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Dissertations / Theses on the topic 'Placenta; transporter; transportér'

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Published: 28 June 2021
Last updated: 29 July 2025

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1

Russi, Rachel Mary. "The molecular regulation of placental zinc transporters." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.402646.

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2

Peres, Kenya Costa [UNESP]. "Transporte placentário via cavéola na placenta de bovinos clonados e transgênicos." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/115903.

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Made available in DSpace on 2015-03-03T11:52:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-02-26Bitstream added on 2015-03-03T12:06:08Z : No. of bitstreams: 1 000809964.pdf: 1108463 bytes, checksum: 43fa89dc624ca99b382ecaa200b42518 (MD5)<br>A utilização da transgenia com a proteína fluorescente verde (GFP) como marcador de células de origem fetal nas placentas de clones bovinos servirá de modelo inédito para estudo morfofisiológico e imunológico da interação materno-fetal, visto que possibilitará o seu mapeamento, diferenciando as células fetais das maternas. Tal modelo terá apli
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Peres, Kenya Costa. "Transporte placentário via cavéola na placenta de bovinos clonados e transgênicos/." Dracena, 2014. http://hdl.handle.net/11449/115903.

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Orientador: Flavia Thomaz Verechia Pereira<br>Banca: Cristiana Andrighetto<br>Banca: Vanessa Gomes Ueno<br>Resumo: A utilização da transgenia com a proteína fluorescente verde (GFP) como marcador de células de origem fetal nas placentas de clones bovinos servirá de modelo inédito para estudo morfofisiológico e imunológico da interação materno-fetal, visto que possibilitará o seu mapeamento, diferenciando as células fetais das maternas. Tal modelo terá aplicação direta, principalmente porque estes são animais que apresentam problemas em relação ao seu desenvolvimento. Com o auxílio deste modelo
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4

Evseenko, Denis. "Regulation and functional significance of ATP binding cassette transporters in human placenta." Thesis, University of Auckland, 2008. http://hdl.handle.net/2292/2348.

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The aim of this project was to study ATP binding cassette (ABC) transporters in the human placenta, in particular their regulation and role in trophoblast differentiation and survival. The presence and localisation of four major placental drug transporters, multidrug resistance gene product 1 and 3 (MDR1 and 3)/ABC subfamily B members 1 and 4 (ABCB1 and 4), multidrug resistance associated proteins 1 and 2 (MRP1 and 2)/ABCC1 and 2 and breast cancer resistance protein (BCRP)/ABCG2 was initially studied in term human placenta, cultured primary trophoblast and BeWo and Jar trophoblast-like cell li
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5

Hirst, Chloe. "Placental taurine transport in pre-eclampsia." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/placental-taurine-transport-in-preeclampsia(85a6b6e1-f0be-46f4-bec4-22c03183ff19).html.

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Pre-eclampsia (PE) is a serious disease affecting approximately 5% of pregnancies per annum. The disease etiology is complex but its origin lies in abnormal placental development and function. PE is associated with inflammation, increased nitrative stress and abnormal renewal of syncytiotrophoblast (STB), the transporting epithelium of the placenta. STB is renewed by cytotrophoblasts (CTBs) that proliferate, differentiate and fuse with STB and this is balanced by apoptosis. The amino acid taurine facilitates proliferation, differentiation and apoptosis in non-placental tissues. Taurine is also
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6

Taylor, Louise. "Comparative analyses of ABC transporters and metabolising enzymes in human and rat placental models." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/comparative-analyses-of-abc-transporters-and-metabolising-enzymes-in-human-and-rat-placental-models(3daff296-0364-4e4b-89f8-337dac6dbf10).html.

