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Journal articles on the topic 'Placental alpha microglobulin-1 (PAMG-1)'

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Published: 4 June 2021

Last updated: 6 February 2022

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1

Fuchs, B. B., M. N. Boltovskaya, E. I. Zaraiskii, and S. V. Nazimova. "Monoclonal antibodies against placental alpha-1-microglobulin (PAMG-1)." International Journal of Immunopharmacology 13, no. 6 (1991): 793. http://dx.doi.org/10.1016/0192-0561(91)90350-g.

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2

Khvorostukhina, N. F., A. A. Plekhanov, D. A. Novichkov, A. V. Romanovskaya, and A. N. Ramazanova. "Endotoxicosis and placental dysfunction in pregnant women with acute pyelonephritis." Voprosy ginekologii, akušerstva i perinatologii 19, no. 6 (2020): 22–27. http://dx.doi.org/10.20953/1726-1678-2020-6-22-27.

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Objective. To assess the impact of endotoxicosis in pregnant women with acute pyelonephritis (AP) on the function of the utero-placental-fetal complex and gestational outcomes. Patients and methods. This study included 37 pregnant women with AP (Group 1) and 35 women with uncomplicated pregnancy (Group 2). Patients have undergone Doppler ultrasonography. In addition to that, we measured leukocyte intoxication index, total endotoxin, pregnancy-specific beta-1-glycoprotein (PSBG-1), and placental alpha microglobulin-1 (PAMG-1) in serum using enzyme-linked immunosorbent assay (ELISA). Results. AP

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3

Echebiri, Nelson C., Rachel G. Sinkey, Jamie L. Szczepanski, James A. Shelton, M. Maya McDoom, and Anthony O. Odibo. "Placental Alpha-Microglobulin-1 Test in Resource-Limited Settings." Obstetrics & Gynecology 127, no. 3 (2016): 584–91. http://dx.doi.org/10.1097/aog.0000000000001258.

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4

Echebiri, Nelson C., M. Maya McDoom, Meaghan Aalto, Jessica Pullen, and Nora M. Doyle. "Placental Alpha-Microglobulin-1 and Combined Traditional Diagnostic Test." Obstetrics & Gynecology 123 (May 2014): 3S. http://dx.doi.org/10.1097/01.aog.0000447245.31196.57.

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5

Ng, Beng Kwang, Pei Shan Lim, Mohamad Nasir Shafiee, et al. "Comparison between Amnisure Placental Alpha Microglobulin-1 Rapid Immunoassay and Standard Diagnostic Methods for Detection of Rupture of Membranes." BioMed Research International 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/587438.

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Objective. To determine the diagnostic accuracy of placental alpha microglobulin-1 assay and standard diagnostic methods for detecting rupture of membrane.Study Design. Prospective diagnostic study, between June 2011 to November 2011 at a tertiary centre. Initial evaluation included both the standard diagnostic methods for rupture of membranes and placental alpha microglobulin-1 immunoassay. The actual rupture of membranes was diagnosed on review of the medical records after delivery (absence of membrane or a positive pad chart).Main Outcome Measures. Placental alpha microglobulin-1 immunoassa

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6

Yildiz, C., H. Tanir, and T. Sener. "P411 Comparison of conventional methods (nitrazine test, ferning test) and placental alpha-microglobulin-1 (PAMG-1) in cervicovaginal discharge for the diagnosis of rupture of membranes." International Journal of Gynecology & Obstetrics 107 (October 2009): S530. http://dx.doi.org/10.1016/s0020-7292(09)61900-7.

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7

Farnsworth, Christopher, Erin E. Schuler, Alison Woodworth, Joely Straseski, E. Rebecca Pschirrer, and Robert D. Nerenz. "AACC Guidance Document on Laboratory Testing for the Assessment of Preterm Delivery." Journal of Applied Laboratory Medicine 6, no. 4 (2021): 1032–44. http://dx.doi.org/10.1093/jalm/jfab039.

