Relevant bibliographies by topics / Plague, therapy

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Plague, therapy'

Author: Grafiati
Published: 12 December 2022
Last updated: 26 January 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Plague, therapy.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Plague, therapy"

1

Oyston, Petra CF, and E. Diane Williamson. "Prophylaxis and therapy of plague." Expert Review of Anti-infective Therapy 11, no. 8 (2013): 817–29. http://dx.doi.org/10.1586/14787210.2013.814432.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Sebbane, Florent, and Nadine Lemaître. "Antibiotic Therapy of Plague: A Review." Biomolecules 11, no. 5 (2021): 724. http://dx.doi.org/10.3390/biom11050724.

Full text
Abstract:
Plague—a deadly disease caused by the bacterium Yersinia pestis—is still an international public health concern. There are three main clinical forms: bubonic plague, septicemic plague, and pulmonary plague. In all three forms, the symptoms appear suddenly and progress very rapidly. Early antibiotic therapy is essential for countering the disease. Several classes of antibiotics (e.g., tetracyclines, fluoroquinolones, aminoglycosides, sulfonamides, chloramphenicol, rifamycin, and β-lactams) are active in vitro against the majority of Y. pestis strains and have demonstrated efficacy in various animal models. However, some discrepancies have been reported. Hence, health authorities have approved and recommended several drugs for prophylactic or curative use. Only monotherapy is currently recommended; combination therapy has not shown any benefits in preclinical studies or case reports. Concerns about the emergence of multidrug-resistant strains of Y. pestis have led to the development of new classes of antibiotics and other therapeutics (e.g., LpxC inhibitors, cationic peptides, antivirulence drugs, predatory bacteria, phages, immunotherapy, host-directed therapy, and nutritional immunity). It is difficult to know which of the currently available treatments or therapeutics in development will be most effective for a given form of plague. This is due to the lack of standardization in preclinical studies, conflicting data from case reports, and the small number of clinical trials performed to date.
APA, Harvard, Vancouver, ISO, and other styles
3

Cortopassi, Wilian A., Teodorico C. Ramalho, Carlos A. M. Fraga, Iris Mangas, Kamil Kuča, and Tanos C. C. França. "BUBONIC PLAGUE: HISTORICAL ASPECTS AND THERAPY." Military Medical Science Letters 84, no. 2 (2015): 67–75. http://dx.doi.org/10.31482/mmsl.2015.006.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Rosario-Acevedo, Raysa, Sergei S. Biryukov, Joel A. Bozue, and Christopher K. Cote. "Plague Prevention and Therapy: Perspectives on Current and Future Strategies." Biomedicines 9, no. 10 (2021): 1421. http://dx.doi.org/10.3390/biomedicines9101421.

Full text
Abstract:
Plague, caused by the bacterial pathogen Yersinia pestis, is a vector-borne disease that has caused millions of human deaths over several centuries. Presently, human plague infections continue throughout the world. Transmission from one host to another relies mainly on infected flea bites, which can cause enlarged lymph nodes called buboes, followed by septicemic dissemination of the pathogen. Additionally, droplet inhalation after close contact with infected mammals can result in primary pneumonic plague. Here, we review research advances in the areas of vaccines and therapeutics for plague in context of Y. pestis virulence factors and disease pathogenesis. Plague continues to be both a public health threat and a biodefense concern and we highlight research that is important for infection mitigation and disease treatment.
APA, Harvard, Vancouver, ISO, and other styles
5

Kugeler, Kiersten J., Paul S. Mead, Stefanie B. Campbell, and Christina A. Nelson. "Antimicrobial Treatment Patterns and Illness Outcome Among United States Patients With Plague, 1942–2018." Clinical Infectious Diseases 70, Supplement_1 (2020): S20—S26. http://dx.doi.org/10.1093/cid/ciz1227.

Full text
Abstract:
Abstract Background Plague is a rare and severe zoonotic illness with limited empiric evidence to support treatment recommendations. We summarize treatment information for all patients with plague in the United States (US) as collected under the auspices of public health surveillance. Methods We reviewed use of specific antimicrobials and illness outcome among cases of plague reported from 1942–2018. Antimicrobials were a priori classified into high-efficacy (aminoglycosides, tetracyclines, fluoroquinolones, sulfonamides, and chloramphenicol) and limited-efficacy classes (all others). Logistic regression models were created to describe associations between use of specific antimicrobial classes and illness outcome while controlling for potential confounding factors. Results Among 533 total reported plague cases during 1942–2018, 426 (80%) received high-efficacy antimicrobial therapy. Mortality differed significantly among those receiving high-efficacy therapy (9%) and only limited-efficacy therapy (51%). Aminoglycosides and tetracyclines were used more commonly than other classes, and their use was associated with increased odds of survival of plague. Gentamicin use was associated with higher mortality than streptomycin, and aminoglycoside use was linked to higher mortality than for tetracyclines. Fluoroquinolones have been used in treatment of >30% of patients in recent years and limited data suggest clinical effectiveness. Conclusions Most US patients with plague have received effective antimicrobials. Aminoglycosides and tetracyclines substantially improve survival of plague, and fluoroquinolones may be equally as effective, yet lack sufficient data. Early recognition and early treatment with any of these antimicrobial classes remain the most important steps to improving survival of plague.
APA, Harvard, Vancouver, ISO, and other styles
6

Bossi, P., A. Tegnell, A. Baka, et al. "Bichat guidelines for the clinical management of plague and bioterrorism-related plague." Eurosurveillance 9, no. 12 (2004): 23–24. http://dx.doi.org/10.2807/esm.09.12.00501-en.

Full text
Abstract:
Yersinia pestis appears to be a good candidate agent for a bioterrorist attack. The use of an aerosolised form of this agent could cause an explosive outbreak of primary plague pneumonia. The bacteria could be used also to infect the rodent population and then spread to humans. Most of the therapeutic guidelines suggest using gentamicin or streptomycin as first line therapy with ciprofloxacin as optional treatment. Persons who come in contact with patients with pneumonic plague should receive antibiotic prophylaxis with doxycycline or ciprofloxacin for 7 days. Prevention of human-to-human transmission via patients with plague pneumonia can be achieved by implementing standard isolation procedures until at least 4 days of antibiotic treatment have been administered. For the other clinical types of the disease, patients should be isolated for the first 48 hours after the initiation of treatment.
APA, Harvard, Vancouver, ISO, and other styles
7

Vagima, Yaron, David Gur, Moshe Aftalion, et al. "Phage Therapy Potentiates Second-Line Antibiotic Treatment against Pneumonic Plague." Viruses 14, no. 4 (2022): 688. http://dx.doi.org/10.3390/v14040688.