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The placenta provides a protective barrier for the developing foetus during gestation. Physiological barriers including the placenta, liver, kidney, intestine and blood-brain barrier are known to express ATP-Binding cassette transporters (ABC transporters) and metabolising enzymes. These specialised proteins have the ability to transport or metabolise xenobiotics. There is evidence to suggest that ABC transporters and metabolising enzymes are located at the interface between the maternal and foetal blood supplies (a cell layer referred to as the syncytiotrophoblast) and therefore may help prot
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7

Wang, Meng. "Enhancement of the Placental Transmission of Lopinavir Using a Transporter Targeted Prodrug Strategy." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3973.

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Lopinavir (LPV) is a potent protease inhibitor specific for HIV-1. However, LPV has poor placental penetration due to substrate activity for efflux transporter by P-glycoprotein (P-gp). Since fatty acid transporters are highly expressed in the placenta during pregnancy, we designed fatty acid ester prodrug of lopinavir as substrates of fatty acid transporter in order to improve their uptake into placenta. Seven dicarboxylic acid esters of lopinavir have been made in our lab. The structures were characterized by 1H-NMR, 13C-NMR, LC-MS/MS, HRMS, IR and melting points. After making the prodrugs,
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8

Jobarteh, Modou Lamin. "The effect of prenatal nutritional intervention on placental nutrient transporter expression and feto-placental outcome in rural Gambian women." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225784.

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Iron and zinc deficiency during pregnancy is common among women in low-income nations. In such settings, prenatal nutritional intervention is encouraged to improve pregnancy outcome. The impact of the intervention on transporter proteins involved in fetal nutrient supply is unexplored. This study investigated gene expression of some transporter proteins involved in fetal nutrient supply in the placenta. In a trial in rural Gambia, pregnant women at <20weeks of gestation were randomised to 4 nutritional intervention arms: i) Iron and folic acid (FeFol), representing the usual care ii) Multiple
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9

Sivaprasadarao, A. "Studies on the transport and uptake of vitamin A by placenta." Thesis, University of Leeds, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384722.

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10

Vasilopoulou, Elisavet. "The role of thyroid hormones in placental development and the importance of the thyroid hormone transporter MCT8." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1146/.

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Thyroid hormones (THs) are important for fetoplacental development. Human intrauterine growth restriction (IUGR) is associated with malplacentation and reduced fetal circulating concentration of THs. The expression of the plasma membrane TH transporters MCT8, MCT10, LAT1, LAT2, OATP1A2 and OATP4A1 was characterised in human placental biopsies across gestation. The protein expression of MCT8 was increased in samples from severe IUGR compared with normal pregnancies. In vitro, triiodothyronine (T\(_3\)) decreased survival and increased apoptosis of IUGR compared with normal cytotrophoblasts, whi
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11

Robertson, Dylan. "Hydrocortisone and TGF-ß1 regulate the glucocorticoid receptor and the serotonin transporter in SWAN-71 and JEG-3 cells." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/386033.

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Introduction Pregnancy-related disorders such as pre-eclampsia (PE), intrauterine growth restriction (IUGR), and pre-term birth (PTB) significantly contribute to maternal and fetal morbidity and mortality in all human societies. Each of these conditions can result from placental insufficiency, a pathophysiological condition affecting the placenta due to trophoblast dysfunction. Maternal complications during pregnancy such as gestational diabetes mellitus (GDM) and perinatal depression (PD) show significant associations with these placental pathologies. Perturbations in stress and inflammatory
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Brett, Kendra Elizabeth. "Maternal Phenotype, Directly Measured Physical Activity and Associations with Placenta Nutrient Transport Related Gene Expression." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32514.

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The intrauterine environment plays an important role in fetal development and downstream health. Given the rise in maternal obesity and the incidence of babies being born large-for-gestational-age, research is needed exploring the mechanisms through which maternal obesity and health behaviours affect the delivery of nutrients to the fetus. This thesis includes three manuscripts in the pursuit of two objectives: 1) To determine whether there are changes in placenta nutrient transport-related gene expression in response to obesity, excess gestational weight gain, and variations physical activity
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13

Carey, Erica Ashton Kayleigh. "AMP-Activated Protein Kinase Knockdown in Labyrinthine Trophoblast Cells Results in Altered Morphology and Function." Wright State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=wright1377417590.

