction, Fertility and Development 22, no. 9 (2010): 76. http://dx.doi.org/10.1071/srb10abs158.

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Perturbations of normal endoplasmic reticulum (ER) physiology occur in a number of pathological conditions, including diabetes and preeclampsia. These pathologies are associated with elevated levels of inappropriately folded proteins and induction of ER stress. Accumulation of misfolded proteins induces the unfolded protein response which increases ER protein folding capacity and promotes ER-associated degradation of unfolded proteins. Glucocorticoids are essential for maturation of fetal organs, however excess exposure during pregnancy retards fetal and placental growth. Glucocorticoids also

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Sun, Luming, Jia Zhou, Kai Wang, et al. "Placental Up-Regulation of Leptin and ARMS2 is Associated with Growth Discordance in Monochorionic Diamniotic Twin Pregnancies." Twin Research and Human Genetics 20, no. 2 (2017): 169–79. http://dx.doi.org/10.1017/thg.2017.11.

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Fetal growth discordance is a relatively common complication of monochorionic diamniotic (MCDA) twin pregnancies and is caused by a combination of maternal and placental factors. The aim of the study was to survey placental gene expression patterns and identify genes associated with growth discordance. Clinical samples comprised eight growth-discordant MCDA twin placentas (31+3–34+4 weeks gestational age) and six growth-concordant twin placentas (31+2–37 weeks gestational age). Gene expression libraries were constructed from placental biopsy samples and analyzed by RNA-sequencing. The distribu

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Morgan, Elizabeth, Grace Chung, Seokwon Jo, Briana Clifton, Sarah A. Wernimont, and Emilyn U. Alejandro. "Gene and Protein Expression of Placental Nutrient-Stress Sensor Proteins in Fetal Growth Restriction." Stresses 4, no. 2 (2024): 308–19. http://dx.doi.org/10.3390/stresses4020019.

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Fetal growth restriction (FGR) and low birth weight increase the risk of non-communicable diseases such as type 2 diabetes and heart failure in adulthood. Placental insufficiency is widely considered a major contributor to FGR. Two crucial placental proteins involved in nutrient and stress sensing—O-linked N-acetylglucosamine transferase (OGT) and mechanistic target of rapamycin (mTOR) kinase—play roles in post-translational protein modification and protein translation, influencing cellular growth and metabolism in response to maternal stress, hypoxia, and nutritional status in the placenta. I

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Pogorelova, T. N., V. O. Gunko, A. A. Nikashina, A. A. Mikhelson, I. A. Alliluev, and A. V. Larichkin. "Impairment of production and posttranslational changes of placental nuclear and membrane proteins with complicated pregnancy." Biomeditsinskaya Khimiya 65, no. 6 (2019): 513–19. http://dx.doi.org/10.18097/pbmc20196506513.

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The content of nuclear and membrane proteins of the placenta, as well as posttranslational modification of these proteins in physiological pregnancy and placental insufficiency (PI) were studied. Differential centrifugation, electrophoresis in polyacrylamide gel, spectrophotometric methods were used. It was found that with PN there is a decrease in the degree of production of the studied proteins of varying degrees relative to control parameters. For chromatin proteins, a more pronounced decrease in the content of non-histone proteins was found in comparison with histones. Among histone fracti

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Cao, Chang, Richa Saxena, and Kathryn J. Gray. "Placental Origins of Preeclampsia: Insights from Multi-Omic Studies." International Journal of Molecular Sciences 25, no. 17 (2024): 9343. http://dx.doi.org/10.3390/ijms25179343.