Full text
Abstract:
Plague pandemics and outbreaks have killed millions of people during the history of humankind. The disease, caused by the bacteria Yersinia pestis, is currently treated effectively with antibiotics. However, in the case of multidrug-resistant (MDR) bacteria, alternative treatments are required. Bacteriophage (phage) therapy has shown efficient antibacterial activity in various experimental animal models and in human patients infected with different MDR pathogens. Here, we evaluated the efficiency of фA1122 and PST phage therapy, alone or in combination with second-line antibiotics, using a well-established mouse model of pneumonic plague. Phage treatment significantly delayed mortality and limited bacterial proliferation in the lungs. However, the treatment did not prevent bacteremia, suggesting that phage efficiency may decrease in the circulation. Indeed, in vitro phage proliferation assays indicated that blood exerts inhibitory effects on lytic activity, which may be the major cause of treatment inefficiency. Combining phage therapy and second-line ceftriaxone treatment, which are individually insufficient, provided protection that led to the survival of all infected animals—a synergistic protective effect that represents a proof of concept for efficient combinatorial therapy in an emergency event of a plague outbreak involving MDR Y. pestis strains.
APA, Harvard, Vancouver, ISO, and other styles
8

Zalessky, V. N. "Photodynamic therapy of atherosclerotic plague: the porphyrin sensitizers application." European Journal of Pharmacology 183, no. 4 (1990): 1331. http://dx.doi.org/10.1016/0014-2999(90)94449-8.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Hill, Jim, Catherine Copse, Sophie Leary, Anthony J. Stagg, E. Diane Williamson, and Richard W. Titball. "Synergistic Protection of Mice against Plague with Monoclonal Antibodies Specific for the F1 and V Antigens of Yersinia pestis." Infection and Immunity 71, no. 4 (2003): 2234–38. http://dx.doi.org/10.1128/iai.71.4.2234-2238.2003.

Full text
Abstract:
ABSTRACT Monoclonal antibodies specific for Yersinia pestis V antigen and F1 antigen, administered singly or in combination, protected mice in models of bubonic and pneumonic plague. Antibodies showed synergy when administered prophylactically and as a therapy 48 h postinfection. Monoclonal antibodies therefore have potential as a treatment for plague.
APA, Harvard, Vancouver, ISO, and other styles
10

Hudson, Zoe. "Plagiarism: The plague of digital media?" Physical Therapy in Sport 11, no. 3 (2010): 73–74. http://dx.doi.org/10.1016/j.ptsp.2010.06.003.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Plague, therapy"

1

Alsaif, Aysha S. Y. A. S. "Treatment of dental plaque biofilms using photodynamic therapy." Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/18523/.

Full text
Abstract:
BACKGROUND: Photodynamic therapy (PDT) is a treatment modality involving a dye that is activated by exposure to light of a specific wavelength in the presence of oxygen to form oxygen species causing localised damage to microorganisms. AIM: To determine the most effective bactericidal incubation and irradiation times of erythrosine-based PDT, using a tungsten filament lamp, on in vivo- formed dental plaque biofilms. MATERIALS AND METHODS: The study was a two-phase randomised controlled study consisting of in-vitro and in-situ phases. Phase-1 aimed to determine the most appropriate incubation-time using erythrosine(220μM) based-PDT on lactobacillus species grown in-vitro. Phase-2 was conducted on 18-healthy adult participants wearing intraoral appliances with human enamel slabs to collect dental plaque samples in two separate periods for use in arm-1 and arm-2. For phase-2, accumulated dental plaque samples were tested under different experimental conditions; a) Control-1 (No erythrosine, no light); b) Control-2 (+Erythrosine, no light); c) Treatment-1 (+Erythrosine, +15min continuous light); d) Treatment-2 (+Erythrosine, +30sec light pulses for 5- times separated by 1min dark periods). Incubation-times of 15min and 2min were used in arm-1 and arm-2, respectively; as adapted from the previous pilot study and phase-1. Following treatment, percentage reduction of total bacterial counts were compared between the different groups. Additionally, Confocal Laser Scanning Microscopy(CLSM) was used to investigate the effect of PDT on in vivo-formed plaque biofilms. RESULTS: Significant reductions in the percentage of total bacterial counts (~93-95%) of in vivo-formed biofilms were found when using either 2min or 15min incubation-times and applying 15min continuous light. Whereas, when applying fractionated light, there was more cell death when 15min incubation-time was used (~91%) compared with the 2min incubation-time (~64%). CLSM results supported these findings. CONCLUSION: Improving the clinical usefulness of PDT by reducing its overall treatment time seems to be promising and effective in killing in vivo- formed dental plaque biofilms.
APA, Harvard, Vancouver, ISO, and other styles
2

Gong, Miranda Christina, and Miranda Christina Gong. "Strategies for a Novel Anti-Influenza Therapy." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/624996.

Full text
Abstract:
This experiment compares the implications of two methods of measuring viral particles, specifically Influenza particles in human cell lines in vitro. These strategies include plaque assays and xCELLigence screening. Plaque assays, also known as reduction assays, are plates that are overlaid with semi-solid medium that limits the spread of the virus and shows where each particle is located based on the "plaque" or empty space on the plates where cells have died and been removed. xCELLigence screening is a newer program that checks for "impedance", an artificial number that will measure the cells killed by virus as well as cell to cell interaction on a 96 well plate that utilizes gold microelectrodes. Both methods have variables that can make them useful in certain situations, however, the focus is on how reliable the xCELLigence program is in comparison to more traditional methods of quantifying viral particles.
APA, Harvard, Vancouver, ISO, and other styles
3

Skeoch, Sarah. "Investigation of atherosclerosis and the effects of anti-inflammatory therapy on plaque morphology in rheumatoid arthritis." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/investigation-of-atherosclerosis-and-the-effects-of-anti-inflammatory-therapy-on-plaque-morphology-in-rheumatoid-arthritis(971c3727-54a8-49ff-aab7-8a6e0aa9d1ba).html.

