Academic literature on the topic 'Plant autophagy'

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Journal articles on the topic "Plant autophagy"

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Luo, Shuwei, Xifeng Li, Yan Zhang, et al. "Cargo Recognition and Function of Selective Autophagy Receptors in Plants." International Journal of Molecular Sciences 22, no. 3 (2021): 1013. http://dx.doi.org/10.3390/ijms22031013.

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Autophagy is a major quality control system for degradation of unwanted or damaged cytoplasmic components to promote cellular homeostasis. Although non-selective bulk degradation of cytoplasm by autophagy plays a role during cellular response to nutrient deprivation, the broad roles of autophagy are primarily mediated by selective clearance of specifically targeted components. Selective autophagy relies on cargo receptors that recognize targeted components and recruit them to autophagosomes through interaction with lapidated autophagy-related protein 8 (ATG8) family proteins anchored in the me
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Wang, Song, Weiming Hu, and Fen Liu. "Autophagy in the Lifetime of Plants: From Seed to Seed." International Journal of Molecular Sciences 23, no. 19 (2022): 11410. http://dx.doi.org/10.3390/ijms231911410.

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Autophagy is a highly conserved self-degradation mechanism in eukaryotes. Excess or harmful intracellular content can be encapsulated by double-membrane autophagic vacuoles and transferred to vacuoles for degradation in plants. Current research shows three types of autophagy in plants, with macroautophagy being the most important autophagic degradation pathway. Until now, more than 40 autophagy-related (ATG) proteins have been identified in plants that are involved in macroautophagy, and these proteins play an important role in plant growth regulation and stress responses. In this review, we m
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Ran, Jie, Sayed M. Hashimi, and Jian-Zhong Liu. "Emerging Roles of the Selective Autophagy in Plant Immunity and Stress Tolerance." International Journal of Molecular Sciences 21, no. 17 (2020): 6321. http://dx.doi.org/10.3390/ijms21176321.

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Autophagy is a conserved recycling system required for cellular homeostasis. Identifications of diverse selective receptors/adaptors that recruit appropriate autophagic cargoes have revealed critical roles of selective autophagy in different biological processes in plants. In this review, we summarize the emerging roles of selective autophagy in both biotic and abiotic stress tolerance and highlight the new features of selective receptors/adaptors and their interactions with both the cargoes and Autophagy-related gene 8s (ATG8s). In addition, we review how the two major degradation systems, na
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Gao, Caiji, Xiaohong Zhuang, Yong Cui, et al. "Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation." Proceedings of the National Academy of Sciences 112, no. 6 (2015): 1886–91. http://dx.doi.org/10.1073/pnas.1421271112.

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Protein turnover can be achieved via the lysosome/vacuole and the autophagic degradation pathways. Evidence has accumulated revealing that efficient autophagic degradation requires functional endosomal sorting complex required for transport (ESCRT) machinery. However, the interplay between the ESCRT machinery and the autophagy regulator remains unclear. Here, we show that FYVE domain protein required for endosomal sorting 1 (FREE1), a recently identified plant-specific ESCRT component essential for multivesicular body (MVB) biogenesis and plant growth, plays roles both in vacuolar protein tran
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Zhang, Ruonan, Tengfei Wang, Yu Cheng, et al. "Rice stripe mosaic virus M protein antagonizes G-protein-induced antiviral autophagy in insect vectors." PLOS Pathogens 21, no. 4 (2025): e1013070. https://doi.org/10.1371/journal.ppat.1013070.

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In the field, 80% of plant viruses are transmitted by insect vectors. When ingested by a sap-sucking insect such as Recilia dorsalis, persistently transmitted viruses such as rice stripe mosaic virus (RSMV) infect the gut epithelium and eventually pass to the salivary glands where they will be transmitted to the next rice (Oryza sativa) plant. To efficiently exploit insect vectors for transmission, plant viruses must overcome various immune mechanisms within the vectors, including autophagy. However, understanding how plant viruses overcome insect autophagic defenses remains limited. In this s
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Wleklik, Karolina, and Sławomir Borek. "Vacuolar Processing Enzymes in Plant Programmed Cell Death and Autophagy." International Journal of Molecular Sciences 24, no. 2 (2023): 1198. http://dx.doi.org/10.3390/ijms24021198.