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Abstract Identifying women with preterm labor who will go on to deliver prematurely is crucial to improving outcomes for mother and baby and for saving healthcare resources. Even among those with symptoms, the number of women who deliver preterm is low, and thus the low positive predictive value (PPV) and high negative predictive value (NPV) associated with available biomarkers does not substantially reduce the uncertainty of the clinical diagnosis. While there is some promise in the use of fetal fibronectin (fFN), interleukin 6 (IL-6), or placental alpha microglobulin 1 (PAMG-1) for predictin

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8

Agbara, JoyO, AdetokunboO Fabamwo, and YusufA Oshodi. "Diagnosis of foetal membrane ruptures: Placental alpha-microglobulin-1 to the rescue." Tropical Journal of Obstetrics and Gynaecology 34, no. 2 (2017): 85. http://dx.doi.org/10.4103/tjog.tjog_57_16.

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9

Echebiri, Nelson C., M. Maya McDoom, Jessica A. Pullen, Meaghan M. Aalto, Natasha N. Patel, and Nora M. Doyle. "Placental alpha-microglobulin-1 and combined traditional diagnostic test: a cost-benefit analysis." American Journal of Obstetrics and Gynecology 212, no. 1 (2015): 77.e1–77.e10. http://dx.doi.org/10.1016/j.ajog.2014.07.028.

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10

Bolotsky, Vyacheslav Mihailovich, Vera Yur'evna Zakharova, and Tat'yana Ul'yanovna Kuzminykh. "The AmniSure® ROM test in obstetric management: clinical aspects and economic analysis." Journal of obstetrics and women's diseases 61, no. 4 (2012): 33–39. http://dx.doi.org/10.17816/jowd61433-39.

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The detection of placental alpha-microglobulin-1 in cervicovaginal fluid, as a method to diagnose premature rupture of the fetal membranes, shows high sensitivity and specificity, has economic benefit and can be used in outpatient departments

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11

Lee, Si Eun, Joong Shin Park, Errol R. Norwitz, Kun Woo Kim, Hyun Soo Park, and Jong Kwan Jun. "Measurement of Placental Alpha-Microglobulin-1 in Cervicovaginal Discharge to Diagnose Rupture of Membranes." Obstetrics & Gynecology 109, no. 3 (2007): 634–40. http://dx.doi.org/10.1097/01.aog.0000252706.46734.0a.

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12

Phupong, Vorapong, and Vatinee Sonthirathi. "Retracted: Placental alpha-microglobulin-1 rapid immunoassay for detection of premature rupture of membranes." Journal of Obstetrics and Gynaecology Research 38, no. 1 (2011): 226–30. http://dx.doi.org/10.1111/j.1447-0756.2011.01688.x.

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13

Abdelazim, IbrahimA, MohammedM Al-Sherbeeny, MohamedE M. Ibrahim, AhmedA Fahmy, NohaH Rabei, and AmrA Aziz Khalifa. "Insulin-like growth factor binding Protein-1/alpha-fetoprotein versus placental alpha microglobulin-1 for diagnosis of premature fetal membranes rupture." Acta Medica International 3, no. 1 (2016): 69. http://dx.doi.org/10.5530/ami.2016.1.15.

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14

Adebara, Idowu O., Damilola Ifarinola, Olumide Adewara, et al. "A Comparison of Placental Alpha Microglobuliun-1 Rapid Immunoassay and Standard Clinical Method For Diagnosis of Premature Rupture of Membranes." International Journal of Maternal and Child Health and AIDS (IJMA) 8, no. 2 (2019): 156–62. http://dx.doi.org/10.21106/ijma.325.

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Background/Objective: Premature rupture of membranes (PROM) poses significant risk to the wellbeing of a pregnant woman and her fetus; the risk is more when not appropriately diagnosed and managed. The search for accuracy and increased specificity in diagnosis of PROM is an on-going process. The purpose of this study was to determine the accuracy of placental alpha microglobulin-1 (AmniSure ROM

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15

Wing, Deborah A., Sina Haeri, Angela C. Silber, et al. "Placental Alpha Microglobulin-1 Compared With Fetal Fibronectin to Predict Preterm Delivery in Symptomatic Women." Obstetrics & Gynecology 130, no. 6 (2017): 1183–91. http://dx.doi.org/10.1097/aog.0000000000002367.

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16

Kuhrt, Katy, Helena Watson, Paul Seed, and Andrew Shennan. "Placental Alpha Microglobulin-1 Compared With Fetal Fibronectin to Predict Preterm Delivery in Symptomatic Women." Obstetrics & Gynecology 131, no. 4 (2018): 743. http://dx.doi.org/10.1097/aog.0000000000002554.