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Preeclampsia (PE) is a major cause of maternal and neonatal morbidity and mortality worldwide, with the placenta playing a central role in disease pathophysiology. This review synthesizes recent advancements in understanding the molecular mechanisms underlying PE, focusing on placental genes, proteins, and genetic variants identified through multi-omic approaches. Transcriptomic studies in bulk placental tissue have identified many dysregulated genes in the PE placenta, including the PE signature gene, Fms-like tyrosine kinase 1 (FLT1). Emerging single-cell level transcriptomic data have revea

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Lakhno, Yuliya. "Influence of hyperandrogenism in anamnesis on endocrinological status and content of placental proteins in a fetoplacental complex." Perinatology and reproductology: from research to practice 4, no. 4-1 (2025): 16–22. https://doi.org/10.52705/2788-6190-2024-04.1-02.

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The objective: study of the state of endocrinology status and content of placenta proteins of fetoplacental complex for women from hyperandrogenism in anamnesis.Materials and methods. For the decision of the put purpose studied the features of premorbid background, motion of pregnancy and functional state of fetoplacental complex (endocrinological status and content of placental proteins) in 50 women from hyperandrogenism in anamnesis – I group. For comparison used analogical information in 50 obstetric and somatically healthy women, vaginal delivery is a control group. To the complex of metho

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Tissot van Patot, M. C., J. Bendrick-Peart, V. E. Beckey, N. Serkova, and L. Zwerdlinger. "Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia." American Journal of Physiology-Lung Cellular and Molecular Physiology 287, no. 3 (2004): L525—L532. http://dx.doi.org/10.1152/ajplung.00203.2003.

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Vascularity is increased in placentas from high- compared with low-altitude pregnancies. An angiogenic response to hypoxia may protect an organ from further hypoxic insult by increasing blood flow and oxygen delivery to the tissue. We hypothesized that increased placental vascularity is sufficient to adapt to high altitude. Therefore, indexes of hypoxic stress would not be present in placentas from successful high-altitude pregnancies. Full-thickness placental biopsies were 1) collected and frozen in liquid nitrogen within 5 min of placental delivery and 2) fixed in formalin for stereologic an

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Chassen, Stephanie Skuby, Veronique Ferchaud-Roucher, Madhulika B. Gupta, Thomas Jansson, and Theresa L. Powell. "Alterations in placental long chain polyunsaturated fatty acid metabolism in human intrauterine growth restriction." Clinical Science 132, no. 5 (2018): 595–607. http://dx.doi.org/10.1042/cs20171340.

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Fatty acids (FA) are critical for fetal brain development and are transferred across the placenta by membrane-bound FA transport proteins (FATP), translocases (FAT/CD36), and cytosolic binding proteins (FABP). The cytosolic protein perilipin-2 aids in neutral lipid storage within lipid droplets. Decreased placental nutrient transport is believed to contribute to intrauterine growth restriction (IUGR); however, IUGR placental lipid transport and metabolism are poorly understood. We hypothesized that protein expression of FATPs, FABPs, and perilipin-2 in human placenta is decreased and placental

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Ashraf Soliman, Noor Hamed, Fawzia Alyafei, et al. "Insulin like growth factor 1 (IGF-1) and IGF binding proteins in obese pregnant women and their babies: Potential effects on placental function and fetal growth." World Journal of Advanced Research and Reviews 17, no. 2 (2023): 093–100. http://dx.doi.org/10.30574/wjarr.2023.17.2.0222.

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Introduction: The placenta expresses significant amounts of insulin and IGF1 receptors at distinct locations on both fetal and maternal surfaces. This makes the IGF1 and the insulin receptor accessible to fetal and/or maternal insulin, IGF1 and IGF2. IGFs are involved in the receptor-mediated regulation of placental growth and transport, and placental angiogenesis. Maternal obesity during gestation mediates significant changes in the metabolism of mothers, placentas as well as fetal growth. Objectives: In obese women. the role of the insulin like growth factor system IGFs, IGF receptors, IGF-b

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Ashraf, Soliman, Hamed Noor, Alyafei Fawzia, et al. "Insulin like growth factor 1 (IGF-1) and IGF binding proteins in obese pregnant women and their babies: Potential effects on placental function and fetal growth." World Journal of Advanced Research and Reviews 17, no. 2 (2023): 093–100. https://doi.org/10.5281/zenodo.8093130.

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<strong>Introduction</strong>: The placenta expresses significant amounts of insulin and IGF1 receptors at distinct locations on both fetal and maternal surfaces. This makes the IGF1 and the insulin receptor accessible to fetal and/or maternal insulin, IGF1 and IGF2. IGFs are involved in the receptor-mediated regulation of placental growth and transport, and placental angiogenesis. Maternal obesity during gestation mediates significant changes in the metabolism of mothers, placentas as well as fetal growth. <strong>Objectives</strong>: In obese women. the role of the insulin like growth factor

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Okamoto, Yoko, Masahiro Sakata, Kazuhiro Ogura, et al. "Expression and regulation of 4F2hc and hLAT1 in human trophoblasts." American Journal of Physiology-Cell Physiology 282, no. 1 (2002): C196—C204. http://dx.doi.org/10.1152/ajpcell.2002.282.1.c196.

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The neutral amino acid transport system L is a sodium-independent transport system in human placenta and choriocarcinoma cells. Recently, it was found that the heterodimer composed of hLAT1 (a light-chain protein) and 4F2 heavy chain (4F2hc), a type II transmembrane glycoprotein, is responsible for system L amino acid transport. We found that the mRNAs of 4F2hc and hLAT1 were expressed in the human placenta and a human choriocarcinoma cell line. The levels of the 4F2hc and hLAT1 proteins in the human placenta increased at full term compared with those at midtrimester. Immunohistochemical data

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Barreto, Rodrigo da Silva Nunes, Ana Claudia Oliveira Carreira, Mônica Duarte da Silva, et al. "Mice Placental ECM Components May Provide A Three-Dimensional Placental Microenvironment." Bioengineering 10, no. 1 (2022): 16. http://dx.doi.org/10.3390/bioengineering10010016.

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Bioethical limitations impair deeper studies in human placental physiology, then most studies use human term placentas or murine models. To overcome these challenges, new models have been proposed to mimetize the placental three-dimensional microenvironment. The placental extracellular matrix plays an essential role in several processes, being a part of the establishment of materno-fetal interaction. Regarding these aspects, this study aimed to investigate term mice placental ECM components, highlighting its collagenous and non-collagenous content, and proposing a potential three-dimensional m

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Rebholz, Sandra L., Katie T. Burke, Qing Yang, Patrick Tso, and Laura A. Woollett. "Dietary fat impacts fetal growth and metabolism: uptake of chylomicron remnant core lipids by the placenta." American Journal of Physiology-Endocrinology and Metabolism 301, no. 2 (2011): E416—E425. http://dx.doi.org/10.1152/ajpendo.00619.2010.

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The fetus requires significant energy for growth and development. Although glucose is a major source of energy for the fetus, other maternal nutrients also appear to promote growth. Thus, the goal of these studies was to determine whether triglyceride-rich remnants are taken up by the placenta and whether maternal dietary lipids, independently of adiposity, can impact fetal growth. To accomplish our first goal, chylomicron particles were duallly labeled with cholesteryl ester and triglycerides. The placenta took up remnant particles/core lipids at rates greater than adipose tissue and skeletal

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Schaiff, W. Timothy, F. F. (Russ) Knapp, Yaacov Barak, Tal Biron-Shental, D. Michael Nelson та Yoel Sadovsky. "Ligand-Activated Peroxisome Proliferator Activated Receptor γ Alters Placental Morphology and Placental Fatty Acid Uptake in Mice". Endocrinology 148, № 8 (2007): 3625–34. http://dx.doi.org/10.1210/en.2007-0211.

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The nuclear receptor peroxisome proliferator activated receptor γ (PPARγ) is essential for murine placental development. We previously showed that activation of PPARγ in primary human trophoblasts enhances the uptake of fatty acids and alters the expression of several proteins associated with fatty acid trafficking. In this study we examined the effect of ligand-activated PPARγ on placental development and transplacental fatty acid transport in wild-type (wt) and PPARγ+/− embryos. We found that exposure of pregnant mice to the PPARγ agonist rosiglitazone for 8 d (embryonic d 10.5–18.5) reduced

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Ziegert, M., S. S. Witkin, I. Sziller, H. Alexander, E. Brylla, and W. Härtig. "Heat Shock Proteins and Heat Shock Protein-Antibody Complexes in Placental Tissues." Infectious Diseases in Obstetrics and Gynecology 7, no. 4 (1999): 180–85. http://dx.doi.org/10.1155/s1064744999000307.

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Objective:The relationship between pregnancy outcome and expression of the heat shock proteins (hsps) or hsp-antibody complexes of 60kD (hsp60), 70kD (hsp70), and 90kD (hsp90) in placental tissue and circulating antibodies to hsps was evaluated.Method:Expression of hsp60, hsp70, and hsp90 in placentae from 12 women with preterm birth, eight with intrauterine growth restriction (IUGR), and 10 with term birth, as well as the presence of the corresponding antibodies, was investigated by a new carbocyanine double fluorescence technique. Results were compared with microbiological findings and circu

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Manasova, G. S., and Y. O. Stasii. "Immunohistochemical assessment of epidermal growth factor receptor and prohibitin expression in “post-COVID” placentas: results of a comparative cross-sectional study." REPRODUCTIVE ENDOCRINOLOGY, no. 72 (June 30, 2024): 77–86. https://doi.org/10.18370/2309-4117.2024.72.77-86.

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Background. COVID-19 pandemic is accompanied by a considerable number of morbidity cases among pregnant women. Certain knowledge has been accumulated about the histopathological features of the placenta during SARS-CoV-2 infection. Specific proteomic studies of the function of the placenta are insufficient.Objective of the study: to study the perinatal outcomes of pregnancy and histopathological features of the placenta and the expression of epidermal growth factor receptors (EFGR) and prohibitin (PHB) in the placenta in pregnant women with COVID-19 infection in comparison with data in a group

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Hay, WW. "Regulation of placental metabolism by glucose supply." Reproduction, Fertility and Development 7, no. 3 (1995): 365. http://dx.doi.org/10.1071/rd9950365.

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Glucose is supplied to the placenta and fetus from the maternal plasma according to concentration-dependent mechanisms exhibiting saturation kinetics that are mediated by facilitative transporter proteins on both the maternal-facing microvillus and fetal-facing basal trophoblast membranes. Placental glucose transport to the fetus requires a net maternal-to-fetal plasma glucose concentration gradient that is determined by placental as well as fetal glucose consumption. Fetal plasma glucose concentration, independent of maternal glucose concentration, regulates the partition of placental glucose

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Wawrzykowski, Jacek, Monika Jamioł, and Marta Kankofer. "The Significance of Selected Collagens and Their Connection with Relevant Extracellular Matrix Proteins in Bovine Early-Mid-Pregnancy and Parturition with and Without Retained Foetal Membranes." Biomolecules 15, no. 2 (2025): 167. https://doi.org/10.3390/biom15020167.

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Appropriate placental structure and function assure foetal development, delivery of nutrients, and removal of waste. Collagens, as structural proteins, are crucial for the maintenance of placental growth and function. The aim of this study was to describe the profile of collagen 1 and 4 in the placental tissues of cows and to correlate it to previously described activities of collagenases and adhesive proteins. Placental samples were collected from pregnant cows in the slaughterhouse (2nd, 4th, and 6th month; n = 12) and during parturition after caesarean section. Samples taken during caesarea

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Helman, Sheridan L., Sarah J. Wilkins, Daniel R. McKeating, et al. "The Placental Ferroxidase Zyklopen Is Not Essential for Iron Transport to the Fetus in Mice." Journal of Nutrition 151, no. 9 (2021): 2541–50. http://dx.doi.org/10.1093/jn/nxab174.

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ABSTRACT Background The ferroxidase zyklopen (Zp) has been implicated in the placental transfer of iron to the fetus. However, the evidence for this is largely circumstantial. Objectives This study aimed to determine whether Zp is essential for placental iron transfer. Methods A model was established using 8- to 12-wk-old pregnant C57BL/6 mice on standard rodent chow in which Zp was knocked out in the fetus and fetal components of the placenta. Zp was also disrupted in the entire placenta using global Zp knockout mice. Inductively coupled plasma MS was used to measure total fetal iron, an indi

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St-Pierre, M. V., T. Stallmach, A. Freimoser Grundschober, et al. "Temporal expression profiles of organic anion transport proteins in placenta and fetal liver of the rat." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 287, no. 6 (2004): R1505—R1516. http://dx.doi.org/10.1152/ajpregu.00279.2003.

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Physiological cholestasis linked to immature hepatobiliary transport systems for organic anions occurs in rat and human neonates. In utero, the placenta facilitates vectorial transfer of certain fetal-derived solutes to the maternal circulation for elimination. We compared the ontogenesis of organic anion transporters in the placenta and the fetal liver of the rat to assess their relative abundance throughout gestation and to determine whether the placenta compensates for the late maturation of transporters in the developing liver. The mRNA of members of the organic anion transporting polypept

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Wang, Xiuyuan, Ruili Liu, Zhenpeng Chen, et al. "Combining Transcriptomics and Proteomics to Screen Candidate Genes Related to Bovine Birth Weight." Animals 14, no. 18 (2024): 2751. http://dx.doi.org/10.3390/ani14182751.

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The placenta is a vital organ in bovine reproduction, crucial for blood supply, nutrient transport, and embryonic development. It plays an essential role in the intrauterine growth of calves. However, the molecular mechanisms governing placental function in calves remain inadequately understood. Methods: We established transcriptome and proteome databases for low-birth-weight (LB) and high-birth-weight (HB) calf placentae, identifying key genes and proteins associated with birth weight through bioinformatics analyses that included functional enrichment and protein–protein interactions (PPIs).

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Antonson, Per, Gertrud U. Schuster, Ling Wang, et al. "Inactivation of the Nuclear Receptor Coactivator RAP250 in Mice Results in Placental Vascular Dysfunction." Molecular and Cellular Biology 23, no. 4 (2003): 1260–68. http://dx.doi.org/10.1128/mcb.23.4.1260-1268.2003.

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ABSTRACT Coactivators constitute a diverse group of proteins that are essential for optimal transcriptional activity of nuclear receptors. In the past few years many coactivators have been identified but it is still unclear whether these proteins interact indiscriminately with all nuclear receptors and whether there is some redundancy in their functions. We have previously cloned and characterized RAP250 (ASC-2/PRIP/TRBP/NRC), an LXXLL-containing coactivator for nuclear receptors. In order to study its biological role, Rap250 null mice were generated by gene targeting. Here we show that geneti

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Yang, H., and E. B. Jeung. "99 THE DIFFERENTIAL EXPRESSION OF CALCIUM-RELATED PROTEINS BY HYPOXIC STRESS IN THE DUODENUM, KIDNEY, AND PLACENTA OF PREGNANT RATS." Reproduction, Fertility and Development 25, no. 1 (2013): 197. http://dx.doi.org/10.1071/rdv25n1ab99.

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Preeclampsia is a pregnancy-specific disease characterized by the de novo development of concurrent hypertension, proteinuria, and oxidative stress in placenta. Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. Oxidative stress, resulting from deficient remodeling of spiral arteries, is an important inducer of preeclampsia. The potassium-dependent sodium/calcium exchangers including NCKX3 and NCX1 play critical roles in the transport of intracellular calcium that is exchanged with extracellular sodium ions. Calcium-relate

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