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Vacuolar processing enzymes (VPEs) are plant cysteine proteases that are subjected to autoactivation in an acidic pH. It is presumed that VPEs, by activating other vacuolar hydrolases, are in control of tonoplast rupture during programmed cell death (PCD). Involvement of VPEs has been indicated in various types of plant PCD related to development, senescence, and environmental stress responses. Another pathway induced during such processes is autophagy, which leads to the degradation of cellular components and metabolite salvage, and it is presumed that VPEs may be involved in the degradation
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Zeng, Yonglun, Baiying Li, Changyang Ji, et al. "A unique AtSar1D-AtRabD2a nexus modulates autophagosome biogenesis in Arabidopsis thaliana." Proceedings of the National Academy of Sciences 118, no. 17 (2021): e2021293118. http://dx.doi.org/10.1073/pnas.2021293118.

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In eukaryotes, secretory proteins traffic from the endoplasmic reticulum (ER) to the Golgi apparatus via coat protein complex II (COPII) vesicles. Intriguingly, during nutrient starvation, the COPII machinery acts constructively as a membrane source for autophagosomes during autophagy to maintain cellular homeostasis by recycling intermediate metabolites. In higher plants, essential roles of autophagy have been implicated in plant development and stress responses. Nonetheless, the membrane sources of autophagosomes, especially the participation of the COPII machinery in the autophagic pathway
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Kang, Yuanrong, Wenwu Lin, and Peter D. Nagy. "Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy." PLOS Pathogens 20, no. 3 (2024): e1012085. http://dx.doi.org/10.1371/journal.ppat.1012085.

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Elaborate viral replication organelles (VROs) are formed to support positive-strand RNA virus replication in infected cells. VRO formation requires subversion of intracellular membranes by viral replication proteins. Here, we showed that the key ATG8f autophagy protein and NBR1 selective autophagy receptor were co-opted by Tomato bushy stunt virus (TBSV) and the closely-related carnation Italian ringspot virus. Knockdown of ATG8f or NBR1 in plants led to reduced tombusvirus replication, suggesting pro-viral function for selective autophagy. BiFC and proximity-labeling experiments showed that t
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Elander, Pernilla H., Sanjana Holla, Igor Sabljić, et al. "Interactome of Arabidopsis ATG5 Suggests Functions beyond Autophagy." International Journal of Molecular Sciences 24, no. 15 (2023): 12300. http://dx.doi.org/10.3390/ijms241512300.

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Autophagy is a catabolic pathway capable of degrading cellular components ranging from individual molecules to organelles. Autophagy helps cells cope with stress by removing superfluous or hazardous material. In a previous work, we demonstrated that transcriptional upregulation of two autophagy-related genes, ATG5 and ATG7, in Arabidopsis thaliana positively affected agronomically important traits: biomass, seed yield, tolerance to pathogens and oxidative stress. Although the occurrence of these traits correlated with enhanced autophagic activity, it is possible that autophagy-independent role
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Wleklik, Karolina, Szymon Stefaniak, Katarzyna Nuc, Małgorzata Pietrowska-Borek, and Sławomir Borek. "Identification and Potential Participation of Lipases in Autophagic Body Degradation in Embryonic Axes of Lupin (Lupinus spp.) Germinating Seeds." International Journal of Molecular Sciences 25, no. 1 (2023): 90. http://dx.doi.org/10.3390/ijms25010090.

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Autophagy is a fundamental process for plants that plays a crucial role in maintaining cellular homeostasis and promoting survival in response to various environmental stresses. One of the lesser-known stages of plant autophagy is the degradation of autophagic bodies in vacuoles. To this day, no plant vacuolar enzyme has been confirmed to be involved in this process. On the other hand, several enzymes have been described in yeast (Saccharomyces cerevisiae), including Atg15, that possess lipolytic activity. In this preliminary study, which was conducted on isolated embryonic axes of the white l
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Dissertations / Theses on the topic "Plant autophagy"

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Ballhaus, Florentine. "Investigating plant autophagy with new chemical modulators." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-428075.

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Autophagy is a major catabolic pathway in which cell components get sequestered in a double membrane vesicle, transported to the vacuole, degraded by vacuolar hydrolases and recycled.  Through this process, cells ensure cell homeostasis and remobilise nutrients. The autophagic flux can be enhanced as an adaptive stress response, improving plants resistance against stress, reducing aging and ultimately increasing yield. However, autophagy regulation in plants remains poorly understood.  Novel plant-specific modulators can be used in a chemical genetic approach for identification of proteins inv
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Testi, Serena. "L’effecteur Avh195 de Phytophthora parasitica : antagoniste de l’autophagie chez l’hôte et promoteur du processus infectieux." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2018. http://theses.univ-cotedazur.fr/2018AZUR4087.