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17

Heverhagen, Anneke, Marc Baumann, Luigi Raio, and Daniel Surbek. "128: Placental alpha-microglobulin-1 in combination with transvaginal ultrasound for prediction of preterm birth." American Journal of Obstetrics and Gynecology 212, no. 1 (2015): S81. http://dx.doi.org/10.1016/j.ajog.2014.10.174.

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18

Abdelazim, Ibrahim A., and Hanan H. Makhlouf. "Placental alpha microglobulin-1 (AmniSure® test) for detection of premature rupture of fetal membranes." Archives of Gynecology and Obstetrics 285, no. 4 (2011): 985–89. http://dx.doi.org/10.1007/s00404-011-2106-4.

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19

Eleje, George Uchenna, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, et al. "Diagnostic performance of placental alpha-microglobulin-1 test in women with prolonged pre-labour rupture of membranes." Journal of Maternal-Fetal & Neonatal Medicine 29, no. 8 (2015): 1291–96. http://dx.doi.org/10.3109/14767058.2015.1046375.

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20

Cousins, Larry M., Dorothy P. Smok, Stuart M. Lovett, and Deborah M. Poeltler. "AmniSure Placental Alpha Microglobulin-1 Rapid Immunoassay versus Standard Diagnostic Methods for Detection of Rupture of Membranes." American Journal of Perinatology 22, no. 06 (2005): 317–20. http://dx.doi.org/10.1055/s-2005-870896.

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21

Pollet-Villard, Marie, Régine Cartier, Pascal Gaucherand, and Muriel Doret. "Detection of Placental Alpha Microglobulin-1 versus Insulin-Like Growth Factor-Binding Protein-1 in Amniotic Fluid at Term: A Comparative Study." American Journal of Perinatology 28, no. 06 (2011): 489–94. http://dx.doi.org/10.1055/s-0030-1271215.

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22

Deshpande, Hemant, Umesh Sabale, C. S. Madkar, and Anuja Bobe. "A comparative study between placental alpha microglobulin-1 rapid immunoassay and standard diagnostic methods for detection of rupture of membranes." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 5 (2018): 1813. http://dx.doi.org/10.18203/2320-1770.ijrcog20181908.

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Background: To determine the efficacy of an immunoassay to measure levels of placental alpha-microglobulin-1 in cervico-vaginal secretions.Methods: 100 ANC cases admitted in Dr D. Y. Patil Hospital with symptoms of rupture of membranes during study period. Inclusion criteria-Pregnant women who presented with symptoms of ROM either in labour or not in labour, gestational age from 28 weeks onwards and who have given consent.Results: In 9 cases, the immunoassay test was negative, in 91 cases, it was positive and in one case, the liquor had a lot of meconium, the woman had to undergo an emergency

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23

Vischio, Anna T., Peter Kuhlmann, Laura Ross, Laura Ovittore, Salvador Sena, and Jessica Dodge. "AmniSure Placental Alpha Microglobulin-1 Rapid Immunoassay for Detection of Rupture of Membranes: A Comparison Study With Clinical-Based Testing." American Journal of Clinical Pathology 138, suppl 1 (2012): A024. http://dx.doi.org/10.1093/ajcp/138.suppl1.024.

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24

Abdelazim, Ibrahim A., and Hanan H. Makhlouf. "Placental alpha microglobulin-1 (AmniSure test) versus insulin-like growth factor binding protein-1 (Actim PROM test) for detection of premature rupture of fetal membranes." Journal of Obstetrics and Gynaecology Research 39, no. 6 (2013): 1129–36. http://dx.doi.org/10.1111/jog.12045.

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25

Borg, Hesham M., Mona Omar, and Ghada A. Suliman. "The Study of Vaginal Fluid Urea, Creatinine, B-HCG and Placental Alpha-1 Microglobulin in Diagnosis of Premature Rupture of Membranes." Open Journal of Obstetrics and Gynecology 09, no. 06 (2019): 811–26. http://dx.doi.org/10.4236/ojog.2019.96080.

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26

Abdelazim, Ibrahim A., Khaled M. Abdelrazak, Mohamed Al-kadi, Amr H. Yehia, and Amr F. Abdulkareem. "Fetal fibronectin (Quick Check fFN test) versus placental alpha microglobulin-1 (AmniSure test) for detection of premature rupture of fetal membranes." Archives of Gynecology and Obstetrics 290, no. 3 (2014): 457–64. http://dx.doi.org/10.1007/s00404-014-3225-5.

