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Dissertations / Theses on the topic 'Plague vaccines'

Author: Grafiati

Published: 4 June 2021

Last updated: 28 July 2025

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1

Mouchet, Le Moal Julie. "Vaccination et risque de démyélinisation : existe-t-il un lien ? Exemples des vaccins anti-hépatite B et anti-papillomavirus." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0015/document.

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Bien que les vaccins représentent une avancée majeure pour la santé publique, le risque d’effets secondaires constitue une menace réelle pour leur acceptation par le grand public et les professionnels de santé. La France se classe, d’ailleurs, comme le pays manifestant la plus grande défiance envers le vaccin. Cela s’est souvent traduit pas des couvertures vaccinales faibles. L’origine de cette perte de confiance est, entre autres, liée à la polémique intense autour du vaccin anti-hépatite B (HB) et le risque de sclérose en plaques dans les années 1990. Le but de cette thèse est d’évaluer le l

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2

Griffin, Kate Frances. "An investigation of the V antigen of Yersinia pestis as a potential vaccine antigen." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324934.

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3

Gregory, Anthony Edward. "Investigating the use of gold nanoparticles in vaccine delivery." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/14528.

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Vaccination is one of the most effective public health interventions in the world, saving millions of lives and preventing the onset of debilitating diseases. With widespread emergence of multi-drug resistant pathogens, the importance of preventative medicine has become even more apparent. However, one of the limiting factors in developing novel vaccines that are both safe and highly immunogenic is the availability of adjuvant delivery systems licensed for human use. The purpose of this study was to investigate the role gold nanoparticles could play as an effective vaccine delivery system. A v

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4

TAYE, KISSI JIMMA. "VACCINE DEVELOPMENT AGAINST PLAGUE, GLANDERS AND MELIOIDOSIS IN THE FORMER SOVIET UNION IN COMPARSION TO THE CURRENT STATE OF GLOBAL KNOWLEDGE." Doctoral thesis, Universitätsbibliothek Leipzig, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-38336.

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The causative agents of plague (Y. pestis), glanders (B. mallei) and melioidosis (B. pseudomallei) are included in critical agents of bioterrorisim. They belong to the most intensively studied agents during cold war, specially in the former Soviet Union (FSU). Mostly what is known about these agents, particularly (Y. pestis ) is not available in English language publications. Many of the studies are written in Russian language and published in Russian scientific journals. Thus, the work is designed to evaluate, published and unpublished Russian language written data obtained, in comparisions t

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5

Duncan, Stephen A. "Analysis of three vaccinia virus genes, one of which is essential for plaque formation." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.305991.

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6

Lülf, Anna-Theresa [Verfasser], and Gerd [Akademischer Betreuer] Sutter. "Fluorescent reporter viruses identify non-plaque-forming virions of vaccinia virus to activate viral gene expression / Anna-Theresa Lülf ; Betreuer: Gerd Sutter." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1127527975/34.

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7

Boqvist, Natalie. "Är ett framtida vaccin mot Alzheimers sjukdom möjligt?" Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-226441.

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Alzheimers sjukdom är en smygande neurodegenerativ demenssjukdom som främst drabbar äldre och som karakteriseras av uppkomsten av amyloidplack och neurofibriller i hjärnan. De vanligaste symptomen är demens, kognitiva problem, inbillningar och aggressivitet. Alzheimer förekommer i två olika former, presenil och senil alzheimer. Den fullständiga mekanismen bakom alzheimer är ännu okänd men två proteiner, beta-amyloid och tau, anses ligga bakom orsaken till alzheimer. Ett tredje inblandat protein som man funnit via genetisk analys är apolipoprotein E. Idag är alzheimer ett växande problem, detta

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8

Becker, Michelle Caitlin. "The Combination of Carboxylesterase-Expressing Oncolytic Vaccinia Virus and Irinotecan." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23653.

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This project combines oncolytic Vaccinia virus (VV) with irinotecan (CPT-11) for the treatment of cancer. VV can infect, replicate in and destroy cancer cells, yet leave healthy cells relatively unaffected. CPT-11 is a chemotherapeutic of which ~5% is converted to the more active chemotherapeutic SN-38 by endogenous carboxylesterase (CE) enzymes. SN-38 is a topoisomerase I inhibitor that induces DNA double strand breaks, leading to growth arrest and apoptosis. Consequently, VV has been engineered to express a more effective isoform of the CE enzyme. The virus’ tumour tropism should restrict en

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9

Grobler, Anne Frederica. "Pharmaceutical applications of PheroidTM technology / Anne F. Grobler." Thesis, North-West University, 2009. http://hdl.handle.net/10394/6701.