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L’agent pathogène Phytophthora parasitica est un oomycète qui a des effets dévastateurs sur l’agriculture et les écosystèmes naturels. En tant qu'organisme hémi-biotrophe, il infecte les racines des plantes en établissant d'abord un contact intime avec les cellules hôtes (biotrophie) avant de les tuer (nécrotrophie) et de terminer son cycle d'infection. Pour contrôler ces processus, les oomycètes sécrètent des protéines effectrices, qui sont internalisées dans les cellules végétales par un motif de translocation (appelé RxLR-EER) pour manipuler la physiologie et les réponses immunitaires de l'
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Gomez, Rodrigo Enrique. "Unravelling the contribution of lipids in plant autophagy : Identification and functional characterization of lipids implicated in the autophagic process in Arabidopsis." Thesis, Bordeaux, 2021. http://www.theses.fr/2021BORD0103.

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Les plantes, étant des organismes sessiles, sont fréquemment confrontées à une grande variété de stress environnementaux. Ces conditions peuvent conduire à l'accumulation d'agrégats de protéines ou au disfonctionnement de multiples organites intracellulaires. Pour faire face à ces conditions, les plantes ont mis au point des mécanismes d'adaptation sophistiqués qui permettent le recyclage des composants intracellulaires. Ces mécanismes sont essentiels pour les remodelages métaboliques nécessaires à un recyclage efficace des nutriments ainsi qu'à l'élimination des composants nocifs pour la cell
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Testi, Serena. "L’effecteur Avh195 de Phytophthora parasitica : antagoniste de l’autophagie chez l’hôte et promoteur du processus infectieux." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4087/document.

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L’agent pathogène Phytophthora parasitica est un oomycète qui a des effets dévastateurs sur l’agriculture et les écosystèmes naturels. En tant qu'organisme hémi-biotrophe, il infecte les racines des plantes en établissant d'abord un contact intime avec les cellules hôtes (biotrophie) avant de les tuer (nécrotrophie) et de terminer son cycle d'infection. Pour contrôler ces processus, les oomycètes sécrètent des protéines effectrices, qui sont internalisées dans les cellules végétales par un motif de translocation (appelé RxLR-EER) pour manipuler la physiologie et les réponses immunitaires de l'
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Fancy, Nurun Nahar. "Role of S-nitrosylation in plant salt stress." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/29509.

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Salinity stress is one of the main challenges for crop growth and production. The estimated loss of crop yield due to salinity stress is up to 20% worldwide each year. Plants have evolved an array of mechanisms to defend themselves against salinity stress. A key aspect of plant responses to salinity stress is the engagement of a nitrosative burst that results in nitric oxide (NO) accumulation. A major mechanism for the transfer of NO bioactivity is S-nitrosylation which is a modification of the reactive thiol group of a rare but highly active cysteine residue within a protein through the addit
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Sumita, Takuya. "Studies on intracellular protein degradation pathways in plant fungal pathogens." Kyoto University, 2019. http://hdl.handle.net/2433/242706.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21829号<br>農博第2342号<br>新制||農||1068(附属図書館)<br>学位論文||H31||N5201(農学部図書室)<br>京都大学大学院農学研究科地域環境科学専攻<br>(主査)教授 田中 千尋, 教授 本田 与一, 准教授 刑部 正博<br>学位規則第4条第1項該当
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Puleston, Daniel. "The role of autophagy in CD8plus T cell immunity." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:6cc5b853-4899-4de2-8924-71f7ee0659a1.

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Okemo, Pauline Asami. "Regulation of plant programmed cell death by energy metabolism in the Australian resurrection grass Tripogon loliiformis." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/205617/1/Pauline_Okemo_Thesis.pdf.

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Recent studies have shown that T.loliiformis, a resurrection grass, may use the tight regulation of PCD pathways like autophagy to facilitate desiccation tolerance. The aim of this project was to further investigate the mechanisms that T.loliiformis use to suppress PCD and survive prolonged periods of water deficit. This study provides additional insight on how T.loliiformis attains desiccation tolerance that significantly contributes to our knowledge on the pathways and mechanisms used by resurrection plants. The findings from this study will hopefully be employed to harness drought tolerant
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Zhang, Zhu. "Exploration of the anticancer mechanisms of novel chemotherapeutic adjuvants involving autophagy and immune system reprogramming in the treatment of pancreatic cancer." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/755.