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27

Baev, Baev O. R., Tysyachnyi O. V. Tysyachnyi, Klimov V. A. Klimov, and Balashov I. S. Balashov. "Clinical and economic effectiveness of a placental alpha-microglobulin-1 test and that of the clinical diagnosis of premature rupture of membranes." Akusherstvo i ginekologiia 8_2019 (September 1, 2019): 71–76. http://dx.doi.org/10.18565/aig.2019.8.71-76.

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28

Sukchaya, K., and V. Phupong. "A comparative study of positive rate of placental alpha-microglobulin-1 test in pre-term pregnant women with and without uterine contraction." Journal of Obstetrics and Gynaecology 33, no. 6 (2013): 566–68. http://dx.doi.org/10.3109/01443615.2013.807786.

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29

Bolotskikh, Vyacheslav, and Vera Borisova. "Combined value of placental alpha microglobulin-1 detection and cervical length via transvaginal ultrasound in the diagnosis of preterm labor in symptomatic patients." Journal of Obstetrics and Gynaecology Research 43, no. 8 (2017): 1263–69. http://dx.doi.org/10.1111/jog.13366.

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30

Eleje, George Uchenna, Euzebus Chinonye Ezugwu, Dotun Ogunyemi, et al. "Accuracy and cost-analysis of placental alpha-microglobulin-1 test in the diagnosis of premature rupture of fetal membranes in resource-limited community settings." Journal of Obstetrics and Gynaecology Research 41, no. 1 (2014): 29–38. http://dx.doi.org/10.1111/jog.12475.

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31

Eleje, George Uchenna, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, et al. "Accuracy and response time of dual biomarker model of insulin-like growth factor binding protein-1/ alpha fetoprotein (Amnioquick duo+) in comparison to placental alpha-microglobulin-1 test in diagnosis of premature rupture of membranes." Journal of Obstetrics and Gynaecology Research 43, no. 5 (2017): 825–33. http://dx.doi.org/10.1111/jog.13296.

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32

Mittal, Pooja, Roberto Romero, Eleazar Soto, et al. "528: A role for placental alpha-microglobulin-1 in the identification of women with a sonographic short cervix at risk for spontaneous rupture of membranes." American Journal of Obstetrics and Gynecology 201, no. 6 (2009): S196—S197. http://dx.doi.org/10.1016/j.ajog.2009.10.694.

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33

Galletta, Marco A. K., Roberto E. Bittar, Agatha S. Rodrigues, Rossana P. V. Francisco, and Marcelo Zugaib. "Comparative analysis of Insulin‐like growth factor binding protein‐1, placental alpha‐microglobulin‐1, phenol and pH for the diagnosis of preterm premature rupture of membranes between 20 and 36 weeks." Journal of Obstetrics and Gynaecology Research 45, no. 8 (2019): 1448–57. http://dx.doi.org/10.1111/jog.13991.

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34

Lakhno, I. V., and S. V. Коrovay. "Actual issues of prediction and prevention of preterm birth." HEALTH OF WOMAN, no. 1(147) (March 5, 2020): 8–13. http://dx.doi.org/10.15574/hw.2020.147.8.

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Premature birth is a significant problem in modern medicine. The main aspects of its solution are the prediction and prevention of premature birth. Nowadays, among a large number of biophysical and biochemical markers of preterm birth, ultrasonic cevicometry is the most popular one. It is known that «short cervix syndrome» is not the equivalent of cervical insufficiency. The known strategies of preventive combinations are used in case of an increased risk of preterm birth. Therefore, the issue of developing a differentiated approach to the combined or separate use of progesterone, pessary, or

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35

Chawanpaiboon, Saifon, Vitaya Titapant та Julaporn Pooliam. "Placental α-microglobulin-1 in cervicovaginal fluid and cervical length to predict preterm birth by Thai women with symptoms of labor". Asian Biomedicine 15, № 3 (2021): 119–27. http://dx.doi.org/10.2478/abm-2021-0015.