Full text
Abstract:
Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune condition, characterised by an inflammatory arthritis. It is associated with a 50% increased risk of cardiovascular (CV) mortality. Chronic inflammation is thought to lead to accelerated atherosclerosis in RA. There is some evidence to suggest that patients have a more inflammatory, unstable atherosclerotic plaque phenotype. The impact of advances in RA treatment, on cardiovascular co-morbidity remains unclear. The aims of the current study were to employ non-invasive imaging techniques to test the hypothesis that RA patients have more inflammatory, unstable atherosclerotic plaques compared to unaffected individuals and that treatment of active arthritis would lead to alterations in plaque composition and inflammation. Secondary aims were to evaluate the association of clinical phenotype and potential serological biomarkers of CV risk with plaque presence and phenotype. Methods: A prospective pilot study of patients with active RA and age and sex matched controls was conducted. Subjects underwent clinical and serological evaluation, then carotid artery ultrasound was performed to screen for carotid plaque. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) was performed on those with suitable plaque. A subgroup of patients had a carotid artery positron emission tomography (PET) scan. Patients were followed up with repeat clinical, serological and DCE-MRI assessments. The primary outcome evaluated was difference in plaque inflammation measured on DCE-MRI between patients and controls and in patients longitudinally. Secondary outcomes included differences in plaque composition on DCE-MRI, plaque inflammation on PET and the relationship of clinical, serological and imaging findings. Results: 130 patients and 52 controls were recruited and screened for carotid plaque. There was a higher prevalence of plaque on ultrasound in the patient group (53% vs 36%) and plaque was independently associated with high sensitivity c reactive protein (hsCRP). Carotid DCE- MRI data was analysed in 15 patients and 5 controls. There was no significant difference in plaque inflammation on DCE-MRI between the groups. However there was a significantly higher rate of plaque calcification in patients, despite similar plaque burden in both groups (73.3% vs 20%, p=0.038). All 15 patients exhibited features of high-risk plaque. Plaque inflammation was seen in all 13 patients in whom PET imaging was undertaken. No significant improvement in plaque inflammation was detected on DCE-MRI over time, which was in keeping with the lack of clinical improvement found in most cases. ConclusionsIncreased prevalence of atherosclerosis and differences in plaque phenotype were observed in this study and findings would support the hypothesis that patients have a more high-risk plaque phenotype. The high prevalence of calcified lesions in RA is a novel finding which warrants further investigation. The study was underpowered to detect significant changes in plaque inflammation, measured on DCE-MRI, between the groups and in patients over time. However, this study provides valuable data with which to plan a larger study to investigate the effects of anti-inflammatory therapy on atherosclerosis in RA in the future.
APA, Harvard, Vancouver, ISO, and other styles
4

Metzger, Katja Annett. "Diagnostik und Therapie atherosklerotischer Plaques mittels Ultraschallkontrastmittel am Mausmodell." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-181773.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Stein, Ronja Maria Verfasser], and Michael [Akademischer Betreuer] [Hertl. "Photodynamische Therapie und Pathomechanismen des Lichen planus / Ronja Maria Stein ; Betreuer: Michael Hertl." Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1136718400/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Scavo, Linda. "Effet de la mélatonine sur le risque d’ostéoporose, le métabolisme énergétique cérébrale et la remyélinisation dans un modèle expérimental de souris EAE Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS108.

Full text
Abstract:
La Sclérose en plaques (SEP) est une maladie auto-immune chronique démyélinisante et neurodégénérative du SNC. Elle représente la première cause de handicap non traumatique chez l’adulte jeune et surtout les femmes. Malgré tous les efforts des chercheurs, la cause exacte de la SEP reste inconnue à ce jour. Selon eux, la SEP est considérée une maladie qui survient en présence des facteurs environnementaux combinés à des facteurs génétiques. La thérapie actuelle utilise des médicaments qui suppriment les attaques immunologiques sans supprimer tout le système immunitaire. La mélatonine s’est révélée d’être un candidat neuroprotecteur puissant pour réduire la perte de la myéline.Le but de ce travail est d’examiner la corrélation clinique entre la mélatonine sérique et la proCT chez les patients atteints de SEP et d’évaluer l’effet de la mélatonine sur l’ostéoporose, les voies métaboliques et la remyélinisation au niveau du cerveau in vivo. Pour ce faire, différentes techniques de biologie moléculaire et cellulaire ont été utilisées dans le modèle expérimental d'encéphalomyélite auto-immune (EAE).Les résultats obtenus se divisent en trois parties. Dans la première partie, Les données ont montré une augmentation significative des taux sériques de proCT chez les patients atteints de SEP, inversement corrélée aux niveaux de mélatonine et celui de l’ostéocalcine OCN par rapport aux sujets sains. Dans la seconde partie, nous avons démontré que la mélatonine a diminué les scores cliniques moyens, a réduit significativement les taux sériques de proCT et a augmenté le niveau de 25-hydroxyvitamine D, du calcium et de l’OCN chez les souris EAE par rapport au souris EAE témoins. Dans la troisième partie, les résultats ont montré que la mélatonine a augmenté le niveau des cytokines anti-inflammatoires (l’interleukine-10 (IL-10) et l’interleukine-4 (IL-4)) et a diminué le taux des cytokines pro-inflammatoires (le facteur de nécrose tumorale–alpha (TNF-α) et l’interleukine 1-bêta (IL-1β)) chez les souris EAE par rapport aux souris EAE témoins. Nous avons aussi démontré que le taux de la glycoprotéine oligodendrocytaire de la myéline (MOG), le taux de la protéine basique de la myéline (MBP) et le taux de la protéine basique oligodendrocytaire associée à la myéline (MOBP) ont étéaugmentés par celle-ci. De plus, elle a entraîné une augmentation significative des concentrations cérébrales d’acétate, de N-acétylaspartate (NAA) et de 3-hydroxy-3-méthylglutaryl-Coenzyme-A réductase (HMGCR). Les niveaux d’expression de l’ARNm et des protéines de pyruvate déshydrogénase kinase-4 (PDK-4) ont également augmenté chez les souris traitées à la mélatonine par rapport aux souris EAE non traitées. Le traitement à la mélatonine a entraîné une augmentation des taux de lactate dans le cerveau, alors que l'activité du complexe de pyruvate déshydrogénase (PDC) actif et total, enzyme sous le contrôle de PDK-4, a été supprimée.En conclusion, cette étude suggère que ProCT pourrait être un biomarqueur chez les patients atteints de SEP. Les résultats obtenus sur les souris EAE traitées à la mélatonine démontrent son importance sur l’atténuation de la gravité de la maladie et de l’inflammation intracérébrale ainsi que sur l’amélioration du métabolisme osseux qui a pour conséquent une réduction de l’ostéoporose. De même, ce traitement porte une importance sur la réduction des médiateurs inflammatoires tout en stimulant l’oligodendrogénèse. Ainsi, la mélatonine exerce un effet modulatoire sur les voies métaboliques impliquées dans le métabolisme cérébral et améliore le dysfonctionnement mitochondrial<br>Multiple Sclerosis (MS) is a chronic auto-immune demyelinating and neurodegenerative disease of the CNS. It represents the leading cause of non-traumatic disability in young adults and especially women. Despite all the efforts of researchers, the exact cause of MS remains unknown to this day. According to them, MS is considered a disease that occurs in the presence of environmental factors combined with genetic factors. Current therapy uses drugs that suppress immunological attacks without suppressing the entire immune system. Melatonin has been shown to be a potent neuroprotective candidate to reduce the loss of myelin.The aim of this work is to examine the clinical correlation between serum melatonin and proCT in MS patients and to assess the effect of melatonin on osteoporosis, metabolic pathways and remyelination in the brain. in vivo. To do this, different molecular and cellular biology techniques were used in the experimental model of autoimmune encephalomyelitis (EAE).The results obtained are divided into three parts. In the first part, the data showed a significant increase in serum proCT levels in MS patients, inversely correlated with melatonin and osteocalcin OCN levels compared to healthy subjects. In the second part, we demonstrated that melatonin decreased the average clinical scores, significantly reduced serum proCT levels and increased the level of 25-hydroxyvitamin D, calcium and OCN in EAE mice compared to control EAE mice. In the third part, the results showed that melatonin increased the level of anti-inflammatory cytokines (interleukin-10 (IL-10) and interleukin-4 (IL-4)) and decreased the rate of pro-inflammatory cytokines (tumor necrosis factor – alpha (TNF-α) and interleukin 1-beta (IL-1β)) in EAE mice compared to control EAE mice. We also demonstrated that the level of myelin oligodendrocyte glycoprotein (MOG), the level of myelin basic protein (MBP) and the level of myelin oligodendrocytic basic protein (MOBP) wereincreased by it. In addition, it has led to a significant increase in brain concentrations of acetate, N-acetylaspartate (NAA) and 3-hydroxy-3-methylglutaryl-Coenzyme-A reductase (HMGCR). Expression levels of mRNA and pyruvate dehydrogenase kinase-4 (PDK-4) proteins also increased in melatonin-treated mice compared to untreated EAE mice. Treatment with melatonin resulted in increased lactate levels in the brain, while the activity of the active and total pyruvate dehydrogenase (PDC) complex, an enzyme under the control of PDK-4, was suppressed.In conclusion, this study suggests that ProCT may be a biomarker in patients with MS. The results obtained on melatonin-treated EAE mice demonstrate its importance in reducing the severity of the disease and intracerebral inflammation, as well as improving bone metabolism, which consequently reduces osteoporosis. Likewise, this treatment is important for the reduction of inflammatory mediators while stimulating oligodendrogenesis. Thus, melatonin exerts a modulatory effect on the metabolic pathways involved in brain metabolism and improves mitochondrial dysfunction
APA, Harvard, Vancouver, ISO, and other styles
7

