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Journal articles on the topic 'Plant-Based Antifungals'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Arockianathan, P. Marie, Monika Mishra, and Rituraj Niranjan. "Recent Status and Advancements in the Development of Antifungal Agents: Highlights on Plant and Marine Based Antifungals." Current Topics in Medicinal Chemistry 19, no. 10 (2019): 812–30. http://dx.doi.org/10.2174/1568026619666190412102037.

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The developing resistance in fungi has become a key challenge, which is being faced nowadays with the available antifungal agents in the market. Further search for novel compounds from different sources has been explored to meet this problem. The current review describes and highlights recent advancement in the antifungal drug aspects from plant and marine based sources. The current available antifungal agents act on specific targets on the fungal cell wall, like ergosterol synthesis, chitin biosynthesis, sphingolipid synthesis, glucan synthesis etc. We discuss some of the important anti-funga

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Khalifa, Hazim O., Atef Oreiby, Mohamed A. A. Abdelhamid, Mi-Ran Ki, and Seung Pil Pack. "Biomimetic Antifungal Materials: Countering the Challenge of Multidrug-Resistant Fungi." Biomimetics 9, no. 7 (2024): 425. http://dx.doi.org/10.3390/biomimetics9070425.

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In light of rising public health threats like antifungal and antimicrobial resistance, alongside the slowdown in new antimicrobial development, biomimetics have shown promise as therapeutic agents. Multidrug-resistant fungi pose significant challenges as they quickly develop resistance, making traditional antifungals less effective. Developing new antifungals is also complicated by the need to target eukaryotic cells without harming the host. This review examines biomimetic antifungal materials that mimic natural biological mechanisms for targeted and efficient action. It covers a range of age

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Shahina, Zinnat, Ragothaman M. Yennamalli, and Tanya E. S. Dahms. "Anti-virulence activity of plant-based antifungals through microtubule inhibition." Biophysical Journal 121, no. 3 (2022): 112a. http://dx.doi.org/10.1016/j.bpj.2021.11.2137.

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Mauludi, M. Ridha, Harry Widjajanti, and Elisa Nurnawati. "POTENTIAL OF ACTIVE COMPOUNDS LEAVES OF MANGO PARASITE (Dendrophthoe pentandra (L). Miq) AS ANTIFUNGAL." BIOVALENTIA: Biological Research Journal 8, no. 1 (2022): 61–68. http://dx.doi.org/10.24233/biov.8.1.2022.245.

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Infection is a disease that is easily found in tropical areas such as Indonesia. The causes of infection that are easily found include infections due to fungi. One of the fungi that causes many infections is the Candida fungus. Tropical drugs commonly used to treat cutaneous candidiasis include nystatin, clotrimazole, miconazole, ketoconazole and other azoles. However, antifungal drugs have limitations, such as severe side effects, poor penetration into certain tissues, and the emergence of resistance. To overcome the negative effects caused by these synthetic antifungal drugs, it is necessary

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Cobos, Rebeca, Rosa María Mateos, José Manuel Álvarez-Pérez, et al. "Effectiveness of Natural Antifungal Compounds in Controlling Infection by Grapevine Trunk Disease Pathogens through Pruning Wounds." Applied and Environmental Microbiology 81, no. 18 (2015): 6474–83. http://dx.doi.org/10.1128/aem.01818-15.

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ABSTRACTGrapevine trunk fungal pathogens, such asDiplodia seriataandPhaeomoniella chlamydospora, can infect plants through pruning wounds. They cause grapevine trunk diseases and are involved in grapevine decline. Accordingly, the protection of pruning wounds is crucial for the management of grapevine trunk diseases. The efficacy of different natural antifungals in inhibiting the growth of several fungi causing grapevine trunk diseases was evaluatedin vitro. The fungi showing greaterin vitroefficacy were tested on autoclaved grape wood assays againstD. seriataandP. chlamydospora. Based on resu

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Hazarika, Jonardan, Atlanta Kalita, Prachujya Gogoi, et al. "A Comprehensive Review of Plant Based Extracts for Preventing and Controlling Candida albicans." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 21 (2024): 253–65. http://dx.doi.org/10.56557/upjoz/2024/v45i214634.

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A common fungal pathogen Candida albicans can cause infections ranging from simple mucosal infections to serious systemic illnesses especially in people with weakened immune systems. Normally found in the human microbiome it turns harmful when the immune system is weakened. Its dimorphism—the capacity to transition between hyphal, and yeast forms—is a primary factor contributing to its pathogenicity, and is essential for both tissue penetration, and dissemination. This transition is crucial for tissue invasion, biofilm formation, and dissemination within the host. The infection mechanism invol

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Cely-Veloza, Willy, Diego Quiroga, and Ericsson Coy-Barrera. "Quinolizidine-Based Variations and Antifungal Activity of Eight Lupinus Species Grown under Greenhouse Conditions." Molecules 27, no. 1 (2022): 305. http://dx.doi.org/10.3390/molecules27010305.