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Abstract Background Presence of placental α microglobulin-1 (PAMG-1) in cervicovaginal fluid is a bedside test to predict preterm delivery. Objective To determine whether the accuracy of a positive PAMG-1 test result to predict preterm birth within 7 days and 14 days in our hospital setting can be improved by adding cervical length. Methods We recruited 180 pregnant women who attended the labor ward of Siriraj Hospital, Thailand, from 2016 to 2018 for this prospective observational study of diagnostic accuracy. We used data from 161 women who met inclusion criteria including symptoms of preter

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36

Petrenko, Ye, and K. P. Strubchevka. "Preterm labor: issues of prognosis, prevention and management (Literature rewiew)." Reproductive health of woman 3 (May 3, 2021): 57–64. http://dx.doi.org/10.30841/2708-8731.3.2021.234245.

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Preterm labor is the leading cause of neonatal mortality and the most common cause for antenatal hospitalization. Approximately 15 million babies are born preterm each year worldwide. Of those, one million babies die before the age of 5, which is 18% of all deaths of children at this age. 35% of early and late neonatal mortality (under 28 days of age) is associated with preterm birth.The pathophysiology of preterm labor includes at least four major pathogenetic mechanisms. The studied components of this process are premature activation of the maternal or fetal hypothalamic-pituitary-adrenal sy

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37

Amylidi-Mohr, Sofia, and Martin Mueller. "Frühgeburtsscreening: Was ist wirklich sinnvoll?" Praxis 108, no. 1 (2019): 53–57. http://dx.doi.org/10.1024/1661-8157/a003137.

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Zusammenfassung. Die spontane Frühgeburt ist ein Syndrom, das durch multiple Mechanismen ausgelöst wird. Angesichts der pathophysiologischen Heterogenität der Frühgeburt kann ein einzelner Biomarker nicht die geforderten hohen negativen und positiven Prädiktivwerte aufzeigen. Aus klinischer Sicht hat sich die Anamnese, sonografische Messung der Zervix-Länge und Test auf plazentares Alpha-Microglobulin-1 (PAMG-1) aus dem zervikovaginalen Sekret durchgesetzt. Weitere prospektive, gross angelegte longitudinale Studien müssen die kombinierte Verwendung neuer Biomarker validieren.

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38

Gude, NM, RG King, and SP Brennecke. "Endothelin: release by and potent constrictor effect on the fetal vessels of human perfused placental lobules." Reproduction, Fertility and Development 3, no. 4 (1991): 495. http://dx.doi.org/10.1071/rd9910495.

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Human placental lobules were bilaterally perfused with a modified Krebs solution at constant flow rates of 5 mL min-1, and fetal inflow perfusion pressure was recorded. The effect of infusions of endothelin-1 and endothelin-3 (ET-1 and ET-3) on the perfusion pressure was assessed and compared with that for the thromboxane A2-mimetic U46619 and prostaglandin F2 alpha (PGF2 alpha). All substances caused significant increases in pressure, ET-1 being the most potent, followed in order by U46619, ET-3 and PGF2 alpha. In addition, ET-like immunoreactivity was identified in the fetal effluent of plac

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39

Santipap, Monchai, and Vorapong Phupong. "Combination of three-dimensional ultrasound measurement of foetal adrenal gland enlargement and placental alpha microglobulin-1 for the prediction of the timing of delivery within seven days in women with threatened preterm labour and preterm labour." Journal of Obstetrics and Gynaecology 38, no. 8 (2018): 1054–59. http://dx.doi.org/10.1080/01443615.2018.1446422.

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40

Mikhaylin, Evgeny S., Gulrukhsor K. Tolibova, and Tatyana G. Tral. "Morfological and functional features of placentas in minor women." Journal of obstetrics and women's diseases 65, no. 5 (2016): 41–48. http://dx.doi.org/10.17816/jowd65541-48.

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Relevance. An in-depth study of the state of feto-placental complex, the characteristics of its reactions in response to hypoxia on the background of juvenile immaturity of minors can help to identify the main directions of the prevention of certain complications of pregnancy and childbirth among minors in the first place — placental insufficiency, preeclampsia, fetal hypoxia. Purpose of the study was to explore features of the histological structure of placentas and expression of HIF-1α and VEGF-A markers in placentas in minors.Materials and methods. 74 placentas from minors were investigated

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41

Tchirikov, Michael, Natalia Schlabritz-Loutsevitch, James Maher, et al. "Mid-trimester preterm premature rupture of membranes (PPROM): etiology, diagnosis, classification, international recommendations of treatment options and outcome." Journal of Perinatal Medicine 46, no. 5 (2018): 465–88. http://dx.doi.org/10.1515/jpm-2017-0027.