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14

Hutchinson, Kelly Ann. "Assessing the Effect of Exercise During Pregnancy on Myokine Response and Placental Growth and Function In Vitro." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39808.

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Background: It is well established throughout the literature that regularly engaging in physical activity throughout pregnancy is associated with optimized health outcomes for both the mother and the fetus. The mediators and mechanistic pathways through which these observed exercise-induced outcomes are achieved are largely unknown. This thesis attempts to address this gap in knowledge. Methods: The objective of the first study was to develop an exercise protocol based on the recommendations from the ‘2019 Canadian guideline for physical activity throughout pregnancy’ and to subsequently eval
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15

Crouse, Matthew Scott Pennell. "Effects of Maternal Nutrition on Fructose, Glucose, and Cationic Amino Acid Transporter Expression in Bovine Utero-Placental Tissues from Days 16 to 50 of Gestation." Thesis, North Dakota State University, 2016. https://hdl.handle.net/10365/28240.

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Poor Maternal nutrition has been implicated to reduce nutrient transport to the conceptus. Therefore, we hypothesized that maternal nutrition and day of gestation would impact mRNA expression of nutrient transporters GLUT1, GLUT3, GLUT5, GLUT14, CAT-1, CAT-2, and CAT-3 in beef heifers. Crossbred Angus heifers (n = 49) were bred via AI, assigned to nutritional treatment (CON = 100% of requirements for 0.45 kg/d gain and RES = 60% of CON) and ovariohysterectomized on d 16, 34, or 50 of gestation. Expression of CAT-2 was the only gene in any tissue to demonstrate a day × treatment interaction. Ex
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16

Berveiller, Paul. "Cancer du sein pendant la grossesse : interactions des taxanes avec le trophoblaste humain par une approche ex vivo et in vitro." Thesis, Paris 5, 2014. http://www.theses.fr/2014PA05T029/document.

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La survenue d’un cancer du sein découvert durant la grossesse est un événement dramatique compliquant entre 1/3000 et 1/10000 grossesses, ce qui en fait le cancer le plus fréquemment rencontré chez la femme enceinte. Sur le plan thérapeutique, certaines molécules anticancéreuses peuvent être utilisées, notamment les taxanes (paclitaxel et docétaxel). Si les études cliniques rétrospectives isolées semblent plutôt rassurantes, les données concernant leur passage transplacentaire sont encore fragmentaires. Quant à leurs effets sur le placenta humain et plus particulièrement sur la fonction de tra
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17

Ferré, Dolcet Lluis. "Expression of cellular transporters of water and monosaccharides in the uterus and the placental transference zone in different gestational and non-gestational phases in the queen." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400409.

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La placenta está considerada como el órgano principal encargado del transporte de solutos y nutrientes entre madre y feto. Por su característica función, durante la gestación, tanto el útero como la placenta sufren diversos cambios estructurales para la preparación del endometrio para la futura implantación y desarrollo fetal. El balance hidrológico y el metabolismo glucídico son mecanismos esenciales para la preparación del epitelio y del estroma para la implantación del embrión, estando también involucrados en el desarrollo fetal proporcionando una correcta nutrición al feto en desarr
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SCHMID, KARA E. "ENDOGENOUS AND EXOGENOUS SOURCES OF CHOLESTEROL DURING FETAL DEVELOPMENT." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1061304521.

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19

Daoud, Georges. "Implication des protéines cytoplasmiques liant les acides gras dans le transport de l'acide linoléique et identification des mécanismes impliqués dans la différenciation des cellules placentaires humaines /." Montréal : Université du Québec à Montréal, 2006. http://accesbib.uqam.ca/cgi-bin/bduqam/transit.pl?&noMan=24634896.

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20

Osiecki, Michael J. "Isolation and expansion of placental derived mesenchymal stromal cells in a packed bed bioreactor." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/97947/1/Michael_Osiecki_Thesis.pdf.