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Fusarium oxysporum is an aggressive phytopathogen that affects various plant species, resulting in extensive local and global economic losses. Therefore, the search for competent alternatives is a constant pursuit. Quinolizidine alkaloids (QA) are naturally occurring compounds with diverse biological activities. The structural diversity of quinolizidines is mainly contributed by species of the family Fabaceae, particularly the genus Lupinus. This quinolizidine-based chemo diversity can be explored to find antifungals and even mixtures to address concomitant effects on F. oxysporum. Thus, the a

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Fernandes, Viton Dyrk Guimarães, Ana Beatriz Bomfim Gomes Ribeiro, Lara Mayanne Moreira de Oliveira Nóbrega, et al. "Evaluation of the Antifungal Activity of the Methanolic Extract of Psidium Guineense (Myrtaceae) Against Strains of the Genus Candida." European Journal of Medical and Health Sciences 5, no. 5 (2023): 105–9. http://dx.doi.org/10.24018/ejmed.2023.5.5.1914.

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Candidiasis is the most common fungal infection of the oral cavity, and its etiological factor is the proliferation and growth of microorganisms of the genus Candida. Candida fungi make up the diverse microbiota of the oral cavity living in a harmless commensal relationship with the host and can colonise different habitats such as mucous membranes and skin. Several antifungal drugs have been used for the treatment of candidiasis, such as azole antifungals (ketoconazole, fluconazole) and polyene antifungals (nystatin, amphotericin B), however, several challenges have been observed regarding the

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Costa, Jéssica, Marcela Sepúlveda, Víctor Gallardo, et al. "Antifungal Potential of Capsaicinoids and Capsinoids from the Capsicum Genus for the Safeguarding of Agrifood Production: Advantages and Limitations for Environmental Health." Microorganisms 10, no. 12 (2022): 2387. http://dx.doi.org/10.3390/microorganisms10122387.

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Opportunistic pathogenic fungi arise in agricultural crops as well as in surrounding human daily life. The recent increase in antifungal-resistant strains has created the need for new effective antifungals, particularly those based on plant secondary metabolites, such as capsaicinoids and capsinoids produced by Capsicum species. The use of such natural compounds is well-aligned with the One Health approach, which tries to find an equilibrium among people, animals, and the environment. Considering this, the main objective of the present work is to review the antifungal potential of capsaicinoid

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Oniha, M. I., A. O. Eni, O. O. Akinnola, et al. "In vivo Evaluation of Plant Extracts against Common Phytopathogenic Fungi Isolated from Pawpaw (Carica papaya L.)." IOP Conference Series: Earth and Environmental Science 1492, no. 1 (2025): 012006. https://doi.org/10.1088/1755-1315/1492/1/012006.

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Abstract Plants possess various efficacious natural products to curtailing various problems associated with man and his environment. Fungi cause significant postharvest losses to global pawpaw (Carica papaya) production, particularly in Africa. Current control methods focus primarily on synthetic fungicides that are hazardous to the environment, while plant-based fungicides are characterised with biofriendly and cost-effective potential. In this study, three plant extracts were investigated for their in vivo antifungal property opposed to three phytopathogenic mycoflora isolated from Carica pa

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Devecioglu, Dilara, Anı Kuscu, and Funda Karbancioglu-Guler. "Isolation and Functional Characterization of Yeasts from Fermented Plant Based Products." Fermentation 11, no. 6 (2025): 305. https://doi.org/10.3390/fermentation11060305.

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Yeasts isolated from fermented plant-based sources—boza, pickles, and chickpeas—were evaluated for probiotic potential. Among 18 colonies, seven isolates showing no hemolytic activity were selected and identified: Pichia kudriavzevii (four isolates), Kazachstania exigua, Hanseniaspora uvarum, and Saccharomyces cerevisiae. Most isolates were able to survive under low pH and bile salt conditions, simulating the environment of the gastrointestinal tract (5.62–8.59 log CFU/mL) and tolerated NaCl concentrations up to 6–8% (w/v). All isolates exhibited antibiotic resistance; however, their susceptib

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Guerra, Rosane Nassar Meireles, Aluísio Silva Oliveira, Josivan Regis Farias, et al. "Anacardiaceae Family: Effect of Isolated Compounds and Other Identified Phytochemicals Against Clinically Relevant Candida Species—A Short Review." Antibiotics 14, no. 3 (2025): 308. https://doi.org/10.3390/antibiotics14030308.

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Background: The increased rates of common fungal diseases are a constant challenge. Therefore, the search for plant-based compounds with antifungal activity, particularly ones against Candida species, is always relevant in the medical context. However, most of the studies have focused on screening the antifungal activity of extracts rather than isolated compounds. Based on this, we aimed to analyze and organize a comprehensive overview of the antifungal and other biological activities of isolated compounds found in Anacardiaceae family vegetal species, covering mechanisms of action and potenti

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Saludares, G. G., C. D. Amper, and I. M. Lituanas. "Antimicrobial performances of Ganoderma lucidum extract against fruits and leaves pathogens." IOP Conference Series: Earth and Environmental Science 1145, no. 1 (2023): 012019. http://dx.doi.org/10.1088/1755-1315/1145/1/012019.