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For a drug to have a therapeutic effect, it has to reach its site of action in sufficient quantities. The Pheroid drug delivery system enhances the absorption of drugs in various pharmacological categories and is the focus of this study. A number of patents are registered in various countries to protect its application. Pheroid technology is trademarked, but may for ease of reading, be called Pheroid(s) only. The Pheroid itself is composed of an organic carbon backbone composed of unsaturated fatty acids with some side-chain interactions that result in self-emulsifying characteristics. The res

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10

Bourdages, Nadia. "Vaccins à base de plante comme alternatives aux antibiotiques : évaluation du potentiel d'un extrait de tabac contenant rFaeGntd/dsc d’Escherichia coli entérotoxigénique (ETEC) à induire une réponse immunitaire chez le procelet sevré." Mémoire, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/9792.

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La diarrhée post-sevrage causée par Escherichia coli entérotoxigénique présentant le fimbriae F4 (ETEC F4+) cause actuellement des pertes économiques importantes dans l’industrie porcine canadienne. Afin de mieux contrôler cette maladie, et afin d’offrir une alternative à l’utilisation excessive d’antibiotiques, le projet décrit dans ce mémoire évalue la capacité de la sous-unité majeure du fimbriae F4, FaeG, à protéger les porcelets contre ETEC F4+. Trois phases animales ont été réalisées afin de tester séparément et de façon combinée l’effet de FaeG sous forme d’émulsion orale et sous forme

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11

Shakweh, Monjed. "Contribution à l'étude des paramètres contrôlant le devenir de particules biodégradables après administration orale." Paris 11, 2005. http://www.theses.fr/2005PA114812.

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Dans cette étude, les propriétés physico-chimiques des particules biodégradables (taille et nature de surface) contrôlant leur devenir après administration orale ont été étudiées. Les particules de taille ≤ 1 μm sont captées plus efficacement de celles de plus grande taille. Les particules chargées négativement ont une meilleure capture que celles de charge positive. Une stratégie de suicide cellulaire utilisant des particules contenant une molécule cytotoxique (le clodronate) a montré que ce sont les macrophages des PPs qui seraient responsables de la capture des particules après leur trancyt

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12

"Plague vaccine: Homologous and heterologous prime-boost strategies using recombinant Yersinia pestis proteins." Tulane University, 2005.

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Yersinia pestis has been identified as a potential agent of biological warfare or bioterrorism and presents a particular challenge to vaccine developers because of the severity and potential transmissibility of the pneumonic form of the disease in humans. A Y. pestis-derived fusion protein (F1-V) has shown great promise as a protective antigen in murine studies. Here, initial studies were done to examine the ability of different prime-boost regimens, including parenteral, mucosal, and transcutaneous delivery, to induce a specific immune response of high titer and long duration. Next, we examin

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13

TAYE, KISSI JIMMA. "VACCINE DEVELOPMENT AGAINST PLAGUE, GLANDERS AND MELIOIDOSIS IN THE FORMER SOVIET UNION IN COMPARSION TO THE CURRENT STATE OF GLOBAL KNOWLEDGE." Doctoral thesis, 2009. https://ul.qucosa.de/id/qucosa%3A11019.

Full text

Abstract:

The causative agents of plague (Y. pestis), glanders (B. mallei) and melioidosis (B. pseudomallei) are included in critical agents of bioterrorisim. They belong to the most intensively studied agents during cold war, specially in the former Soviet Union (FSU). Mostly what is known about these agents, particularly (Y. pestis ) is not available in English language publications. Many of the studies are written in Russian language and published in Russian scientific journals. Thus, the work is designed to evaluate, published and unpublished Russian language written data obtained, in comparisions t

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14

Taye, Kissi Jimma [Verfasser]. "Vaccine development against plague, glanders and melioidosis in the former Soviet Union in comparsion to the current state of global knowledge / submitted by Taye Kissi Jimma." 2009. http://d-nb.info/1006895752/34.

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15

Bergeron, Sandoval Louis-Philippe. "Expression de protéines du rotavirus humain chez les plantes et leur utilisation pour une stimulation immunitaire chez la souris." Mémoire, 2009. http://www.archipel.uqam.ca/3367/1/M11204.pdf.

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Au niveau de la santé publique, l'impact meurtrier des infections au rotavirus humain (RVH) et les limites d'application des vaccins disponibles déterminent l'urgence et la nécessité de développer de nouvelles approches pour immuniser une grande partie de la population mondiale sans effets secondaires néfastes. Pour pallier à l'énorme demande en médicaments et en vaccins, plusieurs groupes de recherche tentent de développer de nouvelles méthodes de production à base de plantes transgéniques. La production de médicaments et vaccins chez les végétaux possèdent des avantages inhérents dont une ab

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16

Khanna, Mayank. "The role of heparan sulfate in poxvirus infections." Phd thesis, 2015. http://hdl.handle.net/1885/101515.

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The heparan sulfate (HS) component of heparan sulfate proteoglycans (HSPGs) has been implicated in the initiation of several viral infections, including vaccinia virus (VACV). A cell infected with VACV releases two different forms of VACV, namely the mature virus (MV) released following the death of infected cells and which infects neighbouring cells, and the enveloped virus (EV) ejected from infected cells for long-range dissemination. The relative role of HS in the infectivity of the different forms of VACV is unclear. Furthermore, there is little known about the fine specificity of t

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