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Mesenchymal stromal cells (MSCs) are thought to be useful in wound healing applications, but are not available from human sources in large enough quantities to be clinically viable. To isolate and expand placental derived human MSCs, this project details the design and scale up of a novel packed bed bioreactor that decouples the oxygen supply from the bulk medium flow by allowing oxygen to diffuse through the reactor wall. The design was further optimised through finite element modelling to expand up to 3x10^8 MSCs. In addition, modelling provided insight into the reduced cellular growth rate
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21

Rigourd-Rey, Virginie. "Evaluation de l'implication du gène STOX1 dans la pathologie placentaire." Paris 11, 2010. http://www.theses.fr/2010PA11T007.

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La PE est définie par une hypertension significative apparaissant au-delà de 20 semaines de grossesse associée à une protéinurie. C'est une pathologie fréquente (5-10% des grossesses) responsable d'une forte morbidité et mortalité materno-fœtale (éclampsie, hématome rétro-placentaire, prématurité induite, RCIU. . . ). La physiopathologie de la PE reste mal connue. Récemment, par clonage positionnel, le premier gène de prédisposition à la PE, STOX1 en 10q22 a été identifié. Le but de ce travail est d'évaluer le rôle de STOX1 et de ses cibles moléculaires dans la cascade complexe de la physiopat
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22

Lagrange, Fabrice. "Influence de la stéréosélectivité des antiinflammatoires non stéroi͏̈diens sur leur passage transplacentaire et leur distribution articulaire : application au kétoprofène." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28777.

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23

Kučerová, Veronika. "Hodnocení exprese vybraných ABC transportérů v placentě." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446181.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Veronika Kučerová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Consultant: PharmDr. Lenka Ťupová, Ph.D. Title of diploma thesis: Study on expression of selected ABC transporters in placenta The placenta is a temporary organ through which the fetus is supplied with nutrients and oxygen from the mother's blood and conversely waste substances are transferred into the mother's blood during pregnancy. Substance transfer through the placenta is a complex process controlled by a number of p
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Dudičová, Simona. "Vliv stimulace placentárních buněk in vitro a ex vivo na expresi vybraných ABC a OATP transportérů." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-437879.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Simona Dudičová Supervisor: Assoc. Prof. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: The effect of in vitro and ex vivo placental cells stimulation on expression of selected ABC and OATP transporters The placenta is an organ that plays a key role throughout pregnancy for proper fetal development. One of the important functions provided by the placenta is the transport of substances between the mother and the fetus. This transfer of substances enabled mainly by membrane transpo
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Michalská, Martina. "Exprese vybraných membránových transportérů v placentách těhotných žen s diagnostikovanou předčasnou rupturou plodových obalů." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397867.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Martina Michalská Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Expression of selected membrane transporters in placentas of pregnant women diagnosed for preterm rupture of membranes Placenta is a key organ for pregnancy maintenance. One of its main functions is transport of compounds between mother and her fetus. The transplacental penetration is ensured due to membrane transporters that are present in the apical or basal side of trophoblast. Their expression l
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Umanová, Barbora. "Exprese a funkce placentárních lékových transportérů ve zdraví a nemoci." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-411912.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Barbora Umanová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Expression and function of placental drug transporters in health and disease There are many physiological changes during pregnancy. Placenta is a crucial organ which mediates exchange of nutrients, metabolites and respiratory gases, provides endocrine functions and fetal protection. A pregnant woman and her fetus may be exposed to various potentially harmful substances during pregnancy, including dr
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Ťupová, Lenka. "Interakce vybraných antiretrovirálních léčiv a metylrtuti s membránovými transportéry placenty." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-436154.

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Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lenka Ťupová Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of doctoral thesis: Interactions of selected antiretroviral drugs and methylmercury with placental membrane transporters. Pregnant women are especially in developed countries exposed to high amount of various xenobiotic including environmental pollutants and drugs. Antiretroviral therapy (ART) is administered to HIV positive pregnant women for the purpose of prevention of HIV mother- to-child-transmission. Pharma
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28

Currie, Margaret J. (Margaret Jane). "Regulation of glucose transporters in sheep placenta." 2001. http://hdl.handle.net/2292/3090.