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Abstract Ganoderma lucidum is a rich source of unique compounds and has several properties including antifungals and contains different types of biologically active substances that are effective against different types of plant diseases. Hence, this study was conducted to assess the antimicrobial potential of G. lucidum extract. Ganoderma concentrations [5%, 10%, 15%, 20%, and 100% (pure Ganoderma extract)] were applied using the poison food technique. The different test pathogens were the following: Colletotrichum capsici, Colletotrichum gloeosporioides, Colletotrichum coccodes, Fusarium sp.,

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Widayati, Ratna, Sarah Novita Rahayu, and Helena Jelita. "ANTI-FUNGAL ACTIVITY OF KELAKAI LEAF (Stenochlaena palustris (Burm.f) Bedd)." Jurnal Kesehatan Tambusai 3, no. 2 (2022): 55–61. http://dx.doi.org/10.31004/jkt.v3i2.4257.

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Candidiasis is a fungal infection caused by Candida albicans. The Kenyah Dayak community in East Kalimantan often use kelakai leaf to treat fungal diseases. The plant contains tannins, flavonoids, steroids that have potential as antifungals. This study aimed to determine the antifungal activity of the ethanolic extract of Kelakai Leaf (Stenochlaena palustris (Burm.f.) Bedd). This research is a laboratory experimental research with post test only control group design. The research subjects used Candida albicans culture, with 7 treatment groups, namely ethanolic extract of kelakai leaf with conc

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Alves-Silva, Jorge, Mónica Zuzarte, Carlos Cavaleiro, and Lígia Salgueiro. "Antibiofilm Effect of Lavandula multifida Essential Oil: A New Approach for Chronic Infections." Pharmaceutics 15, no. 8 (2023): 2142. http://dx.doi.org/10.3390/pharmaceutics15082142.

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Fungal infections are associated with high morbidity and mortality rates, being highly prevalent in patients with underlying health complications such as chronic lung disease, HIV, cancer, and diabetes mellitus. To mitigate these infections, the development of effective antifungals is imperative, with plants standing out as promising sources of bioactive compounds. In the present study, we focus on the antibiofilm potential of Lavandula multifida essential oil (EO) against dermatophyte strains and Candida albicans. The EO was characterized using GC and GC–MS, and its antifungal effect was asse

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Angarita-Rodríguez, Andrea, Diego Quiroga, and Ericsson Coy-Barrera. "Indole-Containing Phytoalexin-Based Bioisosteres as Antifungals: In Vitro and In Silico Evaluation against Fusarium oxysporum." Molecules 25, no. 1 (2019): 45. http://dx.doi.org/10.3390/molecules25010045.

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There is a continuous search for more reliable and effective alternatives to control phytopathogens through different strategies. In this context, indole-containing phytoalexins are stimuli-induced compounds implicated in plant defense against plant pathogens. However, phytoalexins’ efficacy have been limited by fungal detoxifying mechanisms, thus, the research on bioisosteres-based analogs can be a friendly alternative regarding the control of Fusarium phytopathogens, but there are currently few studies on it. Thus, as part of our research on antifungal agents, a set of 21 synthetic indole-co

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R. Shaikh, Nishat, and Kashinath G. Choudhary. "FUNGAL KERATITIS - AN UPDATE ON THE GLOBAL THREAT." International Journal of Advanced Research 11, no. 03 (2023): 51–55. http://dx.doi.org/10.21474/ijar01/16390.

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Fungal keratitis (FK) is a sight-threatening disease caused by infection of the cornea by filamentous fungi or yeasts. FK can be challenging to diagnose and treat. In tropical, low, and middle-income countries, it accounts for the majority of cases of microbial keratitis (MK). Filamentous fungi, in particular, Fusarium spp., the aspergilli, and dematiaceous fungi are responsible for the most significant burden of disease. The predominant risk factor for filamentous fungal keratitis is trauma, typically with organic, plant-based material. In 2020, the incidence of FK was estimated to be over 1

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Letsiou, Sophia, Katerina Pyrovolou, Spyros J. Konteles, et al. "Exploring the Antifungal Activity of Various Natural Extracts in a Sustainable Saccharomyces cerevisiae Model Using Cell Viability, Spot Assay, and Turbidometric Microbial Assays." Applied Sciences 14, no. 5 (2024): 1899. http://dx.doi.org/10.3390/app14051899.

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Saccharomyces cerevisiae is a sustainable yeast with many applications in the food industry. Here, we study the use of a Saccharomyces cerevisiae model composed of three different industrial strains (a wine, a beer and a baker’s strain) to assess the antifungal activity of three organic plant-based extracts (Hypericum perforatum 10% w/w, Pistacia lentiscus var. Chia 20% w/w and Rosmarinus officinalis 6% w/w). Three different methods were employed (agar disc diffusion, spot assay, and growth curve analysis). Only the Rosmarinus officinalis extract (6% w/w) exhibited inhibitory activity against

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Leontopoulos, Stefanos, Prodromos Skenderidis, Konstantinos Petrotos, Chrysanthi Mitsagga, and Ioannis Giavasis. "Preliminary Studies on Suppression of Important Plant Pathogens by Using Pomegranate and Avocado Residual Peel and Seed Extracts." Horticulturae 8, no. 4 (2022): 283. http://dx.doi.org/10.3390/horticulturae8040283.