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AbstractMid-trimester preterm premature rupture of membranes (PPROM), defined as rupture of fetal membranes prior to 28 weeks of gestation, complicates approximately 0.4%–0.7% of all pregnancies. This condition is associated with a very high neonatal mortality rate as well as an increased risk of long- and short-term severe neonatal morbidity. The causes of the mid-trimester PPROM are multifactorial. Altered membrane morphology including marked swelling and disruption of the collagen network which is seen with PPROM can be triggered by bacterial products or/and pro-inflammatory cytokines. Acti

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42

Salas, S. P., R. F. Power, A. Singleton, J. Wharton, J. M. Polak, and J. Brown. "Heterogeneous binding sites for alpha-atrial natriuretic peptide in human umbilical cord and placenta." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 261, no. 3 (1991): R633—R638. http://dx.doi.org/10.1152/ajpregu.1991.261.3.r633.

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The distributions of atrial natriuretic peptide (ANP) clearance receptors in human umbilical cord and placenta were investigated by using des[Gln18,Ser19,Gly20,Leu21,Gly22]ANP-(4-2 3) (C-ANP) as a specific ligand of this receptor to displace bound alpha-125I-labeled ANP. alpha-125I-ANP bound reversibly to umbilical venous and arterial intima and to fetal placental and maternal decidual tissues, with dissociation constants of 1.24 +/- 0.51, 0.58 +/- 0.19, 1.86 +/- 0.51, and 1.07 +/- 0.25 mM, respectively. Binding was reversed by 1 microM unlabeled alpha-ANP but not by unrelated peptides such as

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43

Campbell, Robert A., Mark Cody, Yasuhiro Kosaka, Heather D. Campbell, and Christian Yost. "Placental HTRA1 Protease Cleaves Alpha-1-Antitrypsin and Generates Neonatal NET-Inhibitory Factor." Blood 132, Supplement 1 (2018): 273. http://dx.doi.org/10.1182/blood-2018-99-111195.

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Abstract BACKGROUND: Neutrophil extracellular traps (NET) are extracellular lattices of decondensed chromatin associated with anti-microbial proteins and degradative enzymes released by polymorphonuclear leukocytes (PMN) to trap and kill invading microbes. Dysregulated NET formation, however, contributes to inflammatory tissue damage. We have identified a novel NET-inhibitory peptide, neonatal NET-Inhibitory Factor (nNIF), present in the fetal circulation. nNIF is formed as a carboxy-terminus cleavage fragment of alpha-1 antitrypsin (AAT), an abundant, circulating protease inhibitor with homol

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44

Vijaya, S., M. Mahalakshmi, and I. Inbapriyanka. "Fetal haemoglobin and alpha 1 microglobulin as biochemical markers in predicting preeclampsia in late first trimester and early second trimester of pregnancy." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 8 (2018): 3226. http://dx.doi.org/10.18203/2320-1770.ijrcog20183322.

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Background: Preeclampsia is a multi system disorder with placenta as the organ of origin and maternal endothelium being the organ of target. According to recent studies, the cell free haemoglobin induces oxidative stress mediated damage to the blood placenta barrier with consequently elevated levels of HbF in maternal blood. Alpha 1 microglobulin is an endogenous protein with antioxidant property, present in elevated levels in maternal blood in response to oxidative stress. This fact forms the basis for our study. The objective of the present study was to establish association between high lev

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45

Wilhelm, S., H. Müller, V. Briese, T. Bittorf, J. Brock, and J. Heinig. "Determination of cytokine mRNA-expression in term human placenta of patients with gestational hypertension, intrauterine growth retardation and gestational diabetes mellitus using polymerase chain reaction." Zentralblatt für Gynäkologie 122, no. 08 (2000): 413–18. http://dx.doi.org/10.1055/s-2000-10606.

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Summary Objective: Our objective was to test the hypothesis, that pregnancy-related diseases are going along with changes in cytokine mRNA-expression at the placental site, either as a part of a pathological process or in connection with regulatory mechanisms induced by disturbances at the feto-maternal interface resulting from previous pathological changes – in the sense of counterregulation. Material and methods: The cytokines chosen for this investigation are known to 1.) be expressed in the human placental tissue, 2.) to be involved in immunological processes and 3.) the regulation of grow

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46

Yoshida, Kanoko, Kazuya Kusama, Yuta Fukushima, Takako Ohmaru-Nakanishi, Kiyoko Kato, and Kazuhiro Tamura. "Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts." International Journal of Molecular Sciences 22, no. 7 (2021): 3683. http://dx.doi.org/10.3390/ijms22073683.