Metzger, Katja Annett [Verfasser], and Sven [Akademischer Betreuer] Reese. "Diagnostik und Therapie atherosklerotischer Plaques mittels Ultraschallkontrastmittel am Mausmodell / Katja Annett Metzger. Betreuer: Sven Reese." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1070762946/34.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Carty, Nikisha Christine. "Recombinant AAV Gene Therapy and Delivery." Scholar Commons, 2009. https://scholarcommons.usf.edu/etd/1890.

Full text
Abstract:
Alzheimer's disease (AD), first characterized in the early 20th century, is a common form of dementia which can occur as a result of genetic mutations in the genes encoding presenilin 1, presenilin 2, or amyloid precursor protein (APP). These genetic alterations can accelerate the pathological characteristics of AD, including the formation of extracellular neuritic plaques composed of amyloid beta peptides and the formation of intracellular neurofibrillary tangles consisting of hyperphosphorylated tau protein. Ultimately, AD results in gross neuron loss in the brain which is evidenced clinically as a progressive decline in mental capacity. A strong body of scientific evidence has previously demonstrated that the driving factor in the pathogenesis of AD is potentially the accumulation of Aß peptides in the brain. Thus, reduction of Aß deposition is a major therapeutic strategy in the treatment of AD. Recently it has been suggested that Aß accumulation in the brain is modulated, not only by Aß production, but also by its degradation. Several important studies have demonstrated that Aß degradation is modulated by several endogenous zinc metalloproteases shown to have amyloid degrading capabilities. These endogenous proteases include neprilysin (NEP), endothelin converting enzyme (ECE), insulin degrading enzyme (IDE) and matrix metalloprotease 9 (MMP9). In this investigation we study the effects of upregulating expression of several of these proteases through administration of recombinant adeno-associated viral vector (rAAV) containing both endogenous and synthetic genes for ECE and NEP on amyloid deposition in amyloid precursor protein (APP) plus presenilin-1 (PS1) transgenic mice. rAAV administration directly into the brain resulted in increased expression of ECE and NEP and a substantial decrease in amyloid pathology. We were able to significantly increase the area of viral distribution by using novel delivery methods resulting in increased gene expression and distribution. These data support great potential of gene therapy as a method of treatment for neurological diseases. Optimization of gene transfer methods aimed at a particular cell type and brain region in the CNS can be accomplished using AAV serotype specificity and novel delivery techniques leading to successful gene transduction thus providing a promising therapeutic avenue through which to treat AD.
APA, Harvard, Vancouver, ISO, and other styles
9

Sarlon-Bartoli, Gabrielle. "Outils diagnostique et thérapeutique innovants de la dysfonction vasculaire au cours des maladies artérielles périphériques." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5510/document.

Full text
Abstract:
Les maladies artérielles périphériques athéromateuses sont graves : l'atteinte des troncs supra-aortiques est à risque d'accident vasculaire cérébral et l'atteinte des artères des membres inférieurs est à risque d'amputation et de décès cardiovasculaire. Le développement de stratégies innovantes capables d'optimiser le diagnostic précoce et le traitement de ces maladies est un enjeu considérable.Nous montrons une corrélation entre deux biomarqueurs inflammatoires, les microparticules leucocytaires (MPL) et la lipoprotéine phospholipase A2, et l'instabilité de la plaque carotidienne définie histologiquement, dans une population de patients porteurs d'une sténose carotidienne serrée. Les MPL sont élevées de façon significative et indépendante y compris chez les patients asymptomatiques porteurs d'une sténose carotidienne serrée instable. Ainsi, le taux circulant de MPL aider à sélectionner les meilleurs candidats à une chirurgie carotidienne préventive parmi les patients ayant une sténose carotidienne serrée asymptomatique. Deuxièmement, nous montrons que l'administration ex vivo d'érythropoïétine (EPO) améliore les capacités proangiogéniques des progéniteurs endothéliaux circulants tardifs in vitro et in vivo sur un modèle d'ischémie de patte de souris nude. Ces effets semblent médiés par la sous-unité CD131 du récepteur à l'EPO. Si ces résultats se confirment chez l'homme, l'EPO pourrait être utilisée pour améliorer les capacités de revascularisation des progéniteurs endothéliaux circulants tardifs circulants humains avant réinjection autologue comme produit de thérapie cellulaire chez des patients atteints d'ischémie critique des membres inférieurs<br>Atherosclerotic peripheral arterial diseases are frequent and severe. They undertake the functional and vital prognosis of patients: lesions of supra-aortic trunks are at risk of stroke and lesions of lower limb arteries are at risk of amputation and cardiovascular death. The development of innovative strategies that optimize early diagnosis and therapeutic management of these diseases is thus a considerable challenge.In this work, we show a correlation between inflammatory biomarkers, leukocyte microparticles and lipoprotein phospholipase A2, and carotid plaque instability defined histologically, in a population of patients with tight carotid stenosis with or without neurological symptoms. Leukocyte microparticles are elevated significantly and independently including asymptomatic patients with tight unstable carotid stenosis. Thus, the circulating levels of leukocyte microparticles could be a tool in the future to select the best candidates for carotid surgery among patients with asymptomatic carotid stenosis tight.Second, we show that ex vivo administration of erythropoietin improves the proangiogenic capacity of late circulating endothelial progenitor in vitro and in vivo in a mouse model of hindlimb ischemia. These effects appear mediated by CD131 subunit of the receptor for erythropoietin. If these results are confirmed in humans, erythropoietin could be used to improve the revascularization capacity of late circulating endothelial progenitor before reinjection as autologous cell therapy product in patients with critical ischemia of the lower limbs
APA, Harvard, Vancouver, ISO, and other styles
10