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Potential synergistic action of aqueous extracts of pomegranate peel (PP), avocado peel (AP), and avocado seed (AS) wastes isolated by microwave-assisted extraction were assessed in in vitro and in vivo assays as biocontrol agents against several plant pathogenic fungi. The study findings contribute to the utilization of a value-added industrial byproduct and provide significant value in advancing the development of new plant protecting compositions that benefit from the synergistic effects between two important plant species that contain several natural bioactive compounds. More specifically,

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Álvarez-Caballero, Juan Manuel, and Ericsson Coy-Barrera. "Chemical and Antifungal Variability of Several Accessions of Azadirachta indica A. Juss. from Six Locations Across the Colombian Caribbean Coast: Identification of Antifungal Azadirone Limonoids." Plants 8, no. 12 (2019): 555. http://dx.doi.org/10.3390/plants8120555.

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Plant materials (i.e., leaves, fruits, and seeds) from 40 trees of Azadirachta indica A. Juss. were collected from six different locations across the Colombian Caribbean coast. Eighty-four ethanolic extracts were prepared and the total limonoid contents (TLiC) and the antifungal activity against Fusarium oxysporum conidia were measured. Their chemical profiles were also recorded via liquid chromatography-electrospray ionization interface-mass spectrometry (LC-ESI-MS) analysis and the top-ranked features were then annotated after supervised multivariate statistics. Inter-location chemical varia

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Silva, Kevin Gustavo dos Santos, Gabriela Oliveira do Nascimento, Erik Ernani Marques da Silva, Luiza Helena Virgilio Cabral, Tatiana Mayra Rocha Faria, and Jonatas Rafael de Oliveira. "Candida albicans: Virulence factors, pathogenesis, and ways to diagnose and control its infection." Research, Society and Development 13, no. 1 (2024): e6413144781. http://dx.doi.org/10.33448/rsd-v13i1.44781.

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The objective of this study was to provide a review on Candida albicans, focusing on its main virulence factors, pathogenesis, and methods of diagnosis and control of infections caused by this microorganism, known as candidiasis. Its main virulence factors are adhesion, polymorphism and dimorphism, which aid in tissue invasion, phenotypic variability, tolerance to toxins, and the presence of enzymes such as proteases and phospholipases. These factors confer the fungus with the ability to colonize, establish itself, and consequently, cause infections. C. albicans can proliferate on the skin and

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Aborah, Martin, Frank Scarano, and Catherine Neto. "Gas Chromatography/Mass Spectrometry Chemical Profiling of Volatile Compounds from Cranberry Plant Byproducts as Potential Antibacterials, Antifungals, and Antioxidants." Molecules 30, no. 9 (2025): 2047. https://doi.org/10.3390/molecules30092047.

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The increasing resistance of microorganisms to currently used antimicrobials requires the urgent development of new effective treatments. Plant-based natural products can be an alternative solution. The aerial plant parts of the cranberry (Vaccinium macrocarpon) present a potential new source of antimicrobial secondary metabolites. Volatile essential oils were extracted from Stevens, Early Black, and Mullica Queen variety plants by steam distillation (SD) and the Clevenger method (CM), and their profiles were characterized by GC-MS. The extracts and two identified constituents, cinnamaldehyde

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Springer, Jan, Grit Walther, Volker Rickerts, et al. "Detection of Fusarium Species in Clinical Specimens by Probe-Based Real-Time PCR." Journal of Fungi 5, no. 4 (2019): 105. http://dx.doi.org/10.3390/jof5040105.

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The mold Fusarium is a ubiquitous fungus causing plant, animal and human infections. In humans, Fusarium spp. are the major cause of eye infections in patients wearing contact lenses or after local trauma. Systemic infections by Fusarium spp. mainly occur in immunosuppressed patients and can disseminate throughout the human body. Due to high levels of resistance to antifungals a fast identification of the causative agent is an urgent need. By using a probe-based real-time PCR assay specific for the genus Fusarium we analysed several different clinical specimens detecting Fusarium spp. commonly

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Qureshi, Zaeema, Mohammad Anzar Husain, Altaf Husain Shah, and Atoofa Khalid. "Unani and Modern Perspective to Understanding and Managing Bahaq (Pityriasis Versicolor): A Comprehensive Review." Journal of Drug Delivery and Therapeutics 15, no. 2 (2025): 143–48. https://doi.org/10.22270/jddt.v15i2.7001.

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Pityriasis versicolor (Bahaq) is a chronic, superficial fungal skin infection caused by Malassezia furfur, characterized by hypopigmented or hyperpigmented macules or patches on the upper trunk, neck and shoulders. It predominantly affects adolescents and young adults, particularly in warm and humid climates. Unani medicine identifies Bahaq as a humoral disorder caused by imbalances in phlegm or black bile, which disrupt pigmentation and skin integrity. Esteemed Unani scholars, including Rabban Tabarī, Zakariya Razi, Ibn Sina and Ajmal Khan, have detailed its etiology, pathogenesis and treatme

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Burks, Caroline, Alexandria Darby, Luisa Gómez Londoño, Michelle Momany, and Marin T. Brewer. "Azole-resistant Aspergillus fumigatus in the environment: Identifying key reservoirs and hotspots of antifungal resistance." PLOS Pathogens 17, no. 7 (2021): e1009711. http://dx.doi.org/10.1371/journal.ppat.1009711.