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Alpha-1 antitrypsin (A1AT) is a glycoprotein that has been shown to protect tissues from proteolytic damage under various inflammatory conditions. Several studies show that A1AT may be associated with pre-eclampsia. However, the role of A1AT expression in placental physiology is not fully understood. In the present study, we aim to characterize the expression and function of placental A1AT. A1AT knockdown is found to reduce the expression of the serine protease HTRA1 in a trophoblast cell line. In addition, A1AT overexpression (A1AT-OE) increases the expression of HTRA1, IL6, CXCL8, and severa

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Karvas, Rowan M., Samuel McInturf, Jie Zhou, et al. "Use of a human embryonic stem cell model to discover GABRP, WFDC2, VTCN1 and ACTC1 as markers of early first trimester human trophoblast." Molecular Human Reproduction 26, no. 6 (2020): 425–40. http://dx.doi.org/10.1093/molehr/gaaa029.

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Abstract Human placental development during early pregnancy is poorly understood. Many conceptuses are lost at this stage. It is thought that preeclampsia, intrauterine growth restriction and other placental syndromes that manifest later in pregnancy may originate early in placentation. Thus, there is a need for models of early human placental development. Treating human embryonic stem cells (hESCs) with BMP4 (bone morphogenic protein 4) plus A83-01 (ACTIVIN/NODAL signaling inhibitor) and PD173074 (fibroblast growth factor 2 or FGF2 signaling inhibitor) (BAP conditions) induces differentiation

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48

Anggraini, Nutria Widya Purna, Sri Sulistyowati, Muhammad Adrianes Bachnas, Eric Edwin Yuliantara, Wisnu Prabowo, and Uki Retno Budihastuti. "Hypoxia Inducible Factor-1-Alpha Expression on Preeclampsia Mice Model With L-Arginine Administration." Folia Medica Indonesiana 57, no. 3 (2021): 226. http://dx.doi.org/10.20473/fmi.v57i3.22733.

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Preeclampsia is hypertension in pregnancy that aﬀects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. In the pathogenesis of preeclampsia, placental hypoxia plays an important role, associated with excessive trophoblast apoptosis resulting in decreased trophoblast and spiral arteries invasion. This placental hypoxic condition will induce increased expression of Hypoxia Inducible Factor -1-Alpha (HIF-1-A). L-Arginine is a potent vasodilator presumably to improve preeclampsia placental hypoxic conditions and reduce HIF-1-A expression. This

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Steger, D. J., J. H. Hecht, and P. L. Mellon. "GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland." Molecular and Cellular Biology 14, no. 8 (1994): 5592–602. http://dx.doi.org/10.1128/mcb.14.8.5592.

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The human glycoprotein hormone alpha-subunit gene is expressed in two quite dissimilar tissues, the placenta and anterior pituitary. Tissue-specific expression is determined by combinations of elements, some of which are common and others of which are specific to each tissue. In the placenta, a composite enhancer confers specific expression. It contains four protein-binding sites: two cyclic AMP (cAMP) response elements that bind CREB, a trophoblast-specific element that binds TSEB, and a sequence motif, AGATAA, that matches the consensus binding site for a family of transcription factors term

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50

Steger, D. J., J. H. Hecht, and P. L. Mellon. "GATA-binding proteins regulate the human gonadotropin alpha-subunit gene in the placenta and pituitary gland." Molecular and Cellular Biology 14, no. 8 (1994): 5592–602. http://dx.doi.org/10.1128/mcb.14.8.5592-5602.1994.

Full text

Abstract:

The human glycoprotein hormone alpha-subunit gene is expressed in two quite dissimilar tissues, the placenta and anterior pituitary. Tissue-specific expression is determined by combinations of elements, some of which are common and others of which are specific to each tissue. In the placenta, a composite enhancer confers specific expression. It contains four protein-binding sites: two cyclic AMP (cAMP) response elements that bind CREB, a trophoblast-specific element that binds TSEB, and a sequence motif, AGATAA, that matches the consensus binding site for a family of transcription factors term

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