Gamper, Coralie. "Nanoparticules dérivées de virus de plante pour le traitement et l'imagerie du cancer." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ038/document.

Full text
Abstract:
Les possibilités de combinaison thérapeutiques offertes par les nanoparticules ont ouvert un nouveau champ d’investigation pour la recherche sur le cancer. Dans ce projet de recherche, des nanoparticules dérivées de la protéine de capside du virus de la mosaïque du tabac (TMV) ont été utilisées afin de transporter différents peptides thérapeutiques ciblant le récepteur neuropiline-1. Cette stratégie a permis de solubiliser un peptide fortement hydrophobe ayant préalablement démontré son efficacité anticancéreuse sur des lignées de cancer du sein humain et de glioblastome. Les résultats obtenus ont également permis de démontrer la possibilité de combiner différents peptides thérapeutiques via l’auto-assemblage de la protéine de capside du TMV<br>Nanoparticles play an ever increase role in carrying therapeutic compounds in the cancer field. In this research project, the coat protein of Tobacco mosaic virus (TMV) was used as nanocarrier to solubilize a hydrophobic peptide interfering with the transmembrane domain of neuropilin-1. The nanoparticles created have conserved the antiangiogenic and antimigratory effect of the therapeutic peptide. This strategy was also used to create nanoparticles carrying a peptide targeting the ectodomain of neuropilin-1. The two types of nanoparticles were then assembled through auto-assembling ability of the coat protein. These nanoparticles also exhibit antiangiogenic ability thus, confirming the validity of this approach to combine therapeutic peptides
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Plague, therapy"

1

Protocol for a plague: AIDS research, access to life-saving therapies & drug approval. Monument Press, 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Ron, Waksman, and Serruys P. W, eds. Handbook of the vulnerable plaque. Martin Dunitz, 2004.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
3

Valentin, Fuster, and Insull William, eds. Assessing and modifying the vulnerable atherosclerotic plaque. Futura Pub. Co., 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
4

L, Kalkwarf Kenneth, Brunsvold Michael A, and Brooks Carol, eds. Plaque and calculus removal: Considerations for the professional. Quintessence Pub. Co., 1994.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
5

Renu, Virmani, ed. The vulnerable atherosclerotic plaque: Strategies for diagnosis and management. Blackwell Futura, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
6

Valentin, Fuster, ed. The vulnerable atherosclerotic plaque: Understanding, identification, and modification. Futura Pub. Co., 1999.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
7

Harrison, Sarah (Sarah J. C.). and College of Occupational Therapists, eds. Fatigue management for people with multiple sclerosis. 2nd ed. College of Occupational Therapists, 2007.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
8

La santé par les vitamines et les minéraux. Sélection Reader's Digest, 2003.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
9

MS - living symptom free: The true story of an MS patient. [publisher not identified], 2011.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
10

Dumesnil, Jean G. Bon poids, bon coeur avec la methode Montignac. Flammarion Quebec, 2002.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Book chapters on the topic "Plague, therapy"

1

Filippov, Andrey A., Kirill V. Sergueev, Yunxiu He, et al. "Bacteriophage Therapy of Experimental Bubonic Plague in Mice." In Advances in Yersinia Research. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-3561-7_41.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Dragun, Anthony E., Paul J. Schilling, Tod W. Speer, et al. "Episcleral Plaque Therapy." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_1105.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Dragun, Anthony E., Paul J. Schilling, Tod W. Speer, et al. "Eye Plaque Therapy." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_1119.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Yue, Ning J., Kent Lambert, Jay E. Reiff, et al. "Radioactive Plaque Therapy." In Encyclopedia of Radiation Oncology. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-540-85516-3_1236.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Shiohara, Tetsuo, Yoshiko Mizukawa, and Yoko Kano. "Lichen Planus." In Therapy of Skin Diseases. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-78814-0_22.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Dumitrescu, Alexandrina L., and Masaru Ohara. "Antimicrobial Resistance of Dental Plaque Biofilm." In Antibiotics and Antiseptics in Periodontal Therapy. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13211-7_1.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Feldman, Laurent J., and Jeffrey M. Isner. "Gene therapy for the vulnerable atherosclerotic plaque." In Developments in Cardiovascular Medicine. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-1577-0_24.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Makris, Gregory C., Andrew Nicolaides, Anthi Lavida, and George Geroulakos. "Effect of Statin Therapy on Carotid Plaque Morphology." In Ultrasound and Carotid Bifurcation Atherosclerosis. Springer London, 2011. http://dx.doi.org/10.1007/978-1-84882-688-5_35.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Tabor, Peter, and Winfried E. Alberti. "Ocular Iodine Plaque Therapy: Dosimetry and Treatment Planning." In Radiotherapy of Intraocular and Orbital Tumors. Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-97011-5_37.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Fulton, W. F. M. "Koronaratherosklerose, Fissurbildung der Plaque und Thrombose." In Thrombolytische Therapie des akuten Herzinfarkts. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-72754-2_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Plague, therapy"

1

Lykova, Marina P. "The content of speech therapy work on the development of language analysis and synthesis skills in preschool children." In Особый ребенок: Обучение, воспитание, развитие. Yaroslavl state pedagogical university named after К. D. Ushinsky, 2021. http://dx.doi.org/10.20323/978-5-00089-474-3-2021-326-330.

Full text
Abstract:
The article presents the content of speech therapy work on the development of language analysis and synthesis skills in preschool children. The author offers a system of games and exercises for recognizing sounds, determining the number, sequence and place of a word in a sentence, forming the action of sound, syllabic analysis and synthesis in the mental plane
APA, Harvard, Vancouver, ISO, and other styles
2

Lantz, Jonas, Roland Gårdhagen, Joakim Wren, and Matts Karlsson. "Heating in a Stenosed Coronary Artery With Pulsating Flow and Non-Newtonian Viscosity." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192532.