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Aspergillus fumigatus is an opportunistic human pathogen that causes aspergillosis, a spectrum of environmentally acquired respiratory illnesses. It has a cosmopolitan distribution and exists in the environment as a saprotroph on decaying plant matter. Azoles, which target Cyp51A in the ergosterol synthesis pathway, are the primary class of drugs used to treat aspergillosis. Azoles are also used to combat plant pathogenic fungi. Recently, an increasing number of azole-naive patients have presented with pan-azole–resistant strains of A. fumigatus. The TR34/L98H and TR46/Y121F/T289A alleles in t

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Hoffman, Jeremy J., Matthew J. Burton, and Astrid Leck. "Mycotic Keratitis—A Global Threat from the Filamentous Fungi." Journal of Fungi 7, no. 4 (2021): 273. http://dx.doi.org/10.3390/jof7040273.

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Mycotic or fungal keratitis (FK) is a sight-threatening disease, caused by infection of the cornea by filamentous fungi or yeasts. In tropical, low and middle-income countries, it accounts for the majority of cases of microbial keratitis (MK). Filamentous fungi, in particular Fusarium spp., the aspergilli and dematiaceous fungi, are responsible for the greatest burden of disease. The predominant risk factor for filamentous fungal keratitis is trauma, typically with organic, plant-based material. In developed countries, contact lens wear and related products are frequently implicated as risk fa

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Anitha, Devi U., G. Renuka, Venkateshwarlu, and T. *Ugandhar. ""SPOILED COCONUT WATER-INDUCED NEUROTOXICITY: NOVEL INSIGHTS INTO FUNGAL CONTAMINATION, 3-NPA POISONING, PREVENTION, AND PLANT-BASED THERAPIES"." World Journal of Pharmaceutical Science and Research 4, no. 2 (2025): 1071–83. https://doi.org/10.5281/zenodo.15364989.

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Coconut water is a widely consumed natural beverage, prized for its hydration and health benefits. However, recent clinical evidence highlights a rare but life-threatening risk associated with its improper storage. This review centres on a fatal case involving a 69-year-old man in Denmark who developed acute neurotoxic symptoms such as nausea, vomiting, profuse sweating, and brain swelling after consuming coconut water left unrefrigerated for one month. Laboratory analysis confirmed contamination by the fungus <em>Arthrinium saccharicola</em>, which produces 3-nitropropionic acid (3-NPA), a mi

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Buzón-Durán, Laura, Natalia Langa-Lomba, Vicente González-García, et al. "Rutin-stevioside and related conjugates for potential control of grapevine trunk diseases." Phytopathologia Mediterranea 61, no. 1 (2022): 65–77. http://dx.doi.org/10.36253/phyto-13108.

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Flavonoids and phenolic acids play roles in grapevine defence against pathogens causing grapevine trunk diseases (GTDs). Rutin is a major flavonoid in vegetative organs of the grapevines, and this compound, unlike other flavonoids, is non-toxic and non-oxidizable. Rutin was assayed in vitro and in vivo against two Botryosphaeriaceae taxa. The limited bioavailability of this compound was circumvented by conjugation with stevioside, a glycoside obtained from Stevia rebaudiana. Clear synergistic effects were observed for the stevioside-rutin adduct, resulting in EC50 and EC90 values of 306.0 and

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Lanti, Syahrul, Yuliana Retnowati, Novri Youla Kandowangko, Ani M. Hasan, and Abubakar Sidik Katili. "Uji Viabilitas Micromonospora Sp. dari Rhizosfer Tumbuhan di Ekosistem Karts Gorontalo pada Medium Pertumbuhan Beras." MIKHAYLA : Journal of Advanced Research 2, no. 1 (2025): 29–34. https://doi.org/10.61579/mikhayla.v2i1.289.

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Micromonospora sp. are gram-positive actinobacteria native to soil that produce various compounds that support plant growth, including antifungals, biopesticides, and growth hormones that play an important role in root development and nutrient absorption that can be found in various ecosystems with different variations in humidity, pH, and temperature conditions. This study aims to test the viability of micromonospora isolated from the rhizosphere of plants in the Gorontalo karst ecosystem on growth media based on propagation using rice media. This research uses quantitative descriptive method

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Khumaisah, Lela Lailatul, Lela Mukmilah Yuningsih, and Asep Kadarohman. "Pemanfaatan Tanaman Minyak Atsiri Sebagai Pengendali Hama Tikus Padi (Biopestisida) Di Kabupaten Sukabumi." Prosiding Konferensi Nasional Pengabdian Kepada Masyarakat dan Corporate Social Responsibility (PKM-CSR) 2 (December 15, 2019): 243–47. http://dx.doi.org/10.37695/pkmcsr.v2i0.450.

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The chemical content in essential oils have activities on microbes, biopesticides, pathogenic vector insects in humans and animals, including Mentha arvensis and Mentha piperita (mint plants) which have antifertility and antibacterial effects, Vetiveria zizanoides (vetiver root) as insects repellent, Cymbopogon nardus (lemongrass) has an activity against plant pathogenic bacteria and antifungals, and Rosmarinus officinalis (rosemary) has locomotor activity of mice and antibacterial. Essential oils are effective against target organisms, compatible, safe and non-toxic, so they have enormous pot

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El Baz, Soraia, Bouchra Soulaimani, Imane Abbad, et al. "Antimicrobial Activity and the Synergy Potential of Cinnamomum aromaticum Nees and Syzygium aromaticum (L.) Merr. et Perry Essential Oils with Antimicrobial Drugs." Microbiology Research 16, no. 3 (2025): 63. https://doi.org/10.3390/microbiolres16030063.