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Pancreatic cancer is known to be one of the most life-threatening cancers characterized by aggressive local invasion and distant metastasis. The high basal level of autophagy in pancreatic cancer may be responsible for the low chemotherapeutic drug response rate and poor disease prognosis. However, the clinical application of autophagy inhibitors was unsatisfactory due to their toxicity and minimal single-agent anticancer efficacy. Hence, oncologists begin to consider the tumor microenvironment when exploring new drug targets. In the present study, the anti-tumorigenic mechanisms of two major
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Milani, Manuela. "Cell stress response and hypoxia in breast cancer." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:74d3bf91-9888-4e9e-b5e1-7d5d2d476174.

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During severe hypoxia (<0.01% oxygen) the protein folding machinery becomes dysfunctional, resulting in the accumulation of unfolded proteins with consequent endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) and autophagy, a process involved in the physiological turnover of cytoplasmic components. The link between the UPR and autophagy is not clearly defined. The aim of this thesis is to investigate the role of the induction of UPR under severe hypoxia in tumour survival and resistance to therapy. The results of this research suggest that the activating tr
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Books on the topic "Plant autophagy"

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Carter, Melany. Vegetarian Meal Prep Cookbook : 6 BOOKS in 1: Healthy Meal Prep - Plant Based High Protein Cookbook - Plant Based Keto - Autophagy & Intermittent Fasting - Intermittent Fasting - Compulsive Overeating. Independently Published, 2020.

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Bassham, Diane C., and Jose L. Crespo, eds. Autophagy in plants and algae. Frontiers Media SA, 2015. http://dx.doi.org/10.3389/978-2-88919-477-3.

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Plumb, Dorothy. Anti-Inflammatory Diet Cookbook: An Easy Meal Plan for Beginners with Plant Based, Alkaline Diet and Autophagy to Heal the Immune System, Eliminate Inflammation, Lose Weight and Improve Your Health. Independently Published, 2019.

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Going Green and Money vs. Healthcare: The Truth about Big Pharma and Vaccines, Why Sickness and Obesity Are Losing Against Autophagy, Essential Oils, Plant-Based Medicine and Anti-Inflammatory Cheat Codes. Independently Published, 2021.

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Stephens, Chantel. Mediterranean Diet for Beginners, Plant Based Diet, Intermittent Fasting for Women, Keto Snacks, Autophagy, Ketogenic Bread : 6 Books in 1: The Complete Guide for Weightloss! Great to Listen in a Car! Independently Published, 2019.

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Phenix, Alexander. Hormone Reset Diet 2 in 1 Value Bundle: Hormone Reset Diet + Autophagy - #1 Beginner's Guide to Lose Weight + 21 Days Hormone-Meal Plans. Independently Published, 2019.

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Ramos, Jason. Intermittent Fasting Diabetes: Change Your Habits and Learn How Autophagy and Keto Diet Can Help You Lose Weight. a Complete 101 Guide for Women and Men with Easy Meal Plans . Independently Published, 2020.

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Tower, Brent. Essential Guide to Autophagy : Learn the Best Strategies to Unlock Your Body's Natural Repair Mechanism to Weight Loss and Healing with Intermittent Fasting: Bonus 7 Day Meal Plans for Intermittent Fasting. Independently Published, 2019.

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Ramos, Jason. Intermittent Fasting Diabetes: Prevent and Reverse Diabetes and Learn How Autophagy and Keto Diet Can Help You Lose Weight. a Complete 101 Guide for Women and Men with Easy Meal Plans. Independently Published, 2019.

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Flores, Melany. Intermittent Fasting: Complete Step-By-Step Guide to Lose Weight Quickly, Slow Aging and Increase Quality of Life Through the Process of Autophagy. Meal Plans with More Than 80 Delicious Recipes! Independently Published, 2019.

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Book chapters on the topic "Plant autophagy"

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Zeng, Hong-Yun, Ping Zheng, Ling-Yan Wang, He-Nan Bao, Sunil Kumar Sahu, and Nan Yao. "Autophagy in Plant Immunity." In Advances in Experimental Medicine and Biology. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0606-2_3.

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Chen, Liang, Faqiang Li, and Shi Xiao. "Analysis of Plant Autophagy." In Methods in Molecular Biology. Springer New York, 2017. http://dx.doi.org/10.1007/978-1-4939-7262-3_24.

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Rodríguez, Milagros Collados, Katarzyna Zientara-Rytter, and Agnieszka Sirko. "Role of Autophagy in Plant Nutrient Deficiency." In Plant Ecophysiology. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-10635-9_7.

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Cui, Xuefei, Jing Zheng, Jinxin Zheng, and Qingqiu Gong. "Study of Autophagy in Plant Senescence." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7672-0_23.