Full text
Abstract:
Cardiovascular disease is the most prevalent cause of death in the developed countries and most deaths are due to coronary atherosclerosis [1]. During the development of atherosclerosis, several stages can be distinguished including vulnerable plaque. This group of plaque has an inclination for erosion and rupture and is therefore of particular interest. Due to the inflammatory response of vulnerable plaque including an increased metabolism and thereby a locally increased temperature, it is possible to detect such warm cores by intracoronally temperature measurement under some prerequisitions. Temperature differences up to 2.2 K on the surface of carotid plaques have been measured [2], but the relation between plaque vulnerability, inflammatory response, temperature increase and possibility to detection by means of temperature measurement is far from fully perceived.
APA, Harvard, Vancouver, ISO, and other styles
3

Sumali, Hartono, Jordan E. Massad, Pavel M. Chaplya, and Jeffrey W. Martin. "Deflection Control of a Corner-Supported Plate Using Segmented In-Plane Actuators." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61141.

Full text
Abstract:
This paper describes an array of in-plane piezoelectric actuator segments laminated onto a corner-supported substrate to create a thin bimorph for reflector applications. An electric field distribution over the actuator segments causes the segments to expand or contract, thereby effecting plate deflection. To achieve a desired bimorph shape, the shape is first expressed as a two-dimensional series expansion. Then, using coefficients from the series expansion, an inverse problem is solved that determines the electric field distribution realizing the desired plate shape. A static example is presented where the desired deflection shape is a paraboloid.
APA, Harvard, Vancouver, ISO, and other styles
4

Perttilä, Robert, John Roque, Lasse Orsila, et al. "Towards high-throughput light-activated drug discovery using automated plate illuminator." In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXX, edited by David H. Kessel and Tayyaba Hasan. SPIE, 2021. http://dx.doi.org/10.1117/12.2578408.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Rios-Sanchez, E., S. Fenix-Caballero, J. Diaz-Navarro, et al. "CP-183 Effectiveness and safety of biological therapy optimisation in chronic plaque psoriasis." In 22nd EAHP Congress 22–24 March 2017 Cannes, France. British Medical Journal Publishing Group, 2017. http://dx.doi.org/10.1136/ejhpharm-2017-000640.181.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Ohmori, Sayaka, Takeshi Yanagihara, and Tsunenori Arai. "Direct photodynamic therapy for vulnerable plaque: investigation of light dosimetry for depth control." In Biomedical Optics 2004, edited by Steven L. Jacques and William P. Roach. SPIE, 2004. http://dx.doi.org/10.1117/12.528993.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Utami, Nindya P. B. S., and Siti Farida. "Centella asiatica as a potential plaque stabilizer: Future preventive therapy for cardiovascular disease." In THE 4TH BIOMEDICAL ENGINEERING’S RECENT PROGRESS IN BIOMATERIALS, DRUGS DEVELOPMENT, HEALTH, AND MEDICAL DEVICES: Proceedings of the International Symposium of Biomedical Engineering (ISBE) 2019. AIP Publishing, 2019. http://dx.doi.org/10.1063/1.5139370.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Vesala, Laura, Robert Perttilä, Elias Kokko, Lasse Orsila, and Petteri Uusimaa. "Light-activated drug release using an automated well plate illuminator." In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, edited by David H. Kessel and Tayyaba Hasan. SPIE, 2022. http://dx.doi.org/10.1117/12.2608745.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Wentzel, Jolanda J., Harald C. Groen, Rose van der Giessen, et al. "Vascular Remodeling During Atherosclerotic Plaque Build Up Is Controlled by the Plaque Free Part of the Vessel Wall." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192624.

Full text
Abstract:
Glagov et al. observed that positive, compensatory vascular remodeling during plaque build up prevents lumen narrowing until plaque burden, this is the relative plaque area to media bounded area, exceeds a threshold of 40% [1]. Until now it is not clear what mechanism controls the compensatory vascular remodeling during the atherosclerotic plaque build up and what determines absence or limits compensatory vascular remodeling. Plaque burden does not seem to reflect a parameter, which could serve as a limiting step in the known control process in the vascular system. For instance, healthy arteries control vascular remodeling by fluid flow induced shear stress via a number of endothelium dependent pathways [2]. The endothelium at the atherosclerotic plaque side is considered to be dysfunctional [2] and might thereby limit the remodeling process. Since plaques are mostly eccentric, we hypothesize that the healthy part of the artery (or plaque free wall) will respond to changes in shear stress and will determine the capacity of the arteries to remodel up till the moment of complete circumferential involvement of the disease. We investigated whether the size of the plaque free wall contributes to vascular remodeling over a 3 year period using serial intravascular ultrasound measurements by determining 1) the frequency of positive remodeling in segments with varying size of plaque free vessel wall 2) the degree of vascular remodeling for segments with varying size of plaque free vessel wall.
APA, Harvard, Vancouver, ISO, and other styles
10

Liang, Yun, Hui Zhu, Thomas Gehrig, and Morton H. Friedman. "Coronary Artery Wall Strain Estimation From Clinical IVUS Images." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176256.

Full text
Abstract:
Atherosclerotic plaque rupture is responsible for the majority of acute coronary syndromes and myocardial infarctions. Intravascular ultrasound (IVUS) imaging is a widely available clinical technique providing real time cross-sectional images of the vessel wall and plaque morphometry. However, IVUS echo images have limited ability to predict the vulnerability of the plaque. The mechanical behavior of the plaque is consistent with its underlying components, suggesting that measurements of plaque mechanical response can be used to assess the likelihood of plaque rupture [1]. Arterial wall strain in response to luminal pressure change is such a measurable quantity. IVUS elastography has been developed to measure the radial strain through correlation analysis of the IVUS radiofrequency (RF) signal [2]. Due to the movements of IVUS catheter caused by cardiac motion and the nonlinearity of tissue deformation, reliable strain is obtained by elastography only when the tissue motion is aligned with the RF direction and the RF traces correspond to the same axial location. This is difficult to achieve in vivo. We have developed a strain estimation method based on IVUS image registration. This 2D processing method has the ability to overcome in-plane catheter movement and heterogeneous tissue deformation, thereby increasing its accuracy. Using retrospectively retrieved cardiac phase information, we propose a practical method to estimate cross-sectional coronary arterial wall strain distribution from clinically acquired images during a conventional IVUS procedure.
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Plague, therapy"

1

Xue, Kaiyuan, Haiyuan Wu, Lidan Jia, and Suqing Yang. Pricking-bloodletting cupping therapy for plaque psoriasis：A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.9.0126.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Zou, Jiahua, Gang Huang, ChuXiang Hu, et al. Fire needle therapy for blood stasis syndrome of plaque psoriasis : A protocol for systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.2.0007.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Alarcón, Marco, Tatiana Amagua, Donald Morales, and Ana Lucia Seminario. EFFECT OF PERIODONTAL TREATMENT IN HIV+ PATIENS: A SYSTEMATIC REVIEW. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.1.0032.