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Antimicrobial resistance is a growing global challenge, rendering many standard treatments ineffective. Essential oils (EOs) of cinnamon (Cinnamomum aromaticum Nees) and clove (Syzygium aromaticum (L.) Merr. et Perry) may offer an alternative solution due to their high antimicrobial properties and their abilities to fight resistant pathogens. This study evaluates the antimicrobial activity of these two EOs, and their synergistic potential when combined with two antibiotics (ciprofloxacin and vancomycin) and two antifungals (fluconazole and amphotericin B) against various bacterial and yeasts s

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Wijaya, Anas Fadli, Rian Anggia Destiawan, and Nosa Ika Cahyariza. "Antimicrobial Test of Telang Flower Extract (Clitoria ternatea L.) against the Growth of Candida albicans." Prisma Sains : Jurnal Pengkajian Ilmu dan Pembelajaran Matematika dan IPA IKIP Mataram 11, no. 1 (2023): 190. http://dx.doi.org/10.33394/j-ps.v11i1.6857.

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Candidiasis is an acute and subacute fungal infection caused by the Candida group, especially Candida albicans. Infectious diseases due to microbes can be treated using modern drugs, namely antifungals. In some cases, antimicrobials often develop resistance due to improper administration. The occurrence of such resistance encourages further research on new active ingredients that can be used as antimicrobial alternatives, especially from plant sources containing flavonoids. The purpose of this study is to determine the effect of antimicrobial content of ethanol extract 70% of Telang flowers on

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Felizardo, Maria Giullia Alves Carneiro, Ana Patrícia Matos Pereira, Thaylanna Pinto de Lima, et al. "Chemical profile, stability and fungicide activity of oil-in-water nanoemulsion (O / A) incorporated with Ba-har essential oil." Ciência e Natura 43 (June 30, 2021): e57. http://dx.doi.org/10.5902/2179460x63881.

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The increase in strains resistant to conventional antifungals means that there is a need for studies related to alternative therapeutic practices, such as medicinal plants. This study aims to evaluate the chemical profile and fungicidal activity of the nanoemulsion of the essential oil obtained from Ba-har (Syrian pepper). The phytochemical profile of the plant material was performed based on the methodology of Matos (2009). For extraction of essential oil, 100g of plant material was used, with the isolation of essential oil by the hydrodistillation technique conducted at 100 °C / 3h. To quant

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Nair, Jerald J., and Johannes van Staden. "Antifungal Activity Based Studies of Amaryllidaceae Plant Extracts." Natural Product Communications 12, no. 12 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201235.

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The growth in demand for cosmetic, graft and organ transplant surgical procedures, the increased use of antineoplastic and immunosuppressive agents, as well as multidrug resistance are some of the factors responsible for the marked rise in fungal infection rates in recent years. Consequently, there have been renewed calls from both the public and private sectors for new and improved drug targets to replace existing antifungal therapies, many of which have been in clinical circulation for several decades. Plants select themselves in such endeavors owing to their superior numbers and vast chemic

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Andreia Medeiros Rodrigues Cardoso, Yuri Wanderley Cavalcanti, Leopoldina de Fátima Dantas de Almeida, Ana Luíza Alves de Lima Pérez, and Wilton Wilney Nascimento Padilha. "Antifungal activity of plant-based tinctures on Candida." RSBO 9, no. 1 (2013): 25–30. http://dx.doi.org/10.21726/rsbo.v9i1.961.

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To evaluate through determination of minimum inhibitory concentration (MIC) the antifungal activity of Salvia officinalis (sage), Anacardium occidentale (cashew) and Malva sylvestris (mallow) tinctures on Candida albicans (ATCC 40227), C. tropicalis (ATCC 13803) and C. krusei (ATCC 40147). Material and methods: In 96-well microplates, 100 µl of Sabouraud-Dextrose broth doubly concentrated, 100 µl of the tested tinctures and 10 µl of fungal inoculums (1.5 x 106organisms/ml) were inserted. The products were diluted from initial concentration of 100 mg/ml until 0.78 mg/ml. MIC corresponded to the

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Bienvenu, Anne-Lise, Lionel Ballut, and Stephane Picot. "Specifically Targeting Metacaspases of Candida: A New Therapeutic Opportunity." Journal of Fungi 10, no. 2 (2024): 90. http://dx.doi.org/10.3390/jof10020090.

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The World Health Organization (WHO) recently published a list of fungal priority pathogens, including Candida albicans and C. auris. The increased level of resistance of Candida is raising concern, considering the availability of only four classes of medicine. The WHO is seeking novel agent classes with different targets and mechanisms of action. Targeting Candida metacaspases to control intrinsic cell death could provide new therapeutic opportunities for invasive candidiasis. In this review, we provide the available evidence for Candida cell death, describe Candida metacaspases, and discuss t

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Petrović, Elena, Karolina Vrandečić, Sara Godena, and Jasenka Ćosić. "Antifungal activity of plant and compost extracts and preparations based on tree bark." Journal of Central European Agriculture 25, no. 4 (2024): 1024–32. https://doi.org/10.5513/jcea01/25.4.4352.