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Transplacental glucose transport is vital to fetal growth. Although the presence of glucose transporter-1 (GLUT1) and GLUT3 has been demonstrated in mammalian placenta, the factors regulating these genes remain unclear. Therefore, the overall aim of these studies was to clone ovine GLUT1 (oGLUT1) and oGLUT3 cDNAs, and to use these to investigate gene expression during ovine placental development and function. Ovine GLUT1 (~2.2 kb) and oGLUT3 (483 bp) cDNAs were isolated and cloned. Sequence analysis demonstrated that oGLUT1 showed high homology (97 - 99%) with other mammalian species, whereas
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Dvořáková, Marie. "MRP transportní proteiny v placentě." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-292542.

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The MRP mebrane proteins, which belong to the ABC transporter family, comprise currently 9 members. The MRP transport proteins are expressed in various tissues of the organism, including placenta. The major physiological role of the multidrug transporters is the transport of many endogenous and exogenous compounds, including drugs, across the cell membrane. This thesis summarizes up to date information concerning expression and function MRP transporters in placenta a and in other tisssues in organism. Only five MRP transporters have been detected in placenta, namely MRP1, MRP2, MRP3, MRP5 a MR
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Matiašková, Zuzana. "Role vybraných ABC a SLC transportérů v přestupu maraviroku přes buněčné membrány: vliv na transport v placentě." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397868.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and toxikology Student: Zuzana Matiašková Supervisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Role of selected ABC and SLC transporters in transmembrane permeability of maraviroc: effect on transport in placenta Antiretroviral drug maraviroc is an inhibitor of CCR5-trophic HIV virus and belongs to the group of entry inhibitors. Nowadays, maraviroc is administered as part of combination antiretroviral therapy (cART) primarily in adults, children over the age of two and pregnant women to red
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Lalinská, Anežka. "Studium interakcí antiretroviálního léčiva tenofoviru a jeho proléčiva tenofoviru disoproxil fumarátu s placentárními nukleosidovými transportéry." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-382786.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Anežka Lalinská Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Study of interactions of antiretroviral drug tenofovir and its prodrug tenofovir disoproxil fumarate with placental nucleoside transporters Tenofovir (TFV) in the form of ester prodrug tenofovir disoproxil fumarate (TDF) is an essential part of combination antiretroviral therapy. It is often used in the prevention of perinatal HIV transmission. However, precise mechanism(s) involved in transfer of TFV/TDF fr
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Křečková, Veronika. "Role lékových transportérů v placentárním přestupu entekaviru." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397928.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Veronika Křečková Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Role of drug transporters in placental transfer of entecavir Entecavir (ETV), an analogue of guanosine, is a highly efficient anti-hepatitis B antiviral drug. It is the first-line therapy for both adults and children. Its use in pregnancy is limited due to a number of factors, including lack of data on placental pharmacokinetics. The placental transition of drugs is frequently controlled by drug transporte
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Jirásková, Lucie. "Interakce membránových transportérů s léčivy v placentě a duktálním adenokarcinomu pankreatu." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-415556.

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Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Mgr. Lucie Jirásková Supervisor: doc. PharmDr. Lukáš Červený, Ph.D. Title of doctoral thesis: Interactions of membrane transporters with drugs in the placenta and pancreatic ductal adenocarcinoma Membrane transporters are found throughout the body, where they are responsible for many vital functions. Important representatives of membrane transporters are P-glycoprotein (ABCB1), Breast cancer resistance protein (ABCG2) and multidrug resistance-associated protein 2 (ABCC2) belonging to
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Wu, Jing-Shan, and 吳菁山. "Effects of phenobarbital on human placental glucose transporters type I and type III." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/42617912076741821162.