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Floyd, Brice E., Yunting Pu, Junmarie Soto-Burgos, and Diane C. Bassham. "To Live or Die: Autophagy in Plants." In Plant Programmed Cell Death. Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-21033-9_11.

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Seay, Montrell, Andrew P. Hayward, Jeffrey Tsao, and S. P. Dinesh-Kumar. "Something Old, Something New: Plant Innate Immunity and Autophagy." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00302-8_14.

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Husen, Azamal. "Cross Talk Between Autophagy and Hormones for Abiotic Stress Tolerance in Plants." In Plant Performance Under Environmental Stress. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-78521-5_1.

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Papini, Alessio. "Investigation of Morphological Features of Autophagy During Plant Programmed Cell Death." In Methods in Molecular Biology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7668-3_2.

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Ashrafizadeh, Milad, Shima Tavakol, Reza Mohammadinejad, et al. "Paving the Road Toward Exploiting the Therapeutic Effects of Ginsenosides: An Emphasis on Autophagy and Endoplasmic Reticulum Stress." In Pharmacological Properties of Plant-Derived Natural Products and Implications for Human Health. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64872-5_12.

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Laureano-Marín, Ana M., Inmaculada Moreno, Ángeles Aroca, Irene García, Luis C. Romero, and Cecilia Gotor. "Regulation of Autophagy by Hydrogen Sulfide." In Gasotransmitters in Plants. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40713-5_3.

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Conference papers on the topic "Plant autophagy"

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Peththa Thanthrige, Nipuni. "AtBAG4 interacts with NBR1 to promote chaperone-mediated autophagy and stress tolerance." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1052976.

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Akintayo, Oluwatoyosi F. "The Arabidopsis plasma membrane PSS1 protein conferring nhost immunity contributes to defense through autophagy following infection." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1053055.

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Yu, PEIFENG. "Dynamic Activity Regulation of the Ubiquitin-26S Proteasome System and Autophagy is Essential for Proper Seed Development." In ASPB PLANT BIOLOGY 2020. ASPB, 2020. http://dx.doi.org/10.46678/pb.20.1049094.

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Rabadanova, K. K., E. V. Tyutereva, K. S. Dobryakova, and O. V. Voitsekhovskaja. "The potassium role in the autophagy induction in salt stress in Arabidopsis thaliana." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-370.

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Murtuzova, A. V., K. K. Rabadanova, K. S. Dobryakova, E. V. Tyutereva, and O. V. Voitsekhovskaja. "The role of potassium in the regulation of constitutive and stress-induced autophagy in plants." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future. Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-299.

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Minibayeva, F. V. "OXIDATIVE STRESS AND AUTOPHAGY IN PLANT CELLS: THE ROLE OF MITOCHONDRIA." In The Second All-Russian Scientific Conference with international participation "Regulation Mechanisms of Eukariotic Cell Organelle Functions". SIPPB SB RAS, 2018. http://dx.doi.org/10.31255/978-5-94797-318-1-65-65.

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Apollonov, V. I. "Regulation of autophagy, cell death and growth under salt stress in barley varieties with different salt tolerance." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-47.

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Zharova, D. A., A. I. Evkaykina, O. N. Boldina, O. V. Voitsekhovskaja, and E. V. Tyutereva. "Study of the role of autophagy in stress resistance and activation of astaxanthin biosynthesis in the microalga Haematococcus pluvialis." In IX Congress of society physiologists of plants of Russia "Plant physiology is the basis for creating plants of the future". Kazan University Press, 2019. http://dx.doi.org/10.26907/978-5-00130-204-9-2019-169.

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Sasanuma, I., N. Suzuki, and K. Saito. "Rose essential oils stimulate neural differentiation and autophagy in stem cells." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400081.

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Wang, Xin-Ru. "The roles of autophagy in the interactions of a whitefly with a plant virus it transmits." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.112405.

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Reports on the topic "Plant autophagy"

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Dickman, Martin B., and Oded Yarden. Genetic and chemical intervention in ROS signaling pathways affecting development and pathogenicity of Sclerotinia sclerotiorum. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7699866.bard.

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Abstract: The long-term goals of our research are to understand the regulation of sclerotial development and pathogenicity in S. sclerotior11111. The focus in this project was on the elucidation of the signaling events and environmental cues involved in the regulation of these processes, utilizing and continuously developing tools our research groups have established and/or adapted for analysis of S. sclerotiorum, Our stated objectives: To take advantage of the recent conceptual (ROS/PPs signaling) and technical (amenability of S. sclerotiorumto manipulations coupled with chemical genomics and
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