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Madriz-Ordeñana, Kenneth, Sercan Pazarlar, Hans Jørgen Lyngs Jørgensen, et al. "The Bacillus cereus Strain EC9 Primes the Plant Immune System for Superior Biocontrol of Fusarium oxysporum." Plants 11, no. 5 (2022): 687. http://dx.doi.org/10.3390/plants11050687.

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Antibiosis is a key feature widely exploited to develop biofungicides based on the ability of biological control agents (BCAs) to produce fungitoxic compounds. A less recognised attribute of plant-associated beneficial microorganisms is their ability to stimulate the plant immune system, which may provide long-term, systemic self-protection against different types of pathogens. By using conventional antifungal in vitro screening coupled with in planta assays, we found antifungal and non-antifungal Bacillus strains that protected the ornamental plant Kalanchoe against the soil-borne pathogen Fu

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Deshmane, Prof Mrs Pooja. "Hemidesmus Indicus Used as Potential Antifungal." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 651–55. https://doi.org/10.22214/ijraset.2025.70197.

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Abstract: Hemidesmus indicus, a plant widely used in traditional medicine, has demonstrated potential as a natural antifungal agent. This study explores its efficacy against pathogenic fungi by evaluating various extracts ethanolic, methanolic, and aqueous through in vitro antifungal assays. The results indicated significant inhibitory effects, particularly from the ethanolic extract, against Candida albicans, Aspergillus Niger, and Trichophyton rubrum. Phytochemical analysis revealed the presence of secondary metabolites like flavonoids, alkaloids, and tannins, which are likely responsible fo

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Silva, Flávia dos Santos, Melissa Fontes Landell, Gustavo Vasconcelos Bastos Paulino, Henrique Douglas Melo Coutinho, and Ulysses Paulino Albuquerque. "Antifungal activity of selected plant extracts based on an ethnodirected study." Acta Botanica Brasilica 34, no. 2 (2020): 442–48. http://dx.doi.org/10.1590/0102-33062020abb0003.

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Alghuthaymi, Mousa A., Rajkuberan C., Rajiv P., et al. "Nanohybrid Antifungals for Control of Plant Diseases: Current Status and Future Perspectives." Journal of Fungi 7, no. 1 (2021): 48. http://dx.doi.org/10.3390/jof7010048.

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The changing climatic conditions have led to the concurrent emergence of virulent microbial pathogens that attack crop plants and exhibit yield and quality deterring impacts on the affected crop. To counteract, the widespread infections of fungal pathogens and post-harvest diseases it is highly warranted to develop sustainable techniques and tools bypassing traditional agriculture practices. Nanotechnology offers a solution to the problems in disease management in a simple lucid way. These technologies are revolutionizing the scientific/industrial sectors. Likewise, in agriculture, the nano-ba

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Sarfraz, Muhammad, Muhammad Jawad Nasim, Claus Jacob, and Martin C. H. Gruhlke. "Efficacy of Allicin against Plant Pathogenic Fungi and Unveiling the Underlying Mode of Action Employing Yeast Based Chemogenetic Profiling Approach." Applied Sciences 10, no. 7 (2020): 2563. http://dx.doi.org/10.3390/app10072563.

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Allicin (diallylthiosulfinate) is the principal organosulfur compound present in freshly damaged garlic tissue which exhibits a wide range of biological actions including antibacterial, antifungal, antiviral and anticancer properties. The antifungal activities of allicin were investigated against plant pathogenic fungi of agriculture importance. Furthermore, a yeast genome haploinsufficiency screening was also employed to decipher the antifungal mode of action of allicin. Wildtype and 1152 yeast mutant strains (each deprived of one specific allele of an essential gene in a diploid strain) were

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Surapuram, Venkatasaichaitanya, William N. Setzer, Robert L. McFeeters, and Hana McFeeters. "Antifungal Activity of Plant Extracts against Aspergillus niger and Rhizopus stolonifer." Natural Product Communications 9, no. 11 (2014): 1934578X1400901. http://dx.doi.org/10.1177/1934578x1400901118.

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Despite recent advances in antifungal development, fungi remain a devastating threat to human health and compromise viability of the food supply. Plant based antimicrobials represent a vast untapped source with tremendous potential. Herein we present the antifungal properties of more than 50 plant extracts against two important human and agricultural pathogens, Aspergillus niger and Rhizopus stolonifer. Multiple extracts exhibit promising MIC values of less than 100 μg/mL and are reported for both fungal species.

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Kaur, Navkiranjeet, Aarti Bains, Ravinder Kaushik, Sanju B. Dhull, Fogarasi Melinda, and Prince Chawla. "A Review on Antifungal Efficiency of Plant Extracts Entrenched Polysaccharide-Based Nanohydrogels." Nutrients 13, no. 6 (2021): 2055. http://dx.doi.org/10.3390/nu13062055.