Full text
Abstract:
Review question / Objective: The objective of our study is to evaluate whether periodontal treatment influences clinical outcomes and immunological conditions in HIV+ patients. (P) Participants: VIH+ patients. (I) Interventions: Surgical treatment, photodynamic therapy, antimicrobials, others. (C) Comparison: Non-surgical treatment. (O) Outcome measures: - Periodontal outcomes: plaque scores, bleeding on probing, periodontal pocket Depth, clinical attachment levels; - VIH outcomes: -Count CD4+; -Microbiological analysis. Condition being studied: Our study will analyze the effect of periodontal treatment in HIV+ patients and will evaluate changes in periodontal, immunological and microbiological parameters.
APA, Harvard, Vancouver, ISO, and other styles
4

Wen, Bei, Li Xu, and Yuguang Huang. Which minimally invasive therapy is most effective for the treatment of postherpetic neuralgia? An update meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.10.0114.

Full text
Abstract:
Review question / Objective: Which minimally invasive therapy is the best choice to alleviate pain for patients suffering from postherpetic neuralgia? Eligibility criteria: The eligibility criteria are interpreted under the PICOS (P, participants; I, interventions; C, comparison; O, outcomes; S, study design) framework. (1) P: ParticipantsInclusion criteria: Patients suffering from postherpetic neuralgia (the pain lasting more than 3 months after the onset of herpes zoster rash eruption or more than 1 month after the vesicles have healed).Exclusion criteria: 1. Patients who had other neuropathic pain; 2. Patients with acute or subacute zoster-related pain.(2) I: Interventions Inclusion criteria: Interventional treatments applied to PHN patients, as follows: 1) nerve block (including epidural block, intrathecal block, dorsal root ganglion block, intercostal nerve block, paravertebral block, erector spinae plane block);2) subcutaneous injection (including subcutaneous injection of normal saline, local anesthetics, corticosteroids, MeB12 as well as local infiltration);3) stellate ganglion block;4) subcutaneous botulinum toxin type A injection;5) pulsed radiofrequency with or without.
APA, Harvard, Vancouver, ISO, and other styles
5

Saldanha, Ian J., Wangnan Cao, Justin M. Broyles, et al. Breast Reconstruction After Mastectomy: A Systematic Review and Meta-Analysis. Agency for Healthcare Research and Quality (AHRQ), 2021. http://dx.doi.org/10.23970/ahrqepccer245.

Full text
Abstract:
Objectives. This systematic review evaluates breast reconstruction options for women after mastectomy for breast cancer (or breast cancer prophylaxis). We addressed six Key Questions (KQs): (1) implant-based reconstruction (IBR) versus autologous reconstruction (AR), (2) timing of IBR and AR in relation to chemotherapy and radiation therapy, (3) comparisons of implant materials, (4) comparisons of anatomic planes for IBR, (5) use versus nonuse of human acellular dermal matrices (ADMs) during IBR, and (6) comparisons of AR flap types. Data sources and review methods. We searched Medline®, Embase®, Cochrane CENTRAL, CINAHL®, and ClinicalTrials.gov from inception to March 23, 2021, to identify comparative and single group studies. We extracted study data into the Systematic Review Data Repository Plus (SRDR+). We assessed the risk of bias and evaluated the strength of evidence (SoE) using standard methods. The protocol was registered in PROSPERO (registration number CRD42020193183). Results. We found 8 randomized controlled trials, 83 nonrandomized comparative studies, and 69 single group studies. Risk of bias was moderate to high for most studies. KQ1: Compared with IBR, AR is probably associated with clinically better patient satisfaction with breasts and sexual well-being but comparable general quality of life and psychosocial well-being (moderate SoE, all outcomes). AR probably poses a greater risk of deep vein thrombosis or pulmonary embolism (moderate SoE), but IBR probably poses a greater risk of reconstructive failure in the long term (1.5 to 4 years) (moderate SoE) and may pose a greater risk of breast seroma (low SoE). KQ 2: Conducting IBR either before or after radiation therapy may result in comparable physical well-being, psychosocial well-being, sexual well-being, and patient satisfaction with breasts (all low SoE), and probably results in comparable risks of implant failure/loss or need for explant surgery (moderate SoE). We found no evidence addressing timing of IBR or AR in relation to chemotherapy or timing of AR in relation to radiation therapy. KQ 3: Silicone and saline implants may result in clinically comparable patient satisfaction with breasts (low SoE). There is insufficient evidence regarding double lumen implants. KQ 4: Whether the implant is placed in the prepectoral or total submuscular plane may not be associated with risk of infections that are not explicitly implant related (low SoE). There is insufficient evidence addressing the comparisons between prepectoral and partial submuscular and between partial and total submuscular planes. KQ 5: The evidence is inconsistent regarding whether human ADM use during IBR impacts physical well-being, psychosocial well-being, or satisfaction with breasts. However, ADM use probably increases the risk of implant failure/loss or need for explant surgery (moderate SoE) and may increase the risk of infections not explicitly implant related (low SoE). Whether or not ADM is used probably is associated with comparable risks of seroma and unplanned repeat surgeries for revision (moderate SoE for both), and possibly necrosis (low SoE). KQ 6: AR with either transverse rectus abdominis (TRAM) or deep inferior epigastric perforator (DIEP) flaps may result in comparable patient satisfaction with breasts (low SoE), but TRAM flaps probably increase the risk of harms to the area of flap harvest (moderate SoE). AR with either DIEP or latissimus dorsi flaps may result in comparable patient satisfaction with breasts (low SoE), but there is insufficient evidence regarding thromboembolic events and no evidence regarding other surgical complications. Conclusion. Evidence regarding surgical breast reconstruction options is largely insufficient or of only low or moderate SoE. New high-quality research is needed, especially for timing of IBR and AR in relation to chemotherapy and radiation therapy, for comparisons of implant materials, and for comparisons of anatomic planes of implant placement.
APA, Harvard, Vancouver, ISO, and other styles
6

guo, wenxuan, WH Chen, F. Wu, et al. Can locked fibula nail replace plate fixation for treatment of acute ankle fracture? A protocol for systematic review and meta-analysis of randomized controlled trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.7.0094.