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碩士<br>國立臺灣大學<br>藥學研究所<br>95<br>The sodium-independent facilitated glucose transporters, GLUT1 and GLUT3, are expressed in placental tissues and are responsible for glucose transfer from maternal to the fetus. Deficiency in glucose levels may cause detrimental effects on fetal growth and development. It was reported that phenobarbital can be related to occurrence of intrauterine growth retardation (IUGR). Although phenobarbital is known to be an indirect activator of CAR, an orphan nuclear receptor, the interaction between phenobarbital and placental glucose transporters is far from clear. To i
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"Expression of divalent metal transporter 1 (DMT-1) in human placenta and fetal tissues of early pregnancy." 2003. http://library.cuhk.edu.hk/record=b5891564.

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Kwan Pui-Chun.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 140-155).<br>Abstracts in English and Chinese.<br>Chapter Chapter 1 --- Introduction<br>Chapter 1.1 --- Overview --- p.1<br>Chapter 1.2 --- Iron homeostasis --- p.5<br>Chapter 1.3 --- Natural Resistance Associated Marcophage Protein (Nramp) Family --- p.15<br>Chapter 1.4 --- Divalent Metal Transporter 1 (DMT1) --- p.18<br>Chapter 1.5 --- Iron Responsive Element (IRE) and Iron Regulatory Protein (IRP) --- p.23<br>Chapter 1.6 --- Expression and localization of DMT-1 in h
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36

Shearman, Lauren Patricia. "Cocaine-sensitive monoamine transporters in rat placenta labeled with (iodine-125)RTI-55 and tritiated nisoxetine." 1996. https://scholarworks.umass.edu/dissertations/AAI9619437.

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Some of the adverse effects of prenatal cocaine exposure have been associated with uteroplacental vasculature, and (3H) cocaine binding sites were previously reported in human placental villus tissue (Ahmed et al., 1990). Specific uptake systems for serotonin (5-HT) and norepinephrine (NE) are present in human placental syncytiotrophoblastic cells and may be substrates for cocaine action (Cool et al.. 1990; Ramamoorthy et al., 1993b). To investigate whether monoamine transporters are present in rat placenta, I studied the characteristics of placental cocaine recognition sites, and the influenc
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Lamparelli, Rosario D. V. "Ferritin as an iron transport protein ferritin uptake and iron ultilisation by guinea pig placenta." Thesis, 1990. https://hdl.handle.net/10539/24785.

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A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg in fulfilment of the Degree of Master of Science in the branch of Medicine<br>The guinea pig clears circulating tissue ferritin in a manner different from other mammals. Previous work in man and in rats has shown that injected tissue ferritin is removed from the plasma predominantly by the liver; however, in the guinea pig it is cleared predominantly by red cell precursors and furthermore, the ferritin iron is utilised directly for haem synthesis. During pregnancy, the foeto-placental complex als
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Pollex, Erika. "Fetal Exposure to Antidiabetic Drugs: The Role of the Placenta." Thesis, 2010. http://hdl.handle.net/1807/24857.

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Gestational diabetes, a common medical complication in pregnancy, may lead to severe fetal consequences if left untreated. A major concern with the use of antidiabetic drugs in pregnancy is the potential for placental transfer and fetal toxicity. The presence of endocytic pathways and several ABC transporter proteins has been demonstrated in the human placenta and are believed to play an important role in determining fetal exposure to drugs used in pregnancy. The objective of this thesis is to investigate the safety and transfer of the oral hypoglycemic agent, glyburide, and the new long ac
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39

Marková, Eliška. "Hodnocení vlivu vybraných nových antiretrovirálních léčiv na transport karnitinu v placentě." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397846.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Eliška Marková Suprevisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta Nowadays, the antiretroviral treatment of HIV-positive pregnant women is the standard approach for restriction of transmission of HIV infection from mother to the fetus. In spite of necessity of this pharmacotherapy, it is important to know its safety and risks. For the correct fetal development and function of pla
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40

Riols, Mathilde. "Étude de l'effet d'un antagoniste se liant au récepteur à la PTHRP (PTH1R) sur les niveaux d'expression d'ARNm de protéines intervenant dans le transport de calcium via le placenta humain." Mémoire, 2008. http://www.archipel.uqam.ca/1358/1/M10444.pdf.

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Durant la grossesse, 30 g de calcium de la mère vers le foetus sont transférés à travers le placenta à raison de 140 mg/Kg/jour pendant le troisième trimestre. Cet apport calcique est primordial au bon développement du foetus notamment dans la formation de ses os et ses dents. De plus, le calcium passant au travers du placenta provient à la fois de la diète maternelle et de la résorption des os maternels afin de subvenir convenablement aux besoins foetaux. Il est donc essentiel que la consommation de calcium par la mère soit suffisante, qu'il y ait une bonne efficacité du transport transplace
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41

Gravel, Ariane. "Étude du transport de l'acide linoléique dans le placenta humain : influences des profils lipidique et hormonal maternels ainsi que de l'indice de masse corporelle maternel." Mémoire, 2008. http://www.archipel.uqam.ca/1318/1/M10287.pdf.

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La prévalence accrue de surplus pondéral et d'obésité chez les femmes en âge de procréer est un problème de santé publique. De nombreuses études ont démontré qu'un poids maternel trop faible ou trop élevé peut influencer le poids du nouveau-né et ainsi influencer son état de santé actuelle et future. Durant la grossesse, l'accumulation de gras foetal survient au dernier tiers. La disponibilité des acides gras essentiels pour le foetus ne dépend pas seulement de l'apport maternel en acide gras mais aussi de la fonction placentaire elle-même ainsi que des changements et des adaptations physiolog
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42

Strachoňová, Šárka. "Studium regulace genové exprese nukleosidových transportérů v buněčné linii BeWo." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397841.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Šárka Strachoňová Supervisor: PharmDr. Lukáš Červený, Ph.D. Title of diploma thesis: Studium of gene regulation of nucleoside transporters in BeWo cell line Nucleoside transporters (NTs) localized in syncytiotrophoblast control placental uptake of nucleosides. Dysregulation of NTs can disrupt nucleoside homeostasis with a negative consequences on placental and fetal development and can lead to a change in placental pharmacokinetics of nucleoside-derived drugs. Therefore, understa
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Poudrier, Isabelle. "Effet du peptide apparenté à la parathormone sur la différenciation et le transport calcique des trophoblastes humains." Mémoire, 2010. http://www.archipel.uqam.ca/2914/1/M11358.pdf.

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Lors de la grossesse, différentes complications peuvent survenir et amener des conséquences néfastes sur la santé de la mère et du foetus. Par exemple, une malformation du placenta peut mener à des conditions pathologiques telles le retard de croissance intra-utérin ou la pré-éclampsie. Ces maladies semblent, respectivement, être causées par un désordre lors de la différenciation des cytotrophoblastes en syncytiotrophoblastes et une altération du transport de calcium de la mère au foetus. Il est donc essentiel de découvrir les mécanismes cellulaires et moléculaires qui régissent ces phénomènes
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44

Amyot, Marc. "Étude de l'influence d'un KO en PTHRP ou en PTH1R sur le niveau d'expression des protéines de manutention du calcium dans le placenta de souris." Mémoire, 2008. http://www.archipel.uqam.ca/1474/1/M10603.pdf.

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Le peptide apparenté à la parathormone (PTHrP) est un régulateur important du transport de calcium placentaire durant la gestation. Une concentration adéquate de calcium est requise afin d'assurer la croissance et le bon développement du foetus. Dans la présente étude, l'impact d'une délétion en PTHrP ou en son récepteur (PTH1R) a été mesuré dans le placenta de souris. L'usage d'un tel modèle animal a permis d'évaluer l'importance de la PTHrP dans le transport de calcium placentaire mais également les répercussions de telles délétions sur l'expression d'ARNm des protéines de manutention du cal
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