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Human skin acts as a physical barrier; however, sometimes the skin gets infected by fungi, which becomes more severe if the infection occurs on the third layer of the skin. Azole derivative-based antifungal creams, liquids, or sprays are available to treat fungal infections; however, these formulations show various side effects on the application site. Over the past few years, herbal extracts and various essential oils have shown effective antifungal activity. Additionally, autoxidation and epimerization are significant problems with the direct use of herbal extracts. Hence, to overcome these

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Syed, Umme Hani, Taufeeque Shaikh Mohammed, Rahman Shaikh Ibaadur, et al. "Fungal skin disorders and their alleviation using Delonix regia extract." World Journal of Advanced Research and Reviews 24, no. 2 (2024): 819–26. https://doi.org/10.5281/zenodo.15087804.

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Fungal skin disorders, caused by dermatophytes, yeasts, and molds, represent a significant global health concern, affecting millions of people worldwide. These infections often lead to symptoms such as itching, redness, and scaling, and in some cases, can result in chronic conditions if left untreated. Conventional antifungal treatments, while effective, often come with adverse effects, drug resistance, and high treatment costs. As a result, there is a growing interest in exploring alternative, natural remedies. <em>Delonix regia</em> (Royal Poinciana), a tropical plant known for its

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Gadia, Gsel Lorren E., Cromwel M. Jumao-as, and Maria Elena N. Tanabe. "Rhizobacteria in Cyperus iria L.: Elucidating its plant growth-promoting potentials." Rhizobacteria in Cyperus iria L.: Elucidating its plant growth-promoting potentials 2, no. 1 (2020): 23–30. https://doi.org/10.5281/zenodo.8245685.

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Excessive use of synthetic agents in agricultural production entails negative impacts in the environment. Hence, the search for effective and environment-friendly methods is imperative. This study explored the rhizosphere of<em> Cyperus iria</em> L., a common rice weed, for potential plant growth-promoting rhizobacteria. Fifteen rhizobacterial isolates were tested<em> in vitro</em> for plant growth promoting characteristics such as phosphate solubilization, ammonia production, catalase production, and antifungal activity. Phosphate solubilization was tested by plating the isolates on Pikovskay

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Said Shannan Al-Khalasi, Abdullah Saif Al-Ghafri, Suad Nasser Al-Saqri, Habib Ahmed Al-Jahdhami, and Asma Musabah Al-Badi. "Comparative study between Moringa peregrina plant extracts and a standard antibiotic against Candida albicans." Open Access Research Journal of Science and Technology 9, no. 2 (2023): 022–38. http://dx.doi.org/10.53022/oarjst.2023.9.2.0065.

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Candida albicans is a common fungus that can infect people, especially those who have compromised immune systems. In the face of declining efficacy of conventional antibiotics for treating fungus infections, natural plant-based remedies are gaining popularity. Moringa peregrina has long been used for its medicinal benefits, particularly for healing fungus infections. M. peregrina extracts were evaluated for their antifungal activity against C. albicans in vitro. A comparison was made between the antifungal susceptibility of plant extracts and the antifungal susceptibility of a common antifunga

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Bamazi, Bitang, Agnassim Banito, Lankondjoa Kolani, Tchein Nimblika, Koffi Koba, and Komla Sanda. "In vitro evaluation of plant-extracts activity on two tomato pathogenic fungi in Togo." Net Journal of Agricultural Science 10, no. 4 (2022): 90–94. http://dx.doi.org/10.30918/njas.104.22.023.

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The effects of plant-based formulation on two common fungi of tomato were carried out in vitro. A total of five concentrations of the formulation: 0.2, 0.4, 0.6, 0.8 and 1% were tested using agar dilution and agar diffusion methods. Significant antifungal effects were observed. The plant-based extract formulation was more effective with the agar dilution method in comparison to the diffusion one and also depend on the higher concentrations. The antifungal effects decreased with the incubation time and a high effect was recorded after three days of incubation with mycelial growth inhibition fro

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Vahedi-Shahandashti, Roya, Lisa Hahn, Jos Houbraken, and Cornelia Lass-Flörl. "Aspergillus Section Terrei and Antifungals: From Broth to Agar-Based Susceptibility Testing Methods." Journal of Fungi 9, no. 3 (2023): 306. http://dx.doi.org/10.3390/jof9030306.

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Providing timely antifungal treatment to patients suffering from life-threatening invasive fungal infections (IFIs) is essential. Due to the changing epidemiology and the emergence of antifungal resistance in Aspergillus, the most commonly responsible mold of IFIs, antifungal susceptibility testing (AFST) has become increasingly important to guide clinical decisions. This study assessed the essential agreement (EA) between broth microdilution methods (the Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST)) and the Etes

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Ma, Yang-Min, Xia Miao, Bin Jia, Zhao-Yang Sun, Si-Yue Ma, and Cong Yan. "Design, Synthesis, Antifungal Evaluation, Structure–Activity Relationship (SAR) Study, and Molecular Docking of Novel Spirotryprostatin A Derivatives." Molecules 29, no. 4 (2024): 864. http://dx.doi.org/10.3390/molecules29040864.

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Phytopathogenic fungi cause plant diseases and economic losses in agriculture. To efficiently control plant pathogen infections, a total of 19 spirotryprostatin A derivatives and 26 spirooxindole derivatives were designed, synthesized, and tested for their antifungal activity against ten plant pathogens. Additionally, the intermediates of spirooxindole derivatives were investigated, including proposing a mechanism for diastereoselectivity and performing amplification experiments. The bioassay results demonstrated that spirotryprostatin A derivatives possess good and broad-spectrum antifungal a

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