Full text
Abstract:
Review question / Objective: We seek to conduct a meta-analysis of relevant studies to evaluate and compare functional outcomes and complication rates between locked fibula intramedullary nail fixation and plate fixation for treatment of ankle fractures. Condition being studied: Ankle fractures, with an incidence rate of 4.22/10, 000 person-years in the United States, are one of the most common lower extremity fractures. Currently, the standard surgical treatment approaches for unstable ankle fractures involves open reduction and internal fixation (ORIF) with plates and screws. However, ORIF has resulted in little efficacy during treatment of fractures since the 1960s, while plate and screw fixation has also been associated with several complications. Previous studies have shown that closed reduction and internal fixation (CRIF) with fibula intramedullary nail (IMN) has achieved satisfactory efficacy in treatment of ankle fractures, and is associated with low complication rates. Additionally, a systematic review showed that a locked intramedullary nail (LIMN) device provides better stability and rotation control, thereby reducing the risk of nail migration and loss of fixation, compared to unlocked nails. Therefore, a meta-analysis is imperative to provide evidence on whether LIMN can replace PF for treatment of ankle fractures, owing to an increase in related studies that have been published in recent years.
APA, Harvard, Vancouver, ISO, and other styles
7

Tidd, Alexander N., Richard A. Ayers, Grant P. Course, and Guy R. Pasco. Scottish Inshore Fisheries Integrated Data System (SIFIDS): work package 6 final report development of a pilot relational data resource for the collation and interpretation of inshore fisheries data. Edited by Mark James and Hannah Ladd-Jones. Marine Alliance for Science and Technology for Scotland (MASTS), 2019. http://dx.doi.org/10.15664/10023.23452.

Full text
Abstract:
[Extract from Executive Summary] The competition for space from competing sectors in the coastal waters of Scotland has never been greater and thus there is a growing a need for interactive seascape planning tools that encompass all marine activities. Similarly, the need to gather data to inform decision makers, especially in the fishing industry, has become essential to provide advice on the economic impact on fishing fleets both in terms of alternative conservation measures (e.g. effort limitations, temporal and spatial closures) as well as the overlap with other activities, thereby allowing stakeholders to derive a preferred option. The SIFIDS project was conceived to allow the different relevant data sources to be identified and to allow these data to be collated in one place, rather than as isolated data sets with multiple data owners. The online interactive tool developed as part of the project (Work Package 6) brought together relevant data sets and developed data storage facilities and a user interface to allow various types of user to view and interrogate the data. Some of these data sets were obtained as static layers which could sit as background data e.g. substrate type, UK fishing limits; whilst other data came directly from electronic monitoring systems developed as part of the SIFIDS project. The main non-static data source was Work Package 2, which was collecting data from a sample of volunteer inshore fishing vessels (&lt;12m). This included data on location; time; vessel speed; count, time and position of deployment of strings of creels (or as fleets and pots as they are also known respectively); and a count of how many creels were hauled on these strings. The interactive online tool allowed all the above data to be collated in a specially designed database and displayed in near real time on the web-based application.
APA, Harvard, Vancouver, ISO, and other styles
8

Anderson, Gerald L., and Kalman Peleg. Precision Cropping by Remotely Sensed Prorotype Plots and Calibration in the Complex Domain. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7585193.bard.

Full text
Abstract:
This research report describes a methodology whereby multi-spectral and hyperspectral imagery from remote sensing, is used for deriving predicted field maps of selected plant growth attributes which are required for precision cropping. A major task in precision cropping is to establish areas of the field that differ from the rest of the field and share a common characteristic. Yield distribution f maps can be prepared by yield monitors, which are available for some harvester types. Other field attributes of interest in precision cropping, e.g. soil properties, leaf Nitrate, biomass etc. are obtained by manual sampling of the filed in a grid pattern. Maps of various field attributes are then prepared from these samples by the "Inverse Distance" interpolation method or by Kriging. An improved interpolation method was developed which is based on minimizing the overall curvature of the resulting map. Such maps are the ground truth reference, used for training the algorithm that generates the predicted field maps from remote sensing imagery. Both the reference and the predicted maps are stratified into "Prototype Plots", e.g. 15xl5 blocks of 2m pixels whereby the block size is 30x30m. This averaging reduces the datasets to manageable size and significantly improves the typically poor repeatability of remote sensing imaging systems. In the first two years of the project we used the Normalized Difference Vegetation Index (NDVI), for generating predicted yield maps of sugar beets and com. The NDVI was computed from image cubes of three spectral bands, generated by an optically filtered three camera video imaging system. A two dimensional FFT based regression model Y=f(X), was used wherein Y was the reference map and X=NDVI was the predictor. The FFT regression method applies the "Wavelet Based", "Pixel Block" and "Image Rotation" transforms to the reference and remote images, prior to the Fast - Fourier Transform (FFT) Regression method with the "Phase Lock" option. A complex domain based map Yfft is derived by least squares minimization between the amplitude matrices of X and Y, via the 2D FFT. For one time predictions, the phase matrix of Y is combined with the amplitude matrix ofYfft, whereby an improved predicted map Yplock is formed. Usually, the residuals of Y plock versus Y are about half of the values of Yfft versus Y. For long term predictions, the phase matrix of a "field mask" is combined with the amplitude matrices of the reference image Y and the predicted image Yfft. The field mask is a binary image of a pre-selected region of interest in X and Y. The resultant maps Ypref and Ypred aremodified versions of Y and Yfft respectively. The residuals of Ypred versus Ypref are even lower than the residuals of Yplock versus Y. The maps, Ypref and Ypred represent a close consensus of two independent imaging methods which "view" the same target. In the last two years of the project our remote sensing capability was expanded by addition of a CASI II airborne hyperspectral imaging system and an ASD hyperspectral radiometer. Unfortunately, the cross-noice and poor repeatability problem we had in multi-spectral imaging was exasperated in hyperspectral imaging. We have been able to overcome this problem by over-flying each field twice in rapid succession and developing the Repeatability Index (RI). The RI quantifies the repeatability of each spectral band in the hyperspectral image cube. Thereby, it is possible to select the bands of higher repeatability for inclusion in the prediction model while bands of low repeatability are excluded. Further segregation of high and low repeatability bands takes place in the prediction model algorithm, which is based on a combination of a "Genetic Algorithm" and Partial Least Squares", (PLS-GA). In summary, modus operandi was developed, for deriving important plant growth attribute maps (yield, leaf nitrate, biomass and sugar percent in beets), from remote sensing imagery, with sufficient accuracy for precision cropping applications. This achievement is remarkable, given the inherently high cross-noice between the reference and remote imagery as well as the highly non-repeatable nature of remote sensing systems. The above methodologies may be readily adopted by commercial companies, which specialize in proving remotely sensed data to farmers.
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Plague, therapy' for particular source types:
Journal articles Dissertations / Theses Books
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography